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Network neighborhood for query Sequence : DNM3A_MOUSE

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DNM3A_MOUSE
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DNM3A_HUMAN
θ value	0 (rank : 1)	NC score	0.987655 (rank : 2)
Query Neighborhood Hits	91	Target Neighborhood Hits	104	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

DNM3A_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	91	Target Neighborhood Hits	91	Shared Neighborhood Hits	91
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

DNM3B_HUMAN
θ value	0 (rank : 3)	NC score	0.976314 (rank : 4)
Query Neighborhood Hits	91	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBC3, Q9UBD4, Q9UJQ5, Q9UKA6, Q9UNE5, Q9Y5R9, Q9Y5S0	Gene names	DNMT3B
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB).

DNM3B_MOUSE
θ value	0 (rank : 4)	NC score	0.976615 (rank : 3)
Query Neighborhood Hits	91	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	O88509, O88510, O88511	Gene names	Dnmt3b
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase MmuIIIB) (DNA MTase MmuIIIB) (M.MmuIIIB).

DNM3L_HUMAN
θ value	6.53529e-67 (rank : 5)	NC score	0.906775 (rank : 5)
Query Neighborhood Hits	91	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJW3, Q9BUJ4	Gene names	DNMT3L
Domain Architecture	No domain graphic available
Description	DNA (cytosine-5)-methyltransferase 3-like.

DNM3L_MOUSE
θ value	5.7252e-63 (rank : 6)	NC score	0.898085 (rank : 6)
Query Neighborhood Hits	91	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CWR8	Gene names	Dnmt3l
Domain Architecture	No domain graphic available
Description	DNA (cytosine-5)-methyltransferase 3-like.

PWWP2_HUMAN
θ value	1.133e-10 (rank : 7)	NC score	0.466598 (rank : 7)
Query Neighborhood Hits	91	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

ATRX_HUMAN
θ value	0.000461057 (rank : 8)	NC score	0.166204 (rank : 9)
Query Neighborhood Hits	91	Target Neighborhood Hits	842	Shared Neighborhood Hits	30
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

ATRX_MOUSE
θ value	0.000461057 (rank : 9)	NC score	0.169216 (rank : 8)
Query Neighborhood Hits	91	Target Neighborhood Hits	682	Shared Neighborhood Hits	35
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

RRBP1_HUMAN
θ value	0.00509761 (rank : 10)	NC score	0.029924 (rank : 41)
Query Neighborhood Hits	91	Target Neighborhood Hits	1306	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

MBD5_HUMAN
θ value	0.0193708 (rank : 11)	NC score	0.145812 (rank : 10)
Query Neighborhood Hits	91	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

CHD5_HUMAN
θ value	0.0330416 (rank : 12)	NC score	0.087813 (rank : 14)
Query Neighborhood Hits	91	Target Neighborhood Hits	349	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

MSH6_MOUSE
θ value	0.0431538 (rank : 13)	NC score	0.103051 (rank : 11)
Query Neighborhood Hits	91	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	P54276, O54710	Gene names	Msh6, Gtmbp
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

CHD3_HUMAN
θ value	0.0961366 (rank : 14)	NC score	0.083943 (rank : 17)
Query Neighborhood Hits	91	Target Neighborhood Hits	397	Shared Neighborhood Hits	29
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CHD4_HUMAN
θ value	0.0961366 (rank : 15)	NC score	0.083525 (rank : 19)
Query Neighborhood Hits	91	Target Neighborhood Hits	365	Shared Neighborhood Hits	31
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	0.0961366 (rank : 16)	NC score	0.083625 (rank : 18)
Query Neighborhood Hits	91	Target Neighborhood Hits	408	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

MEFV_HUMAN
θ value	0.279714 (rank : 17)	NC score	0.014823 (rank : 67)
Query Neighborhood Hits	91	Target Neighborhood Hits	431	Shared Neighborhood Hits	7
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

TOIP2_MOUSE
θ value	0.279714 (rank : 18)	NC score	0.052529 (rank : 32)
Query Neighborhood Hits	91	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BYU6, Q6NY10, Q8BJP0	Gene names	Tor1aip2
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2.

