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Network neighborhood for query Sequence : ES8L1_MOUSE

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ES8L1_MOUSE
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ES8L1_HUMAN
θ value	0 (rank : 1)	NC score	0.983195 (rank : 2)
Query Neighborhood Hits	143	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	143	Target Neighborhood Hits	143	Shared Neighborhood Hits	143
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_MOUSE
θ value	3.4095e-124 (rank : 3)	NC score	0.933261 (rank : 3)
Query Neighborhood Hits	143	Target Neighborhood Hits	169	Shared Neighborhood Hits	86
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_HUMAN
θ value	6.65404e-120 (rank : 4)	NC score	0.926571 (rank : 5)
Query Neighborhood Hits	143	Target Neighborhood Hits	193	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_MOUSE
θ value	6.228e-118 (rank : 5)	NC score	0.932280 (rank : 4)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	80
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_HUMAN
θ value	9.30652e-114 (rank : 6)	NC score	0.926461 (rank : 6)
Query Neighborhood Hits	143	Target Neighborhood Hits	151	Shared Neighborhood Hits	76
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L3_HUMAN
θ value	1.41016e-61 (rank : 7)	NC score	0.877954 (rank : 8)
Query Neighborhood Hits	143	Target Neighborhood Hits	206	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	2.32979e-56 (rank : 8)	NC score	0.889122 (rank : 7)
Query Neighborhood Hits	143	Target Neighborhood Hits	168	Shared Neighborhood Hits	91
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

STAM2_MOUSE
θ value	4.45536e-07 (rank : 9)	NC score	0.319461 (rank : 13)
Query Neighborhood Hits	143	Target Neighborhood Hits	285	Shared Neighborhood Hits	94
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
θ value	2.21117e-06 (rank : 10)	NC score	0.315517 (rank : 15)
Query Neighborhood Hits	143	Target Neighborhood Hits	288	Shared Neighborhood Hits	95
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM1_MOUSE
θ value	8.40245e-06 (rank : 11)	NC score	0.304722 (rank : 18)
Query Neighborhood Hits	143	Target Neighborhood Hits	273	Shared Neighborhood Hits	93
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCK2_HUMAN
θ value	3.19293e-05 (rank : 12)	NC score	0.373109 (rank : 9)
Query Neighborhood Hits	143	Target Neighborhood Hits	310	Shared Neighborhood Hits	98
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

BTK_HUMAN
θ value	5.44631e-05 (rank : 13)	NC score	0.141618 (rank : 101)
Query Neighborhood Hits	143	Target Neighborhood Hits	1026	Shared Neighborhood Hits	96
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	5.44631e-05 (rank : 14)	NC score	0.141160 (rank : 102)
Query Neighborhood Hits	143	Target Neighborhood Hits	1017	Shared Neighborhood Hits	91
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

NCK1_HUMAN
θ value	7.1131e-05 (rank : 15)	NC score	0.359922 (rank : 10)
Query Neighborhood Hits	143	Target Neighborhood Hits	312	Shared Neighborhood Hits	95
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

TEC_HUMAN
θ value	7.1131e-05 (rank : 16)	NC score	0.122013 (rank : 124)
Query Neighborhood Hits	143	Target Neighborhood Hits	1006	Shared Neighborhood Hits	86
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

NPHP1_HUMAN
θ value	9.29e-05 (rank : 17)	NC score	0.325557 (rank : 12)
Query Neighborhood Hits	143	Target Neighborhood Hits	288	Shared Neighborhood Hits	91
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RHG04_HUMAN
θ value	0.000158464 (rank : 18)	NC score	0.130989 (rank : 111)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SPTA1_MOUSE
θ value	0.00020696 (rank : 19)	NC score	0.174695 (rank : 52)
Query Neighborhood Hits	143	Target Neighborhood Hits	675	Shared Neighborhood Hits	94
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TEC_MOUSE
θ value	0.00020696 (rank : 20)	NC score	0.121250 (rank : 128)
Query Neighborhood Hits	143	Target Neighborhood Hits	1006	Shared Neighborhood Hits	83
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VINEX_MOUSE
θ value	0.00020696 (rank : 21)	NC score	0.273735 (rank : 29)
Query Neighborhood Hits	143	Target Neighborhood Hits	286	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ITSN2_HUMAN
θ value	0.000270298 (rank : 22)	NC score	0.181740 (rank : 48)
Query Neighborhood Hits	143	Target Neighborhood Hits	1173	Shared Neighborhood Hits	99
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

AHI1_HUMAN
θ value	0.00035302 (rank : 23)	NC score	0.229017 (rank : 34)
Query Neighborhood Hits	143	Target Neighborhood Hits	537	Shared Neighborhood Hits	97
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CRK_MOUSE
θ value	0.000461057 (rank : 24)	NC score	0.293299 (rank : 21)
Query Neighborhood Hits	143	Target Neighborhood Hits	314	Shared Neighborhood Hits	93
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ITSN1_HUMAN
θ value	0.000602161 (rank : 25)	NC score	0.170393 (rank : 59)
Query Neighborhood Hits	143	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SPTA1_HUMAN
θ value	0.000602161 (rank : 26)	NC score	0.146947 (rank : 84)
Query Neighborhood Hits	143	Target Neighborhood Hits	748	Shared Neighborhood Hits	90
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ITK_HUMAN
θ value	0.000786445 (rank : 27)	NC score	0.121367 (rank : 127)
Query Neighborhood Hits	143	Target Neighborhood Hits	1016	Shared Neighborhood Hits	86
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

STAM1_HUMAN
θ value	0.000786445 (rank : 28)	NC score	0.294599 (rank : 20)
Query Neighborhood Hits	143	Target Neighborhood Hits	271	Shared Neighborhood Hits	92
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP2_MOUSE
θ value	0.00102713 (rank : 29)	NC score	0.304758 (rank : 17)
Query Neighborhood Hits	143	Target Neighborhood Hits	297	Shared Neighborhood Hits	96
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

TXK_HUMAN
θ value	0.00102713 (rank : 30)	NC score	0.116237 (rank : 135)
Query Neighborhood Hits	143	Target Neighborhood Hits	971	Shared Neighborhood Hits	81
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

VINEX_HUMAN
θ value	0.00102713 (rank : 31)	NC score	0.248651 (rank : 30)
Query Neighborhood Hits	143	Target Neighborhood Hits	270	Shared Neighborhood Hits	93
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

BLK_MOUSE
θ value	0.00175202 (rank : 32)	NC score	0.129018 (rank : 113)
Query Neighborhood Hits	143	Target Neighborhood Hits	992	Shared Neighborhood Hits	82
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

GRB2_HUMAN
θ value	0.00228821 (rank : 33)	NC score	0.286067 (rank : 25)
Query Neighborhood Hits	143	Target Neighborhood Hits	310	Shared Neighborhood Hits	97
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00228821 (rank : 34)	NC score	0.284986 (rank : 26)
Query Neighborhood Hits	143	Target Neighborhood Hits	312	Shared Neighborhood Hits	97
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ITK_MOUSE
θ value	0.00298849 (rank : 35)	NC score	0.113114 (rank : 140)
Query Neighborhood Hits	143	Target Neighborhood Hits	985	Shared Neighborhood Hits	79
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITSN1_MOUSE
θ value	0.00298849 (rank : 36)	NC score	0.175755 (rank : 50)
Query Neighborhood Hits	143	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SPTA2_HUMAN
θ value	0.00298849 (rank : 37)	NC score	0.143437 (rank : 93)
Query Neighborhood Hits	143	Target Neighborhood Hits	888	Shared Neighborhood Hits	96
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ITSN2_MOUSE
θ value	0.00390308 (rank : 38)	NC score	0.169675 (rank : 62)
Query Neighborhood Hits	143	Target Neighborhood Hits	1371	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NPHP1_MOUSE
θ value	0.00509761 (rank : 39)	NC score	0.327458 (rank : 11)
Query Neighborhood Hits	143	Target Neighborhood Hits	267	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

GRAP2_HUMAN
θ value	0.0113563 (rank : 40)	NC score	0.303398 (rank : 19)
Query Neighborhood Hits	143	Target Neighborhood Hits	304	Shared Neighborhood Hits	96
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

AHI1_MOUSE
θ value	0.0148317 (rank : 41)	NC score	0.217013 (rank : 36)
Query Neighborhood Hits	143	Target Neighborhood Hits	496	Shared Neighborhood Hits	97
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

HCK_HUMAN
θ value	0.0148317 (rank : 42)	NC score	0.127598 (rank : 116)
Query Neighborhood Hits	143	Target Neighborhood Hits	1035	Shared Neighborhood Hits	94
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	0.0148317 (rank : 43)	NC score	0.125052 (rank : 119)
Query Neighborhood Hits	143	Target Neighborhood Hits	1029	Shared Neighborhood Hits	94
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

GRAP_MOUSE
θ value	0.0193708 (rank : 44)	NC score	0.278526 (rank : 28)
Query Neighborhood Hits	143	Target Neighborhood Hits	309	Shared Neighborhood Hits	95
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PPIP1_HUMAN
θ value	0.0193708 (rank : 45)	NC score	0.292280 (rank : 22)
Query Neighborhood Hits	143	Target Neighborhood Hits	389	Shared Neighborhood Hits	94
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PTK6_MOUSE
θ value	0.0193708 (rank : 46)	NC score	0.105092 (rank : 150)
Query Neighborhood Hits	143	Target Neighborhood Hits	1026	Shared Neighborhood Hits	87
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TXK_MOUSE
θ value	0.0193708 (rank : 47)	NC score	0.118106 (rank : 133)
Query Neighborhood Hits	143	Target Neighborhood Hits	980	Shared Neighborhood Hits	82
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BLK_HUMAN
θ value	0.0252991 (rank : 48)	NC score	0.125645 (rank : 118)
Query Neighborhood Hits	143	Target Neighborhood Hits	994	Shared Neighborhood Hits	83
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ASPP1_HUMAN
θ value	0.0330416 (rank : 49)	NC score	0.171109 (rank : 58)
Query Neighborhood Hits	143	Target Neighborhood Hits	956	Shared Neighborhood Hits	84
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CRK_HUMAN
θ value	0.0330416 (rank : 50)	NC score	0.288823 (rank : 24)
Query Neighborhood Hits	143	Target Neighborhood Hits	308	Shared Neighborhood Hits	94
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FGR_MOUSE
θ value	0.0330416 (rank : 51)	NC score	0.121627 (rank : 125)
Query Neighborhood Hits	143	Target Neighborhood Hits	1069	Shared Neighborhood Hits	94
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GRAP_HUMAN
θ value	0.0330416 (rank : 52)	NC score	0.288950 (rank : 23)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	97
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PPIP1_MOUSE
θ value	0.0330416 (rank : 53)	NC score	0.279748 (rank : 27)
Query Neighborhood Hits	143	Target Neighborhood Hits	377	Shared Neighborhood Hits	93
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SRC_MOUSE
θ value	0.0330416 (rank : 54)	NC score	0.116512 (rank : 134)
Query Neighborhood Hits	143	Target Neighborhood Hits	1033	Shared Neighborhood Hits	88
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

VAV_HUMAN
θ value	0.0330416 (rank : 55)	NC score	0.195815 (rank : 40)
Query Neighborhood Hits	143	Target Neighborhood Hits	452	Shared Neighborhood Hits	94
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ASPP1_MOUSE
θ value	0.0431538 (rank : 56)	NC score	0.161612 (rank : 69)
Query Neighborhood Hits	143	Target Neighborhood Hits	1244	Shared Neighborhood Hits	94
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	0.0431538 (rank : 57)	NC score	0.120337 (rank : 131)
Query Neighborhood Hits	143	Target Neighborhood Hits	1156	Shared Neighborhood Hits	83
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CAC1H_HUMAN
θ value	0.0563607 (rank : 58)	NC score	0.017186 (rank : 290)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	5
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

YES_HUMAN
θ value	0.0563607 (rank : 59)	NC score	0.123191 (rank : 122)
Query Neighborhood Hits	143	Target Neighborhood Hits	1059	Shared Neighborhood Hits	95
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.0563607 (rank : 60)	NC score	0.123431 (rank : 121)
Query Neighborhood Hits	143	Target Neighborhood Hits	1052	Shared Neighborhood Hits	95
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

