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Network neighborhood for query Sequence : JIP2_MOUSE

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JIP2_MOUSE
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

JIP2_HUMAN
θ value	0 (rank : 1)	NC score	0.941773 (rank : 2)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	99
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	144	Target Neighborhood Hits	144	Shared Neighborhood Hits	144
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP1_HUMAN
θ value	1.26366e-94 (rank : 3)	NC score	0.845016 (rank : 3)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	2.81514e-94 (rank : 4)	NC score	0.844062 (rank : 4)
Query Neighborhood Hits	144	Target Neighborhood Hits	259	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

BAZ2A_MOUSE
θ value	0.00020696 (rank : 5)	NC score	0.064829 (rank : 107)
Query Neighborhood Hits	144	Target Neighborhood Hits	744	Shared Neighborhood Hits	28
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

VINEX_MOUSE
θ value	0.00020696 (rank : 6)	NC score	0.255131 (rank : 5)
Query Neighborhood Hits	144	Target Neighborhood Hits	286	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
θ value	0.000270298 (rank : 7)	NC score	0.254088 (rank : 6)
Query Neighborhood Hits	144	Target Neighborhood Hits	270	Shared Neighborhood Hits	63
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SRBS1_HUMAN
θ value	0.000461057 (rank : 8)	NC score	0.241616 (rank : 7)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	0.000602161 (rank : 9)	NC score	0.237662 (rank : 8)
Query Neighborhood Hits	144	Target Neighborhood Hits	409	Shared Neighborhood Hits	67
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ANKS1_HUMAN
θ value	0.00175202 (rank : 10)	NC score	0.083774 (rank : 61)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	21
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	0.00175202 (rank : 11)	NC score	0.089174 (rank : 51)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

DCC_MOUSE
θ value	0.00298849 (rank : 12)	NC score	0.036278 (rank : 168)
Query Neighborhood Hits	144	Target Neighborhood Hits	896	Shared Neighborhood Hits	18
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

ARHG5_HUMAN
θ value	0.00390308 (rank : 13)	NC score	0.171759 (rank : 12)
Query Neighborhood Hits	144	Target Neighborhood Hits	172	Shared Neighborhood Hits	49
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

STS2_HUMAN
θ value	0.00665767 (rank : 14)	NC score	0.198983 (rank : 9)
Query Neighborhood Hits	144	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ARHGG_MOUSE
θ value	0.00869519 (rank : 15)	NC score	0.131386 (rank : 22)
Query Neighborhood Hits	144	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

TNR11_HUMAN
θ value	0.00869519 (rank : 16)	NC score	0.049906 (rank : 159)
Query Neighborhood Hits	144	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6Q6	Gene names	TNFRSF11A, RANK
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen).

DDEF2_HUMAN
θ value	0.0113563 (rank : 17)	NC score	0.103465 (rank : 40)
Query Neighborhood Hits	144	Target Neighborhood Hits	599	Shared Neighborhood Hits	64
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

LEO1_HUMAN
θ value	0.0193708 (rank : 18)	NC score	0.052259 (rank : 152)
Query Neighborhood Hits	144	Target Neighborhood Hits	958	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

DOCK1_HUMAN
θ value	0.0252991 (rank : 19)	NC score	0.096034 (rank : 46)
Query Neighborhood Hits	144	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

PAF49_MOUSE
θ value	0.0252991 (rank : 20)	NC score	0.085303 (rank : 58)
Query Neighborhood Hits	144	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q76KJ5, Q8K0Y9	Gene names	Cd3eap, Ase1, Paf49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein).

DDEF2_MOUSE
θ value	0.0330416 (rank : 21)	NC score	0.101724 (rank : 41)
Query Neighborhood Hits	144	Target Neighborhood Hits	625	Shared Neighborhood Hits	67
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

LASP1_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.172942 (rank : 10)
Query Neighborhood Hits	144	Target Neighborhood Hits	293	Shared Neighborhood Hits	59
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.0330416 (rank : 23)	NC score	0.172529 (rank : 11)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	59
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SON_HUMAN
θ value	0.0330416 (rank : 24)	NC score	0.035141 (rank : 170)
Query Neighborhood Hits	144	Target Neighborhood Hits	1568	Shared Neighborhood Hits	31
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

LEO1_MOUSE
θ value	0.0431538 (rank : 25)	NC score	0.059557 (rank : 124)
Query Neighborhood Hits	144	Target Neighborhood Hits	946	Shared Neighborhood Hits	17
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

PPIP1_HUMAN
θ value	0.0736092 (rank : 26)	NC score	0.169223 (rank : 13)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	60
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SNX18_MOUSE
θ value	0.0736092 (rank : 27)	NC score	0.136292 (rank : 19)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	54
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BRCA1_MOUSE
θ value	0.0961366 (rank : 28)	NC score	0.053979 (rank : 139)
Query Neighborhood Hits	144	Target Neighborhood Hits	436	Shared Neighborhood Hits	7
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

DNMBP_HUMAN
θ value	0.0961366 (rank : 29)	NC score	0.140097 (rank : 17)
Query Neighborhood Hits	144	Target Neighborhood Hits	413	Shared Neighborhood Hits	64
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NBEA_MOUSE
θ value	0.0961366 (rank : 30)	NC score	0.029504 (rank : 174)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

NEK9_MOUSE
θ value	0.0961366 (rank : 31)	NC score	0.009609 (rank : 211)
Query Neighborhood Hits	144	Target Neighborhood Hits	890	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NGEF_HUMAN
θ value	0.0961366 (rank : 32)	NC score	0.111398 (rank : 31)
Query Neighborhood Hits	144	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SNX18_HUMAN
θ value	0.0961366 (rank : 33)	NC score	0.133603 (rank : 21)
Query Neighborhood Hits	144	Target Neighborhood Hits	207	Shared Neighborhood Hits	54
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SPN90_MOUSE
θ value	0.125558 (rank : 34)	NC score	0.107379 (rank : 36)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ZN516_MOUSE
θ value	0.125558 (rank : 35)	NC score	0.012012 (rank : 207)
Query Neighborhood Hits	144	Target Neighborhood Hits	1197	Shared Neighborhood Hits	23
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

APXL_HUMAN
θ value	0.163984 (rank : 36)	NC score	0.045519 (rank : 161)
Query Neighborhood Hits	144	Target Neighborhood Hits	553	Shared Neighborhood Hits	15
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

BSN_MOUSE
θ value	0.163984 (rank : 37)	NC score	0.060168 (rank : 122)
Query Neighborhood Hits	144	Target Neighborhood Hits	2057	Shared Neighborhood Hits	48
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

DNMBP_MOUSE
θ value	0.21417 (rank : 38)	NC score	0.130191 (rank : 23)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NGEF_MOUSE
θ value	0.21417 (rank : 39)	NC score	0.113309 (rank : 27)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ACK1_HUMAN
θ value	0.279714 (rank : 40)	NC score	0.021043 (rank : 185)
Query Neighborhood Hits	144	Target Neighborhood Hits	1140	Shared Neighborhood Hits	34
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	0.279714 (rank : 41)	NC score	0.021618 (rank : 183)
Query Neighborhood Hits	144	Target Neighborhood Hits	1080	Shared Neighborhood Hits	41
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

NEBL_HUMAN
θ value	0.279714 (rank : 42)	NC score	0.136812 (rank : 18)
Query Neighborhood Hits	144	Target Neighborhood Hits	457	Shared Neighborhood Hits	63
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

OSTF1_HUMAN
θ value	0.279714 (rank : 43)	NC score	0.124846 (rank : 24)
Query Neighborhood Hits	144	Target Neighborhood Hits	466	Shared Neighborhood Hits	59
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

RGS3_MOUSE
θ value	0.279714 (rank : 44)	NC score	0.055877 (rank : 133)
Query Neighborhood Hits	144	Target Neighborhood Hits	1621	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BSN_HUMAN
θ value	0.365318 (rank : 45)	NC score	0.067876 (rank : 97)
Query Neighborhood Hits	144	Target Neighborhood Hits	1537	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CD2AP_HUMAN
θ value	0.365318 (rank : 46)	NC score	0.156517 (rank : 15)
Query Neighborhood Hits	144	Target Neighborhood Hits	315	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