SGOL2_MOUSE
θ value	0.365318 (rank : 19)	NC score	0.036883 (rank : 36)
Query Neighborhood Hits	91	Target Neighborhood Hits	112	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55	Gene names	Sgol2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2.

PDZD2_HUMAN
θ value	0.47712 (rank : 20)	NC score	0.022960 (rank : 51)
Query Neighborhood Hits	91	Target Neighborhood Hits	772	Shared Neighborhood Hits	26
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

RGS3_MOUSE
θ value	0.47712 (rank : 21)	NC score	0.024428 (rank : 47)
Query Neighborhood Hits	91	Target Neighborhood Hits	1621	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

C8AP2_MOUSE
θ value	0.62314 (rank : 22)	NC score	0.029160 (rank : 42)
Query Neighborhood Hits	91	Target Neighborhood Hits	405	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CS007_HUMAN
θ value	0.62314 (rank : 23)	NC score	0.040260 (rank : 33)
Query Neighborhood Hits	91	Target Neighborhood Hits	401	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

MRCKG_HUMAN
θ value	0.62314 (rank : 24)	NC score	0.004033 (rank : 86)
Query Neighborhood Hits	91	Target Neighborhood Hits	1519	Shared Neighborhood Hits	17
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PF21A_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.089004 (rank : 13)
Query Neighborhood Hits	91	Target Neighborhood Hits	303	Shared Neighborhood Hits	21
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

MSH6_HUMAN
θ value	0.813845 (rank : 26)	NC score	0.094091 (rank : 12)
Query Neighborhood Hits	91	Target Neighborhood Hits	81	Shared Neighborhood Hits	19
SwissProt Accessions	P52701, O43706, O43917, Q8TCX4, Q9BTB5	Gene names	MSH6, GTBP
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

RFX1_MOUSE
θ value	1.06291 (rank : 27)	NC score	0.021360 (rank : 53)
Query Neighborhood Hits	91	Target Neighborhood Hits	181	Shared Neighborhood Hits	10
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

TACC1_MOUSE
θ value	1.06291 (rank : 28)	NC score	0.016418 (rank : 60)
Query Neighborhood Hits	91	Target Neighborhood Hits	667	Shared Neighborhood Hits	11
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

INVS_HUMAN
θ value	1.38821 (rank : 29)	NC score	0.011242 (rank : 77)
Query Neighborhood Hits	91	Target Neighborhood Hits	455	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

BAT2_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.034529 (rank : 39)
Query Neighborhood Hits	91	Target Neighborhood Hits	947	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

HDGR3_HUMAN
θ value	1.81305 (rank : 31)	NC score	0.079467 (rank : 21)
Query Neighborhood Hits	91	Target Neighborhood Hits	60	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

HDGR3_MOUSE
θ value	1.81305 (rank : 32)	NC score	0.080292 (rank : 20)
Query Neighborhood Hits	91	Target Neighborhood Hits	42	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JMG7, Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7	Gene names	Hdgfrp3
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3).

K1949_MOUSE
θ value	1.81305 (rank : 33)	NC score	0.027382 (rank : 44)
Query Neighborhood Hits	91	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

PF21A_MOUSE
θ value	1.81305 (rank : 34)	NC score	0.086763 (rank : 15)
Query Neighborhood Hits	91	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

SRRM2_MOUSE
θ value	1.81305 (rank : 35)	NC score	0.026482 (rank : 45)
Query Neighborhood Hits	91	Target Neighborhood Hits	1470	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ST65G_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.036360 (rank : 37)
Query Neighborhood Hits	91	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O94864, Q6IB21, Q9H2T6	Gene names	SUPT7L, KIAA0764
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1).

ST65G_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.036331 (rank : 38)
Query Neighborhood Hits	91	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZV5	Gene names	Supt7l
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like).

TP53B_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.037617 (rank : 35)
Query Neighborhood Hits	91	Target Neighborhood Hits	413	Shared Neighborhood Hits	15
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

WNK2_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.007107 (rank : 83)
Query Neighborhood Hits	91	Target Neighborhood Hits	1407	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZBT45_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.004887 (rank : 85)
Query Neighborhood Hits	91	Target Neighborhood Hits	901	Shared Neighborhood Hits	11
SwissProt Accessions	Q96K62	Gene names	ZBTB45, ZNF499
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499).

