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Network neighborhood for query Sequence : SRBS1_MOUSE

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SRBS1_MOUSE
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SRBS1_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	409	Target Neighborhood Hits	409	Shared Neighborhood Hits	409
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
θ value	1.01238e-168 (rank : 2)	NC score	0.934573 (rank : 2)
Query Neighborhood Hits	409	Target Neighborhood Hits	396	Shared Neighborhood Hits	250
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_MOUSE
θ value	4.83544e-70 (rank : 3)	NC score	0.889999 (rank : 4)
Query Neighborhood Hits	409	Target Neighborhood Hits	286	Shared Neighborhood Hits	222
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
θ value	5.34618e-69 (rank : 4)	NC score	0.896506 (rank : 3)
Query Neighborhood Hits	409	Target Neighborhood Hits	270	Shared Neighborhood Hits	223
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ITSN2_MOUSE
θ value	1.38178e-16 (rank : 5)	NC score	0.458353 (rank : 73)
Query Neighborhood Hits	409	Target Neighborhood Hits	1371	Shared Neighborhood Hits	232
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
θ value	3.07829e-16 (rank : 6)	NC score	0.453153 (rank : 76)
Query Neighborhood Hits	409	Target Neighborhood Hits	1757	Shared Neighborhood Hits	266
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3K1_HUMAN
θ value	5.25075e-16 (rank : 7)	NC score	0.729191 (rank : 5)
Query Neighborhood Hits	409	Target Neighborhood Hits	341	Shared Neighborhood Hits	212
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	6.85773e-16 (rank : 8)	NC score	0.723064 (rank : 6)
Query Neighborhood Hits	409	Target Neighborhood Hits	332	Shared Neighborhood Hits	212
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ITSN2_HUMAN
θ value	8.95645e-16 (rank : 9)	NC score	0.479034 (rank : 65)
Query Neighborhood Hits	409	Target Neighborhood Hits	1173	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_MOUSE
θ value	1.52774e-15 (rank : 10)	NC score	0.453877 (rank : 75)
Query Neighborhood Hits	409	Target Neighborhood Hits	1669	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

GRB2_HUMAN
θ value	4.44505e-15 (rank : 11)	NC score	0.609829 (rank : 13)
Query Neighborhood Hits	409	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	4.44505e-15 (rank : 12)	NC score	0.608351 (rank : 16)
Query Neighborhood Hits	409	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

DNMBP_HUMAN
θ value	6.41864e-14 (rank : 13)	NC score	0.589115 (rank : 23)
Query Neighborhood Hits	409	Target Neighborhood Hits	413	Shared Neighborhood Hits	211
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CD2AP_HUMAN
θ value	1.09485e-13 (rank : 14)	NC score	0.721754 (rank : 7)
Query Neighborhood Hits	409	Target Neighborhood Hits	315	Shared Neighborhood Hits	211
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	7.09661e-13 (rank : 15)	NC score	0.717453 (rank : 8)
Query Neighborhood Hits	409	Target Neighborhood Hits	336	Shared Neighborhood Hits	215
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

DNMBP_MOUSE
θ value	9.26847e-13 (rank : 16)	NC score	0.586761 (rank : 27)
Query Neighborhood Hits	409	Target Neighborhood Hits	435	Shared Neighborhood Hits	221
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCK2_HUMAN
θ value	1.47974e-10 (rank : 17)	NC score	0.588404 (rank : 24)
Query Neighborhood Hits	409	Target Neighborhood Hits	310	Shared Neighborhood Hits	198
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP_MOUSE
θ value	5.62301e-10 (rank : 18)	NC score	0.582974 (rank : 30)
Query Neighborhood Hits	409	Target Neighborhood Hits	309	Shared Neighborhood Hits	206
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NEBL_HUMAN
θ value	2.79066e-09 (rank : 19)	NC score	0.512886 (rank : 58)
Query Neighborhood Hits	409	Target Neighborhood Hits	457	Shared Neighborhood Hits	184
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

GRAP_HUMAN
θ value	3.64472e-09 (rank : 20)	NC score	0.572874 (rank : 33)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	200
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK1_HUMAN
θ value	4.76016e-09 (rank : 21)	NC score	0.587694 (rank : 25)
Query Neighborhood Hits	409	Target Neighborhood Hits	312	Shared Neighborhood Hits	197
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3G2_HUMAN
θ value	8.11959e-09 (rank : 22)	NC score	0.618395 (rank : 11)
Query Neighborhood Hits	409	Target Neighborhood Hits	324	Shared Neighborhood Hits	198
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_MOUSE
θ value	1.06045e-08 (rank : 23)	NC score	0.606067 (rank : 18)
Query Neighborhood Hits	409	Target Neighborhood Hits	291	Shared Neighborhood Hits	194
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

VAV2_HUMAN
θ value	1.06045e-08 (rank : 24)	NC score	0.486176 (rank : 62)
Query Neighborhood Hits	409	Target Neighborhood Hits	453	Shared Neighborhood Hits	193
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	1.06045e-08 (rank : 25)	NC score	0.487273 (rank : 61)
Query Neighborhood Hits	409	Target Neighborhood Hits	456	Shared Neighborhood Hits	194
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG7_MOUSE
θ value	1.38499e-08 (rank : 26)	NC score	0.555575 (rank : 36)
Query Neighborhood Hits	409	Target Neighborhood Hits	396	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

LASP1_MOUSE
θ value	1.80886e-08 (rank : 27)	NC score	0.541392 (rank : 43)
Query Neighborhood Hits	409	Target Neighborhood Hits	297	Shared Neighborhood Hits	168
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SH3G3_HUMAN
θ value	2.36244e-08 (rank : 28)	NC score	0.617825 (rank : 12)
Query Neighborhood Hits	409	Target Neighborhood Hits	222	Shared Neighborhood Hits	187
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_HUMAN
θ value	3.08544e-08 (rank : 29)	NC score	0.599274 (rank : 21)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	195
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

VAV3_HUMAN
θ value	4.0297e-08 (rank : 30)	NC score	0.461689 (rank : 70)
Query Neighborhood Hits	409	Target Neighborhood Hits	398	Shared Neighborhood Hits	188
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

LASP1_HUMAN
θ value	5.26297e-08 (rank : 31)	NC score	0.541152 (rank : 44)
Query Neighborhood Hits	409	Target Neighborhood Hits	293	Shared Neighborhood Hits	168
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SH3G2_MOUSE
θ value	5.26297e-08 (rank : 32)	NC score	0.609712 (rank : 14)
Query Neighborhood Hits	409	Target Neighborhood Hits	319	Shared Neighborhood Hits	198
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

VAV3_MOUSE
θ value	8.97725e-08 (rank : 33)	NC score	0.455537 (rank : 74)
Query Neighborhood Hits	409	Target Neighborhood Hits	404	Shared Neighborhood Hits	185
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

NEBU_HUMAN
θ value	1.17247e-07 (rank : 34)	NC score	0.433296 (rank : 81)
Query Neighborhood Hits	409	Target Neighborhood Hits	420	Shared Neighborhood Hits	182
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SH3G3_MOUSE
θ value	1.17247e-07 (rank : 35)	NC score	0.624539 (rank : 10)
Query Neighborhood Hits	409	Target Neighborhood Hits	236	Shared Neighborhood Hits	193
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ABI1_MOUSE
θ value	1.53129e-07 (rank : 36)	NC score	0.602848 (rank : 19)
Query Neighborhood Hits	409	Target Neighborhood Hits	246	Shared Neighborhood Hits	180
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ARHG6_MOUSE
θ value	3.41135e-07 (rank : 37)	NC score	0.532221 (rank : 50)
Query Neighborhood Hits	409	Target Neighborhood Hits	394	Shared Neighborhood Hits	191
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PPIP1_HUMAN
θ value	4.45536e-07 (rank : 38)	NC score	0.564348 (rank : 34)
Query Neighborhood Hits	409	Target Neighborhood Hits	389	Shared Neighborhood Hits	202
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI1_HUMAN
θ value	7.59969e-07 (rank : 39)	NC score	0.581407 (rank : 32)
Query Neighborhood Hits	409	Target Neighborhood Hits	257	Shared Neighborhood Hits	182
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

STAC_HUMAN
θ value	9.92553e-07 (rank : 40)	NC score	0.546548 (rank : 39)
Query Neighborhood Hits	409	Target Neighborhood Hits	276	Shared Neighborhood Hits	180
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF4_HUMAN
θ value	1.29631e-06 (rank : 41)	NC score	0.594566 (rank : 22)
Query Neighborhood Hits	409	Target Neighborhood Hits	161	Shared Neighborhood Hits	131
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ARHG6_HUMAN
θ value	2.21117e-06 (rank : 42)	NC score	0.525823 (rank : 53)
Query Neighborhood Hits	409	Target Neighborhood Hits	376	Shared Neighborhood Hits	192
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SRC8_MOUSE
θ value	2.21117e-06 (rank : 43)	NC score	0.586199 (rank : 28)
Query Neighborhood Hits	409	Target Neighborhood Hits	292	Shared Neighborhood Hits	190
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ARHG7_HUMAN
θ value	2.88788e-06 (rank : 44)	NC score	0.534912 (rank : 47)
Query Neighborhood Hits	409	Target Neighborhood Hits	347	Shared Neighborhood Hits	198
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PPIP1_MOUSE
θ value	2.88788e-06 (rank : 45)	NC score	0.556808 (rank : 35)
Query Neighborhood Hits	409	Target Neighborhood Hits	377	Shared Neighborhood Hits	205
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SPTA2_HUMAN
θ value	2.88788e-06 (rank : 46)	NC score	0.254696 (rank : 133)
Query Neighborhood Hits	409	Target Neighborhood Hits	888	Shared Neighborhood Hits	189
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

NCF4_MOUSE
θ value	4.92598e-06 (rank : 47)	NC score	0.609506 (rank : 15)
Query Neighborhood Hits	409	Target Neighborhood Hits	177	Shared Neighborhood Hits	149
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

VAV_HUMAN
θ value	4.92598e-06 (rank : 48)	NC score	0.494040 (rank : 60)
Query Neighborhood Hits	409	Target Neighborhood Hits	452	Shared Neighborhood Hits	200
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NCF2_HUMAN
θ value	6.43352e-06 (rank : 49)	NC score	0.674696 (rank : 9)
Query Neighborhood Hits	409	Target Neighborhood Hits	229	Shared Neighborhood Hits	180
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VAV_MOUSE
θ value	6.43352e-06 (rank : 50)	NC score	0.494452 (rank : 59)
Query Neighborhood Hits	409	Target Neighborhood Hits	430	Shared Neighborhood Hits	202
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ABI2_HUMAN
θ value	8.40245e-06 (rank : 51)	NC score	0.602090 (rank : 20)
Query Neighborhood Hits	409	Target Neighborhood Hits	350	Shared Neighborhood Hits	205
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	8.40245e-06 (rank : 52)	NC score	0.606092 (rank : 17)
Query Neighborhood Hits	409	Target Neighborhood Hits	266	Shared Neighborhood Hits	191
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

STAC_MOUSE
θ value	8.40245e-06 (rank : 53)	NC score	0.532882 (rank : 49)
Query Neighborhood Hits	409	Target Neighborhood Hits	268	Shared Neighborhood Hits	175
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

FNBP2_HUMAN
θ value	1.43324e-05 (rank : 54)	NC score	0.325637 (rank : 107)
Query Neighborhood Hits	409	Target Neighborhood Hits	432	Shared Neighborhood Hits	166
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

STS1_HUMAN
θ value	1.43324e-05 (rank : 55)	NC score	0.316788 (rank : 112)
Query Neighborhood Hits	409	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STAM1_MOUSE
θ value	1.87187e-05 (rank : 56)	NC score	0.540239 (rank : 45)
Query Neighborhood Hits	409	Target Neighborhood Hits	273	Shared Neighborhood Hits	190
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

OSTF1_HUMAN
θ value	2.44474e-05 (rank : 57)	NC score	0.475352 (rank : 66)
Query Neighborhood Hits	409	Target Neighborhood Hits	466	Shared Neighborhood Hits	200
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SRGP2_HUMAN
θ value	2.44474e-05 (rank : 58)	NC score	0.341140 (rank : 101)
Query Neighborhood Hits	409	Target Neighborhood Hits	331	Shared Neighborhood Hits	162
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

STAM2_HUMAN
θ value	2.44474e-05 (rank : 59)	NC score	0.520869 (rank : 56)
Query Neighborhood Hits	409	Target Neighborhood Hits	288	Shared Neighborhood Hits	191
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STS1_MOUSE
θ value	2.44474e-05 (rank : 60)	NC score	0.315576 (rank : 113)
Query Neighborhood Hits	409	Target Neighborhood Hits	104	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

CRK_MOUSE
θ value	3.19293e-05 (rank : 61)	NC score	0.523118 (rank : 55)
Query Neighborhood Hits	409	Target Neighborhood Hits	314	Shared Neighborhood Hits	189
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

RHG04_HUMAN
θ value	3.19293e-05 (rank : 62)	NC score	0.362041 (rank : 97)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	168
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP2_MOUSE
θ value	3.19293e-05 (rank : 63)	NC score	0.343094 (rank : 100)
Query Neighborhood Hits	409	Target Neighborhood Hits	324	Shared Neighborhood Hits	162
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ABI3_MOUSE
θ value	4.1701e-05 (rank : 64)	NC score	0.545375 (rank : 40)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	150
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

M3KL4_HUMAN
θ value	4.1701e-05 (rank : 65)	NC score	0.175006 (rank : 182)
Query Neighborhood Hits	409	Target Neighborhood Hits	1087	Shared Neighborhood Hits	192
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

NGEF_HUMAN
θ value	4.1701e-05 (rank : 66)	NC score	0.284368 (rank : 124)
Query Neighborhood Hits	409	Target Neighborhood Hits	166	Shared Neighborhood Hits	87
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SRGP1_HUMAN
θ value	4.1701e-05 (rank : 67)	NC score	0.323901 (rank : 109)
Query Neighborhood Hits	409	Target Neighborhood Hits	390	Shared Neighborhood Hits	152
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAM1_HUMAN
θ value	4.1701e-05 (rank : 68)	NC score	0.537618 (rank : 46)
Query Neighborhood Hits	409	Target Neighborhood Hits	271	Shared Neighborhood Hits	189
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI3_HUMAN
θ value	5.44631e-05 (rank : 69)	NC score	0.548751 (rank : 38)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	152
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CRK_HUMAN
θ value	5.44631e-05 (rank : 70)	NC score	0.514910 (rank : 57)
Query Neighborhood Hits	409	Target Neighborhood Hits	308	Shared Neighborhood Hits	190
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCF1_MOUSE
θ value	5.44631e-05 (rank : 71)	NC score	0.543590 (rank : 42)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	168
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NGEF_MOUSE
θ value	5.44631e-05 (rank : 72)	NC score	0.287354 (rank : 123)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	102
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MYO1E_HUMAN
θ value	7.1131e-05 (rank : 73)	NC score	0.239740 (rank : 142)
Query Neighborhood Hits	409	Target Neighborhood Hits	293	Shared Neighborhood Hits	190
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

CRKL_HUMAN
θ value	9.29e-05 (rank : 74)	NC score	0.529569 (rank : 51)
Query Neighborhood Hits	409	Target Neighborhood Hits	313	Shared Neighborhood Hits	191
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRAP2_MOUSE
θ value	9.29e-05 (rank : 75)	NC score	0.553476 (rank : 37)
Query Neighborhood Hits	409	Target Neighborhood Hits	297	Shared Neighborhood Hits	196
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

HCLS1_MOUSE
θ value	9.29e-05 (rank : 76)	NC score	0.587034 (rank : 26)
Query Neighborhood Hits	409	Target Neighborhood Hits	329	Shared Neighborhood Hits	196
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAM2_MOUSE
θ value	9.29e-05 (rank : 77)	NC score	0.528023 (rank : 52)
Query Neighborhood Hits	409	Target Neighborhood Hits	285	Shared Neighborhood Hits	192
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

GRAP2_HUMAN
θ value	0.000121331 (rank : 78)	NC score	0.544312 (rank : 41)
Query Neighborhood Hits	409	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

M3K9_HUMAN
θ value	0.000158464 (rank : 79)	NC score	0.157353 (rank : 204)
Query Neighborhood Hits	409	Target Neighborhood Hits	1123	Shared Neighborhood Hits	197
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

OSTF1_MOUSE
θ value	0.000158464 (rank : 80)	NC score	0.459002 (rank : 71)
Query Neighborhood Hits	409	Target Neighborhood Hits	467	Shared Neighborhood Hits	199
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SRC8_HUMAN
θ value	0.000158464 (rank : 81)	NC score	0.585735 (rank : 29)
Query Neighborhood Hits	409	Target Neighborhood Hits	269	Shared Neighborhood Hits	191
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STS2_HUMAN
θ value	0.000158464 (rank : 82)	NC score	0.356283 (rank : 98)
Query Neighborhood Hits	409	Target Neighborhood Hits	108	Shared Neighborhood Hits	95
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

CRKL_MOUSE
θ value	0.00020696 (rank : 83)	NC score	0.524006 (rank : 54)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	188
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

HCLS1_HUMAN
θ value	0.00020696 (rank : 84)	NC score	0.582156 (rank : 31)
Query Neighborhood Hits	409	Target Neighborhood Hits	358	Shared Neighborhood Hits	191
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MYO1F_HUMAN
θ value	0.00035302 (rank : 85)	NC score	0.246601 (rank : 138)
Query Neighborhood Hits	409	Target Neighborhood Hits	275	Shared Neighborhood Hits	186
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

P85B_HUMAN
θ value	0.00035302 (rank : 86)	NC score	0.236431 (rank : 147)
Query Neighborhood Hits	409	Target Neighborhood Hits	543	Shared Neighborhood Hits	103
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CSK_HUMAN
θ value	0.000461057 (rank : 87)	NC score	0.136401 (rank : 223)
Query Neighborhood Hits	409	Target Neighborhood Hits	1009	Shared Neighborhood Hits	149
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.000461057 (rank : 88)	NC score	0.136597 (rank : 222)
Query Neighborhood Hits	409	Target Neighborhood Hits	1009	Shared Neighborhood Hits	149
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

M3K11_HUMAN
θ value	0.000461057 (rank : 89)	NC score	0.161853 (rank : 199)
Query Neighborhood Hits	409	Target Neighborhood Hits	1136	Shared Neighborhood Hits	204
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MYO1F_MOUSE
θ value	0.000461057 (rank : 90)	NC score	0.245330 (rank : 139)
Query Neighborhood Hits	409	Target Neighborhood Hits	262	Shared Neighborhood Hits	185
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

CBP_MOUSE
θ value	0.000602161 (rank : 91)	NC score	0.078885 (rank : 337)
Query Neighborhood Hits	409	Target Neighborhood Hits	1051	Shared Neighborhood Hits	92
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

JIP2_HUMAN
θ value	0.000602161 (rank : 92)	NC score	0.237216 (rank : 146)
Query Neighborhood Hits	409	Target Neighborhood Hits	288	Shared Neighborhood Hits	87
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.000602161 (rank : 93)	NC score	0.237662 (rank : 144)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	67
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

NCF1_HUMAN
θ value	0.000786445 (rank : 94)	NC score	0.534633 (rank : 48)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	157
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CBP_HUMAN
θ value	0.00102713 (rank : 95)	NC score	0.078161 (rank : 341)
Query Neighborhood Hits	409	Target Neighborhood Hits	941	Shared Neighborhood Hits	82
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

YES_HUMAN
θ value	0.00102713 (rank : 96)	NC score	0.174475 (rank : 183)
Query Neighborhood Hits	409	Target Neighborhood Hits	1059	Shared Neighborhood Hits	193
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.00102713 (rank : 97)	NC score	0.176144 (rank : 180)
Query Neighborhood Hits	409	Target Neighborhood Hits	1052	Shared Neighborhood Hits	193
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

AHI1_MOUSE
θ value	0.00175202 (rank : 98)	NC score	0.386328 (rank : 88)
Query Neighborhood Hits	409	Target Neighborhood Hits	496	Shared Neighborhood Hits	200
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

P85B_MOUSE
θ value	0.00175202 (rank : 99)	NC score	0.228769 (rank : 150)
Query Neighborhood Hits	409	Target Neighborhood Hits	519	Shared Neighborhood Hits	100
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN2_HUMAN
θ value	0.00175202 (rank : 100)	NC score	0.484684 (rank : 63)
Query Neighborhood Hits	409	Target Neighborhood Hits	339	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLCG1_MOUSE
θ value	0.00175202 (rank : 101)	NC score	0.390937 (rank : 86)
Query Neighborhood Hits	409	Target Neighborhood Hits	314	Shared Neighborhood Hits	167
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RBBP6_MOUSE
θ value	0.00175202 (rank : 102)	NC score	0.077010 (rank : 343)
Query Neighborhood Hits	409	Target Neighborhood Hits	1014	Shared Neighborhood Hits	69
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

M3K10_HUMAN
θ value	0.00228821 (rank : 103)	NC score	0.142875 (rank : 217)
Query Neighborhood Hits	409	Target Neighborhood Hits	1071	Shared Neighborhood Hits	173
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MKL1_MOUSE
θ value	0.00298849 (rank : 104)	NC score	0.062766 (rank : 384)
Query Neighborhood Hits	409	Target Neighborhood Hits	667	Shared Neighborhood Hits	71
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

SPTA1_HUMAN
θ value	0.00298849 (rank : 105)	NC score	0.232704 (rank : 149)
Query Neighborhood Hits	409	Target Neighborhood Hits	748	Shared Neighborhood Hits	177
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	0.00298849 (rank : 106)	NC score	0.237661 (rank : 145)
Query Neighborhood Hits	409	Target Neighborhood Hits	675	Shared Neighborhood Hits	171
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NRIP1_MOUSE
θ value	0.00390308 (rank : 107)	NC score	0.057960 (rank : 400)
Query Neighborhood Hits	409	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CBD1, Q8C3Y8, Q9Z2K2	Gene names	Nrip1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

PACN2_MOUSE
θ value	0.00390308 (rank : 108)	NC score	0.480636 (rank : 64)
Query Neighborhood Hits	409	Target Neighborhood Hits	382	Shared Neighborhood Hits	196
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SRC_HUMAN
θ value	0.00390308 (rank : 109)	NC score	0.174162 (rank : 184)
Query Neighborhood Hits	409	Target Neighborhood Hits	1058	Shared Neighborhood Hits	195
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

JIP1_HUMAN
θ value	0.00509761 (rank : 110)	NC score	0.212137 (rank : 158)
Query Neighborhood Hits	409	Target Neighborhood Hits	271	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	0.00509761 (rank : 111)	NC score	0.216670 (rank : 154)
Query Neighborhood Hits	409	Target Neighborhood Hits	259	Shared Neighborhood Hits	84
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MDC1_HUMAN
θ value	0.00509761 (rank : 112)	NC score	0.091011 (rank : 308)
Query Neighborhood Hits	409	Target Neighborhood Hits	1446	Shared Neighborhood Hits	125
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

DDEF2_MOUSE
θ value	0.00665767 (rank : 113)	NC score	0.248133 (rank : 134)
Query Neighborhood Hits	409	Target Neighborhood Hits	625	Shared Neighborhood Hits	182
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

AHI1_HUMAN
θ value	0.00869519 (rank : 114)	NC score	0.383010 (rank : 89)
Query Neighborhood Hits	409	Target Neighborhood Hits	537	Shared Neighborhood Hits	202
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG5_HUMAN
θ value	0.00869519 (rank : 115)	NC score	0.300254 (rank : 115)
Query Neighborhood Hits	409	Target Neighborhood Hits	172	Shared Neighborhood Hits	102
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

DDEF1_MOUSE
θ value	0.00869519 (rank : 116)	NC score	0.260125 (rank : 131)
Query Neighborhood Hits	409	Target Neighborhood Hits	592	Shared Neighborhood Hits	161
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FYN_HUMAN
θ value	0.00869519 (rank : 117)	NC score	0.176160 (rank : 179)
Query Neighborhood Hits	409	Target Neighborhood Hits	1078	Shared Neighborhood Hits	198
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.00869519 (rank : 118)	NC score	0.179139 (rank : 176)
Query Neighborhood Hits	409	Target Neighborhood Hits	1073	Shared Neighborhood Hits	198
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

MILK1_HUMAN
θ value	0.00869519 (rank : 119)	NC score	0.050362 (rank : 442)
Query Neighborhood Hits	409	Target Neighborhood Hits	427	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PLCG1_HUMAN
θ value	0.00869519 (rank : 120)	NC score	0.372436 (rank : 92)
Query Neighborhood Hits	409	Target Neighborhood Hits	293	Shared Neighborhood Hits	159
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	0.00869519 (rank : 121)	NC score	0.371777 (rank : 93)
Query Neighborhood Hits	409	Target Neighborhood Hits	280	Shared Neighborhood Hits	157
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SNX18_MOUSE
θ value	0.00869519 (rank : 122)	NC score	0.378016 (rank : 90)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	134
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PACN1_HUMAN
θ value	0.0113563 (rank : 123)	NC score	0.473000 (rank : 67)
Query Neighborhood Hits	409	Target Neighborhood Hits	320	Shared Neighborhood Hits	185
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.0113563 (rank : 124)	NC score	0.472340 (rank : 68)
Query Neighborhood Hits	409	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN3_HUMAN
θ value	0.0113563 (rank : 125)	NC score	0.452052 (rank : 77)
Query Neighborhood Hits	409	Target Neighborhood Hits	385	Shared Neighborhood Hits	185
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

FGR_HUMAN
θ value	0.0148317 (rank : 126)	NC score	0.177461 (rank : 177)
Query Neighborhood Hits	409	Target Neighborhood Hits	1067	Shared Neighborhood Hits	193
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SHLB2_HUMAN
θ value	0.0148317 (rank : 127)	NC score	0.295152 (rank : 118)
Query Neighborhood Hits	409	Target Neighborhood Hits	86	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	0.0148317 (rank : 128)	NC score	0.296849 (rank : 117)
Query Neighborhood Hits	409	Target Neighborhood Hits	88	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

BTK_HUMAN
θ value	0.0193708 (rank : 129)	NC score	0.154548 (rank : 207)
Query Neighborhood Hits	409	Target Neighborhood Hits	1026	Shared Neighborhood Hits	190
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DOCK1_HUMAN
θ value	0.0193708 (rank : 130)	NC score	0.212398 (rank : 156)
Query Neighborhood Hits	409	Target Neighborhood Hits	191	Shared Neighborhood Hits	123
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