MYO1F_MOUSE
θ value	0.365318 (rank : 47)	NC score	0.055156 (rank : 137)
Query Neighborhood Hits	144	Target Neighborhood Hits	262	Shared Neighborhood Hits	53
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SIG12_MOUSE
θ value	0.365318 (rank : 48)	NC score	0.031724 (rank : 172)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

TBX2_HUMAN
θ value	0.365318 (rank : 49)	NC score	0.017445 (rank : 194)
Query Neighborhood Hits	144	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

OSTF1_MOUSE
θ value	0.47712 (rank : 50)	NC score	0.117381 (rank : 26)
Query Neighborhood Hits	144	Target Neighborhood Hits	467	Shared Neighborhood Hits	59
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

TB182_HUMAN
θ value	0.47712 (rank : 51)	NC score	0.057414 (rank : 131)
Query Neighborhood Hits	144	Target Neighborhood Hits	414	Shared Neighborhood Hits	18
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

GLI2_HUMAN
θ value	0.62314 (rank : 52)	NC score	0.004629 (rank : 220)
Query Neighborhood Hits	144	Target Neighborhood Hits	971	Shared Neighborhood Hits	12
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

KCNQ5_HUMAN
θ value	0.62314 (rank : 53)	NC score	0.017011 (rank : 195)
Query Neighborhood Hits	144	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

MYO1F_HUMAN
θ value	0.62314 (rank : 54)	NC score	0.053851 (rank : 141)
Query Neighborhood Hits	144	Target Neighborhood Hits	275	Shared Neighborhood Hits	54
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

PPIP1_MOUSE
θ value	0.62314 (rank : 55)	NC score	0.157357 (rank : 14)
Query Neighborhood Hits	144	Target Neighborhood Hits	377	Shared Neighborhood Hits	60
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SAPS1_HUMAN
θ value	0.62314 (rank : 56)	NC score	0.039447 (rank : 165)
Query Neighborhood Hits	144	Target Neighborhood Hits	704	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SH3K1_MOUSE
θ value	0.62314 (rank : 57)	NC score	0.134219 (rank : 20)
Query Neighborhood Hits	144	Target Neighborhood Hits	332	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

OXR1_MOUSE
θ value	0.813845 (rank : 58)	NC score	0.028452 (rank : 177)
Query Neighborhood Hits	144	Target Neighborhood Hits	516	Shared Neighborhood Hits	13
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

P85A_MOUSE
θ value	0.813845 (rank : 59)	NC score	0.072066 (rank : 85)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	43
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

VINC_HUMAN
θ value	0.813845 (rank : 60)	NC score	0.028238 (rank : 178)
Query Neighborhood Hits	144	Target Neighborhood Hits	145	Shared Neighborhood Hits	6
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

YTHD1_HUMAN
θ value	0.813845 (rank : 61)	NC score	0.036972 (rank : 167)
Query Neighborhood Hits	144	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYJ9, Q8N3G5, Q8TBT1, Q96AN4, Q96S57, Q9BTI7, Q9NX79	Gene names	YTHDF1, C20orf21
Domain Architecture
Description	YTH domain family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1).

CAC1B_MOUSE
θ value	1.06291 (rank : 62)	NC score	0.020630 (rank : 187)
Query Neighborhood Hits	144	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

LATS2_HUMAN
θ value	1.06291 (rank : 63)	NC score	0.007461 (rank : 214)
Query Neighborhood Hits	144	Target Neighborhood Hits	884	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

SPEG_MOUSE
θ value	1.06291 (rank : 64)	NC score	0.019133 (rank : 190)
Query Neighborhood Hits	144	Target Neighborhood Hits	1959	Shared Neighborhood Hits	40
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPN90_HUMAN
θ value	1.06291 (rank : 65)	NC score	0.092885 (rank : 47)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

STAC_MOUSE
θ value	1.06291 (rank : 66)	NC score	0.112682 (rank : 29)
Query Neighborhood Hits	144	Target Neighborhood Hits	268	Shared Neighborhood Hits	50
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ANKS3_MOUSE
θ value	1.38821 (rank : 67)	NC score	0.022069 (rank : 182)
Query Neighborhood Hits	144	Target Neighborhood Hits	355	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

EVI1_MOUSE
θ value	1.38821 (rank : 68)	NC score	0.001243 (rank : 222)
Query Neighborhood Hits	144	Target Neighborhood Hits	826	Shared Neighborhood Hits	7
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

FUT8_HUMAN
θ value	1.38821 (rank : 69)	NC score	0.107601 (rank : 35)
Query Neighborhood Hits	144	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

ITSN1_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.076415 (rank : 79)
Query Neighborhood Hits	144	Target Neighborhood Hits	1757	Shared Neighborhood Hits	75
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PACN1_HUMAN
θ value	1.38821 (rank : 71)	NC score	0.112508 (rank : 30)
Query Neighborhood Hits	144	Target Neighborhood Hits	320	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	1.38821 (rank : 72)	NC score	0.112844 (rank : 28)
Query Neighborhood Hits	144	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ARHG6_HUMAN
θ value	1.81305 (rank : 73)	NC score	0.090477 (rank : 49)
Query Neighborhood Hits	144	Target Neighborhood Hits	376	Shared Neighborhood Hits	56
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARH_MOUSE
θ value	1.81305 (rank : 74)	NC score	0.109147 (rank : 34)
Query Neighborhood Hits	144	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

CN104_HUMAN
θ value	1.81305 (rank : 75)	NC score	0.057942 (rank : 129)
Query Neighborhood Hits	144	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NVR5, Q86TY8, Q969Z5	Gene names	C14orf104
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf104.

CSF1_HUMAN
θ value	1.81305 (rank : 76)	NC score	0.029088 (rank : 175)
Query Neighborhood Hits	144	Target Neighborhood Hits	258	Shared Neighborhood Hits	12
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

GRAP_MOUSE
θ value	1.81305 (rank : 77)	NC score	0.077661 (rank : 75)
Query Neighborhood Hits	144	Target Neighborhood Hits	309	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

HTSF1_HUMAN
θ value	1.81305 (rank : 78)	NC score	0.032676 (rank : 171)
Query Neighborhood Hits	144	Target Neighborhood Hits	408	Shared Neighborhood Hits	11
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

ITSN1_MOUSE
θ value	1.81305 (rank : 79)	NC score	0.076064 (rank : 80)
Query Neighborhood Hits	144	Target Neighborhood Hits	1669	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

KIF4A_MOUSE
θ value	1.81305 (rank : 80)	NC score	0.011046 (rank : 209)
Query Neighborhood Hits	144	Target Neighborhood Hits	1033	Shared Neighborhood Hits	22
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

OBSCN_HUMAN
θ value	1.81305 (rank : 81)	NC score	0.012596 (rank : 205)
Query Neighborhood Hits	144	Target Neighborhood Hits	1931	Shared Neighborhood Hits	33
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PI51C_HUMAN
θ value	1.81305 (rank : 82)	NC score	0.018309 (rank : 192)
Query Neighborhood Hits	144	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

SPEG_HUMAN
θ value	1.81305 (rank : 83)	NC score	0.023732 (rank : 180)
Query Neighborhood Hits	144	Target Neighborhood Hits	1762	Shared Neighborhood Hits	38
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

FUT8_MOUSE
θ value	2.36792 (rank : 84)	NC score	0.099754 (rank : 42)
Query Neighborhood Hits	144	Target Neighborhood Hits	115	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

NASP_HUMAN
θ value	2.36792 (rank : 85)	NC score	0.037763 (rank : 166)
Query Neighborhood Hits	144	Target Neighborhood Hits	709	Shared Neighborhood Hits	19
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

NCF2_HUMAN
θ value	2.36792 (rank : 86)	NC score	0.144471 (rank : 16)
Query Neighborhood Hits	144	Target Neighborhood Hits	229	Shared Neighborhood Hits	53
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NF2L1_MOUSE
θ value	2.36792 (rank : 87)	NC score	0.016018 (rank : 197)
Query Neighborhood Hits	144	Target Neighborhood Hits	185	Shared Neighborhood Hits	3
SwissProt Accessions	Q61985, O70234	Gene names	Nfe2l1, Nrf1
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1).