ZCPW1_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.085168 (rank : 16)
Query Neighborhood Hits	91	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

GP124_MOUSE
θ value	2.36792 (rank : 42)	NC score	0.012096 (rank : 76)
Query Neighborhood Hits	91	Target Neighborhood Hits	423	Shared Neighborhood Hits	8
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

HGS_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.015448 (rank : 63)
Query Neighborhood Hits	91	Target Neighborhood Hits	517	Shared Neighborhood Hits	11
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

LAD1_MOUSE
θ value	2.36792 (rank : 44)	NC score	0.033844 (rank : 40)
Query Neighborhood Hits	91	Target Neighborhood Hits	391	Shared Neighborhood Hits	20
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

PSL1_HUMAN
θ value	2.36792 (rank : 45)	NC score	0.016896 (rank : 59)
Query Neighborhood Hits	91	Target Neighborhood Hits	650	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

SP110_HUMAN
θ value	2.36792 (rank : 46)	NC score	0.068632 (rank : 25)
Query Neighborhood Hits	91	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HB58, Q14976, Q14977, Q8WUZ6, Q9HCT8	Gene names	SP110
Domain Architecture
Description	Sp110 nuclear body protein (Speckled 110 kDa) (Transcriptional coactivator Sp110) (Interferon-induced protein 41/75).

TXND2_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.021051 (rank : 54)
Query Neighborhood Hits	91	Target Neighborhood Hits	793	Shared Neighborhood Hits	29
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ZFHX2_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.016247 (rank : 61)
Query Neighborhood Hits	91	Target Neighborhood Hits	1178	Shared Neighborhood Hits	16
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

ZMY11_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.077480 (rank : 22)
Query Neighborhood Hits	91	Target Neighborhood Hits	201	Shared Neighborhood Hits	28
SwissProt Accessions	Q15326	Gene names	ZMYND11, BS69
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A- binding protein) (BS69 protein).

ZMY11_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.076640 (rank : 23)
Query Neighborhood Hits	91	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5C8, Q8C155	Gene names	Zmynd11
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11.

ZN335_HUMAN
θ value	2.36792 (rank : 51)	NC score	0.000689 (rank : 92)
Query Neighborhood Hits	91	Target Neighborhood Hits	973	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

ANK2_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.015037 (rank : 65)
Query Neighborhood Hits	91	Target Neighborhood Hits	1615	Shared Neighborhood Hits	35
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CASC3_MOUSE
θ value	3.0926 (rank : 53)	NC score	0.021552 (rank : 52)
Query Neighborhood Hits	91	Target Neighborhood Hits	333	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

KSR1_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.003437 (rank : 89)
Query Neighborhood Hits	91	Target Neighborhood Hits	870	Shared Neighborhood Hits	11
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

LRC50_MOUSE
θ value	3.0926 (rank : 55)	NC score	0.014743 (rank : 68)
Query Neighborhood Hits	91	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

NSD1_HUMAN
θ value	3.0926 (rank : 56)	NC score	0.062965 (rank : 29)
Query Neighborhood Hits	91	Target Neighborhood Hits	427	Shared Neighborhood Hits	42
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

PCLO_MOUSE
θ value	3.0926 (rank : 57)	NC score	0.016114 (rank : 62)
Query Neighborhood Hits	91	Target Neighborhood Hits	2275	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PSIP1_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.065893 (rank : 26)
Query Neighborhood Hits	91	Target Neighborhood Hits	313	Shared Neighborhood Hits	30
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

SYTL2_HUMAN
θ value	3.0926 (rank : 59)	NC score	0.010916 (rank : 78)
Query Neighborhood Hits	91	Target Neighborhood Hits	248	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TCAL5_HUMAN
θ value	3.0926 (rank : 60)	NC score	0.024123 (rank : 48)
Query Neighborhood Hits	91	Target Neighborhood Hits	806	Shared Neighborhood Hits	28
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TMAP1_HUMAN
θ value	3.0926 (rank : 61)	NC score	0.065241 (rank : 27)
Query Neighborhood Hits	91	Target Neighborhood Hits	140	Shared Neighborhood Hits	16
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

ZCPW1_MOUSE
θ value	3.0926 (rank : 62)	NC score	0.065228 (rank : 28)
Query Neighborhood Hits	91	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

