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Network neighborhood for query Sequence : SLY_HUMAN

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SLY_HUMAN
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SLY_HUMAN
θ value	8.53067e-184 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	4.24358e-175 (rank : 2)	NC score	0.990636 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SAMN1_MOUSE
θ value	1.50663e-63 (rank : 3)	NC score	0.940263 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
θ value	5.92465e-60 (rank : 4)	NC score	0.841303 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	292	Shared Neighborhood Hits	59
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SAMN1_HUMAN
θ value	6.55044e-59 (rank : 5)	NC score	0.933333 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SASH1_MOUSE
θ value	8.55514e-59 (rank : 6)	NC score	0.836015 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	263	Shared Neighborhood Hits	57
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ANKS1_HUMAN
θ value	1.69304e-06 (rank : 7)	NC score	0.143090 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	16
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	1.69304e-06 (rank : 8)	NC score	0.148653 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

CD2AP_MOUSE
θ value	0.000270298 (rank : 9)	NC score	0.241911 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	336	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_HUMAN
θ value	0.000270298 (rank : 10)	NC score	0.256140 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	341	Shared Neighborhood Hits	60
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.000270298 (rank : 11)	NC score	0.254551 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	332	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CRK_MOUSE
θ value	0.00228821 (rank : 12)	NC score	0.235830 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
θ value	0.00509761 (rank : 13)	NC score	0.226748 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	308	Shared Neighborhood Hits	59
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
θ value	0.0113563 (rank : 14)	NC score	0.223467 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

MYO1F_HUMAN
θ value	0.0113563 (rank : 15)	NC score	0.092752 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	275	Shared Neighborhood Hits	59
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

CD2AP_HUMAN
θ value	0.0148317 (rank : 16)	NC score	0.277011 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	315	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CRKL_MOUSE
θ value	0.0252991 (rank : 17)	NC score	0.222744 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3G3_MOUSE
θ value	0.0252991 (rank : 18)	NC score	0.165948 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	236	Shared Neighborhood Hits	56
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

MYO1E_HUMAN
θ value	0.0431538 (rank : 19)	NC score	0.106323 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	293	Shared Neighborhood Hits	57
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

CSKI1_MOUSE
θ value	0.0563607 (rank : 20)	NC score	0.085503 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	1031	Shared Neighborhood Hits	37
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

GRAP_HUMAN
θ value	0.0563607 (rank : 21)	NC score	0.172767 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ARHG7_HUMAN
θ value	0.0736092 (rank : 22)	NC score	0.181158 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	347	Shared Neighborhood Hits	59
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CSKI1_HUMAN
θ value	0.0736092 (rank : 23)	NC score	0.085207 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	997	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NCK2_HUMAN
θ value	0.0736092 (rank : 24)	NC score	0.166179 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	310	Shared Neighborhood Hits	58
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SH3G2_MOUSE
θ value	0.0961366 (rank : 25)	NC score	0.155222 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	319	Shared Neighborhood Hits	56
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

VAV_MOUSE
θ value	0.0961366 (rank : 26)	NC score	0.162765 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	430	Shared Neighborhood Hits	56
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ITSN1_HUMAN
θ value	0.125558 (rank : 27)	NC score	0.116151 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	1757	Shared Neighborhood Hits	65
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VAV_HUMAN
θ value	0.125558 (rank : 28)	NC score	0.160798 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG6_HUMAN
θ value	0.163984 (rank : 29)	NC score	0.187517 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	376	Shared Neighborhood Hits	56
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.163984 (rank : 30)	NC score	0.184421 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	394	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

GRAP_MOUSE
θ value	0.163984 (rank : 31)	NC score	0.165339 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	309	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ARHG7_MOUSE
θ value	0.279714 (rank : 32)	NC score	0.178508 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV3_HUMAN
θ value	0.279714 (rank : 33)	NC score	0.145330 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	398	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	0.279714 (rank : 34)	NC score	0.143393 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	404	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SH3G2_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.141203 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

VAV2_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.133270 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.62314 (rank : 37)	NC score	0.132229 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	456	Shared Neighborhood Hits	56
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VINEX_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.165770 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	286	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