P85A_HUMAN
θ value	2.36792 (rank : 88)	NC score	0.062437 (rank : 117)
Query Neighborhood Hits	144	Target Neighborhood Hits	479	Shared Neighborhood Hits	42
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

US6NL_HUMAN
θ value	2.36792 (rank : 89)	NC score	0.016361 (rank : 196)
Query Neighborhood Hits	144	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

APBA1_HUMAN
θ value	3.0926 (rank : 90)	NC score	0.064602 (rank : 108)
Query Neighborhood Hits	144	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

ARHG7_HUMAN
θ value	3.0926 (rank : 91)	NC score	0.097460 (rank : 45)
Query Neighborhood Hits	144	Target Neighborhood Hits	347	Shared Neighborhood Hits	57
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CAC1E_MOUSE
θ value	3.0926 (rank : 92)	NC score	0.014705 (rank : 202)
Query Neighborhood Hits	144	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

DP13A_HUMAN
θ value	3.0926 (rank : 93)	NC score	0.071679 (rank : 88)
Query Neighborhood Hits	144	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	3.0926 (rank : 94)	NC score	0.071858 (rank : 86)
Query Neighborhood Hits	144	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

FRS3_MOUSE
θ value	3.0926 (rank : 95)	NC score	0.015820 (rank : 198)
Query Neighborhood Hits	144	Target Neighborhood Hits	168	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

MAGB6_HUMAN
θ value	3.0926 (rank : 96)	NC score	0.009754 (rank : 210)
Query Neighborhood Hits	144	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

PACN2_MOUSE
θ value	3.0926 (rank : 97)	NC score	0.109608 (rank : 33)
Query Neighborhood Hits	144	Target Neighborhood Hits	382	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.106762 (rank : 37)
Query Neighborhood Hits	144	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	3.0926 (rank : 99)	NC score	0.105563 (rank : 38)
Query Neighborhood Hits	144	Target Neighborhood Hits	380	Shared Neighborhood Hits	53
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SHC1_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.050831 (rank : 156)
Query Neighborhood Hits	144	Target Neighborhood Hits	170	Shared Neighborhood Hits	17
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	3.0926 (rank : 101)	NC score	0.053071 (rank : 145)
Query Neighborhood Hits	144	Target Neighborhood Hits	180	Shared Neighborhood Hits	20
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

VAV_MOUSE
θ value	3.0926 (rank : 102)	NC score	0.073447 (rank : 82)
Query Neighborhood Hits	144	Target Neighborhood Hits	430	Shared Neighborhood Hits	60
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG7_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.099478 (rank : 44)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CO039_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.029069 (rank : 176)
Query Neighborhood Hits	144	Target Neighborhood Hits	445	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

DMN_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.019408 (rank : 189)
Query Neighborhood Hits	144	Target Neighborhood Hits	690	Shared Neighborhood Hits	20
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

DP13B_HUMAN
θ value	4.03905 (rank : 106)	NC score	0.058811 (rank : 126)
Query Neighborhood Hits	144	Target Neighborhood Hits	58	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

GAK_HUMAN
θ value	4.03905 (rank : 107)	NC score	0.012330 (rank : 206)
Query Neighborhood Hits	144	Target Neighborhood Hits	1028	Shared Neighborhood Hits	18
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MAP1A_HUMAN
θ value	4.03905 (rank : 108)	NC score	0.024569 (rank : 179)
Query Neighborhood Hits	144	Target Neighborhood Hits	1626	Shared Neighborhood Hits	45
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MEFV_HUMAN
θ value	4.03905 (rank : 109)	NC score	0.005984 (rank : 217)
Query Neighborhood Hits	144	Target Neighborhood Hits	431	Shared Neighborhood Hits	8
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

PDXL2_MOUSE
θ value	4.03905 (rank : 110)	NC score	0.045611 (rank : 160)
Query Neighborhood Hits	144	Target Neighborhood Hits	213	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

POF1B_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.018845 (rank : 191)
Query Neighborhood Hits	144	Target Neighborhood Hits	494	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

STAC_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.099500 (rank : 43)
Query Neighborhood Hits	144	Target Neighborhood Hits	276	Shared Neighborhood Hits	52
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TXK_MOUSE
θ value	4.03905 (rank : 113)	NC score	0.018106 (rank : 193)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	54
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

APBA2_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.052132 (rank : 153)
Query Neighborhood Hits	144	Target Neighborhood Hits	220	Shared Neighborhood Hits	11
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.053783 (rank : 142)
Query Neighborhood Hits	144	Target Neighborhood Hits	219	Shared Neighborhood Hits	16
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

ASPP1_MOUSE
θ value	5.27518 (rank : 116)	NC score	0.042424 (rank : 163)
Query Neighborhood Hits	144	Target Neighborhood Hits	1244	Shared Neighborhood Hits	66
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

FREM3_MOUSE
θ value	5.27518 (rank : 117)	NC score	0.008504 (rank : 212)
Query Neighborhood Hits	144	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

GP124_MOUSE
θ value	5.27518 (rank : 118)	NC score	0.004897 (rank : 219)
Query Neighborhood Hits	144	Target Neighborhood Hits	423	Shared Neighborhood Hits	4
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

KI13A_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.007019 (rank : 215)
Query Neighborhood Hits	144	Target Neighborhood Hits	359	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H1H9, Q9H1H8	Gene names	KIF13A, RBKIN
Domain Architecture
Description	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN).

LN28B_HUMAN
θ value	5.27518 (rank : 120)	NC score	0.014851 (rank : 201)
Query Neighborhood Hits	144	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZN17	Gene names	LIN28B, CSDD2
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

NSBP1_MOUSE
θ value	5.27518 (rank : 121)	NC score	0.022517 (rank : 181)
Query Neighborhood Hits	144	Target Neighborhood Hits	681	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

POF1B_MOUSE
θ value	5.27518 (rank : 122)	NC score	0.015439 (rank : 199)
Query Neighborhood Hits	144	Target Neighborhood Hits	530	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

SNX9_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.080704 (rank : 65)
Query Neighborhood Hits	144	Target Neighborhood Hits	148	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

UBQL3_MOUSE
θ value	5.27518 (rank : 124)	NC score	0.011516 (rank : 208)
Query Neighborhood Hits	144	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C5U9	Gene names	Ubqln3
Domain Architecture
Description	Ubiquilin-3.

5HT6R_HUMAN
θ value	6.88961 (rank : 125)	NC score	-0.001560 (rank : 223)
Query Neighborhood Hits	144	Target Neighborhood Hits	882	Shared Neighborhood Hits	2
SwissProt Accessions	P50406, Q13640	Gene names	HTR6
Domain Architecture
Description	5-hydroxytryptamine 6 receptor (5-HT-6) (Serotonin receptor 6).

ES8L2_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.035766 (rank : 169)
Query Neighborhood Hits	144	Target Neighborhood Hits	169	Shared Neighborhood Hits	38
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

LATS2_MOUSE
θ value	6.88961 (rank : 127)	NC score	0.005378 (rank : 218)
Query Neighborhood Hits	144	Target Neighborhood Hits	879	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

MYST3_MOUSE
θ value	6.88961 (rank : 128)	NC score	0.021380 (rank : 184)
Query Neighborhood Hits	144	Target Neighborhood Hits	688	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

PACN2_HUMAN
θ value	6.88961 (rank : 129)	NC score	0.103810 (rank : 39)
Query Neighborhood Hits	144	Target Neighborhood Hits	339	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

TCAL5_HUMAN
θ value	6.88961 (rank : 130)	NC score	0.020809 (rank : 186)
Query Neighborhood Hits	144	Target Neighborhood Hits	806	Shared Neighborhood Hits	17
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

UBXD1_HUMAN
θ value	6.88961 (rank : 131)	NC score	0.014582 (rank : 203)
Query Neighborhood Hits	144	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZV1, Q96AH1, Q96IK9, Q9BZV0	Gene names	UBXD1, UBXDC2
Domain Architecture
Description	UBX domain-containing protein 1.

