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Network neighborhood for query Sequence : PI51C_HUMAN

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PI51C_HUMAN
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PI51A_HUMAN
θ value	0 (rank : 1)	NC score	0.982084 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

PI51A_MOUSE
θ value	0 (rank : 2)	NC score	0.983581 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	P70182, Q8K0D3, Q99L80	Gene names	Pip5k1a, Pip5k1b
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (Phosphatidylinositol-4-phosphate 5- kinase type I beta) (PI4P5KIbeta) (68 kDa type I phosphatidylinositol- 4-phosphate 5-kinase).

PI51C_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51C_MOUSE
θ value	0 (rank : 4)	NC score	0.989471 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51B_MOUSE
θ value	6.11349e-182 (rank : 5)	NC score	0.981046 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P70181, O70335, Q8JZY6	Gene names	Pip5k1b, Pip5k1a
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PIP5KIalpha).

PI51B_HUMAN
θ value	2.48782e-175 (rank : 6)	NC score	0.980909 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

PI52B_HUMAN
θ value	4.568e-36 (rank : 7)	NC score	0.819453 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P78356, Q5U0E8, Q8TBP2	Gene names	PIP5K2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52B_MOUSE
θ value	4.568e-36 (rank : 8)	NC score	0.819799 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q80XI4, Q8VHB2	Gene names	Pip5k2b
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52A_HUMAN
θ value	1.6247e-33 (rank : 9)	NC score	0.811583 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P48426, P53807, Q5VUX3	Gene names	PIP5K2A, PIP5K2
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KIII) (PtdIns(4)P-5-kinase C isoform).

PI52A_MOUSE
θ value	1.0531e-32 (rank : 10)	NC score	0.809647 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	O70172	Gene names	Pip5k2a
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha).

FYV1_MOUSE
θ value	1.38499e-08 (rank : 11)	NC score	0.325742 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	191	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
θ value	6.87365e-08 (rank : 12)	NC score	0.314778 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

IWS1_HUMAN
θ value	0.0148317 (rank : 13)	NC score	0.053318 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	1241	Shared Neighborhood Hits	51
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ACK1_HUMAN
θ value	0.0431538 (rank : 14)	NC score	0.007677 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	1140	Shared Neighborhood Hits	20
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

TCOF_HUMAN
θ value	0.0431538 (rank : 15)	NC score	0.054002 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	543	Shared Neighborhood Hits	30
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

RGS3_MOUSE
θ value	0.0563607 (rank : 16)	NC score	0.030868 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	1621	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CN155_HUMAN
θ value	0.0961366 (rank : 17)	NC score	0.049035 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	385	Shared Neighborhood Hits	24
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

RP1L1_HUMAN
θ value	0.0961366 (rank : 18)	NC score	0.038244 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	1072	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

BASP_HUMAN
θ value	0.163984 (rank : 19)	NC score	0.056976 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	321	Shared Neighborhood Hits	24
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

PALB2_MOUSE
θ value	0.365318 (rank : 20)	NC score	0.031995 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

NCOR2_MOUSE
θ value	0.47712 (rank : 21)	NC score	0.034191 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	790	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

RFFL_HUMAN
θ value	0.47712 (rank : 22)	NC score	0.027346 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	175	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFIP1_HUMAN
θ value	0.47712 (rank : 23)	NC score	0.049931 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

IWS1_MOUSE
θ value	0.62314 (rank : 24)	NC score	0.049151 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	1258	Shared Neighborhood Hits	54
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NCOR2_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.035812 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	870	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

MAGC1_HUMAN
θ value	0.813845 (rank : 26)	NC score	0.017496 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	431	Shared Neighborhood Hits	21
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MDN1_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.033551 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	662	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

TNNT2_MOUSE
θ value	0.813845 (rank : 28)	NC score	0.020355 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	395	Shared Neighborhood Hits	7
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

VCX1_HUMAN
θ value	0.813845 (rank : 29)	NC score	0.053068 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	129	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H320, Q9P0H3	Gene names	VCX, VCX1, VCX10R, VCXB1
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 1 (VCX-B1 protein) (Variably charged protein X-B1) (Variable charge protein on X with ten repeats) (VCX- 10r).