M3K9_HUMAN
θ value	0.813845 (rank : 39)	NC score	0.038887 (rank : 141)
Query Neighborhood Hits	81	Target Neighborhood Hits	1123	Shared Neighborhood Hits	57
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

VINEX_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.171112 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	270	Shared Neighborhood Hits	54
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ITSN1_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.106190 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	1669	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

M3K11_HUMAN
θ value	1.06291 (rank : 42)	NC score	0.034690 (rank : 142)
Query Neighborhood Hits	81	Target Neighborhood Hits	1136	Shared Neighborhood Hits	57
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NCK1_HUMAN
θ value	1.06291 (rank : 43)	NC score	0.135352 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	312	Shared Neighborhood Hits	53
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SRBS1_HUMAN
θ value	1.38821 (rank : 44)	NC score	0.163843 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	1.38821 (rank : 45)	NC score	0.162283 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ZN192_HUMAN
θ value	1.38821 (rank : 46)	NC score	0.000933 (rank : 162)
Query Neighborhood Hits	81	Target Neighborhood Hits	789	Shared Neighborhood Hits	6
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).

ZN518_HUMAN
θ value	1.38821 (rank : 47)	NC score	0.006777 (rank : 157)
Query Neighborhood Hits	81	Target Neighborhood Hits	780	Shared Neighborhood Hits	3
SwissProt Accessions	Q6AHZ1, O15044, Q32MP4	Gene names	ZNF518, KIAA0335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 518.

ABI2_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.133887 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	350	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	1.81305 (rank : 49)	NC score	0.136896 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ITSN2_HUMAN
θ value	1.81305 (rank : 50)	NC score	0.106821 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	1173	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	1.81305 (rank : 51)	NC score	0.101921 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	1371	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MYO1F_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.076157 (rank : 101)
Query Neighborhood Hits	81	Target Neighborhood Hits	262	Shared Neighborhood Hits	56
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

GRAP2_MOUSE
θ value	3.0926 (rank : 53)	NC score	0.136084 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	57
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

LAMA3_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.010808 (rank : 151)
Query Neighborhood Hits	81	Target Neighborhood Hits	859	Shared Neighborhood Hits	11
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

PAX5_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.013800 (rank : 148)
Query Neighborhood Hits	81	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q02548, O75933	Gene names	PAX5
Domain Architecture
Description	Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP).

STAC_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.142055 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	276	Shared Neighborhood Hits	59
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ATAD2_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.005527 (rank : 159)
Query Neighborhood Hits	81	Target Neighborhood Hits	322	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

CSKI2_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.069037 (rank : 113)
Query Neighborhood Hits	81	Target Neighborhood Hits	747	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA2_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.013344 (rank : 149)
Query Neighborhood Hits	81	Target Neighborhood Hits	1020	Shared Neighborhood Hits	15
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

GRAP2_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.127825 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	304	Shared Neighborhood Hits	57
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

MACF1_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.007274 (rank : 155)
Query Neighborhood Hits	81	Target Neighborhood Hits	1313	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

NPHP1_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.110191 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	267	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SHAN1_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.062799 (rank : 119)
Query Neighborhood Hits	81	Target Neighborhood Hits	1041	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

STAC_MOUSE
θ value	5.27518 (rank : 64)	NC score	0.139702 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	268	Shared Neighborhood Hits	59
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

FRDA_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.028824 (rank : 144)
Query Neighborhood Hits	81	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q16595, O15545, O95656, Q15294	Gene names	FXN, FRDA, X25
Domain Architecture
Description	Frataxin, mitochondrial precursor (Friedreich ataxia protein) (Fxn) [Contains: Frataxin intermediate form].