NPHP1_MOUSE
θ value	0.0193708 (rank : 131)	NC score	0.442013 (rank : 79)
Query Neighborhood Hits	409	Target Neighborhood Hits	267	Shared Neighborhood Hits	171
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

P85A_MOUSE
θ value	0.0193708 (rank : 132)	NC score	0.258020 (rank : 132)
Query Neighborhood Hits	409	Target Neighborhood Hits	435	Shared Neighborhood Hits	132
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RBBP6_HUMAN
θ value	0.0193708 (rank : 133)	NC score	0.065616 (rank : 378)
Query Neighborhood Hits	409	Target Neighborhood Hits	1135	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

BCAR1_HUMAN
θ value	0.0252991 (rank : 134)	NC score	0.368951 (rank : 94)
Query Neighborhood Hits	409	Target Neighborhood Hits	554	Shared Neighborhood Hits	187
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	0.0252991 (rank : 135)	NC score	0.375925 (rank : 91)
Query Neighborhood Hits	409	Target Neighborhood Hits	438	Shared Neighborhood Hits	183
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PACN3_MOUSE
θ value	0.0252991 (rank : 136)	NC score	0.449011 (rank : 78)
Query Neighborhood Hits	409	Target Neighborhood Hits	380	Shared Neighborhood Hits	189
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SHLB1_MOUSE
θ value	0.0252991 (rank : 137)	NC score	0.326698 (rank : 106)
Query Neighborhood Hits	409	Target Neighborhood Hits	101	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

DBNL_HUMAN
θ value	0.0330416 (rank : 138)	NC score	0.466137 (rank : 69)
Query Neighborhood Hits	409	Target Neighborhood Hits	244	Shared Neighborhood Hits	158
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.0330416 (rank : 139)	NC score	0.458696 (rank : 72)
Query Neighborhood Hits	409	Target Neighborhood Hits	306	Shared Neighborhood Hits	160
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EFS_HUMAN
θ value	0.0330416 (rank : 140)	NC score	0.387778 (rank : 87)
Query Neighborhood Hits	409	Target Neighborhood Hits	348	Shared Neighborhood Hits	167
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SHLB1_HUMAN
θ value	0.0330416 (rank : 141)	NC score	0.320050 (rank : 110)
Query Neighborhood Hits	409	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

NFH_MOUSE
θ value	0.0431538 (rank : 142)	NC score	0.047013 (rank : 450)
Query Neighborhood Hits	409	Target Neighborhood Hits	2247	Shared Neighborhood Hits	147
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SNX18_HUMAN
θ value	0.0431538 (rank : 143)	NC score	0.368934 (rank : 95)
Query Neighborhood Hits	409	Target Neighborhood Hits	207	Shared Neighborhood Hits	139
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

TXK_MOUSE
θ value	0.0431538 (rank : 144)	NC score	0.128835 (rank : 233)
Query Neighborhood Hits	409	Target Neighborhood Hits	980	Shared Neighborhood Hits	156
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

EFS_MOUSE
θ value	0.0563607 (rank : 145)	NC score	0.399535 (rank : 83)
Query Neighborhood Hits	409	Target Neighborhood Hits	389	Shared Neighborhood Hits	178
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

P85A_HUMAN
θ value	0.0563607 (rank : 146)	NC score	0.243960 (rank : 140)
Query Neighborhood Hits	409	Target Neighborhood Hits	479	Shared Neighborhood Hits	126
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RHG09_HUMAN
θ value	0.0563607 (rank : 147)	NC score	0.113390 (rank : 263)
Query Neighborhood Hits	409	Target Neighborhood Hits	186	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

AF9_HUMAN
θ value	0.0736092 (rank : 148)	NC score	0.062981 (rank : 383)
Query Neighborhood Hits	409	Target Neighborhood Hits	202	Shared Neighborhood Hits	23
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

ANK2_HUMAN
θ value	0.0736092 (rank : 149)	NC score	0.044597 (rank : 453)
Query Neighborhood Hits	409	Target Neighborhood Hits	1615	Shared Neighborhood Hits	126
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

BTK_MOUSE
θ value	0.0736092 (rank : 150)	NC score	0.148794 (rank : 212)
Query Neighborhood Hits	409	Target Neighborhood Hits	1017	Shared Neighborhood Hits	180
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FGR_MOUSE
θ value	0.0736092 (rank : 151)	NC score	0.169147 (rank : 188)
Query Neighborhood Hits	409	Target Neighborhood Hits	1069	Shared Neighborhood Hits	193
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MX1_MOUSE
θ value	0.0736092 (rank : 152)	NC score	0.034313 (rank : 475)
Query Neighborhood Hits	409	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

RIMB2_MOUSE
θ value	0.0736092 (rank : 153)	NC score	0.331735 (rank : 105)
Query Neighborhood Hits	409	Target Neighborhood Hits	246	Shared Neighborhood Hits	114
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ARNT_MOUSE
θ value	0.0961366 (rank : 154)	NC score	0.024254 (rank : 500)
Query Neighborhood Hits	409	Target Neighborhood Hits	213	Shared Neighborhood Hits	21
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BAIP2_HUMAN
θ value	0.0961366 (rank : 155)	NC score	0.176036 (rank : 181)
Query Neighborhood Hits	409	Target Neighborhood Hits	192	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	0.0961366 (rank : 156)	NC score	0.177060 (rank : 178)
Query Neighborhood Hits	409	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

CASL_HUMAN
θ value	0.0961366 (rank : 157)	NC score	0.339578 (rank : 104)
Query Neighborhood Hits	409	Target Neighborhood Hits	259	Shared Neighborhood Hits	151
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.0961366 (rank : 158)	NC score	0.344041 (rank : 99)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	149
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ES8L3_HUMAN
θ value	0.0961366 (rank : 159)	NC score	0.272487 (rank : 127)
Query Neighborhood Hits	409	Target Neighborhood Hits	206	Shared Neighborhood Hits	124
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FUT8_HUMAN
θ value	0.0961366 (rank : 160)	NC score	0.153808 (rank : 208)
Query Neighborhood Hits	409	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

MLL2_HUMAN
θ value	0.0961366 (rank : 161)	NC score	0.053305 (rank : 423)
Query Neighborhood Hits	409	Target Neighborhood Hits	1788	Shared Neighborhood Hits	113
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NPHP1_HUMAN
θ value	0.0961366 (rank : 162)	NC score	0.396515 (rank : 84)
Query Neighborhood Hits	409	Target Neighborhood Hits	288	Shared Neighborhood Hits	160
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RIMB1_MOUSE
θ value	0.0961366 (rank : 163)	NC score	0.187535 (rank : 172)
Query Neighborhood Hits	409	Target Neighborhood Hits	1376	Shared Neighborhood Hits	188
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

AFF4_MOUSE
θ value	0.125558 (rank : 164)	NC score	0.061702 (rank : 390)
Query Neighborhood Hits	409	Target Neighborhood Hits	581	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ARHG4_HUMAN
θ value	0.125558 (rank : 165)	NC score	0.362691 (rank : 96)
Query Neighborhood Hits	409	Target Neighborhood Hits	242	Shared Neighborhood Hits	159
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

EPS8_HUMAN
θ value	0.125558 (rank : 166)	NC score	0.221892 (rank : 152)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	107
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

HCK_HUMAN
θ value	0.125558 (rank : 167)	NC score	0.148110 (rank : 213)
Query Neighborhood Hits	409	Target Neighborhood Hits	1035	Shared Neighborhood Hits	183
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

PRDM1_HUMAN
θ value	0.125558 (rank : 168)	NC score	-0.002392 (rank : 592)
Query Neighborhood Hits	409	Target Neighborhood Hits	734	Shared Neighborhood Hits	13
SwissProt Accessions	O75626	Gene names	PRDM1, BLIMP1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1) (Positive regulatory domain I-binding factor 1) (PRDI- binding factor 1) (PRDI-BF1).

RHG26_HUMAN
θ value	0.125558 (rank : 169)	NC score	0.287535 (rank : 122)
Query Neighborhood Hits	409	Target Neighborhood Hits	281	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

TCOF_HUMAN
θ value	0.125558 (rank : 170)	NC score	0.062315 (rank : 387)
Query Neighborhood Hits	409	Target Neighborhood Hits	543	Shared Neighborhood Hits	51
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

ZSCA5_HUMAN
θ value	0.125558 (rank : 171)	NC score	-0.001548 (rank : 591)
Query Neighborhood Hits	409	Target Neighborhood Hits	862	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BUG6	Gene names	ZSCAN5, ZNF495
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 5 (Zinc finger protein 495).

ASPP2_HUMAN
θ value	0.163984 (rank : 172)	NC score	0.212391 (rank : 157)
Query Neighborhood Hits	409	Target Neighborhood Hits	1156	Shared Neighborhood Hits	189
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ATX2_MOUSE
θ value	0.163984 (rank : 173)	NC score	0.044445 (rank : 454)
Query Neighborhood Hits	409	Target Neighborhood Hits	445	Shared Neighborhood Hits	49
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

DOCK3_HUMAN
θ value	0.163984 (rank : 174)	NC score	0.078488 (rank : 339)
Query Neighborhood Hits	409	Target Neighborhood Hits	87	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	0.163984 (rank : 175)	NC score	0.081648 (rank : 335)
Query Neighborhood Hits	409	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

ANKS6_HUMAN
θ value	0.21417 (rank : 176)	NC score	0.025717 (rank : 495)
Query Neighborhood Hits	409	Target Neighborhood Hits	411	Shared Neighborhood Hits	30
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ASPP1_MOUSE
θ value	0.21417 (rank : 177)	NC score	0.247325 (rank : 135)
Query Neighborhood Hits	409	Target Neighborhood Hits	1244	Shared Neighborhood Hits	212
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DDEF2_HUMAN
θ value	0.21417 (rank : 178)	NC score	0.239304 (rank : 143)
Query Neighborhood Hits	409	Target Neighborhood Hits	599	Shared Neighborhood Hits	177
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HCK_MOUSE
θ value	0.21417 (rank : 179)	NC score	0.149453 (rank : 211)
Query Neighborhood Hits	409	Target Neighborhood Hits	1029	Shared Neighborhood Hits	184
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

PARG_HUMAN
θ value	0.21417 (rank : 180)	NC score	0.037282 (rank : 467)
Query Neighborhood Hits	409	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W56, Q6E4P6, Q6E4P7, Q7Z742, Q9Y4W7	Gene names	PARG
Domain Architecture	No domain graphic available
Description	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143).

RIMB1_HUMAN
θ value	0.21417 (rank : 181)	NC score	0.193464 (rank : 165)
Query Neighborhood Hits	409	Target Neighborhood Hits	1479	Shared Neighborhood Hits	182
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SNX9_HUMAN
θ value	0.21417 (rank : 182)	NC score	0.271808 (rank : 128)
Query Neighborhood Hits	409	Target Neighborhood Hits	148	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

BLK_HUMAN
θ value	0.279714 (rank : 183)	NC score	0.133074 (rank : 227)
Query Neighborhood Hits	409	Target Neighborhood Hits	994	Shared Neighborhood Hits	155
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FUT8_MOUSE
θ value	0.279714 (rank : 184)	NC score	0.147648 (rank : 214)
Query Neighborhood Hits	409	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

IWS1_HUMAN
θ value	0.279714 (rank : 185)	NC score	0.057873 (rank : 401)
Query Neighborhood Hits	409	Target Neighborhood Hits	1241	Shared Neighborhood Hits	96
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
θ value	0.279714 (rank : 186)	NC score	0.053999 (rank : 416)
Query Neighborhood Hits	409	Target Neighborhood Hits	1258	Shared Neighborhood Hits	93
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LYN_MOUSE
θ value	0.279714 (rank : 187)	NC score	0.137861 (rank : 221)
Query Neighborhood Hits	409	Target Neighborhood Hits	1023	Shared Neighborhood Hits	170
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K3_MOUSE
θ value	0.279714 (rank : 188)	NC score	0.029195 (rank : 486)
Query Neighborhood Hits	409	Target Neighborhood Hits	876	Shared Neighborhood Hits	52
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

RHG25_MOUSE
θ value	0.279714 (rank : 189)	NC score	0.069605 (rank : 366)
Query Neighborhood Hits	409	Target Neighborhood Hits	492	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SNX9_MOUSE
θ value	0.279714 (rank : 190)	NC score	0.246991 (rank : 136)
Query Neighborhood Hits	409	Target Neighborhood Hits	141	Shared Neighborhood Hits	94
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SYN3_MOUSE
θ value	0.279714 (rank : 191)	NC score	0.032734 (rank : 479)
Query Neighborhood Hits	409	Target Neighborhood Hits	200	Shared Neighborhood Hits	29
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

ADDB_HUMAN
θ value	0.365318 (rank : 192)	NC score	0.024114 (rank : 501)
Query Neighborhood Hits	409	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	P35612, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691	Gene names	ADD2, ADDB
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta).

BLK_MOUSE
θ value	0.365318 (rank : 193)	NC score	0.130621 (rank : 231)
Query Neighborhood Hits	409	Target Neighborhood Hits	992	Shared Neighborhood Hits	144
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FRK_HUMAN
θ value	0.365318 (rank : 194)	NC score	0.139448 (rank : 219)
Query Neighborhood Hits	409	Target Neighborhood Hits	1058	Shared Neighborhood Hits	187
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ANM2_HUMAN
θ value	0.47712 (rank : 195)	NC score	0.274354 (rank : 125)
Query Neighborhood Hits	409	Target Neighborhood Hits	175	Shared Neighborhood Hits	144
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHGG_HUMAN
θ value	0.47712 (rank : 196)	NC score	0.212476 (rank : 155)
Query Neighborhood Hits	409	Target Neighborhood Hits	129	Shared Neighborhood Hits	54
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BIN1_HUMAN
θ value	0.47712 (rank : 197)	NC score	0.192223 (rank : 168)
Query Neighborhood Hits	409	Target Neighborhood Hits	335	Shared Neighborhood Hits	95
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	0.47712 (rank : 198)	NC score	0.192328 (rank : 167)
Query Neighborhood Hits	409	Target Neighborhood Hits	283	Shared Neighborhood Hits	95
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CRTC1_HUMAN
θ value	0.47712 (rank : 199)	NC score	0.042586 (rank : 456)
Query Neighborhood Hits	409	Target Neighborhood Hits	319	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

CT032_HUMAN
θ value	0.47712 (rank : 200)	NC score	0.394589 (rank : 85)
Query Neighborhood Hits	409	Target Neighborhood Hits	235	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DOCK4_HUMAN
θ value	0.47712 (rank : 201)	NC score	0.081801 (rank : 334)
Query Neighborhood Hits	409	Target Neighborhood Hits	237	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	0.47712 (rank : 202)	NC score	0.082141 (rank : 333)
Query Neighborhood Hits	409	Target Neighborhood Hits	210	Shared Neighborhood Hits	39
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

PSIP1_MOUSE
θ value	0.47712 (rank : 203)	NC score	0.030349 (rank : 485)
Query Neighborhood Hits	409	Target Neighborhood Hits	313	Shared Neighborhood Hits	24
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

SRC_MOUSE
θ value	0.47712 (rank : 204)	NC score	0.150369 (rank : 210)
Query Neighborhood Hits	409	Target Neighborhood Hits	1033	Shared Neighborhood Hits	174
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ARHGG_MOUSE
θ value	0.62314 (rank : 205)	NC score	0.236032 (rank : 148)
Query Neighborhood Hits	409	Target Neighborhood Hits	152	Shared Neighborhood Hits	71
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	0.62314 (rank : 206)	NC score	0.243613 (rank : 141)
Query Neighborhood Hits	409	Target Neighborhood Hits	956	Shared Neighborhood Hits	193
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAZ2A_MOUSE
θ value	0.62314 (rank : 207)	NC score	0.045068 (rank : 452)
Query Neighborhood Hits	409	Target Neighborhood Hits	744	Shared Neighborhood Hits	72
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BBX_MOUSE
θ value	0.62314 (rank : 208)	NC score	0.020812 (rank : 520)
Query Neighborhood Hits	409	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW5, Q3TZK1, Q6NXY8, Q6PEU3, Q8BQJ7, Q8C7E0, Q8CDQ0, Q8CDV1, Q8VI48, Q8VI49, Q8VI50, Q9CS94	Gene names	Bbx, Hbp2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).

COBA1_HUMAN
θ value	0.62314 (rank : 209)	NC score	0.009914 (rank : 563)
Query Neighborhood Hits	409	Target Neighborhood Hits	491	Shared Neighborhood Hits	21
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COX10_MOUSE
θ value	0.62314 (rank : 210)	NC score	0.031873 (rank : 482)
Query Neighborhood Hits	409	Target Neighborhood Hits	39	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFY5	Gene names	Cox10
Domain Architecture	No domain graphic available
Description	Protoheme IX farnesyltransferase, mitochondrial precursor (EC 2.5.1.-) (Heme O synthase).

ES8L3_MOUSE
θ value	0.62314 (rank : 211)	NC score	0.287683 (rank : 121)
Query Neighborhood Hits	409	Target Neighborhood Hits	168	Shared Neighborhood Hits	140
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HLX1_HUMAN
θ value	0.62314 (rank : 212)	NC score	0.005442 (rank : 575)
Query Neighborhood Hits	409	Target Neighborhood Hits	370	Shared Neighborhood Hits	7
SwissProt Accessions	Q14774, Q15988	Gene names	HLX1
Domain Architecture
Description	Homeobox protein HLX1 (Homeobox protein HB24).

IASPP_MOUSE
θ value	0.62314 (rank : 213)	NC score	0.246628 (rank : 137)
Query Neighborhood Hits	409	Target Neighborhood Hits	1024	Shared Neighborhood Hits	203
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LCK_MOUSE
θ value	0.62314 (rank : 214)	NC score	0.120412 (rank : 247)
Query Neighborhood Hits	409	Target Neighborhood Hits	981	Shared Neighborhood Hits	132
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_HUMAN
θ value	0.62314 (rank : 215)	NC score	0.138210 (rank : 220)
Query Neighborhood Hits	409	Target Neighborhood Hits	1022	Shared Neighborhood Hits	170
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MYT1_HUMAN
θ value	0.62314 (rank : 216)	NC score	0.022573 (rank : 514)
Query Neighborhood Hits	409	Target Neighborhood Hits	475	Shared Neighborhood Hits	25
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

PPRB_MOUSE
θ value	0.62314 (rank : 217)	NC score	0.042478 (rank : 457)
Query Neighborhood Hits	409	Target Neighborhood Hits	354	Shared Neighborhood Hits	42
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

RUSC2_HUMAN
θ value	0.62314 (rank : 218)	NC score	0.133215 (rank : 226)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TACC2_HUMAN
θ value	0.62314 (rank : 219)	NC score	0.051939 (rank : 432)
Query Neighborhood Hits	409	Target Neighborhood Hits	856	Shared Neighborhood Hits	76
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

EPS8_MOUSE
θ value	0.813845 (rank : 220)	NC score	0.217799 (rank : 153)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	122
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

GOGA4_HUMAN
θ value	0.813845 (rank : 221)	NC score	0.038573 (rank : 464)
Query Neighborhood Hits	409	Target Neighborhood Hits	2034	Shared Neighborhood Hits	96
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

LCK_HUMAN
θ value	0.813845 (rank : 222)	NC score	0.121405 (rank : 243)
Query Neighborhood Hits	409	Target Neighborhood Hits	987	Shared Neighborhood Hits	133
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

MAST4_HUMAN
θ value	0.813845 (rank : 223)	NC score	0.025504 (rank : 497)
Query Neighborhood Hits	409	Target Neighborhood Hits	1804	Shared Neighborhood Hits	137
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PCLO_MOUSE
θ value	0.813845 (rank : 224)	NC score	0.061929 (rank : 389)
Query Neighborhood Hits	409	Target Neighborhood Hits	2275	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RUSC1_HUMAN
θ value	0.813845 (rank : 225)	NC score	0.299287 (rank : 116)
Query Neighborhood Hits	409	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SRRM2_HUMAN
θ value	0.813845 (rank : 226)	NC score	0.069547 (rank : 367)
Query Neighborhood Hits	409	Target Neighborhood Hits	1296	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

AFF4_HUMAN
θ value	1.06291 (rank : 227)	NC score	0.055102 (rank : 411)
Query Neighborhood Hits	409	Target Neighborhood Hits	611	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

ANM2_MOUSE
θ value	1.06291 (rank : 228)	NC score	0.261785 (rank : 130)
Query Neighborhood Hits	409	Target Neighborhood Hits	175	Shared Neighborhood Hits	143
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ATF2_MOUSE
θ value	1.06291 (rank : 229)	NC score	0.023998 (rank : 503)
Query Neighborhood Hits	409	Target Neighborhood Hits	397	Shared Neighborhood Hits	27
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

DHX16_HUMAN
θ value	1.06291 (rank : 230)	NC score	0.017551 (rank : 528)
Query Neighborhood Hits	409	Target Neighborhood Hits	356	Shared Neighborhood Hits	21
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

EM55_HUMAN
θ value	1.06291 (rank : 231)	NC score	0.128419 (rank : 234)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	96
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EP400_MOUSE
θ value	1.06291 (rank : 232)	NC score	0.022083 (rank : 515)
Query Neighborhood Hits	409	Target Neighborhood Hits	592	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

ERC2_MOUSE
θ value	1.06291 (rank : 233)	NC score	0.038927 (rank : 461)
Query Neighborhood Hits	409	Target Neighborhood Hits	1166	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

FXR2_HUMAN
θ value	1.06291 (rank : 234)	NC score	0.021804 (rank : 516)
Query Neighborhood Hits	409	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

FXR2_MOUSE
θ value	1.06291 (rank : 235)	NC score	0.022976 (rank : 510)
Query Neighborhood Hits	409	Target Neighborhood Hits	66	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

IASPP_HUMAN
θ value	1.06291 (rank : 236)	NC score	0.266665 (rank : 129)
Query Neighborhood Hits	409	Target Neighborhood Hits	688	Shared Neighborhood Hits	181
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IL16_HUMAN
θ value	1.06291 (rank : 237)	NC score	0.017223 (rank : 531)
Query Neighborhood Hits	409	Target Neighborhood Hits	207	Shared Neighborhood Hits	20
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

MATK_MOUSE
θ value	1.06291 (rank : 238)	NC score	0.093214 (rank : 302)
Query Neighborhood Hits	409	Target Neighborhood Hits	952	Shared Neighborhood Hits	96
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MOR2B_MOUSE
θ value	1.06291 (rank : 239)	NC score	0.015858 (rank : 539)
Query Neighborhood Hits	409	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C5W4, Q8CG24	Gene names	Morc2b, Tce6
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2B (TCE6).

PCLO_HUMAN
θ value	1.06291 (rank : 240)	NC score	0.074047 (rank : 350)
Query Neighborhood Hits	409	Target Neighborhood Hits	2046	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PO6F2_HUMAN
θ value	1.06291 (rank : 241)	NC score	0.017174 (rank : 533)
Query Neighborhood Hits	409	Target Neighborhood Hits	618	Shared Neighborhood Hits	39
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

STAC3_HUMAN
θ value	1.06291 (rank : 242)	NC score	0.430596 (rank : 82)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	146
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	1.06291 (rank : 243)	NC score	0.433462 (rank : 80)
Query Neighborhood Hits	409	Target Neighborhood Hits	232	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TGON2_HUMAN
θ value	1.06291 (rank : 244)	NC score	0.053754 (rank : 420)
Query Neighborhood Hits	409	Target Neighborhood Hits	1037	Shared Neighborhood Hits	89
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

AFF1_HUMAN
θ value	1.38821 (rank : 245)	NC score	0.057592 (rank : 404)
Query Neighborhood Hits	409	Target Neighborhood Hits	506	Shared Neighborhood Hits	50
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

ERC2_HUMAN
θ value	1.38821 (rank : 246)	NC score	0.035269 (rank : 472)
Query Neighborhood Hits	409	Target Neighborhood Hits	1156	Shared Neighborhood Hits	53
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

GON4L_MOUSE
θ value	1.38821 (rank : 247)	NC score	0.038693 (rank : 462)
Query Neighborhood Hits	409	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

PAPPA_HUMAN
θ value	1.38821 (rank : 248)	NC score	0.011252 (rank : 556)
Query Neighborhood Hits	409	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

RIMS1_HUMAN
θ value	1.38821 (rank : 249)	NC score	0.032383 (rank : 481)
Query Neighborhood Hits	409	Target Neighborhood Hits	437	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

S3TC2_HUMAN
θ value	1.38821 (rank : 250)	NC score	0.069490 (rank : 368)
Query Neighborhood Hits	409	Target Neighborhood Hits	70	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

SHAN1_HUMAN
θ value	1.38821 (rank : 251)	NC score	0.168536 (rank : 189)
Query Neighborhood Hits	409	Target Neighborhood Hits	1041	Shared Neighborhood Hits	179
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SLY_HUMAN
θ value	1.38821 (rank : 252)	NC score	0.162283 (rank : 197)
Query Neighborhood Hits	409	Target Neighborhood Hits	81	Shared Neighborhood Hits	55
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SRMS_MOUSE
θ value	1.38821 (rank : 253)	NC score	0.097889 (rank : 296)
Query Neighborhood Hits	409	Target Neighborhood Hits	964	Shared Neighborhood Hits	117
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SYEP_HUMAN
θ value	1.38821 (rank : 254)	NC score	0.023995 (rank : 504)
Query Neighborhood Hits	409	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

ZEP2_HUMAN
θ value	1.38821 (rank : 255)	NC score	0.005227 (rank : 576)
Query Neighborhood Hits	409	Target Neighborhood Hits	937	Shared Neighborhood Hits	43
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

ZN319_HUMAN
θ value	1.38821 (rank : 256)	NC score	-0.005877 (rank : 597)
Query Neighborhood Hits	409	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2F9	Gene names	ZNF319, KIAA1388
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ARHG9_HUMAN
θ value	1.81305 (rank : 257)	NC score	0.340671 (rank : 102)
Query Neighborhood Hits	409	Target Neighborhood Hits	235	Shared Neighborhood Hits	153
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	1.81305 (rank : 258)	NC score	0.340531 (rank : 103)
Query Neighborhood Hits	409	Target Neighborhood Hits	234	Shared Neighborhood Hits	152
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

BRD4_HUMAN
θ value	1.81305 (rank : 259)	NC score	0.043347 (rank : 455)
Query Neighborhood Hits	409	Target Neighborhood Hits	851	Shared Neighborhood Hits	72
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

EM55_MOUSE
θ value	1.81305 (rank : 260)	NC score	0.123815 (rank : 238)
Query Neighborhood Hits	409	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

K0460_MOUSE
θ value	1.81305 (rank : 261)	NC score	0.035385 (rank : 471)
Query Neighborhood Hits	409	Target Neighborhood Hits	374	Shared Neighborhood Hits	41
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

M3K3_HUMAN
θ value	1.81305 (rank : 262)	NC score	0.028482 (rank : 488)
Query Neighborhood Hits	409	Target Neighborhood Hits	885	Shared Neighborhood Hits	55
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MKL1_HUMAN
θ value	1.81305 (rank : 263)	NC score	0.041880 (rank : 458)
Query Neighborhood Hits	409	Target Neighborhood Hits	232	Shared Neighborhood Hits	28
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

NOP14_HUMAN
θ value	1.81305 (rank : 264)	NC score	0.033077 (rank : 478)
Query Neighborhood Hits	409	Target Neighborhood Hits	573	Shared Neighborhood Hits	30
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

RIMB2_HUMAN
θ value	1.81305 (rank : 265)	NC score	0.319178 (rank : 111)
Query Neighborhood Hits	409	Target Neighborhood Hits	263	Shared Neighborhood Hits	124
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RPGR_HUMAN
θ value	1.81305 (rank : 266)	NC score	0.021284 (rank : 518)
Query Neighborhood Hits	409	Target Neighborhood Hits	279	Shared Neighborhood Hits	27
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

TBCD2_HUMAN
θ value	1.81305 (rank : 267)	NC score	0.016517 (rank : 535)
Query Neighborhood Hits	409	Target Neighborhood Hits	419	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

TXK_HUMAN
θ value	1.81305 (rank : 268)	NC score	0.119075 (rank : 250)
Query Neighborhood Hits	409	Target Neighborhood Hits	971	Shared Neighborhood Hits	141
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

3BP1_HUMAN
θ value	2.36792 (rank : 269)	NC score	0.090617 (rank : 310)
Query Neighborhood Hits	409	Target Neighborhood Hits	376	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AMPH_HUMAN
θ value	2.36792 (rank : 270)	NC score	0.195697 (rank : 164)
Query Neighborhood Hits	409	Target Neighborhood Hits	455	Shared Neighborhood Hits	117
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ANKS6_MOUSE
θ value	2.36792 (rank : 271)	NC score	0.021768 (rank : 517)
Query Neighborhood Hits	409	Target Neighborhood Hits	435	Shared Neighborhood Hits	29
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ATF2_HUMAN
θ value	2.36792 (rank : 272)	NC score	0.022807 (rank : 512)
Query Neighborhood Hits	409	Target Neighborhood Hits	402	Shared Neighborhood Hits	27
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

BI2L1_MOUSE
θ value	2.36792 (rank : 273)	NC score	0.157982 (rank : 203)
Query Neighborhood Hits	409	Target Neighborhood Hits	197	Shared Neighborhood Hits	69
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CTTB2_HUMAN
θ value	2.36792 (rank : 274)	NC score	0.023567 (rank : 507)
Query Neighborhood Hits	409	Target Neighborhood Hits	1061	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

DUS16_HUMAN
θ value	2.36792 (rank : 275)	NC score	0.007655 (rank : 566)
Query Neighborhood Hits	409	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

EF1D_MOUSE
θ value	2.36792 (rank : 276)	NC score	0.023934 (rank : 505)
Query Neighborhood Hits	409	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	P57776, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5	Gene names	Eef1d
Domain Architecture
Description	Elongation factor 1-delta (EF-1-delta).