CSKI2_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.012234 (rank : 74)
Query Neighborhood Hits	91	Target Neighborhood Hits	747	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

LAD1_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.027806 (rank : 43)
Query Neighborhood Hits	91	Target Neighborhood Hits	441	Shared Neighborhood Hits	19
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

LSD1_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.012101 (rank : 75)
Query Neighborhood Hits	91	Target Neighborhood Hits	455	Shared Neighborhood Hits	12
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

PAK4_MOUSE
θ value	4.03905 (rank : 66)	NC score	0.001722 (rank : 90)
Query Neighborhood Hits	91	Target Neighborhood Hits	1098	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PI51C_HUMAN
θ value	4.03905 (rank : 67)	NC score	0.013826 (rank : 69)
Query Neighborhood Hits	91	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PRGR_HUMAN
θ value	4.03905 (rank : 68)	NC score	0.012591 (rank : 73)
Query Neighborhood Hits	91	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

REN3A_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.020181 (rank : 55)
Query Neighborhood Hits	91	Target Neighborhood Hits	248	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H1J1, Q5T8C3, Q5T8C9, Q7Z6N3, Q86YK1, Q9BZI8	Gene names	UPF3A, RENT3A, UPF3
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3).

WDR46_MOUSE
θ value	4.03905 (rank : 70)	NC score	0.023242 (rank : 50)
Query Neighborhood Hits	91	Target Neighborhood Hits	243	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

AT1B4_MOUSE
θ value	5.27518 (rank : 71)	NC score	0.014837 (rank : 66)
Query Neighborhood Hits	91	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q99ME6, Q99ME5	Gene names	Atp1b4
Domain Architecture
Description	X/potassium-transporting ATPase subunit beta-m (X,K-ATPase beta-m subunit).

CD008_HUMAN
θ value	5.27518 (rank : 72)	NC score	0.019751 (rank : 57)
Query Neighborhood Hits	91	Target Neighborhood Hits	330	Shared Neighborhood Hits	13
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

EHMT2_MOUSE
θ value	5.27518 (rank : 73)	NC score	0.008422 (rank : 81)
Query Neighborhood Hits	91	Target Neighborhood Hits	750	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

LY10_HUMAN
θ value	5.27518 (rank : 74)	NC score	0.040254 (rank : 34)
Query Neighborhood Hits	91	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q13342, Q13341, Q92881, Q96TG3	Gene names	SP140, LYSP100
Domain Architecture
Description	Nuclear body protein SP140 (Nuclear autoantigen Sp-140) (Speckled 140 kDa) (LYSp100 protein) (Lymphoid-restricted homolog of Sp100).

MDC1_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.019327 (rank : 58)
Query Neighborhood Hits	91	Target Neighborhood Hits	998	Shared Neighborhood Hits	34
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PSIP1_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.055049 (rank : 31)
Query Neighborhood Hits	91	Target Neighborhood Hits	341	Shared Neighborhood Hits	28
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

BAT2_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.024102 (rank : 49)
Query Neighborhood Hits	91	Target Neighborhood Hits	931	Shared Neighborhood Hits	31
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BCL7C_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.025030 (rank : 46)
Query Neighborhood Hits	91	Target Neighborhood Hits	170	Shared Neighborhood Hits	8
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

BRSK1_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.001173 (rank : 91)
Query Neighborhood Hits	91	Target Neighborhood Hits	942	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CSKI2_MOUSE
θ value	6.88961 (rank : 80)	NC score	0.009648 (rank : 79)
Query Neighborhood Hits	91	Target Neighborhood Hits	812	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ELOA3_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.012996 (rank : 71)
Query Neighborhood Hits	91	Target Neighborhood Hits	98	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

KC1D_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.003647 (rank : 87)
Query Neighborhood Hits	91	Target Neighborhood Hits	737	Shared Neighborhood Hits	8
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.003647 (rank : 88)
Query Neighborhood Hits	91	Target Neighborhood Hits	737	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

RP3A_MOUSE
θ value	6.88961 (rank : 84)	NC score	0.007922 (rank : 82)
Query Neighborhood Hits	91	Target Neighborhood Hits	510	Shared Neighborhood Hits	19
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

