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Network neighborhood for query Sequence : EPS8_MOUSE

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EPS8_MOUSE
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EPS8_HUMAN
θ value	0 (rank : 1)	NC score	0.991035 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	151	Shared Neighborhood Hits	117
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L2_HUMAN
θ value	1.12714e-143 (rank : 3)	NC score	0.940033 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	193	Shared Neighborhood Hits	110
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	1.43246e-122 (rank : 4)	NC score	0.941175 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	105
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L1_MOUSE
θ value	6.228e-118 (rank : 5)	NC score	0.932280 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	143	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_HUMAN
θ value	9.32813e-106 (rank : 6)	NC score	0.929878 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L3_HUMAN
θ value	1.41016e-61 (rank : 7)	NC score	0.871577 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	206	Shared Neighborhood Hits	105
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	3.36421e-55 (rank : 8)	NC score	0.876447 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	168	Shared Neighborhood Hits	111
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NCK2_HUMAN
θ value	5.26297e-08 (rank : 9)	NC score	0.379859 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	310	Shared Neighborhood Hits	128
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
θ value	8.97725e-08 (rank : 10)	NC score	0.368442 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CRKL_MOUSE
θ value	9.29e-05 (rank : 11)	NC score	0.342954 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	122
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
θ value	0.000121331 (rank : 12)	NC score	0.343758 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	313	Shared Neighborhood Hits	125
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRAP2_HUMAN
θ value	0.00020696 (rank : 13)	NC score	0.306967 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	304	Shared Neighborhood Hits	131
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	0.000270298 (rank : 14)	NC score	0.308035 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	297	Shared Neighborhood Hits	130
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

BLK_HUMAN
θ value	0.000786445 (rank : 15)	NC score	0.110522 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	994	Shared Neighborhood Hits	103
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PPIP1_HUMAN
θ value	0.000786445 (rank : 16)	NC score	0.312976 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	389	Shared Neighborhood Hits	130
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

BTK_HUMAN
θ value	0.00102713 (rank : 17)	NC score	0.122981 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	1026	Shared Neighborhood Hits	127
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

VAV_MOUSE
θ value	0.00102713 (rank : 18)	NC score	0.223825 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	430	Shared Neighborhood Hits	126
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

BLK_MOUSE
θ value	0.00134147 (rank : 19)	NC score	0.111917 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	992	Shared Neighborhood Hits	94
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_HUMAN
θ value	0.00175202 (rank : 20)	NC score	0.111329 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	1035	Shared Neighborhood Hits	125
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

VAV_HUMAN
θ value	0.00175202 (rank : 21)	NC score	0.227378 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	452	Shared Neighborhood Hits	128
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

BTK_MOUSE
θ value	0.00228821 (rank : 22)	NC score	0.121474 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	1017	Shared Neighborhood Hits	121
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ITSN1_MOUSE
θ value	0.00228821 (rank : 23)	NC score	0.169457 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	1669	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SNX18_MOUSE
θ value	0.00228821 (rank : 24)	NC score	0.217558 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	98
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

GRB2_HUMAN
θ value	0.00298849 (rank : 25)	NC score	0.288305 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	310	Shared Neighborhood Hits	129
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00298849 (rank : 26)	NC score	0.287370 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SNX18_HUMAN
θ value	0.00298849 (rank : 27)	NC score	0.207745 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	207	Shared Neighborhood Hits	99
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PPIP1_MOUSE
θ value	0.00390308 (rank : 28)	NC score	0.296124 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	377	Shared Neighborhood Hits	131
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SPTA1_MOUSE
θ value	0.00390308 (rank : 29)	NC score	0.158639 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	675	Shared Neighborhood Hits	125
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

HCK_MOUSE
θ value	0.00509761 (rank : 30)	NC score	0.108504 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	1029	Shared Neighborhood Hits	125
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

BCAR1_MOUSE
θ value	0.00665767 (rank : 31)	NC score	0.203863 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	438	Shared Neighborhood Hits	113
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CRK_MOUSE
θ value	0.0113563 (rank : 32)	NC score	0.307746 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	125
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP_MOUSE
θ value	0.0113563 (rank : 33)	NC score	0.283831 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	309	Shared Neighborhood Hits	128
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CRK_HUMAN
θ value	0.0148317 (rank : 34)	NC score	0.302420 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	308	Shared Neighborhood Hits	125
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MYO1F_HUMAN
θ value	0.0148317 (rank : 35)	NC score	0.112081 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	275	Shared Neighborhood Hits	121
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

AHI1_HUMAN
θ value	0.0193708 (rank : 36)	NC score	0.215678 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	537	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

FNBP2_HUMAN
θ value	0.0193708 (rank : 37)	NC score	0.111100 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	432	Shared Neighborhood Hits	103
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

BCAR1_HUMAN
θ value	0.0252991 (rank : 38)	NC score	0.196865 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	554	Shared Neighborhood Hits	115
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NPHP1_MOUSE
θ value	0.0252991 (rank : 39)	NC score	0.301036 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	267	Shared Neighborhood Hits	124
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

AHI1_MOUSE
θ value	0.0431538 (rank : 40)	NC score	0.208777 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

GRAP_HUMAN
θ value	0.0431538 (rank : 41)	NC score	0.292299 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	130
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

VINEX_MOUSE
θ value	0.0431538 (rank : 42)	NC score	0.275487 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	286	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ASPP1_HUMAN
θ value	0.0563607 (rank : 43)	NC score	0.150914 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	956	Shared Neighborhood Hits	105
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SPTA1_HUMAN
θ value	0.0563607 (rank : 44)	NC score	0.130733 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	748	Shared Neighborhood Hits	125
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TXK_HUMAN
θ value	0.0563607 (rank : 45)	NC score	0.096526 (rank : 161)
Query Neighborhood Hits	157	Target Neighborhood Hits	971	Shared Neighborhood Hits	104
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CD2AP_MOUSE
θ value	0.0736092 (rank : 46)	NC score	0.255747 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	336	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CIP4_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.176986 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	374	Shared Neighborhood Hits	66
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

DNMBP_MOUSE
θ value	0.0736092 (rank : 48)	NC score	0.236276 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	435	Shared Neighborhood Hits	131
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NPHP1_HUMAN
θ value	0.0736092 (rank : 49)	NC score	0.292539 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	288	Shared Neighborhood Hits	118
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

DNMBP_HUMAN
θ value	0.0961366 (rank : 50)	NC score	0.247903 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	413	Shared Neighborhood Hits	131
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LYN_MOUSE
θ value	0.0961366 (rank : 51)	NC score	0.092175 (rank : 169)
Query Neighborhood Hits	157	Target Neighborhood Hits	1023	Shared Neighborhood Hits	110
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MYO1F_MOUSE
θ value	0.0961366 (rank : 52)	NC score	0.113495 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	262	Shared Neighborhood Hits	121
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PTK6_MOUSE
θ value	0.0961366 (rank : 53)	NC score	0.089916 (rank : 175)
Query Neighborhood Hits	157	Target Neighborhood Hits	1026	Shared Neighborhood Hits	115
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

VINEX_HUMAN
θ value	0.0961366 (rank : 54)	NC score	0.250129 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	270	Shared Neighborhood Hits	122
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

DDEF2_MOUSE
θ value	0.125558 (rank : 55)	NC score	0.102991 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	625	Shared Neighborhood Hits	102
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ITK_HUMAN
θ value	0.125558 (rank : 56)	NC score	0.097981 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	1016	Shared Neighborhood Hits	103
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SRGP1_HUMAN
θ value	0.125558 (rank : 57)	NC score	0.101257 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	390	Shared Neighborhood Hits	102
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ASPP1_MOUSE
θ value	0.163984 (rank : 58)	NC score	0.140632 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	1244	Shared Neighborhood Hits	111
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DDEF2_HUMAN
θ value	0.163984 (rank : 59)	NC score	0.105706 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	599	Shared Neighborhood Hits	101
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

TXK_MOUSE
θ value	0.163984 (rank : 60)	NC score	0.098911 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	980	Shared Neighborhood Hits	110
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ABL2_HUMAN
θ value	0.21417 (rank : 61)	NC score	0.086007 (rank : 180)
Query Neighborhood Hits	157	Target Neighborhood Hits	1045	Shared Neighborhood Hits	91
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ARHG6_MOUSE
θ value	0.21417 (rank : 62)	NC score	0.206610 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	394	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ITK_MOUSE
θ value	0.21417 (rank : 63)	NC score	0.089513 (rank : 177)
Query Neighborhood Hits	157	Target Neighborhood Hits	985	Shared Neighborhood Hits	91
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITSN1_HUMAN
θ value	0.21417 (rank : 64)	NC score	0.161021 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	1757	Shared Neighborhood Hits	137
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

TFCP2_HUMAN
θ value	0.21417 (rank : 65)	NC score	0.057884 (rank : 226)
Query Neighborhood Hits	157	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q12800, Q12801, Q9UD77	Gene names	TFCP2, LSF, SEF
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2 (Transcription factor LSF) (SAA3 enhancer factor).