DNMBP_HUMAN
θ value	0.0736092 (rank : 61)	NC score	0.235007 (rank : 33)
Query Neighborhood Hits	143	Target Neighborhood Hits	413	Shared Neighborhood Hits	98
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LCK_HUMAN
θ value	0.0736092 (rank : 62)	NC score	0.107952 (rank : 143)
Query Neighborhood Hits	143	Target Neighborhood Hits	987	Shared Neighborhood Hits	72
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

VAV_MOUSE
θ value	0.0961366 (rank : 63)	NC score	0.192849 (rank : 41)
Query Neighborhood Hits	143	Target Neighborhood Hits	430	Shared Neighborhood Hits	94
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

IASPP_HUMAN
θ value	0.125558 (rank : 64)	NC score	0.146917 (rank : 85)
Query Neighborhood Hits	143	Target Neighborhood Hits	688	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	0.125558 (rank : 65)	NC score	0.132198 (rank : 107)
Query Neighborhood Hits	143	Target Neighborhood Hits	1024	Shared Neighborhood Hits	93
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LCK_MOUSE
θ value	0.125558 (rank : 66)	NC score	0.106477 (rank : 147)
Query Neighborhood Hits	143	Target Neighborhood Hits	981	Shared Neighborhood Hits	72
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

NCF1_HUMAN
θ value	0.125558 (rank : 67)	NC score	0.239045 (rank : 32)
Query Neighborhood Hits	143	Target Neighborhood Hits	198	Shared Neighborhood Hits	85
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PTK6_HUMAN
θ value	0.125558 (rank : 68)	NC score	0.101072 (rank : 156)
Query Neighborhood Hits	143	Target Neighborhood Hits	1020	Shared Neighborhood Hits	87
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SRC_HUMAN
θ value	0.125558 (rank : 69)	NC score	0.120475 (rank : 130)
Query Neighborhood Hits	143	Target Neighborhood Hits	1058	Shared Neighborhood Hits	95
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

UBIP1_HUMAN
θ value	0.125558 (rank : 70)	NC score	0.053171 (rank : 247)
Query Neighborhood Hits	143	Target Neighborhood Hits	83	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZI7, Q68CT0, Q86Y57, Q9H8V0, Q9UD76, Q9UD78	Gene names	UBP1, LBP1
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (LBP-1).

CRKL_MOUSE
θ value	0.163984 (rank : 71)	NC score	0.314683 (rank : 16)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

FRK_HUMAN
θ value	0.163984 (rank : 72)	NC score	0.107621 (rank : 144)
Query Neighborhood Hits	143	Target Neighborhood Hits	1058	Shared Neighborhood Hits	93
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	0.163984 (rank : 73)	NC score	0.120965 (rank : 129)
Query Neighborhood Hits	143	Target Neighborhood Hits	1078	Shared Neighborhood Hits	95
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.163984 (rank : 74)	NC score	0.122903 (rank : 123)
Query Neighborhood Hits	143	Target Neighborhood Hits	1073	Shared Neighborhood Hits	95
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

PRPC_HUMAN
θ value	0.163984 (rank : 75)	NC score	0.047698 (rank : 271)
Query Neighborhood Hits	143	Target Neighborhood Hits	165	Shared Neighborhood Hits	14
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

CRKL_HUMAN
θ value	0.21417 (rank : 76)	NC score	0.316602 (rank : 14)
Query Neighborhood Hits	143	Target Neighborhood Hits	313	Shared Neighborhood Hits	95
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

MDC1_MOUSE
θ value	0.21417 (rank : 77)	NC score	0.022032 (rank : 280)
Query Neighborhood Hits	143	Target Neighborhood Hits	998	Shared Neighborhood Hits	21
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MEGF9_MOUSE
θ value	0.279714 (rank : 78)	NC score	0.012417 (rank : 297)
Query Neighborhood Hits	143	Target Neighborhood Hits	896	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MYO1F_HUMAN
θ value	0.279714 (rank : 79)	NC score	0.099502 (rank : 158)
Query Neighborhood Hits	143	Target Neighborhood Hits	275	Shared Neighborhood Hits	95
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	0.279714 (rank : 80)	NC score	0.101117 (rank : 155)
Query Neighborhood Hits	143	Target Neighborhood Hits	262	Shared Neighborhood Hits	93
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

UBIP1_MOUSE
θ value	0.279714 (rank : 81)	NC score	0.055340 (rank : 237)
Query Neighborhood Hits	143	Target Neighborhood Hits	90	Shared Neighborhood Hits	10
SwissProt Accessions	Q811S7, Q3UPR3, Q3US11, Q60786, Q8C514	Gene names	Ubp1, Cp2b, Nf2d9
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (Nuclear factor 2d9) (NF2d9).

ARHG7_MOUSE
θ value	0.62314 (rank : 82)	NC score	0.179719 (rank : 49)
Query Neighborhood Hits	143	Target Neighborhood Hits	396	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

AXN1_HUMAN
θ value	0.62314 (rank : 83)	NC score	0.027935 (rank : 273)
Query Neighborhood Hits	143	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

NCF1_MOUSE
θ value	0.813845 (rank : 84)	NC score	0.217181 (rank : 35)
Query Neighborhood Hits	143	Target Neighborhood Hits	198	Shared Neighborhood Hits	86
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SNX18_MOUSE
θ value	0.813845 (rank : 85)	NC score	0.171150 (rank : 57)
Query Neighborhood Hits	143	Target Neighborhood Hits	198	Shared Neighborhood Hits	66
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ZBT7B_MOUSE
θ value	0.813845 (rank : 86)	NC score	-0.001890 (rank : 312)
Query Neighborhood Hits	143	Target Neighborhood Hits	792	Shared Neighborhood Hits	3
SwissProt Accessions	Q64321, Q80VV5	Gene names	Zbtb7b, Thpok, Zfp67
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 7B (Zinc finger protein 67) (Zfp-67) (Zinc finger protein Th-POK) (T-helper-inducing POZ/Krueppel-like factor) (Krueppel-related zinc finger protein cKrox) (c-Krox).

DNMBP_MOUSE
θ value	1.06291 (rank : 87)	NC score	0.216898 (rank : 37)
Query Neighborhood Hits	143	Target Neighborhood Hits	435	Shared Neighborhood Hits	100
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EFS_MOUSE
θ value	1.06291 (rank : 88)	NC score	0.186512 (rank : 46)
Query Neighborhood Hits	143	Target Neighborhood Hits	389	Shared Neighborhood Hits	83
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SVIL_MOUSE
θ value	1.06291 (rank : 89)	NC score	0.022032 (rank : 279)
Query Neighborhood Hits	143	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

MYO1E_HUMAN
θ value	1.38821 (rank : 90)	NC score	0.085965 (rank : 177)
Query Neighborhood Hits	143	Target Neighborhood Hits	293	Shared Neighborhood Hits	90
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PACN2_MOUSE
θ value	1.38821 (rank : 91)	NC score	0.174109 (rank : 53)
Query Neighborhood Hits	143	Target Neighborhood Hits	382	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SNX18_HUMAN
θ value	1.38821 (rank : 92)	NC score	0.162008 (rank : 68)
Query Neighborhood Hits	143	Target Neighborhood Hits	207	Shared Neighborhood Hits	66
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

RIMB1_HUMAN
θ value	1.81305 (rank : 93)	NC score	0.055159 (rank : 238)
Query Neighborhood Hits	143	Target Neighborhood Hits	1479	Shared Neighborhood Hits	75
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SPEG_MOUSE
θ value	1.81305 (rank : 94)	NC score	0.020673 (rank : 287)
Query Neighborhood Hits	143	Target Neighborhood Hits	1959	Shared Neighborhood Hits	45
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CIP4_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.169697 (rank : 61)
Query Neighborhood Hits	143	Target Neighborhood Hits	374	Shared Neighborhood Hits	59
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

EFS_HUMAN
θ value	2.36792 (rank : 96)	NC score	0.170050 (rank : 60)
Query Neighborhood Hits	143	Target Neighborhood Hits	348	Shared Neighborhood Hits	83
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

FYB_HUMAN
θ value	2.36792 (rank : 97)	NC score	0.035902 (rank : 272)
Query Neighborhood Hits	143	Target Neighborhood Hits	379	Shared Neighborhood Hits	26
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

RTN1_MOUSE
θ value	2.36792 (rank : 98)	NC score	0.016831 (rank : 291)
Query Neighborhood Hits	143	Target Neighborhood Hits	189	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

TFCP2_HUMAN
θ value	2.36792 (rank : 99)	NC score	0.065177 (rank : 216)
Query Neighborhood Hits	143	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q12800, Q12801, Q9UD77	Gene names	TFCP2, LSF, SEF
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2 (Transcription factor LSF) (SAA3 enhancer factor).

TFCP2_MOUSE
θ value	2.36792 (rank : 100)	NC score	0.065189 (rank : 215)
Query Neighborhood Hits	143	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ERA0, Q3UGJ4, Q8VC13	Gene names	Tcfcp2
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2.

ARHG6_MOUSE
θ value	3.0926 (rank : 101)	NC score	0.172648 (rank : 55)
Query Neighborhood Hits	143	Target Neighborhood Hits	394	Shared Neighborhood Hits	91
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CN155_HUMAN
θ value	3.0926 (rank : 102)	NC score	0.020763 (rank : 286)
Query Neighborhood Hits	143	Target Neighborhood Hits	385	Shared Neighborhood Hits	18
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

M3KL4_HUMAN
θ value	3.0926 (rank : 103)	NC score	0.084696 (rank : 180)
Query Neighborhood Hits	143	Target Neighborhood Hits	1087	Shared Neighborhood Hits	92
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MSPD3_MOUSE
θ value	3.0926 (rank : 104)	NC score	0.017427 (rank : 289)
Query Neighborhood Hits	143	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGG6	Gene names	Mospd3
Domain Architecture	No domain graphic available
Description	Motile sperm domain-containing protein 3.

PRP1_HUMAN
θ value	3.0926 (rank : 105)	NC score	0.015034 (rank : 295)
Query Neighborhood Hits	143	Target Neighborhood Hits	385	Shared Neighborhood Hits	23
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

SET1A_HUMAN
θ value	3.0926 (rank : 106)	NC score	0.017473 (rank : 288)
Query Neighborhood Hits	143	Target Neighborhood Hits	690	Shared Neighborhood Hits	20
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SNPC2_HUMAN
θ value	3.0926 (rank : 107)	NC score	0.021102 (rank : 285)
Query Neighborhood Hits	143	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q13487, Q13486	Gene names	SNAPC2, SNAP45
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE- binding factor subunit delta) (PTF subunit delta).

CDT1_HUMAN
θ value	4.03905 (rank : 108)	NC score	0.016480 (rank : 292)
Query Neighborhood Hits	143	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

PDLI7_HUMAN
θ value	4.03905 (rank : 109)	NC score	0.005846 (rank : 307)
Query Neighborhood Hits	143	Target Neighborhood Hits	547	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SH3G3_MOUSE
θ value	4.03905 (rank : 110)	NC score	0.171191 (rank : 56)
Query Neighborhood Hits	143	Target Neighborhood Hits	236	Shared Neighborhood Hits	91
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ACINU_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.013127 (rank : 296)
Query Neighborhood Hits	143	Target Neighborhood Hits	828	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

FRS2_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.009572 (rank : 301)
Query Neighborhood Hits	143	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

NCF2_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.242098 (rank : 31)
Query Neighborhood Hits	143	Target Neighborhood Hits	229	Shared Neighborhood Hits	80
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G3_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.158793 (rank : 70)
Query Neighborhood Hits	143	Target Neighborhood Hits	222	Shared Neighborhood Hits	87
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

TIA1_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.003189 (rank : 311)
Query Neighborhood Hits	143	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	P31483	Gene names	TIA1
Domain Architecture	No domain graphic available
Description	Nucleolysin TIA-1 isoform p40 (RNA-binding protein TIA-1) (p40-TIA-1) [Contains: Nucleolysin TIA-1 isoform p15 (p15-TIA-1)].