GTF2I_MOUSE
θ value	2.36792 (rank : 277)	NC score	0.016695 (rank : 534)
Query Neighborhood Hits	409	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ESZ8, O54700, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9	Gene names	Gtf2i, Bap135, Diws1t
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135).

K0427_MOUSE
θ value	2.36792 (rank : 278)	NC score	0.017316 (rank : 530)
Query Neighborhood Hits	409	Target Neighborhood Hits	106	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PEE2	Gene names	Gm672
Domain Architecture	No domain graphic available
Description	Protein KIAA0427 homolog.

K1949_MOUSE
θ value	2.36792 (rank : 279)	NC score	0.024534 (rank : 499)
Query Neighborhood Hits	409	Target Neighborhood Hits	134	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

S12A6_MOUSE
θ value	2.36792 (rank : 280)	NC score	0.006930 (rank : 572)
Query Neighborhood Hits	409	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

SFR15_HUMAN
θ value	2.36792 (rank : 281)	NC score	0.031548 (rank : 483)
Query Neighborhood Hits	409	Target Neighborhood Hits	368	Shared Neighborhood Hits	28
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SRMS_HUMAN
θ value	2.36792 (rank : 282)	NC score	0.090863 (rank : 309)
Query Neighborhood Hits	409	Target Neighborhood Hits	946	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

STAR8_HUMAN
θ value	2.36792 (rank : 283)	NC score	0.048817 (rank : 447)
Query Neighborhood Hits	409	Target Neighborhood Hits	216	Shared Neighborhood Hits	32
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

TCGAP_HUMAN
θ value	2.36792 (rank : 284)	NC score	0.207679 (rank : 160)
Query Neighborhood Hits	409	Target Neighborhood Hits	872	Shared Neighborhood Hits	176
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	2.36792 (rank : 285)	NC score	0.222305 (rank : 151)
Query Neighborhood Hits	409	Target Neighborhood Hits	409	Shared Neighborhood Hits	143
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CD2L5_HUMAN
θ value	3.0926 (rank : 286)	NC score	0.026792 (rank : 492)
Query Neighborhood Hits	409	Target Neighborhood Hits	987	Shared Neighborhood Hits	64
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CENPF_HUMAN
θ value	3.0926 (rank : 287)	NC score	0.033749 (rank : 476)
Query Neighborhood Hits	409	Target Neighborhood Hits	1932	Shared Neighborhood Hits	90
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

DACH2_MOUSE
θ value	3.0926 (rank : 288)	NC score	0.015791 (rank : 540)
Query Neighborhood Hits	409	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q925Q8, Q8BMA0	Gene names	Dach2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

I20L2_HUMAN
θ value	3.0926 (rank : 289)	NC score	0.017932 (rank : 527)
Query Neighborhood Hits	409	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H9L3, Q64KA2	Gene names	ISG20L2
Domain Architecture
Description	Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-).

ICAM5_MOUSE
θ value	3.0926 (rank : 290)	NC score	0.002801 (rank : 585)
Query Neighborhood Hits	409	Target Neighborhood Hits	308	Shared Neighborhood Hits	6
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

KI67_HUMAN
θ value	3.0926 (rank : 291)	NC score	0.055928 (rank : 407)
Query Neighborhood Hits	409	Target Neighborhood Hits	581	Shared Neighborhood Hits	63
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

PP4R1_MOUSE
θ value	3.0926 (rank : 292)	NC score	0.022638 (rank : 513)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

PRG4_MOUSE
θ value	3.0926 (rank : 293)	NC score	0.040140 (rank : 459)
Query Neighborhood Hits	409	Target Neighborhood Hits	624	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RHG12_MOUSE
θ value	3.0926 (rank : 294)	NC score	0.100456 (rank : 294)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SC24B_HUMAN
θ value	3.0926 (rank : 295)	NC score	0.015127 (rank : 542)
Query Neighborhood Hits	409	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	O95487	Gene names	SEC24B
Domain Architecture
Description	Protein transport protein Sec24B (SEC24-related protein B).

SLY_MOUSE
θ value	3.0926 (rank : 296)	NC score	0.182512 (rank : 174)
Query Neighborhood Hits	409	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SPEG_HUMAN
θ value	3.0926 (rank : 297)	NC score	0.025350 (rank : 498)
Query Neighborhood Hits	409	Target Neighborhood Hits	1762	Shared Neighborhood Hits	109
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPR1B_MOUSE
θ value	3.0926 (rank : 298)	NC score	0.025556 (rank : 496)
Query Neighborhood Hits	409	Target Neighborhood Hits	395	Shared Neighborhood Hits	40
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

TIP60_HUMAN
θ value	3.0926 (rank : 299)	NC score	0.019639 (rank : 523)
Query Neighborhood Hits	409	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q92993, O95624, Q13430, Q6GSE8, Q9BWK7	Gene names	HTATIP, TIP60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60) (HIV-1 Tat interactive protein) (cPLA(2)-interacting protein).

TOX_MOUSE
θ value	3.0926 (rank : 300)	NC score	0.011922 (rank : 553)
Query Neighborhood Hits	409	Target Neighborhood Hits	95	Shared Neighborhood Hits	7
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

TTC15_MOUSE
θ value	3.0926 (rank : 301)	NC score	0.023444 (rank : 509)
Query Neighborhood Hits	409	Target Neighborhood Hits	113	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K2L8, Q8BX27	Gene names	Ttc15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

TTDN1_HUMAN
θ value	3.0926 (rank : 302)	NC score	0.022962 (rank : 511)
Query Neighborhood Hits	409	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TAP9	Gene names	TTDN1, C7orf11
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein.

ZBT11_HUMAN
θ value	3.0926 (rank : 303)	NC score	-0.005785 (rank : 596)
Query Neighborhood Hits	409	Target Neighborhood Hits	873	Shared Neighborhood Hits	19
SwissProt Accessions	O95625	Gene names	ZBTB11
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 11.

ZO1_HUMAN
θ value	3.0926 (rank : 304)	NC score	0.020467 (rank : 522)
Query Neighborhood Hits	409	Target Neighborhood Hits	474	Shared Neighborhood Hits	58
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ABL1_HUMAN
θ value	4.03905 (rank : 305)	NC score	0.115826 (rank : 256)
Query Neighborhood Hits	409	Target Neighborhood Hits	1220	Shared Neighborhood Hits	164
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ADA19_HUMAN
θ value	4.03905 (rank : 306)	NC score	0.001426 (rank : 589)
Query Neighborhood Hits	409	Target Neighborhood Hits	381	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

AFF1_MOUSE
θ value	4.03905 (rank : 307)	NC score	0.047045 (rank : 449)
Query Neighborhood Hits	409	Target Neighborhood Hits	351	Shared Neighborhood Hits	47
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

BSN_MOUSE
θ value	4.03905 (rank : 308)	NC score	0.052145 (rank : 430)
Query Neighborhood Hits	409	Target Neighborhood Hits	2057	Shared Neighborhood Hits	148
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CSKP_MOUSE
θ value	4.03905 (rank : 309)	NC score	0.054264 (rank : 413)
Query Neighborhood Hits	409	Target Neighborhood Hits	1027	Shared Neighborhood Hits	138
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DMXL1_HUMAN
θ value	4.03905 (rank : 310)	NC score	0.006138 (rank : 573)
Query Neighborhood Hits	409	Target Neighborhood Hits	259	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

DNL1_HUMAN
θ value	4.03905 (rank : 311)	NC score	0.026533 (rank : 494)
Query Neighborhood Hits	409	Target Neighborhood Hits	216	Shared Neighborhood Hits	29
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

EAF2_MOUSE
θ value	4.03905 (rank : 312)	NC score	0.014343 (rank : 545)
Query Neighborhood Hits	409	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q91ZD6, Q7TN80, Q99KD2	Gene names	Eaf2, Festa, Traits
Domain Architecture	No domain graphic available
Description	ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein) (Ehrlich S-II transcriptional activator factor).

GIT2_MOUSE
θ value	4.03905 (rank : 313)	NC score	0.016358 (rank : 537)
Query Neighborhood Hits	409	Target Neighborhood Hits	323	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GON4L_HUMAN
θ value	4.03905 (rank : 314)	NC score	0.035244 (rank : 473)
Query Neighborhood Hits	409	Target Neighborhood Hits	555	Shared Neighborhood Hits	48
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

K1914_HUMAN
θ value	4.03905 (rank : 315)	NC score	0.014181 (rank : 548)
Query Neighborhood Hits	409	Target Neighborhood Hits	255	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

KIRR3_HUMAN
θ value	4.03905 (rank : 316)	NC score	0.004757 (rank : 578)
Query Neighborhood Hits	409	Target Neighborhood Hits	302	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

KIRR3_MOUSE
θ value	4.03905 (rank : 317)	NC score	0.004927 (rank : 577)
Query Neighborhood Hits	409	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

MAP9_MOUSE
θ value	4.03905 (rank : 318)	NC score	0.030485 (rank : 484)
Query Neighborhood Hits	409	Target Neighborhood Hits	529	Shared Neighborhood Hits	37
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

PHLB1_MOUSE
θ value	4.03905 (rank : 319)	NC score	0.018382 (rank : 525)
Query Neighborhood Hits	409	Target Neighborhood Hits	678	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLXB1_HUMAN
θ value	4.03905 (rank : 320)	NC score	0.008592 (rank : 565)
Query Neighborhood Hits	409	Target Neighborhood Hits	360	Shared Neighborhood Hits	25
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

PTK6_HUMAN
θ value	4.03905 (rank : 321)	NC score	0.116853 (rank : 254)
Query Neighborhood Hits	409	Target Neighborhood Hits	1020	Shared Neighborhood Hits	165
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RERE_MOUSE
θ value	4.03905 (rank : 322)	NC score	0.038114 (rank : 465)
Query Neighborhood Hits	409	Target Neighborhood Hits	785	Shared Neighborhood Hits	71
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SHAN2_MOUSE
θ value	4.03905 (rank : 323)	NC score	0.207351 (rank : 161)
Query Neighborhood Hits	409	Target Neighborhood Hits	446	Shared Neighborhood Hits	120
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SYAP1_MOUSE
θ value	4.03905 (rank : 324)	NC score	0.026904 (rank : 490)
Query Neighborhood Hits	409	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D5V6, Q3UI67, Q9D870	Gene names	Syap1
Domain Architecture
Description	Synapse-associated protein 1.

SYNJ1_MOUSE
θ value	4.03905 (rank : 325)	NC score	0.026801 (rank : 491)
Query Neighborhood Hits	409	Target Neighborhood Hits	516	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TCOF_MOUSE
θ value	4.03905 (rank : 326)	NC score	0.055233 (rank : 410)
Query Neighborhood Hits	409	Target Neighborhood Hits	471	Shared Neighborhood Hits	47
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TIP60_MOUSE
θ value	4.03905 (rank : 327)	NC score	0.018808 (rank : 524)
Query Neighborhood Hits	409	Target Neighborhood Hits	95	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CHK4, Q8CGZ3, Q8CGZ4, Q8VIH0	Gene names	Htatip, Tip60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60).

TNC6B_HUMAN
θ value	4.03905 (rank : 328)	NC score	0.016396 (rank : 536)
Query Neighborhood Hits	409	Target Neighborhood Hits	256	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

AMPH_MOUSE
θ value	5.27518 (rank : 329)	NC score	0.180310 (rank : 175)
Query Neighborhood Hits	409	Target Neighborhood Hits	291	Shared Neighborhood Hits	92
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANKS1_MOUSE
θ value	5.27518 (rank : 330)	NC score	0.020521 (rank : 521)
Query Neighborhood Hits	409	Target Neighborhood Hits	453	Shared Neighborhood Hits	36
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANR11_HUMAN
θ value	5.27518 (rank : 331)	NC score	0.035675 (rank : 470)
Query Neighborhood Hits	409	Target Neighborhood Hits	1289	Shared Neighborhood Hits	97
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

AUTS2_HUMAN
θ value	5.27518 (rank : 332)	NC score	0.032456 (rank : 480)
Query Neighborhood Hits	409	Target Neighborhood Hits	342	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

BAZ2A_HUMAN
θ value	5.27518 (rank : 333)	NC score	0.033669 (rank : 477)
Query Neighborhood Hits	409	Target Neighborhood Hits	780	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BRWD1_MOUSE
θ value	5.27518 (rank : 334)	NC score	0.011638 (rank : 555)
Query Neighborhood Hits	409	Target Neighborhood Hits	478	Shared Neighborhood Hits	22
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

CSKP_HUMAN
θ value	5.27518 (rank : 335)	NC score	0.054750 (rank : 412)
Query Neighborhood Hits	409	Target Neighborhood Hits	1022	Shared Neighborhood Hits	132
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DOCK2_HUMAN
θ value	5.27518 (rank : 336)	NC score	0.097165 (rank : 298)
Query Neighborhood Hits	409	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

ES8L1_HUMAN
θ value	5.27518 (rank : 337)	NC score	0.185152 (rank : 173)
Query Neighborhood Hits	409	Target Neighborhood Hits	162	Shared Neighborhood Hits	108
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

GRAM3_MOUSE
θ value	5.27518 (rank : 338)	NC score	0.014326 (rank : 546)
Query Neighborhood Hits	409	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PEM6	Gene names	Gramd3
Domain Architecture	No domain graphic available
Description	GRAM domain-containing protein 3.

INADL_HUMAN
θ value	5.27518 (rank : 339)	NC score	0.007317 (rank : 570)
Query Neighborhood Hits	409	Target Neighborhood Hits	260	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

JHD3A_HUMAN
θ value	5.27518 (rank : 340)	NC score	0.007526 (rank : 568)
Query Neighborhood Hits	409	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	O75164, Q5VVB1	Gene names	JMJD2A, JHDM3A, JMJD2, KIAA0677
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

MITF_HUMAN
θ value	5.27518 (rank : 341)	NC score	0.010557 (rank : 558)
Query Neighborhood Hits	409	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MPP5_HUMAN
θ value	5.27518 (rank : 342)	NC score	0.085452 (rank : 322)
Query Neighborhood Hits	409	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	5.27518 (rank : 343)	NC score	0.084692 (rank : 324)
Query Neighborhood Hits	409	Target Neighborhood Hits	226	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

NKX61_MOUSE
θ value	5.27518 (rank : 344)	NC score	0.002822 (rank : 584)
Query Neighborhood Hits	409	Target Neighborhood Hits	439	Shared Neighborhood Hits	16
SwissProt Accessions	Q99MA9, Q9ERQ7	Gene names	Nkx6-1, Nkx6.1, Nkx6a
Domain Architecture
Description	Homeobox protein Nkx-6.1.

PEX13_MOUSE
θ value	5.27518 (rank : 345)	NC score	0.324242 (rank : 108)
Query Neighborhood Hits	409	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RERE_HUMAN
θ value	5.27518 (rank : 346)	NC score	0.038692 (rank : 463)
Query Neighborhood Hits	409	Target Neighborhood Hits	779	Shared Neighborhood Hits	69
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RUSC1_MOUSE
θ value	5.27518 (rank : 347)	NC score	0.273473 (rank : 126)
Query Neighborhood Hits	409	Target Neighborhood Hits	206	Shared Neighborhood Hits	134
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SASH1_HUMAN
θ value	5.27518 (rank : 348)	NC score	0.111765 (rank : 266)
Query Neighborhood Hits	409	Target Neighborhood Hits	292	Shared Neighborhood Hits	73
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	5.27518 (rank : 349)	NC score	0.108195 (rank : 277)
Query Neighborhood Hits	409	Target Neighborhood Hits	263	Shared Neighborhood Hits	76
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

TEC_MOUSE
θ value	5.27518 (rank : 350)	NC score	0.115365 (rank : 259)
Query Neighborhood Hits	409	Target Neighborhood Hits	1006	Shared Neighborhood Hits	152
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TMCC2_HUMAN
θ value	5.27518 (rank : 351)	NC score	0.012894 (rank : 551)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	14
SwissProt Accessions	O75069, Q6ZN09	Gene names	TMCC2, KIAA0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11).

WIRE_MOUSE
θ value	5.27518 (rank : 352)	NC score	0.034358 (rank : 474)
Query Neighborhood Hits	409	Target Neighborhood Hits	310	Shared Neighborhood Hits	37
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

WNK2_HUMAN
θ value	5.27518 (rank : 353)	NC score	0.036277 (rank : 468)
Query Neighborhood Hits	409	Target Neighborhood Hits	1407	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZN133_HUMAN
θ value	5.27518 (rank : 354)	NC score	-0.007027 (rank : 599)
Query Neighborhood Hits	409	Target Neighborhood Hits	784	Shared Neighborhood Hits	16
SwissProt Accessions	P52736, Q9BUV2, Q9H443	Gene names	ZNF133
Domain Architecture
Description	Zinc finger protein 133.

ZN596_HUMAN
θ value	5.27518 (rank : 355)	NC score	-0.007016 (rank : 598)
Query Neighborhood Hits	409	Target Neighborhood Hits	716	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TC21, O95015, Q8N9X0	Gene names	ZNF596
Domain Architecture	No domain graphic available
Description	Zinc finger protein 596.

5NT1B_MOUSE
θ value	6.88961 (rank : 356)	NC score	0.012202 (rank : 552)
Query Neighborhood Hits	409	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YE9, Q91Y48	Gene names	Nt5c1b, Airp
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

ACK1_HUMAN
θ value	6.88961 (rank : 357)	NC score	0.063814 (rank : 382)
Query Neighborhood Hits	409	Target Neighborhood Hits	1140	Shared Neighborhood Hits	107
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	6.88961 (rank : 358)	NC score	0.064916 (rank : 379)
Query Neighborhood Hits	409	Target Neighborhood Hits	1080	Shared Neighborhood Hits	110
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AMACR_MOUSE
θ value	6.88961 (rank : 359)	NC score	0.010341 (rank : 559)
Query Neighborhood Hits	409	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O09174, Q9DCW6	Gene names	Amacr, Macr1
Domain Architecture
Description	Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase).

ARNT_HUMAN
θ value	6.88961 (rank : 360)	NC score	0.014609 (rank : 544)
Query Neighborhood Hits	409	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CBL_MOUSE
θ value	6.88961 (rank : 361)	NC score	0.017209 (rank : 532)
Query Neighborhood Hits	409	Target Neighborhood Hits	426	Shared Neighborhood Hits	35
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

CN155_HUMAN
θ value	6.88961 (rank : 362)	NC score	0.047910 (rank : 448)
Query Neighborhood Hits	409	Target Neighborhood Hits	385	Shared Neighborhood Hits	45
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CO039_MOUSE
θ value	6.88961 (rank : 363)	NC score	0.028846 (rank : 487)
Query Neighborhood Hits	409	Target Neighborhood Hits	445	Shared Neighborhood Hits	58
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CO5A1_HUMAN
θ value	6.88961 (rank : 364)	NC score	0.009963 (rank : 562)
Query Neighborhood Hits	409	Target Neighborhood Hits	434	Shared Neighborhood Hits	28
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

COBA1_MOUSE
θ value	6.88961 (rank : 365)	NC score	0.007337 (rank : 569)
Query Neighborhood Hits	409	Target Neighborhood Hits	487	Shared Neighborhood Hits	22
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CTRO_HUMAN
θ value	6.88961 (rank : 366)	NC score	0.028302 (rank : 489)
Query Neighborhood Hits	409	Target Neighborhood Hits	2092	Shared Neighborhood Hits	103
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DDX46_HUMAN
θ value	6.88961 (rank : 367)	NC score	0.003333 (rank : 581)
Query Neighborhood Hits	409	Target Neighborhood Hits	357	Shared Neighborhood Hits	21
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

GGN_HUMAN
θ value	6.88961 (rank : 368)	NC score	0.035928 (rank : 469)
Query Neighborhood Hits	409	Target Neighborhood Hits	269	Shared Neighborhood Hits	34
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

H12_HUMAN
θ value	6.88961 (rank : 369)	NC score	0.010049 (rank : 561)
Query Neighborhood Hits	409	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	P16403	Gene names	HIST1H1C, H1F2
Domain Architecture
Description	Histone H1.2 (Histone H1d).

HXA3_HUMAN
θ value	6.88961 (rank : 370)	NC score	0.002111 (rank : 588)
Query Neighborhood Hits	409	Target Neighborhood Hits	535	Shared Neighborhood Hits	30
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

JHD3A_MOUSE
θ value	6.88961 (rank : 371)	NC score	0.006966 (rank : 571)
Query Neighborhood Hits	409	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BW72, Q3UKM5, Q3UM81, Q3UWV2, Q6ZQ72, Q8K137	Gene names	Jmjd2a, Jhdm3a, Jmjd2, Kiaa0677
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

K1267_MOUSE
θ value	6.88961 (rank : 372)	NC score	0.011748 (rank : 554)
Query Neighborhood Hits	409	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TG1, Q3TT88, Q3U5D8, Q3V3N3, Q7TMU3, Q80XP7, Q8R3L6, Q9D9G0	Gene names	Kiaa1267
Domain Architecture	No domain graphic available
Description	Protein KIAA1267.

MPP6_HUMAN
θ value	6.88961 (rank : 373)	NC score	0.107841 (rank : 280)
Query Neighborhood Hits	409	Target Neighborhood Hits	180	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	6.88961 (rank : 374)	NC score	0.102831 (rank : 291)
Query Neighborhood Hits	409	Target Neighborhood Hits	187	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MUC1_MOUSE
θ value	6.88961 (rank : 375)	NC score	0.021066 (rank : 519)
Query Neighborhood Hits	409	Target Neighborhood Hits	388	Shared Neighborhood Hits	28
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

NCOA1_HUMAN
θ value	6.88961 (rank : 376)	NC score	0.010232 (rank : 560)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

PHLA1_HUMAN
θ value	6.88961 (rank : 377)	NC score	0.013321 (rank : 550)
Query Neighborhood Hits	409	Target Neighborhood Hits	121	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

PRDM1_MOUSE
θ value	6.88961 (rank : 378)	NC score	-0.004428 (rank : 595)
Query Neighborhood Hits	409	Target Neighborhood Hits	766	Shared Neighborhood Hits	14
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

RAD54_HUMAN
θ value	6.88961 (rank : 379)	NC score	0.003638 (rank : 579)
Query Neighborhood Hits	409	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q92698, Q6IUY3	Gene names	RAD54L, RAD54A
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54-like (EC 3.6.1.-) (RAD54 homolog) (hRAD54) (hHR54).

RBM6_HUMAN
θ value	6.88961 (rank : 380)	NC score	0.014311 (rank : 547)
Query Neighborhood Hits	409	Target Neighborhood Hits	221	Shared Neighborhood Hits	15
SwissProt Accessions	P78332, O60549, O75524	Gene names	RBM6, DEF3
Domain Architecture
Description	RNA-binding protein 6 (RNA-binding motif protein 6) (RNA-binding protein DEF-3) (Lung cancer antigen NY-LU-12) (Protein G16).

RHG12_HUMAN
θ value	6.88961 (rank : 381)	NC score	0.091300 (rank : 306)
Query Neighborhood Hits	409	Target Neighborhood Hits	190	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

THIKB_MOUSE
θ value	6.88961 (rank : 382)	NC score	0.005948 (rank : 574)
Query Neighborhood Hits	409	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCH0	Gene names	Acaa1b, Acaa1
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase B, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl- CoA thiolase B).