TFCP2_MOUSE
θ value	0.21417 (rank : 66)	NC score	0.057921 (rank : 225)
Query Neighborhood Hits	157	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERA0, Q3UGJ4, Q8VC13	Gene names	Tcfcp2
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2.

LYN_HUMAN
θ value	0.279714 (rank : 67)	NC score	0.090846 (rank : 172)
Query Neighborhood Hits	157	Target Neighborhood Hits	1022	Shared Neighborhood Hits	112
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ARHG7_MOUSE
θ value	0.365318 (rank : 68)	NC score	0.207792 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	396	Shared Neighborhood Hits	126
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

PACN2_HUMAN
θ value	0.365318 (rank : 69)	NC score	0.178329 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	339	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PTK6_HUMAN
θ value	0.365318 (rank : 70)	NC score	0.085626 (rank : 182)
Query Neighborhood Hits	157	Target Neighborhood Hits	1020	Shared Neighborhood Hits	116
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SH3K1_MOUSE
θ value	0.365318 (rank : 71)	NC score	0.228083 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	332	Shared Neighborhood Hits	118
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STAM1_MOUSE
θ value	0.365318 (rank : 72)	NC score	0.259662 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	273	Shared Neighborhood Hits	123
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

VAV3_HUMAN
θ value	0.365318 (rank : 73)	NC score	0.188369 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	398	Shared Neighborhood Hits	126
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG4_HUMAN
θ value	0.47712 (rank : 74)	NC score	0.134750 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	242	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG7_HUMAN
θ value	0.47712 (rank : 75)	NC score	0.194709 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	347	Shared Neighborhood Hits	122
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CSK_HUMAN
θ value	0.47712 (rank : 76)	NC score	0.081501 (rank : 186)
Query Neighborhood Hits	157	Target Neighborhood Hits	1009	Shared Neighborhood Hits	105
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.47712 (rank : 77)	NC score	0.081690 (rank : 185)
Query Neighborhood Hits	157	Target Neighborhood Hits	1009	Shared Neighborhood Hits	105
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

MYO1E_HUMAN
θ value	0.47712 (rank : 78)	NC score	0.097161 (rank : 160)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SPTA2_HUMAN
θ value	0.47712 (rank : 79)	NC score	0.129766 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	888	Shared Neighborhood Hits	128
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAM1_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.251171 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	271	Shared Neighborhood Hits	124
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG6_HUMAN
θ value	0.813845 (rank : 81)	NC score	0.184012 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	376	Shared Neighborhood Hits	118
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CASL_HUMAN
θ value	0.813845 (rank : 82)	NC score	0.164751 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	259	Shared Neighborhood Hits	102
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

ITSN2_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.170421 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	1173	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PACN2_MOUSE
θ value	0.813845 (rank : 84)	NC score	0.185613 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G2_HUMAN
θ value	0.813845 (rank : 85)	NC score	0.189251 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	324	Shared Neighborhood Hits	119
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
θ value	0.813845 (rank : 86)	NC score	0.195094 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	222	Shared Neighborhood Hits	112
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.206147 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	236	Shared Neighborhood Hits	117
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_MOUSE
θ value	0.813845 (rank : 88)	NC score	0.217799 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	409	Shared Neighborhood Hits	122
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM2_HUMAN
θ value	0.813845 (rank : 89)	NC score	0.260033 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	288	Shared Neighborhood Hits	124
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

TEC_HUMAN
θ value	0.813845 (rank : 90)	NC score	0.097243 (rank : 159)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	105
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VAV3_MOUSE
θ value	0.813845 (rank : 91)	NC score	0.180693 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	404	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CD2AP_HUMAN
θ value	1.06291 (rank : 92)	NC score	0.236412 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	315	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CT032_HUMAN
θ value	1.06291 (rank : 93)	NC score	0.159630 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	235	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

EFS_MOUSE
θ value	1.06291 (rank : 94)	NC score	0.207898 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	389	Shared Neighborhood Hits	102
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SH3G1_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.186489 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	116
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STAM2_MOUSE
θ value	1.06291 (rank : 96)	NC score	0.263976 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	285	Shared Neighborhood Hits	124
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TEC_MOUSE
θ value	1.06291 (rank : 97)	NC score	0.096474 (rank : 162)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	106
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LCK_HUMAN
θ value	1.38821 (rank : 98)	NC score	0.091967 (rank : 170)
Query Neighborhood Hits	157	Target Neighborhood Hits	987	Shared Neighborhood Hits	89
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	1.38821 (rank : 99)	NC score	0.090530 (rank : 173)
Query Neighborhood Hits	157	Target Neighborhood Hits	981	Shared Neighborhood Hits	88
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MINT_MOUSE
θ value	1.38821 (rank : 100)	NC score	0.015009 (rank : 261)
Query Neighborhood Hits	157	Target Neighborhood Hits	1514	Shared Neighborhood Hits	23
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SRBS1_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.209829 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	396	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	1.38821 (rank : 102)	NC score	0.174785 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	269	Shared Neighborhood Hits	120
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ITSN2_MOUSE
θ value	1.81305 (rank : 103)	NC score	0.158425 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	1371	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RUSC2_MOUSE
θ value	1.81305 (rank : 104)	NC score	0.048054 (rank : 254)
Query Neighborhood Hits	157	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SH3K1_HUMAN
θ value	1.81305 (rank : 105)	NC score	0.224450 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	341	Shared Neighborhood Hits	118
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

VAV2_MOUSE
θ value	1.81305 (rank : 106)	NC score	0.174697 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	456	Shared Neighborhood Hits	124
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FRK_HUMAN
θ value	2.36792 (rank : 107)	NC score	0.090297 (rank : 174)
Query Neighborhood Hits	157	Target Neighborhood Hits	1058	Shared Neighborhood Hits	123
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

SH3G2_MOUSE
θ value	2.36792 (rank : 108)	NC score	0.189677 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	319	Shared Neighborhood Hits	117
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SRC8_MOUSE
θ value	2.36792 (rank : 109)	NC score	0.170180 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	292	Shared Neighborhood Hits	121
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRMS_HUMAN
θ value	2.36792 (rank : 110)	NC score	0.072275 (rank : 201)
Query Neighborhood Hits	157	Target Neighborhood Hits	946	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

VAV2_HUMAN
θ value	2.36792 (rank : 111)	NC score	0.173810 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	453	Shared Neighborhood Hits	125
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ABL1_HUMAN
θ value	3.0926 (rank : 112)	NC score	0.081234 (rank : 187)
Query Neighborhood Hits	157	Target Neighborhood Hits	1220	Shared Neighborhood Hits	99
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	3.0926 (rank : 113)	NC score	0.081015 (rank : 188)
Query Neighborhood Hits	157	Target Neighborhood Hits	1178	Shared Neighborhood Hits	99
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

NCOR2_MOUSE
θ value	3.0926 (rank : 114)	NC score	0.011908 (rank : 262)
Query Neighborhood Hits	157	Target Neighborhood Hits	790	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

PAX3_HUMAN
θ value	3.0926 (rank : 115)	NC score	0.006414 (rank : 270)
Query Neighborhood Hits	157	Target Neighborhood Hits	513	Shared Neighborhood Hits	5
SwissProt Accessions	P23760, Q16448	Gene names	PAX3, HUP2
Domain Architecture
Description	Paired box protein Pax-3 (HUP2).