ZIMP7_MOUSE
θ value	5.27518 (rank : 116)	NC score	0.012241 (rank : 298)
Query Neighborhood Hits	143	Target Neighborhood Hits	566	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

CLIC6_MOUSE
θ value	6.88961 (rank : 117)	NC score	0.005464 (rank : 309)
Query Neighborhood Hits	143	Target Neighborhood Hits	134	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

GG12A_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.023314 (rank : 274)
Query Neighborhood Hits	143	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	Q4V321	Gene names	GAGE12A
Domain Architecture	No domain graphic available
Description	G antigen 12A (GAGE-12A).

HTSF1_MOUSE
θ value	6.88961 (rank : 119)	NC score	0.006292 (rank : 306)
Query Neighborhood Hits	143	Target Neighborhood Hits	425	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

K0240_MOUSE
θ value	6.88961 (rank : 120)	NC score	0.009606 (rank : 300)
Query Neighborhood Hits	143	Target Neighborhood Hits	211	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

PACN2_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.164723 (rank : 63)
Query Neighborhood Hits	143	Target Neighborhood Hits	339	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RHG06_MOUSE
θ value	6.88961 (rank : 122)	NC score	0.011750 (rank : 299)
Query Neighborhood Hits	143	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RTN4_MOUSE
θ value	6.88961 (rank : 123)	NC score	0.015773 (rank : 294)
Query Neighborhood Hits	143	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SIPA1_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.007467 (rank : 305)
Query Neighborhood Hits	143	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

STAC3_MOUSE
θ value	6.88961 (rank : 125)	NC score	0.174742 (rank : 51)
Query Neighborhood Hits	143	Target Neighborhood Hits	232	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG4_MOUSE
θ value	8.99809 (rank : 126)	NC score	0.088890 (rank : 174)
Query Neighborhood Hits	143	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BAT3_MOUSE
θ value	8.99809 (rank : 127)	NC score	0.008980 (rank : 303)
Query Neighborhood Hits	143	Target Neighborhood Hits	518	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

CJ095_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.016279 (rank : 293)
Query Neighborhood Hits	143	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H7T3	Gene names	C10orf95
Domain Architecture	No domain graphic available
Description	Protein C10orf95.

DNM3A_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.005533 (rank : 308)
Query Neighborhood Hits	143	Target Neighborhood Hits	91	Shared Neighborhood Hits	3
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

FA43B_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.009535 (rank : 302)
Query Neighborhood Hits	143	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZT52	Gene names	FAM43B
Domain Architecture	No domain graphic available
Description	Protein FAM43B.

GAGE1_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.022566 (rank : 275)
Query Neighborhood Hits	143	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q13065	Gene names	GAGE1
Domain Architecture
Description	G antigen 1 (GAGE-1) (MZ2-F antigen).

GAGE2_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.022345 (rank : 277)
Query Neighborhood Hits	143	Target Neighborhood Hits	50	Shared Neighborhood Hits	12
SwissProt Accessions	Q13066, Q4V322	Gene names	GAGE2
Domain Architecture	No domain graphic available
Description	G antigen 2 (GAGE-2).

GAGE3_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.022105 (rank : 278)
Query Neighborhood Hits	143	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13067	Gene names	GAGE3
Domain Architecture
Description	G antigen 3 (GAGE-3).

GAGE4_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.021922 (rank : 281)
Query Neighborhood Hits	143	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13068, Q6NT33	Gene names	GAGE4
Domain Architecture
Description	G antigen 4 (GAGE-4).

GAGE5_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.021914 (rank : 282)
Query Neighborhood Hits	143	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q13069, Q6FG72	Gene names	GAGE5
Domain Architecture
Description	G antigen 5 (GAGE-5).

GAGE6_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.021891 (rank : 283)
Query Neighborhood Hits	143	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	Q13070	Gene names	GAGE6
Domain Architecture
Description	G antigen 6 (GAGE-6).

GAGE7_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.021884 (rank : 284)
Query Neighborhood Hits	143	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	O76087, Q4V324	Gene names	GAGE7B, GAGE7
Domain Architecture
Description	G antigen 7 (GAGE-7) (GAGE-7B) (GAGE-8) (AL4).

GAGE8_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.022394 (rank : 276)
Query Neighborhood Hits	143	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UEU5, Q4V325	Gene names	GAGE8
Domain Architecture
Description	G antigen 8 (GAGE-8).

MLL3_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.007601 (rank : 304)
Query Neighborhood Hits	143	Target Neighborhood Hits	1644	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

OXRP_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.005365 (rank : 310)
Query Neighborhood Hits	143	Target Neighborhood Hits	544	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

SRGP2_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.099867 (rank : 157)
Query Neighborhood Hits	143	Target Neighborhood Hits	331	Shared Neighborhood Hits	85
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.173273 (rank : 54)
Query Neighborhood Hits	143	Target Neighborhood Hits	228	Shared Neighborhood Hits	82
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV2_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.146311 (rank : 87)
Query Neighborhood Hits	143	Target Neighborhood Hits	453	Shared Neighborhood Hits	91
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

AATK_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.050835 (rank : 262)
Query Neighborhood Hits	143	Target Neighborhood Hits	1243	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.051599 (rank : 258)
Query Neighborhood Hits	143	Target Neighborhood Hits	942	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI1_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.121370 (rank : 126)
Query Neighborhood Hits	143	Target Neighborhood Hits	257	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.128551 (rank : 114)
Query Neighborhood Hits	143	Target Neighborhood Hits	246	Shared Neighborhood Hits	82
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.141937 (rank : 98)
Query Neighborhood Hits	143	Target Neighborhood Hits	350	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.141896 (rank : 99)
Query Neighborhood Hits	143	Target Neighborhood Hits	266	Shared Neighborhood Hits	86
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.124150 (rank : 120)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.129295 (rank : 112)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.091856 (rank : 167)
Query Neighborhood Hits	143	Target Neighborhood Hits	1220	Shared Neighborhood Hits	83
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.091727 (rank : 168)
Query Neighborhood Hits	143	Target Neighborhood Hits	1178	Shared Neighborhood Hits	82
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.095791 (rank : 162)
Query Neighborhood Hits	143	Target Neighborhood Hits	1045	Shared Neighborhood Hits	80
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.057581 (rank : 230)
Query Neighborhood Hits	143	Target Neighborhood Hits	1140	Shared Neighborhood Hits	47
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.059010 (rank : 224)
Query Neighborhood Hits	143	Target Neighborhood Hits	1080	Shared Neighborhood Hits	49
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ALK_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.053402 (rank : 245)
Query Neighborhood Hits	143	Target Neighborhood Hits	795	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.053618 (rank : 244)
Query Neighborhood Hits	143	Target Neighborhood Hits	811	Shared Neighborhood Hits	27
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ANM2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.136824 (rank : 103)
Query Neighborhood Hits	143	Target Neighborhood Hits	175	Shared Neighborhood Hits	83
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.136678 (rank : 104)
Query Neighborhood Hits	143	Target Neighborhood Hits	175	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APS_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.056130 (rank : 234)
Query Neighborhood Hits	143	Target Neighborhood Hits	162	Shared Neighborhood Hits	34
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG4_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.119993 (rank : 132)
Query Neighborhood Hits	143	Target Neighborhood Hits	242	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.149098 (rank : 81)
Query Neighborhood Hits	143	Target Neighborhood Hits	376	Shared Neighborhood Hits	87
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.163146 (rank : 65)
Query Neighborhood Hits	143	Target Neighborhood Hits	347	Shared Neighborhood Hits	90
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG9_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.102979 (rank : 154)
Query Neighborhood Hits	143	Target Neighborhood Hits	235	Shared Neighborhood Hits	77
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.104882 (rank : 152)
Query Neighborhood Hits	143	Target Neighborhood Hits	234	Shared Neighborhood Hits	78
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

BCAR1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.141672 (rank : 100)
Query Neighborhood Hits	143	Target Neighborhood Hits	554	Shared Neighborhood Hits	90
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.144949 (rank : 90)
Query Neighborhood Hits	143	Target Neighborhood Hits	438	Shared Neighborhood Hits	88
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BMX_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.069112 (rank : 206)
Query Neighborhood Hits	143	Target Neighborhood Hits	942	Shared Neighborhood Hits	37
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.069559 (rank : 204)
Query Neighborhood Hits	143	Target Neighborhood Hits	912	Shared Neighborhood Hits	37
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CASL_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.116025 (rank : 136)
Query Neighborhood Hits	143	Target Neighborhood Hits	259	Shared Neighborhood Hits	77
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.111944 (rank : 141)
Query Neighborhood Hits	143	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.196311 (rank : 39)
Query Neighborhood Hits	143	Target Neighborhood Hits	315	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.212589 (rank : 38)
Query Neighborhood Hits	143	Target Neighborhood Hits	336	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CSK_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.090200 (rank : 172)
Query Neighborhood Hits	143	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.090215 (rank : 171)
Query Neighborhood Hits	143	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.114166 (rank : 138)
Query Neighborhood Hits	143	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.085999 (rank : 176)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.085078 (rank : 179)
Query Neighborhood Hits	143	Target Neighborhood Hits	225	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.131474 (rank : 109)
Query Neighborhood Hits	143	Target Neighborhood Hits	244	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.131742 (rank : 108)
Query Neighborhood Hits	143	Target Neighborhood Hits	306	Shared Neighborhood Hits	79
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.078951 (rank : 186)
Query Neighborhood Hits	143	Target Neighborhood Hits	592	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.078400 (rank : 188)
Query Neighborhood Hits	143	Target Neighborhood Hits	599	Shared Neighborhood Hits	75
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.074458 (rank : 196)
Query Neighborhood Hits	143	Target Neighborhood Hits	625	Shared Neighborhood Hits	69
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDR1_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.050622 (rank : 265)
Query Neighborhood Hits	143	Target Neighborhood Hits	819	Shared Neighborhood Hits	26
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.050817 (rank : 263)
Query Neighborhood Hits	143	Target Neighborhood Hits	818	Shared Neighborhood Hits	26
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

EPHAA_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.050848 (rank : 261)
Query Neighborhood Hits	143	Target Neighborhood Hits	960	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.050184 (rank : 270)
Query Neighborhood Hits	143	Target Neighborhood Hits	912	Shared Neighborhood Hits	26
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.050282 (rank : 269)
Query Neighborhood Hits	143	Target Neighborhood Hits	1073	Shared Neighborhood Hits	33
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

FAK2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.050592 (rank : 266)
Query Neighborhood Hits	143	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.050359 (rank : 268)
Query Neighborhood Hits	143	Target Neighborhood Hits	851	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FER_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.063084 (rank : 220)
Query Neighborhood Hits	143	Target Neighborhood Hits	1278	Shared Neighborhood Hits	52
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.054363 (rank : 239)
Query Neighborhood Hits	143	Target Neighborhood Hits	978	Shared Neighborhood Hits	37
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.053359 (rank : 246)
Query Neighborhood Hits	143	Target Neighborhood Hits	980	Shared Neighborhood Hits	36
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.111736 (rank : 142)
Query Neighborhood Hits	143	Target Neighborhood Hits	1067	Shared Neighborhood Hits	90
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FNBP2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.104684 (rank : 153)
Query Neighborhood Hits	143	Target Neighborhood Hits	432	Shared Neighborhood Hits	80
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRB10_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.050515 (rank : 267)
Query Neighborhood Hits	143	Target Neighborhood Hits	156	Shared Neighborhood Hits	36
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.068621 (rank : 208)
Query Neighborhood Hits	143	Target Neighborhood Hits	137	Shared Neighborhood Hits	36
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.070259 (rank : 202)
Query Neighborhood Hits	143	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.053645 (rank : 243)
Query Neighborhood Hits	143	Target Neighborhood Hits	156	Shared Neighborhood Hits	38
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.058576 (rank : 225)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HCLS1_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.142131 (rank : 97)
Query Neighborhood Hits	143	Target Neighborhood Hits	358	Shared Neighborhood Hits	88
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.144568 (rank : 91)
Query Neighborhood Hits	143	Target Neighborhood Hits	329	Shared Neighborhood Hits	91
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HSH2D_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.068222 (rank : 209)
Query Neighborhood Hits	143	Target Neighborhood Hits	159	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