WNK2_HUMAN
θ value	0.813845 (rank : 30)	NC score	0.008871 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	1407	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ADDB_MOUSE
θ value	1.06291 (rank : 31)	NC score	0.031264 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	574	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

BASP_MOUSE
θ value	1.06291 (rank : 32)	NC score	0.047452 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	260	Shared Neighborhood Hits	23
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

DHX57_MOUSE
θ value	1.06291 (rank : 33)	NC score	0.010795 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

IASPP_MOUSE
θ value	1.06291 (rank : 34)	NC score	0.012794 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	1024	Shared Neighborhood Hits	25
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MINT_MOUSE
θ value	1.06291 (rank : 35)	NC score	0.024687 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	1514	Shared Neighborhood Hits	53
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NFM_HUMAN
θ value	1.06291 (rank : 36)	NC score	0.008977 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	1328	Shared Neighborhood Hits	38
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

TXLNB_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.019428 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	912	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

ANR41_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.013031 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

CAMKV_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.003764 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	1084	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CNGB1_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.017228 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	222	Shared Neighborhood Hits	14
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

LIPS_HUMAN
θ value	1.38821 (rank : 41)	NC score	0.028450 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

PHC2_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.017381 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	388	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

RBM19_MOUSE
θ value	1.38821 (rank : 43)	NC score	0.011827 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	296	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R3C6, Q8BHR0, Q9CW63	Gene names	Rbm19
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

RTN2_MOUSE
θ value	1.38821 (rank : 44)	NC score	0.022851 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

SMRC2_MOUSE
θ value	1.38821 (rank : 45)	NC score	0.021818 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	487	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

VCXC_HUMAN
θ value	1.38821 (rank : 46)	NC score	0.049311 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	139	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H321	Gene names	VCXC
Domain Architecture	No domain graphic available
Description	VCX-C protein (Variably charged protein X-C).

EDRF1_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.018947 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q6GQV7, Q80ZY3, Q8R3P5	Gene names	Edrf1
Domain Architecture	No domain graphic available
Description	Erythroid differentiation-related factor 1.

GRIN1_MOUSE
θ value	1.81305 (rank : 48)	NC score	0.027598 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	337	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HCN2_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.012573 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	369	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

JIP2_MOUSE
θ value	1.81305 (rank : 50)	NC score	0.018309 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

LRCH4_HUMAN
θ value	1.81305 (rank : 51)	NC score	0.006579 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	O75427, Q8WV85, Q96ID0	Gene names	LRCH4, LRN, LRRN4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4 (Leucine-rich neuronal protein).

NEUM_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.037139 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	149	Shared Neighborhood Hits	19
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

VCX3_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.051085 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NNX9, Q9P0H4	Gene names	VCX3A, VCX3, VCX8R, VCXA
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 3 (VCX-A protein) (Variably charged protein X-A) (Variable charge protein on X with eight repeats) (VCX- 8r).

BRD3_HUMAN
θ value	2.36792 (rank : 54)	NC score	0.012711 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	369	Shared Neighborhood Hits	12
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

HMGA1_HUMAN
θ value	2.36792 (rank : 55)	NC score	0.049329 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P17096, P10910, Q9UKB0	Gene names	HMGA1, HMGIY
Domain Architecture	No domain graphic available
Description	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein-R).

MAP2_HUMAN
θ value	2.36792 (rank : 56)	NC score	0.018896 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	348	Shared Neighborhood Hits	16
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

NCKX2_HUMAN
θ value	2.36792 (rank : 57)	NC score	0.016760 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UI40, Q9NTN5, Q9NZQ4	Gene names	SLC24A2, NCKX2
Domain Architecture
Description	Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2).