PLCG2_HUMAN
θ value	3.0926 (rank : 116)	NC score	0.141781 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	280	Shared Neighborhood Hits	112
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SHLB1_MOUSE
θ value	3.0926 (rank : 117)	NC score	0.108201 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

STAC_HUMAN
θ value	3.0926 (rank : 118)	NC score	0.205858 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	276	Shared Neighborhood Hits	120
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI3_HUMAN
θ value	4.03905 (rank : 119)	NC score	0.140080 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	97
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG9_MOUSE
θ value	4.03905 (rank : 120)	NC score	0.116832 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	234	Shared Neighborhood Hits	102
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARH_MOUSE
θ value	4.03905 (rank : 121)	NC score	0.025193 (rank : 256)
Query Neighborhood Hits	157	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

CYTSA_HUMAN
θ value	4.03905 (rank : 122)	NC score	0.007547 (rank : 266)
Query Neighborhood Hits	157	Target Neighborhood Hits	1138	Shared Neighborhood Hits	20
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

OSTF1_HUMAN
θ value	4.03905 (rank : 123)	NC score	0.165789 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	466	Shared Neighborhood Hits	118
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3G1_MOUSE
θ value	4.03905 (rank : 124)	NC score	0.184569 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	291	Shared Neighborhood Hits	119
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CASL_MOUSE
θ value	5.27518 (rank : 125)	NC score	0.160758 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	225	Shared Neighborhood Hits	107
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

DAF1_MOUSE
θ value	5.27518 (rank : 126)	NC score	0.005884 (rank : 271)
Query Neighborhood Hits	157	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

DBNL_HUMAN
θ value	5.27518 (rank : 127)	NC score	0.151886 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	244	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	5.27518 (rank : 128)	NC score	0.152960 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	306	Shared Neighborhood Hits	106
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

GLI3_HUMAN
θ value	5.27518 (rank : 129)	NC score	-0.002950 (rank : 278)
Query Neighborhood Hits	157	Target Neighborhood Hits	871	Shared Neighborhood Hits	5
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

NCF4_MOUSE
θ value	5.27518 (rank : 130)	NC score	0.157127 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	177	Shared Neighborhood Hits	100
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NOS3_MOUSE
θ value	5.27518 (rank : 131)	NC score	0.010165 (rank : 263)
Query Neighborhood Hits	157	Target Neighborhood Hits	63	Shared Neighborhood Hits	5
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

OSTF1_MOUSE
θ value	5.27518 (rank : 132)	NC score	0.158130 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	467	Shared Neighborhood Hits	119
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PEX13_MOUSE
θ value	5.27518 (rank : 133)	NC score	0.124536 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	126	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SHLB1_HUMAN
θ value	5.27518 (rank : 134)	NC score	0.104682 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

ABCA7_HUMAN
θ value	6.88961 (rank : 135)	NC score	0.002477 (rank : 276)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

ARH_HUMAN
θ value	6.88961 (rank : 136)	NC score	0.019944 (rank : 258)
Query Neighborhood Hits	157	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

HCLS1_HUMAN
θ value	6.88961 (rank : 137)	NC score	0.167206 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	358	Shared Neighborhood Hits	114
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NOS3_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.009964 (rank : 264)
Query Neighborhood Hits	157	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

PDLI7_HUMAN
θ value	6.88961 (rank : 139)	NC score	0.004903 (rank : 272)
Query Neighborhood Hits	157	Target Neighborhood Hits	547	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SRMS_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.073681 (rank : 197)
Query Neighborhood Hits	157	Target Neighborhood Hits	964	Shared Neighborhood Hits	80
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STAC_MOUSE
θ value	6.88961 (rank : 141)	NC score	0.175511 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	268	Shared Neighborhood Hits	116
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TOM1_HUMAN
θ value	6.88961 (rank : 142)	NC score	0.021625 (rank : 257)
Query Neighborhood Hits	157	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	O60784, Q5TIJ6	Gene names	TOM1
Domain Architecture
Description	Target of Myb protein 1.

USH1C_MOUSE
θ value	6.88961 (rank : 143)	NC score	0.006932 (rank : 269)
Query Neighborhood Hits	157	Target Neighborhood Hits	557	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

ABI3_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.140071 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	98
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CD2L7_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.018317 (rank : 259)
Query Neighborhood Hits	157	Target Neighborhood Hits	1275	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

DDX31_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.002044 (rank : 277)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DOCK1_HUMAN
θ value	8.99809 (rank : 147)	NC score	0.055457 (rank : 231)
Query Neighborhood Hits	157	Target Neighborhood Hits	191	Shared Neighborhood Hits	77
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

EFS_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.184715 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	348	Shared Neighborhood Hits	102
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

FA53B_HUMAN
θ value	8.99809 (rank : 149)	NC score	0.009200 (rank : 265)
Query Neighborhood Hits	157	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q14153, Q8N5S6	Gene names	FAM53B, KIAA0140
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

GAB1_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.007274 (rank : 267)
Query Neighborhood Hits	157	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

KIF5C_MOUSE
θ value	8.99809 (rank : 151)	NC score	0.003596 (rank : 274)
Query Neighborhood Hits	157	Target Neighborhood Hits	1040	Shared Neighborhood Hits	25
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

MEPE_HUMAN
θ value	8.99809 (rank : 152)	NC score	0.015153 (rank : 260)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

SCNNB_HUMAN
θ value	8.99809 (rank : 153)	NC score	0.004610 (rank : 273)
Query Neighborhood Hits	157	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P51168, O60891, Q96KG2, Q9UJ32, Q9UMU5	Gene names	SCNN1B
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH) (ENaCB).

SPR1A_MOUSE
θ value	8.99809 (rank : 154)	NC score	0.003302 (rank : 275)
Query Neighborhood Hits	157	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SRGP2_MOUSE
θ value	8.99809 (rank : 155)	NC score	0.099342 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	324	Shared Neighborhood Hits	103
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

TR19L_HUMAN
θ value	8.99809 (rank : 156)	NC score	0.007177 (rank : 268)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q969Z4, Q86V34, Q96JU1, Q9BUX7	Gene names	TNFRSF19L, RELT
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19L precursor (Receptor expressed in lymphoid tissues).

TRIO_HUMAN
θ value	8.99809 (rank : 157)	NC score	0.042432 (rank : 255)
Query Neighborhood Hits	157	Target Neighborhood Hits	1580	Shared Neighborhood Hits	74
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ABI1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.133154 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	257	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.139756 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	246	Shared Neighborhood Hits	107
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.153587 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	350	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.154452 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	266	Shared Neighborhood Hits	110
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ANM2_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.111339 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	103
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.112532 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	105
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APS_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.066322 (rank : 210)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	40
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.053365 (rank : 239)
Query Neighborhood Hits	157	Target Neighborhood Hits	134	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG4_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.099765 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	185	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.056149 (rank : 230)
Query Neighborhood Hits	157	Target Neighborhood Hits	172	Shared Neighborhood Hits	59
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG9_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.113224 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	235	Shared Neighborhood Hits	101
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ASPP2_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.098096 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	1156	Shared Neighborhood Hits	97
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCAR3_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.051702 (rank : 245)
Query Neighborhood Hits	157	Target Neighborhood Hits	129	Shared Neighborhood Hits	31
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.051346 (rank : 248)
Query Neighborhood Hits	157	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BMX_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.050970 (rank : 251)
Query Neighborhood Hits	157	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.051379 (rank : 246)
Query Neighborhood Hits	157	Target Neighborhood Hits	912	Shared Neighborhood Hits	44
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