ZAR1_MOUSE
θ value	6.88961 (rank : 132)	NC score	0.019774 (rank : 188)
Query Neighborhood Hits	144	Target Neighborhood Hits	254	Shared Neighborhood Hits	9
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

CABIN_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.030289 (rank : 173)
Query Neighborhood Hits	144	Target Neighborhood Hits	490	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

DP13B_MOUSE
θ value	8.99809 (rank : 134)	NC score	0.053918 (rank : 140)
Query Neighborhood Hits	144	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

JHD3B_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.007629 (rank : 213)
Query Neighborhood Hits	144	Target Neighborhood Hits	128	Shared Neighborhood Hits	8
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

LAX1_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.014054 (rank : 204)
Query Neighborhood Hits	144	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWV1, Q6NSZ6, Q9NXB4	Gene names	LAX1, LAX
Domain Architecture	No domain graphic available
Description	Lymphocyte transmembrane adapter 1 (Membrane-associated adapter protein LAX) (Linker for activation of X cells).

LUZP1_MOUSE
θ value	8.99809 (rank : 137)	NC score	0.006930 (rank : 216)
Query Neighborhood Hits	144	Target Neighborhood Hits	940	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

P85B_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.045110 (rank : 162)
Query Neighborhood Hits	144	Target Neighborhood Hits	543	Shared Neighborhood Hits	33
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	8.99809 (rank : 139)	NC score	0.042193 (rank : 164)
Query Neighborhood Hits	144	Target Neighborhood Hits	519	Shared Neighborhood Hits	29
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PTN22_MOUSE
θ value	8.99809 (rank : 140)	NC score	0.002561 (rank : 221)
Query Neighborhood Hits	144	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

SH3K1_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.124814 (rank : 25)
Query Neighborhood Hits	144	Target Neighborhood Hits	341	Shared Neighborhood Hits	60
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SRC8_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.089162 (rank : 52)
Query Neighborhood Hits	144	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	8.99809 (rank : 143)	NC score	0.089743 (rank : 50)
Query Neighborhood Hits	144	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

TAU_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.015403 (rank : 200)
Query Neighborhood Hits	144	Target Neighborhood Hits	502	Shared Neighborhood Hits	16
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ABI1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.073615 (rank : 81)
Query Neighborhood Hits	144	Target Neighborhood Hits	257	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.080418 (rank : 67)
Query Neighborhood Hits	144	Target Neighborhood Hits	246	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.086231 (rank : 56)
Query Neighborhood Hits	144	Target Neighborhood Hits	350	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.082829 (rank : 62)
Query Neighborhood Hits	144	Target Neighborhood Hits	266	Shared Neighborhood Hits	53
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.078673 (rank : 74)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.070619 (rank : 92)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG4_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.052580 (rank : 148)
Query Neighborhood Hits	144	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.080257 (rank : 68)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGF_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.077115 (rank : 76)
Query Neighborhood Hits	144	Target Neighborhood Hits	214	Shared Neighborhood Hits	25
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.073027 (rank : 84)
Query Neighborhood Hits	144	Target Neighborhood Hits	129	Shared Neighborhood Hits	26
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARH_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.078971 (rank : 71)
Query Neighborhood Hits	144	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

BCAR1_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.052283 (rank : 150)
Query Neighborhood Hits	144	Target Neighborhood Hits	554	Shared Neighborhood Hits	58
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.051031 (rank : 155)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	57
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BIN1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.051268 (rank : 154)
Query Neighborhood Hits	144	Target Neighborhood Hits	335	Shared Neighborhood Hits	41
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

CAPON_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.076981 (rank : 77)
Query Neighborhood Hits	144	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CAPON_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.073277 (rank : 83)
Query Neighborhood Hits	144	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CD2AP_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.109888 (rank : 32)
Query Neighborhood Hits	144	Target Neighborhood Hits	336	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CRKL_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.064280 (rank : 110)
Query Neighborhood Hits	144	Target Neighborhood Hits	313	Shared Neighborhood Hits	51
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.063965 (rank : 112)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	51
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.076750 (rank : 78)
Query Neighborhood Hits	144	Target Neighborhood Hits	308	Shared Neighborhood Hits	55
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.079136 (rank : 70)
Query Neighborhood Hits	144	Target Neighborhood Hits	314	Shared Neighborhood Hits	55
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.052730 (rank : 146)
Query Neighborhood Hits	144	Target Neighborhood Hits	235	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.067478 (rank : 98)
Query Neighborhood Hits	144	Target Neighborhood Hits	244	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.069197 (rank : 96)
Query Neighborhood Hits	144	Target Neighborhood Hits	306	Shared Neighborhood Hits	53
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.070199 (rank : 94)
Query Neighborhood Hits	144	Target Neighborhood Hits	592	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

EFS_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.070788 (rank : 90)
Query Neighborhood Hits	144	Target Neighborhood Hits	348	Shared Neighborhood Hits	51
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.066287 (rank : 101)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	54
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

GRAP2_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.058936 (rank : 125)
Query Neighborhood Hits	144	Target Neighborhood Hits	304	Shared Neighborhood Hits	52
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.061881 (rank : 119)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	52
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.063143 (rank : 114)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	56
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.065047 (rank : 106)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.064551 (rank : 109)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	53
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GSCR1_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.056806 (rank : 132)
Query Neighborhood Hits	144	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HCLS1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.078911 (rank : 73)
Query Neighborhood Hits	144	Target Neighborhood Hits	358	Shared Neighborhood Hits	49
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.081914 (rank : 64)
Query Neighborhood Hits	144	Target Neighborhood Hits	329	Shared Neighborhood Hits	57
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.069593 (rank : 95)
Query Neighborhood Hits	144	Target Neighborhood Hits	1173	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.065327 (rank : 105)
Query Neighborhood Hits	144	Target Neighborhood Hits	1371	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MUC7_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.063870 (rank : 113)
Query Neighborhood Hits	144	Target Neighborhood Hits	538	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCF1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.071803 (rank : 87)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.070287 (rank : 93)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	41
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.078949 (rank : 72)
Query Neighborhood Hits	144	Target Neighborhood Hits	161	Shared Neighborhood Hits	40
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.080583 (rank : 66)
Query Neighborhood Hits	144	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.070776 (rank : 91)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.071375 (rank : 89)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	58
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBU_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.079937 (rank : 69)
Query Neighborhood Hits	144	Target Neighborhood Hits	420	Shared Neighborhood Hits	56
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NPHP1_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.050027 (rank : 158)
Query Neighborhood Hits	144	Target Neighborhood Hits	267	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NUMBL_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.058088 (rank : 128)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

NUMBL_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.065784 (rank : 104)
Query Neighborhood Hits	144	Target Neighborhood Hits	147	Shared Neighborhood Hits	10
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

NUMB_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.052371 (rank : 149)
Query Neighborhood Hits	144	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

NUMB_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.053315 (rank : 143)
Query Neighborhood Hits	144	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

PEX13_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.054013 (rank : 138)
Query Neighborhood Hits	144	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PRP2_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.060034 (rank : 123)
Query Neighborhood Hits	144	Target Neighborhood Hits	347	Shared Neighborhood Hits	23
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRPE_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.061791 (rank : 120)
Query Neighborhood Hits	144	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P02811	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide P-E (IB-9).

SH3G1_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.087114 (rank : 55)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.084085 (rank : 60)
Query Neighborhood Hits	144	Target Neighborhood Hits	291	Shared Neighborhood Hits	47
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.088205 (rank : 53)
Query Neighborhood Hits	144	Target Neighborhood Hits	324	Shared Neighborhood Hits	48
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.085207 (rank : 59)
Query Neighborhood Hits	144	Target Neighborhood Hits	319	Shared Neighborhood Hits	49
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.087726 (rank : 54)
Query Neighborhood Hits	144	Target Neighborhood Hits	222	Shared Neighborhood Hits	48
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.091184 (rank : 48)
Query Neighborhood Hits	144	Target Neighborhood Hits	236	Shared Neighborhood Hits	50
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SNX9_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.060669 (rank : 121)
Query Neighborhood Hits	144	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SRRM1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.055159 (rank : 136)
Query Neighborhood Hits	144	Target Neighborhood Hits	690	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.062428 (rank : 118)
Query Neighborhood Hits	144	Target Neighborhood Hits	966	Shared Neighborhood Hits	41
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.050210 (rank : 157)
Query Neighborhood Hits	144	Target Neighborhood Hits	1470	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