SRCA_MOUSE
θ value	2.36792 (rank : 58)	NC score	0.022318 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	212	Shared Neighborhood Hits	22
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

TGON2_HUMAN
θ value	2.36792 (rank : 59)	NC score	0.038344 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	1037	Shared Neighborhood Hits	54
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TTBK1_HUMAN
θ value	2.36792 (rank : 60)	NC score	0.007246 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	1058	Shared Neighborhood Hits	25
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

AMPH_HUMAN
θ value	3.0926 (rank : 61)	NC score	0.021834 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	455	Shared Neighborhood Hits	29
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

RTN4_MOUSE
θ value	3.0926 (rank : 62)	NC score	0.023977 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	341	Shared Neighborhood Hits	23
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SAPS1_HUMAN
θ value	3.0926 (rank : 63)	NC score	0.017012 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	704	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

TCOF_MOUSE
θ value	3.0926 (rank : 64)	NC score	0.039054 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	471	Shared Neighborhood Hits	31
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

ACK1_MOUSE
θ value	4.03905 (rank : 65)	NC score	0.004642 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	1080	Shared Neighborhood Hits	18
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

BIR1G_MOUSE
θ value	4.03905 (rank : 66)	NC score	0.015034 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	92	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

DDX21_MOUSE
θ value	4.03905 (rank : 67)	NC score	0.009309 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	350	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DNM3A_MOUSE
θ value	4.03905 (rank : 68)	NC score	0.013826 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

MAGB6_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.012050 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	184	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

MDC1_MOUSE
θ value	4.03905 (rank : 70)	NC score	0.030510 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	998	Shared Neighborhood Hits	55
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NFH_HUMAN
θ value	4.03905 (rank : 71)	NC score	0.012748 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	1242	Shared Neighborhood Hits	34
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NVL_HUMAN
θ value	4.03905 (rank : 72)	NC score	0.008034 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	6
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

RGP2_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.010950 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

TXND2_MOUSE
θ value	4.03905 (rank : 74)	NC score	0.026626 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	828	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

BCLF1_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.014683 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	298	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

BIR1E_MOUSE
θ value	5.27518 (rank : 76)	NC score	0.014569 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	5.27518 (rank : 77)	NC score	0.014592 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

COFA1_HUMAN
θ value	5.27518 (rank : 78)	NC score	0.008309 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	292	Shared Neighborhood Hits	14
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

FA8_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.015558 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	P00451	Gene names	F8, F8C
Domain Architecture
Description	Coagulation factor VIII precursor (Procoagulant component) (Antihemophilic factor) (AHF) [Contains: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain].

GNDS_HUMAN
θ value	5.27518 (rank : 80)	NC score	0.009612 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	201	Shared Neighborhood Hits	10
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

HMGA1_MOUSE
θ value	5.27518 (rank : 81)	NC score	0.035675 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P17095, Q91WV2, Q924L7, Q924L8	Gene names	Hmga1, Hmgi, Hmgiy
Domain Architecture	No domain graphic available
Description	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1).

NCKX1_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.019467 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	223	Shared Neighborhood Hits	15
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

SART3_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.007568 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	301	Shared Neighborhood Hits	4
SwissProt Accessions	Q15020, Q58F06, Q8IUS1, Q96J95	Gene names	SART3, KIAA0156, TIP110
Domain Architecture	No domain graphic available
Description	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (hSART-3) (Tat-interacting protein of 110 kDa) (Tip110).

TNNT2_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.014301 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

AIPL1_HUMAN
θ value	6.88961 (rank : 85)	NC score	0.009041 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN9, Q9H873, Q9NS10	Gene names	AIPL1
Domain Architecture
Description	Aryl-hydrocarbon-interacting protein-like 1.

CHD4_MOUSE
θ value	6.88961 (rank : 86)	NC score	0.006938 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	408	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CMTA2_MOUSE
θ value	6.88961 (rank : 87)	NC score	0.011349 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	216	Shared Neighborhood Hits	12
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

HEXB_MOUSE
θ value	6.88961 (rank : 88)	NC score	0.017708 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P20060	Gene names	Hexb
Domain Architecture
Description	Beta-hexosaminidase beta chain precursor (EC 3.2.1.52) (N-acetyl-beta- glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase B).

