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Network neighborhood for query Sequence : SLY_MOUSE

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SLY_MOUSE
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SLY_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SLY_HUMAN
θ value	4.24358e-175 (rank : 2)	NC score	0.990636 (rank : 2)
Query Neighborhood Hits	108	Target Neighborhood Hits	81	Shared Neighborhood Hits	68
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SASH1_HUMAN
θ value	6.32992e-62 (rank : 3)	NC score	0.838390 (rank : 5)
Query Neighborhood Hits	108	Target Neighborhood Hits	292	Shared Neighborhood Hits	63
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SAMN1_MOUSE
θ value	2.40537e-61 (rank : 4)	NC score	0.929349 (rank : 3)
Query Neighborhood Hits	108	Target Neighborhood Hits	69	Shared Neighborhood Hits	49
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_MOUSE
θ value	1.55911e-60 (rank : 5)	NC score	0.833082 (rank : 6)
Query Neighborhood Hits	108	Target Neighborhood Hits	263	Shared Neighborhood Hits	62
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SAMN1_HUMAN
θ value	2.32979e-56 (rank : 6)	NC score	0.922484 (rank : 4)
Query Neighborhood Hits	108	Target Neighborhood Hits	74	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

ANKS1_HUMAN
θ value	1.69304e-06 (rank : 7)	NC score	0.143449 (rank : 45)
Query Neighborhood Hits	108	Target Neighborhood Hits	438	Shared Neighborhood Hits	17
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	1.69304e-06 (rank : 8)	NC score	0.149412 (rank : 37)
Query Neighborhood Hits	108	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

CD2AP_MOUSE
θ value	0.00020696 (rank : 9)	NC score	0.262494 (rank : 10)
Query Neighborhood Hits	108	Target Neighborhood Hits	336	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_HUMAN
θ value	0.000270298 (rank : 10)	NC score	0.274926 (rank : 8)
Query Neighborhood Hits	108	Target Neighborhood Hits	341	Shared Neighborhood Hits	66
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.000270298 (rank : 11)	NC score	0.272293 (rank : 9)
Query Neighborhood Hits	108	Target Neighborhood Hits	332	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CRK_MOUSE
θ value	0.000461057 (rank : 12)	NC score	0.258687 (rank : 11)
Query Neighborhood Hits	108	Target Neighborhood Hits	314	Shared Neighborhood Hits	66
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
θ value	0.00175202 (rank : 13)	NC score	0.246439 (rank : 13)
Query Neighborhood Hits	108	Target Neighborhood Hits	313	Shared Neighborhood Hits	67
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	0.00175202 (rank : 14)	NC score	0.245923 (rank : 14)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	0.00228821 (rank : 15)	NC score	0.249913 (rank : 12)
Query Neighborhood Hits	108	Target Neighborhood Hits	308	Shared Neighborhood Hits	67
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MYO1E_HUMAN
θ value	0.00298849 (rank : 16)	NC score	0.117280 (rank : 70)
Query Neighborhood Hits	108	Target Neighborhood Hits	293	Shared Neighborhood Hits	64
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	0.00665767 (rank : 17)	NC score	0.103746 (rank : 81)
Query Neighborhood Hits	108	Target Neighborhood Hits	275	Shared Neighborhood Hits	67
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

CD2AP_HUMAN
θ value	0.00869519 (rank : 18)	NC score	0.296477 (rank : 7)
Query Neighborhood Hits	108	Target Neighborhood Hits	315	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ITSN1_HUMAN
θ value	0.00869519 (rank : 19)	NC score	0.132432 (rank : 55)
Query Neighborhood Hits	108	Target Neighborhood Hits	1757	Shared Neighborhood Hits	72
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VINEX_HUMAN
θ value	0.00869519 (rank : 20)	NC score	0.201060 (rank : 16)
Query Neighborhood Hits	108	Target Neighborhood Hits	270	Shared Neighborhood Hits	61
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	0.0252991 (rank : 21)	NC score	0.194278 (rank : 20)
Query Neighborhood Hits	108	Target Neighborhood Hits	286	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ARHG6_MOUSE
θ value	0.0431538 (rank : 22)	NC score	0.201013 (rank : 17)
Query Neighborhood Hits	108	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ABI2_MOUSE
θ value	0.0563607 (rank : 23)	NC score	0.169097 (rank : 28)
Query Neighborhood Hits	108	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CSKI1_MOUSE
θ value	0.0563607 (rank : 24)	NC score	0.088769 (rank : 98)
Query Neighborhood Hits	108	Target Neighborhood Hits	1031	Shared Neighborhood Hits	42
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

GRAP_MOUSE
θ value	0.0563607 (rank : 25)	NC score	0.180090 (rank : 25)
Query Neighborhood Hits	108	Target Neighborhood Hits	309	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CSKI1_HUMAN
θ value	0.0736092 (rank : 26)	NC score	0.087936 (rank : 99)
Query Neighborhood Hits	108	Target Neighborhood Hits	997	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SH3G2_MOUSE
θ value	0.0736092 (rank : 27)	NC score	0.174163 (rank : 27)
Query Neighborhood Hits	108	Target Neighborhood Hits	319	Shared Neighborhood Hits	63
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABI2_HUMAN
θ value	0.0961366 (rank : 28)	NC score	0.166403 (rank : 30)
Query Neighborhood Hits	108	Target Neighborhood Hits	350	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ARHG7_HUMAN
θ value	0.0961366 (rank : 29)	NC score	0.197092 (rank : 18)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	0.125558 (rank : 30)	NC score	0.195049 (rank : 19)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

TCF20_MOUSE
θ value	0.125558 (rank : 31)	NC score	0.052848 (rank : 151)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

VAV_MOUSE
θ value	0.125558 (rank : 32)	NC score	0.168195 (rank : 29)
Query Neighborhood Hits	108	Target Neighborhood Hits	430	Shared Neighborhood Hits	63
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GRAP_HUMAN
θ value	0.163984 (rank : 33)	NC score	0.188082 (rank : 21)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ARHG6_HUMAN
θ value	0.21417 (rank : 34)	NC score	0.203419 (rank : 15)
Query Neighborhood Hits	108	Target Neighborhood Hits	376	Shared Neighborhood Hits	63
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

NCK2_HUMAN
θ value	0.21417 (rank : 35)	NC score	0.177623 (rank : 26)
Query Neighborhood Hits	108	Target Neighborhood Hits	310	Shared Neighborhood Hits	63
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ITSN1_MOUSE
θ value	0.279714 (rank : 36)	NC score	0.122942 (rank : 63)
Query Neighborhood Hits	108	Target Neighborhood Hits	1669	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NPHP1_MOUSE
θ value	0.279714 (rank : 37)	NC score	0.146424 (rank : 42)
Query Neighborhood Hits	108	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SH3G2_HUMAN
θ value	0.279714 (rank : 38)	NC score	0.160295 (rank : 32)
Query Neighborhood Hits	108	Target Neighborhood Hits	324	Shared Neighborhood Hits	59
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