STAC3_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.058110 (rank : 127)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	42
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.057926 (rank : 130)
Query Neighborhood Hits	144	Target Neighborhood Hits	232	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.066417 (rank : 100)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	50
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.067150 (rank : 99)
Query Neighborhood Hits	144	Target Neighborhood Hits	273	Shared Neighborhood Hits	51
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.064004 (rank : 111)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	48
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.066263 (rank : 102)
Query Neighborhood Hits	144	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STS1_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.085491 (rank : 57)
Query Neighborhood Hits	144	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.082400 (rank : 63)
Query Neighborhood Hits	144	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SYN1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.055741 (rank : 134)
Query Neighborhood Hits	144	Target Neighborhood Hits	419	Shared Neighborhood Hits	24
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

VAV2_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.063058 (rank : 115)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	58
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.062810 (rank : 116)
Query Neighborhood Hits	144	Target Neighborhood Hits	456	Shared Neighborhood Hits	58
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.052281 (rank : 151)
Query Neighborhood Hits	144	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.052637 (rank : 147)
Query Neighborhood Hits	144	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.066072 (rank : 103)
Query Neighborhood Hits	144	Target Neighborhood Hits	452	Shared Neighborhood Hits	59
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

WASIP_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.055505 (rank : 135)
Query Neighborhood Hits	144	Target Neighborhood Hits	458	Shared Neighborhood Hits	27
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASL_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.053229 (rank : 144)
Query Neighborhood Hits	144	Target Neighborhood Hits	339	Shared Neighborhood Hits	17
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

Hits sorted by NC score

JIP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	144	Target Neighborhood Hits	144	Shared Neighborhood Hits	144
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_HUMAN
NC score	0.941773 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	99
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP1_HUMAN
NC score	0.845016 (rank : 3)	θ value	1.26366e-94 (rank : 3)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
NC score	0.844062 (rank : 4)	θ value	2.81514e-94 (rank : 4)
Query Neighborhood Hits	144	Target Neighborhood Hits	259	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

VINEX_MOUSE
NC score	0.255131 (rank : 5)	θ value	0.00020696 (rank : 6)
Query Neighborhood Hits	144	Target Neighborhood Hits	286	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.254088 (rank : 6)	θ value	0.000270298 (rank : 7)
Query Neighborhood Hits	144	Target Neighborhood Hits	270	Shared Neighborhood Hits	63
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SRBS1_HUMAN
NC score	0.241616 (rank : 7)	θ value	0.000461057 (rank : 8)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.237662 (rank : 8)	θ value	0.000602161 (rank : 9)
Query Neighborhood Hits	144	Target Neighborhood Hits	409	Shared Neighborhood Hits	67
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STS2_HUMAN
NC score	0.198983 (rank : 9)	θ value	0.00665767 (rank : 14)
Query Neighborhood Hits	144	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

LASP1_HUMAN
NC score	0.172942 (rank : 10)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	144	Target Neighborhood Hits	293	Shared Neighborhood Hits	59
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.172529 (rank : 11)	θ value	0.0330416 (rank : 23)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	59
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ARHG5_HUMAN
NC score	0.171759 (rank : 12)	θ value	0.00390308 (rank : 13)
Query Neighborhood Hits	144	Target Neighborhood Hits	172	Shared Neighborhood Hits	49
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PPIP1_HUMAN
NC score	0.169223 (rank : 13)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	60
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.157357 (rank : 14)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	144	Target Neighborhood Hits	377	Shared Neighborhood Hits	60
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CD2AP_HUMAN
NC score	0.156517 (rank : 15)	θ value	0.365318 (rank : 46)
Query Neighborhood Hits	144	Target Neighborhood Hits	315	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NCF2_HUMAN
NC score	0.144471 (rank : 16)	θ value	2.36792 (rank : 86)
Query Neighborhood Hits	144	Target Neighborhood Hits	229	Shared Neighborhood Hits	53
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

DNMBP_HUMAN
NC score	0.140097 (rank : 17)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	144	Target Neighborhood Hits	413	Shared Neighborhood Hits	64
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NEBL_HUMAN
NC score	0.136812 (rank : 18)	θ value	0.279714 (rank : 42)
Query Neighborhood Hits	144	Target Neighborhood Hits	457	Shared Neighborhood Hits	63
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SNX18_MOUSE
NC score	0.136292 (rank : 19)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	54
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SH3K1_MOUSE
NC score	0.134219 (rank : 20)	θ value	0.62314 (rank : 57)
Query Neighborhood Hits	144	Target Neighborhood Hits	332	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SNX18_HUMAN
NC score	0.133603 (rank : 21)	θ value	0.0961366 (rank : 33)
Query Neighborhood Hits	144	Target Neighborhood Hits	207	Shared Neighborhood Hits	54
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHGG_MOUSE
NC score	0.131386 (rank : 22)	θ value	0.00869519 (rank : 15)
Query Neighborhood Hits	144	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_MOUSE
NC score	0.130191 (rank : 23)	θ value	0.21417 (rank : 38)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

OSTF1_HUMAN
NC score	0.124846 (rank : 24)	θ value	0.279714 (rank : 43)
Query Neighborhood Hits	144	Target Neighborhood Hits	466	Shared Neighborhood Hits	59
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3K1_HUMAN
NC score	0.124814 (rank : 25)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	144	Target Neighborhood Hits	341	Shared Neighborhood Hits	60
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

OSTF1_MOUSE
NC score	0.117381 (rank : 26)	θ value	0.47712 (rank : 50)
Query Neighborhood Hits	144	Target Neighborhood Hits	467	Shared Neighborhood Hits	59
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NGEF_MOUSE
NC score	0.113309 (rank : 27)	θ value	0.21417 (rank : 39)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PACN1_MOUSE
NC score	0.112844 (rank : 28)	θ value	1.38821 (rank : 72)
Query Neighborhood Hits	144	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

STAC_MOUSE
NC score	0.112682 (rank : 29)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	144	Target Neighborhood Hits	268	Shared Neighborhood Hits	50
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PACN1_HUMAN
NC score	0.112508 (rank : 30)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	144	Target Neighborhood Hits	320	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

NGEF_HUMAN
NC score	0.111398 (rank : 31)	θ value	0.0961366 (rank : 32)
Query Neighborhood Hits	144	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

CD2AP_MOUSE
NC score	0.109888 (rank : 32)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	144	Target Neighborhood Hits	336	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PACN2_MOUSE
NC score	0.109608 (rank : 33)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	144	Target Neighborhood Hits	382	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ARH_MOUSE
NC score	0.109147 (rank : 34)	θ value	1.81305 (rank : 74)
Query Neighborhood Hits	144	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

FUT8_HUMAN
NC score	0.107601 (rank : 35)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	144	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

SPN90_MOUSE
NC score	0.107379 (rank : 36)	θ value	0.125558 (rank : 34)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

PACN3_HUMAN
NC score	0.106762 (rank : 37)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	144	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
NC score	0.105563 (rank : 38)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	144	Target Neighborhood Hits	380	Shared Neighborhood Hits	53
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN2_HUMAN
NC score	0.103810 (rank : 39)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	144	Target Neighborhood Hits	339	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

DDEF2_HUMAN
NC score	0.103465 (rank : 40)	θ value	0.0113563 (rank : 17)
Query Neighborhood Hits	144	Target Neighborhood Hits	599	Shared Neighborhood Hits	64
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.101724 (rank : 41)	θ value	0.0330416 (rank : 21)
Query Neighborhood Hits	144	Target Neighborhood Hits	625	Shared Neighborhood Hits	67
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FUT8_MOUSE
NC score	0.099754 (rank : 42)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	144	Target Neighborhood Hits	115	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

STAC_HUMAN
NC score	0.099500 (rank : 43)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	144	Target Neighborhood Hits	276	Shared Neighborhood Hits	52
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_MOUSE
NC score	0.099478 (rank : 44)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.097460 (rank : 45)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	144	Target Neighborhood Hits	347	Shared Neighborhood Hits	57
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DOCK1_HUMAN
NC score	0.096034 (rank : 46)	θ value	0.0252991 (rank : 19)
Query Neighborhood Hits	144	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SPN90_HUMAN
NC score	0.092885 (rank : 47)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SH3G3_MOUSE
NC score	0.091184 (rank : 48)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	144	Target Neighborhood Hits	236	Shared Neighborhood Hits	50
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ARHG6_HUMAN
NC score	0.090477 (rank : 49)	θ value	1.81305 (rank : 73)
Query Neighborhood Hits	144	Target Neighborhood Hits	376	Shared Neighborhood Hits	56
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SRC8_MOUSE
NC score	0.089743 (rank : 50)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	144	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ANKS1_MOUSE
NC score	0.089174 (rank : 51)	θ value	0.00175202 (rank : 11)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