DAPP1_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.086025 (rank : 179)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.085636 (rank : 181)
Query Neighborhood Hits	157	Target Neighborhood Hits	225	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.099127 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	592	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FER_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.050884 (rank : 252)
Query Neighborhood Hits	157	Target Neighborhood Hits	1278	Shared Neighborhood Hits	59
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGR_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.092348 (rank : 168)
Query Neighborhood Hits	157	Target Neighborhood Hits	1067	Shared Neighborhood Hits	120
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.099545 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	1069	Shared Neighborhood Hits	123
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.101159 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	1078	Shared Neighborhood Hits	125
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.102655 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	1073	Shared Neighborhood Hits	125
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GRB10_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.052603 (rank : 243)
Query Neighborhood Hits	157	Target Neighborhood Hits	147	Shared Neighborhood Hits	40
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.053235 (rank : 242)
Query Neighborhood Hits	157	Target Neighborhood Hits	156	Shared Neighborhood Hits	42
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.071274 (rank : 203)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	42
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.072586 (rank : 200)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.058889 (rank : 224)
Query Neighborhood Hits	157	Target Neighborhood Hits	156	Shared Neighborhood Hits	42
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.064480 (rank : 215)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HCLS1_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.166546 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	329	Shared Neighborhood Hits	115
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HSH2D_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.075198 (rank : 195)
Query Neighborhood Hits	157	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.054978 (rank : 233)
Query Neighborhood Hits	157	Target Neighborhood Hits	124	Shared Neighborhood Hits	30
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.114164 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	688	Shared Neighborhood Hits	112
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.102953 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	1024	Shared Neighborhood Hits	116
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.119631 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	103
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.117611 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	297	Shared Neighborhood Hits	102
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LNK_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.064650 (rank : 214)
Query Neighborhood Hits	157	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.064471 (rank : 216)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

M3K10_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.061786 (rank : 221)
Query Neighborhood Hits	157	Target Neighborhood Hits	1071	Shared Neighborhood Hits	112
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.059225 (rank : 223)
Query Neighborhood Hits	157	Target Neighborhood Hits	1136	Shared Neighborhood Hits	119
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.060317 (rank : 222)
Query Neighborhood Hits	157	Target Neighborhood Hits	1123	Shared Neighborhood Hits	117
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.075289 (rank : 193)
Query Neighborhood Hits	157	Target Neighborhood Hits	1087	Shared Neighborhood Hits	121
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MATK_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.056837 (rank : 229)
Query Neighborhood Hits	157	Target Neighborhood Hits	954	Shared Neighborhood Hits	62
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.056845 (rank : 228)
Query Neighborhood Hits	157	Target Neighborhood Hits	952	Shared Neighborhood Hits	67
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.054705 (rank : 235)
Query Neighborhood Hits	157	Target Neighborhood Hits	255	Shared Neighborhood Hits	36
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

NCF1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.212396 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	108
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.193884 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.253152 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	229	Shared Neighborhood Hits	112
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.142455 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	161	Shared Neighborhood Hits	90
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.106400 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	457	Shared Neighborhood Hits	106
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.092952 (rank : 166)
Query Neighborhood Hits	157	Target Neighborhood Hits	420	Shared Neighborhood Hits	110
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.054155 (rank : 237)
Query Neighborhood Hits	157	Target Neighborhood Hits	166	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.055011 (rank : 232)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.094884 (rank : 164)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.112046 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	67
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

P55G_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.071297 (rank : 202)
Query Neighborhood Hits	157	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.070599 (rank : 204)
Query Neighborhood Hits	157	Target Neighborhood Hits	401	Shared Neighborhood Hits	53
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.078113 (rank : 191)
Query Neighborhood Hits	157	Target Neighborhood Hits	479	Shared Neighborhood Hits	76
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.080395 (rank : 189)
Query Neighborhood Hits	157	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.075258 (rank : 194)
Query Neighborhood Hits	157	Target Neighborhood Hits	543	Shared Neighborhood Hits	64
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.075661 (rank : 192)
Query Neighborhood Hits	157	Target Neighborhood Hits	519	Shared Neighborhood Hits	64
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.174540 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	320	Shared Neighborhood Hits	123
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.169263 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	283	Shared Neighborhood Hits	122
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN3_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.161008 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	385	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.160127 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	380	Shared Neighborhood Hits	120
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.119583 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	128	Shared Neighborhood Hits	79
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.051767 (rank : 244)
Query Neighborhood Hits	157	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG1_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.135224 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.137277 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	113
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PTN11_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.053300 (rank : 241)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.053308 (rank : 240)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

RASA1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.091044 (rank : 171)
Query Neighborhood Hits	157	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG04_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.120975 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	108
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.070232 (rank : 206)
Query Neighborhood Hits	157	Target Neighborhood Hits	281	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.054643 (rank : 236)
Query Neighborhood Hits	157	Target Neighborhood Hits	1479	Shared Neighborhood Hits	98
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.053426 (rank : 238)
Query Neighborhood Hits	157	Target Neighborhood Hits	1376	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.086066 (rank : 178)
Query Neighborhood Hits	157	Target Neighborhood Hits	263	Shared Neighborhood Hits	79
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.081723 (rank : 184)
Query Neighborhood Hits	157	Target Neighborhood Hits	246	Shared Neighborhood Hits	73
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.111884 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	226	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.082800 (rank : 183)
Query Neighborhood Hits	157	Target Neighborhood Hits	206	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH21A_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.062973 (rank : 219)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.068695 (rank : 209)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.093289 (rank : 165)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.092866 (rank : 167)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH23A_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.051378 (rank : 247)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH2D3_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.050378 (rank : 253)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.057546 (rank : 227)
Query Neighborhood Hits	157	Target Neighborhood Hits	174	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHAN2_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.054758 (rank : 234)
Query Neighborhood Hits	157	Target Neighborhood Hits	446	Shared Neighborhood Hits	74
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.070339 (rank : 205)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	43
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.073461 (rank : 198)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.065410 (rank : 212)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	46
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.064044 (rank : 217)
Query Neighborhood Hits	157	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.065337 (rank : 213)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.065936 (rank : 211)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.061933 (rank : 220)
Query Neighborhood Hits	157	Target Neighborhood Hits	155	Shared Neighborhood Hits	38
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.069253 (rank : 208)
Query Neighborhood Hits	157	Target Neighborhood Hits	151	Shared Neighborhood Hits	44
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.069964 (rank : 207)
Query Neighborhood Hits	157	Target Neighborhood Hits	204	Shared Neighborhood Hits	39
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.072860 (rank : 199)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.074744 (rank : 196)
Query Neighborhood Hits	157	Target Neighborhood Hits	164	Shared Neighborhood Hits	42
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.078524 (rank : 190)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.107519 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.108831 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.123415 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.120660 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.133329 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	139	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.130984 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.051125 (rank : 250)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX9_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.089562 (rank : 176)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.097898 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.113874 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.100500 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRC_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.100330 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	1058	Shared Neighborhood Hits	125
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.096097 (rank : 163)
Query Neighborhood Hits	157	Target Neighborhood Hits	1033	Shared Neighborhood Hits	119
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.097700 (rank : 158)
Query Neighborhood Hits	157	Target Neighborhood Hits	331	Shared Neighborhood Hits	102
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.159388 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	104
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.161902 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	232	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TCGAP_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.051164 (rank : 249)
Query Neighborhood Hits	157	Target Neighborhood Hits	872	Shared Neighborhood Hits	86
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.063862 (rank : 218)
Query Neighborhood Hits	157	Target Neighborhood Hits	409	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

YES_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.102507 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	1059	Shared Neighborhood Hits	122
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.102971 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	1052	Shared Neighborhood Hits	122
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