WDR81_MOUSE
θ value	6.88961 (rank : 85)	NC score	0.012816 (rank : 72)
Query Neighborhood Hits	91	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

ES8L1_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.005533 (rank : 84)
Query Neighborhood Hits	91	Target Neighborhood Hits	143	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

HGS_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.013322 (rank : 70)
Query Neighborhood Hits	91	Target Neighborhood Hits	589	Shared Neighborhood Hits	17
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

MYLK_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.000184 (rank : 93)
Query Neighborhood Hits	91	Target Neighborhood Hits	1328	Shared Neighborhood Hits	15
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

RRBP1_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.019937 (rank : 56)
Query Neighborhood Hits	91	Target Neighborhood Hits	1650	Shared Neighborhood Hits	30
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

SASH1_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.008666 (rank : 80)
Query Neighborhood Hits	91	Target Neighborhood Hits	292	Shared Neighborhood Hits	12
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

ZN638_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.015191 (rank : 64)
Query Neighborhood Hits	91	Target Neighborhood Hits	343	Shared Neighborhood Hits	9
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

HDGF_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.075210 (rank : 24)
Query Neighborhood Hits	91	Target Neighborhood Hits	61	Shared Neighborhood Hits	18
SwissProt Accessions	P51858, Q5SZ09	Gene names	HDGF, HMG1L2
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF) (High-mobility group protein 1- like 2) (HMG-1L2).

HDGF_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.059220 (rank : 30)
Query Neighborhood Hits	91	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	P51859, Q8BPG7, Q9CYA4, Q9JK87	Gene names	Hdgf, Tdrm1
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF).

Hits sorted by NC score

DNM3A_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	91	Target Neighborhood Hits	91	Shared Neighborhood Hits	91
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

DNM3A_HUMAN
NC score	0.987655 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	91	Target Neighborhood Hits	104	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

DNM3B_MOUSE
NC score	0.976615 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	91	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	O88509, O88510, O88511	Gene names	Dnmt3b
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase MmuIIIB) (DNA MTase MmuIIIB) (M.MmuIIIB).

DNM3B_HUMAN
NC score	0.976314 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	91	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBC3, Q9UBD4, Q9UJQ5, Q9UKA6, Q9UNE5, Q9Y5R9, Q9Y5S0	Gene names	DNMT3B
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB).

DNM3L_HUMAN
NC score	0.906775 (rank : 5)	θ value	6.53529e-67 (rank : 5)
Query Neighborhood Hits	91	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJW3, Q9BUJ4	Gene names	DNMT3L
Domain Architecture	No domain graphic available
Description	DNA (cytosine-5)-methyltransferase 3-like.

DNM3L_MOUSE
NC score	0.898085 (rank : 6)	θ value	5.7252e-63 (rank : 6)
Query Neighborhood Hits	91	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CWR8	Gene names	Dnmt3l
Domain Architecture	No domain graphic available
Description	DNA (cytosine-5)-methyltransferase 3-like.

PWWP2_HUMAN
NC score	0.466598 (rank : 7)	θ value	1.133e-10 (rank : 7)
Query Neighborhood Hits	91	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

ATRX_MOUSE
NC score	0.169216 (rank : 8)	θ value	0.000461057 (rank : 9)
Query Neighborhood Hits	91	Target Neighborhood Hits	682	Shared Neighborhood Hits	35
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

ATRX_HUMAN
NC score	0.166204 (rank : 9)	θ value	0.000461057 (rank : 8)
Query Neighborhood Hits	91	Target Neighborhood Hits	842	Shared Neighborhood Hits	30
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

MBD5_HUMAN
NC score	0.145812 (rank : 10)	θ value	0.0193708 (rank : 11)
Query Neighborhood Hits	91	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

MSH6_MOUSE
NC score	0.103051 (rank : 11)	θ value	0.0431538 (rank : 13)
Query Neighborhood Hits	91	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	P54276, O54710	Gene names	Msh6, Gtmbp
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

MSH6_HUMAN
NC score	0.094091 (rank : 12)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	91	Target Neighborhood Hits	81	Shared Neighborhood Hits	19
SwissProt Accessions	P52701, O43706, O43917, Q8TCX4, Q9BTB5	Gene names	MSH6, GTBP
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