IC1_MOUSE
θ value	6.88961 (rank : 89)	NC score	0.004840 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	164	Shared Neighborhood Hits	9
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

MARCS_HUMAN
θ value	6.88961 (rank : 90)	NC score	0.022564 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	204	Shared Neighborhood Hits	17
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

MDC1_HUMAN
θ value	6.88961 (rank : 91)	NC score	0.025644 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	1446	Shared Neighborhood Hits	56
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MYST4_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.010477 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	671	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

NBN_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.013671 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	226	Shared Neighborhood Hits	14
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

RPGR1_MOUSE
θ value	6.88961 (rank : 94)	NC score	0.010538 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	713	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RYR1_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.008979 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	303	Shared Neighborhood Hits	12
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

ZN202_HUMAN
θ value	6.88961 (rank : 96)	NC score	-0.002908 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	756	Shared Neighborhood Hits	5
SwissProt Accessions	O95125, Q4JG21, Q9H1B9, Q9NSM4	Gene names	ZNF202
Domain Architecture
Description	Zinc finger protein 202.

ZN326_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.010098 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	7
SwissProt Accessions	O88291, Q8BSJ5, Q8K1X9, Q9CYG9	Gene names	Znf326, Zan75, Zfp326
Domain Architecture	No domain graphic available
Description	Zinc finger protein 326 (Zinc finger protein-associated with nuclear matrix of 75 kDa).

AP3B2_MOUSE
θ value	8.99809 (rank : 98)	NC score	0.010116 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	246	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

BRD3_MOUSE
θ value	8.99809 (rank : 99)	NC score	0.011619 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	402	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

CD2L1_HUMAN
θ value	8.99809 (rank : 100)	NC score	0.001429 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	1467	Shared Neighborhood Hits	24
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CHFR_HUMAN
θ value	8.99809 (rank : 101)	NC score	0.006681 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

DNM3A_HUMAN
θ value	8.99809 (rank : 102)	NC score	0.011908 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	104	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

MAGD1_HUMAN
θ value	8.99809 (rank : 103)	NC score	0.010494 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	130	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

NALP5_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.003517 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NKX28_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.000441 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	347	Shared Neighborhood Hits	2
SwissProt Accessions	O70584	Gene names	Nkx2-8, Nkx-2.9, Nkx2-9, Nkx2h
Domain Architecture
Description	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H) (Homeobox protein Nkx-2.9).

PP16A_MOUSE
θ value	8.99809 (rank : 106)	NC score	0.002953 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	318	Shared Neighborhood Hits	5
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

RP1L1_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.022615 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

SET1A_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.018952 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	690	Shared Neighborhood Hits	32
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

TJAP1_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.006927 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

Hits sorted by NC score

PI51C_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51C_MOUSE
NC score	0.989471 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51A_MOUSE
NC score	0.983581 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	P70182, Q8K0D3, Q99L80	Gene names	Pip5k1a, Pip5k1b
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (Phosphatidylinositol-4-phosphate 5- kinase type I beta) (PI4P5KIbeta) (68 kDa type I phosphatidylinositol- 4-phosphate 5-kinase).

PI51A_HUMAN
NC score	0.982084 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

PI51B_MOUSE
NC score	0.981046 (rank : 5)	θ value	6.11349e-182 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P70181, O70335, Q8JZY6	Gene names	Pip5k1b, Pip5k1a
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PIP5KIalpha).

PI51B_HUMAN
NC score	0.980909 (rank : 6)	θ value	2.48782e-175 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

PI52B_MOUSE
NC score	0.819799 (rank : 7)	θ value	4.568e-36 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q80XI4, Q8VHB2	Gene names	Pip5k2b
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52B_HUMAN
NC score	0.819453 (rank : 8)	θ value	4.568e-36 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P78356, Q5U0E8, Q8TBP2	Gene names	PIP5K2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52A_HUMAN
NC score	0.811583 (rank : 9)	θ value	1.6247e-33 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P48426, P53807, Q5VUX3	Gene names	PIP5K2A, PIP5K2
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KIII) (PtdIns(4)P-5-kinase C isoform).

PI52A_MOUSE
NC score	0.809647 (rank : 10)	θ value	1.0531e-32 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	O70172	Gene names	Pip5k2a
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha).