SRC8_HUMAN
NC score	0.089162 (rank : 52)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	144	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SH3G2_HUMAN
NC score	0.088205 (rank : 53)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	144	Target Neighborhood Hits	324	Shared Neighborhood Hits	48
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
NC score	0.087726 (rank : 54)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	144	Target Neighborhood Hits	222	Shared Neighborhood Hits	48
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_HUMAN
NC score	0.087114 (rank : 55)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ABI2_HUMAN
NC score	0.086231 (rank : 56)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	144	Target Neighborhood Hits	350	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

STS1_HUMAN
NC score	0.085491 (rank : 57)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	144	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

PAF49_MOUSE
NC score	0.085303 (rank : 58)	θ value	0.0252991 (rank : 20)
Query Neighborhood Hits	144	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q76KJ5, Q8K0Y9	Gene names	Cd3eap, Ase1, Paf49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein).

SH3G2_MOUSE
NC score	0.085207 (rank : 59)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	144	Target Neighborhood Hits	319	Shared Neighborhood Hits	49
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G1_MOUSE
NC score	0.084085 (rank : 60)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	144	Target Neighborhood Hits	291	Shared Neighborhood Hits	47
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ANKS1_HUMAN
NC score	0.083774 (rank : 61)	θ value	0.00175202 (rank : 10)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	21
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ABI2_MOUSE
NC score	0.082829 (rank : 62)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	144	Target Neighborhood Hits	266	Shared Neighborhood Hits	53
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

STS1_MOUSE
NC score	0.082400 (rank : 63)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	144	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

HCLS1_MOUSE
NC score	0.081914 (rank : 64)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	144	Target Neighborhood Hits	329	Shared Neighborhood Hits	57
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SNX9_HUMAN
NC score	0.080704 (rank : 65)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	144	Target Neighborhood Hits	148	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

NCF4_MOUSE
NC score	0.080583 (rank : 66)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	144	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI1_MOUSE
NC score	0.080418 (rank : 67)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	144	Target Neighborhood Hits	246	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ARHG6_MOUSE
NC score	0.080257 (rank : 68)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

NEBU_HUMAN
NC score	0.079937 (rank : 69)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	144	Target Neighborhood Hits	420	Shared Neighborhood Hits	56
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CRK_MOUSE
NC score	0.079136 (rank : 70)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	144	Target Neighborhood Hits	314	Shared Neighborhood Hits	55
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ARH_HUMAN
NC score	0.078971 (rank : 71)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	144	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

NCF4_HUMAN
NC score	0.078949 (rank : 72)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	144	Target Neighborhood Hits	161	Shared Neighborhood Hits	40
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

HCLS1_HUMAN
NC score	0.078911 (rank : 73)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	144	Target Neighborhood Hits	358	Shared Neighborhood Hits	49
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI3_HUMAN
NC score	0.078673 (rank : 74)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

GRAP_MOUSE
NC score	0.077661 (rank : 75)	θ value	1.81305 (rank : 77)
Query Neighborhood Hits	144	Target Neighborhood Hits	309	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ARHGF_HUMAN
NC score	0.077115 (rank : 76)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	144	Target Neighborhood Hits	214	Shared Neighborhood Hits	25
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

CAPON_HUMAN
NC score	0.076981 (rank : 77)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	144	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CRK_HUMAN
NC score	0.076750 (rank : 78)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	144	Target Neighborhood Hits	308	Shared Neighborhood Hits	55
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ITSN1_HUMAN
NC score	0.076415 (rank : 79)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	144	Target Neighborhood Hits	1757	Shared Neighborhood Hits	75
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.076064 (rank : 80)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	144	Target Neighborhood Hits	1669	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ABI1_HUMAN
NC score	0.073615 (rank : 81)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	144	Target Neighborhood Hits	257	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

VAV_MOUSE
NC score	0.073447 (rank : 82)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	144	Target Neighborhood Hits	430	Shared Neighborhood Hits	60
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CAPON_MOUSE
NC score	0.073277 (rank : 83)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	144	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

ARHGG_HUMAN
NC score	0.073027 (rank : 84)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	144	Target Neighborhood Hits	129	Shared Neighborhood Hits	26
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

P85A_MOUSE
NC score	0.072066 (rank : 85)	θ value	0.813845 (rank : 59)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	43
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DP13A_MOUSE
NC score	0.071858 (rank : 86)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	144	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

NCF1_HUMAN
NC score	0.071803 (rank : 87)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

DP13A_HUMAN
NC score	0.071679 (rank : 88)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	144	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

NCK2_HUMAN
NC score	0.071375 (rank : 89)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	58
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

EFS_HUMAN
NC score	0.070788 (rank : 90)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	144	Target Neighborhood Hits	348	Shared Neighborhood Hits	51
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NCK1_HUMAN
NC score	0.070776 (rank : 91)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ABI3_MOUSE
NC score	0.070619 (rank : 92)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NCF1_MOUSE
NC score	0.070287 (rank : 93)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	41
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

DDEF1_MOUSE
NC score	0.070199 (rank : 94)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	144	Target Neighborhood Hits	592	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ITSN2_HUMAN
NC score	0.069593 (rank : 95)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	144	Target Neighborhood Hits	1173	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

DBNL_MOUSE
NC score	0.069197 (rank : 96)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	144	Target Neighborhood Hits	306	Shared Neighborhood Hits	53
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

BSN_HUMAN
NC score	0.067876 (rank : 97)	θ value	0.365318 (rank : 45)
Query Neighborhood Hits	144	Target Neighborhood Hits	1537	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

DBNL_HUMAN
NC score	0.067478 (rank : 98)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	144	Target Neighborhood Hits	244	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

STAM1_MOUSE
NC score	0.067150 (rank : 99)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	144	Target Neighborhood Hits	273	Shared Neighborhood Hits	51
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.066417 (rank : 100)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	50
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

EFS_MOUSE
NC score	0.066287 (rank : 101)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	54
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

STAM2_MOUSE
NC score	0.066263 (rank : 102)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	144	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VAV_HUMAN
NC score	0.066072 (rank : 103)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	144	Target Neighborhood Hits	452	Shared Neighborhood Hits	59
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NUMBL_MOUSE
NC score	0.065784 (rank : 104)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	144	Target Neighborhood Hits	147	Shared Neighborhood Hits	10
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

ITSN2_MOUSE
NC score	0.065327 (rank : 105)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	144	Target Neighborhood Hits	1371	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

GRB2_HUMAN
NC score	0.065047 (rank : 106)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

BAZ2A_MOUSE
NC score	0.064829 (rank : 107)	θ value	0.00020696 (rank : 5)
Query Neighborhood Hits	144	Target Neighborhood Hits	744	Shared Neighborhood Hits	28
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

APBA1_HUMAN
NC score	0.064602 (rank : 108)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	144	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

GRB2_MOUSE
NC score	0.064551 (rank : 109)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	53
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

CRKL_HUMAN
NC score	0.064280 (rank : 110)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	144	Target Neighborhood Hits	313	Shared Neighborhood Hits	51
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAM2_HUMAN
NC score	0.064004 (rank : 111)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	48
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CRKL_MOUSE
NC score	0.063965 (rank : 112)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	51
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

MUC7_HUMAN
NC score	0.063870 (rank : 113)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	144	Target Neighborhood Hits	538	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

GRAP_HUMAN
NC score	0.063143 (rank : 114)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	56
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

VAV2_HUMAN
NC score	0.063058 (rank : 115)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	58
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.062810 (rank : 116)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	144	Target Neighborhood Hits	456	Shared Neighborhood Hits	58
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

P85A_HUMAN
NC score	0.062437 (rank : 117)	θ value	2.36792 (rank : 88)
Query Neighborhood Hits	144	Target Neighborhood Hits	479	Shared Neighborhood Hits	42
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRRM1_MOUSE
NC score	0.062428 (rank : 118)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	144	Target Neighborhood Hits	966	Shared Neighborhood Hits	41
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

GRAP2_MOUSE
NC score	0.061881 (rank : 119)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	52
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PRPE_HUMAN
NC score	0.061791 (rank : 120)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	144	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P02811	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide P-E (IB-9).