PF21A_HUMAN
NC score	0.089004 (rank : 13)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	91	Target Neighborhood Hits	303	Shared Neighborhood Hits	21
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

CHD5_HUMAN
NC score	0.087813 (rank : 14)	θ value	0.0330416 (rank : 12)
Query Neighborhood Hits	91	Target Neighborhood Hits	349	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

PF21A_MOUSE
NC score	0.086763 (rank : 15)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	91	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

ZCPW1_HUMAN
NC score	0.085168 (rank : 16)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	91	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

CHD3_HUMAN
NC score	0.083943 (rank : 17)	θ value	0.0961366 (rank : 14)
Query Neighborhood Hits	91	Target Neighborhood Hits	397	Shared Neighborhood Hits	29
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CHD4_MOUSE
NC score	0.083625 (rank : 18)	θ value	0.0961366 (rank : 16)
Query Neighborhood Hits	91	Target Neighborhood Hits	408	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CHD4_HUMAN
NC score	0.083525 (rank : 19)	θ value	0.0961366 (rank : 15)
Query Neighborhood Hits	91	Target Neighborhood Hits	365	Shared Neighborhood Hits	31
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

HDGR3_MOUSE
NC score	0.080292 (rank : 20)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	91	Target Neighborhood Hits	42	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JMG7, Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7	Gene names	Hdgfrp3
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3).

HDGR3_HUMAN
NC score	0.079467 (rank : 21)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	91	Target Neighborhood Hits	60	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

ZMY11_HUMAN
NC score	0.077480 (rank : 22)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	91	Target Neighborhood Hits	201	Shared Neighborhood Hits	28
SwissProt Accessions	Q15326	Gene names	ZMYND11, BS69
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A- binding protein) (BS69 protein).

ZMY11_MOUSE
NC score	0.076640 (rank : 23)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	91	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5C8, Q8C155	Gene names	Zmynd11
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11.

HDGF_HUMAN
NC score	0.075210 (rank : 24)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	91	Target Neighborhood Hits	61	Shared Neighborhood Hits	18
SwissProt Accessions	P51858, Q5SZ09	Gene names	HDGF, HMG1L2
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF) (High-mobility group protein 1- like 2) (HMG-1L2).

SP110_HUMAN
NC score	0.068632 (rank : 25)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	91	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HB58, Q14976, Q14977, Q8WUZ6, Q9HCT8	Gene names	SP110
Domain Architecture
Description	Sp110 nuclear body protein (Speckled 110 kDa) (Transcriptional coactivator Sp110) (Interferon-induced protein 41/75).

PSIP1_MOUSE
NC score	0.065893 (rank : 26)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	91	Target Neighborhood Hits	313	Shared Neighborhood Hits	30
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

TMAP1_HUMAN
NC score	0.065241 (rank : 27)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	91	Target Neighborhood Hits	140	Shared Neighborhood Hits	16
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

ZCPW1_MOUSE
NC score	0.065228 (rank : 28)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	91	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

NSD1_HUMAN
NC score	0.062965 (rank : 29)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	91	Target Neighborhood Hits	427	Shared Neighborhood Hits	42
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

HDGF_MOUSE
NC score	0.059220 (rank : 30)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	91	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	P51859, Q8BPG7, Q9CYA4, Q9JK87	Gene names	Hdgf, Tdrm1
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF).

PSIP1_HUMAN
NC score	0.055049 (rank : 31)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	91	Target Neighborhood Hits	341	Shared Neighborhood Hits	28
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

TOIP2_MOUSE
NC score	0.052529 (rank : 32)	θ value	0.279714 (rank : 18)
Query Neighborhood Hits	91	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BYU6, Q6NY10, Q8BJP0	Gene names	Tor1aip2
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2.

CS007_HUMAN
NC score	0.040260 (rank : 33)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	91	Target Neighborhood Hits	401	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

LY10_HUMAN
NC score	0.040254 (rank : 34)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	91	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q13342, Q13341, Q92881, Q96TG3	Gene names	SP140, LYSP100
Domain Architecture
Description	Nuclear body protein SP140 (Nuclear autoantigen Sp-140) (Speckled 140 kDa) (LYSp100 protein) (Lymphoid-restricted homolog of Sp100).