FYV1_MOUSE
NC score	0.325742 (rank : 11)	θ value	1.38499e-08 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	191	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.314778 (rank : 12)	θ value	6.87365e-08 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

BASP_HUMAN
NC score	0.056976 (rank : 13)	θ value	0.163984 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	321	Shared Neighborhood Hits	24
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

TCOF_HUMAN
NC score	0.054002 (rank : 14)	θ value	0.0431538 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	543	Shared Neighborhood Hits	30
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

IWS1_HUMAN
NC score	0.053318 (rank : 15)	θ value	0.0148317 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	1241	Shared Neighborhood Hits	51
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

VCX1_HUMAN
NC score	0.053068 (rank : 16)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	129	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H320, Q9P0H3	Gene names	VCX, VCX1, VCX10R, VCXB1
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 1 (VCX-B1 protein) (Variably charged protein X-B1) (Variable charge protein on X with ten repeats) (VCX- 10r).

VCX3_HUMAN
NC score	0.051085 (rank : 17)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NNX9, Q9P0H4	Gene names	VCX3A, VCX3, VCX8R, VCXA
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 3 (VCX-A protein) (Variably charged protein X-A) (Variable charge protein on X with eight repeats) (VCX- 8r).

RFIP1_HUMAN
NC score	0.049931 (rank : 18)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

HMGA1_HUMAN
NC score	0.049329 (rank : 19)	θ value	2.36792 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P17096, P10910, Q9UKB0	Gene names	HMGA1, HMGIY
Domain Architecture	No domain graphic available
Description	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein-R).

VCXC_HUMAN
NC score	0.049311 (rank : 20)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	139	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H321	Gene names	VCXC
Domain Architecture	No domain graphic available
Description	VCX-C protein (Variably charged protein X-C).

IWS1_MOUSE
NC score	0.049151 (rank : 21)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	1258	Shared Neighborhood Hits	54
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

CN155_HUMAN
NC score	0.049035 (rank : 22)	θ value	0.0961366 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	385	Shared Neighborhood Hits	24
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

BASP_MOUSE
NC score	0.047452 (rank : 23)	θ value	1.06291 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	260	Shared Neighborhood Hits	23
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

TCOF_MOUSE
NC score	0.039054 (rank : 24)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	471	Shared Neighborhood Hits	31
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TGON2_HUMAN
NC score	0.038344 (rank : 25)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	1037	Shared Neighborhood Hits	54
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

RP1L1_HUMAN
NC score	0.038244 (rank : 26)	θ value	0.0961366 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	1072	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

NEUM_MOUSE
NC score	0.037139 (rank : 27)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	149	Shared Neighborhood Hits	19
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

NCOR2_HUMAN
NC score	0.035812 (rank : 28)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	870	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

HMGA1_MOUSE
NC score	0.035675 (rank : 29)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P17095, Q91WV2, Q924L7, Q924L8	Gene names	Hmga1, Hmgi, Hmgiy
Domain Architecture	No domain graphic available
Description	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1).

NCOR2_MOUSE
NC score	0.034191 (rank : 30)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	790	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

MDN1_HUMAN
NC score	0.033551 (rank : 31)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	662	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

PALB2_MOUSE
NC score	0.031995 (rank : 32)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

ADDB_MOUSE
NC score	0.031264 (rank : 33)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	574	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

RGS3_MOUSE
NC score	0.030868 (rank : 34)	θ value	0.0563607 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	1621	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

MDC1_MOUSE
NC score	0.030510 (rank : 35)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	998	Shared Neighborhood Hits	55
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

LIPS_HUMAN
NC score	0.028450 (rank : 36)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

GRIN1_MOUSE
NC score	0.027598 (rank : 37)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	337	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

RFFL_HUMAN
NC score	0.027346 (rank : 38)	θ value	0.47712 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	175	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

TXND2_MOUSE
NC score	0.026626 (rank : 39)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	828	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

MDC1_HUMAN
NC score	0.025644 (rank : 40)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	1446	Shared Neighborhood Hits	56
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MINT_MOUSE
NC score	0.024687 (rank : 41)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	1514	Shared Neighborhood Hits	53
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

RTN4_MOUSE
NC score	0.023977 (rank : 42)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	341	Shared Neighborhood Hits	23
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

RTN2_MOUSE
NC score	0.022851 (rank : 43)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

RP1L1_MOUSE
NC score	0.022615 (rank : 44)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