Hits sorted by NC score

EPS8_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_HUMAN
NC score	0.991035 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	151	Shared Neighborhood Hits	117
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L2_MOUSE
NC score	0.941175 (rank : 3)	θ value	1.43246e-122 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	105
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_HUMAN
NC score	0.940033 (rank : 4)	θ value	1.12714e-143 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	193	Shared Neighborhood Hits	110
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L1_MOUSE
NC score	0.932280 (rank : 5)	θ value	6.228e-118 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	143	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_HUMAN
NC score	0.929878 (rank : 6)	θ value	9.32813e-106 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L3_MOUSE
NC score	0.876447 (rank : 7)	θ value	3.36421e-55 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	168	Shared Neighborhood Hits	111
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_HUMAN
NC score	0.871577 (rank : 8)	θ value	1.41016e-61 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	206	Shared Neighborhood Hits	105
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NCK2_HUMAN
NC score	0.379859 (rank : 9)	θ value	5.26297e-08 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	310	Shared Neighborhood Hits	128
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.368442 (rank : 10)	θ value	8.97725e-08 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CRKL_HUMAN
NC score	0.343758 (rank : 11)	θ value	0.000121331 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	313	Shared Neighborhood Hits	125
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.342954 (rank : 12)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	122
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PPIP1_HUMAN
NC score	0.312976 (rank : 13)	θ value	0.000786445 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	389	Shared Neighborhood Hits	130
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP2_MOUSE
NC score	0.308035 (rank : 14)	θ value	0.000270298 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	297	Shared Neighborhood Hits	130
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CRK_MOUSE
NC score	0.307746 (rank : 15)	θ value	0.0113563 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	125
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP2_HUMAN
NC score	0.306967 (rank : 16)	θ value	0.00020696 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	304	Shared Neighborhood Hits	131
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRK_HUMAN
NC score	0.302420 (rank : 17)	θ value	0.0148317 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	308	Shared Neighborhood Hits	125
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NPHP1_MOUSE
NC score	0.301036 (rank : 18)	θ value	0.0252991 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	267	Shared Neighborhood Hits	124
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PPIP1_MOUSE
NC score	0.296124 (rank : 19)	θ value	0.00390308 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	377	Shared Neighborhood Hits	131
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

NPHP1_HUMAN
NC score	0.292539 (rank : 20)	θ value	0.0736092 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	288	Shared Neighborhood Hits	118
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

GRAP_HUMAN
NC score	0.292299 (rank : 21)	θ value	0.0431538 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	130
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRB2_HUMAN
NC score	0.288305 (rank : 22)	θ value	0.00298849 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	310	Shared Neighborhood Hits	129
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.287370 (rank : 23)	θ value	0.00298849 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP_MOUSE
NC score	0.283831 (rank : 24)	θ value	0.0113563 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	309	Shared Neighborhood Hits	128
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VINEX_MOUSE
NC score	0.275487 (rank : 25)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	286	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

STAM2_MOUSE
NC score	0.263976 (rank : 26)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	285	Shared Neighborhood Hits	124
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.260033 (rank : 27)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	288	Shared Neighborhood Hits	124
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM1_MOUSE
NC score	0.259662 (rank : 28)	θ value	0.365318 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	273	Shared Neighborhood Hits	123
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CD2AP_MOUSE
NC score	0.255747 (rank : 29)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	336	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NCF2_HUMAN
NC score	0.253152 (rank : 30)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	157	Target Neighborhood Hits	229	Shared Neighborhood Hits	112
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

STAM1_HUMAN
NC score	0.251171 (rank : 31)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	271	Shared Neighborhood Hits	124
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

VINEX_HUMAN
NC score	0.250129 (rank : 32)	θ value	0.0961366 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	270	Shared Neighborhood Hits	122
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

DNMBP_HUMAN
NC score	0.247903 (rank : 33)	θ value	0.0961366 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	413	Shared Neighborhood Hits	131
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CD2AP_HUMAN
NC score	0.236412 (rank : 34)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	315	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

DNMBP_MOUSE
NC score	0.236276 (rank : 35)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	435	Shared Neighborhood Hits	131
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SH3K1_MOUSE
NC score	0.228083 (rank : 36)	θ value	0.365318 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	332	Shared Neighborhood Hits	118
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

VAV_HUMAN
NC score	0.227378 (rank : 37)	θ value	0.00175202 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	452	Shared Neighborhood Hits	128
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SH3K1_HUMAN
NC score	0.224450 (rank : 38)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	341	Shared Neighborhood Hits	118
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

VAV_MOUSE
NC score	0.223825 (rank : 39)	θ value	0.00102713 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	430	Shared Neighborhood Hits	126
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SRBS1_MOUSE
NC score	0.217799 (rank : 40)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	409	Shared Neighborhood Hits	122
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SNX18_MOUSE
NC score	0.217558 (rank : 41)	θ value	0.00228821 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	98
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

AHI1_HUMAN
NC score	0.215678 (rank : 42)	θ value	0.0193708 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	537	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

NCF1_HUMAN
NC score	0.212396 (rank : 43)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	108
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SRBS1_HUMAN
NC score	0.209829 (rank : 44)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	396	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

AHI1_MOUSE
NC score	0.208777 (rank : 45)	θ value	0.0431538 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

EFS_MOUSE
NC score	0.207898 (rank : 46)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	389	Shared Neighborhood Hits	102
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ARHG7_MOUSE
NC score	0.207792 (rank : 47)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	396	Shared Neighborhood Hits	126
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SNX18_HUMAN
NC score	0.207745 (rank : 48)	θ value	0.00298849 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	207	Shared Neighborhood Hits	99
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHG6_MOUSE
NC score	0.206610 (rank : 49)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	394	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SH3G3_MOUSE
NC score	0.206147 (rank : 50)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	236	Shared Neighborhood Hits	117
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

STAC_HUMAN
NC score	0.205858 (rank : 51)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	276	Shared Neighborhood Hits	120
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BCAR1_MOUSE
NC score	0.203863 (rank : 52)	θ value	0.00665767 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	438	Shared Neighborhood Hits	113
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_HUMAN
NC score	0.196865 (rank : 53)	θ value	0.0252991 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	554	Shared Neighborhood Hits	115
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SH3G3_HUMAN
NC score	0.195094 (rank : 54)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	222	Shared Neighborhood Hits	112
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ARHG7_HUMAN
NC score	0.194709 (rank : 55)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	347	Shared Neighborhood Hits	122
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NCF1_MOUSE
NC score	0.193884 (rank : 56)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SH3G2_MOUSE
NC score	0.189677 (rank : 57)	θ value	2.36792 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	319	Shared Neighborhood Hits	117
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G2_HUMAN
NC score	0.189251 (rank : 58)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	324	Shared Neighborhood Hits	119
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

VAV3_HUMAN
NC score	0.188369 (rank : 59)	θ value	0.365318 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	398	Shared Neighborhood Hits	126
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SH3G1_HUMAN
NC score	0.186489 (rank : 60)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	116
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

PACN2_MOUSE
NC score	0.185613 (rank : 61)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

EFS_HUMAN
NC score	0.184715 (rank : 62)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	348	Shared Neighborhood Hits	102
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SH3G1_MOUSE
NC score	0.184569 (rank : 63)	θ value	4.03905 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	291	Shared Neighborhood Hits	119
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ARHG6_HUMAN
NC score	0.184012 (rank : 64)	θ value	0.813845 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	376	Shared Neighborhood Hits	118
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VAV3_MOUSE
NC score	0.180693 (rank : 65)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	404	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PACN2_HUMAN
NC score	0.178329 (rank : 66)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	339	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CIP4_HUMAN
NC score	0.176986 (rank : 67)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	374	Shared Neighborhood Hits	66
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

STAC_MOUSE
NC score	0.175511 (rank : 68)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	268	Shared Neighborhood Hits	116
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRC8_HUMAN
NC score	0.174785 (rank : 69)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	269	Shared Neighborhood Hits	120
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

VAV2_MOUSE
NC score	0.174697 (rank : 70)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	456	Shared Neighborhood Hits	124
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PACN1_HUMAN
NC score	0.174540 (rank : 71)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	157	Target Neighborhood Hits	320	Shared Neighborhood Hits	123
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