KSYK_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.055775 (rank : 235)
Query Neighborhood Hits	143	Target Neighborhood Hits	901	Shared Neighborhood Hits	41
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.056483 (rank : 233)
Query Neighborhood Hits	143	Target Neighborhood Hits	944	Shared Neighborhood Hits	43
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LASP1_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.105537 (rank : 149)
Query Neighborhood Hits	143	Target Neighborhood Hits	293	Shared Neighborhood Hits	74
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.104902 (rank : 151)
Query Neighborhood Hits	143	Target Neighborhood Hits	297	Shared Neighborhood Hits	74
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LCP2_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.051721 (rank : 257)
Query Neighborhood Hits	143	Target Neighborhood Hits	531	Shared Neighborhood Hits	40
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.058082 (rank : 228)
Query Neighborhood Hits	143	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.051562 (rank : 259)
Query Neighborhood Hits	143	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LTK_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.054090 (rank : 241)
Query Neighborhood Hits	143	Target Neighborhood Hits	774	Shared Neighborhood Hits	26
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.054112 (rank : 240)
Query Neighborhood Hits	143	Target Neighborhood Hits	770	Shared Neighborhood Hits	27
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LYN_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.106413 (rank : 148)
Query Neighborhood Hits	143	Target Neighborhood Hits	1022	Shared Neighborhood Hits	89
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.107093 (rank : 145)
Query Neighborhood Hits	143	Target Neighborhood Hits	1023	Shared Neighborhood Hits	88
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.072138 (rank : 200)
Query Neighborhood Hits	143	Target Neighborhood Hits	1071	Shared Neighborhood Hits	86
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.066955 (rank : 212)
Query Neighborhood Hits	143	Target Neighborhood Hits	1136	Shared Neighborhood Hits	87
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.069675 (rank : 203)
Query Neighborhood Hits	143	Target Neighborhood Hits	1123	Shared Neighborhood Hits	89
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MATK_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.066991 (rank : 211)
Query Neighborhood Hits	143	Target Neighborhood Hits	954	Shared Neighborhood Hits	48
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.067248 (rank : 210)
Query Neighborhood Hits	143	Target Neighborhood Hits	952	Shared Neighborhood Hits	52
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

NCF4_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.126731 (rank : 117)
Query Neighborhood Hits	143	Target Neighborhood Hits	161	Shared Neighborhood Hits	64
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.143175 (rank : 94)
Query Neighborhood Hits	143	Target Neighborhood Hits	177	Shared Neighborhood Hits	72
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.091146 (rank : 169)
Query Neighborhood Hits	143	Target Neighborhood Hits	457	Shared Neighborhood Hits	74
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.082813 (rank : 181)
Query Neighborhood Hits	143	Target Neighborhood Hits	420	Shared Neighborhood Hits	76
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.055671 (rank : 236)
Query Neighborhood Hits	143	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.052891 (rank : 248)
Query Neighborhood Hits	143	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.106904 (rank : 146)
Query Neighborhood Hits	143	Target Neighborhood Hits	100	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.115246 (rank : 137)
Query Neighborhood Hits	143	Target Neighborhood Hits	114	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

OSTF1_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.162485 (rank : 67)
Query Neighborhood Hits	143	Target Neighborhood Hits	466	Shared Neighborhood Hits	91
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.153587 (rank : 77)
Query Neighborhood Hits	143	Target Neighborhood Hits	467	Shared Neighborhood Hits	91
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.074407 (rank : 197)
Query Neighborhood Hits	143	Target Neighborhood Hits	451	Shared Neighborhood Hits	47
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.072096 (rank : 201)
Query Neighborhood Hits	143	Target Neighborhood Hits	401	Shared Neighborhood Hits	45
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.077196 (rank : 193)
Query Neighborhood Hits	143	Target Neighborhood Hits	479	Shared Neighborhood Hits	62
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.078503 (rank : 187)
Query Neighborhood Hits	143	Target Neighborhood Hits	435	Shared Neighborhood Hits	65
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.077248 (rank : 192)
Query Neighborhood Hits	143	Target Neighborhood Hits	543	Shared Neighborhood Hits	55
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.077799 (rank : 190)
Query Neighborhood Hits	143	Target Neighborhood Hits	519	Shared Neighborhood Hits	55
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.162725 (rank : 66)
Query Neighborhood Hits	143	Target Neighborhood Hits	320	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.156823 (rank : 72)
Query Neighborhood Hits	143	Target Neighborhood Hits	283	Shared Neighborhood Hits	87
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN3_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.145060 (rank : 89)
Query Neighborhood Hits	143	Target Neighborhood Hits	385	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.142857 (rank : 96)
Query Neighborhood Hits	143	Target Neighborhood Hits	380	Shared Neighborhood Hits	84
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.093268 (rank : 166)
Query Neighborhood Hits	143	Target Neighborhood Hits	128	Shared Neighborhood Hits	55
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.094945 (rank : 163)
Query Neighborhood Hits	143	Target Neighborhood Hits	126	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PLCG1_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.128315 (rank : 115)
Query Neighborhood Hits	143	Target Neighborhood Hits	293	Shared Neighborhood Hits	82
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.130996 (rank : 110)
Query Neighborhood Hits	143	Target Neighborhood Hits	314	Shared Neighborhood Hits	84
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.134846 (rank : 105)
Query Neighborhood Hits	143	Target Neighborhood Hits	280	Shared Neighborhood Hits	84
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PTN11_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.052450 (rank : 253)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.052457 (rank : 252)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

RASA1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.093837 (rank : 164)
Query Neighborhood Hits	143	Target Neighborhood Hits	258	Shared Neighborhood Hits	45
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG26_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.060052 (rank : 223)
Query Neighborhood Hits	143	Target Neighborhood Hits	281	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.053655 (rank : 242)
Query Neighborhood Hits	143	Target Neighborhood Hits	1376	Shared Neighborhood Hits	81
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.081448 (rank : 183)
Query Neighborhood Hits	143	Target Neighborhood Hits	263	Shared Neighborhood Hits	59
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.077504 (rank : 191)
Query Neighborhood Hits	143	Target Neighborhood Hits	246	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ROS_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.052464 (rank : 251)
Query Neighborhood Hits	143	Target Neighborhood Hits	907	Shared Neighborhood Hits	26
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUSC1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.113675 (rank : 139)
Query Neighborhood Hits	143	Target Neighborhood Hits	226	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.082115 (rank : 182)
Query Neighborhood Hits	143	Target Neighborhood Hits	206	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RYK_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.052877 (rank : 249)
Query Neighborhood Hits	143	Target Neighborhood Hits	701	Shared Neighborhood Hits	26
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.052416 (rank : 254)
Query Neighborhood Hits	143	Target Neighborhood Hits	715	Shared Neighborhood Hits	26
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SH21A_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.073774 (rank : 198)
Query Neighborhood Hits	143	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.080483 (rank : 184)
Query Neighborhood Hits	143	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.093722 (rank : 165)
Query Neighborhood Hits	143	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.095996 (rank : 161)
Query Neighborhood Hits	143	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH24A_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.051800 (rank : 256)
Query Neighborhood Hits	143	Target Neighborhood Hits	455	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH2D3_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.051296 (rank : 260)
Query Neighborhood Hits	143	Target Neighborhood Hits	174	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3G1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.147417 (rank : 82)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	88
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.149618 (rank : 78)
Query Neighborhood Hits	143	Target Neighborhood Hits	291	Shared Neighborhood Hits	91
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.153637 (rank : 76)
Query Neighborhood Hits	143	Target Neighborhood Hits	324	Shared Neighborhood Hits	91
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.155609 (rank : 73)
Query Neighborhood Hits	143	Target Neighborhood Hits	319	Shared Neighborhood Hits	90
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3K1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.189749 (rank : 45)
Query Neighborhood Hits	143	Target Neighborhood Hits	341	Shared Neighborhood Hits	92
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.191599 (rank : 43)
Query Neighborhood Hits	143	Target Neighborhood Hits	332	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHB_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.066047 (rank : 213)
Query Neighborhood Hits	143	Target Neighborhood Hits	141	Shared Neighborhood Hits	37
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.069070 (rank : 207)
Query Neighborhood Hits	143	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.063339 (rank : 219)
Query Neighborhood Hits	143	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.062686 (rank : 221)
Query Neighborhood Hits	143	Target Neighborhood Hits	180	Shared Neighborhood Hits	39
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.063564 (rank : 218)
Query Neighborhood Hits	143	Target Neighborhood Hits	170	Shared Neighborhood Hits	41
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.064051 (rank : 217)
Query Neighborhood Hits	143	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.057923 (rank : 229)
Query Neighborhood Hits	143	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.065421 (rank : 214)
Query Neighborhood Hits	143	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.058558 (rank : 226)
Query Neighborhood Hits	143	Target Neighborhood Hits	204	Shared Neighborhood Hits	35
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.061074 (rank : 222)
Query Neighborhood Hits	143	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.072396 (rank : 199)
Query Neighborhood Hits	143	Target Neighborhood Hits	164	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.074484 (rank : 195)
Query Neighborhood Hits	143	Target Neighborhood Hits	169	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.078387 (rank : 189)
Query Neighborhood Hits	143	Target Neighborhood Hits	96	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.079755 (rank : 185)
Query Neighborhood Hits	143	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.089940 (rank : 173)
Query Neighborhood Hits	143	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.090879 (rank : 170)
Query Neighborhood Hits	143	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.146070 (rank : 88)
Query Neighborhood Hits	143	Target Neighborhood Hits	113	Shared Neighborhood Hits	40
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.143074 (rank : 95)
Query Neighborhood Hits	143	Target Neighborhood Hits	117	Shared Neighborhood Hits	39
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.155339 (rank : 74)
Query Neighborhood Hits	143	Target Neighborhood Hits	139	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.155317 (rank : 75)
Query Neighborhood Hits	143	Target Neighborhood Hits	136	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SNX9_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.069501 (rank : 205)
Query Neighborhood Hits	143	Target Neighborhood Hits	148	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.075039 (rank : 194)
Query Neighborhood Hits	143	Target Neighborhood Hits	141	Shared Neighborhood Hits	45
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.147230 (rank : 83)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.132438 (rank : 106)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.183265 (rank : 47)
Query Neighborhood Hits	143	Target Neighborhood Hits	396	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.191724 (rank : 42)
Query Neighborhood Hits	143	Target Neighborhood Hits	409	Shared Neighborhood Hits	92
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.149550 (rank : 80)
Query Neighborhood Hits	143	Target Neighborhood Hits	269	Shared Neighborhood Hits	89
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.143675 (rank : 92)
Query Neighborhood Hits	143	Target Neighborhood Hits	292	Shared Neighborhood Hits	92
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.098224 (rank : 160)
Query Neighborhood Hits	143	Target Neighborhood Hits	390	Shared Neighborhood Hits	81
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.099333 (rank : 159)
Query Neighborhood Hits	143	Target Neighborhood Hits	324	Shared Neighborhood Hits	84
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.085157 (rank : 178)
Query Neighborhood Hits	143	Target Neighborhood Hits	946	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.086090 (rank : 175)
Query Neighborhood Hits	143	Target Neighborhood Hits	964	Shared Neighborhood Hits	63
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STAC_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.191184 (rank : 44)
Query Neighborhood Hits	143	Target Neighborhood Hits	276	Shared Neighborhood Hits	92
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.164087 (rank : 64)
Query Neighborhood Hits	143	Target Neighborhood Hits	268	Shared Neighborhood Hits	87
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STYK1_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.052515 (rank : 250)
Query Neighborhood Hits	143	Target Neighborhood Hits	786	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.052210 (rank : 255)
Query Neighborhood Hits	143	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TCGAP_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.057287 (rank : 231)
Query Neighborhood Hits	143	Target Neighborhood Hits	409	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TNK1_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.050654 (rank : 264)
Query Neighborhood Hits	143	Target Neighborhood Hits	815	Shared Neighborhood Hits	28
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