VAV3_MOUSE
θ value	0.279714 (rank : 39)	NC score	0.147161 (rank : 41)
Query Neighborhood Hits	108	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	0.365318 (rank : 40)	NC score	0.165787 (rank : 31)
Query Neighborhood Hits	108	Target Neighborhood Hits	452	Shared Neighborhood Hits	60
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ITSN2_HUMAN
θ value	0.47712 (rank : 41)	NC score	0.124513 (rank : 61)
Query Neighborhood Hits	108	Target Neighborhood Hits	1173	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV3_HUMAN
θ value	0.62314 (rank : 42)	NC score	0.149247 (rank : 38)
Query Neighborhood Hits	108	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CSKP_MOUSE
θ value	0.813845 (rank : 43)	NC score	0.020840 (rank : 166)
Query Neighborhood Hits	108	Target Neighborhood Hits	1027	Shared Neighborhood Hits	52
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

M3K11_HUMAN
θ value	0.813845 (rank : 44)	NC score	0.039103 (rank : 156)
Query Neighborhood Hits	108	Target Neighborhood Hits	1136	Shared Neighborhood Hits	63
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MYO1F_MOUSE
θ value	0.813845 (rank : 45)	NC score	0.086647 (rank : 101)
Query Neighborhood Hits	108	Target Neighborhood Hits	262	Shared Neighborhood Hits	63
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NPHP1_HUMAN
θ value	0.813845 (rank : 46)	NC score	0.125773 (rank : 60)
Query Neighborhood Hits	108	Target Neighborhood Hits	288	Shared Neighborhood Hits	52
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SCNNB_HUMAN
θ value	0.813845 (rank : 47)	NC score	0.022190 (rank : 164)
Query Neighborhood Hits	108	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P51168, O60891, Q96KG2, Q9UJ32, Q9UMU5	Gene names	SCNN1B
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH) (ENaCB).

TCF20_HUMAN
θ value	0.813845 (rank : 48)	NC score	0.046508 (rank : 155)
Query Neighborhood Hits	108	Target Neighborhood Hits	323	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

VAV2_HUMAN
θ value	0.813845 (rank : 49)	NC score	0.137066 (rank : 51)
Query Neighborhood Hits	108	Target Neighborhood Hits	453	Shared Neighborhood Hits	58
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CSKP_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.021426 (rank : 165)
Query Neighborhood Hits	108	Target Neighborhood Hits	1022	Shared Neighborhood Hits	49
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

ITSN2_MOUSE
θ value	1.06291 (rank : 51)	NC score	0.118886 (rank : 69)
Query Neighborhood Hits	108	Target Neighborhood Hits	1371	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SH3G3_MOUSE
θ value	1.06291 (rank : 52)	NC score	0.183464 (rank : 22)
Query Neighborhood Hits	108	Target Neighborhood Hits	236	Shared Neighborhood Hits	63
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PF21A_HUMAN
θ value	1.38821 (rank : 53)	NC score	0.025155 (rank : 161)
Query Neighborhood Hits	108	Target Neighborhood Hits	303	Shared Neighborhood Hits	4
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

TLE2_MOUSE
θ value	1.38821 (rank : 54)	NC score	0.015150 (rank : 173)
Query Neighborhood Hits	108	Target Neighborhood Hits	294	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

CSKI2_MOUSE
θ value	1.81305 (rank : 55)	NC score	0.077629 (rank : 115)
Query Neighborhood Hits	108	Target Neighborhood Hits	812	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GRAP2_MOUSE
θ value	1.81305 (rank : 56)	NC score	0.151418 (rank : 36)
Query Neighborhood Hits	108	Target Neighborhood Hits	297	Shared Neighborhood Hits	65
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

LAMA3_MOUSE
θ value	1.81305 (rank : 57)	NC score	0.011909 (rank : 178)
Query Neighborhood Hits	108	Target Neighborhood Hits	859	Shared Neighborhood Hits	10
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

M3KL4_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.035552 (rank : 157)
Query Neighborhood Hits	108	Target Neighborhood Hits	1087	Shared Neighborhood Hits	58
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

OSTF1_MOUSE
θ value	1.81305 (rank : 59)	NC score	0.134682 (rank : 54)
Query Neighborhood Hits	108	Target Neighborhood Hits	467	Shared Neighborhood Hits	66
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PF21A_MOUSE
θ value	1.81305 (rank : 60)	NC score	0.024812 (rank : 162)
Query Neighborhood Hits	108	Target Neighborhood Hits	285	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

TLE2_HUMAN
θ value	1.81305 (rank : 61)	NC score	0.015760 (rank : 172)
Query Neighborhood Hits	108	Target Neighborhood Hits	321	Shared Neighborhood Hits	5
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

VAV2_MOUSE
θ value	1.81305 (rank : 62)	NC score	0.135921 (rank : 52)
Query Neighborhood Hits	108	Target Neighborhood Hits	456	Shared Neighborhood Hits	58
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ABI3_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.130495 (rank : 57)
Query Neighborhood Hits	108	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

GOGA3_HUMAN
θ value	2.36792 (rank : 64)	NC score	0.006671 (rank : 188)
Query Neighborhood Hits	108	Target Neighborhood Hits	1317	Shared Neighborhood Hits	11
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

NCK1_HUMAN
θ value	2.36792 (rank : 65)	NC score	0.147705 (rank : 40)
Query Neighborhood Hits	108	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

OSTF1_HUMAN
θ value	2.36792 (rank : 66)	NC score	0.135047 (rank : 53)
Query Neighborhood Hits	108	Target Neighborhood Hits	466	Shared Neighborhood Hits	66
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3G1_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.146173 (rank : 43)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	2.36792 (rank : 68)	NC score	0.148532 (rank : 39)
Query Neighborhood Hits	108	Target Neighborhood Hits	291	Shared Neighborhood Hits	60
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SRBS1_HUMAN
θ value	2.36792 (rank : 69)	NC score	0.183152 (rank : 23)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ZBT40_HUMAN
θ value	2.36792 (rank : 70)	NC score	-0.000325 (rank : 196)
Query Neighborhood Hits	108	Target Neighborhood Hits	949	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

ZN192_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.000268 (rank : 195)
Query Neighborhood Hits	108	Target Neighborhood Hits	789	Shared Neighborhood Hits	5
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).

GRAP2_HUMAN
θ value	3.0926 (rank : 72)	NC score	0.142746 (rank : 46)
Query Neighborhood Hits	108	Target Neighborhood Hits	304	Shared Neighborhood Hits	65
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

KBTBB_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.010013 (rank : 180)
Query Neighborhood Hits	108	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

M3K12_HUMAN
θ value	3.0926 (rank : 74)	NC score	0.003368 (rank : 193)
Query Neighborhood Hits	108	Target Neighborhood Hits	940	Shared Neighborhood Hits	8
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

PAX5_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.017036 (rank : 170)
Query Neighborhood Hits	108	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q02548, O75933	Gene names	PAX5
Domain Architecture
Description	Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP).