VAV2_HUMAN
NC score	0.173810 (rank : 72)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	453	Shared Neighborhood Hits	125
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ITSN2_HUMAN
NC score	0.170421 (rank : 73)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	1173	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SRC8_MOUSE
NC score	0.170180 (rank : 74)	θ value	2.36792 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	292	Shared Neighborhood Hits	121
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ITSN1_MOUSE
NC score	0.169457 (rank : 75)	θ value	0.00228821 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	1669	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PACN1_MOUSE
NC score	0.169263 (rank : 76)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	157	Target Neighborhood Hits	283	Shared Neighborhood Hits	122
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

HCLS1_HUMAN
NC score	0.167206 (rank : 77)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	358	Shared Neighborhood Hits	114
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
NC score	0.166546 (rank : 78)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	157	Target Neighborhood Hits	329	Shared Neighborhood Hits	115
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

OSTF1_HUMAN
NC score	0.165789 (rank : 79)	θ value	4.03905 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	466	Shared Neighborhood Hits	118
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

CASL_HUMAN
NC score	0.164751 (rank : 80)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	259	Shared Neighborhood Hits	102
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

STAC3_MOUSE
NC score	0.161902 (rank : 81)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	157	Target Neighborhood Hits	232	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ITSN1_HUMAN
NC score	0.161021 (rank : 82)	θ value	0.21417 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	1757	Shared Neighborhood Hits	137
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PACN3_HUMAN
NC score	0.161008 (rank : 83)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	157	Target Neighborhood Hits	385	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

CASL_MOUSE
NC score	0.160758 (rank : 84)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	225	Shared Neighborhood Hits	107
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

PACN3_MOUSE
NC score	0.160127 (rank : 85)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	157	Target Neighborhood Hits	380	Shared Neighborhood Hits	120
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

CT032_HUMAN
NC score	0.159630 (rank : 86)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	235	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

STAC3_HUMAN
NC score	0.159388 (rank : 87)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	104
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SPTA1_MOUSE
NC score	0.158639 (rank : 88)	θ value	0.00390308 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	675	Shared Neighborhood Hits	125
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ITSN2_MOUSE
NC score	0.158425 (rank : 89)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	1371	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

OSTF1_MOUSE
NC score	0.158130 (rank : 90)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	467	Shared Neighborhood Hits	119
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NCF4_MOUSE
NC score	0.157127 (rank : 91)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	177	Shared Neighborhood Hits	100
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI2_MOUSE
NC score	0.154452 (rank : 92)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	157	Target Neighborhood Hits	266	Shared Neighborhood Hits	110
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.153587 (rank : 93)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	157	Target Neighborhood Hits	350	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

DBNL_MOUSE
NC score	0.152960 (rank : 94)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	306	Shared Neighborhood Hits	106
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DBNL_HUMAN
NC score	0.151886 (rank : 95)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	244	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ASPP1_HUMAN
NC score	0.150914 (rank : 96)	θ value	0.0563607 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	956	Shared Neighborhood Hits	105
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NCF4_HUMAN
NC score	0.142455 (rank : 97)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	157	Target Neighborhood Hits	161	Shared Neighborhood Hits	90
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PLCG2_HUMAN
NC score	0.141781 (rank : 98)	θ value	3.0926 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	280	Shared Neighborhood Hits	112
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ASPP1_MOUSE
NC score	0.140632 (rank : 99)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	1244	Shared Neighborhood Hits	111
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ABI3_HUMAN
NC score	0.140080 (rank : 100)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	97
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
NC score	0.140071 (rank : 101)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	98
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI1_MOUSE
NC score	0.139756 (rank : 102)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	157	Target Neighborhood Hits	246	Shared Neighborhood Hits	107
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PLCG1_MOUSE
NC score	0.137277 (rank : 103)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	157	Target Neighborhood Hits	314	Shared Neighborhood Hits	113
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
NC score	0.135224 (rank : 104)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ARHG4_HUMAN
NC score	0.134750 (rank : 105)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	242	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SLAP2_HUMAN
NC score	0.133329 (rank : 106)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	157	Target Neighborhood Hits	139	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

ABI1_HUMAN
NC score	0.133154 (rank : 107)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	157	Target Neighborhood Hits	257	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SLAP2_MOUSE
NC score	0.130984 (rank : 108)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPTA1_HUMAN
NC score	0.130733 (rank : 109)	θ value	0.0563607 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	748	Shared Neighborhood Hits	125
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
NC score	0.129766 (rank : 110)	θ value	0.47712 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	888	Shared Neighborhood Hits	128
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

PEX13_MOUSE
NC score	0.124536 (rank : 111)	θ value	5.27518 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	126	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SLAP1_HUMAN
NC score	0.123415 (rank : 112)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

BTK_HUMAN
NC score	0.122981 (rank : 113)	θ value	0.00102713 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	1026	Shared Neighborhood Hits	127
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.121474 (rank : 114)	θ value	0.00228821 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	1017	Shared Neighborhood Hits	121
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

RHG04_HUMAN
NC score	0.120975 (rank : 115)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	108
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SLAP1_MOUSE
NC score	0.120660 (rank : 116)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

LASP1_HUMAN
NC score	0.119631 (rank : 117)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	103
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PEX13_HUMAN
NC score	0.119583 (rank : 118)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	157	Target Neighborhood Hits	128	Shared Neighborhood Hits	79
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

LASP1_MOUSE
NC score	0.117611 (rank : 119)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	157	Target Neighborhood Hits	297	Shared Neighborhood Hits	102
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ARHG9_MOUSE
NC score	0.116832 (rank : 120)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	234	Shared Neighborhood Hits	102
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

IASPP_HUMAN
NC score	0.114164 (rank : 121)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	157	Target Neighborhood Hits	688	Shared Neighborhood Hits	112
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SPN90_HUMAN
NC score	0.113874 (rank : 122)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

MYO1F_MOUSE
NC score	0.113495 (rank : 123)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	262	Shared Neighborhood Hits	121
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ARHG9_HUMAN
NC score	0.113224 (rank : 124)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	157	Target Neighborhood Hits	235	Shared Neighborhood Hits	101
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ANM2_MOUSE
NC score	0.112532 (rank : 125)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	105
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

MYO1F_HUMAN
NC score	0.112081 (rank : 126)	θ value	0.0148317 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	275	Shared Neighborhood Hits	121
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NOXO1_MOUSE
NC score	0.112046 (rank : 127)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	67
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

BLK_MOUSE
NC score	0.111917 (rank : 128)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	992	Shared Neighborhood Hits	94
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

RUSC1_HUMAN
NC score	0.111884 (rank : 129)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	157	Target Neighborhood Hits	226	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ANM2_HUMAN
NC score	0.111339 (rank : 130)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	103
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

HCK_HUMAN
NC score	0.111329 (rank : 131)	θ value	0.00175202 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	1035	Shared Neighborhood Hits	125
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FNBP2_HUMAN
NC score	0.111100 (rank : 132)	θ value	0.0193708 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	432	Shared Neighborhood Hits	103
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

BLK_HUMAN
NC score	0.110522 (rank : 133)	θ value	0.000786445 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	994	Shared Neighborhood Hits	103
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SHLB2_MOUSE
NC score	0.108831 (rank : 134)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	157	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

HCK_MOUSE
NC score	0.108504 (rank : 135)	θ value	0.00509761 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	1029	Shared Neighborhood Hits	125
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SHLB1_MOUSE
NC score	0.108201 (rank : 136)	θ value	3.0926 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
NC score	0.107519 (rank : 137)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	157	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

NEBL_HUMAN
NC score	0.106400 (rank : 138)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	157	Target Neighborhood Hits	457	Shared Neighborhood Hits	106
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

DDEF2_HUMAN
NC score	0.105706 (rank : 139)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	599	Shared Neighborhood Hits	101
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SHLB1_HUMAN
NC score	0.104682 (rank : 140)	θ value	5.27518 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

DDEF2_MOUSE
NC score	0.102991 (rank : 141)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	625	Shared Neighborhood Hits	102
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

YES_MOUSE
NC score	0.102971 (rank : 142)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	157	Target Neighborhood Hits	1052	Shared Neighborhood Hits	122
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