MARCS_HUMAN
NC score	0.022564 (rank : 45)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	204	Shared Neighborhood Hits	17
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

SRCA_MOUSE
NC score	0.022318 (rank : 46)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	212	Shared Neighborhood Hits	22
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

AMPH_HUMAN
NC score	0.021834 (rank : 47)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	455	Shared Neighborhood Hits	29
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

SMRC2_MOUSE
NC score	0.021818 (rank : 48)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	487	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

TNNT2_MOUSE
NC score	0.020355 (rank : 49)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	395	Shared Neighborhood Hits	7
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

NCKX1_HUMAN
NC score	0.019467 (rank : 50)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	223	Shared Neighborhood Hits	15
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

TXLNB_HUMAN
NC score	0.019428 (rank : 51)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	912	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

SET1A_HUMAN
NC score	0.018952 (rank : 52)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	690	Shared Neighborhood Hits	32
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

EDRF1_MOUSE
NC score	0.018947 (rank : 53)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q6GQV7, Q80ZY3, Q8R3P5	Gene names	Edrf1
Domain Architecture	No domain graphic available
Description	Erythroid differentiation-related factor 1.

MAP2_HUMAN
NC score	0.018896 (rank : 54)	θ value	2.36792 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	348	Shared Neighborhood Hits	16
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

JIP2_MOUSE
NC score	0.018309 (rank : 55)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

HEXB_MOUSE
NC score	0.017708 (rank : 56)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P20060	Gene names	Hexb
Domain Architecture
Description	Beta-hexosaminidase beta chain precursor (EC 3.2.1.52) (N-acetyl-beta- glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase B).

MAGC1_HUMAN
NC score	0.017496 (rank : 57)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	431	Shared Neighborhood Hits	21
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

PHC2_HUMAN
NC score	0.017381 (rank : 58)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	388	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

CNGB1_HUMAN
NC score	0.017228 (rank : 59)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	222	Shared Neighborhood Hits	14
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

SAPS1_HUMAN
NC score	0.017012 (rank : 60)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	704	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

NCKX2_HUMAN
NC score	0.016760 (rank : 61)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UI40, Q9NTN5, Q9NZQ4	Gene names	SLC24A2, NCKX2
Domain Architecture
Description	Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2).

FA8_HUMAN
NC score	0.015558 (rank : 62)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	P00451	Gene names	F8, F8C
Domain Architecture
Description	Coagulation factor VIII precursor (Procoagulant component) (Antihemophilic factor) (AHF) [Contains: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain].

BIR1G_MOUSE
NC score	0.015034 (rank : 63)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	92	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BCLF1_HUMAN
NC score	0.014683 (rank : 64)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	298	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

BIR1F_MOUSE
NC score	0.014592 (rank : 65)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.014569 (rank : 66)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

TNNT2_HUMAN
NC score	0.014301 (rank : 67)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

DNM3A_MOUSE
NC score	0.013826 (rank : 68)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

NBN_HUMAN
NC score	0.013671 (rank : 69)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	226	Shared Neighborhood Hits	14
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

ANR41_HUMAN
NC score	0.013031 (rank : 70)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

IASPP_MOUSE
NC score	0.012794 (rank : 71)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	1024	Shared Neighborhood Hits	25
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NFH_HUMAN
NC score	0.012748 (rank : 72)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	1242	Shared Neighborhood Hits	34
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

BRD3_HUMAN
NC score	0.012711 (rank : 73)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	369	Shared Neighborhood Hits	12
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

HCN2_HUMAN
NC score	0.012573 (rank : 74)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	369	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

MAGB6_HUMAN
NC score	0.012050 (rank : 75)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	184	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

DNM3A_HUMAN
NC score	0.011908 (rank : 76)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	104	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

RBM19_MOUSE
NC score	0.011827 (rank : 77)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	296	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R3C6, Q8BHR0, Q9CW63	Gene names	Rbm19
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

BRD3_MOUSE
NC score	0.011619 (rank : 78)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	402	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

CMTA2_MOUSE
NC score	0.011349 (rank : 79)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	216	Shared Neighborhood Hits	12
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

RGP2_HUMAN
NC score	0.010950 (rank : 80)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