GP152_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.006630 (rank : 158)
Query Neighborhood Hits	81	Target Neighborhood Hits	636	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

OSTF1_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.117297 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	467	Shared Neighborhood Hits	58
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

TAF3_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.010455 (rank : 152)
Query Neighborhood Hits	81	Target Neighborhood Hits	568	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TERF2_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.018977 (rank : 146)
Query Neighborhood Hits	81	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

AL2S4_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.030362 (rank : 143)
Query Neighborhood Hits	81	Target Neighborhood Hits	193	Shared Neighborhood Hits	5
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

E41L1_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.003446 (rank : 161)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

EPHA2_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.011647 (rank : 150)
Query Neighborhood Hits	81	Target Neighborhood Hits	1021	Shared Neighborhood Hits	16
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

H2AW_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.004303 (rank : 160)
Query Neighborhood Hits	81	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCK0, Q3TNT4, Q925I6	Gene names	H2afy2, H2afy3
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

MACF1_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.007089 (rank : 156)
Query Neighborhood Hits	81	Target Neighborhood Hits	1341	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.008276 (rank : 153)
Query Neighborhood Hits	81	Target Neighborhood Hits	1321	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MAP4_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.007913 (rank : 154)
Query Neighborhood Hits	81	Target Neighborhood Hits	428	Shared Neighborhood Hits	4
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

NCF2_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.133720 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

OSTF1_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.116620 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	466	Shared Neighborhood Hits	58
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SCNNB_HUMAN
θ value	8.99809 (rank : 79)	NC score	0.015059 (rank : 147)
Query Neighborhood Hits	81	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P51168, O60891, Q96KG2, Q9UJ32, Q9UMU5	Gene names	SCNN1B
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH) (ENaCB).

SH3G1_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.128074 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	54
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

TCF20_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.021455 (rank : 145)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

ABI1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.099249 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	257	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.101847 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	246	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.099861 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.089722 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.070562 (rank : 110)
Query Neighborhood Hits	81	Target Neighborhood Hits	537	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.068106 (rank : 114)
Query Neighborhood Hits	81	Target Neighborhood Hits	496	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG4_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.084899 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.081061 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	185	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.050448 (rank : 139)
Query Neighborhood Hits	81	Target Neighborhood Hits	172	Shared Neighborhood Hits	42
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG9_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.078821 (rank : 93)
Query Neighborhood Hits	81	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.078433 (rank : 95)
Query Neighborhood Hits	81	Target Neighborhood Hits	234	Shared Neighborhood Hits	50
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.051683 (rank : 133)
Query Neighborhood Hits	81	Target Neighborhood Hits	956	Shared Neighborhood Hits	58
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.051854 (rank : 132)
Query Neighborhood Hits	81	Target Neighborhood Hits	1244	Shared Neighborhood Hits	60
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.071154 (rank : 109)
Query Neighborhood Hits	81	Target Neighborhood Hits	554	Shared Neighborhood Hits	54
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.073096 (rank : 105)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	53
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.067686 (rank : 115)
Query Neighborhood Hits	81	Target Neighborhood Hits	259	Shared Neighborhood Hits	51
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.070506 (rank : 111)
Query Neighborhood Hits	81	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CSKI2_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.072078 (rank : 107)
Query Neighborhood Hits	81	Target Neighborhood Hits	812	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CT032_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.083884 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.085314 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	244	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.084003 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	306	Shared Neighborhood Hits	49
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.058540 (rank : 124)
Query Neighborhood Hits	81	Target Neighborhood Hits	592	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.052883 (rank : 131)
Query Neighborhood Hits	81	Target Neighborhood Hits	599	Shared Neighborhood Hits	54
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.053322 (rank : 128)
Query Neighborhood Hits	81	Target Neighborhood Hits	625	Shared Neighborhood Hits	52
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DNMBP_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.107370 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	413	Shared Neighborhood Hits	52
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.109630 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	435	Shared Neighborhood Hits	53
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EFS_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.060835 (rank : 121)
Query Neighborhood Hits	81	Target Neighborhood Hits	348	Shared Neighborhood Hits	47
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.066612 (rank : 116)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	47
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EPS8_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.050317 (rank : 140)
Query Neighborhood Hits	81	Target Neighborhood Hits	151	Shared Neighborhood Hits	44
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L3_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.050662 (rank : 138)
Query Neighborhood Hits	81	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