TRIPC_HUMAN
θ value	6.88961 (rank : 383)	NC score	0.014671 (rank : 543)
Query Neighborhood Hits	409	Target Neighborhood Hits	319	Shared Neighborhood Hits	33
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

TTC15_HUMAN
θ value	6.88961 (rank : 384)	NC score	0.024021 (rank : 502)
Query Neighborhood Hits	409	Target Neighborhood Hits	112	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WVT3, Q8WVW1, Q9Y395	Gene names	TTC15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

ULE1B_HUMAN
θ value	6.88961 (rank : 385)	NC score	0.007559 (rank : 567)
Query Neighborhood Hits	409	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

BC11A_HUMAN
θ value	8.99809 (rank : 386)	NC score	-0.004307 (rank : 594)
Query Neighborhood Hits	409	Target Neighborhood Hits	745	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H165, Q86W14, Q8WU92, Q96JL6, Q9H163, Q9H164, Q9H3G9, Q9NWA7	Gene names	BCL11A, CTIP1, EVI9, KIAA1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

BC11A_MOUSE
θ value	8.99809 (rank : 387)	NC score	-0.003552 (rank : 593)
Query Neighborhood Hits	409	Target Neighborhood Hits	732	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QYE3, Q80T89, Q8BLC7, Q8BLR4, Q8BWX3, Q921V4, Q9D0V2, Q9JIT4, Q9JLK8, Q9JLK9	Gene names	Bcl11a, Ctip1, Evi9, Kiaa1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

BIG2_HUMAN
θ value	8.99809 (rank : 388)	NC score	0.003277 (rank : 582)
Query Neighborhood Hits	409	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CD2L5_MOUSE
θ value	8.99809 (rank : 389)	NC score	0.026543 (rank : 493)
Query Neighborhood Hits	409	Target Neighborhood Hits	1011	Shared Neighborhood Hits	70
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

DACH2_HUMAN
θ value	8.99809 (rank : 390)	NC score	0.011160 (rank : 557)
Query Neighborhood Hits	409	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	Q96NX9, Q8NAY3, Q8ND17, Q96N55	Gene names	DACH2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

DPOLZ_HUMAN
θ value	8.99809 (rank : 391)	NC score	0.013834 (rank : 549)
Query Neighborhood Hits	409	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

ERN1_MOUSE
θ value	8.99809 (rank : 392)	NC score	0.017996 (rank : 526)
Query Neighborhood Hits	409	Target Neighborhood Hits	823	Shared Neighborhood Hits	46
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ES8L2_HUMAN
θ value	8.99809 (rank : 393)	NC score	0.204794 (rank : 163)
Query Neighborhood Hits	409	Target Neighborhood Hits	193	Shared Neighborhood Hits	129
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

LIPS_HUMAN
θ value	8.99809 (rank : 394)	NC score	0.023544 (rank : 508)
Query Neighborhood Hits	409	Target Neighborhood Hits	314	Shared Neighborhood Hits	42
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

MAGD2_HUMAN
θ value	8.99809 (rank : 395)	NC score	0.003049 (rank : 583)
Query Neighborhood Hits	409	Target Neighborhood Hits	95	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UNF1, O76058, Q5BJF3, Q8NAL6, Q9H218, Q9P0U9, Q9UM52	Gene names	MAGED2, BCG1
Domain Architecture
Description	Melanoma-associated antigen D2 (MAGE-D2 antigen) (MAGE-D) (Breast cancer-associated gene 1 protein) (BCG-1) (11B6) (Hepatocellular carcinoma-associated protein JCL-1).

MAML1_MOUSE
θ value	8.99809 (rank : 396)	NC score	0.015931 (rank : 538)
Query Neighborhood Hits	409	Target Neighborhood Hits	279	Shared Neighborhood Hits	29
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MAP1A_HUMAN
θ value	8.99809 (rank : 397)	NC score	0.046482 (rank : 451)
Query Neighborhood Hits	409	Target Neighborhood Hits	1626	Shared Neighborhood Hits	106
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MAP1B_HUMAN
θ value	8.99809 (rank : 398)	NC score	0.052209 (rank : 429)
Query Neighborhood Hits	409	Target Neighborhood Hits	903	Shared Neighborhood Hits	74
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MLL3_HUMAN
θ value	8.99809 (rank : 399)	NC score	0.039988 (rank : 460)
Query Neighborhood Hits	409	Target Neighborhood Hits	1644	Shared Neighborhood Hits	111
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MUC24_HUMAN
θ value	8.99809 (rank : 400)	NC score	0.015592 (rank : 541)
Query Neighborhood Hits	409	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q04900, Q5JSU6	Gene names	CD164
Domain Architecture
Description	Putative mucin core protein 24 precursor (Multi-glycosylated core protein 24) (MGC-24) (MUC-24) (CD164 antigen).

MYCD_MOUSE
θ value	8.99809 (rank : 401)	NC score	0.023809 (rank : 506)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

NCOR2_HUMAN
θ value	8.99809 (rank : 402)	NC score	0.037892 (rank : 466)
Query Neighborhood Hits	409	Target Neighborhood Hits	870	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NKX61_HUMAN
θ value	8.99809 (rank : 403)	NC score	0.002281 (rank : 587)
Query Neighborhood Hits	409	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	P78426	Gene names	NKX6-1, NKX6A
Domain Architecture
Description	Homeobox protein Nkx-6.1.

NMDE4_MOUSE
θ value	8.99809 (rank : 404)	NC score	0.003419 (rank : 580)
Query Neighborhood Hits	409	Target Neighborhood Hits	158	Shared Neighborhood Hits	16
SwissProt Accessions	Q03391	Gene names	Grin2d
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D).

SGOL2_HUMAN
θ value	8.99809 (rank : 405)	NC score	0.009432 (rank : 564)
Query Neighborhood Hits	409	Target Neighborhood Hits	207	Shared Neighborhood Hits	11
SwissProt Accessions	Q562F6, Q53RR9, Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3	Gene names	SGOL2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2 (Tripin).

SREC2_HUMAN
θ value	8.99809 (rank : 406)	NC score	0.000993 (rank : 590)
Query Neighborhood Hits	409	Target Neighborhood Hits	645	Shared Neighborhood Hits	24
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

TEC_HUMAN
θ value	8.99809 (rank : 407)	NC score	0.119038 (rank : 251)
Query Neighborhood Hits	409	Target Neighborhood Hits	1006	Shared Neighborhood Hits	153
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZCH11_HUMAN
θ value	8.99809 (rank : 408)	NC score	0.017449 (rank : 529)
Query Neighborhood Hits	409	Target Neighborhood Hits	278	Shared Neighborhood Hits	31
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

ZEP2_MOUSE
θ value	8.99809 (rank : 409)	NC score	0.002443 (rank : 586)
Query Neighborhood Hits	409	Target Neighborhood Hits	964	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

3BP1_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.062571 (rank : 386)
Query Neighborhood Hits	409	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABL1_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.114432 (rank : 261)
Query Neighborhood Hits	409	Target Neighborhood Hits	1178	Shared Neighborhood Hits	156
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.110022 (rank : 272)
Query Neighborhood Hits	409	Target Neighborhood Hits	1045	Shared Neighborhood Hits	137
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.106882 (rank : 283)
Query Neighborhood Hits	409	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

APS_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.120824 (rank : 245)
Query Neighborhood Hits	409	Target Neighborhood Hits	162	Shared Neighborhood Hits	49
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.092406 (rank : 303)
Query Neighborhood Hits	409	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.131431 (rank : 230)
Query Neighborhood Hits	409	Target Neighborhood Hits	176	Shared Neighborhood Hits	31
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.122468 (rank : 241)
Query Neighborhood Hits	409	Target Neighborhood Hits	266	Shared Neighborhood Hits	31
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.108711 (rank : 276)
Query Neighborhood Hits	409	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.103614 (rank : 288)
Query Neighborhood Hits	409	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.167036 (rank : 190)
Query Neighborhood Hits	409	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.166799 (rank : 192)
Query Neighborhood Hits	409	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.291955 (rank : 119)
Query Neighborhood Hits	409	Target Neighborhood Hits	185	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG8_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.155229 (rank : 206)
Query Neighborhood Hits	409	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.164183 (rank : 194)
Query Neighborhood Hits	409	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.131894 (rank : 228)
Query Neighborhood Hits	409	Target Neighborhood Hits	187	Shared Neighborhood Hits	25
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.134131 (rank : 225)
Query Neighborhood Hits	409	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.121605 (rank : 242)
Query Neighborhood Hits	409	Target Neighborhood Hits	375	Shared Neighborhood Hits	38
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.120757 (rank : 246)
Query Neighborhood Hits	409	Target Neighborhood Hits	351	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.120838 (rank : 244)
Query Neighborhood Hits	409	Target Neighborhood Hits	344	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.140241 (rank : 218)
Query Neighborhood Hits	409	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BCAR3_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.084616 (rank : 325)
Query Neighborhood Hits	409	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.084174 (rank : 328)
Query Neighborhood Hits	409	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.120179 (rank : 248)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.164407 (rank : 193)
Query Neighborhood Hits	409	Target Neighborhood Hits	156	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BLNK_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.074438 (rank : 347)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.082827 (rank : 331)
Query Neighborhood Hits	409	Target Neighborhood Hits	296	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.067417 (rank : 373)
Query Neighborhood Hits	409	Target Neighborhood Hits	942	Shared Neighborhood Hits	68
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.067531 (rank : 372)
Query Neighborhood Hits	409	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CHIN_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.108144 (rank : 278)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.110232 (rank : 271)
Query Neighborhood Hits	409	Target Neighborhood Hits	229	Shared Neighborhood Hits	61
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.107304 (rank : 282)
Query Neighborhood Hits	409	Target Neighborhood Hits	220	Shared Neighborhood Hits	56
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.070729 (rank : 361)
Query Neighborhood Hits	409	Target Neighborhood Hits	130	Shared Neighborhood Hits	27
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.158654 (rank : 201)
Query Neighborhood Hits	409	Target Neighborhood Hits	374	Shared Neighborhood Hits	83
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CISH_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.066742 (rank : 375)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.066668 (rank : 377)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

DAPP1_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.143755 (rank : 216)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.146123 (rank : 215)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DLG2_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.050140 (rank : 445)
Query Neighborhood Hits	409	Target Neighborhood Hits	279	Shared Neighborhood Hits	75
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.051566 (rank : 435)
Query Neighborhood Hits	409	Target Neighborhood Hits	271	Shared Neighborhood Hits	75
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DOCK2_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.095312 (rank : 299)
Query Neighborhood Hits	409	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DUET_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.057786 (rank : 402)
Query Neighborhood Hits	409	Target Neighborhood Hits	1220	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.131825 (rank : 229)
Query Neighborhood Hits	409	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.136285 (rank : 224)
Query Neighborhood Hits	409	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EP15R_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.053462 (rank : 422)
Query Neighborhood Hits	409	Target Neighborhood Hits	1135	Shared Neighborhood Hits	51
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.051551 (rank : 436)
Query Neighborhood Hits	409	Target Neighborhood Hits	1021	Shared Neighborhood Hits	44
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.051210 (rank : 437)
Query Neighborhood Hits	409	Target Neighborhood Hits	820	Shared Neighborhood Hits	31
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP300_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.055397 (rank : 408)
Query Neighborhood Hits	409	Target Neighborhood Hits	821	Shared Neighborhood Hits	70
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

ES8L1_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.191724 (rank : 170)
Query Neighborhood Hits	409	Target Neighborhood Hits	143	Shared Neighborhood Hits	92
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.205016 (rank : 162)
Query Neighborhood Hits	409	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FARP1_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.072133 (rank : 357)
Query Neighborhood Hits	409	Target Neighborhood Hits	241	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.073783 (rank : 351)
Query Neighborhood Hits	409	Target Neighborhood Hits	240	Shared Neighborhood Hits	32
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.083966 (rank : 330)
Query Neighborhood Hits	409	Target Neighborhood Hits	209	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.075181 (rank : 346)
Query Neighborhood Hits	409	Target Neighborhood Hits	1278	Shared Neighborhood Hits	98
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.054058 (rank : 415)
Query Neighborhood Hits	409	Target Neighborhood Hits	978	Shared Neighborhood Hits	69
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.050750 (rank : 439)
Query Neighborhood Hits	409	Target Neighborhood Hits	980	Shared Neighborhood Hits	63
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.091521 (rank : 305)
Query Neighborhood Hits	409	Target Neighborhood Hits	367	Shared Neighborhood Hits	45
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.089298 (rank : 313)
Query Neighborhood Hits	409	Target Neighborhood Hits	387	Shared Neighborhood Hits	46
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.100271 (rank : 295)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.094798 (rank : 301)
Query Neighborhood Hits	409	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.103422 (rank : 289)
Query Neighborhood Hits	409	Target Neighborhood Hits	249	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.109490 (rank : 273)
Query Neighborhood Hits	409	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.105280 (rank : 287)
Query Neighborhood Hits	409	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.105720 (rank : 286)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.077846 (rank : 342)
Query Neighborhood Hits	409	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.088824 (rank : 314)
Query Neighborhood Hits	409	Target Neighborhood Hits	282	Shared Neighborhood Hits	44
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FYB_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.053886 (rank : 418)
Query Neighborhood Hits	409	Target Neighborhood Hits	379	Shared Neighborhood Hits	66
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GMIP_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.055270 (rank : 409)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GMIP_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.060297 (rank : 395)
Query Neighborhood Hits	409	Target Neighborhood Hits	202	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GNRP_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.107436 (rank : 281)
Query Neighborhood Hits	409	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.113130 (rank : 264)
Query Neighborhood Hits	409	Target Neighborhood Hits	191	Shared Neighborhood Hits	28
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.084008 (rank : 329)
Query Neighborhood Hits	409	Target Neighborhood Hits	147	Shared Neighborhood Hits	49
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.085596 (rank : 321)
Query Neighborhood Hits	409	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.111158 (rank : 269)
Query Neighborhood Hits	409	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.113558 (rank : 262)
Query Neighborhood Hits	409	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.090307 (rank : 311)
Query Neighborhood Hits	409	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.103142 (rank : 290)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	58
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.101432 (rank : 292)
Query Neighborhood Hits	409	Target Neighborhood Hits	350	Shared Neighborhood Hits	37
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.101265 (rank : 293)
Query Neighborhood Hits	409	Target Neighborhood Hits	159	Shared Neighborhood Hits	46
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.074431 (rank : 348)
Query Neighborhood Hits	409	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ILK1_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.053300 (rank : 424)
Query Neighborhood Hits	409	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.052921 (rank : 425)
Query Neighborhood Hits	409	Target Neighborhood Hits	848	Shared Neighborhood Hits	59
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.053543 (rank : 421)
Query Neighborhood Hits	409	Target Neighborhood Hits	858	Shared Neighborhood Hits	60
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ITK_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.105945 (rank : 285)
Query Neighborhood Hits	409	Target Neighborhood Hits	1016	Shared Neighborhood Hits	147
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.097730 (rank : 297)
Query Neighborhood Hits	409	Target Neighborhood Hits	985	Shared Neighborhood Hits	133
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KSYK_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.066703 (rank : 376)
Query Neighborhood Hits	409	Target Neighborhood Hits	901	Shared Neighborhood Hits	72
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.068141 (rank : 370)
Query Neighborhood Hits	409	Target Neighborhood Hits	944	Shared Neighborhood Hits	78
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.108031 (rank : 279)
Query Neighborhood Hits	409	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.087664 (rank : 318)
Query Neighborhood Hits	409	Target Neighborhood Hits	531	Shared Neighborhood Hits	92
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.086709 (rank : 319)
Query Neighborhood Hits	409	Target Neighborhood Hits	177	Shared Neighborhood Hits	53
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LMO7_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.052333 (rank : 428)
Query Neighborhood Hits	409	Target Neighborhood Hits	507	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LNK_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.108933 (rank : 275)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.109283 (rank : 274)
Query Neighborhood Hits	409	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MAP1B_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.052340 (rank : 427)
Query Neighborhood Hits	409	Target Neighborhood Hits	977	Shared Neighborhood Hits	76
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MATK_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.086495 (rank : 320)
Query Neighborhood Hits	409	Target Neighborhood Hits	954	Shared Neighborhood Hits	92
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MCF2L_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.151312 (rank : 209)
Query Neighborhood Hits	409	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.125379 (rank : 237)
Query Neighborhood Hits	409	Target Neighborhood Hits	166	Shared Neighborhood Hits	28
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MDC1_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.052769 (rank : 426)
Query Neighborhood Hits	409	Target Neighborhood Hits	998	Shared Neighborhood Hits	96
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MIA_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.050591 (rank : 440)
Query Neighborhood Hits	409	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.050075 (rank : 446)
Query Neighborhood Hits	409	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MPP2_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.070052 (rank : 364)
Query Neighborhood Hits	409	Target Neighborhood Hits	173	Shared Neighborhood Hits	70
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.070640 (rank : 362)
Query Neighborhood Hits	409	Target Neighborhood Hits	189	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP4_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.057216 (rank : 406)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.062724 (rank : 385)
Query Neighborhood Hits	409	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

NACAM_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.060709 (rank : 394)
Query Neighborhood Hits	409	Target Neighborhood Hits	1866	Shared Neighborhood Hits	154
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NOXO1_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.211307 (rank : 159)
Query Neighborhood Hits	409	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.290894 (rank : 120)
Query Neighborhood Hits	409	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NRAP_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.069382 (rank : 369)
Query Neighborhood Hits	409	Target Neighborhood Hits	159	Shared Neighborhood Hits	8
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.070121 (rank : 363)
Query Neighborhood Hits	409	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

OPHN1_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.061654 (rank : 391)
Query Neighborhood Hits	409	Target Neighborhood Hits	161	Shared Neighborhood Hits	31
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.058253 (rank : 399)
Query Neighborhood Hits	409	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

P55G_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.163305 (rank : 196)
Query Neighborhood Hits	409	Target Neighborhood Hits	451	Shared Neighborhood Hits	70
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.162005 (rank : 198)
Query Neighborhood Hits	409	Target Neighborhood Hits	401	Shared Neighborhood Hits	67
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PEX13_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.314465 (rank : 114)
Query Neighborhood Hits	409	Target Neighborhood Hits	128	Shared Neighborhood Hits	112
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.171122 (rank : 185)
Query Neighborhood Hits	409	Target Neighborhood Hits	174	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.071433 (rank : 360)
Query Neighborhood Hits	409	Target Neighborhood Hits	200	Shared Neighborhood Hits	21
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.084810 (rank : 323)
Query Neighborhood Hits	409	Target Neighborhood Hits	254	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.079978 (rank : 336)
Query Neighborhood Hits	409	Target Neighborhood Hits	308	Shared Neighborhood Hits	30
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.158428 (rank : 202)
Query Neighborhood Hits	409	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTK6_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.118975 (rank : 252)
Query Neighborhood Hits	409	Target Neighborhood Hits	1026	Shared Neighborhood Hits	163
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.084326 (rank : 327)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.084338 (rank : 326)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.071880 (rank : 359)
Query Neighborhood Hits	409	Target Neighborhood Hits	234	Shared Neighborhood Hits	58
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.073419 (rank : 352)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.163728 (rank : 195)
Query Neighborhood Hits	409	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

REPS1_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.062210 (rank : 388)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	29
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.059367 (rank : 397)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.072388 (rank : 355)
Query Neighborhood Hits	409	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.069736 (rank : 365)
Query Neighborhood Hits	409	Target Neighborhood Hits	102	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGAP1_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.050522 (rank : 441)
Query Neighborhood Hits	409	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGNEF_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.110378 (rank : 270)
Query Neighborhood Hits	409	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG06_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.050197 (rank : 444)
Query Neighborhood Hits	409	Target Neighborhood Hits	114	Shared Neighborhood Hits	25
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG25_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.061079 (rank : 393)
Query Neighborhood Hits	409	Target Neighborhood Hits	550	Shared Neighborhood Hits	43
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RUSC2_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.106580 (rank : 284)
Query Neighborhood Hits	409	Target Neighborhood Hits	305	Shared Neighborhood Hits	84
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

S3TC2_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.053908 (rank : 417)
Query Neighborhood Hits	409	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

SAMN1_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.094992 (rank : 300)
Query Neighborhood Hits	409	Target Neighborhood Hits	74	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.089481 (rank : 312)
Query Neighborhood Hits	409	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SH21A_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.091172 (rank : 307)
Query Neighborhood Hits	409	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.091800 (rank : 304)
Query Neighborhood Hits	409	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.126127 (rank : 236)
Query Neighborhood Hits	409	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.127956 (rank : 235)
Query Neighborhood Hits	409	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.076230 (rank : 345)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.088716 (rank : 315)
Query Neighborhood Hits	409	Target Neighborhood Hits	179	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.076661 (rank : 344)
Query Neighborhood Hits	409	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.087691 (rank : 317)
Query Neighborhood Hits	409	Target Neighborhood Hits	455	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.072829 (rank : 354)
Query Neighborhood Hits	409	Target Neighborhood Hits	326	Shared Neighborhood Hits	59
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.082643 (rank : 332)
Query Neighborhood Hits	409	Target Neighborhood Hits	188	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.088715 (rank : 316)
Query Neighborhood Hits	409	Target Neighborhood Hits	174	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.115375 (rank : 258)
Query Neighborhood Hits	409	Target Neighborhood Hits	141	Shared Neighborhood Hits	55
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.119302 (rank : 249)
Query Neighborhood Hits	409	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.115024 (rank : 260)
Query Neighborhood Hits	409	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.118312 (rank : 253)
Query Neighborhood Hits	409	Target Neighborhood Hits	180	Shared Neighborhood Hits	63
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.111295 (rank : 268)
Query Neighborhood Hits	409	Target Neighborhood Hits	170	Shared Neighborhood Hits	59
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.111704 (rank : 267)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.113029 (rank : 265)
Query Neighborhood Hits	409	Target Neighborhood Hits	155	Shared Neighborhood Hits	51
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.122563 (rank : 240)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.115772 (rank : 257)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	61
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.116479 (rank : 255)
Query Neighborhood Hits	409	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.123796 (rank : 239)
Query Neighborhood Hits	409	Target Neighborhood Hits	164	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.128989 (rank : 232)
Query Neighborhood Hits	409	Target Neighborhood Hits	169	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.170900 (rank : 186)
Query Neighborhood Hits	409	Target Neighborhood Hits	113	Shared Neighborhood Hits	53
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.169428 (rank : 187)
Query Neighborhood Hits	409	Target Neighborhood Hits	117	Shared Neighborhood Hits	54
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.192703 (rank : 166)
Query Neighborhood Hits	409	Target Neighborhood Hits	139	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.192139 (rank : 169)
Query Neighborhood Hits	409	Target Neighborhood Hits	136	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SOCS1_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.050273 (rank : 443)
Query Neighborhood Hits	409	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.050968 (rank : 438)
Query Neighborhood Hits	409	Target Neighborhood Hits	82	Shared Neighborhood Hits	29
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS2_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.074189 (rank : 349)
Query Neighborhood Hits	409	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.078252 (rank : 340)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.072231 (rank : 356)
Query Neighborhood Hits	409	Target Neighborhood Hits	126	Shared Neighborhood Hits	40
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.073191 (rank : 353)
Query Neighborhood Hits	409	Target Neighborhood Hits	146	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.078714 (rank : 338)
Query Neighborhood Hits	409	Target Neighborhood Hits	154	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOS1_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.057658 (rank : 403)
Query Neighborhood Hits	409	Target Neighborhood Hits	274	Shared Neighborhood Hits	37
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.053860 (rank : 419)
Query Neighborhood Hits	409	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.188694 (rank : 171)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.167004 (rank : 191)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRRM1_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.051858 (rank : 433)
Query Neighborhood Hits	409	Target Neighborhood Hits	690	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.057229 (rank : 405)
Query Neighborhood Hits	409	Target Neighborhood Hits	966	Shared Neighborhood Hits	103
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.063896 (rank : 381)
Query Neighborhood Hits	409	Target Neighborhood Hits	1470	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TAGAP_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.051825 (rank : 434)
Query Neighborhood Hits	409	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TARA_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.052048 (rank : 431)
Query Neighborhood Hits	409	Target Neighborhood Hits	1626	Shared Neighborhood Hits	122
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TENS4_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.064294 (rank : 380)
Query Neighborhood Hits	409	Target Neighborhood Hits	214	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 591)	NC score	0.061144 (rank : 392)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.059080 (rank : 398)
Query Neighborhood Hits	409	Target Neighborhood Hits	1103	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.060028 (rank : 396)
Query Neighborhood Hits	409	Target Neighborhood Hits	1333	Shared Neighborhood Hits	89
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIAM1_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.156762 (rank : 205)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.159252 (rank : 200)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	33
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRIO_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.071950 (rank : 358)
Query Neighborhood Hits	409	Target Neighborhood Hits	1580	Shared Neighborhood Hits	130
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TXND2_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.054224 (rank : 414)
Query Neighborhood Hits	409	Target Neighborhood Hits	793	Shared Neighborhood Hits	80
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ZAP70_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.067001 (rank : 374)
Query Neighborhood Hits	409	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 599)	NC score	0.067997 (rank : 371)
Query Neighborhood Hits	409	Target Neighborhood Hits	905	Shared Neighborhood Hits	72
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

SRBS1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	409	Target Neighborhood Hits	409	Shared Neighborhood Hits	409
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.934573 (rank : 2)	θ value	1.01238e-168 (rank : 2)
Query Neighborhood Hits	409	Target Neighborhood Hits	396	Shared Neighborhood Hits	250
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.896506 (rank : 3)	θ value	5.34618e-69 (rank : 4)
Query Neighborhood Hits	409	Target Neighborhood Hits	270	Shared Neighborhood Hits	223
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.889999 (rank : 4)	θ value	4.83544e-70 (rank : 3)
Query Neighborhood Hits	409	Target Neighborhood Hits	286	Shared Neighborhood Hits	222
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SH3K1_HUMAN
NC score	0.729191 (rank : 5)	θ value	5.25075e-16 (rank : 7)
Query Neighborhood Hits	409	Target Neighborhood Hits	341	Shared Neighborhood Hits	212
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.723064 (rank : 6)	θ value	6.85773e-16 (rank : 8)
Query Neighborhood Hits	409	Target Neighborhood Hits	332	Shared Neighborhood Hits	212
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
NC score	0.721754 (rank : 7)	θ value	1.09485e-13 (rank : 14)
Query Neighborhood Hits	409	Target Neighborhood Hits	315	Shared Neighborhood Hits	211
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.717453 (rank : 8)	θ value	7.09661e-13 (rank : 15)
Query Neighborhood Hits	409	Target Neighborhood Hits	336	Shared Neighborhood Hits	215
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NCF2_HUMAN
NC score	0.674696 (rank : 9)	θ value	6.43352e-06 (rank : 49)
Query Neighborhood Hits	409	Target Neighborhood Hits	229	Shared Neighborhood Hits	180
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G3_MOUSE
NC score	0.624539 (rank : 10)	θ value	1.17247e-07 (rank : 35)
Query Neighborhood Hits	409	Target Neighborhood Hits	236	Shared Neighborhood Hits	193
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G2_HUMAN
NC score	0.618395 (rank : 11)	θ value	8.11959e-09 (rank : 22)
Query Neighborhood Hits	409	Target Neighborhood Hits	324	Shared Neighborhood Hits	198
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
NC score	0.617825 (rank : 12)	θ value	2.36244e-08 (rank : 28)
Query Neighborhood Hits	409	Target Neighborhood Hits	222	Shared Neighborhood Hits	187
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