DHX57_MOUSE
NC score	0.010795 (rank : 81)	θ value	1.06291 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

RPGR1_MOUSE
NC score	0.010538 (rank : 82)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	713	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

MAGD1_HUMAN
NC score	0.010494 (rank : 83)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	130	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

MYST4_HUMAN
NC score	0.010477 (rank : 84)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	671	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

AP3B2_MOUSE
NC score	0.010116 (rank : 85)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	246	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

ZN326_MOUSE
NC score	0.010098 (rank : 86)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	7
SwissProt Accessions	O88291, Q8BSJ5, Q8K1X9, Q9CYG9	Gene names	Znf326, Zan75, Zfp326
Domain Architecture	No domain graphic available
Description	Zinc finger protein 326 (Zinc finger protein-associated with nuclear matrix of 75 kDa).

GNDS_HUMAN
NC score	0.009612 (rank : 87)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	201	Shared Neighborhood Hits	10
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

DDX21_MOUSE
NC score	0.009309 (rank : 88)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	350	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

AIPL1_HUMAN
NC score	0.009041 (rank : 89)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN9, Q9H873, Q9NS10	Gene names	AIPL1
Domain Architecture
Description	Aryl-hydrocarbon-interacting protein-like 1.

RYR1_HUMAN
NC score	0.008979 (rank : 90)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	303	Shared Neighborhood Hits	12
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

NFM_HUMAN
NC score	0.008977 (rank : 91)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	1328	Shared Neighborhood Hits	38
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

WNK2_HUMAN
NC score	0.008871 (rank : 92)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	1407	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

COFA1_HUMAN
NC score	0.008309 (rank : 93)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	292	Shared Neighborhood Hits	14
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

NVL_HUMAN
NC score	0.008034 (rank : 94)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	6
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

ACK1_HUMAN
NC score	0.007677 (rank : 95)	θ value	0.0431538 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	1140	Shared Neighborhood Hits	20
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

SART3_HUMAN
NC score	0.007568 (rank : 96)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	301	Shared Neighborhood Hits	4
SwissProt Accessions	Q15020, Q58F06, Q8IUS1, Q96J95	Gene names	SART3, KIAA0156, TIP110
Domain Architecture	No domain graphic available
Description	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (hSART-3) (Tat-interacting protein of 110 kDa) (Tip110).

TTBK1_HUMAN
NC score	0.007246 (rank : 97)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	1058	Shared Neighborhood Hits	25
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

CHD4_MOUSE
NC score	0.006938 (rank : 98)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	408	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

TJAP1_MOUSE
NC score	0.006927 (rank : 99)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

CHFR_HUMAN
NC score	0.006681 (rank : 100)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

LRCH4_HUMAN
NC score	0.006579 (rank : 101)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	O75427, Q8WV85, Q96ID0	Gene names	LRCH4, LRN, LRRN4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4 (Leucine-rich neuronal protein).

IC1_MOUSE
NC score	0.004840 (rank : 102)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	164	Shared Neighborhood Hits	9
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

ACK1_MOUSE
NC score	0.004642 (rank : 103)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	1080	Shared Neighborhood Hits	18
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

CAMKV_HUMAN
NC score	0.003764 (rank : 104)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	1084	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

NALP5_HUMAN
NC score	0.003517 (rank : 105)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

PP16A_MOUSE
NC score	0.002953 (rank : 106)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	318	Shared Neighborhood Hits	5
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

CD2L1_HUMAN
NC score	0.001429 (rank : 107)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	1467	Shared Neighborhood Hits	24
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

NKX28_MOUSE
NC score	0.000441 (rank : 108)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	347	Shared Neighborhood Hits	2
SwissProt Accessions	O70584	Gene names	Nkx2-8, Nkx-2.9, Nkx2-9, Nkx2h
Domain Architecture
Description	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H) (Homeobox protein Nkx-2.9).

ZN202_HUMAN
NC score	-0.002908 (rank : 109)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	756	Shared Neighborhood Hits	5
SwissProt Accessions	O95125, Q4JG21, Q9H1B9, Q9NSM4	Gene names	ZNF202
Domain Architecture
Description	Zinc finger protein 202.