VAV2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.146326 (rank : 86)
Query Neighborhood Hits	143	Target Neighborhood Hits	456	Shared Neighborhood Hits	91
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.157986 (rank : 71)
Query Neighborhood Hits	143	Target Neighborhood Hits	398	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.149588 (rank : 79)
Query Neighborhood Hits	143	Target Neighborhood Hits	404	Shared Neighborhood Hits	91
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ZAP70_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.057280 (rank : 232)
Query Neighborhood Hits	143	Target Neighborhood Hits	893	Shared Neighborhood Hits	42
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.058406 (rank : 227)
Query Neighborhood Hits	143	Target Neighborhood Hits	905	Shared Neighborhood Hits	41
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

ES8L1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	143	Target Neighborhood Hits	143	Shared Neighborhood Hits	143
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_HUMAN
NC score	0.983195 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	143	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_MOUSE
NC score	0.933261 (rank : 3)	θ value	3.4095e-124 (rank : 3)
Query Neighborhood Hits	143	Target Neighborhood Hits	169	Shared Neighborhood Hits	86
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_MOUSE
NC score	0.932280 (rank : 4)	θ value	6.228e-118 (rank : 5)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	80
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L2_HUMAN
NC score	0.926571 (rank : 5)	θ value	6.65404e-120 (rank : 4)
Query Neighborhood Hits	143	Target Neighborhood Hits	193	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_HUMAN
NC score	0.926461 (rank : 6)	θ value	9.30652e-114 (rank : 6)
Query Neighborhood Hits	143	Target Neighborhood Hits	151	Shared Neighborhood Hits	76
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L3_MOUSE
NC score	0.889122 (rank : 7)	θ value	2.32979e-56 (rank : 8)
Query Neighborhood Hits	143	Target Neighborhood Hits	168	Shared Neighborhood Hits	91
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_HUMAN
NC score	0.877954 (rank : 8)	θ value	1.41016e-61 (rank : 7)
Query Neighborhood Hits	143	Target Neighborhood Hits	206	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NCK2_HUMAN
NC score	0.373109 (rank : 9)	θ value	3.19293e-05 (rank : 12)
Query Neighborhood Hits	143	Target Neighborhood Hits	310	Shared Neighborhood Hits	98
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.359922 (rank : 10)	θ value	7.1131e-05 (rank : 15)
Query Neighborhood Hits	143	Target Neighborhood Hits	312	Shared Neighborhood Hits	95
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NPHP1_MOUSE
NC score	0.327458 (rank : 11)	θ value	0.00509761 (rank : 39)
Query Neighborhood Hits	143	Target Neighborhood Hits	267	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NPHP1_HUMAN
NC score	0.325557 (rank : 12)	θ value	9.29e-05 (rank : 17)
Query Neighborhood Hits	143	Target Neighborhood Hits	288	Shared Neighborhood Hits	91
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

STAM2_MOUSE
NC score	0.319461 (rank : 13)	θ value	4.45536e-07 (rank : 9)
Query Neighborhood Hits	143	Target Neighborhood Hits	285	Shared Neighborhood Hits	94
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CRKL_HUMAN
NC score	0.316602 (rank : 14)	θ value	0.21417 (rank : 76)
Query Neighborhood Hits	143	Target Neighborhood Hits	313	Shared Neighborhood Hits	95
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAM2_HUMAN
NC score	0.315517 (rank : 15)	θ value	2.21117e-06 (rank : 10)
Query Neighborhood Hits	143	Target Neighborhood Hits	288	Shared Neighborhood Hits	95
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CRKL_MOUSE
NC score	0.314683 (rank : 16)	θ value	0.163984 (rank : 71)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

GRAP2_MOUSE
NC score	0.304758 (rank : 17)	θ value	0.00102713 (rank : 29)
Query Neighborhood Hits	143	Target Neighborhood Hits	297	Shared Neighborhood Hits	96
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAM1_MOUSE
NC score	0.304722 (rank : 18)	θ value	8.40245e-06 (rank : 11)
Query Neighborhood Hits	143	Target Neighborhood Hits	273	Shared Neighborhood Hits	93
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP2_HUMAN
NC score	0.303398 (rank : 19)	θ value	0.0113563 (rank : 40)
Query Neighborhood Hits	143	Target Neighborhood Hits	304	Shared Neighborhood Hits	96
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

STAM1_HUMAN
NC score	0.294599 (rank : 20)	θ value	0.000786445 (rank : 28)
Query Neighborhood Hits	143	Target Neighborhood Hits	271	Shared Neighborhood Hits	92
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CRK_MOUSE
NC score	0.293299 (rank : 21)	θ value	0.000461057 (rank : 24)
Query Neighborhood Hits	143	Target Neighborhood Hits	314	Shared Neighborhood Hits	93
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PPIP1_HUMAN
NC score	0.292280 (rank : 22)	θ value	0.0193708 (rank : 45)
Query Neighborhood Hits	143	Target Neighborhood Hits	389	Shared Neighborhood Hits	94
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP_HUMAN
NC score	0.288950 (rank : 23)	θ value	0.0330416 (rank : 52)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	97
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CRK_HUMAN
NC score	0.288823 (rank : 24)	θ value	0.0330416 (rank : 50)
Query Neighborhood Hits	143	Target Neighborhood Hits	308	Shared Neighborhood Hits	94
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRB2_HUMAN
NC score	0.286067 (rank : 25)	θ value	0.00228821 (rank : 33)
Query Neighborhood Hits	143	Target Neighborhood Hits	310	Shared Neighborhood Hits	97
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.284986 (rank : 26)	θ value	0.00228821 (rank : 34)
Query Neighborhood Hits	143	Target Neighborhood Hits	312	Shared Neighborhood Hits	97
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PPIP1_MOUSE
NC score	0.279748 (rank : 27)	θ value	0.0330416 (rank : 53)
Query Neighborhood Hits	143	Target Neighborhood Hits	377	Shared Neighborhood Hits	93
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

GRAP_MOUSE
NC score	0.278526 (rank : 28)	θ value	0.0193708 (rank : 44)
Query Neighborhood Hits	143	Target Neighborhood Hits	309	Shared Neighborhood Hits	95
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VINEX_MOUSE
NC score	0.273735 (rank : 29)	θ value	0.00020696 (rank : 21)
Query Neighborhood Hits	143	Target Neighborhood Hits	286	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.248651 (rank : 30)	θ value	0.00102713 (rank : 31)
Query Neighborhood Hits	143	Target Neighborhood Hits	270	Shared Neighborhood Hits	93
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCF2_HUMAN
NC score	0.242098 (rank : 31)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	143	Target Neighborhood Hits	229	Shared Neighborhood Hits	80
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF1_HUMAN
NC score	0.239045 (rank : 32)	θ value	0.125558 (rank : 67)
Query Neighborhood Hits	143	Target Neighborhood Hits	198	Shared Neighborhood Hits	85
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

DNMBP_HUMAN
NC score	0.235007 (rank : 33)	θ value	0.0736092 (rank : 61)
Query Neighborhood Hits	143	Target Neighborhood Hits	413	Shared Neighborhood Hits	98
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

AHI1_HUMAN
NC score	0.229017 (rank : 34)	θ value	0.00035302 (rank : 23)
Query Neighborhood Hits	143	Target Neighborhood Hits	537	Shared Neighborhood Hits	97
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

NCF1_MOUSE
NC score	0.217181 (rank : 35)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	143	Target Neighborhood Hits	198	Shared Neighborhood Hits	86
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

AHI1_MOUSE
NC score	0.217013 (rank : 36)	θ value	0.0148317 (rank : 41)
Query Neighborhood Hits	143	Target Neighborhood Hits	496	Shared Neighborhood Hits	97
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

DNMBP_MOUSE
NC score	0.216898 (rank : 37)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	143	Target Neighborhood Hits	435	Shared Neighborhood Hits	100
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CD2AP_MOUSE
NC score	0.212589 (rank : 38)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	143	Target Neighborhood Hits	336	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.196311 (rank : 39)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	143	Target Neighborhood Hits	315	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

VAV_HUMAN
NC score	0.195815 (rank : 40)	θ value	0.0330416 (rank : 55)
Query Neighborhood Hits	143	Target Neighborhood Hits	452	Shared Neighborhood Hits	94
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.192849 (rank : 41)	θ value	0.0961366 (rank : 63)
Query Neighborhood Hits	143	Target Neighborhood Hits	430	Shared Neighborhood Hits	94
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SRBS1_MOUSE
NC score	0.191724 (rank : 42)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	143	Target Neighborhood Hits	409	Shared Neighborhood Hits	92
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3K1_MOUSE
NC score	0.191599 (rank : 43)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	143	Target Neighborhood Hits	332	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STAC_HUMAN
NC score	0.191184 (rank : 44)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	143	Target Neighborhood Hits	276	Shared Neighborhood Hits	92
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH3K1_HUMAN
NC score	0.189749 (rank : 45)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	143	Target Neighborhood Hits	341	Shared Neighborhood Hits	92
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

EFS_MOUSE
NC score	0.186512 (rank : 46)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	143	Target Neighborhood Hits	389	Shared Neighborhood Hits	83
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SRBS1_HUMAN
NC score	0.183265 (rank : 47)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	143	Target Neighborhood Hits	396	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ITSN2_HUMAN
NC score	0.181740 (rank : 48)	θ value	0.000270298 (rank : 22)
Query Neighborhood Hits	143	Target Neighborhood Hits	1173	Shared Neighborhood Hits	99
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHG7_MOUSE
NC score	0.179719 (rank : 49)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	143	Target Neighborhood Hits	396	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ITSN1_MOUSE
NC score	0.175755 (rank : 50)	θ value	0.00298849 (rank : 36)
Query Neighborhood Hits	143	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

STAC3_MOUSE
NC score	0.174742 (rank : 51)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	143	Target Neighborhood Hits	232	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SPTA1_MOUSE
NC score	0.174695 (rank : 52)	θ value	0.00020696 (rank : 19)
Query Neighborhood Hits	143	Target Neighborhood Hits	675	Shared Neighborhood Hits	94
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PACN2_MOUSE
NC score	0.174109 (rank : 53)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	143	Target Neighborhood Hits	382	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

STAC3_HUMAN
NC score	0.173273 (rank : 54)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	143	Target Neighborhood Hits	228	Shared Neighborhood Hits	82
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG6_MOUSE
NC score	0.172648 (rank : 55)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	143	Target Neighborhood Hits	394	Shared Neighborhood Hits	91
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SH3G3_MOUSE
NC score	0.171191 (rank : 56)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	143	Target Neighborhood Hits	236	Shared Neighborhood Hits	91
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SNX18_MOUSE
NC score	0.171150 (rank : 57)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	143	Target Neighborhood Hits	198	Shared Neighborhood Hits	66
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ASPP1_HUMAN
NC score	0.171109 (rank : 58)	θ value	0.0330416 (rank : 49)
Query Neighborhood Hits	143	Target Neighborhood Hits	956	Shared Neighborhood Hits	84
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ITSN1_HUMAN
NC score	0.170393 (rank : 59)	θ value	0.000602161 (rank : 25)
Query Neighborhood Hits	143	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

EFS_HUMAN
NC score	0.170050 (rank : 60)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	143	Target Neighborhood Hits	348	Shared Neighborhood Hits	83
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

CIP4_HUMAN
NC score	0.169697 (rank : 61)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	143	Target Neighborhood Hits	374	Shared Neighborhood Hits	59
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

ITSN2_MOUSE
NC score	0.169675 (rank : 62)	θ value	0.00390308 (rank : 38)
Query Neighborhood Hits	143	Target Neighborhood Hits	1371	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PACN2_HUMAN
NC score	0.164723 (rank : 63)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	143	Target Neighborhood Hits	339	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

STAC_MOUSE
NC score	0.164087 (rank : 64)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	143	Target Neighborhood Hits	268	Shared Neighborhood Hits	87
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_HUMAN
NC score	0.163146 (rank : 65)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	143	Target Neighborhood Hits	347	Shared Neighborhood Hits	90
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PACN1_HUMAN
NC score	0.162725 (rank : 66)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	143	Target Neighborhood Hits	320	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