SNX9_MOUSE
NC score	0.060669 (rank : 121)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	144	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

BSN_MOUSE
NC score	0.060168 (rank : 122)	θ value	0.163984 (rank : 37)
Query Neighborhood Hits	144	Target Neighborhood Hits	2057	Shared Neighborhood Hits	48
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PRP2_MOUSE
NC score	0.060034 (rank : 123)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	144	Target Neighborhood Hits	347	Shared Neighborhood Hits	23
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

LEO1_MOUSE
NC score	0.059557 (rank : 124)	θ value	0.0431538 (rank : 25)
Query Neighborhood Hits	144	Target Neighborhood Hits	946	Shared Neighborhood Hits	17
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

GRAP2_HUMAN
NC score	0.058936 (rank : 125)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	144	Target Neighborhood Hits	304	Shared Neighborhood Hits	52
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

DP13B_HUMAN
NC score	0.058811 (rank : 126)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	144	Target Neighborhood Hits	58	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

STAC3_HUMAN
NC score	0.058110 (rank : 127)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	42
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NUMBL_HUMAN
NC score	0.058088 (rank : 128)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

CN104_HUMAN
NC score	0.057942 (rank : 129)	θ value	1.81305 (rank : 75)
Query Neighborhood Hits	144	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NVR5, Q86TY8, Q969Z5	Gene names	C14orf104
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf104.

STAC3_MOUSE
NC score	0.057926 (rank : 130)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	144	Target Neighborhood Hits	232	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TB182_HUMAN
NC score	0.057414 (rank : 131)	θ value	0.47712 (rank : 51)
Query Neighborhood Hits	144	Target Neighborhood Hits	414	Shared Neighborhood Hits	18
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

GSCR1_HUMAN
NC score	0.056806 (rank : 132)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	144	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

RGS3_MOUSE
NC score	0.055877 (rank : 133)	θ value	0.279714 (rank : 44)
Query Neighborhood Hits	144	Target Neighborhood Hits	1621	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SYN1_HUMAN
NC score	0.055741 (rank : 134)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	144	Target Neighborhood Hits	419	Shared Neighborhood Hits	24
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

WASIP_HUMAN
NC score	0.055505 (rank : 135)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	144	Target Neighborhood Hits	458	Shared Neighborhood Hits	27
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

SRRM1_HUMAN
NC score	0.055159 (rank : 136)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	144	Target Neighborhood Hits	690	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

MYO1F_MOUSE
NC score	0.055156 (rank : 137)	θ value	0.365318 (rank : 47)
Query Neighborhood Hits	144	Target Neighborhood Hits	262	Shared Neighborhood Hits	53
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PEX13_MOUSE
NC score	0.054013 (rank : 138)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	144	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

BRCA1_MOUSE
NC score	0.053979 (rank : 139)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	144	Target Neighborhood Hits	436	Shared Neighborhood Hits	7
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

DP13B_MOUSE
NC score	0.053918 (rank : 140)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	144	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

MYO1F_HUMAN
NC score	0.053851 (rank : 141)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	144	Target Neighborhood Hits	275	Shared Neighborhood Hits	54
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

APBA2_MOUSE
NC score	0.053783 (rank : 142)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	144	Target Neighborhood Hits	219	Shared Neighborhood Hits	16
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

NUMB_MOUSE
NC score	0.053315 (rank : 143)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	144	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

WASL_MOUSE
NC score	0.053229 (rank : 144)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	144	Target Neighborhood Hits	339	Shared Neighborhood Hits	17
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

SHC1_MOUSE
NC score	0.053071 (rank : 145)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	144	Target Neighborhood Hits	180	Shared Neighborhood Hits	20
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

CT032_HUMAN
NC score	0.052730 (rank : 146)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	144	Target Neighborhood Hits	235	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

VAV3_MOUSE
NC score	0.052637 (rank : 147)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	144	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG4_HUMAN
NC score	0.052580 (rank : 148)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	144	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NUMB_HUMAN
NC score	0.052371 (rank : 149)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	144	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

BCAR1_HUMAN
NC score	0.052283 (rank : 150)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	144	Target Neighborhood Hits	554	Shared Neighborhood Hits	58
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

VAV3_HUMAN
NC score	0.052281 (rank : 151)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	144	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

LEO1_HUMAN
NC score	0.052259 (rank : 152)	θ value	0.0193708 (rank : 18)
Query Neighborhood Hits	144	Target Neighborhood Hits	958	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

APBA2_HUMAN
NC score	0.052132 (rank : 153)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	144	Target Neighborhood Hits	220	Shared Neighborhood Hits	11
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

BIN1_HUMAN
NC score	0.051268 (rank : 154)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	144	Target Neighborhood Hits	335	Shared Neighborhood Hits	41
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BCAR1_MOUSE
NC score	0.051031 (rank : 155)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	57
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SHC1_HUMAN
NC score	0.050831 (rank : 156)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	144	Target Neighborhood Hits	170	Shared Neighborhood Hits	17
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SRRM2_MOUSE
NC score	0.050210 (rank : 157)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	144	Target Neighborhood Hits	1470	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

NPHP1_MOUSE
NC score	0.050027 (rank : 158)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	144	Target Neighborhood Hits	267	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

TNR11_HUMAN
NC score	0.049906 (rank : 159)	θ value	0.00869519 (rank : 16)
Query Neighborhood Hits	144	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6Q6	Gene names	TNFRSF11A, RANK
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen).

PDXL2_MOUSE
NC score	0.045611 (rank : 160)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	144	Target Neighborhood Hits	213	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

APXL_HUMAN
NC score	0.045519 (rank : 161)	θ value	0.163984 (rank : 36)
Query Neighborhood Hits	144	Target Neighborhood Hits	553	Shared Neighborhood Hits	15
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

P85B_HUMAN
NC score	0.045110 (rank : 162)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	144	Target Neighborhood Hits	543	Shared Neighborhood Hits	33
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ASPP1_MOUSE
NC score	0.042424 (rank : 163)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	144	Target Neighborhood Hits	1244	Shared Neighborhood Hits	66
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

P85B_MOUSE
NC score	0.042193 (rank : 164)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	144	Target Neighborhood Hits	519	Shared Neighborhood Hits	29
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SAPS1_HUMAN
NC score	0.039447 (rank : 165)	θ value	0.62314 (rank : 56)
Query Neighborhood Hits	144	Target Neighborhood Hits	704	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

NASP_HUMAN
NC score	0.037763 (rank : 166)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	144	Target Neighborhood Hits	709	Shared Neighborhood Hits	19
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

YTHD1_HUMAN
NC score	0.036972 (rank : 167)	θ value	0.813845 (rank : 61)
Query Neighborhood Hits	144	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYJ9, Q8N3G5, Q8TBT1, Q96AN4, Q96S57, Q9BTI7, Q9NX79	Gene names	YTHDF1, C20orf21
Domain Architecture
Description	YTH domain family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1).