PLCG1_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.108844 (rank : 78)
Query Neighborhood Hits	108	Target Neighborhood Hits	293	Shared Neighborhood Hits	53
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	3.0926 (rank : 77)	NC score	0.110753 (rank : 75)
Query Neighborhood Hits	108	Target Neighborhood Hits	314	Shared Neighborhood Hits	56
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRBS1_MOUSE
θ value	3.0926 (rank : 78)	NC score	0.182512 (rank : 24)
Query Neighborhood Hits	108	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC_MOUSE
θ value	3.0926 (rank : 79)	NC score	0.152199 (rank : 35)
Query Neighborhood Hits	108	Target Neighborhood Hits	268	Shared Neighborhood Hits	64
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

COGA1_HUMAN
θ value	5.27518 (rank : 80)	NC score	0.005407 (rank : 191)
Query Neighborhood Hits	108	Target Neighborhood Hits	345	Shared Neighborhood Hits	3
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

CSKI2_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.074325 (rank : 117)
Query Neighborhood Hits	108	Target Neighborhood Hits	747	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA2_MOUSE
θ value	5.27518 (rank : 82)	NC score	0.014303 (rank : 174)
Query Neighborhood Hits	108	Target Neighborhood Hits	1020	Shared Neighborhood Hits	20
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FRDA_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.029966 (rank : 158)
Query Neighborhood Hits	108	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q16595, O15545, O95656, Q15294	Gene names	FXN, FRDA, X25
Domain Architecture
Description	Frataxin, mitochondrial precursor (Friedreich ataxia protein) (Fxn) [Contains: Frataxin intermediate form].

GP152_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.006924 (rank : 187)
Query Neighborhood Hits	108	Target Neighborhood Hits	636	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

NCF1_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.138688 (rank : 47)
Query Neighborhood Hits	108	Target Neighborhood Hits	198	Shared Neighborhood Hits	56
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SRRM2_HUMAN
θ value	5.27518 (rank : 86)	NC score	0.024800 (rank : 163)
Query Neighborhood Hits	108	Target Neighborhood Hits	1296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

UN119_HUMAN
θ value	5.27518 (rank : 87)	NC score	0.018753 (rank : 169)
Query Neighborhood Hits	108	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q13432, O95126	Gene names	UNC119, RG4
Domain Architecture
Description	Unc-119 protein homolog (Retinal protein 4) (HRG4).

AKTS1_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.016365 (rank : 171)
Query Neighborhood Hits	108	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B36, Q96BI4, Q96IK7, Q96NG2, Q9BWR5	Gene names	AKT1S1, PRAS40
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate).

CABIN_HUMAN
θ value	6.88961 (rank : 89)	NC score	0.020271 (rank : 167)
Query Neighborhood Hits	108	Target Neighborhood Hits	490	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

KCNH3_MOUSE
θ value	6.88961 (rank : 90)	NC score	0.004987 (rank : 192)
Query Neighborhood Hits	108	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

N4BP3_HUMAN
θ value	6.88961 (rank : 91)	NC score	0.012119 (rank : 177)
Query Neighborhood Hits	108	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	O15049, Q7Z6I3	Gene names	N4BP3, KIAA0341
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

RUSC1_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.065683 (rank : 126)
Query Neighborhood Hits	108	Target Neighborhood Hits	226	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

STAC_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.155430 (rank : 33)
Query Neighborhood Hits	108	Target Neighborhood Hits	276	Shared Neighborhood Hits	65
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SYNE2_HUMAN
θ value	6.88961 (rank : 94)	NC score	0.006346 (rank : 190)
Query Neighborhood Hits	108	Target Neighborhood Hits	1323	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TERF2_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.018984 (rank : 168)
Query Neighborhood Hits	108	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

ZCHC8_MOUSE
θ value	6.88961 (rank : 96)	NC score	0.012897 (rank : 175)
Query Neighborhood Hits	108	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYA6, Q3TK71, Q8CCB7, Q91WQ1	Gene names	Zcchc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

ADDA_HUMAN
θ value	8.99809 (rank : 97)	NC score	0.006566 (rank : 189)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	3
SwissProt Accessions	P35611, Q13734, Q14729, Q16156, Q9UJB6	Gene names	ADD1, ADDA
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

CEND1_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.026789 (rank : 159)
Query Neighborhood Hits	108	Target Neighborhood Hits	284	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

EPHA2_HUMAN
θ value	8.99809 (rank : 99)	NC score	0.012641 (rank : 176)
Query Neighborhood Hits	108	Target Neighborhood Hits	1021	Shared Neighborhood Hits	21
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

NMDE4_HUMAN
θ value	8.99809 (rank : 100)	NC score	0.003336 (rank : 194)
Query Neighborhood Hits	108	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

PAX5_MOUSE
θ value	8.99809 (rank : 101)	NC score	0.010107 (rank : 179)
Query Neighborhood Hits	108	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q02650	Gene names	Pax5, Pax-5
Domain Architecture
Description	Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP).

PJA1_HUMAN
θ value	8.99809 (rank : 102)	NC score	0.007983 (rank : 185)
Query Neighborhood Hits	108	Target Neighborhood Hits	159	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NG27, Q8NG28, Q9HAC1	Gene names	PJA1, RNF70
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-) (RING finger protein 70).

RAIN_MOUSE
θ value	8.99809 (rank : 103)	NC score	0.008647 (rank : 182)
Query Neighborhood Hits	108	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RTN1_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.009028 (rank : 181)
Query Neighborhood Hits	108	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

SRRM2_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.026026 (rank : 160)
Query Neighborhood Hits	108	Target Neighborhood Hits	1470	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SYP2L_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.007253 (rank : 186)
Query Neighborhood Hits	108	Target Neighborhood Hits	400	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TWST2_HUMAN
θ value	8.99809 (rank : 107)	NC score	0.008227 (rank : 184)
Query Neighborhood Hits	108	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
θ value	8.99809 (rank : 108)	NC score	0.008243 (rank : 183)
Query Neighborhood Hits	108	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