TP53B_HUMAN
NC score	0.037617 (rank : 35)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	91	Target Neighborhood Hits	413	Shared Neighborhood Hits	15
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

SGOL2_MOUSE
NC score	0.036883 (rank : 36)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	91	Target Neighborhood Hits	112	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55	Gene names	Sgol2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2.

ST65G_HUMAN
NC score	0.036360 (rank : 37)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	91	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O94864, Q6IB21, Q9H2T6	Gene names	SUPT7L, KIAA0764
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1).

ST65G_MOUSE
NC score	0.036331 (rank : 38)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	91	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZV5	Gene names	Supt7l
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like).

BAT2_MOUSE
NC score	0.034529 (rank : 39)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	91	Target Neighborhood Hits	947	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

LAD1_MOUSE
NC score	0.033844 (rank : 40)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	91	Target Neighborhood Hits	391	Shared Neighborhood Hits	20
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

RRBP1_HUMAN
NC score	0.029924 (rank : 41)	θ value	0.00509761 (rank : 10)
Query Neighborhood Hits	91	Target Neighborhood Hits	1306	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

C8AP2_MOUSE
NC score	0.029160 (rank : 42)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	91	Target Neighborhood Hits	405	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

LAD1_HUMAN
NC score	0.027806 (rank : 43)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	91	Target Neighborhood Hits	441	Shared Neighborhood Hits	19
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

K1949_MOUSE
NC score	0.027382 (rank : 44)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	91	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

SRRM2_MOUSE
NC score	0.026482 (rank : 45)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	91	Target Neighborhood Hits	1470	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

BCL7C_MOUSE
NC score	0.025030 (rank : 46)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	91	Target Neighborhood Hits	170	Shared Neighborhood Hits	8
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

RGS3_MOUSE
NC score	0.024428 (rank : 47)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	91	Target Neighborhood Hits	1621	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TCAL5_HUMAN
NC score	0.024123 (rank : 48)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	91	Target Neighborhood Hits	806	Shared Neighborhood Hits	28
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

BAT2_HUMAN
NC score	0.024102 (rank : 49)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	91	Target Neighborhood Hits	931	Shared Neighborhood Hits	31
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

WDR46_MOUSE
NC score	0.023242 (rank : 50)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	91	Target Neighborhood Hits	243	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

PDZD2_HUMAN
NC score	0.022960 (rank : 51)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	91	Target Neighborhood Hits	772	Shared Neighborhood Hits	26
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

CASC3_MOUSE
NC score	0.021552 (rank : 52)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	91	Target Neighborhood Hits	333	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

RFX1_MOUSE
NC score	0.021360 (rank : 53)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	91	Target Neighborhood Hits	181	Shared Neighborhood Hits	10
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

TXND2_HUMAN
NC score	0.021051 (rank : 54)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	91	Target Neighborhood Hits	793	Shared Neighborhood Hits	29
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

REN3A_HUMAN
NC score	0.020181 (rank : 55)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	91	Target Neighborhood Hits	248	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H1J1, Q5T8C3, Q5T8C9, Q7Z6N3, Q86YK1, Q9BZI8	Gene names	UPF3A, RENT3A, UPF3
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3).

RRBP1_MOUSE
NC score	0.019937 (rank : 56)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	91	Target Neighborhood Hits	1650	Shared Neighborhood Hits	30
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

CD008_HUMAN
NC score	0.019751 (rank : 57)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	91	Target Neighborhood Hits	330	Shared Neighborhood Hits	13
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

MDC1_MOUSE
NC score	0.019327 (rank : 58)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	91	Target Neighborhood Hits	998	Shared Neighborhood Hits	34
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PSL1_HUMAN
NC score	0.016896 (rank : 59)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	91	Target Neighborhood Hits	650	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

TACC1_MOUSE
NC score	0.016418 (rank : 60)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	91	Target Neighborhood Hits	667	Shared Neighborhood Hits	11
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

ZFHX2_HUMAN
NC score	0.016247 (rank : 61)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	91	Target Neighborhood Hits	1178	Shared Neighborhood Hits	16
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

PCLO_MOUSE
NC score	0.016114 (rank : 62)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	91	Target Neighborhood Hits	2275	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