OSTF1_HUMAN
NC score	0.162485 (rank : 67)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	143	Target Neighborhood Hits	466	Shared Neighborhood Hits	91
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SNX18_HUMAN
NC score	0.162008 (rank : 68)	θ value	1.38821 (rank : 92)
Query Neighborhood Hits	143	Target Neighborhood Hits	207	Shared Neighborhood Hits	66
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ASPP1_MOUSE
NC score	0.161612 (rank : 69)	θ value	0.0431538 (rank : 56)
Query Neighborhood Hits	143	Target Neighborhood Hits	1244	Shared Neighborhood Hits	94
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SH3G3_HUMAN
NC score	0.158793 (rank : 70)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	143	Target Neighborhood Hits	222	Shared Neighborhood Hits	87
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

VAV3_HUMAN
NC score	0.157986 (rank : 71)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	143	Target Neighborhood Hits	398	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PACN1_MOUSE
NC score	0.156823 (rank : 72)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	143	Target Neighborhood Hits	283	Shared Neighborhood Hits	87
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SH3G2_MOUSE
NC score	0.155609 (rank : 73)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	143	Target Neighborhood Hits	319	Shared Neighborhood Hits	90
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SLAP2_HUMAN
NC score	0.155339 (rank : 74)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	143	Target Neighborhood Hits	139	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
NC score	0.155317 (rank : 75)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	143	Target Neighborhood Hits	136	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SH3G2_HUMAN
NC score	0.153637 (rank : 76)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	143	Target Neighborhood Hits	324	Shared Neighborhood Hits	91
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

OSTF1_MOUSE
NC score	0.153587 (rank : 77)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	143	Target Neighborhood Hits	467	Shared Neighborhood Hits	91
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SH3G1_MOUSE
NC score	0.149618 (rank : 78)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	143	Target Neighborhood Hits	291	Shared Neighborhood Hits	91
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

VAV3_MOUSE
NC score	0.149588 (rank : 79)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	143	Target Neighborhood Hits	404	Shared Neighborhood Hits	91
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SRC8_HUMAN
NC score	0.149550 (rank : 80)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	143	Target Neighborhood Hits	269	Shared Neighborhood Hits	89
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ARHG6_HUMAN
NC score	0.149098 (rank : 81)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	143	Target Neighborhood Hits	376	Shared Neighborhood Hits	87
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SH3G1_HUMAN
NC score	0.147417 (rank : 82)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	88
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SPN90_HUMAN
NC score	0.147230 (rank : 83)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPTA1_HUMAN
NC score	0.146947 (rank : 84)	θ value	0.000602161 (rank : 26)
Query Neighborhood Hits	143	Target Neighborhood Hits	748	Shared Neighborhood Hits	90
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

IASPP_HUMAN
NC score	0.146917 (rank : 85)	θ value	0.125558 (rank : 64)
Query Neighborhood Hits	143	Target Neighborhood Hits	688	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

VAV2_MOUSE
NC score	0.146326 (rank : 86)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	143	Target Neighborhood Hits	456	Shared Neighborhood Hits	91
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.146311 (rank : 87)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	143	Target Neighborhood Hits	453	Shared Neighborhood Hits	91
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SLAP1_HUMAN
NC score	0.146070 (rank : 88)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	143	Target Neighborhood Hits	113	Shared Neighborhood Hits	40
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

PACN3_HUMAN
NC score	0.145060 (rank : 89)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	143	Target Neighborhood Hits	385	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

BCAR1_MOUSE
NC score	0.144949 (rank : 90)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	143	Target Neighborhood Hits	438	Shared Neighborhood Hits	88
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

HCLS1_MOUSE
NC score	0.144568 (rank : 91)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	143	Target Neighborhood Hits	329	Shared Neighborhood Hits	91
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_MOUSE
NC score	0.143675 (rank : 92)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	143	Target Neighborhood Hits	292	Shared Neighborhood Hits	92
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SPTA2_HUMAN
NC score	0.143437 (rank : 93)	θ value	0.00298849 (rank : 37)
Query Neighborhood Hits	143	Target Neighborhood Hits	888	Shared Neighborhood Hits	96
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

NCF4_MOUSE
NC score	0.143175 (rank : 94)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	143	Target Neighborhood Hits	177	Shared Neighborhood Hits	72
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SLAP1_MOUSE
NC score	0.143074 (rank : 95)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	143	Target Neighborhood Hits	117	Shared Neighborhood Hits	39
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

PACN3_MOUSE
NC score	0.142857 (rank : 96)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	143	Target Neighborhood Hits	380	Shared Neighborhood Hits	84
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

HCLS1_HUMAN
NC score	0.142131 (rank : 97)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	143	Target Neighborhood Hits	358	Shared Neighborhood Hits	88
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI2_HUMAN
NC score	0.141937 (rank : 98)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	143	Target Neighborhood Hits	350	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.141896 (rank : 99)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	143	Target Neighborhood Hits	266	Shared Neighborhood Hits	86
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

BCAR1_HUMAN
NC score	0.141672 (rank : 100)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	143	Target Neighborhood Hits	554	Shared Neighborhood Hits	90
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BTK_HUMAN
NC score	0.141618 (rank : 101)	θ value	5.44631e-05 (rank : 13)
Query Neighborhood Hits	143	Target Neighborhood Hits	1026	Shared Neighborhood Hits	96
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.141160 (rank : 102)	θ value	5.44631e-05 (rank : 14)
Query Neighborhood Hits	143	Target Neighborhood Hits	1017	Shared Neighborhood Hits	91
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ANM2_HUMAN
NC score	0.136824 (rank : 103)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	143	Target Neighborhood Hits	175	Shared Neighborhood Hits	83
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
NC score	0.136678 (rank : 104)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	143	Target Neighborhood Hits	175	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PLCG2_HUMAN
NC score	0.134846 (rank : 105)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	143	Target Neighborhood Hits	280	Shared Neighborhood Hits	84
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SPN90_MOUSE
NC score	0.132438 (rank : 106)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

IASPP_MOUSE
NC score	0.132198 (rank : 107)	θ value	0.125558 (rank : 65)
Query Neighborhood Hits	143	Target Neighborhood Hits	1024	Shared Neighborhood Hits	93
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DBNL_MOUSE
NC score	0.131742 (rank : 108)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	143	Target Neighborhood Hits	306	Shared Neighborhood Hits	79
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DBNL_HUMAN
NC score	0.131474 (rank : 109)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	143	Target Neighborhood Hits	244	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PLCG1_MOUSE
NC score	0.130996 (rank : 110)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	143	Target Neighborhood Hits	314	Shared Neighborhood Hits	84
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RHG04_HUMAN
NC score	0.130989 (rank : 111)	θ value	0.000158464 (rank : 18)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ABI3_MOUSE
NC score	0.129295 (rank : 112)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BLK_MOUSE
NC score	0.129018 (rank : 113)	θ value	0.00175202 (rank : 32)
Query Neighborhood Hits	143	Target Neighborhood Hits	992	Shared Neighborhood Hits	82
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ABI1_MOUSE
NC score	0.128551 (rank : 114)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	143	Target Neighborhood Hits	246	Shared Neighborhood Hits	82
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PLCG1_HUMAN
NC score	0.128315 (rank : 115)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	143	Target Neighborhood Hits	293	Shared Neighborhood Hits	82
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

HCK_HUMAN
NC score	0.127598 (rank : 116)	θ value	0.0148317 (rank : 42)
Query Neighborhood Hits	143	Target Neighborhood Hits	1035	Shared Neighborhood Hits	94
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

NCF4_HUMAN
NC score	0.126731 (rank : 117)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	143	Target Neighborhood Hits	161	Shared Neighborhood Hits	64
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

BLK_HUMAN
NC score	0.125645 (rank : 118)	θ value	0.0252991 (rank : 48)
Query Neighborhood Hits	143	Target Neighborhood Hits	994	Shared Neighborhood Hits	83
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_MOUSE
NC score	0.125052 (rank : 119)	θ value	0.0148317 (rank : 43)
Query Neighborhood Hits	143	Target Neighborhood Hits	1029	Shared Neighborhood Hits	94
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ABI3_HUMAN
NC score	0.124150 (rank : 120)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

YES_MOUSE
NC score	0.123431 (rank : 121)	θ value	0.0563607 (rank : 60)
Query Neighborhood Hits	143	Target Neighborhood Hits	1052	Shared Neighborhood Hits	95
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.123191 (rank : 122)	θ value	0.0563607 (rank : 59)
Query Neighborhood Hits	143	Target Neighborhood Hits	1059	Shared Neighborhood Hits	95
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.122903 (rank : 123)	θ value	0.163984 (rank : 74)
Query Neighborhood Hits	143	Target Neighborhood Hits	1073	Shared Neighborhood Hits	95
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

TEC_HUMAN
NC score	0.122013 (rank : 124)	θ value	7.1131e-05 (rank : 16)
Query Neighborhood Hits	143	Target Neighborhood Hits	1006	Shared Neighborhood Hits	86
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

FGR_MOUSE
NC score	0.121627 (rank : 125)	θ value	0.0330416 (rank : 51)
Query Neighborhood Hits	143	Target Neighborhood Hits	1069	Shared Neighborhood Hits	94
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ABI1_HUMAN
NC score	0.121370 (rank : 126)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	143	Target Neighborhood Hits	257	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ITK_HUMAN
NC score	0.121367 (rank : 127)	θ value	0.000786445 (rank : 27)
Query Neighborhood Hits	143	Target Neighborhood Hits	1016	Shared Neighborhood Hits	86
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TEC_MOUSE
NC score	0.121250 (rank : 128)	θ value	0.00020696 (rank : 20)
Query Neighborhood Hits	143	Target Neighborhood Hits	1006	Shared Neighborhood Hits	83
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

FYN_HUMAN
NC score	0.120965 (rank : 129)	θ value	0.163984 (rank : 73)
Query Neighborhood Hits	143	Target Neighborhood Hits	1078	Shared Neighborhood Hits	95
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRC_HUMAN
NC score	0.120475 (rank : 130)	θ value	0.125558 (rank : 69)
Query Neighborhood Hits	143	Target Neighborhood Hits	1058	Shared Neighborhood Hits	95
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ASPP2_HUMAN
NC score	0.120337 (rank : 131)	θ value	0.0431538 (rank : 57)
Query Neighborhood Hits	143	Target Neighborhood Hits	1156	Shared Neighborhood Hits	83
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ARHG4_HUMAN
NC score	0.119993 (rank : 132)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	143	Target Neighborhood Hits	242	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TXK_MOUSE
NC score	0.118106 (rank : 133)	θ value	0.0193708 (rank : 47)
Query Neighborhood Hits	143	Target Neighborhood Hits	980	Shared Neighborhood Hits	82
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SRC_MOUSE
NC score	0.116512 (rank : 134)	θ value	0.0330416 (rank : 54)
Query Neighborhood Hits	143	Target Neighborhood Hits	1033	Shared Neighborhood Hits	88
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TXK_HUMAN
NC score	0.116237 (rank : 135)	θ value	0.00102713 (rank : 30)
Query Neighborhood Hits	143	Target Neighborhood Hits	971	Shared Neighborhood Hits	81
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CASL_HUMAN
NC score	0.116025 (rank : 136)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	143	Target Neighborhood Hits	259	Shared Neighborhood Hits	77
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

NOXO1_MOUSE
NC score	0.115246 (rank : 137)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	143	Target Neighborhood Hits	114	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

CT032_HUMAN
NC score	0.114166 (rank : 138)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	143	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

RUSC1_HUMAN
NC score	0.113675 (rank : 139)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	143	Target Neighborhood Hits	226	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ITK_MOUSE
NC score	0.113114 (rank : 140)	θ value	0.00298849 (rank : 35)
Query Neighborhood Hits	143	Target Neighborhood Hits	985	Shared Neighborhood Hits	79
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

CASL_MOUSE
NC score	0.111944 (rank : 141)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	143	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

FGR_HUMAN
NC score	0.111736 (rank : 142)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	143	Target Neighborhood Hits	1067	Shared Neighborhood Hits	90
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LCK_HUMAN
NC score	0.107952 (rank : 143)	θ value	0.0736092 (rank : 62)
Query Neighborhood Hits	143	Target Neighborhood Hits	987	Shared Neighborhood Hits	72
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