GRB2_HUMAN
NC score	0.609829 (rank : 13)	θ value	4.44505e-15 (rank : 11)
Query Neighborhood Hits	409	Target Neighborhood Hits	310	Shared Neighborhood Hits	196
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SH3G2_MOUSE
NC score	0.609712 (rank : 14)	θ value	5.26297e-08 (rank : 32)
Query Neighborhood Hits	409	Target Neighborhood Hits	319	Shared Neighborhood Hits	198
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

NCF4_MOUSE
NC score	0.609506 (rank : 15)	θ value	4.92598e-06 (rank : 47)
Query Neighborhood Hits	409	Target Neighborhood Hits	177	Shared Neighborhood Hits	149
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRB2_MOUSE
NC score	0.608351 (rank : 16)	θ value	4.44505e-15 (rank : 12)
Query Neighborhood Hits	409	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ABI2_MOUSE
NC score	0.606092 (rank : 17)	θ value	8.40245e-06 (rank : 52)
Query Neighborhood Hits	409	Target Neighborhood Hits	266	Shared Neighborhood Hits	191
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SH3G1_MOUSE
NC score	0.606067 (rank : 18)	θ value	1.06045e-08 (rank : 23)
Query Neighborhood Hits	409	Target Neighborhood Hits	291	Shared Neighborhood Hits	194
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ABI1_MOUSE
NC score	0.602848 (rank : 19)	θ value	1.53129e-07 (rank : 36)
Query Neighborhood Hits	409	Target Neighborhood Hits	246	Shared Neighborhood Hits	180
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
NC score	0.602090 (rank : 20)	θ value	8.40245e-06 (rank : 51)
Query Neighborhood Hits	409	Target Neighborhood Hits	350	Shared Neighborhood Hits	205
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SH3G1_HUMAN
NC score	0.599274 (rank : 21)	θ value	3.08544e-08 (rank : 29)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	195
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

NCF4_HUMAN
NC score	0.594566 (rank : 22)	θ value	1.29631e-06 (rank : 41)
Query Neighborhood Hits	409	Target Neighborhood Hits	161	Shared Neighborhood Hits	131
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DNMBP_HUMAN
NC score	0.589115 (rank : 23)	θ value	6.41864e-14 (rank : 13)
Query Neighborhood Hits	409	Target Neighborhood Hits	413	Shared Neighborhood Hits	211
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCK2_HUMAN
NC score	0.588404 (rank : 24)	θ value	1.47974e-10 (rank : 17)
Query Neighborhood Hits	409	Target Neighborhood Hits	310	Shared Neighborhood Hits	198
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.587694 (rank : 25)	θ value	4.76016e-09 (rank : 21)
Query Neighborhood Hits	409	Target Neighborhood Hits	312	Shared Neighborhood Hits	197
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

HCLS1_MOUSE
NC score	0.587034 (rank : 26)	θ value	9.29e-05 (rank : 76)
Query Neighborhood Hits	409	Target Neighborhood Hits	329	Shared Neighborhood Hits	196
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

DNMBP_MOUSE
NC score	0.586761 (rank : 27)	θ value	9.26847e-13 (rank : 16)
Query Neighborhood Hits	409	Target Neighborhood Hits	435	Shared Neighborhood Hits	221
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRC8_MOUSE
NC score	0.586199 (rank : 28)	θ value	2.21117e-06 (rank : 43)
Query Neighborhood Hits	409	Target Neighborhood Hits	292	Shared Neighborhood Hits	190
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.585735 (rank : 29)	θ value	0.000158464 (rank : 81)
Query Neighborhood Hits	409	Target Neighborhood Hits	269	Shared Neighborhood Hits	191
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

GRAP_MOUSE
NC score	0.582974 (rank : 30)	θ value	5.62301e-10 (rank : 18)
Query Neighborhood Hits	409	Target Neighborhood Hits	309	Shared Neighborhood Hits	206
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

HCLS1_HUMAN
NC score	0.582156 (rank : 31)	θ value	0.00020696 (rank : 84)
Query Neighborhood Hits	409	Target Neighborhood Hits	358	Shared Neighborhood Hits	191
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI1_HUMAN
NC score	0.581407 (rank : 32)	θ value	7.59969e-07 (rank : 39)
Query Neighborhood Hits	409	Target Neighborhood Hits	257	Shared Neighborhood Hits	182
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

GRAP_HUMAN
NC score	0.572874 (rank : 33)	θ value	3.64472e-09 (rank : 20)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	200
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PPIP1_HUMAN
NC score	0.564348 (rank : 34)	θ value	4.45536e-07 (rank : 38)
Query Neighborhood Hits	409	Target Neighborhood Hits	389	Shared Neighborhood Hits	202
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.556808 (rank : 35)	θ value	2.88788e-06 (rank : 45)
Query Neighborhood Hits	409	Target Neighborhood Hits	377	Shared Neighborhood Hits	205
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ARHG7_MOUSE
NC score	0.555575 (rank : 36)	θ value	1.38499e-08 (rank : 26)
Query Neighborhood Hits	409	Target Neighborhood Hits	396	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP2_MOUSE
NC score	0.553476 (rank : 37)	θ value	9.29e-05 (rank : 75)
Query Neighborhood Hits	409	Target Neighborhood Hits	297	Shared Neighborhood Hits	196
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ABI3_HUMAN
NC score	0.548751 (rank : 38)	θ value	5.44631e-05 (rank : 69)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	152
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAC_HUMAN
NC score	0.546548 (rank : 39)	θ value	9.92553e-07 (rank : 40)
Query Neighborhood Hits	409	Target Neighborhood Hits	276	Shared Neighborhood Hits	180
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI3_MOUSE
NC score	0.545375 (rank : 40)	θ value	4.1701e-05 (rank : 64)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	150
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

GRAP2_HUMAN
NC score	0.544312 (rank : 41)	θ value	0.000121331 (rank : 78)
Query Neighborhood Hits	409	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCF1_MOUSE
NC score	0.543590 (rank : 42)	θ value	5.44631e-05 (rank : 71)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	168
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

LASP1_MOUSE
NC score	0.541392 (rank : 43)	θ value	1.80886e-08 (rank : 27)
Query Neighborhood Hits	409	Target Neighborhood Hits	297	Shared Neighborhood Hits	168
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_HUMAN
NC score	0.541152 (rank : 44)	θ value	5.26297e-08 (rank : 31)
Query Neighborhood Hits	409	Target Neighborhood Hits	293	Shared Neighborhood Hits	168
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

STAM1_MOUSE
NC score	0.540239 (rank : 45)	θ value	1.87187e-05 (rank : 56)
Query Neighborhood Hits	409	Target Neighborhood Hits	273	Shared Neighborhood Hits	190
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.537618 (rank : 46)	θ value	4.1701e-05 (rank : 68)
Query Neighborhood Hits	409	Target Neighborhood Hits	271	Shared Neighborhood Hits	189
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG7_HUMAN
NC score	0.534912 (rank : 47)	θ value	2.88788e-06 (rank : 44)
Query Neighborhood Hits	409	Target Neighborhood Hits	347	Shared Neighborhood Hits	198
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NCF1_HUMAN
NC score	0.534633 (rank : 48)	θ value	0.000786445 (rank : 94)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	157
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

STAC_MOUSE
NC score	0.532882 (rank : 49)	θ value	8.40245e-06 (rank : 53)
Query Neighborhood Hits	409	Target Neighborhood Hits	268	Shared Neighborhood Hits	175
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG6_MOUSE
NC score	0.532221 (rank : 50)	θ value	3.41135e-07 (rank : 37)
Query Neighborhood Hits	409	Target Neighborhood Hits	394	Shared Neighborhood Hits	191
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CRKL_HUMAN
NC score	0.529569 (rank : 51)	θ value	9.29e-05 (rank : 74)
Query Neighborhood Hits	409	Target Neighborhood Hits	313	Shared Neighborhood Hits	191
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAM2_MOUSE
NC score	0.528023 (rank : 52)	θ value	9.29e-05 (rank : 77)
Query Neighborhood Hits	409	Target Neighborhood Hits	285	Shared Neighborhood Hits	192
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ARHG6_HUMAN
NC score	0.525823 (rank : 53)	θ value	2.21117e-06 (rank : 42)
Query Neighborhood Hits	409	Target Neighborhood Hits	376	Shared Neighborhood Hits	192
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CRKL_MOUSE
NC score	0.524006 (rank : 54)	θ value	0.00020696 (rank : 83)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	188
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
NC score	0.523118 (rank : 55)	θ value	3.19293e-05 (rank : 61)
Query Neighborhood Hits	409	Target Neighborhood Hits	314	Shared Neighborhood Hits	189
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAM2_HUMAN
NC score	0.520869 (rank : 56)	θ value	2.44474e-05 (rank : 59)
Query Neighborhood Hits	409	Target Neighborhood Hits	288	Shared Neighborhood Hits	191
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CRK_HUMAN
NC score	0.514910 (rank : 57)	θ value	5.44631e-05 (rank : 70)
Query Neighborhood Hits	409	Target Neighborhood Hits	308	Shared Neighborhood Hits	190
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NEBL_HUMAN
NC score	0.512886 (rank : 58)	θ value	2.79066e-09 (rank : 19)
Query Neighborhood Hits	409	Target Neighborhood Hits	457	Shared Neighborhood Hits	184
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

VAV_MOUSE
NC score	0.494452 (rank : 59)	θ value	6.43352e-06 (rank : 50)
Query Neighborhood Hits	409	Target Neighborhood Hits	430	Shared Neighborhood Hits	202
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.494040 (rank : 60)	θ value	4.92598e-06 (rank : 48)
Query Neighborhood Hits	409	Target Neighborhood Hits	452	Shared Neighborhood Hits	200
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_MOUSE
NC score	0.487273 (rank : 61)	θ value	1.06045e-08 (rank : 25)
Query Neighborhood Hits	409	Target Neighborhood Hits	456	Shared Neighborhood Hits	194
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.486176 (rank : 62)	θ value	1.06045e-08 (rank : 24)
Query Neighborhood Hits	409	Target Neighborhood Hits	453	Shared Neighborhood Hits	193
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PACN2_HUMAN
NC score	0.484684 (rank : 63)	θ value	0.00175202 (rank : 100)
Query Neighborhood Hits	409	Target Neighborhood Hits	339	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.480636 (rank : 64)	θ value	0.00390308 (rank : 108)
Query Neighborhood Hits	409	Target Neighborhood Hits	382	Shared Neighborhood Hits	196
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ITSN2_HUMAN
NC score	0.479034 (rank : 65)	θ value	8.95645e-16 (rank : 9)
Query Neighborhood Hits	409	Target Neighborhood Hits	1173	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

OSTF1_HUMAN
NC score	0.475352 (rank : 66)	θ value	2.44474e-05 (rank : 57)
Query Neighborhood Hits	409	Target Neighborhood Hits	466	Shared Neighborhood Hits	200
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PACN1_HUMAN
NC score	0.473000 (rank : 67)	θ value	0.0113563 (rank : 123)
Query Neighborhood Hits	409	Target Neighborhood Hits	320	Shared Neighborhood Hits	185
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.472340 (rank : 68)	θ value	0.0113563 (rank : 124)
Query Neighborhood Hits	409	Target Neighborhood Hits	283	Shared Neighborhood Hits	185
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

DBNL_HUMAN
NC score	0.466137 (rank : 69)	θ value	0.0330416 (rank : 138)
Query Neighborhood Hits	409	Target Neighborhood Hits	244	Shared Neighborhood Hits	158
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

VAV3_HUMAN
NC score	0.461689 (rank : 70)	θ value	4.0297e-08 (rank : 30)
Query Neighborhood Hits	409	Target Neighborhood Hits	398	Shared Neighborhood Hits	188
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

OSTF1_MOUSE
NC score	0.459002 (rank : 71)	θ value	0.000158464 (rank : 80)
Query Neighborhood Hits	409	Target Neighborhood Hits	467	Shared Neighborhood Hits	199
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DBNL_MOUSE
NC score	0.458696 (rank : 72)	θ value	0.0330416 (rank : 139)
Query Neighborhood Hits	409	Target Neighborhood Hits	306	Shared Neighborhood Hits	160
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ITSN2_MOUSE
NC score	0.458353 (rank : 73)	θ value	1.38178e-16 (rank : 5)
Query Neighborhood Hits	409	Target Neighborhood Hits	1371	Shared Neighborhood Hits	232
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV3_MOUSE
NC score	0.455537 (rank : 74)	θ value	8.97725e-08 (rank : 33)
Query Neighborhood Hits	409	Target Neighborhood Hits	404	Shared Neighborhood Hits	185
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ITSN1_MOUSE
NC score	0.453877 (rank : 75)	θ value	1.52774e-15 (rank : 10)
Query Neighborhood Hits	409	Target Neighborhood Hits	1669	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.453153 (rank : 76)	θ value	3.07829e-16 (rank : 6)
Query Neighborhood Hits	409	Target Neighborhood Hits	1757	Shared Neighborhood Hits	266
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PACN3_HUMAN
NC score	0.452052 (rank : 77)	θ value	0.0113563 (rank : 125)
Query Neighborhood Hits	409	Target Neighborhood Hits	385	Shared Neighborhood Hits	185
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
NC score	0.449011 (rank : 78)	θ value	0.0252991 (rank : 136)
Query Neighborhood Hits	409	Target Neighborhood Hits	380	Shared Neighborhood Hits	189
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NPHP1_MOUSE
NC score	0.442013 (rank : 79)	θ value	0.0193708 (rank : 131)
Query Neighborhood Hits	409	Target Neighborhood Hits	267	Shared Neighborhood Hits	171
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STAC3_MOUSE
NC score	0.433462 (rank : 80)	θ value	1.06291 (rank : 243)
Query Neighborhood Hits	409	Target Neighborhood Hits	232	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NEBU_HUMAN
NC score	0.433296 (rank : 81)	θ value	1.17247e-07 (rank : 34)
Query Neighborhood Hits	409	Target Neighborhood Hits	420	Shared Neighborhood Hits	182
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

STAC3_HUMAN
NC score	0.430596 (rank : 82)	θ value	1.06291 (rank : 242)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	146
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

EFS_MOUSE
NC score	0.399535 (rank : 83)	θ value	0.0563607 (rank : 145)
Query Neighborhood Hits	409	Target Neighborhood Hits	389	Shared Neighborhood Hits	178
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

NPHP1_HUMAN
NC score	0.396515 (rank : 84)	θ value	0.0961366 (rank : 162)
Query Neighborhood Hits	409	Target Neighborhood Hits	288	Shared Neighborhood Hits	160
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

CT032_HUMAN
NC score	0.394589 (rank : 85)	θ value	0.47712 (rank : 200)
Query Neighborhood Hits	409	Target Neighborhood Hits	235	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PLCG1_MOUSE
NC score	0.390937 (rank : 86)	θ value	0.00175202 (rank : 101)
Query Neighborhood Hits	409	Target Neighborhood Hits	314	Shared Neighborhood Hits	167
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

EFS_HUMAN
NC score	0.387778 (rank : 87)	θ value	0.0330416 (rank : 140)
Query Neighborhood Hits	409	Target Neighborhood Hits	348	Shared Neighborhood Hits	167
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

AHI1_MOUSE
NC score	0.386328 (rank : 88)	θ value	0.00175202 (rank : 98)
Query Neighborhood Hits	409	Target Neighborhood Hits	496	Shared Neighborhood Hits	200
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AHI1_HUMAN
NC score	0.383010 (rank : 89)	θ value	0.00869519 (rank : 114)
Query Neighborhood Hits	409	Target Neighborhood Hits	537	Shared Neighborhood Hits	202
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SNX18_MOUSE
NC score	0.378016 (rank : 90)	θ value	0.00869519 (rank : 122)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	134
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BCAR1_MOUSE
NC score	0.375925 (rank : 91)	θ value	0.0252991 (rank : 135)
Query Neighborhood Hits	409	Target Neighborhood Hits	438	Shared Neighborhood Hits	183
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PLCG1_HUMAN
NC score	0.372436 (rank : 92)	θ value	0.00869519 (rank : 120)
Query Neighborhood Hits	409	Target Neighborhood Hits	293	Shared Neighborhood Hits	159
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
NC score	0.371777 (rank : 93)	θ value	0.00869519 (rank : 121)
Query Neighborhood Hits	409	Target Neighborhood Hits	280	Shared Neighborhood Hits	157
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

BCAR1_HUMAN
NC score	0.368951 (rank : 94)	θ value	0.0252991 (rank : 134)
Query Neighborhood Hits	409	Target Neighborhood Hits	554	Shared Neighborhood Hits	187
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SNX18_HUMAN
NC score	0.368934 (rank : 95)	θ value	0.0431538 (rank : 143)
Query Neighborhood Hits	409	Target Neighborhood Hits	207	Shared Neighborhood Hits	139
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHG4_HUMAN
NC score	0.362691 (rank : 96)	θ value	0.125558 (rank : 165)
Query Neighborhood Hits	409	Target Neighborhood Hits	242	Shared Neighborhood Hits	159
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RHG04_HUMAN
NC score	0.362041 (rank : 97)	θ value	3.19293e-05 (rank : 62)
Query Neighborhood Hits	409	Target Neighborhood Hits	307	Shared Neighborhood Hits	168
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

STS2_HUMAN
NC score	0.356283 (rank : 98)	θ value	0.000158464 (rank : 82)
Query Neighborhood Hits	409	Target Neighborhood Hits	108	Shared Neighborhood Hits	95
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

CASL_MOUSE
NC score	0.344041 (rank : 99)	θ value	0.0961366 (rank : 158)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	149
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

SRGP2_MOUSE
NC score	0.343094 (rank : 100)	θ value	3.19293e-05 (rank : 63)
Query Neighborhood Hits	409	Target Neighborhood Hits	324	Shared Neighborhood Hits	162
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.341140 (rank : 101)	θ value	2.44474e-05 (rank : 58)
Query Neighborhood Hits	409	Target Neighborhood Hits	331	Shared Neighborhood Hits	162
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ARHG9_HUMAN
NC score	0.340671 (rank : 102)	θ value	1.81305 (rank : 257)
Query Neighborhood Hits	409	Target Neighborhood Hits	235	Shared Neighborhood Hits	153
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.340531 (rank : 103)	θ value	1.81305 (rank : 258)
Query Neighborhood Hits	409	Target Neighborhood Hits	234	Shared Neighborhood Hits	152
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CASL_HUMAN
NC score	0.339578 (rank : 104)	θ value	0.0961366 (rank : 157)
Query Neighborhood Hits	409	Target Neighborhood Hits	259	Shared Neighborhood Hits	151
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

RIMB2_MOUSE
NC score	0.331735 (rank : 105)	θ value	0.0736092 (rank : 153)
Query Neighborhood Hits	409	Target Neighborhood Hits	246	Shared Neighborhood Hits	114
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SHLB1_MOUSE
NC score	0.326698 (rank : 106)	θ value	0.0252991 (rank : 137)
Query Neighborhood Hits	409	Target Neighborhood Hits	101	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

FNBP2_HUMAN
NC score	0.325637 (rank : 107)	θ value	1.43324e-05 (rank : 54)
Query Neighborhood Hits	409	Target Neighborhood Hits	432	Shared Neighborhood Hits	166
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

PEX13_MOUSE
NC score	0.324242 (rank : 108)	θ value	5.27518 (rank : 345)
Query Neighborhood Hits	409	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SRGP1_HUMAN
NC score	0.323901 (rank : 109)	θ value	4.1701e-05 (rank : 67)
Query Neighborhood Hits	409	Target Neighborhood Hits	390	Shared Neighborhood Hits	152
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SHLB1_HUMAN
NC score	0.320050 (rank : 110)	θ value	0.0330416 (rank : 141)
Query Neighborhood Hits	409	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

RIMB2_HUMAN
NC score	0.319178 (rank : 111)	θ value	1.81305 (rank : 265)
Query Neighborhood Hits	409	Target Neighborhood Hits	263	Shared Neighborhood Hits	124
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

STS1_HUMAN
NC score	0.316788 (rank : 112)	θ value	1.43324e-05 (rank : 55)
Query Neighborhood Hits	409	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.315576 (rank : 113)	θ value	2.44474e-05 (rank : 60)
Query Neighborhood Hits	409	Target Neighborhood Hits	104	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

PEX13_HUMAN
NC score	0.314465 (rank : 114)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	409	Target Neighborhood Hits	128	Shared Neighborhood Hits	112
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ARHG5_HUMAN
NC score	0.300254 (rank : 115)	θ value	0.00869519 (rank : 115)
Query Neighborhood Hits	409	Target Neighborhood Hits	172	Shared Neighborhood Hits	102
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RUSC1_HUMAN
NC score	0.299287 (rank : 116)	θ value	0.813845 (rank : 225)
Query Neighborhood Hits	409	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SHLB2_MOUSE
NC score	0.296849 (rank : 117)	θ value	0.0148317 (rank : 128)
Query Neighborhood Hits	409	Target Neighborhood Hits	88	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.295152 (rank : 118)	θ value	0.0148317 (rank : 127)
Query Neighborhood Hits	409	Target Neighborhood Hits	86	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ARHG4_MOUSE
NC score	0.291955 (rank : 119)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	409	Target Neighborhood Hits	185	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NOXO1_MOUSE
NC score	0.290894 (rank : 120)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	409	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ES8L3_MOUSE
NC score	0.287683 (rank : 121)	θ value	0.62314 (rank : 211)
Query Neighborhood Hits	409	Target Neighborhood Hits	168	Shared Neighborhood Hits	140
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

RHG26_HUMAN
NC score	0.287535 (rank : 122)	θ value	0.125558 (rank : 169)
Query Neighborhood Hits	409	Target Neighborhood Hits	281	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

NGEF_MOUSE
NC score	0.287354 (rank : 123)	θ value	5.44631e-05 (rank : 72)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	102
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.284368 (rank : 124)	θ value	4.1701e-05 (rank : 66)
Query Neighborhood Hits	409	Target Neighborhood Hits	166	Shared Neighborhood Hits	87
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ANM2_HUMAN
NC score	0.274354 (rank : 125)	θ value	0.47712 (rank : 195)
Query Neighborhood Hits	409	Target Neighborhood Hits	175	Shared Neighborhood Hits	144
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RUSC1_MOUSE
NC score	0.273473 (rank : 126)	θ value	5.27518 (rank : 347)
Query Neighborhood Hits	409	Target Neighborhood Hits	206	Shared Neighborhood Hits	134
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ES8L3_HUMAN
NC score	0.272487 (rank : 127)	θ value	0.0961366 (rank : 159)
Query Neighborhood Hits	409	Target Neighborhood Hits	206	Shared Neighborhood Hits	124
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SNX9_HUMAN
NC score	0.271808 (rank : 128)	θ value	0.21417 (rank : 182)
Query Neighborhood Hits	409	Target Neighborhood Hits	148	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

IASPP_HUMAN
NC score	0.266665 (rank : 129)	θ value	1.06291 (rank : 236)
Query Neighborhood Hits	409	Target Neighborhood Hits	688	Shared Neighborhood Hits	181
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANM2_MOUSE
NC score	0.261785 (rank : 130)	θ value	1.06291 (rank : 228)
Query Neighborhood Hits	409	Target Neighborhood Hits	175	Shared Neighborhood Hits	143
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

DDEF1_MOUSE
NC score	0.260125 (rank : 131)	θ value	0.00869519 (rank : 116)
Query Neighborhood Hits	409	Target Neighborhood Hits	592	Shared Neighborhood Hits	161
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

P85A_MOUSE
NC score	0.258020 (rank : 132)	θ value	0.0193708 (rank : 132)
Query Neighborhood Hits	409	Target Neighborhood Hits	435	Shared Neighborhood Hits	132
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SPTA2_HUMAN
NC score	0.254696 (rank : 133)	θ value	2.88788e-06 (rank : 46)
Query Neighborhood Hits	409	Target Neighborhood Hits	888	Shared Neighborhood Hits	189
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DDEF2_MOUSE
NC score	0.248133 (rank : 134)	θ value	0.00665767 (rank : 113)
Query Neighborhood Hits	409	Target Neighborhood Hits	625	Shared Neighborhood Hits	182
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ASPP1_MOUSE
NC score	0.247325 (rank : 135)	θ value	0.21417 (rank : 177)
Query Neighborhood Hits	409	Target Neighborhood Hits	1244	Shared Neighborhood Hits	212
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SNX9_MOUSE
NC score	0.246991 (rank : 136)	θ value	0.279714 (rank : 190)
Query Neighborhood Hits	409	Target Neighborhood Hits	141	Shared Neighborhood Hits	94
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

IASPP_MOUSE
NC score	0.246628 (rank : 137)	θ value	0.62314 (rank : 213)
Query Neighborhood Hits	409	Target Neighborhood Hits	1024	Shared Neighborhood Hits	203
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MYO1F_HUMAN
NC score	0.246601 (rank : 138)	θ value	0.00035302 (rank : 85)
Query Neighborhood Hits	409	Target Neighborhood Hits	275	Shared Neighborhood Hits	186
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.245330 (rank : 139)	θ value	0.000461057 (rank : 90)
Query Neighborhood Hits	409	Target Neighborhood Hits	262	Shared Neighborhood Hits	185
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

P85A_HUMAN
NC score	0.243960 (rank : 140)	θ value	0.0563607 (rank : 146)
Query Neighborhood Hits	409	Target Neighborhood Hits	479	Shared Neighborhood Hits	126
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ASPP1_HUMAN
NC score	0.243613 (rank : 141)	θ value	0.62314 (rank : 206)
Query Neighborhood Hits	409	Target Neighborhood Hits	956	Shared Neighborhood Hits	193
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MYO1E_HUMAN
NC score	0.239740 (rank : 142)	θ value	7.1131e-05 (rank : 73)
Query Neighborhood Hits	409	Target Neighborhood Hits	293	Shared Neighborhood Hits	190
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