ABI1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.129627 (rank : 58)
Query Neighborhood Hits	108	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.132111 (rank : 56)
Query Neighborhood Hits	108	Target Neighborhood Hits	246	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.119828 (rank : 68)
Query Neighborhood Hits	108	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.084035 (rank : 105)
Query Neighborhood Hits	108	Target Neighborhood Hits	537	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.081687 (rank : 107)
Query Neighborhood Hits	108	Target Neighborhood Hits	496	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.054467 (rank : 148)
Query Neighborhood Hits	108	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.051550 (rank : 152)
Query Neighborhood Hits	108	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG4_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.092325 (rank : 92)
Query Neighborhood Hits	108	Target Neighborhood Hits	242	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.086492 (rank : 102)
Query Neighborhood Hits	108	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.058436 (rank : 136)
Query Neighborhood Hits	108	Target Neighborhood Hits	172	Shared Neighborhood Hits	45
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG9_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.085278 (rank : 103)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.084806 (rank : 104)
Query Neighborhood Hits	108	Target Neighborhood Hits	234	Shared Neighborhood Hits	54
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.056496 (rank : 141)
Query Neighborhood Hits	108	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.057405 (rank : 139)
Query Neighborhood Hits	108	Target Neighborhood Hits	1244	Shared Neighborhood Hits	63
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.054726 (rank : 146)
Query Neighborhood Hits	108	Target Neighborhood Hits	1156	Shared Neighborhood Hits	60
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCAR1_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.080662 (rank : 109)
Query Neighborhood Hits	108	Target Neighborhood Hits	554	Shared Neighborhood Hits	58
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.083158 (rank : 106)
Query Neighborhood Hits	108	Target Neighborhood Hits	438	Shared Neighborhood Hits	57
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.077886 (rank : 114)
Query Neighborhood Hits	108	Target Neighborhood Hits	259	Shared Neighborhood Hits	56
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.081425 (rank : 108)
Query Neighborhood Hits	108	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CT032_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.095620 (rank : 86)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.100670 (rank : 82)
Query Neighborhood Hits	108	Target Neighborhood Hits	244	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.098997 (rank : 85)
Query Neighborhood Hits	108	Target Neighborhood Hits	306	Shared Neighborhood Hits	54
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.068418 (rank : 124)
Query Neighborhood Hits	108	Target Neighborhood Hits	592	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.060932 (rank : 130)
Query Neighborhood Hits	108	Target Neighborhood Hits	599	Shared Neighborhood Hits	58
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.062124 (rank : 128)
Query Neighborhood Hits	108	Target Neighborhood Hits	625	Shared Neighborhood Hits	61
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DNMBP_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.121162 (rank : 66)
Query Neighborhood Hits	108	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.123706 (rank : 62)
Query Neighborhood Hits	108	Target Neighborhood Hits	435	Shared Neighborhood Hits	61
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EFS_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.072437 (rank : 119)
Query Neighborhood Hits	108	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.078509 (rank : 112)
Query Neighborhood Hits	108	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EPS8_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.055596 (rank : 144)
Query Neighborhood Hits	108	Target Neighborhood Hits	151	Shared Neighborhood Hits	47
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.051125 (rank : 153)
Query Neighborhood Hits	108	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L3_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.060494 (rank : 131)
Query Neighborhood Hits	108	Target Neighborhood Hits	168	Shared Neighborhood Hits	50
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FNBP2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.054110 (rank : 150)
Query Neighborhood Hits	108	Target Neighborhood Hits	432	Shared Neighborhood Hits	55
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRB2_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.138405 (rank : 49)
Query Neighborhood Hits	108	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.138126 (rank : 50)
Query Neighborhood Hits	108	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.122469 (rank : 64)
Query Neighborhood Hits	108	Target Neighborhood Hits	358	Shared Neighborhood Hits	59
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.117037 (rank : 71)
Query Neighborhood Hits	108	Target Neighborhood Hits	329	Shared Neighborhood Hits	57
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.061160 (rank : 129)
Query Neighborhood Hits	108	Target Neighborhood Hits	688	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.060299 (rank : 132)
Query Neighborhood Hits	108	Target Neighborhood Hits	1024	Shared Neighborhood Hits	64
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.093196 (rank : 91)
Query Neighborhood Hits	108	Target Neighborhood Hits	293	Shared Neighborhood Hits	54
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.093709 (rank : 90)
Query Neighborhood Hits	108	Target Neighborhood Hits	297	Shared Neighborhood Hits	55
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCF1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.138672 (rank : 48)
Query Neighborhood Hits	108	Target Neighborhood Hits	198	Shared Neighborhood Hits	57
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.152450 (rank : 34)
Query Neighborhood Hits	108	Target Neighborhood Hits	229	Shared Neighborhood Hits	59
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.121896 (rank : 65)
Query Neighborhood Hits	108	Target Neighborhood Hits	161	Shared Neighborhood Hits	50
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.125788 (rank : 59)
Query Neighborhood Hits	108	Target Neighborhood Hits	177	Shared Neighborhood Hits	54
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.087350 (rank : 100)
Query Neighborhood Hits	108	Target Neighborhood Hits	457	Shared Neighborhood Hits	55
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.071675 (rank : 120)
Query Neighborhood Hits	108	Target Neighborhood Hits	420	Shared Neighborhood Hits	54
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.055724 (rank : 143)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.058517 (rank : 134)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.069119 (rank : 122)
Query Neighborhood Hits	108	Target Neighborhood Hits	100	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.090305 (rank : 96)
Query Neighborhood Hits	108	Target Neighborhood Hits	114	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACN1_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.091897 (rank : 93)
Query Neighborhood Hits	108	Target Neighborhood Hits	320	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.090812 (rank : 94)
Query Neighborhood Hits	108	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.094781 (rank : 89)
Query Neighborhood Hits	108	Target Neighborhood Hits	339	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.095111 (rank : 88)
Query Neighborhood Hits	108	Target Neighborhood Hits	382	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.090481 (rank : 95)
Query Neighborhood Hits	108	Target Neighborhood Hits	385	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.089896 (rank : 97)
Query Neighborhood Hits	108	Target Neighborhood Hits	380	Shared Neighborhood Hits	57
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.068915 (rank : 123)
Query Neighborhood Hits	108	Target Neighborhood Hits	128	Shared Neighborhood Hits	39
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.070849 (rank : 121)
Query Neighborhood Hits	108	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.054607 (rank : 147)
Query Neighborhood Hits	108	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG2_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.095478 (rank : 87)
Query Neighborhood Hits	108	Target Neighborhood Hits	280	Shared Neighborhood Hits	55
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.112347 (rank : 74)
Query Neighborhood Hits	108	Target Neighborhood Hits	389	Shared Neighborhood Hits	56
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.110258 (rank : 77)
Query Neighborhood Hits	108	Target Neighborhood Hits	377	Shared Neighborhood Hits	55
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RHG04_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.067607 (rank : 125)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.055945 (rank : 142)
Query Neighborhood Hits	108	Target Neighborhood Hits	281	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB2_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.078348 (rank : 113)
Query Neighborhood Hits	108	Target Neighborhood Hits	263	Shared Neighborhood Hits	49
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.080551 (rank : 110)
Query Neighborhood Hits	108	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.055428 (rank : 145)
Query Neighborhood Hits	108	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH3G3_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.144247 (rank : 44)
Query Neighborhood Hits	108	Target Neighborhood Hits	222	Shared Neighborhood Hits	59
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SHAN1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.065383 (rank : 127)
Query Neighborhood Hits	108	Target Neighborhood Hits	1041	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.072564 (rank : 118)
Query Neighborhood Hits	108	Target Neighborhood Hits	446	Shared Neighborhood Hits	63
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHLB1_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.057756 (rank : 138)
Query Neighborhood Hits	108	Target Neighborhood Hits	96	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.057192 (rank : 140)
Query Neighborhood Hits	108	Target Neighborhood Hits	101	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SNX18_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.075310 (rank : 116)
Query Neighborhood Hits	108	Target Neighborhood Hits	207	Shared Neighborhood Hits	52
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.078595 (rank : 111)
Query Neighborhood Hits	108	Target Neighborhood Hits	198	Shared Neighborhood Hits	53
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.058786 (rank : 133)
Query Neighborhood Hits	108	Target Neighborhood Hits	148	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SRC8_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.114489 (rank : 73)
Query Neighborhood Hits	108	Target Neighborhood Hits	269	Shared Neighborhood Hits	56
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.114746 (rank : 72)
Query Neighborhood Hits	108	Target Neighborhood Hits	292	Shared Neighborhood Hits	57
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.054324 (rank : 149)
Query Neighborhood Hits	108	Target Neighborhood Hits	390	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.058103 (rank : 137)
Query Neighborhood Hits	108	Target Neighborhood Hits	331	Shared Neighborhood Hits	56
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.058457 (rank : 135)
Query Neighborhood Hits	108	Target Neighborhood Hits	324	Shared Neighborhood Hits	55
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.099389 (rank : 84)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	54
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.099389 (rank : 83)
Query Neighborhood Hits	108	Target Neighborhood Hits	232	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.120571 (rank : 67)
Query Neighborhood Hits	108	Target Neighborhood Hits	271	Shared Neighborhood Hits	63
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.110556 (rank : 76)
Query Neighborhood Hits	108	Target Neighborhood Hits	273	Shared Neighborhood Hits	63
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.106530 (rank : 80)
Query Neighborhood Hits	108	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.108664 (rank : 79)
Query Neighborhood Hits	108	Target Neighborhood Hits	285	Shared Neighborhood Hits	61
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STS2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.050510 (rank : 154)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	35
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