HGS_HUMAN
NC score	0.015448 (rank : 63)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	91	Target Neighborhood Hits	517	Shared Neighborhood Hits	11
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ZN638_HUMAN
NC score	0.015191 (rank : 64)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	91	Target Neighborhood Hits	343	Shared Neighborhood Hits	9
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

ANK2_HUMAN
NC score	0.015037 (rank : 65)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	91	Target Neighborhood Hits	1615	Shared Neighborhood Hits	35
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

AT1B4_MOUSE
NC score	0.014837 (rank : 66)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	91	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q99ME6, Q99ME5	Gene names	Atp1b4
Domain Architecture
Description	X/potassium-transporting ATPase subunit beta-m (X,K-ATPase beta-m subunit).

MEFV_HUMAN
NC score	0.014823 (rank : 67)	θ value	0.279714 (rank : 17)
Query Neighborhood Hits	91	Target Neighborhood Hits	431	Shared Neighborhood Hits	7
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LRC50_MOUSE
NC score	0.014743 (rank : 68)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	91	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

PI51C_HUMAN
NC score	0.013826 (rank : 69)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	91	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

HGS_MOUSE
NC score	0.013322 (rank : 70)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	91	Target Neighborhood Hits	589	Shared Neighborhood Hits	17
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

ELOA3_HUMAN
NC score	0.012996 (rank : 71)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	91	Target Neighborhood Hits	98	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

WDR81_MOUSE
NC score	0.012816 (rank : 72)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	91	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

PRGR_HUMAN
NC score	0.012591 (rank : 73)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	91	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

CSKI2_HUMAN
NC score	0.012234 (rank : 74)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	91	Target Neighborhood Hits	747	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

LSD1_HUMAN
NC score	0.012101 (rank : 75)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	91	Target Neighborhood Hits	455	Shared Neighborhood Hits	12
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

GP124_MOUSE
NC score	0.012096 (rank : 76)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	91	Target Neighborhood Hits	423	Shared Neighborhood Hits	8
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

INVS_HUMAN
NC score	0.011242 (rank : 77)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	91	Target Neighborhood Hits	455	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

SYTL2_HUMAN
NC score	0.010916 (rank : 78)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	91	Target Neighborhood Hits	248	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CSKI2_MOUSE
NC score	0.009648 (rank : 79)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	91	Target Neighborhood Hits	812	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

SASH1_HUMAN
NC score	0.008666 (rank : 80)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	91	Target Neighborhood Hits	292	Shared Neighborhood Hits	12
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

EHMT2_MOUSE
NC score	0.008422 (rank : 81)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	91	Target Neighborhood Hits	750	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

RP3A_MOUSE
NC score	0.007922 (rank : 82)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	91	Target Neighborhood Hits	510	Shared Neighborhood Hits	19
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

WNK2_HUMAN
NC score	0.007107 (rank : 83)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	91	Target Neighborhood Hits	1407	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ES8L1_MOUSE
NC score	0.005533 (rank : 84)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	91	Target Neighborhood Hits	143	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ZBT45_HUMAN
NC score	0.004887 (rank : 85)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	91	Target Neighborhood Hits	901	Shared Neighborhood Hits	11
SwissProt Accessions	Q96K62	Gene names	ZBTB45, ZNF499
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499).

MRCKG_HUMAN
NC score	0.004033 (rank : 86)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	91	Target Neighborhood Hits	1519	Shared Neighborhood Hits	17
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KC1D_HUMAN
NC score	0.003647 (rank : 87)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	91	Target Neighborhood Hits	737	Shared Neighborhood Hits	8
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.003647 (rank : 88)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	91	Target Neighborhood Hits	737	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KSR1_MOUSE
NC score	0.003437 (rank : 89)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	91	Target Neighborhood Hits	870	Shared Neighborhood Hits	11
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

PAK4_MOUSE
NC score	0.001722 (rank : 90)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	91	Target Neighborhood Hits	1098	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

BRSK1_HUMAN
NC score	0.001173 (rank : 91)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	91	Target Neighborhood Hits	942	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

ZN335_HUMAN
NC score	0.000689 (rank : 92)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	91	Target Neighborhood Hits	973	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

MYLK_HUMAN
NC score	0.000184 (rank : 93)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	91	Target Neighborhood Hits	1328	Shared Neighborhood Hits	15
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).