DDEF2_HUMAN
NC score	0.239304 (rank : 143)	θ value	0.21417 (rank : 178)
Query Neighborhood Hits	409	Target Neighborhood Hits	599	Shared Neighborhood Hits	177
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

JIP2_MOUSE
NC score	0.237662 (rank : 144)	θ value	0.000602161 (rank : 93)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	67
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SPTA1_MOUSE
NC score	0.237661 (rank : 145)	θ value	0.00298849 (rank : 106)
Query Neighborhood Hits	409	Target Neighborhood Hits	675	Shared Neighborhood Hits	171
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

JIP2_HUMAN
NC score	0.237216 (rank : 146)	θ value	0.000602161 (rank : 92)
Query Neighborhood Hits	409	Target Neighborhood Hits	288	Shared Neighborhood Hits	87
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

P85B_HUMAN
NC score	0.236431 (rank : 147)	θ value	0.00035302 (rank : 86)
Query Neighborhood Hits	409	Target Neighborhood Hits	543	Shared Neighborhood Hits	103
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ARHGG_MOUSE
NC score	0.236032 (rank : 148)	θ value	0.62314 (rank : 205)
Query Neighborhood Hits	409	Target Neighborhood Hits	152	Shared Neighborhood Hits	71
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SPTA1_HUMAN
NC score	0.232704 (rank : 149)	θ value	0.00298849 (rank : 105)
Query Neighborhood Hits	409	Target Neighborhood Hits	748	Shared Neighborhood Hits	177
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

P85B_MOUSE
NC score	0.228769 (rank : 150)	θ value	0.00175202 (rank : 99)
Query Neighborhood Hits	409	Target Neighborhood Hits	519	Shared Neighborhood Hits	100
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TCGAP_MOUSE
NC score	0.222305 (rank : 151)	θ value	2.36792 (rank : 285)
Query Neighborhood Hits	409	Target Neighborhood Hits	409	Shared Neighborhood Hits	143
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

EPS8_HUMAN
NC score	0.221892 (rank : 152)	θ value	0.125558 (rank : 166)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	107
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
NC score	0.217799 (rank : 153)	θ value	0.813845 (rank : 220)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	122
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

JIP1_MOUSE
NC score	0.216670 (rank : 154)	θ value	0.00509761 (rank : 111)
Query Neighborhood Hits	409	Target Neighborhood Hits	259	Shared Neighborhood Hits	84
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ARHGG_HUMAN
NC score	0.212476 (rank : 155)	θ value	0.47712 (rank : 196)
Query Neighborhood Hits	409	Target Neighborhood Hits	129	Shared Neighborhood Hits	54
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DOCK1_HUMAN
NC score	0.212398 (rank : 156)	θ value	0.0193708 (rank : 130)
Query Neighborhood Hits	409	Target Neighborhood Hits	191	Shared Neighborhood Hits	123
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ASPP2_HUMAN
NC score	0.212391 (rank : 157)	θ value	0.163984 (rank : 172)
Query Neighborhood Hits	409	Target Neighborhood Hits	1156	Shared Neighborhood Hits	189
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

JIP1_HUMAN
NC score	0.212137 (rank : 158)	θ value	0.00509761 (rank : 110)
Query Neighborhood Hits	409	Target Neighborhood Hits	271	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NOXO1_HUMAN
NC score	0.211307 (rank : 159)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	409	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

TCGAP_HUMAN
NC score	0.207679 (rank : 160)	θ value	2.36792 (rank : 284)
Query Neighborhood Hits	409	Target Neighborhood Hits	872	Shared Neighborhood Hits	176
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SHAN2_MOUSE
NC score	0.207351 (rank : 161)	θ value	4.03905 (rank : 323)
Query Neighborhood Hits	409	Target Neighborhood Hits	446	Shared Neighborhood Hits	120
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ES8L2_MOUSE
NC score	0.205016 (rank : 162)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	409	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_HUMAN
NC score	0.204794 (rank : 163)	θ value	8.99809 (rank : 393)
Query Neighborhood Hits	409	Target Neighborhood Hits	193	Shared Neighborhood Hits	129
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

AMPH_HUMAN
NC score	0.195697 (rank : 164)	θ value	2.36792 (rank : 270)
Query Neighborhood Hits	409	Target Neighborhood Hits	455	Shared Neighborhood Hits	117
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

RIMB1_HUMAN
NC score	0.193464 (rank : 165)	θ value	0.21417 (rank : 181)
Query Neighborhood Hits	409	Target Neighborhood Hits	1479	Shared Neighborhood Hits	182
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SLAP2_HUMAN
NC score	0.192703 (rank : 166)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	409	Target Neighborhood Hits	139	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

BIN1_MOUSE
NC score	0.192328 (rank : 167)	θ value	0.47712 (rank : 198)
Query Neighborhood Hits	409	Target Neighborhood Hits	283	Shared Neighborhood Hits	95
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BIN1_HUMAN
NC score	0.192223 (rank : 168)	θ value	0.47712 (rank : 197)
Query Neighborhood Hits	409	Target Neighborhood Hits	335	Shared Neighborhood Hits	95
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SLAP2_MOUSE
NC score	0.192139 (rank : 169)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	409	Target Neighborhood Hits	136	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ES8L1_MOUSE
NC score	0.191724 (rank : 170)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	409	Target Neighborhood Hits	143	Shared Neighborhood Hits	92
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SPN90_HUMAN
NC score	0.188694 (rank : 171)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

RIMB1_MOUSE
NC score	0.187535 (rank : 172)	θ value	0.0961366 (rank : 163)
Query Neighborhood Hits	409	Target Neighborhood Hits	1376	Shared Neighborhood Hits	188
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ES8L1_HUMAN
NC score	0.185152 (rank : 173)	θ value	5.27518 (rank : 337)
Query Neighborhood Hits	409	Target Neighborhood Hits	162	Shared Neighborhood Hits	108
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SLY_MOUSE
NC score	0.182512 (rank : 174)	θ value	3.0926 (rank : 296)
Query Neighborhood Hits	409	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

AMPH_MOUSE
NC score	0.180310 (rank : 175)	θ value	5.27518 (rank : 329)
Query Neighborhood Hits	409	Target Neighborhood Hits	291	Shared Neighborhood Hits	92
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

FYN_MOUSE
NC score	0.179139 (rank : 176)	θ value	0.00869519 (rank : 118)
Query Neighborhood Hits	409	Target Neighborhood Hits	1073	Shared Neighborhood Hits	198
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FGR_HUMAN
NC score	0.177461 (rank : 177)	θ value	0.0148317 (rank : 126)
Query Neighborhood Hits	409	Target Neighborhood Hits	1067	Shared Neighborhood Hits	193
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BAIP2_MOUSE
NC score	0.177060 (rank : 178)	θ value	0.0961366 (rank : 156)
Query Neighborhood Hits	409	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

FYN_HUMAN
NC score	0.176160 (rank : 179)	θ value	0.00869519 (rank : 117)
Query Neighborhood Hits	409	Target Neighborhood Hits	1078	Shared Neighborhood Hits	198
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

YES_MOUSE
NC score	0.176144 (rank : 180)	θ value	0.00102713 (rank : 97)
Query Neighborhood Hits	409	Target Neighborhood Hits	1052	Shared Neighborhood Hits	193
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BAIP2_HUMAN
NC score	0.176036 (rank : 181)	θ value	0.0961366 (rank : 155)
Query Neighborhood Hits	409	Target Neighborhood Hits	192	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

M3KL4_HUMAN
NC score	0.175006 (rank : 182)	θ value	4.1701e-05 (rank : 65)
Query Neighborhood Hits	409	Target Neighborhood Hits	1087	Shared Neighborhood Hits	192
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

YES_HUMAN
NC score	0.174475 (rank : 183)	θ value	0.00102713 (rank : 96)
Query Neighborhood Hits	409	Target Neighborhood Hits	1059	Shared Neighborhood Hits	193
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SRC_HUMAN
NC score	0.174162 (rank : 184)	θ value	0.00390308 (rank : 109)
Query Neighborhood Hits	409	Target Neighborhood Hits	1058	Shared Neighborhood Hits	195
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

PKHG1_HUMAN
NC score	0.171122 (rank : 185)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	409	Target Neighborhood Hits	174	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

SLAP1_HUMAN
NC score	0.170900 (rank : 186)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	409	Target Neighborhood Hits	113	Shared Neighborhood Hits	53
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.169428 (rank : 187)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	409	Target Neighborhood Hits	117	Shared Neighborhood Hits	54
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

FGR_MOUSE
NC score	0.169147 (rank : 188)	θ value	0.0736092 (rank : 151)
Query Neighborhood Hits	409	Target Neighborhood Hits	1069	Shared Neighborhood Hits	193
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SHAN1_HUMAN
NC score	0.168536 (rank : 189)	θ value	1.38821 (rank : 251)
Query Neighborhood Hits	409	Target Neighborhood Hits	1041	Shared Neighborhood Hits	179
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ARHG3_HUMAN
NC score	0.167036 (rank : 190)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	409	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

SPN90_MOUSE
NC score	0.167004 (rank : 191)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ARHG3_MOUSE
NC score	0.166799 (rank : 192)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	409	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

BI2L1_HUMAN
NC score	0.164407 (rank : 193)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	409	Target Neighborhood Hits	156	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ARHG8_MOUSE
NC score	0.164183 (rank : 194)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	409	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

RASA1_HUMAN
NC score	0.163728 (rank : 195)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	409	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

P55G_HUMAN
NC score	0.163305 (rank : 196)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	409	Target Neighborhood Hits	451	Shared Neighborhood Hits	70
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SLY_HUMAN
NC score	0.162283 (rank : 197)	θ value	1.38821 (rank : 252)
Query Neighborhood Hits	409	Target Neighborhood Hits	81	Shared Neighborhood Hits	55
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

P55G_MOUSE
NC score	0.162005 (rank : 198)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	409	Target Neighborhood Hits	401	Shared Neighborhood Hits	67
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

M3K11_HUMAN
NC score	0.161853 (rank : 199)	θ value	0.000461057 (rank : 89)
Query Neighborhood Hits	409	Target Neighborhood Hits	1136	Shared Neighborhood Hits	204
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TIAM1_MOUSE
NC score	0.159252 (rank : 200)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	33
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CIP4_HUMAN
NC score	0.158654 (rank : 201)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	409	Target Neighborhood Hits	374	Shared Neighborhood Hits	83
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

PREX1_HUMAN
NC score	0.158428 (rank : 202)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	409	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

BI2L1_MOUSE
NC score	0.157982 (rank : 203)	θ value	2.36792 (rank : 273)
Query Neighborhood Hits	409	Target Neighborhood Hits	197	Shared Neighborhood Hits	69
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

M3K9_HUMAN
NC score	0.157353 (rank : 204)	θ value	0.000158464 (rank : 79)
Query Neighborhood Hits	409	Target Neighborhood Hits	1123	Shared Neighborhood Hits	197
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

TIAM1_HUMAN
NC score	0.156762 (rank : 205)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG8_HUMAN
NC score	0.155229 (rank : 206)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	409	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

BTK_HUMAN
NC score	0.154548 (rank : 207)	θ value	0.0193708 (rank : 129)
Query Neighborhood Hits	409	Target Neighborhood Hits	1026	Shared Neighborhood Hits	190
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FUT8_HUMAN
NC score	0.153808 (rank : 208)	θ value	0.0961366 (rank : 160)
Query Neighborhood Hits	409	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

MCF2L_MOUSE
NC score	0.151312 (rank : 209)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	409	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

SRC_MOUSE
NC score	0.150369 (rank : 210)	θ value	0.47712 (rank : 204)
Query Neighborhood Hits	409	Target Neighborhood Hits	1033	Shared Neighborhood Hits	174
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_MOUSE
NC score	0.149453 (rank : 211)	θ value	0.21417 (rank : 179)
Query Neighborhood Hits	409	Target Neighborhood Hits	1029	Shared Neighborhood Hits	184
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

BTK_MOUSE
NC score	0.148794 (rank : 212)	θ value	0.0736092 (rank : 150)
Query Neighborhood Hits	409	Target Neighborhood Hits	1017	Shared Neighborhood Hits	180
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

HCK_HUMAN
NC score	0.148110 (rank : 213)	θ value	0.125558 (rank : 167)
Query Neighborhood Hits	409	Target Neighborhood Hits	1035	Shared Neighborhood Hits	183
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FUT8_MOUSE
NC score	0.147648 (rank : 214)	θ value	0.279714 (rank : 184)
Query Neighborhood Hits	409	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

DAPP1_MOUSE
NC score	0.146123 (rank : 215)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.143755 (rank : 216)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

M3K10_HUMAN
NC score	0.142875 (rank : 217)	θ value	0.00228821 (rank : 103)
Query Neighborhood Hits	409	Target Neighborhood Hits	1071	Shared Neighborhood Hits	173
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ARHGF_HUMAN
NC score	0.140241 (rank : 218)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	409	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FRK_HUMAN
NC score	0.139448 (rank : 219)	θ value	0.365318 (rank : 194)
Query Neighborhood Hits	409	Target Neighborhood Hits	1058	Shared Neighborhood Hits	187
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LYN_HUMAN
NC score	0.138210 (rank : 220)	θ value	0.62314 (rank : 215)
Query Neighborhood Hits	409	Target Neighborhood Hits	1022	Shared Neighborhood Hits	170
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.137861 (rank : 221)	θ value	0.279714 (rank : 187)
Query Neighborhood Hits	409	Target Neighborhood Hits	1023	Shared Neighborhood Hits	170
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CSK_MOUSE
NC score	0.136597 (rank : 222)	θ value	0.000461057 (rank : 88)
Query Neighborhood Hits	409	Target Neighborhood Hits	1009	Shared Neighborhood Hits	149
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.136401 (rank : 223)	θ value	0.000461057 (rank : 87)
Query Neighborhood Hits	409	Target Neighborhood Hits	1009	Shared Neighborhood Hits	149
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ECT2_MOUSE
NC score	0.136285 (rank : 224)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	409	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_MOUSE
NC score	0.134131 (rank : 225)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	409	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

RUSC2_HUMAN
NC score	0.133215 (rank : 226)	θ value	0.62314 (rank : 218)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

BLK_HUMAN
NC score	0.133074 (rank : 227)	θ value	0.279714 (rank : 183)
Query Neighborhood Hits	409	Target Neighborhood Hits	994	Shared Neighborhood Hits	155
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ARHGA_HUMAN
NC score	0.131894 (rank : 228)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	409	Target Neighborhood Hits	187	Shared Neighborhood Hits	25
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_HUMAN
NC score	0.131825 (rank : 229)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	409	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG1_HUMAN
NC score	0.131431 (rank : 230)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	409	Target Neighborhood Hits	176	Shared Neighborhood Hits	31
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

BLK_MOUSE
NC score	0.130621 (rank : 231)	θ value	0.365318 (rank : 193)
Query Neighborhood Hits	409	Target Neighborhood Hits	992	Shared Neighborhood Hits	144
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SHE_MOUSE
NC score	0.128989 (rank : 232)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	409	Target Neighborhood Hits	169	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

TXK_MOUSE
NC score	0.128835 (rank : 233)	θ value	0.0431538 (rank : 144)
Query Neighborhood Hits	409	Target Neighborhood Hits	980	Shared Neighborhood Hits	156
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

EM55_HUMAN
NC score	0.128419 (rank : 234)	θ value	1.06291 (rank : 231)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	96
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SH21B_MOUSE
NC score	0.127956 (rank : 235)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	409	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_HUMAN
NC score	0.126127 (rank : 236)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	409	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

MCF2_HUMAN
NC score	0.125379 (rank : 237)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	409	Target Neighborhood Hits	166	Shared Neighborhood Hits	28
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

EM55_MOUSE
NC score	0.123815 (rank : 238)	θ value	1.81305 (rank : 260)
Query Neighborhood Hits	409	Target Neighborhood Hits	221	Shared Neighborhood Hits	93
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SHE_HUMAN
NC score	0.123796 (rank : 239)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	409	Target Neighborhood Hits	164	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHC3_MOUSE
NC score	0.122563 (rank : 240)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

ARHG1_MOUSE
NC score	0.122468 (rank : 241)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	409	Target Neighborhood Hits	266	Shared Neighborhood Hits	31
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
NC score	0.121605 (rank : 242)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	409	Target Neighborhood Hits	375	Shared Neighborhood Hits	38
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

LCK_HUMAN
NC score	0.121405 (rank : 243)	θ value	0.813845 (rank : 222)
Query Neighborhood Hits	409	Target Neighborhood Hits	987	Shared Neighborhood Hits	133
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

ARHGC_MOUSE
NC score	0.120838 (rank : 244)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	409	Target Neighborhood Hits	344	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

APS_HUMAN
NC score	0.120824 (rank : 245)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	409	Target Neighborhood Hits	162	Shared Neighborhood Hits	49
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHGC_HUMAN
NC score	0.120757 (rank : 246)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	409	Target Neighborhood Hits	351	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LCK_MOUSE
NC score	0.120412 (rank : 247)	θ value	0.62314 (rank : 214)
Query Neighborhood Hits	409	Target Neighborhood Hits	981	Shared Neighborhood Hits	132
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BCR_HUMAN
NC score	0.120179 (rank : 248)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SHB_MOUSE
NC score	0.119302 (rank : 249)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	409	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

TXK_HUMAN
NC score	0.119075 (rank : 250)	θ value	1.81305 (rank : 268)
Query Neighborhood Hits	409	Target Neighborhood Hits	971	Shared Neighborhood Hits	141
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TEC_HUMAN
NC score	0.119038 (rank : 251)	θ value	8.99809 (rank : 407)
Query Neighborhood Hits	409	Target Neighborhood Hits	1006	Shared Neighborhood Hits	153
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PTK6_MOUSE
NC score	0.118975 (rank : 252)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	409	Target Neighborhood Hits	1026	Shared Neighborhood Hits	163
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SHC1_MOUSE
NC score	0.118312 (rank : 253)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	409	Target Neighborhood Hits	180	Shared Neighborhood Hits	63
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

PTK6_HUMAN
NC score	0.116853 (rank : 254)	θ value	4.03905 (rank : 321)
Query Neighborhood Hits	409	Target Neighborhood Hits	1020	Shared Neighborhood Hits	165
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SHD_MOUSE
NC score	0.116479 (rank : 255)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	409	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ABL1_HUMAN
NC score	0.115826 (rank : 256)	θ value	4.03905 (rank : 305)
Query Neighborhood Hits	409	Target Neighborhood Hits	1220	Shared Neighborhood Hits	164
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SHD_HUMAN
NC score	0.115772 (rank : 257)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	61
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHB_HUMAN
NC score	0.115375 (rank : 258)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	409	Target Neighborhood Hits	141	Shared Neighborhood Hits	55
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

TEC_MOUSE
NC score	0.115365 (rank : 259)	θ value	5.27518 (rank : 350)
Query Neighborhood Hits	409	Target Neighborhood Hits	1006	Shared Neighborhood Hits	152
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SHC1_HUMAN
NC score	0.115024 (rank : 260)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	409	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ABL1_MOUSE
NC score	0.114432 (rank : 261)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	409	Target Neighborhood Hits	1178	Shared Neighborhood Hits	156
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

GRB14_MOUSE
NC score	0.113558 (rank : 262)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	409	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

RHG09_HUMAN
NC score	0.113390 (rank : 263)	θ value	0.0563607 (rank : 147)
Query Neighborhood Hits	409	Target Neighborhood Hits	186	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

GNRP_MOUSE
NC score	0.113130 (rank : 264)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	409	Target Neighborhood Hits	191	Shared Neighborhood Hits	28
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SHC3_HUMAN
NC score	0.113029 (rank : 265)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	409	Target Neighborhood Hits	155	Shared Neighborhood Hits	51
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SASH1_HUMAN
NC score	0.111765 (rank : 266)	θ value	5.27518 (rank : 348)
Query Neighborhood Hits	409	Target Neighborhood Hits	292	Shared Neighborhood Hits	73
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SHC2_MOUSE
NC score	0.111704 (rank : 267)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.111295 (rank : 268)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	409	Target Neighborhood Hits	170	Shared Neighborhood Hits	59
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

GRB14_HUMAN
NC score	0.111158 (rank : 269)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	409	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

RGNEF_MOUSE
NC score	0.110378 (rank : 270)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	409	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

CHIN_MOUSE
NC score	0.110232 (rank : 271)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	409	Target Neighborhood Hits	229	Shared Neighborhood Hits	61
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ABL2_HUMAN
NC score	0.110022 (rank : 272)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	409	Target Neighborhood Hits	1045	Shared Neighborhood Hits	137
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

FGD3_MOUSE
NC score	0.109490 (rank : 273)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	409	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

LNK_MOUSE
NC score	0.109283 (rank : 274)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	409	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_HUMAN
NC score	0.108933 (rank : 275)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ARHG2_HUMAN
NC score	0.108711 (rank : 276)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	409	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

SASH1_MOUSE
NC score	0.108195 (rank : 277)	θ value	5.27518 (rank : 349)
Query Neighborhood Hits	409	Target Neighborhood Hits	263	Shared Neighborhood Hits	76
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CHIN_HUMAN
NC score	0.108144 (rank : 278)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

LBC_HUMAN
NC score	0.108031 (rank : 279)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	409	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MPP6_HUMAN
NC score	0.107841 (rank : 280)	θ value	6.88961 (rank : 373)
Query Neighborhood Hits	409	Target Neighborhood Hits	180	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

GNRP_HUMAN
NC score	0.107436 (rank : 281)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	409	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CHIO_HUMAN
NC score	0.107304 (rank : 282)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	409	Target Neighborhood Hits	220	Shared Neighborhood Hits	56
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

ABR_HUMAN
NC score	0.106882 (rank : 283)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	409	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RUSC2_MOUSE
NC score	0.106580 (rank : 284)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	409	Target Neighborhood Hits	305	Shared Neighborhood Hits	84
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ITK_HUMAN
NC score	0.105945 (rank : 285)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	409	Target Neighborhood Hits	1016	Shared Neighborhood Hits	147
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

FGD4_MOUSE
NC score	0.105720 (rank : 286)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.105280 (rank : 287)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	409	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHG2_MOUSE
NC score	0.103614 (rank : 288)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	409	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

FGD3_HUMAN
NC score	0.103422 (rank : 289)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	409	Target Neighborhood Hits	249	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

GRB7_MOUSE
NC score	0.103142 (rank : 290)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	409	Target Neighborhood Hits	157	Shared Neighborhood Hits	58
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

MPP6_MOUSE
NC score	0.102831 (rank : 291)	θ value	6.88961 (rank : 374)
Query Neighborhood Hits	409	Target Neighborhood Hits	187	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

HAPIP_HUMAN
NC score	0.101432 (rank : 292)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	409	Target Neighborhood Hits	350	Shared Neighborhood Hits	37
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
NC score	0.101265 (rank : 293)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	409	Target Neighborhood Hits	159	Shared Neighborhood Hits	46
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

RHG12_MOUSE
NC score	0.100456 (rank : 294)	θ value	3.0926 (rank : 294)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

FGD2_HUMAN
NC score	0.100271 (rank : 295)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	409	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

SRMS_MOUSE
NC score	0.097889 (rank : 296)	θ value	1.38821 (rank : 253)
Query Neighborhood Hits	409	Target Neighborhood Hits	964	Shared Neighborhood Hits	117
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ITK_MOUSE
NC score	0.097730 (rank : 297)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	409	Target Neighborhood Hits	985	Shared Neighborhood Hits	133
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

DOCK2_HUMAN
NC score	0.097165 (rank : 298)	θ value	5.27518 (rank : 336)
Query Neighborhood Hits	409	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
NC score	0.095312 (rank : 299)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	409	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

SAMN1_HUMAN
NC score	0.094992 (rank : 300)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	409	Target Neighborhood Hits	74	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

FGD2_MOUSE
NC score	0.094798 (rank : 301)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	409	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

MATK_MOUSE
NC score	0.093214 (rank : 302)	θ value	1.06291 (rank : 238)
Query Neighborhood Hits	409	Target Neighborhood Hits	952	Shared Neighborhood Hits	96
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

APS_MOUSE
NC score	0.092406 (rank : 303)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	409	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH21A_MOUSE
NC score	0.091800 (rank : 304)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	409	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

FGD1_HUMAN
NC score	0.091521 (rank : 305)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	409	Target Neighborhood Hits	367	Shared Neighborhood Hits	45
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RHG12_HUMAN
NC score	0.091300 (rank : 306)	θ value	6.88961 (rank : 381)
Query Neighborhood Hits	409	Target Neighborhood Hits	190	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SH21A_HUMAN
NC score	0.091172 (rank : 307)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	409	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

MDC1_HUMAN
NC score	0.091011 (rank : 308)	θ value	0.00509761 (rank : 112)
Query Neighborhood Hits	409	Target Neighborhood Hits	1446	Shared Neighborhood Hits	125
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SRMS_HUMAN
NC score	0.090863 (rank : 309)	θ value	2.36792 (rank : 282)
Query Neighborhood Hits	409	Target Neighborhood Hits	946	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

3BP1_HUMAN
NC score	0.090617 (rank : 310)	θ value	2.36792 (rank : 269)
Query Neighborhood Hits	409	Target Neighborhood Hits	376	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GRB7_HUMAN
NC score	0.090307 (rank : 311)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	409	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SAMN1_MOUSE
NC score	0.089481 (rank : 312)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	409	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

FGD1_MOUSE
NC score	0.089298 (rank : 313)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	409	Target Neighborhood Hits	387	Shared Neighborhood Hits	46
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD6_MOUSE
NC score	0.088824 (rank : 314)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	409	Target Neighborhood Hits	282	Shared Neighborhood Hits	44
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SH22A_MOUSE
NC score	0.088716 (rank : 315)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	409	Target Neighborhood Hits	179	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH2D3_MOUSE
NC score	0.088715 (rank : 316)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	409	Target Neighborhood Hits	174	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH24A_HUMAN
NC score	0.087691 (rank : 317)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	409	Target Neighborhood Hits	455	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

LCP2_HUMAN
NC score	0.087664 (rank : 318)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	409	Target Neighborhood Hits	531	Shared Neighborhood Hits	92
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
NC score	0.086709 (rank : 319)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	409	Target Neighborhood Hits	177	Shared Neighborhood Hits	53
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MATK_HUMAN
NC score	0.086495 (rank : 320)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	409	Target Neighborhood Hits	954	Shared Neighborhood Hits	92
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

GRB10_MOUSE
NC score	0.085596 (rank : 321)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	409	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