Hits sorted by NC score

SLY_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SLY_HUMAN
NC score	0.990636 (rank : 2)	θ value	4.24358e-175 (rank : 2)
Query Neighborhood Hits	108	Target Neighborhood Hits	81	Shared Neighborhood Hits	68
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SAMN1_MOUSE
NC score	0.929349 (rank : 3)	θ value	2.40537e-61 (rank : 4)
Query Neighborhood Hits	108	Target Neighborhood Hits	69	Shared Neighborhood Hits	49
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SAMN1_HUMAN
NC score	0.922484 (rank : 4)	θ value	2.32979e-56 (rank : 6)
Query Neighborhood Hits	108	Target Neighborhood Hits	74	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SASH1_HUMAN
NC score	0.838390 (rank : 5)	θ value	6.32992e-62 (rank : 3)
Query Neighborhood Hits	108	Target Neighborhood Hits	292	Shared Neighborhood Hits	63
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
NC score	0.833082 (rank : 6)	θ value	1.55911e-60 (rank : 5)
Query Neighborhood Hits	108	Target Neighborhood Hits	263	Shared Neighborhood Hits	62
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CD2AP_HUMAN
NC score	0.296477 (rank : 7)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	108	Target Neighborhood Hits	315	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_HUMAN
NC score	0.274926 (rank : 8)	θ value	0.000270298 (rank : 10)
Query Neighborhood Hits	108	Target Neighborhood Hits	341	Shared Neighborhood Hits	66
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.272293 (rank : 9)	θ value	0.000270298 (rank : 11)
Query Neighborhood Hits	108	Target Neighborhood Hits	332	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.262494 (rank : 10)	θ value	0.00020696 (rank : 9)
Query Neighborhood Hits	108	Target Neighborhood Hits	336	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CRK_MOUSE
NC score	0.258687 (rank : 11)	θ value	0.000461057 (rank : 12)
Query Neighborhood Hits	108	Target Neighborhood Hits	314	Shared Neighborhood Hits	66
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.249913 (rank : 12)	θ value	0.00228821 (rank : 15)
Query Neighborhood Hits	108	Target Neighborhood Hits	308	Shared Neighborhood Hits	67
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
NC score	0.246439 (rank : 13)	θ value	0.00175202 (rank : 13)
Query Neighborhood Hits	108	Target Neighborhood Hits	313	Shared Neighborhood Hits	67
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.245923 (rank : 14)	θ value	0.00175202 (rank : 14)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ARHG6_HUMAN
NC score	0.203419 (rank : 15)	θ value	0.21417 (rank : 34)
Query Neighborhood Hits	108	Target Neighborhood Hits	376	Shared Neighborhood Hits	63
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VINEX_HUMAN
NC score	0.201060 (rank : 16)	θ value	0.00869519 (rank : 20)
Query Neighborhood Hits	108	Target Neighborhood Hits	270	Shared Neighborhood Hits	61
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ARHG6_MOUSE
NC score	0.201013 (rank : 17)	θ value	0.0431538 (rank : 22)
Query Neighborhood Hits	108	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
NC score	0.197092 (rank : 18)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.195049 (rank : 19)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VINEX_MOUSE
NC score	0.194278 (rank : 20)	θ value	0.0252991 (rank : 21)
Query Neighborhood Hits	108	Target Neighborhood Hits	286	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRAP_HUMAN
NC score	0.188082 (rank : 21)	θ value	0.163984 (rank : 33)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SH3G3_MOUSE
NC score	0.183464 (rank : 22)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	108	Target Neighborhood Hits	236	Shared Neighborhood Hits	63
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_HUMAN
NC score	0.183152 (rank : 23)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.182512 (rank : 24)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	108	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP_MOUSE
NC score	0.180090 (rank : 25)	θ value	0.0563607 (rank : 25)
Query Neighborhood Hits	108	Target Neighborhood Hits	309	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.177623 (rank : 26)	θ value	0.21417 (rank : 35)
Query Neighborhood Hits	108	Target Neighborhood Hits	310	Shared Neighborhood Hits	63
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SH3G2_MOUSE
NC score	0.174163 (rank : 27)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	108	Target Neighborhood Hits	319	Shared Neighborhood Hits	63
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABI2_MOUSE
NC score	0.169097 (rank : 28)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	108	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

VAV_MOUSE
NC score	0.168195 (rank : 29)	θ value	0.125558 (rank : 32)
Query Neighborhood Hits	108	Target Neighborhood Hits	430	Shared Neighborhood Hits	63
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ABI2_HUMAN
NC score	0.166403 (rank : 30)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	108	Target Neighborhood Hits	350	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

VAV_HUMAN
NC score	0.165787 (rank : 31)	θ value	0.365318 (rank : 40)
Query Neighborhood Hits	108	Target Neighborhood Hits	452	Shared Neighborhood Hits	60
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SH3G2_HUMAN
NC score	0.160295 (rank : 32)	θ value	0.279714 (rank : 38)
Query Neighborhood Hits	108	Target Neighborhood Hits	324	Shared Neighborhood Hits	59
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

STAC_HUMAN
NC score	0.155430 (rank : 33)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	108	Target Neighborhood Hits	276	Shared Neighborhood Hits	65
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF2_HUMAN
NC score	0.152450 (rank : 34)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	108	Target Neighborhood Hits	229	Shared Neighborhood Hits	59
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

STAC_MOUSE
NC score	0.152199 (rank : 35)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	108	Target Neighborhood Hits	268	Shared Neighborhood Hits	64
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP2_MOUSE
NC score	0.151418 (rank : 36)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	108	Target Neighborhood Hits	297	Shared Neighborhood Hits	65
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ANKS1_MOUSE
NC score	0.149412 (rank : 37)	θ value	1.69304e-06 (rank : 8)
Query Neighborhood Hits	108	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