DCC_MOUSE
NC score	0.036278 (rank : 168)	θ value	0.00298849 (rank : 12)
Query Neighborhood Hits	144	Target Neighborhood Hits	896	Shared Neighborhood Hits	18
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

ES8L2_MOUSE
NC score	0.035766 (rank : 169)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	144	Target Neighborhood Hits	169	Shared Neighborhood Hits	38
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SON_HUMAN
NC score	0.035141 (rank : 170)	θ value	0.0330416 (rank : 24)
Query Neighborhood Hits	144	Target Neighborhood Hits	1568	Shared Neighborhood Hits	31
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

HTSF1_HUMAN
NC score	0.032676 (rank : 171)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	144	Target Neighborhood Hits	408	Shared Neighborhood Hits	11
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

SIG12_MOUSE
NC score	0.031724 (rank : 172)	θ value	0.365318 (rank : 48)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

CABIN_HUMAN
NC score	0.030289 (rank : 173)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	144	Target Neighborhood Hits	490	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

NBEA_MOUSE
NC score	0.029504 (rank : 174)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

CSF1_HUMAN
NC score	0.029088 (rank : 175)	θ value	1.81305 (rank : 76)
Query Neighborhood Hits	144	Target Neighborhood Hits	258	Shared Neighborhood Hits	12
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

CO039_MOUSE
NC score	0.029069 (rank : 176)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	144	Target Neighborhood Hits	445	Shared Neighborhood Hits	13
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

OXR1_MOUSE
NC score	0.028452 (rank : 177)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	144	Target Neighborhood Hits	516	Shared Neighborhood Hits	13
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

VINC_HUMAN
NC score	0.028238 (rank : 178)	θ value	0.813845 (rank : 60)
Query Neighborhood Hits	144	Target Neighborhood Hits	145	Shared Neighborhood Hits	6
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

MAP1A_HUMAN
NC score	0.024569 (rank : 179)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	144	Target Neighborhood Hits	1626	Shared Neighborhood Hits	45
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

SPEG_HUMAN
NC score	0.023732 (rank : 180)	θ value	1.81305 (rank : 83)
Query Neighborhood Hits	144	Target Neighborhood Hits	1762	Shared Neighborhood Hits	38
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

NSBP1_MOUSE
NC score	0.022517 (rank : 181)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	144	Target Neighborhood Hits	681	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

ANKS3_MOUSE
NC score	0.022069 (rank : 182)	θ value	1.38821 (rank : 67)
Query Neighborhood Hits	144	Target Neighborhood Hits	355	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ACK1_MOUSE
NC score	0.021618 (rank : 183)	θ value	0.279714 (rank : 41)
Query Neighborhood Hits	144	Target Neighborhood Hits	1080	Shared Neighborhood Hits	41
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

MYST3_MOUSE
NC score	0.021380 (rank : 184)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	144	Target Neighborhood Hits	688	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

ACK1_HUMAN
NC score	0.021043 (rank : 185)	θ value	0.279714 (rank : 40)
Query Neighborhood Hits	144	Target Neighborhood Hits	1140	Shared Neighborhood Hits	34
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

TCAL5_HUMAN
NC score	0.020809 (rank : 186)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	144	Target Neighborhood Hits	806	Shared Neighborhood Hits	17
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

CAC1B_MOUSE
NC score	0.020630 (rank : 187)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	144	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

ZAR1_MOUSE
NC score	0.019774 (rank : 188)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	144	Target Neighborhood Hits	254	Shared Neighborhood Hits	9
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

DMN_HUMAN
NC score	0.019408 (rank : 189)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	144	Target Neighborhood Hits	690	Shared Neighborhood Hits	20
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

SPEG_MOUSE
NC score	0.019133 (rank : 190)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	144	Target Neighborhood Hits	1959	Shared Neighborhood Hits	40
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

POF1B_HUMAN
NC score	0.018845 (rank : 191)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	144	Target Neighborhood Hits	494	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

PI51C_HUMAN
NC score	0.018309 (rank : 192)	θ value	1.81305 (rank : 82)
Query Neighborhood Hits	144	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

TXK_MOUSE
NC score	0.018106 (rank : 193)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	54
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TBX2_HUMAN
NC score	0.017445 (rank : 194)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	144	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

KCNQ5_HUMAN
NC score	0.017011 (rank : 195)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	144	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

US6NL_HUMAN
NC score	0.016361 (rank : 196)	θ value	2.36792 (rank : 89)
Query Neighborhood Hits	144	Target Neighborhood Hits	201	Shared Neighborhood Hits	6
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

NF2L1_MOUSE
NC score	0.016018 (rank : 197)	θ value	2.36792 (rank : 87)
Query Neighborhood Hits	144	Target Neighborhood Hits	185	Shared Neighborhood Hits	3
SwissProt Accessions	Q61985, O70234	Gene names	Nfe2l1, Nrf1
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1).

FRS3_MOUSE
NC score	0.015820 (rank : 198)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	144	Target Neighborhood Hits	168	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

POF1B_MOUSE
NC score	0.015439 (rank : 199)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	144	Target Neighborhood Hits	530	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

TAU_MOUSE
NC score	0.015403 (rank : 200)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	144	Target Neighborhood Hits	502	Shared Neighborhood Hits	16
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

LN28B_HUMAN
NC score	0.014851 (rank : 201)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	144	Target Neighborhood Hits	66	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZN17	Gene names	LIN28B, CSDD2
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

CAC1E_MOUSE
NC score	0.014705 (rank : 202)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	144	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

UBXD1_HUMAN
NC score	0.014582 (rank : 203)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	144	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZV1, Q96AH1, Q96IK9, Q9BZV0	Gene names	UBXD1, UBXDC2
Domain Architecture
Description	UBX domain-containing protein 1.

LAX1_HUMAN
NC score	0.014054 (rank : 204)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	144	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWV1, Q6NSZ6, Q9NXB4	Gene names	LAX1, LAX
Domain Architecture	No domain graphic available
Description	Lymphocyte transmembrane adapter 1 (Membrane-associated adapter protein LAX) (Linker for activation of X cells).

OBSCN_HUMAN
NC score	0.012596 (rank : 205)	θ value	1.81305 (rank : 81)
Query Neighborhood Hits	144	Target Neighborhood Hits	1931	Shared Neighborhood Hits	33
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

GAK_HUMAN
NC score	0.012330 (rank : 206)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	144	Target Neighborhood Hits	1028	Shared Neighborhood Hits	18
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ZN516_MOUSE
NC score	0.012012 (rank : 207)	θ value	0.125558 (rank : 35)
Query Neighborhood Hits	144	Target Neighborhood Hits	1197	Shared Neighborhood Hits	23
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

UBQL3_MOUSE
NC score	0.011516 (rank : 208)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	144	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C5U9	Gene names	Ubqln3
Domain Architecture
Description	Ubiquilin-3.

KIF4A_MOUSE
NC score	0.011046 (rank : 209)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	144	Target Neighborhood Hits	1033	Shared Neighborhood Hits	22
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MAGB6_HUMAN
NC score	0.009754 (rank : 210)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	144	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

NEK9_MOUSE
NC score	0.009609 (rank : 211)	θ value	0.0961366 (rank : 31)
Query Neighborhood Hits	144	Target Neighborhood Hits	890	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

FREM3_MOUSE
NC score	0.008504 (rank : 212)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	144	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

JHD3B_HUMAN
NC score	0.007629 (rank : 213)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	144	Target Neighborhood Hits	128	Shared Neighborhood Hits	8
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

LATS2_HUMAN
NC score	0.007461 (rank : 214)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	144	Target Neighborhood Hits	884	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

KI13A_HUMAN
NC score	0.007019 (rank : 215)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	144	Target Neighborhood Hits	359	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H1H9, Q9H1H8	Gene names	KIF13A, RBKIN
Domain Architecture
Description	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN).

LUZP1_MOUSE
NC score	0.006930 (rank : 216)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	144	Target Neighborhood Hits	940	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MEFV_HUMAN
NC score	0.005984 (rank : 217)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	144	Target Neighborhood Hits	431	Shared Neighborhood Hits	8
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LATS2_MOUSE
NC score	0.005378 (rank : 218)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	144	Target Neighborhood Hits	879	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

GP124_MOUSE
NC score	0.004897 (rank : 219)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	144	Target Neighborhood Hits	423	Shared Neighborhood Hits	4
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GLI2_HUMAN
NC score	0.004629 (rank : 220)	θ value	0.62314 (rank : 52)
Query Neighborhood Hits	144	Target Neighborhood Hits	971	Shared Neighborhood Hits	12
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

PTN22_MOUSE
NC score	0.002561 (rank : 221)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	144	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

EVI1_MOUSE
NC score	0.001243 (rank : 222)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	144	Target Neighborhood Hits	826	Shared Neighborhood Hits	7
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

5HT6R_HUMAN
NC score	-0.001560 (rank : 223)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	144	Target Neighborhood Hits	882	Shared Neighborhood Hits	2
SwissProt Accessions	P50406, Q13640	Gene names	HTR6
Domain Architecture
Description	5-hydroxytryptamine 6 receptor (5-HT-6) (Serotonin receptor 6).