FRK_HUMAN
NC score	0.107621 (rank : 144)	θ value	0.163984 (rank : 72)
Query Neighborhood Hits	143	Target Neighborhood Hits	1058	Shared Neighborhood Hits	93
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LYN_MOUSE
NC score	0.107093 (rank : 145)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	143	Target Neighborhood Hits	1023	Shared Neighborhood Hits	88
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NOXO1_HUMAN
NC score	0.106904 (rank : 146)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	143	Target Neighborhood Hits	100	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

LCK_MOUSE
NC score	0.106477 (rank : 147)	θ value	0.125558 (rank : 66)
Query Neighborhood Hits	143	Target Neighborhood Hits	981	Shared Neighborhood Hits	72
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_HUMAN
NC score	0.106413 (rank : 148)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	143	Target Neighborhood Hits	1022	Shared Neighborhood Hits	89
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LASP1_HUMAN
NC score	0.105537 (rank : 149)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	143	Target Neighborhood Hits	293	Shared Neighborhood Hits	74
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PTK6_MOUSE
NC score	0.105092 (rank : 150)	θ value	0.0193708 (rank : 46)
Query Neighborhood Hits	143	Target Neighborhood Hits	1026	Shared Neighborhood Hits	87
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

LASP1_MOUSE
NC score	0.104902 (rank : 151)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	143	Target Neighborhood Hits	297	Shared Neighborhood Hits	74
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ARHG9_MOUSE
NC score	0.104882 (rank : 152)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	143	Target Neighborhood Hits	234	Shared Neighborhood Hits	78
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FNBP2_HUMAN
NC score	0.104684 (rank : 153)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	143	Target Neighborhood Hits	432	Shared Neighborhood Hits	80
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ARHG9_HUMAN
NC score	0.102979 (rank : 154)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	143	Target Neighborhood Hits	235	Shared Neighborhood Hits	77
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

MYO1F_MOUSE
NC score	0.101117 (rank : 155)	θ value	0.279714 (rank : 80)
Query Neighborhood Hits	143	Target Neighborhood Hits	262	Shared Neighborhood Hits	93
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PTK6_HUMAN
NC score	0.101072 (rank : 156)	θ value	0.125558 (rank : 68)
Query Neighborhood Hits	143	Target Neighborhood Hits	1020	Shared Neighborhood Hits	87
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SRGP2_HUMAN
NC score	0.099867 (rank : 157)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	143	Target Neighborhood Hits	331	Shared Neighborhood Hits	85
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

MYO1F_HUMAN
NC score	0.099502 (rank : 158)	θ value	0.279714 (rank : 79)
Query Neighborhood Hits	143	Target Neighborhood Hits	275	Shared Neighborhood Hits	95
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SRGP2_MOUSE
NC score	0.099333 (rank : 159)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	143	Target Neighborhood Hits	324	Shared Neighborhood Hits	84
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
NC score	0.098224 (rank : 160)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	143	Target Neighborhood Hits	390	Shared Neighborhood Hits	81
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SH21B_MOUSE
NC score	0.095996 (rank : 161)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	143	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ABL2_HUMAN
NC score	0.095791 (rank : 162)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	143	Target Neighborhood Hits	1045	Shared Neighborhood Hits	80
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

PEX13_MOUSE
NC score	0.094945 (rank : 163)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	143	Target Neighborhood Hits	126	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RASA1_HUMAN
NC score	0.093837 (rank : 164)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	143	Target Neighborhood Hits	258	Shared Neighborhood Hits	45
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21B_HUMAN
NC score	0.093722 (rank : 165)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	143	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PEX13_HUMAN
NC score	0.093268 (rank : 166)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	143	Target Neighborhood Hits	128	Shared Neighborhood Hits	55
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ABL1_HUMAN
NC score	0.091856 (rank : 167)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	143	Target Neighborhood Hits	1220	Shared Neighborhood Hits	83
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.091727 (rank : 168)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	143	Target Neighborhood Hits	1178	Shared Neighborhood Hits	82
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

NEBL_HUMAN
NC score	0.091146 (rank : 169)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	143	Target Neighborhood Hits	457	Shared Neighborhood Hits	74
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SHLB2_MOUSE
NC score	0.090879 (rank : 170)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	143	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

CSK_MOUSE
NC score	0.090215 (rank : 171)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	143	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.090200 (rank : 172)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	143	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

SHLB2_HUMAN
NC score	0.089940 (rank : 173)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	143	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ARHG4_MOUSE
NC score	0.088890 (rank : 174)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	143	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SRMS_MOUSE
NC score	0.086090 (rank : 175)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	143	Target Neighborhood Hits	964	Shared Neighborhood Hits	63
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

DAPP1_HUMAN
NC score	0.085999 (rank : 176)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

MYO1E_HUMAN
NC score	0.085965 (rank : 177)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	143	Target Neighborhood Hits	293	Shared Neighborhood Hits	90
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SRMS_HUMAN
NC score	0.085157 (rank : 178)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	143	Target Neighborhood Hits	946	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

DAPP1_MOUSE
NC score	0.085078 (rank : 179)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	143	Target Neighborhood Hits	225	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

M3KL4_HUMAN
NC score	0.084696 (rank : 180)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	143	Target Neighborhood Hits	1087	Shared Neighborhood Hits	92
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

NEBU_HUMAN
NC score	0.082813 (rank : 181)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	143	Target Neighborhood Hits	420	Shared Neighborhood Hits	76
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RUSC1_MOUSE
NC score	0.082115 (rank : 182)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	143	Target Neighborhood Hits	206	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RIMB2_HUMAN
NC score	0.081448 (rank : 183)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	143	Target Neighborhood Hits	263	Shared Neighborhood Hits	59
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SH21A_MOUSE
NC score	0.080483 (rank : 184)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	143	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SHLB1_MOUSE
NC score	0.079755 (rank : 185)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	143	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

DDEF1_MOUSE
NC score	0.078951 (rank : 186)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	143	Target Neighborhood Hits	592	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

P85A_MOUSE
NC score	0.078503 (rank : 187)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	143	Target Neighborhood Hits	435	Shared Neighborhood Hits	65
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DDEF2_HUMAN
NC score	0.078400 (rank : 188)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	143	Target Neighborhood Hits	599	Shared Neighborhood Hits	75
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SHLB1_HUMAN
NC score	0.078387 (rank : 189)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	143	Target Neighborhood Hits	96	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

P85B_MOUSE
NC score	0.077799 (rank : 190)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	143	Target Neighborhood Hits	519	Shared Neighborhood Hits	55
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

RIMB2_MOUSE
NC score	0.077504 (rank : 191)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	143	Target Neighborhood Hits	246	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

P85B_HUMAN
NC score	0.077248 (rank : 192)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	143	Target Neighborhood Hits	543	Shared Neighborhood Hits	55
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85A_HUMAN
NC score	0.077196 (rank : 193)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	143	Target Neighborhood Hits	479	Shared Neighborhood Hits	62
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX9_MOUSE
NC score	0.075039 (rank : 194)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	143	Target Neighborhood Hits	141	Shared Neighborhood Hits	45
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SHE_MOUSE
NC score	0.074484 (rank : 195)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	143	Target Neighborhood Hits	169	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

DDEF2_MOUSE
NC score	0.074458 (rank : 196)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	143	Target Neighborhood Hits	625	Shared Neighborhood Hits	69
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

P55G_HUMAN
NC score	0.074407 (rank : 197)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	143	Target Neighborhood Hits	451	Shared Neighborhood Hits	47
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH21A_HUMAN
NC score	0.073774 (rank : 198)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	143	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SHE_HUMAN
NC score	0.072396 (rank : 199)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	143	Target Neighborhood Hits	164	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

M3K10_HUMAN
NC score	0.072138 (rank : 200)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	143	Target Neighborhood Hits	1071	Shared Neighborhood Hits	86
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

P55G_MOUSE
NC score	0.072096 (rank : 201)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	143	Target Neighborhood Hits	401	Shared Neighborhood Hits	45
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GRB14_MOUSE
NC score	0.070259 (rank : 202)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	143	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

M3K9_HUMAN
NC score	0.069675 (rank : 203)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	143	Target Neighborhood Hits	1123	Shared Neighborhood Hits	89
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

BMX_MOUSE
NC score	0.069559 (rank : 204)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	143	Target Neighborhood Hits	912	Shared Neighborhood Hits	37
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

SNX9_HUMAN
NC score	0.069501 (rank : 205)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	143	Target Neighborhood Hits	148	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

BMX_HUMAN
NC score	0.069112 (rank : 206)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	143	Target Neighborhood Hits	942	Shared Neighborhood Hits	37
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SHB_MOUSE
NC score	0.069070 (rank : 207)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	143	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

GRB14_HUMAN
NC score	0.068621 (rank : 208)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	143	Target Neighborhood Hits	137	Shared Neighborhood Hits	36
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HSH2D_HUMAN
NC score	0.068222 (rank : 209)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	143	Target Neighborhood Hits	159	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

MATK_MOUSE
NC score	0.067248 (rank : 210)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	143	Target Neighborhood Hits	952	Shared Neighborhood Hits	52
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MATK_HUMAN
NC score	0.066991 (rank : 211)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	143	Target Neighborhood Hits	954	Shared Neighborhood Hits	48
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

M3K11_HUMAN
NC score	0.066955 (rank : 212)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	143	Target Neighborhood Hits	1136	Shared Neighborhood Hits	87
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SHB_HUMAN
NC score	0.066047 (rank : 213)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	143	Target Neighborhood Hits	141	Shared Neighborhood Hits	37
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC3_MOUSE
NC score	0.065421 (rank : 214)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	143	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

TFCP2_MOUSE
NC score	0.065189 (rank : 215)	θ value	2.36792 (rank : 100)
Query Neighborhood Hits	143	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ERA0, Q3UGJ4, Q8VC13	Gene names	Tcfcp2
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2.

TFCP2_HUMAN
NC score	0.065177 (rank : 216)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	143	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q12800, Q12801, Q9UD77	Gene names	TFCP2, LSF, SEF
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2 (Transcription factor LSF) (SAA3 enhancer factor).

SHC2_MOUSE
NC score	0.064051 (rank : 217)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	143	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.063564 (rank : 218)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	143	Target Neighborhood Hits	170	Shared Neighborhood Hits	41
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC1_HUMAN
NC score	0.063339 (rank : 219)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	143	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

FER_HUMAN
NC score	0.063084 (rank : 220)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	143	Target Neighborhood Hits	1278	Shared Neighborhood Hits	52
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SHC1_MOUSE
NC score	0.062686 (rank : 221)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	143	Target Neighborhood Hits	180	Shared Neighborhood Hits	39
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHD_MOUSE
NC score	0.061074 (rank : 222)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	143	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

RHG26_HUMAN
NC score	0.060052 (rank : 223)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	143	Target Neighborhood Hits	281	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ACK1_MOUSE
NC score	0.059010 (rank : 224)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	143	Target Neighborhood Hits	1080	Shared Neighborhood Hits	49
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

GRB7_MOUSE
NC score	0.058576 (rank : 225)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	143	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

SHD_HUMAN
NC score	0.058558 (rank : 226)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	143	Target Neighborhood Hits	204	Shared Neighborhood Hits	35
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ZAP70_MOUSE
NC score	0.058406 (rank : 227)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	143	Target Neighborhood Hits	905	Shared Neighborhood Hits	41
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

LCP2_MOUSE
NC score	0.058082 (rank : 228)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	143	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SHC3_HUMAN
NC score	0.057923 (rank : 229)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	143	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

ACK1_HUMAN
NC score	0.057581 (rank : 230)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	143	Target Neighborhood Hits	1140	Shared Neighborhood Hits	47
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

TCGAP_MOUSE
NC score	0.057287 (rank : 231)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	143	Target Neighborhood Hits	409	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ZAP70_HUMAN
NC score	0.057280 (rank : 232)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	143	Target Neighborhood Hits	893	Shared Neighborhood Hits	42
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

KSYK_MOUSE
NC score	0.056483 (rank : 233)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	143	Target Neighborhood Hits	944	Shared Neighborhood Hits	43
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

APS_HUMAN
NC score	0.056130 (rank : 234)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	143	Target Neighborhood Hits	162	Shared Neighborhood Hits	34
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

KSYK_HUMAN
NC score	0.055775 (rank : 235)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	143	Target Neighborhood Hits	901	Shared Neighborhood Hits	41
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

NGEF_HUMAN
NC score	0.055671 (rank : 236)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	143	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

UBIP1_MOUSE
NC score	0.055340 (rank : 237)	θ value	0.279714 (rank : 81)
Query Neighborhood Hits	143	Target Neighborhood Hits	90	Shared Neighborhood Hits	10
SwissProt Accessions	Q811S7, Q3UPR3, Q3US11, Q60786, Q8C514	Gene names	Ubp1, Cp2b, Nf2d9
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (Nuclear factor 2d9) (NF2d9).