MPP5_HUMAN
NC score	0.085452 (rank : 322)	θ value	5.27518 (rank : 342)
Query Neighborhood Hits	409	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

PPIP2_HUMAN
NC score	0.084810 (rank : 323)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	409	Target Neighborhood Hits	254	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

MPP5_MOUSE
NC score	0.084692 (rank : 324)	θ value	5.27518 (rank : 343)
Query Neighborhood Hits	409	Target Neighborhood Hits	226	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

BCAR3_HUMAN
NC score	0.084616 (rank : 325)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	409	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

PTN11_MOUSE
NC score	0.084338 (rank : 326)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.084326 (rank : 327)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

BCAR3_MOUSE
NC score	0.084174 (rank : 328)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	409	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

GRB10_HUMAN
NC score	0.084008 (rank : 329)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	409	Target Neighborhood Hits	147	Shared Neighborhood Hits	49
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

FARP2_MOUSE
NC score	0.083966 (rank : 330)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	409	Target Neighborhood Hits	209	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

BLNK_MOUSE
NC score	0.082827 (rank : 331)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	409	Target Neighborhood Hits	296	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SH2D3_HUMAN
NC score	0.082643 (rank : 332)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	409	Target Neighborhood Hits	188	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

DOCK4_MOUSE
NC score	0.082141 (rank : 333)	θ value	0.47712 (rank : 202)
Query Neighborhood Hits	409	Target Neighborhood Hits	210	Shared Neighborhood Hits	39
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_HUMAN
NC score	0.081801 (rank : 334)	θ value	0.47712 (rank : 201)
Query Neighborhood Hits	409	Target Neighborhood Hits	237	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK3_MOUSE
NC score	0.081648 (rank : 335)	θ value	0.163984 (rank : 175)
Query Neighborhood Hits	409	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

PPIP2_MOUSE
NC score	0.079978 (rank : 336)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	409	Target Neighborhood Hits	308	Shared Neighborhood Hits	30
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

CBP_MOUSE
NC score	0.078885 (rank : 337)	θ value	0.000602161 (rank : 91)
Query Neighborhood Hits	409	Target Neighborhood Hits	1051	Shared Neighborhood Hits	92
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SOCS7_MOUSE
NC score	0.078714 (rank : 338)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	409	Target Neighborhood Hits	154	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

DOCK3_HUMAN
NC score	0.078488 (rank : 339)	θ value	0.163984 (rank : 174)
Query Neighborhood Hits	409	Target Neighborhood Hits	87	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

SOCS2_MOUSE
NC score	0.078252 (rank : 340)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

CBP_HUMAN
NC score	0.078161 (rank : 341)	θ value	0.00102713 (rank : 95)
Query Neighborhood Hits	409	Target Neighborhood Hits	941	Shared Neighborhood Hits	82
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

FGD6_HUMAN
NC score	0.077846 (rank : 342)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	409	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

RBBP6_MOUSE
NC score	0.077010 (rank : 343)	θ value	0.00175202 (rank : 102)
Query Neighborhood Hits	409	Target Neighborhood Hits	1014	Shared Neighborhood Hits	69
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SH23A_HUMAN
NC score	0.076661 (rank : 344)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	409	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH22A_HUMAN
NC score	0.076230 (rank : 345)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

FER_HUMAN
NC score	0.075181 (rank : 346)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	409	Target Neighborhood Hits	1278	Shared Neighborhood Hits	98
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

BLNK_HUMAN
NC score	0.074438 (rank : 347)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	409	Target Neighborhood Hits	228	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

HSH2D_MOUSE
NC score	0.074431 (rank : 348)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	409	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SOCS2_HUMAN
NC score	0.074189 (rank : 349)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	409	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

PCLO_HUMAN
NC score	0.074047 (rank : 350)	θ value	1.06291 (rank : 240)
Query Neighborhood Hits	409	Target Neighborhood Hits	2046	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

FARP2_HUMAN
NC score	0.073783 (rank : 351)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	409	Target Neighborhood Hits	240	Shared Neighborhood Hits	32
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PTN6_MOUSE
NC score	0.073419 (rank : 352)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SOCS6_MOUSE
NC score	0.073191 (rank : 353)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	409	Target Neighborhood Hits	146	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SH24A_MOUSE
NC score	0.072829 (rank : 354)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	409	Target Neighborhood Hits	326	Shared Neighborhood Hits	59
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

REPS2_HUMAN
NC score	0.072388 (rank : 355)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	409	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SOCS6_HUMAN
NC score	0.072231 (rank : 356)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	409	Target Neighborhood Hits	126	Shared Neighborhood Hits	40
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

FARP1_HUMAN
NC score	0.072133 (rank : 357)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	409	Target Neighborhood Hits	241	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TRIO_HUMAN
NC score	0.071950 (rank : 358)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	409	Target Neighborhood Hits	1580	Shared Neighborhood Hits	130
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PTN6_HUMAN
NC score	0.071880 (rank : 359)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	409	Target Neighborhood Hits	234	Shared Neighborhood Hits	58
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PKHG4_HUMAN
NC score	0.071433 (rank : 360)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	409	Target Neighborhood Hits	200	Shared Neighborhood Hits	21
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

CHIO_MOUSE
NC score	0.070729 (rank : 361)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	409	Target Neighborhood Hits	130	Shared Neighborhood Hits	27
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

MPP2_MOUSE
NC score	0.070640 (rank : 362)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	409	Target Neighborhood Hits	189	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

NRAP_MOUSE
NC score	0.070121 (rank : 363)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	409	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

MPP2_HUMAN
NC score	0.070052 (rank : 364)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	409	Target Neighborhood Hits	173	Shared Neighborhood Hits	70
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

REPS2_MOUSE
NC score	0.069736 (rank : 365)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	409	Target Neighborhood Hits	102	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG25_MOUSE
NC score	0.069605 (rank : 366)	θ value	0.279714 (rank : 189)
Query Neighborhood Hits	409	Target Neighborhood Hits	492	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SRRM2_HUMAN
NC score	0.069547 (rank : 367)	θ value	0.813845 (rank : 226)
Query Neighborhood Hits	409	Target Neighborhood Hits	1296	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

S3TC2_HUMAN
NC score	0.069490 (rank : 368)	θ value	1.38821 (rank : 250)
Query Neighborhood Hits	409	Target Neighborhood Hits	70	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

NRAP_HUMAN
NC score	0.069382 (rank : 369)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	409	Target Neighborhood Hits	159	Shared Neighborhood Hits	8
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

KSYK_MOUSE
NC score	0.068141 (rank : 370)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	409	Target Neighborhood Hits	944	Shared Neighborhood Hits	78
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ZAP70_MOUSE
NC score	0.067997 (rank : 371)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	409	Target Neighborhood Hits	905	Shared Neighborhood Hits	72
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

BMX_MOUSE
NC score	0.067531 (rank : 372)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	409	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.067417 (rank : 373)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	409	Target Neighborhood Hits	942	Shared Neighborhood Hits	68
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ZAP70_HUMAN
NC score	0.067001 (rank : 374)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	409	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CISH_HUMAN
NC score	0.066742 (rank : 375)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

KSYK_HUMAN
NC score	0.066703 (rank : 376)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	409	Target Neighborhood Hits	901	Shared Neighborhood Hits	72
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CISH_MOUSE
NC score	0.066668 (rank : 377)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

RBBP6_HUMAN
NC score	0.065616 (rank : 378)	θ value	0.0193708 (rank : 133)
Query Neighborhood Hits	409	Target Neighborhood Hits	1135	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

ACK1_MOUSE
NC score	0.064916 (rank : 379)	θ value	6.88961 (rank : 358)
Query Neighborhood Hits	409	Target Neighborhood Hits	1080	Shared Neighborhood Hits	110
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

TENS4_HUMAN
NC score	0.064294 (rank : 380)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	409	Target Neighborhood Hits	214	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

SRRM2_MOUSE
NC score	0.063896 (rank : 381)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	409	Target Neighborhood Hits	1470	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ACK1_HUMAN
NC score	0.063814 (rank : 382)	θ value	6.88961 (rank : 357)
Query Neighborhood Hits	409	Target Neighborhood Hits	1140	Shared Neighborhood Hits	107
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

AF9_HUMAN
NC score	0.062981 (rank : 383)	θ value	0.0736092 (rank : 148)
Query Neighborhood Hits	409	Target Neighborhood Hits	202	Shared Neighborhood Hits	23
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

MKL1_MOUSE
NC score	0.062766 (rank : 384)	θ value	0.00298849 (rank : 104)
Query Neighborhood Hits	409	Target Neighborhood Hits	667	Shared Neighborhood Hits	71
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

MPP4_MOUSE
NC score	0.062724 (rank : 385)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	409	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

3BP1_MOUSE
NC score	0.062571 (rank : 386)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	409	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TCOF_HUMAN
NC score	0.062315 (rank : 387)	θ value	0.125558 (rank : 170)
Query Neighborhood Hits	409	Target Neighborhood Hits	543	Shared Neighborhood Hits	51
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

REPS1_HUMAN
NC score	0.062210 (rank : 388)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	29
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

PCLO_MOUSE
NC score	0.061929 (rank : 389)	θ value	0.813845 (rank : 224)
Query Neighborhood Hits	409	Target Neighborhood Hits	2275	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

AFF4_MOUSE
NC score	0.061702 (rank : 390)	θ value	0.125558 (rank : 164)
Query Neighborhood Hits	409	Target Neighborhood Hits	581	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

OPHN1_HUMAN
NC score	0.061654 (rank : 391)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	409	Target Neighborhood Hits	161	Shared Neighborhood Hits	31
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

TENS4_MOUSE
NC score	0.061144 (rank : 392)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

RHG25_HUMAN
NC score	0.061079 (rank : 393)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	409	Target Neighborhood Hits	550	Shared Neighborhood Hits	43
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

NACAM_MOUSE
NC score	0.060709 (rank : 394)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	409	Target Neighborhood Hits	1866	Shared Neighborhood Hits	154
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

GMIP_MOUSE
NC score	0.060297 (rank : 395)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	409	Target Neighborhood Hits	202	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

TEX14_MOUSE
NC score	0.060028 (rank : 396)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	409	Target Neighborhood Hits	1333	Shared Neighborhood Hits	89
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

REPS1_MOUSE
NC score	0.059367 (rank : 397)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	409	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

TEX14_HUMAN
NC score	0.059080 (rank : 398)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	409	Target Neighborhood Hits	1103	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

OPHN1_MOUSE
NC score	0.058253 (rank : 399)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	409	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

NRIP1_MOUSE
NC score	0.057960 (rank : 400)	θ value	0.00390308 (rank : 107)
Query Neighborhood Hits	409	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CBD1, Q8C3Y8, Q9Z2K2	Gene names	Nrip1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

IWS1_HUMAN
NC score	0.057873 (rank : 401)	θ value	0.279714 (rank : 185)
Query Neighborhood Hits	409	Target Neighborhood Hits	1241	Shared Neighborhood Hits	96
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

DUET_HUMAN
NC score	0.057786 (rank : 402)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	409	Target Neighborhood Hits	1220	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

SOS1_HUMAN
NC score	0.057658 (rank : 403)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	409	Target Neighborhood Hits	274	Shared Neighborhood Hits	37
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

AFF1_HUMAN
NC score	0.057592 (rank : 404)	θ value	1.38821 (rank : 245)
Query Neighborhood Hits	409	Target Neighborhood Hits	506	Shared Neighborhood Hits	50
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

SRRM1_MOUSE
NC score	0.057229 (rank : 405)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	409	Target Neighborhood Hits	966	Shared Neighborhood Hits	103
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

MPP4_HUMAN
NC score	0.057216 (rank : 406)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	409	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

KI67_HUMAN
NC score	0.055928 (rank : 407)	θ value	3.0926 (rank : 291)
Query Neighborhood Hits	409	Target Neighborhood Hits	581	Shared Neighborhood Hits	63
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

EP300_HUMAN
NC score	0.055397 (rank : 408)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	409	Target Neighborhood Hits	821	Shared Neighborhood Hits	70
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

GMIP_HUMAN
NC score	0.055270 (rank : 409)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	409	Target Neighborhood Hits	225	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

TCOF_MOUSE
NC score	0.055233 (rank : 410)	θ value	4.03905 (rank : 326)
Query Neighborhood Hits	409	Target Neighborhood Hits	471	Shared Neighborhood Hits	47
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

AFF4_HUMAN
NC score	0.055102 (rank : 411)	θ value	1.06291 (rank : 227)
Query Neighborhood Hits	409	Target Neighborhood Hits	611	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

CSKP_HUMAN
NC score	0.054750 (rank : 412)	θ value	5.27518 (rank : 335)
Query Neighborhood Hits	409	Target Neighborhood Hits	1022	Shared Neighborhood Hits	132
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
NC score	0.054264 (rank : 413)	θ value	4.03905 (rank : 309)
Query Neighborhood Hits	409	Target Neighborhood Hits	1027	Shared Neighborhood Hits	138
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

TXND2_HUMAN
NC score	0.054224 (rank : 414)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	409	Target Neighborhood Hits	793	Shared Neighborhood Hits	80
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

FES_HUMAN
NC score	0.054058 (rank : 415)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	409	Target Neighborhood Hits	978	Shared Neighborhood Hits	69
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

IWS1_MOUSE
NC score	0.053999 (rank : 416)	θ value	0.279714 (rank : 186)
Query Neighborhood Hits	409	Target Neighborhood Hits	1258	Shared Neighborhood Hits	93
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

S3TC2_MOUSE
NC score	0.053908 (rank : 417)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	409	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

FYB_HUMAN
NC score	0.053886 (rank : 418)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	409	Target Neighborhood Hits	379	Shared Neighborhood Hits	66
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

SOS1_MOUSE
NC score	0.053860 (rank : 419)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	409	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TGON2_HUMAN
NC score	0.053754 (rank : 420)	θ value	1.06291 (rank : 244)
Query Neighborhood Hits	409	Target Neighborhood Hits	1037	Shared Neighborhood Hits	89
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ILK_MOUSE
NC score	0.053543 (rank : 421)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	409	Target Neighborhood Hits	858	Shared Neighborhood Hits	60
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

EP15R_MOUSE
NC score	0.053462 (rank : 422)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	409	Target Neighborhood Hits	1135	Shared Neighborhood Hits	51
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

MLL2_HUMAN
NC score	0.053305 (rank : 423)	θ value	0.0961366 (rank : 161)
Query Neighborhood Hits	409	Target Neighborhood Hits	1788	Shared Neighborhood Hits	113
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ILK1_HUMAN
NC score	0.053300 (rank : 424)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	409	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
NC score	0.052921 (rank : 425)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	409	Target Neighborhood Hits	848	Shared Neighborhood Hits	59
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MDC1_MOUSE
NC score	0.052769 (rank : 426)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	409	Target Neighborhood Hits	998	Shared Neighborhood Hits	96
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MAP1B_MOUSE
NC score	0.052340 (rank : 427)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	409	Target Neighborhood Hits	977	Shared Neighborhood Hits	76
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

LMO7_HUMAN
NC score	0.052333 (rank : 428)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	409	Target Neighborhood Hits	507	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MAP1B_HUMAN
NC score	0.052209 (rank : 429)	θ value	8.99809 (rank : 398)
Query Neighborhood Hits	409	Target Neighborhood Hits	903	Shared Neighborhood Hits	74
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

BSN_MOUSE
NC score	0.052145 (rank : 430)	θ value	4.03905 (rank : 308)
Query Neighborhood Hits	409	Target Neighborhood Hits	2057	Shared Neighborhood Hits	148
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

TARA_HUMAN
NC score	0.052048 (rank : 431)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	409	Target Neighborhood Hits	1626	Shared Neighborhood Hits	122
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TACC2_HUMAN
NC score	0.051939 (rank : 432)	θ value	0.62314 (rank : 219)
Query Neighborhood Hits	409	Target Neighborhood Hits	856	Shared Neighborhood Hits	76
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

SRRM1_HUMAN
NC score	0.051858 (rank : 433)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	409	Target Neighborhood Hits	690	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

TAGAP_HUMAN
NC score	0.051825 (rank : 434)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	409	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

DLG2_MOUSE
NC score	0.051566 (rank : 435)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	409	Target Neighborhood Hits	271	Shared Neighborhood Hits	75
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

EP15_HUMAN
NC score	0.051551 (rank : 436)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	409	Target Neighborhood Hits	1021	Shared Neighborhood Hits	44
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
NC score	0.051210 (rank : 437)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	409	Target Neighborhood Hits	820	Shared Neighborhood Hits	31
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

SOCS1_MOUSE
NC score	0.050968 (rank : 438)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	409	Target Neighborhood Hits	82	Shared Neighborhood Hits	29
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

FES_MOUSE
NC score	0.050750 (rank : 439)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	409	Target Neighborhood Hits	980	Shared Neighborhood Hits	63
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MIA_HUMAN
NC score	0.050591 (rank : 440)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	409	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

RGAP1_MOUSE
NC score	0.050522 (rank : 441)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	409	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

MILK1_HUMAN
NC score	0.050362 (rank : 442)	θ value	0.00869519 (rank : 119)
Query Neighborhood Hits	409	Target Neighborhood Hits	427	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SOCS1_HUMAN
NC score	0.050273 (rank : 443)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	409	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

RHG06_HUMAN
NC score	0.050197 (rank : 444)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	409	Target Neighborhood Hits	114	Shared Neighborhood Hits	25
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

DLG2_HUMAN
NC score	0.050140 (rank : 445)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	409	Target Neighborhood Hits	279	Shared Neighborhood Hits	75
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

MIA_MOUSE
NC score	0.050075 (rank : 446)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	409	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

STAR8_HUMAN
NC score	0.048817 (rank : 447)	θ value	2.36792 (rank : 283)
Query Neighborhood Hits	409	Target Neighborhood Hits	216	Shared Neighborhood Hits	32
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CN155_HUMAN
NC score	0.047910 (rank : 448)	θ value	6.88961 (rank : 362)
Query Neighborhood Hits	409	Target Neighborhood Hits	385	Shared Neighborhood Hits	45
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

AFF1_MOUSE
NC score	0.047045 (rank : 449)	θ value	4.03905 (rank : 307)
Query Neighborhood Hits	409	Target Neighborhood Hits	351	Shared Neighborhood Hits	47
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

NFH_MOUSE
NC score	0.047013 (rank : 450)	θ value	0.0431538 (rank : 142)
Query Neighborhood Hits	409	Target Neighborhood Hits	2247	Shared Neighborhood Hits	147
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

MAP1A_HUMAN
NC score	0.046482 (rank : 451)	θ value	8.99809 (rank : 397)
Query Neighborhood Hits	409	Target Neighborhood Hits	1626	Shared Neighborhood Hits	106
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

BAZ2A_MOUSE
NC score	0.045068 (rank : 452)	θ value	0.62314 (rank : 207)
Query Neighborhood Hits	409	Target Neighborhood Hits	744	Shared Neighborhood Hits	72
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

ANK2_HUMAN
NC score	0.044597 (rank : 453)	θ value	0.0736092 (rank : 149)
Query Neighborhood Hits	409	Target Neighborhood Hits	1615	Shared Neighborhood Hits	126
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ATX2_MOUSE
NC score	0.044445 (rank : 454)	θ value	0.163984 (rank : 173)
Query Neighborhood Hits	409	Target Neighborhood Hits	445	Shared Neighborhood Hits	49
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

BRD4_HUMAN
NC score	0.043347 (rank : 455)	θ value	1.81305 (rank : 259)
Query Neighborhood Hits	409	Target Neighborhood Hits	851	Shared Neighborhood Hits	72
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CRTC1_HUMAN
NC score	0.042586 (rank : 456)	θ value	0.47712 (rank : 199)
Query Neighborhood Hits	409	Target Neighborhood Hits	319	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

PPRB_MOUSE
NC score	0.042478 (rank : 457)	θ value	0.62314 (rank : 217)
Query Neighborhood Hits	409	Target Neighborhood Hits	354	Shared Neighborhood Hits	42
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

MKL1_HUMAN
NC score	0.041880 (rank : 458)	θ value	1.81305 (rank : 263)
Query Neighborhood Hits	409	Target Neighborhood Hits	232	Shared Neighborhood Hits	28
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

PRG4_MOUSE
NC score	0.040140 (rank : 459)	θ value	3.0926 (rank : 293)
Query Neighborhood Hits	409	Target Neighborhood Hits	624	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

MLL3_HUMAN
NC score	0.039988 (rank : 460)	θ value	8.99809 (rank : 399)
Query Neighborhood Hits	409	Target Neighborhood Hits	1644	Shared Neighborhood Hits	111
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ERC2_MOUSE
NC score	0.038927 (rank : 461)	θ value	1.06291 (rank : 233)
Query Neighborhood Hits	409	Target Neighborhood Hits	1166	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

GON4L_MOUSE
NC score	0.038693 (rank : 462)	θ value	1.38821 (rank : 247)
Query Neighborhood Hits	409	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

RERE_HUMAN
NC score	0.038692 (rank : 463)	θ value	5.27518 (rank : 346)
Query Neighborhood Hits	409	Target Neighborhood Hits	779	Shared Neighborhood Hits	69
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

GOGA4_HUMAN
NC score	0.038573 (rank : 464)	θ value	0.813845 (rank : 221)
Query Neighborhood Hits	409	Target Neighborhood Hits	2034	Shared Neighborhood Hits	96
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

RERE_MOUSE
NC score	0.038114 (rank : 465)	θ value	4.03905 (rank : 322)
Query Neighborhood Hits	409	Target Neighborhood Hits	785	Shared Neighborhood Hits	71
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

NCOR2_HUMAN
NC score	0.037892 (rank : 466)	θ value	8.99809 (rank : 402)
Query Neighborhood Hits	409	Target Neighborhood Hits	870	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

PARG_HUMAN
NC score	0.037282 (rank : 467)	θ value	0.21417 (rank : 180)
Query Neighborhood Hits	409	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W56, Q6E4P6, Q6E4P7, Q7Z742, Q9Y4W7	Gene names	PARG
Domain Architecture	No domain graphic available
Description	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143).

WNK2_HUMAN
NC score	0.036277 (rank : 468)	θ value	5.27518 (rank : 353)
Query Neighborhood Hits	409	Target Neighborhood Hits	1407	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

GGN_HUMAN
NC score	0.035928 (rank : 469)	θ value	6.88961 (rank : 368)
Query Neighborhood Hits	409	Target Neighborhood Hits	269	Shared Neighborhood Hits	34
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

ANR11_HUMAN
NC score	0.035675 (rank : 470)	θ value	5.27518 (rank : 331)
Query Neighborhood Hits	409	Target Neighborhood Hits	1289	Shared Neighborhood Hits	97
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

K0460_MOUSE
NC score	0.035385 (rank : 471)	θ value	1.81305 (rank : 261)
Query Neighborhood Hits	409	Target Neighborhood Hits	374	Shared Neighborhood Hits	41
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

ERC2_HUMAN
NC score	0.035269 (rank : 472)	θ value	1.38821 (rank : 246)
Query Neighborhood Hits	409	Target Neighborhood Hits	1156	Shared Neighborhood Hits	53
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

GON4L_HUMAN
NC score	0.035244 (rank : 473)	θ value	4.03905 (rank : 314)
Query Neighborhood Hits	409	Target Neighborhood Hits	555	Shared Neighborhood Hits	48
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

WIRE_MOUSE
NC score	0.034358 (rank : 474)	θ value	5.27518 (rank : 352)
Query Neighborhood Hits	409	Target Neighborhood Hits	310	Shared Neighborhood Hits	37
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

MX1_MOUSE
NC score	0.034313 (rank : 475)	θ value	0.0736092 (rank : 152)
Query Neighborhood Hits	409	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

CENPF_HUMAN
NC score	0.033749 (rank : 476)	θ value	3.0926 (rank : 287)
Query Neighborhood Hits	409	Target Neighborhood Hits	1932	Shared Neighborhood Hits	90
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

BAZ2A_HUMAN
NC score	0.033669 (rank : 477)	θ value	5.27518 (rank : 333)
Query Neighborhood Hits	409	Target Neighborhood Hits	780	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

NOP14_HUMAN
NC score	0.033077 (rank : 478)	θ value	1.81305 (rank : 264)
Query Neighborhood Hits	409	Target Neighborhood Hits	573	Shared Neighborhood Hits	30
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

SYN3_MOUSE
NC score	0.032734 (rank : 479)	θ value	0.279714 (rank : 191)
Query Neighborhood Hits	409	Target Neighborhood Hits	200	Shared Neighborhood Hits	29
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

AUTS2_HUMAN
NC score	0.032456 (rank : 480)	θ value	5.27518 (rank : 332)
Query Neighborhood Hits	409	Target Neighborhood Hits	342	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

RIMS1_HUMAN
NC score	0.032383 (rank : 481)	θ value	1.38821 (rank : 249)
Query Neighborhood Hits	409	Target Neighborhood Hits	437	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

COX10_MOUSE
NC score	0.031873 (rank : 482)	θ value	0.62314 (rank : 210)
Query Neighborhood Hits	409	Target Neighborhood Hits	39	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFY5	Gene names	Cox10
Domain Architecture	No domain graphic available
Description	Protoheme IX farnesyltransferase, mitochondrial precursor (EC 2.5.1.-) (Heme O synthase).

SFR15_HUMAN
NC score	0.031548 (rank : 483)	θ value	2.36792 (rank : 281)
Query Neighborhood Hits	409	Target Neighborhood Hits	368	Shared Neighborhood Hits	28
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

MAP9_MOUSE
NC score	0.030485 (rank : 484)	θ value	4.03905 (rank : 318)
Query Neighborhood Hits	409	Target Neighborhood Hits	529	Shared Neighborhood Hits	37
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

PSIP1_MOUSE
NC score	0.030349 (rank : 485)	θ value	0.47712 (rank : 203)
Query Neighborhood Hits	409	Target Neighborhood Hits	313	Shared Neighborhood Hits	24
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

M3K3_MOUSE
NC score	0.029195 (rank : 486)	θ value	0.279714 (rank : 188)
Query Neighborhood Hits	409	Target Neighborhood Hits	876	Shared Neighborhood Hits	52
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

CO039_MOUSE
NC score	0.028846 (rank : 487)	θ value	6.88961 (rank : 363)
Query Neighborhood Hits	409	Target Neighborhood Hits	445	Shared Neighborhood Hits	58
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

M3K3_HUMAN
NC score	0.028482 (rank : 488)	θ value	1.81305 (rank : 262)
Query Neighborhood Hits	409	Target Neighborhood Hits	885	Shared Neighborhood Hits	55
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

CTRO_HUMAN
NC score	0.028302 (rank : 489)	θ value	6.88961 (rank : 366)
Query Neighborhood Hits	409	Target Neighborhood Hits	2092	Shared Neighborhood Hits	103
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

SYAP1_MOUSE
NC score	0.026904 (rank : 490)	θ value	4.03905 (rank : 324)
Query Neighborhood Hits	409	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D5V6, Q3UI67, Q9D870	Gene names	Syap1
Domain Architecture
Description	Synapse-associated protein 1.