VAV3_HUMAN
NC score	0.149247 (rank : 38)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	108	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SH3G1_MOUSE
NC score	0.148532 (rank : 39)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	108	Target Neighborhood Hits	291	Shared Neighborhood Hits	60
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

NCK1_HUMAN
NC score	0.147705 (rank : 40)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	108	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

VAV3_MOUSE
NC score	0.147161 (rank : 41)	θ value	0.279714 (rank : 39)
Query Neighborhood Hits	108	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

NPHP1_MOUSE
NC score	0.146424 (rank : 42)	θ value	0.279714 (rank : 37)
Query Neighborhood Hits	108	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SH3G1_HUMAN
NC score	0.146173 (rank : 43)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G3_HUMAN
NC score	0.144247 (rank : 44)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	108	Target Neighborhood Hits	222	Shared Neighborhood Hits	59
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ANKS1_HUMAN
NC score	0.143449 (rank : 45)	θ value	1.69304e-06 (rank : 7)
Query Neighborhood Hits	108	Target Neighborhood Hits	438	Shared Neighborhood Hits	17
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

GRAP2_HUMAN
NC score	0.142746 (rank : 46)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	108	Target Neighborhood Hits	304	Shared Neighborhood Hits	65
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCF1_HUMAN
NC score	0.138688 (rank : 47)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	108	Target Neighborhood Hits	198	Shared Neighborhood Hits	56
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
NC score	0.138672 (rank : 48)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	108	Target Neighborhood Hits	198	Shared Neighborhood Hits	57
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

GRB2_HUMAN
NC score	0.138405 (rank : 49)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	108	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.138126 (rank : 50)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	108	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

VAV2_HUMAN
NC score	0.137066 (rank : 51)	θ value	0.813845 (rank : 49)
Query Neighborhood Hits	108	Target Neighborhood Hits	453	Shared Neighborhood Hits	58
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.135921 (rank : 52)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	108	Target Neighborhood Hits	456	Shared Neighborhood Hits	58
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

OSTF1_HUMAN
NC score	0.135047 (rank : 53)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	108	Target Neighborhood Hits	466	Shared Neighborhood Hits	66
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.134682 (rank : 54)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	108	Target Neighborhood Hits	467	Shared Neighborhood Hits	66
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ITSN1_HUMAN
NC score	0.132432 (rank : 55)	θ value	0.00869519 (rank : 19)
Query Neighborhood Hits	108	Target Neighborhood Hits	1757	Shared Neighborhood Hits	72
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ABI1_MOUSE
NC score	0.132111 (rank : 56)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	108	Target Neighborhood Hits	246	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_HUMAN
NC score	0.130495 (rank : 57)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	108	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI1_HUMAN
NC score	0.129627 (rank : 58)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	108	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

NCF4_MOUSE
NC score	0.125788 (rank : 59)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	108	Target Neighborhood Hits	177	Shared Neighborhood Hits	54
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NPHP1_HUMAN
NC score	0.125773 (rank : 60)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	108	Target Neighborhood Hits	288	Shared Neighborhood Hits	52
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ITSN2_HUMAN
NC score	0.124513 (rank : 61)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	108	Target Neighborhood Hits	1173	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

DNMBP_MOUSE
NC score	0.123706 (rank : 62)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	108	Target Neighborhood Hits	435	Shared Neighborhood Hits	61
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN1_MOUSE
NC score	0.122942 (rank : 63)	θ value	0.279714 (rank : 36)
Query Neighborhood Hits	108	Target Neighborhood Hits	1669	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

HCLS1_HUMAN
NC score	0.122469 (rank : 64)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	108	Target Neighborhood Hits	358	Shared Neighborhood Hits	59
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NCF4_HUMAN
NC score	0.121896 (rank : 65)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	108	Target Neighborhood Hits	161	Shared Neighborhood Hits	50
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DNMBP_HUMAN
NC score	0.121162 (rank : 66)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	108	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAM1_HUMAN
NC score	0.120571 (rank : 67)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	108	Target Neighborhood Hits	271	Shared Neighborhood Hits	63
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI3_MOUSE
NC score	0.119828 (rank : 68)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	108	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN2_MOUSE
NC score	0.118886 (rank : 69)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	108	Target Neighborhood Hits	1371	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MYO1E_HUMAN
NC score	0.117280 (rank : 70)	θ value	0.00298849 (rank : 16)
Query Neighborhood Hits	108	Target Neighborhood Hits	293	Shared Neighborhood Hits	64
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

HCLS1_MOUSE
NC score	0.117037 (rank : 71)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	108	Target Neighborhood Hits	329	Shared Neighborhood Hits	57
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_MOUSE
NC score	0.114746 (rank : 72)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	108	Target Neighborhood Hits	292	Shared Neighborhood Hits	57
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.114489 (rank : 73)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	108	Target Neighborhood Hits	269	Shared Neighborhood Hits	56
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PPIP1_HUMAN
NC score	0.112347 (rank : 74)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	108	Target Neighborhood Hits	389	Shared Neighborhood Hits	56
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PLCG1_MOUSE
NC score	0.110753 (rank : 75)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	108	Target Neighborhood Hits	314	Shared Neighborhood Hits	56
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

STAM1_MOUSE
NC score	0.110556 (rank : 76)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	108	Target Neighborhood Hits	273	Shared Neighborhood Hits	63
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PPIP1_MOUSE
NC score	0.110258 (rank : 77)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	108	Target Neighborhood Hits	377	Shared Neighborhood Hits	55
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PLCG1_HUMAN
NC score	0.108844 (rank : 78)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	108	Target Neighborhood Hits	293	Shared Neighborhood Hits	53
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

STAM2_MOUSE
NC score	0.108664 (rank : 79)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	108	Target Neighborhood Hits	285	Shared Neighborhood Hits	61
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.106530 (rank : 80)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	108	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

MYO1F_HUMAN
NC score	0.103746 (rank : 81)	θ value	0.00665767 (rank : 17)
Query Neighborhood Hits	108	Target Neighborhood Hits	275	Shared Neighborhood Hits	67
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

DBNL_HUMAN
NC score	0.100670 (rank : 82)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	108	Target Neighborhood Hits	244	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

STAC3_MOUSE
NC score	0.099389 (rank : 83)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	108	Target Neighborhood Hits	232	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.099389 (rank : 84)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	54
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DBNL_MOUSE
NC score	0.098997 (rank : 85)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	108	Target Neighborhood Hits	306	Shared Neighborhood Hits	54
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

CT032_HUMAN
NC score	0.095620 (rank : 86)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PLCG2_HUMAN
NC score	0.095478 (rank : 87)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	108	Target Neighborhood Hits	280	Shared Neighborhood Hits	55
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PACN2_MOUSE
NC score	0.095111 (rank : 88)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	108	Target Neighborhood Hits	382	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.094781 (rank : 89)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	108	Target Neighborhood Hits	339	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