IASPP_MOUSE
NC score	0.102953 (rank : 143)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	157	Target Neighborhood Hits	1024	Shared Neighborhood Hits	116
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

FYN_MOUSE
NC score	0.102655 (rank : 144)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	157	Target Neighborhood Hits	1073	Shared Neighborhood Hits	125
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

YES_HUMAN
NC score	0.102507 (rank : 145)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	157	Target Neighborhood Hits	1059	Shared Neighborhood Hits	122
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SRGP1_HUMAN
NC score	0.101257 (rank : 146)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	390	Shared Neighborhood Hits	102
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FYN_HUMAN
NC score	0.101159 (rank : 147)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	157	Target Neighborhood Hits	1078	Shared Neighborhood Hits	125
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SPN90_MOUSE
NC score	0.100500 (rank : 148)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRC_HUMAN
NC score	0.100330 (rank : 149)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	157	Target Neighborhood Hits	1058	Shared Neighborhood Hits	125
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ARHG4_MOUSE
NC score	0.099765 (rank : 150)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	157	Target Neighborhood Hits	185	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGR_MOUSE
NC score	0.099545 (rank : 151)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	157	Target Neighborhood Hits	1069	Shared Neighborhood Hits	123
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRGP2_MOUSE
NC score	0.099342 (rank : 152)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	324	Shared Neighborhood Hits	103
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

DDEF1_MOUSE
NC score	0.099127 (rank : 153)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	157	Target Neighborhood Hits	592	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

TXK_MOUSE
NC score	0.098911 (rank : 154)	θ value	0.163984 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	980	Shared Neighborhood Hits	110
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ASPP2_HUMAN
NC score	0.098096 (rank : 155)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	157	Target Neighborhood Hits	1156	Shared Neighborhood Hits	97
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ITK_HUMAN
NC score	0.097981 (rank : 156)	θ value	0.125558 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	1016	Shared Neighborhood Hits	103
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SNX9_MOUSE
NC score	0.097898 (rank : 157)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SRGP2_HUMAN
NC score	0.097700 (rank : 158)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	157	Target Neighborhood Hits	331	Shared Neighborhood Hits	102
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

TEC_HUMAN
NC score	0.097243 (rank : 159)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	105
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MYO1E_HUMAN
NC score	0.097161 (rank : 160)	θ value	0.47712 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

TXK_HUMAN
NC score	0.096526 (rank : 161)	θ value	0.0563607 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	971	Shared Neighborhood Hits	104
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TEC_MOUSE
NC score	0.096474 (rank : 162)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	1006	Shared Neighborhood Hits	106
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SRC_MOUSE
NC score	0.096097 (rank : 163)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	157	Target Neighborhood Hits	1033	Shared Neighborhood Hits	119
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

NOXO1_HUMAN
NC score	0.094884 (rank : 164)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SH21B_HUMAN
NC score	0.093289 (rank : 165)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

NEBU_HUMAN
NC score	0.092952 (rank : 166)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	157	Target Neighborhood Hits	420	Shared Neighborhood Hits	110
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SH21B_MOUSE
NC score	0.092866 (rank : 167)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

FGR_HUMAN
NC score	0.092348 (rank : 168)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	157	Target Neighborhood Hits	1067	Shared Neighborhood Hits	120
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LYN_MOUSE
NC score	0.092175 (rank : 169)	θ value	0.0961366 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	1023	Shared Neighborhood Hits	110
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LCK_HUMAN
NC score	0.091967 (rank : 170)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	987	Shared Neighborhood Hits	89
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

RASA1_HUMAN
NC score	0.091044 (rank : 171)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	157	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

LYN_HUMAN
NC score	0.090846 (rank : 172)	θ value	0.279714 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	1022	Shared Neighborhood Hits	112
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LCK_MOUSE
NC score	0.090530 (rank : 173)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	981	Shared Neighborhood Hits	88
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

FRK_HUMAN
NC score	0.090297 (rank : 174)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	1058	Shared Neighborhood Hits	123
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

PTK6_MOUSE
NC score	0.089916 (rank : 175)	θ value	0.0961366 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	1026	Shared Neighborhood Hits	115
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SNX9_HUMAN
NC score	0.089562 (rank : 176)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

ITK_MOUSE
NC score	0.089513 (rank : 177)	θ value	0.21417 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	985	Shared Neighborhood Hits	91
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

RIMB2_HUMAN
NC score	0.086066 (rank : 178)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	157	Target Neighborhood Hits	263	Shared Neighborhood Hits	79
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

DAPP1_HUMAN
NC score	0.086025 (rank : 179)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ABL2_HUMAN
NC score	0.086007 (rank : 180)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	1045	Shared Neighborhood Hits	91
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

DAPP1_MOUSE
NC score	0.085636 (rank : 181)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	157	Target Neighborhood Hits	225	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PTK6_HUMAN
NC score	0.085626 (rank : 182)	θ value	0.365318 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	1020	Shared Neighborhood Hits	116
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RUSC1_MOUSE
NC score	0.082800 (rank : 183)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	157	Target Neighborhood Hits	206	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RIMB2_MOUSE
NC score	0.081723 (rank : 184)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	157	Target Neighborhood Hits	246	Shared Neighborhood Hits	73
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CSK_MOUSE
NC score	0.081690 (rank : 185)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	1009	Shared Neighborhood Hits	105
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.081501 (rank : 186)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	1009	Shared Neighborhood Hits	105
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ABL1_HUMAN
NC score	0.081234 (rank : 187)	θ value	3.0926 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	1220	Shared Neighborhood Hits	99
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.081015 (rank : 188)	θ value	3.0926 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	1178	Shared Neighborhood Hits	99
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

P85A_MOUSE
NC score	0.080395 (rank : 189)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	157	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHE_MOUSE
NC score	0.078524 (rank : 190)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

P85A_HUMAN
NC score	0.078113 (rank : 191)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	157	Target Neighborhood Hits	479	Shared Neighborhood Hits	76
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_MOUSE
NC score	0.075661 (rank : 192)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	157	Target Neighborhood Hits	519	Shared Neighborhood Hits	64
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

M3KL4_HUMAN
NC score	0.075289 (rank : 193)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	157	Target Neighborhood Hits	1087	Shared Neighborhood Hits	121
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

P85B_HUMAN
NC score	0.075258 (rank : 194)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	157	Target Neighborhood Hits	543	Shared Neighborhood Hits	64
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

HSH2D_HUMAN
NC score	0.075198 (rank : 195)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	157	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHE_HUMAN
NC score	0.074744 (rank : 196)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	157	Target Neighborhood Hits	164	Shared Neighborhood Hits	42
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SRMS_MOUSE
NC score	0.073681 (rank : 197)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	964	Shared Neighborhood Hits	80
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SHB_MOUSE
NC score	0.073461 (rank : 198)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_MOUSE
NC score	0.072860 (rank : 199)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

GRB14_MOUSE
NC score	0.072586 (rank : 200)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SRMS_HUMAN
NC score	0.072275 (rank : 201)	θ value	2.36792 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	946	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

P55G_HUMAN
NC score	0.071297 (rank : 202)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	157	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GRB14_HUMAN
NC score	0.071274 (rank : 203)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	42
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

P55G_MOUSE
NC score	0.070599 (rank : 204)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	157	Target Neighborhood Hits	401	Shared Neighborhood Hits	53
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHB_HUMAN
NC score	0.070339 (rank : 205)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	43
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

RHG26_HUMAN
NC score	0.070232 (rank : 206)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	157	Target Neighborhood Hits	281	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SHD_HUMAN
NC score	0.069964 (rank : 207)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	157	Target Neighborhood Hits	204	Shared Neighborhood Hits	39
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC3_MOUSE
NC score	0.069253 (rank : 208)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	157	Target Neighborhood Hits	151	Shared Neighborhood Hits	44
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SH21A_MOUSE
NC score	0.068695 (rank : 209)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