SYNJ1_MOUSE
NC score	0.026801 (rank : 491)	θ value	4.03905 (rank : 325)
Query Neighborhood Hits	409	Target Neighborhood Hits	516	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

CD2L5_HUMAN
NC score	0.026792 (rank : 492)	θ value	3.0926 (rank : 286)
Query Neighborhood Hits	409	Target Neighborhood Hits	987	Shared Neighborhood Hits	64
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
NC score	0.026543 (rank : 493)	θ value	8.99809 (rank : 389)
Query Neighborhood Hits	409	Target Neighborhood Hits	1011	Shared Neighborhood Hits	70
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

DNL1_HUMAN
NC score	0.026533 (rank : 494)	θ value	4.03905 (rank : 311)
Query Neighborhood Hits	409	Target Neighborhood Hits	216	Shared Neighborhood Hits	29
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

ANKS6_HUMAN
NC score	0.025717 (rank : 495)	θ value	0.21417 (rank : 176)
Query Neighborhood Hits	409	Target Neighborhood Hits	411	Shared Neighborhood Hits	30
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

SPR1B_MOUSE
NC score	0.025556 (rank : 496)	θ value	3.0926 (rank : 298)
Query Neighborhood Hits	409	Target Neighborhood Hits	395	Shared Neighborhood Hits	40
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

MAST4_HUMAN
NC score	0.025504 (rank : 497)	θ value	0.813845 (rank : 223)
Query Neighborhood Hits	409	Target Neighborhood Hits	1804	Shared Neighborhood Hits	137
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SPEG_HUMAN
NC score	0.025350 (rank : 498)	θ value	3.0926 (rank : 297)
Query Neighborhood Hits	409	Target Neighborhood Hits	1762	Shared Neighborhood Hits	109
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

K1949_MOUSE
NC score	0.024534 (rank : 499)	θ value	2.36792 (rank : 279)
Query Neighborhood Hits	409	Target Neighborhood Hits	134	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

ARNT_MOUSE
NC score	0.024254 (rank : 500)	θ value	0.0961366 (rank : 154)
Query Neighborhood Hits	409	Target Neighborhood Hits	213	Shared Neighborhood Hits	21
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ADDB_HUMAN
NC score	0.024114 (rank : 501)	θ value	0.365318 (rank : 192)
Query Neighborhood Hits	409	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	P35612, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691	Gene names	ADD2, ADDB
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta).

TTC15_HUMAN
NC score	0.024021 (rank : 502)	θ value	6.88961 (rank : 384)
Query Neighborhood Hits	409	Target Neighborhood Hits	112	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WVT3, Q8WVW1, Q9Y395	Gene names	TTC15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

ATF2_MOUSE
NC score	0.023998 (rank : 503)	θ value	1.06291 (rank : 229)
Query Neighborhood Hits	409	Target Neighborhood Hits	397	Shared Neighborhood Hits	27
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

SYEP_HUMAN
NC score	0.023995 (rank : 504)	θ value	1.38821 (rank : 254)
Query Neighborhood Hits	409	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

EF1D_MOUSE
NC score	0.023934 (rank : 505)	θ value	2.36792 (rank : 276)
Query Neighborhood Hits	409	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	P57776, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5	Gene names	Eef1d
Domain Architecture
Description	Elongation factor 1-delta (EF-1-delta).

MYCD_MOUSE
NC score	0.023809 (rank : 506)	θ value	8.99809 (rank : 401)
Query Neighborhood Hits	409	Target Neighborhood Hits	144	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

CTTB2_HUMAN
NC score	0.023567 (rank : 507)	θ value	2.36792 (rank : 274)
Query Neighborhood Hits	409	Target Neighborhood Hits	1061	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

LIPS_HUMAN
NC score	0.023544 (rank : 508)	θ value	8.99809 (rank : 394)
Query Neighborhood Hits	409	Target Neighborhood Hits	314	Shared Neighborhood Hits	42
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

TTC15_MOUSE
NC score	0.023444 (rank : 509)	θ value	3.0926 (rank : 301)
Query Neighborhood Hits	409	Target Neighborhood Hits	113	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K2L8, Q8BX27	Gene names	Ttc15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

FXR2_MOUSE
NC score	0.022976 (rank : 510)	θ value	1.06291 (rank : 235)
Query Neighborhood Hits	409	Target Neighborhood Hits	66	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

TTDN1_HUMAN
NC score	0.022962 (rank : 511)	θ value	3.0926 (rank : 302)
Query Neighborhood Hits	409	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TAP9	Gene names	TTDN1, C7orf11
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein.

ATF2_HUMAN
NC score	0.022807 (rank : 512)	θ value	2.36792 (rank : 272)
Query Neighborhood Hits	409	Target Neighborhood Hits	402	Shared Neighborhood Hits	27
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

PP4R1_MOUSE
NC score	0.022638 (rank : 513)	θ value	3.0926 (rank : 292)
Query Neighborhood Hits	409	Target Neighborhood Hits	94	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

MYT1_HUMAN
NC score	0.022573 (rank : 514)	θ value	0.62314 (rank : 216)
Query Neighborhood Hits	409	Target Neighborhood Hits	475	Shared Neighborhood Hits	25
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

EP400_MOUSE
NC score	0.022083 (rank : 515)	θ value	1.06291 (rank : 232)
Query Neighborhood Hits	409	Target Neighborhood Hits	592	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

FXR2_HUMAN
NC score	0.021804 (rank : 516)	θ value	1.06291 (rank : 234)
Query Neighborhood Hits	409	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

ANKS6_MOUSE
NC score	0.021768 (rank : 517)	θ value	2.36792 (rank : 271)
Query Neighborhood Hits	409	Target Neighborhood Hits	435	Shared Neighborhood Hits	29
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

RPGR_HUMAN
NC score	0.021284 (rank : 518)	θ value	1.81305 (rank : 266)
Query Neighborhood Hits	409	Target Neighborhood Hits	279	Shared Neighborhood Hits	27
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

MUC1_MOUSE
NC score	0.021066 (rank : 519)	θ value	6.88961 (rank : 375)
Query Neighborhood Hits	409	Target Neighborhood Hits	388	Shared Neighborhood Hits	28
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

BBX_MOUSE
NC score	0.020812 (rank : 520)	θ value	0.62314 (rank : 208)
Query Neighborhood Hits	409	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW5, Q3TZK1, Q6NXY8, Q6PEU3, Q8BQJ7, Q8C7E0, Q8CDQ0, Q8CDV1, Q8VI48, Q8VI49, Q8VI50, Q9CS94	Gene names	Bbx, Hbp2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).

ANKS1_MOUSE
NC score	0.020521 (rank : 521)	θ value	5.27518 (rank : 330)
Query Neighborhood Hits	409	Target Neighborhood Hits	453	Shared Neighborhood Hits	36
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ZO1_HUMAN
NC score	0.020467 (rank : 522)	θ value	3.0926 (rank : 304)
Query Neighborhood Hits	409	Target Neighborhood Hits	474	Shared Neighborhood Hits	58
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

TIP60_HUMAN
NC score	0.019639 (rank : 523)	θ value	3.0926 (rank : 299)
Query Neighborhood Hits	409	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q92993, O95624, Q13430, Q6GSE8, Q9BWK7	Gene names	HTATIP, TIP60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60) (HIV-1 Tat interactive protein) (cPLA(2)-interacting protein).

TIP60_MOUSE
NC score	0.018808 (rank : 524)	θ value	4.03905 (rank : 327)
Query Neighborhood Hits	409	Target Neighborhood Hits	95	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CHK4, Q8CGZ3, Q8CGZ4, Q8VIH0	Gene names	Htatip, Tip60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60).

PHLB1_MOUSE
NC score	0.018382 (rank : 525)	θ value	4.03905 (rank : 319)
Query Neighborhood Hits	409	Target Neighborhood Hits	678	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

ERN1_MOUSE
NC score	0.017996 (rank : 526)	θ value	8.99809 (rank : 392)
Query Neighborhood Hits	409	Target Neighborhood Hits	823	Shared Neighborhood Hits	46
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

I20L2_HUMAN
NC score	0.017932 (rank : 527)	θ value	3.0926 (rank : 289)
Query Neighborhood Hits	409	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H9L3, Q64KA2	Gene names	ISG20L2
Domain Architecture
Description	Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-).

DHX16_HUMAN
NC score	0.017551 (rank : 528)	θ value	1.06291 (rank : 230)
Query Neighborhood Hits	409	Target Neighborhood Hits	356	Shared Neighborhood Hits	21
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

ZCH11_HUMAN
NC score	0.017449 (rank : 529)	θ value	8.99809 (rank : 408)
Query Neighborhood Hits	409	Target Neighborhood Hits	278	Shared Neighborhood Hits	31
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

K0427_MOUSE
NC score	0.017316 (rank : 530)	θ value	2.36792 (rank : 278)
Query Neighborhood Hits	409	Target Neighborhood Hits	106	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PEE2	Gene names	Gm672
Domain Architecture	No domain graphic available
Description	Protein KIAA0427 homolog.

IL16_HUMAN
NC score	0.017223 (rank : 531)	θ value	1.06291 (rank : 237)
Query Neighborhood Hits	409	Target Neighborhood Hits	207	Shared Neighborhood Hits	20
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

CBL_MOUSE
NC score	0.017209 (rank : 532)	θ value	6.88961 (rank : 361)
Query Neighborhood Hits	409	Target Neighborhood Hits	426	Shared Neighborhood Hits	35
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

PO6F2_HUMAN
NC score	0.017174 (rank : 533)	θ value	1.06291 (rank : 241)
Query Neighborhood Hits	409	Target Neighborhood Hits	618	Shared Neighborhood Hits	39
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

GTF2I_MOUSE
NC score	0.016695 (rank : 534)	θ value	2.36792 (rank : 277)
Query Neighborhood Hits	409	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ESZ8, O54700, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9	Gene names	Gtf2i, Bap135, Diws1t
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135).

TBCD2_HUMAN
NC score	0.016517 (rank : 535)	θ value	1.81305 (rank : 267)
Query Neighborhood Hits	409	Target Neighborhood Hits	419	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

TNC6B_HUMAN
NC score	0.016396 (rank : 536)	θ value	4.03905 (rank : 328)
Query Neighborhood Hits	409	Target Neighborhood Hits	256	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

GIT2_MOUSE
NC score	0.016358 (rank : 537)	θ value	4.03905 (rank : 313)
Query Neighborhood Hits	409	Target Neighborhood Hits	323	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

MAML1_MOUSE
NC score	0.015931 (rank : 538)	θ value	8.99809 (rank : 396)
Query Neighborhood Hits	409	Target Neighborhood Hits	279	Shared Neighborhood Hits	29
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MOR2B_MOUSE
NC score	0.015858 (rank : 539)	θ value	1.06291 (rank : 239)
Query Neighborhood Hits	409	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C5W4, Q8CG24	Gene names	Morc2b, Tce6
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2B (TCE6).

DACH2_MOUSE
NC score	0.015791 (rank : 540)	θ value	3.0926 (rank : 288)
Query Neighborhood Hits	409	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q925Q8, Q8BMA0	Gene names	Dach2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

MUC24_HUMAN
NC score	0.015592 (rank : 541)	θ value	8.99809 (rank : 400)
Query Neighborhood Hits	409	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q04900, Q5JSU6	Gene names	CD164
Domain Architecture
Description	Putative mucin core protein 24 precursor (Multi-glycosylated core protein 24) (MGC-24) (MUC-24) (CD164 antigen).

SC24B_HUMAN
NC score	0.015127 (rank : 542)	θ value	3.0926 (rank : 295)
Query Neighborhood Hits	409	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	O95487	Gene names	SEC24B
Domain Architecture
Description	Protein transport protein Sec24B (SEC24-related protein B).

TRIPC_HUMAN
NC score	0.014671 (rank : 543)	θ value	6.88961 (rank : 383)
Query Neighborhood Hits	409	Target Neighborhood Hits	319	Shared Neighborhood Hits	33
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

ARNT_HUMAN
NC score	0.014609 (rank : 544)	θ value	6.88961 (rank : 360)
Query Neighborhood Hits	409	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

EAF2_MOUSE
NC score	0.014343 (rank : 545)	θ value	4.03905 (rank : 312)
Query Neighborhood Hits	409	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q91ZD6, Q7TN80, Q99KD2	Gene names	Eaf2, Festa, Traits
Domain Architecture	No domain graphic available
Description	ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein) (Ehrlich S-II transcriptional activator factor).

GRAM3_MOUSE
NC score	0.014326 (rank : 546)	θ value	5.27518 (rank : 338)
Query Neighborhood Hits	409	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PEM6	Gene names	Gramd3
Domain Architecture	No domain graphic available
Description	GRAM domain-containing protein 3.

RBM6_HUMAN
NC score	0.014311 (rank : 547)	θ value	6.88961 (rank : 380)
Query Neighborhood Hits	409	Target Neighborhood Hits	221	Shared Neighborhood Hits	15
SwissProt Accessions	P78332, O60549, O75524	Gene names	RBM6, DEF3
Domain Architecture
Description	RNA-binding protein 6 (RNA-binding motif protein 6) (RNA-binding protein DEF-3) (Lung cancer antigen NY-LU-12) (Protein G16).

K1914_HUMAN
NC score	0.014181 (rank : 548)	θ value	4.03905 (rank : 315)
Query Neighborhood Hits	409	Target Neighborhood Hits	255	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

DPOLZ_HUMAN
NC score	0.013834 (rank : 549)	θ value	8.99809 (rank : 391)
Query Neighborhood Hits	409	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

PHLA1_HUMAN
NC score	0.013321 (rank : 550)	θ value	6.88961 (rank : 377)
Query Neighborhood Hits	409	Target Neighborhood Hits	121	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

TMCC2_HUMAN
NC score	0.012894 (rank : 551)	θ value	5.27518 (rank : 351)
Query Neighborhood Hits	409	Target Neighborhood Hits	227	Shared Neighborhood Hits	14
SwissProt Accessions	O75069, Q6ZN09	Gene names	TMCC2, KIAA0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11).

5NT1B_MOUSE
NC score	0.012202 (rank : 552)	θ value	6.88961 (rank : 356)
Query Neighborhood Hits	409	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YE9, Q91Y48	Gene names	Nt5c1b, Airp
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

TOX_MOUSE
NC score	0.011922 (rank : 553)	θ value	3.0926 (rank : 300)
Query Neighborhood Hits	409	Target Neighborhood Hits	95	Shared Neighborhood Hits	7
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

K1267_MOUSE
NC score	0.011748 (rank : 554)	θ value	6.88961 (rank : 372)
Query Neighborhood Hits	409	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TG1, Q3TT88, Q3U5D8, Q3V3N3, Q7TMU3, Q80XP7, Q8R3L6, Q9D9G0	Gene names	Kiaa1267
Domain Architecture	No domain graphic available
Description	Protein KIAA1267.

BRWD1_MOUSE
NC score	0.011638 (rank : 555)	θ value	5.27518 (rank : 334)
Query Neighborhood Hits	409	Target Neighborhood Hits	478	Shared Neighborhood Hits	22
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

PAPPA_HUMAN
NC score	0.011252 (rank : 556)	θ value	1.38821 (rank : 248)
Query Neighborhood Hits	409	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

DACH2_HUMAN
NC score	0.011160 (rank : 557)	θ value	8.99809 (rank : 390)
Query Neighborhood Hits	409	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	Q96NX9, Q8NAY3, Q8ND17, Q96N55	Gene names	DACH2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

MITF_HUMAN
NC score	0.010557 (rank : 558)	θ value	5.27518 (rank : 341)
Query Neighborhood Hits	409	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

AMACR_MOUSE
NC score	0.010341 (rank : 559)	θ value	6.88961 (rank : 359)
Query Neighborhood Hits	409	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O09174, Q9DCW6	Gene names	Amacr, Macr1
Domain Architecture
Description	Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase).

NCOA1_HUMAN
NC score	0.010232 (rank : 560)	θ value	6.88961 (rank : 376)
Query Neighborhood Hits	409	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

H12_HUMAN
NC score	0.010049 (rank : 561)	θ value	6.88961 (rank : 369)
Query Neighborhood Hits	409	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	P16403	Gene names	HIST1H1C, H1F2
Domain Architecture
Description	Histone H1.2 (Histone H1d).

CO5A1_HUMAN
NC score	0.009963 (rank : 562)	θ value	6.88961 (rank : 364)
Query Neighborhood Hits	409	Target Neighborhood Hits	434	Shared Neighborhood Hits	28
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

COBA1_HUMAN
NC score	0.009914 (rank : 563)	θ value	0.62314 (rank : 209)
Query Neighborhood Hits	409	Target Neighborhood Hits	491	Shared Neighborhood Hits	21
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

SGOL2_HUMAN
NC score	0.009432 (rank : 564)	θ value	8.99809 (rank : 405)
Query Neighborhood Hits	409	Target Neighborhood Hits	207	Shared Neighborhood Hits	11
SwissProt Accessions	Q562F6, Q53RR9, Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3	Gene names	SGOL2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2 (Tripin).

PLXB1_HUMAN
NC score	0.008592 (rank : 565)	θ value	4.03905 (rank : 320)
Query Neighborhood Hits	409	Target Neighborhood Hits	360	Shared Neighborhood Hits	25
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

DUS16_HUMAN
NC score	0.007655 (rank : 566)	θ value	2.36792 (rank : 275)
Query Neighborhood Hits	409	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

ULE1B_HUMAN
NC score	0.007559 (rank : 567)	θ value	6.88961 (rank : 385)
Query Neighborhood Hits	409	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

JHD3A_HUMAN
NC score	0.007526 (rank : 568)	θ value	5.27518 (rank : 340)
Query Neighborhood Hits	409	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	O75164, Q5VVB1	Gene names	JMJD2A, JHDM3A, JMJD2, KIAA0677
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

COBA1_MOUSE
NC score	0.007337 (rank : 569)	θ value	6.88961 (rank : 365)
Query Neighborhood Hits	409	Target Neighborhood Hits	487	Shared Neighborhood Hits	22
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

INADL_HUMAN
NC score	0.007317 (rank : 570)	θ value	5.27518 (rank : 339)
Query Neighborhood Hits	409	Target Neighborhood Hits	260	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

JHD3A_MOUSE
NC score	0.006966 (rank : 571)	θ value	6.88961 (rank : 371)
Query Neighborhood Hits	409	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BW72, Q3UKM5, Q3UM81, Q3UWV2, Q6ZQ72, Q8K137	Gene names	Jmjd2a, Jhdm3a, Jmjd2, Kiaa0677
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

S12A6_MOUSE
NC score	0.006930 (rank : 572)	θ value	2.36792 (rank : 280)
Query Neighborhood Hits	409	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

DMXL1_HUMAN
NC score	0.006138 (rank : 573)	θ value	4.03905 (rank : 310)
Query Neighborhood Hits	409	Target Neighborhood Hits	259	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

THIKB_MOUSE
NC score	0.005948 (rank : 574)	θ value	6.88961 (rank : 382)
Query Neighborhood Hits	409	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCH0	Gene names	Acaa1b, Acaa1
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase B, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl- CoA thiolase B).

HLX1_HUMAN
NC score	0.005442 (rank : 575)	θ value	0.62314 (rank : 212)
Query Neighborhood Hits	409	Target Neighborhood Hits	370	Shared Neighborhood Hits	7
SwissProt Accessions	Q14774, Q15988	Gene names	HLX1
Domain Architecture
Description	Homeobox protein HLX1 (Homeobox protein HB24).

ZEP2_HUMAN
NC score	0.005227 (rank : 576)	θ value	1.38821 (rank : 255)
Query Neighborhood Hits	409	Target Neighborhood Hits	937	Shared Neighborhood Hits	43
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

KIRR3_MOUSE
NC score	0.004927 (rank : 577)	θ value	4.03905 (rank : 317)
Query Neighborhood Hits	409	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

KIRR3_HUMAN
NC score	0.004757 (rank : 578)	θ value	4.03905 (rank : 316)
Query Neighborhood Hits	409	Target Neighborhood Hits	302	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

RAD54_HUMAN
NC score	0.003638 (rank : 579)	θ value	6.88961 (rank : 379)
Query Neighborhood Hits	409	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q92698, Q6IUY3	Gene names	RAD54L, RAD54A
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54-like (EC 3.6.1.-) (RAD54 homolog) (hRAD54) (hHR54).

NMDE4_MOUSE
NC score	0.003419 (rank : 580)	θ value	8.99809 (rank : 404)
Query Neighborhood Hits	409	Target Neighborhood Hits	158	Shared Neighborhood Hits	16
SwissProt Accessions	Q03391	Gene names	Grin2d
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D).

DDX46_HUMAN
NC score	0.003333 (rank : 581)	θ value	6.88961 (rank : 367)
Query Neighborhood Hits	409	Target Neighborhood Hits	357	Shared Neighborhood Hits	21
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

BIG2_HUMAN
NC score	0.003277 (rank : 582)	θ value	8.99809 (rank : 388)
Query Neighborhood Hits	409	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

MAGD2_HUMAN
NC score	0.003049 (rank : 583)	θ value	8.99809 (rank : 395)
Query Neighborhood Hits	409	Target Neighborhood Hits	95	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UNF1, O76058, Q5BJF3, Q8NAL6, Q9H218, Q9P0U9, Q9UM52	Gene names	MAGED2, BCG1
Domain Architecture
Description	Melanoma-associated antigen D2 (MAGE-D2 antigen) (MAGE-D) (Breast cancer-associated gene 1 protein) (BCG-1) (11B6) (Hepatocellular carcinoma-associated protein JCL-1).

NKX61_MOUSE
NC score	0.002822 (rank : 584)	θ value	5.27518 (rank : 344)
Query Neighborhood Hits	409	Target Neighborhood Hits	439	Shared Neighborhood Hits	16
SwissProt Accessions	Q99MA9, Q9ERQ7	Gene names	Nkx6-1, Nkx6.1, Nkx6a
Domain Architecture
Description	Homeobox protein Nkx-6.1.

ICAM5_MOUSE
NC score	0.002801 (rank : 585)	θ value	3.0926 (rank : 290)
Query Neighborhood Hits	409	Target Neighborhood Hits	308	Shared Neighborhood Hits	6
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

ZEP2_MOUSE
NC score	0.002443 (rank : 586)	θ value	8.99809 (rank : 409)
Query Neighborhood Hits	409	Target Neighborhood Hits	964	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

NKX61_HUMAN
NC score	0.002281 (rank : 587)	θ value	8.99809 (rank : 403)
Query Neighborhood Hits	409	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	P78426	Gene names	NKX6-1, NKX6A
Domain Architecture
Description	Homeobox protein Nkx-6.1.

HXA3_HUMAN
NC score	0.002111 (rank : 588)	θ value	6.88961 (rank : 370)
Query Neighborhood Hits	409	Target Neighborhood Hits	535	Shared Neighborhood Hits	30
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

ADA19_HUMAN
NC score	0.001426 (rank : 589)	θ value	4.03905 (rank : 306)
Query Neighborhood Hits	409	Target Neighborhood Hits	381	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

SREC2_HUMAN
NC score	0.000993 (rank : 590)	θ value	8.99809 (rank : 406)
Query Neighborhood Hits	409	Target Neighborhood Hits	645	Shared Neighborhood Hits	24
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

ZSCA5_HUMAN
NC score	-0.001548 (rank : 591)	θ value	0.125558 (rank : 171)
Query Neighborhood Hits	409	Target Neighborhood Hits	862	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BUG6	Gene names	ZSCAN5, ZNF495
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 5 (Zinc finger protein 495).

PRDM1_HUMAN
NC score	-0.002392 (rank : 592)	θ value	0.125558 (rank : 168)
Query Neighborhood Hits	409	Target Neighborhood Hits	734	Shared Neighborhood Hits	13
SwissProt Accessions	O75626	Gene names	PRDM1, BLIMP1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1) (Positive regulatory domain I-binding factor 1) (PRDI- binding factor 1) (PRDI-BF1).

BC11A_MOUSE
NC score	-0.003552 (rank : 593)	θ value	8.99809 (rank : 387)
Query Neighborhood Hits	409	Target Neighborhood Hits	732	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QYE3, Q80T89, Q8BLC7, Q8BLR4, Q8BWX3, Q921V4, Q9D0V2, Q9JIT4, Q9JLK8, Q9JLK9	Gene names	Bcl11a, Ctip1, Evi9, Kiaa1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

BC11A_HUMAN
NC score	-0.004307 (rank : 594)	θ value	8.99809 (rank : 386)
Query Neighborhood Hits	409	Target Neighborhood Hits	745	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H165, Q86W14, Q8WU92, Q96JL6, Q9H163, Q9H164, Q9H3G9, Q9NWA7	Gene names	BCL11A, CTIP1, EVI9, KIAA1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

PRDM1_MOUSE
NC score	-0.004428 (rank : 595)	θ value	6.88961 (rank : 378)
Query Neighborhood Hits	409	Target Neighborhood Hits	766	Shared Neighborhood Hits	14
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

ZBT11_HUMAN
NC score	-0.005785 (rank : 596)	θ value	3.0926 (rank : 303)
Query Neighborhood Hits	409	Target Neighborhood Hits	873	Shared Neighborhood Hits	19
SwissProt Accessions	O95625	Gene names	ZBTB11
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 11.

ZN319_HUMAN
NC score	-0.005877 (rank : 597)	θ value	1.38821 (rank : 256)
Query Neighborhood Hits	409	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2F9	Gene names	ZNF319, KIAA1388
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ZN596_HUMAN
NC score	-0.007016 (rank : 598)	θ value	5.27518 (rank : 355)
Query Neighborhood Hits	409	Target Neighborhood Hits	716	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TC21, O95015, Q8N9X0	Gene names	ZNF596
Domain Architecture	No domain graphic available
Description	Zinc finger protein 596.

ZN133_HUMAN
NC score	-0.007027 (rank : 599)	θ value	5.27518 (rank : 354)
Query Neighborhood Hits	409	Target Neighborhood Hits	784	Shared Neighborhood Hits	16
SwissProt Accessions	P52736, Q9BUV2, Q9H443	Gene names	ZNF133
Domain Architecture
Description	Zinc finger protein 133.