LASP1_MOUSE
NC score	0.093709 (rank : 90)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	108	Target Neighborhood Hits	297	Shared Neighborhood Hits	55
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_HUMAN
NC score	0.093196 (rank : 91)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	108	Target Neighborhood Hits	293	Shared Neighborhood Hits	54
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ARHG4_HUMAN
NC score	0.092325 (rank : 92)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	108	Target Neighborhood Hits	242	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PACN1_HUMAN
NC score	0.091897 (rank : 93)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	108	Target Neighborhood Hits	320	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.090812 (rank : 94)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	108	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN3_HUMAN
NC score	0.090481 (rank : 95)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	108	Target Neighborhood Hits	385	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NOXO1_MOUSE
NC score	0.090305 (rank : 96)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	108	Target Neighborhood Hits	114	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACN3_MOUSE
NC score	0.089896 (rank : 97)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	108	Target Neighborhood Hits	380	Shared Neighborhood Hits	57
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

CSKI1_MOUSE
NC score	0.088769 (rank : 98)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	108	Target Neighborhood Hits	1031	Shared Neighborhood Hits	42
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.087936 (rank : 99)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	108	Target Neighborhood Hits	997	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NEBL_HUMAN
NC score	0.087350 (rank : 100)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	108	Target Neighborhood Hits	457	Shared Neighborhood Hits	55
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

MYO1F_MOUSE
NC score	0.086647 (rank : 101)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	108	Target Neighborhood Hits	262	Shared Neighborhood Hits	63
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ARHG4_MOUSE
NC score	0.086492 (rank : 102)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	108	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.085278 (rank : 103)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.084806 (rank : 104)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	108	Target Neighborhood Hits	234	Shared Neighborhood Hits	54
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

AHI1_HUMAN
NC score	0.084035 (rank : 105)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	108	Target Neighborhood Hits	537	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

BCAR1_MOUSE
NC score	0.083158 (rank : 106)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	108	Target Neighborhood Hits	438	Shared Neighborhood Hits	57
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

AHI1_MOUSE
NC score	0.081687 (rank : 107)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	108	Target Neighborhood Hits	496	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CASL_MOUSE
NC score	0.081425 (rank : 108)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	108	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

BCAR1_HUMAN
NC score	0.080662 (rank : 109)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	108	Target Neighborhood Hits	554	Shared Neighborhood Hits	58
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

RIMB2_MOUSE
NC score	0.080551 (rank : 110)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	108	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SNX18_MOUSE
NC score	0.078595 (rank : 111)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	108	Target Neighborhood Hits	198	Shared Neighborhood Hits	53
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

EFS_MOUSE
NC score	0.078509 (rank : 112)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	108	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RIMB2_HUMAN
NC score	0.078348 (rank : 113)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	108	Target Neighborhood Hits	263	Shared Neighborhood Hits	49
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CASL_HUMAN
NC score	0.077886 (rank : 114)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	108	Target Neighborhood Hits	259	Shared Neighborhood Hits	56
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CSKI2_MOUSE
NC score	0.077629 (rank : 115)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	108	Target Neighborhood Hits	812	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

SNX18_HUMAN
NC score	0.075310 (rank : 116)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	108	Target Neighborhood Hits	207	Shared Neighborhood Hits	52
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CSKI2_HUMAN
NC score	0.074325 (rank : 117)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	108	Target Neighborhood Hits	747	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

SHAN2_MOUSE
NC score	0.072564 (rank : 118)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	108	Target Neighborhood Hits	446	Shared Neighborhood Hits	63
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

EFS_HUMAN
NC score	0.072437 (rank : 119)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	108	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NEBU_HUMAN
NC score	0.071675 (rank : 120)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	108	Target Neighborhood Hits	420	Shared Neighborhood Hits	54
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PEX13_MOUSE
NC score	0.070849 (rank : 121)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	108	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

NOXO1_HUMAN
NC score	0.069119 (rank : 122)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	108	Target Neighborhood Hits	100	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PEX13_HUMAN
NC score	0.068915 (rank : 123)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	108	Target Neighborhood Hits	128	Shared Neighborhood Hits	39
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

DDEF1_MOUSE
NC score	0.068418 (rank : 124)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	108	Target Neighborhood Hits	592	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RHG04_HUMAN
NC score	0.067607 (rank : 125)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	108	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RUSC1_HUMAN
NC score	0.065683 (rank : 126)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	108	Target Neighborhood Hits	226	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SHAN1_HUMAN
NC score	0.065383 (rank : 127)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	108	Target Neighborhood Hits	1041	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

DDEF2_MOUSE
NC score	0.062124 (rank : 128)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	108	Target Neighborhood Hits	625	Shared Neighborhood Hits	61
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

IASPP_HUMAN
NC score	0.061160 (rank : 129)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	108	Target Neighborhood Hits	688	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DDEF2_HUMAN
NC score	0.060932 (rank : 130)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	108	Target Neighborhood Hits	599	Shared Neighborhood Hits	58
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ES8L3_MOUSE
NC score	0.060494 (rank : 131)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	108	Target Neighborhood Hits	168	Shared Neighborhood Hits	50
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

IASPP_MOUSE
NC score	0.060299 (rank : 132)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	108	Target Neighborhood Hits	1024	Shared Neighborhood Hits	64
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SNX9_HUMAN
NC score	0.058786 (rank : 133)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	108	Target Neighborhood Hits	148	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

NGEF_MOUSE
NC score	0.058517 (rank : 134)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SRGP2_MOUSE
NC score	0.058457 (rank : 135)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	108	Target Neighborhood Hits	324	Shared Neighborhood Hits	55
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ARHG5_HUMAN
NC score	0.058436 (rank : 136)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	108	Target Neighborhood Hits	172	Shared Neighborhood Hits	45
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SRGP2_HUMAN
NC score	0.058103 (rank : 137)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	108	Target Neighborhood Hits	331	Shared Neighborhood Hits	56
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SHLB1_HUMAN
NC score	0.057756 (rank : 138)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	108	Target Neighborhood Hits	96	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

ASPP1_MOUSE
NC score	0.057405 (rank : 139)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	108	Target Neighborhood Hits	1244	Shared Neighborhood Hits	63
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SHLB1_MOUSE
NC score	0.057192 (rank : 140)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	108	Target Neighborhood Hits	101	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ASPP1_HUMAN
NC score	0.056496 (rank : 141)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	108	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RHG26_HUMAN
NC score	0.055945 (rank : 142)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	108	Target Neighborhood Hits	281	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

NGEF_HUMAN
NC score	0.055724 (rank : 143)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

EPS8_HUMAN
NC score	0.055596 (rank : 144)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	108	Target Neighborhood Hits	151	Shared Neighborhood Hits	47
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

RUSC1_MOUSE
NC score	0.055428 (rank : 145)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	108	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ASPP2_HUMAN
NC score	0.054726 (rank : 146)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	108	Target Neighborhood Hits	1156	Shared Neighborhood Hits	60
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