RIMB1_HUMAN
NC score	0.055159 (rank : 238)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	143	Target Neighborhood Hits	1479	Shared Neighborhood Hits	75
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

FES_HUMAN
NC score	0.054363 (rank : 239)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	143	Target Neighborhood Hits	978	Shared Neighborhood Hits	37
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

LTK_MOUSE
NC score	0.054112 (rank : 240)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	143	Target Neighborhood Hits	770	Shared Neighborhood Hits	27
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LTK_HUMAN
NC score	0.054090 (rank : 241)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	143	Target Neighborhood Hits	774	Shared Neighborhood Hits	26
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

RIMB1_MOUSE
NC score	0.053655 (rank : 242)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	143	Target Neighborhood Hits	1376	Shared Neighborhood Hits	81
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

GRB7_HUMAN
NC score	0.053645 (rank : 243)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	143	Target Neighborhood Hits	156	Shared Neighborhood Hits	38
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

ALK_MOUSE
NC score	0.053618 (rank : 244)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	143	Target Neighborhood Hits	811	Shared Neighborhood Hits	27
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_HUMAN
NC score	0.053402 (rank : 245)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	143	Target Neighborhood Hits	795	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

FES_MOUSE
NC score	0.053359 (rank : 246)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	143	Target Neighborhood Hits	980	Shared Neighborhood Hits	36
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

UBIP1_HUMAN
NC score	0.053171 (rank : 247)	θ value	0.125558 (rank : 70)
Query Neighborhood Hits	143	Target Neighborhood Hits	83	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZI7, Q68CT0, Q86Y57, Q9H8V0, Q9UD76, Q9UD78	Gene names	UBP1, LBP1
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (LBP-1).

NGEF_MOUSE
NC score	0.052891 (rank : 248)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	143	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RYK_HUMAN
NC score	0.052877 (rank : 249)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	143	Target Neighborhood Hits	701	Shared Neighborhood Hits	26
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

STYK1_HUMAN
NC score	0.052515 (rank : 250)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	143	Target Neighborhood Hits	786	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

ROS_HUMAN
NC score	0.052464 (rank : 251)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	143	Target Neighborhood Hits	907	Shared Neighborhood Hits	26
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

PTN11_MOUSE
NC score	0.052457 (rank : 252)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.052450 (rank : 253)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	143	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

RYK_MOUSE
NC score	0.052416 (rank : 254)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	143	Target Neighborhood Hits	715	Shared Neighborhood Hits	26
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

STYK1_MOUSE
NC score	0.052210 (rank : 255)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	143	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SH24A_HUMAN
NC score	0.051800 (rank : 256)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	143	Target Neighborhood Hits	455	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

LCP2_HUMAN
NC score	0.051721 (rank : 257)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	143	Target Neighborhood Hits	531	Shared Neighborhood Hits	40
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

AATK_MOUSE
NC score	0.051599 (rank : 258)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	143	Target Neighborhood Hits	942	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

LNK_HUMAN
NC score	0.051562 (rank : 259)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	143	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SH2D3_MOUSE
NC score	0.051296 (rank : 260)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	143	Target Neighborhood Hits	174	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

EPHAA_HUMAN
NC score	0.050848 (rank : 261)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	143	Target Neighborhood Hits	960	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

AATK_HUMAN
NC score	0.050835 (rank : 262)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	143	Target Neighborhood Hits	1243	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

DDR1_MOUSE
NC score	0.050817 (rank : 263)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	143	Target Neighborhood Hits	818	Shared Neighborhood Hits	26
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

TNK1_HUMAN
NC score	0.050654 (rank : 264)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	143	Target Neighborhood Hits	815	Shared Neighborhood Hits	28
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

DDR1_HUMAN
NC score	0.050622 (rank : 265)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	143	Target Neighborhood Hits	819	Shared Neighborhood Hits	26
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

FAK2_HUMAN
NC score	0.050592 (rank : 266)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	143	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

GRB10_MOUSE
NC score	0.050515 (rank : 267)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	143	Target Neighborhood Hits	156	Shared Neighborhood Hits	36
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

FAK2_MOUSE
NC score	0.050359 (rank : 268)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	143	Target Neighborhood Hits	851	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ERBB2_HUMAN
NC score	0.050282 (rank : 269)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	143	Target Neighborhood Hits	1073	Shared Neighborhood Hits	33
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

EPHB6_HUMAN
NC score	0.050184 (rank : 270)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	143	Target Neighborhood Hits	912	Shared Neighborhood Hits	26
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

PRPC_HUMAN
NC score	0.047698 (rank : 271)	θ value	0.163984 (rank : 75)
Query Neighborhood Hits	143	Target Neighborhood Hits	165	Shared Neighborhood Hits	14
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

FYB_HUMAN
NC score	0.035902 (rank : 272)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	143	Target Neighborhood Hits	379	Shared Neighborhood Hits	26
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

AXN1_HUMAN
NC score	0.027935 (rank : 273)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	143	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

GG12A_HUMAN
NC score	0.023314 (rank : 274)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	143	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	Q4V321	Gene names	GAGE12A
Domain Architecture	No domain graphic available
Description	G antigen 12A (GAGE-12A).

GAGE1_HUMAN
NC score	0.022566 (rank : 275)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	143	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q13065	Gene names	GAGE1
Domain Architecture
Description	G antigen 1 (GAGE-1) (MZ2-F antigen).

GAGE8_HUMAN
NC score	0.022394 (rank : 276)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	143	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UEU5, Q4V325	Gene names	GAGE8
Domain Architecture
Description	G antigen 8 (GAGE-8).

GAGE2_HUMAN
NC score	0.022345 (rank : 277)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	143	Target Neighborhood Hits	50	Shared Neighborhood Hits	12
SwissProt Accessions	Q13066, Q4V322	Gene names	GAGE2
Domain Architecture	No domain graphic available
Description	G antigen 2 (GAGE-2).

GAGE3_HUMAN
NC score	0.022105 (rank : 278)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	143	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13067	Gene names	GAGE3
Domain Architecture
Description	G antigen 3 (GAGE-3).

SVIL_MOUSE
NC score	0.022032 (rank : 279)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	143	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

MDC1_MOUSE
NC score	0.022032 (rank : 280)	θ value	0.21417 (rank : 77)
Query Neighborhood Hits	143	Target Neighborhood Hits	998	Shared Neighborhood Hits	21
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

GAGE4_HUMAN
NC score	0.021922 (rank : 281)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	143	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13068, Q6NT33	Gene names	GAGE4
Domain Architecture
Description	G antigen 4 (GAGE-4).

GAGE5_HUMAN
NC score	0.021914 (rank : 282)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	143	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q13069, Q6FG72	Gene names	GAGE5
Domain Architecture
Description	G antigen 5 (GAGE-5).

GAGE6_HUMAN
NC score	0.021891 (rank : 283)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	143	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	Q13070	Gene names	GAGE6
Domain Architecture
Description	G antigen 6 (GAGE-6).

GAGE7_HUMAN
NC score	0.021884 (rank : 284)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	143	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	O76087, Q4V324	Gene names	GAGE7B, GAGE7
Domain Architecture
Description	G antigen 7 (GAGE-7) (GAGE-7B) (GAGE-8) (AL4).

SNPC2_HUMAN
NC score	0.021102 (rank : 285)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	143	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q13487, Q13486	Gene names	SNAPC2, SNAP45
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE- binding factor subunit delta) (PTF subunit delta).

CN155_HUMAN
NC score	0.020763 (rank : 286)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	143	Target Neighborhood Hits	385	Shared Neighborhood Hits	18
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

SPEG_MOUSE
NC score	0.020673 (rank : 287)	θ value	1.81305 (rank : 94)
Query Neighborhood Hits	143	Target Neighborhood Hits	1959	Shared Neighborhood Hits	45
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SET1A_HUMAN
NC score	0.017473 (rank : 288)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	143	Target Neighborhood Hits	690	Shared Neighborhood Hits	20
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

MSPD3_MOUSE
NC score	0.017427 (rank : 289)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	143	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGG6	Gene names	Mospd3
Domain Architecture	No domain graphic available
Description	Motile sperm domain-containing protein 3.

CAC1H_HUMAN
NC score	0.017186 (rank : 290)	θ value	0.0563607 (rank : 58)
Query Neighborhood Hits	143	Target Neighborhood Hits	307	Shared Neighborhood Hits	5
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

RTN1_MOUSE
NC score	0.016831 (rank : 291)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	143	Target Neighborhood Hits	189	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

CDT1_HUMAN
NC score	0.016480 (rank : 292)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	143	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

CJ095_HUMAN
NC score	0.016279 (rank : 293)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	143	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H7T3	Gene names	C10orf95
Domain Architecture	No domain graphic available
Description	Protein C10orf95.

RTN4_MOUSE
NC score	0.015773 (rank : 294)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	143	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

PRP1_HUMAN
NC score	0.015034 (rank : 295)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	143	Target Neighborhood Hits	385	Shared Neighborhood Hits	23
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

ACINU_HUMAN
NC score	0.013127 (rank : 296)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	143	Target Neighborhood Hits	828	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

MEGF9_MOUSE
NC score	0.012417 (rank : 297)	θ value	0.279714 (rank : 78)
Query Neighborhood Hits	143	Target Neighborhood Hits	896	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

ZIMP7_MOUSE
NC score	0.012241 (rank : 298)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	143	Target Neighborhood Hits	566	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

RHG06_MOUSE
NC score	0.011750 (rank : 299)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	143	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

K0240_MOUSE
NC score	0.009606 (rank : 300)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	143	Target Neighborhood Hits	211	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

FRS2_HUMAN
NC score	0.009572 (rank : 301)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	143	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

FA43B_HUMAN
NC score	0.009535 (rank : 302)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	143	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZT52	Gene names	FAM43B
Domain Architecture	No domain graphic available
Description	Protein FAM43B.

BAT3_MOUSE
NC score	0.008980 (rank : 303)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	143	Target Neighborhood Hits	518	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

MLL3_HUMAN
NC score	0.007601 (rank : 304)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	143	Target Neighborhood Hits	1644	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SIPA1_MOUSE
NC score	0.007467 (rank : 305)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	143	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

HTSF1_MOUSE
NC score	0.006292 (rank : 306)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	143	Target Neighborhood Hits	425	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

PDLI7_HUMAN
NC score	0.005846 (rank : 307)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	143	Target Neighborhood Hits	547	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

DNM3A_MOUSE
NC score	0.005533 (rank : 308)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	143	Target Neighborhood Hits	91	Shared Neighborhood Hits	3
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

CLIC6_MOUSE
NC score	0.005464 (rank : 309)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	143	Target Neighborhood Hits	134	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

OXRP_HUMAN
NC score	0.005365 (rank : 310)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	143	Target Neighborhood Hits	544	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

TIA1_HUMAN
NC score	0.003189 (rank : 311)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	143	Target Neighborhood Hits	236	Shared Neighborhood Hits	3
SwissProt Accessions	P31483	Gene names	TIA1
Domain Architecture	No domain graphic available
Description	Nucleolysin TIA-1 isoform p40 (RNA-binding protein TIA-1) (p40-TIA-1) [Contains: Nucleolysin TIA-1 isoform p15 (p15-TIA-1)].

ZBT7B_MOUSE
NC score	-0.001890 (rank : 312)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	143	Target Neighborhood Hits	792	Shared Neighborhood Hits	3
SwissProt Accessions	Q64321, Q80VV5	Gene names	Zbtb7b, Thpok, Zfp67
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 7B (Zinc finger protein 67) (Zfp-67) (Zinc finger protein Th-POK) (T-helper-inducing POZ/Krueppel-like factor) (Krueppel-related zinc finger protein cKrox) (c-Krox).