APS_HUMAN
NC score	0.066322 (rank : 210)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	40
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SHC2_MOUSE
NC score	0.065936 (rank : 211)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC1_HUMAN
NC score	0.065410 (rank : 212)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	46
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
NC score	0.065337 (rank : 213)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	157	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

LNK_HUMAN
NC score	0.064650 (rank : 214)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	157	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

GRB7_MOUSE
NC score	0.064480 (rank : 215)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LNK_MOUSE
NC score	0.064471 (rank : 216)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHC1_MOUSE
NC score	0.064044 (rank : 217)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	157	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

TCGAP_MOUSE
NC score	0.063862 (rank : 218)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	157	Target Neighborhood Hits	409	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SH21A_HUMAN
NC score	0.062973 (rank : 219)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	157	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SHC3_HUMAN
NC score	0.061933 (rank : 220)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	157	Target Neighborhood Hits	155	Shared Neighborhood Hits	38
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

M3K10_HUMAN
NC score	0.061786 (rank : 221)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	157	Target Neighborhood Hits	1071	Shared Neighborhood Hits	112
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K9_HUMAN
NC score	0.060317 (rank : 222)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	157	Target Neighborhood Hits	1123	Shared Neighborhood Hits	117
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K11_HUMAN
NC score	0.059225 (rank : 223)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	157	Target Neighborhood Hits	1136	Shared Neighborhood Hits	119
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

GRB7_HUMAN
NC score	0.058889 (rank : 224)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	157	Target Neighborhood Hits	156	Shared Neighborhood Hits	42
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

TFCP2_MOUSE
NC score	0.057921 (rank : 225)	θ value	0.21417 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERA0, Q3UGJ4, Q8VC13	Gene names	Tcfcp2
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2.

TFCP2_HUMAN
NC score	0.057884 (rank : 226)	θ value	0.21417 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q12800, Q12801, Q9UD77	Gene names	TFCP2, LSF, SEF
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2 (Transcription factor LSF) (SAA3 enhancer factor).

SH2D3_MOUSE
NC score	0.057546 (rank : 227)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	157	Target Neighborhood Hits	174	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

MATK_MOUSE
NC score	0.056845 (rank : 228)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	157	Target Neighborhood Hits	952	Shared Neighborhood Hits	67
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MATK_HUMAN
NC score	0.056837 (rank : 229)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	157	Target Neighborhood Hits	954	Shared Neighborhood Hits	62
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ARHG5_HUMAN
NC score	0.056149 (rank : 230)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	157	Target Neighborhood Hits	172	Shared Neighborhood Hits	59
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

DOCK1_HUMAN
NC score	0.055457 (rank : 231)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	191	Shared Neighborhood Hits	77
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

NGEF_MOUSE
NC score	0.055011 (rank : 232)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

HSH2D_MOUSE
NC score	0.054978 (rank : 233)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	157	Target Neighborhood Hits	124	Shared Neighborhood Hits	30
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHAN2_MOUSE
NC score	0.054758 (rank : 234)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	157	Target Neighborhood Hits	446	Shared Neighborhood Hits	74
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

MCF2L_MOUSE
NC score	0.054705 (rank : 235)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	157	Target Neighborhood Hits	255	Shared Neighborhood Hits	36
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

RIMB1_HUMAN
NC score	0.054643 (rank : 236)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	157	Target Neighborhood Hits	1479	Shared Neighborhood Hits	98
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

NGEF_HUMAN
NC score	0.054155 (rank : 237)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	157	Target Neighborhood Hits	166	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RIMB1_MOUSE
NC score	0.053426 (rank : 238)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	157	Target Neighborhood Hits	1376	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

APS_MOUSE
NC score	0.053365 (rank : 239)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	157	Target Neighborhood Hits	134	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

PTN11_MOUSE
NC score	0.053308 (rank : 240)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.053300 (rank : 241)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	157	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

GRB10_MOUSE
NC score	0.053235 (rank : 242)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	157	Target Neighborhood Hits	156	Shared Neighborhood Hits	42
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB10_HUMAN
NC score	0.052603 (rank : 243)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	157	Target Neighborhood Hits	147	Shared Neighborhood Hits	40
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

PKHG1_HUMAN
NC score	0.051767 (rank : 244)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	157	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

BCAR3_HUMAN
NC score	0.051702 (rank : 245)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	157	Target Neighborhood Hits	129	Shared Neighborhood Hits	31
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BMX_MOUSE
NC score	0.051379 (rank : 246)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	157	Target Neighborhood Hits	912	Shared Neighborhood Hits	44
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

SH23A_HUMAN
NC score	0.051378 (rank : 247)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

BCAR3_MOUSE
NC score	0.051346 (rank : 248)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	157	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

TCGAP_HUMAN
NC score	0.051164 (rank : 249)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	157	Target Neighborhood Hits	872	Shared Neighborhood Hits	86
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SLY_MOUSE
NC score	0.051125 (rank : 250)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

BMX_HUMAN
NC score	0.050970 (rank : 251)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	157	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

FER_HUMAN
NC score	0.050884 (rank : 252)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	157	Target Neighborhood Hits	1278	Shared Neighborhood Hits	59
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SH2D3_HUMAN
NC score	0.050378 (rank : 253)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

RUSC2_MOUSE
NC score	0.048054 (rank : 254)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TRIO_HUMAN
NC score	0.042432 (rank : 255)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	1580	Shared Neighborhood Hits	74
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARH_MOUSE
NC score	0.025193 (rank : 256)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

TOM1_HUMAN
NC score	0.021625 (rank : 257)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	O60784, Q5TIJ6	Gene names	TOM1
Domain Architecture
Description	Target of Myb protein 1.

ARH_HUMAN
NC score	0.019944 (rank : 258)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

CD2L7_HUMAN
NC score	0.018317 (rank : 259)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	1275	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

MEPE_HUMAN
NC score	0.015153 (rank : 260)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

MINT_MOUSE
NC score	0.015009 (rank : 261)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	1514	Shared Neighborhood Hits	23
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NCOR2_MOUSE
NC score	0.011908 (rank : 262)	θ value	3.0926 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	790	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NOS3_MOUSE
NC score	0.010165 (rank : 263)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	63	Shared Neighborhood Hits	5
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

NOS3_HUMAN
NC score	0.009964 (rank : 264)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

FA53B_HUMAN
NC score	0.009200 (rank : 265)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q14153, Q8N5S6	Gene names	FAM53B, KIAA0140
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

CYTSA_HUMAN
NC score	0.007547 (rank : 266)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	1138	Shared Neighborhood Hits	20
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

GAB1_HUMAN
NC score	0.007274 (rank : 267)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

TR19L_HUMAN
NC score	0.007177 (rank : 268)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q969Z4, Q86V34, Q96JU1, Q9BUX7	Gene names	TNFRSF19L, RELT
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19L precursor (Receptor expressed in lymphoid tissues).

USH1C_MOUSE
NC score	0.006932 (rank : 269)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	557	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PAX3_HUMAN
NC score	0.006414 (rank : 270)	θ value	3.0926 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	513	Shared Neighborhood Hits	5
SwissProt Accessions	P23760, Q16448	Gene names	PAX3, HUP2
Domain Architecture
Description	Paired box protein Pax-3 (HUP2).

DAF1_MOUSE
NC score	0.005884 (rank : 271)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

PDLI7_HUMAN
NC score	0.004903 (rank : 272)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	547	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SCNNB_HUMAN
NC score	0.004610 (rank : 273)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P51168, O60891, Q96KG2, Q9UJ32, Q9UMU5	Gene names	SCNN1B
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH) (ENaCB).

KIF5C_MOUSE
NC score	0.003596 (rank : 274)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	1040	Shared Neighborhood Hits	25
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

SPR1A_MOUSE
NC score	0.003302 (rank : 275)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

ABCA7_HUMAN
NC score	0.002477 (rank : 276)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	144	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

DDX31_HUMAN
NC score	0.002044 (rank : 277)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

GLI3_HUMAN
NC score	-0.002950 (rank : 278)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	871	Shared Neighborhood Hits	5
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.