PKHG1_HUMAN
NC score	0.054607 (rank : 147)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	108	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ANM2_HUMAN
NC score	0.054467 (rank : 148)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	108	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SRGP1_HUMAN
NC score	0.054324 (rank : 149)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	108	Target Neighborhood Hits	390	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.054110 (rank : 150)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	108	Target Neighborhood Hits	432	Shared Neighborhood Hits	55
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

TCF20_MOUSE
NC score	0.052848 (rank : 151)	θ value	0.125558 (rank : 31)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

ANM2_MOUSE
NC score	0.051550 (rank : 152)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	108	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

EPS8_MOUSE
NC score	0.051125 (rank : 153)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	108	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

STS2_HUMAN
NC score	0.050510 (rank : 154)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	35
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCF20_HUMAN
NC score	0.046508 (rank : 155)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	108	Target Neighborhood Hits	323	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

M3K11_HUMAN
NC score	0.039103 (rank : 156)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	108	Target Neighborhood Hits	1136	Shared Neighborhood Hits	63
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3KL4_HUMAN
NC score	0.035552 (rank : 157)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	108	Target Neighborhood Hits	1087	Shared Neighborhood Hits	58
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

FRDA_HUMAN
NC score	0.029966 (rank : 158)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	108	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q16595, O15545, O95656, Q15294	Gene names	FXN, FRDA, X25
Domain Architecture
Description	Frataxin, mitochondrial precursor (Friedreich ataxia protein) (Fxn) [Contains: Frataxin intermediate form].

CEND1_HUMAN
NC score	0.026789 (rank : 159)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	108	Target Neighborhood Hits	284	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

SRRM2_MOUSE
NC score	0.026026 (rank : 160)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	108	Target Neighborhood Hits	1470	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PF21A_HUMAN
NC score	0.025155 (rank : 161)	θ value	1.38821 (rank : 53)
Query Neighborhood Hits	108	Target Neighborhood Hits	303	Shared Neighborhood Hits	4
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

PF21A_MOUSE
NC score	0.024812 (rank : 162)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	108	Target Neighborhood Hits	285	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

SRRM2_HUMAN
NC score	0.024800 (rank : 163)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	108	Target Neighborhood Hits	1296	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SCNNB_HUMAN
NC score	0.022190 (rank : 164)	θ value	0.813845 (rank : 47)
Query Neighborhood Hits	108	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P51168, O60891, Q96KG2, Q9UJ32, Q9UMU5	Gene names	SCNN1B
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH) (ENaCB).

CSKP_HUMAN
NC score	0.021426 (rank : 165)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	108	Target Neighborhood Hits	1022	Shared Neighborhood Hits	49
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
NC score	0.020840 (rank : 166)	θ value	0.813845 (rank : 43)
Query Neighborhood Hits	108	Target Neighborhood Hits	1027	Shared Neighborhood Hits	52
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CABIN_HUMAN
NC score	0.020271 (rank : 167)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	108	Target Neighborhood Hits	490	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

TERF2_HUMAN
NC score	0.018984 (rank : 168)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	108	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

UN119_HUMAN
NC score	0.018753 (rank : 169)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	108	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q13432, O95126	Gene names	UNC119, RG4
Domain Architecture
Description	Unc-119 protein homolog (Retinal protein 4) (HRG4).

PAX5_HUMAN
NC score	0.017036 (rank : 170)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	108	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q02548, O75933	Gene names	PAX5
Domain Architecture
Description	Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP).

AKTS1_HUMAN
NC score	0.016365 (rank : 171)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	108	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B36, Q96BI4, Q96IK7, Q96NG2, Q9BWR5	Gene names	AKT1S1, PRAS40
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate).

TLE2_HUMAN
NC score	0.015760 (rank : 172)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	108	Target Neighborhood Hits	321	Shared Neighborhood Hits	5
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

TLE2_MOUSE
NC score	0.015150 (rank : 173)	θ value	1.38821 (rank : 54)
Query Neighborhood Hits	108	Target Neighborhood Hits	294	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

EPHA2_MOUSE
NC score	0.014303 (rank : 174)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	108	Target Neighborhood Hits	1020	Shared Neighborhood Hits	20
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

ZCHC8_MOUSE
NC score	0.012897 (rank : 175)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	108	Target Neighborhood Hits	134	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYA6, Q3TK71, Q8CCB7, Q91WQ1	Gene names	Zcchc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

EPHA2_HUMAN
NC score	0.012641 (rank : 176)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	108	Target Neighborhood Hits	1021	Shared Neighborhood Hits	21
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

N4BP3_HUMAN
NC score	0.012119 (rank : 177)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	108	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	O15049, Q7Z6I3	Gene names	N4BP3, KIAA0341
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

LAMA3_MOUSE
NC score	0.011909 (rank : 178)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	108	Target Neighborhood Hits	859	Shared Neighborhood Hits	10
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

PAX5_MOUSE
NC score	0.010107 (rank : 179)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	108	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q02650	Gene names	Pax5, Pax-5
Domain Architecture
Description	Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP).

KBTBB_HUMAN
NC score	0.010013 (rank : 180)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	108	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

RTN1_HUMAN
NC score	0.009028 (rank : 181)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	108	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

RAIN_MOUSE
NC score	0.008647 (rank : 182)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	108	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

TWST2_MOUSE
NC score	0.008243 (rank : 183)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	108	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_HUMAN
NC score	0.008227 (rank : 184)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	108	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

PJA1_HUMAN
NC score	0.007983 (rank : 185)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	108	Target Neighborhood Hits	159	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NG27, Q8NG28, Q9HAC1	Gene names	PJA1, RNF70
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-) (RING finger protein 70).

SYP2L_HUMAN
NC score	0.007253 (rank : 186)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	108	Target Neighborhood Hits	400	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

GP152_HUMAN
NC score	0.006924 (rank : 187)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	108	Target Neighborhood Hits	636	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

GOGA3_HUMAN
NC score	0.006671 (rank : 188)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	108	Target Neighborhood Hits	1317	Shared Neighborhood Hits	11
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

ADDA_HUMAN
NC score	0.006566 (rank : 189)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	3
SwissProt Accessions	P35611, Q13734, Q14729, Q16156, Q9UJB6	Gene names	ADD1, ADDA
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

SYNE2_HUMAN
NC score	0.006346 (rank : 190)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	108	Target Neighborhood Hits	1323	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

COGA1_HUMAN
NC score	0.005407 (rank : 191)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	108	Target Neighborhood Hits	345	Shared Neighborhood Hits	3
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

KCNH3_MOUSE
NC score	0.004987 (rank : 192)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	108	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

M3K12_HUMAN
NC score	0.003368 (rank : 193)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	108	Target Neighborhood Hits	940	Shared Neighborhood Hits	8
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

NMDE4_HUMAN
NC score	0.003336 (rank : 194)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	108	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

ZN192_HUMAN
NC score	0.000268 (rank : 195)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	108	Target Neighborhood Hits	789	Shared Neighborhood Hits	5
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).

ZBT40_HUMAN
NC score	-0.000325 (rank : 196)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	108	Target Neighborhood Hits	949	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.