GRB2_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.121465 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	310	Shared Neighborhood Hits	51
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.121344 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	312	Shared Neighborhood Hits	51
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.106749 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	358	Shared Neighborhood Hits	53
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.101410 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	329	Shared Neighborhood Hits	50
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.053591 (rank : 127)
Query Neighborhood Hits	81	Target Neighborhood Hits	688	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.053218 (rank : 129)
Query Neighborhood Hits	81	Target Neighborhood Hits	1024	Shared Neighborhood Hits	52
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.077741 (rank : 97)
Query Neighborhood Hits	81	Target Neighborhood Hits	293	Shared Neighborhood Hits	49
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.077173 (rank : 99)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	50
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCF1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.114645 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	51
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.114745 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.104514 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	161	Shared Neighborhood Hits	47
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.106610 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	177	Shared Neighborhood Hits	49
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.073883 (rank : 104)
Query Neighborhood Hits	81	Target Neighborhood Hits	457	Shared Neighborhood Hits	54
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.060701 (rank : 123)
Query Neighborhood Hits	81	Target Neighborhood Hits	420	Shared Neighborhood Hits	49
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.051267 (rank : 136)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.056881 (rank : 126)
Query Neighborhood Hits	81	Target Neighborhood Hits	100	Shared Neighborhood Hits	37
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.076175 (rank : 100)
Query Neighborhood Hits	81	Target Neighborhood Hits	114	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.089054 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PACN1_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.078447 (rank : 94)
Query Neighborhood Hits	81	Target Neighborhood Hits	320	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.077432 (rank : 98)
Query Neighborhood Hits	81	Target Neighborhood Hits	283	Shared Neighborhood Hits	50
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.081575 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.081132 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	382	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.075575 (rank : 102)
Query Neighborhood Hits	81	Target Neighborhood Hits	385	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.075484 (rank : 103)
Query Neighborhood Hits	81	Target Neighborhood Hits	380	Shared Neighborhood Hits	48
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.060739 (rank : 122)
Query Neighborhood Hits	81	Target Neighborhood Hits	128	Shared Neighborhood Hits	36
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.061351 (rank : 120)
Query Neighborhood Hits	81	Target Neighborhood Hits	126	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.053154 (rank : 130)
Query Neighborhood Hits	81	Target Neighborhood Hits	174	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG1_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.089424 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	293	Shared Neighborhood Hits	49
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.090699 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	314	Shared Neighborhood Hits	50
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.077842 (rank : 96)
Query Neighborhood Hits	81	Target Neighborhood Hits	280	Shared Neighborhood Hits	50
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.095525 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.093295 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	377	Shared Neighborhood Hits	49
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RHG04_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.057928 (rank : 125)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	51
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB2_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.069487 (rank : 112)
Query Neighborhood Hits	81	Target Neighborhood Hits	263	Shared Neighborhood Hits	46
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.072627 (rank : 106)
Query Neighborhood Hits	81	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SH3G1_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.130322 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	291	Shared Neighborhood Hits	54
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.127332 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	222	Shared Neighborhood Hits	52
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.071267 (rank : 108)
Query Neighborhood Hits	81	Target Neighborhood Hits	446	Shared Neighborhood Hits	57
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHLB1_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.051659 (rank : 134)
Query Neighborhood Hits	81	Target Neighborhood Hits	96	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.051368 (rank : 135)
Query Neighborhood Hits	81	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SNX18_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.063269 (rank : 118)
Query Neighborhood Hits	81	Target Neighborhood Hits	207	Shared Neighborhood Hits	45
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.066305 (rank : 117)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	46
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.051249 (rank : 137)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SRC8_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.098080 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	269	Shared Neighborhood Hits	50
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.097733 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.088135 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.088847 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	232	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.104271 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	271	Shared Neighborhood Hits	55
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.093591 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	273	Shared Neighborhood Hits	53
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.089654 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.092142 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	285	Shared Neighborhood Hits	53
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

Hits sorted by NC score

SLY_HUMAN
NC score	0.999962 (rank : 1)	θ value	8.53067e-184 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
NC score	0.990636 (rank : 2)	θ value	4.24358e-175 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SAMN1_MOUSE
NC score	0.940263 (rank : 3)	θ value	1.50663e-63 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SAMN1_HUMAN
NC score	0.933333 (rank : 4)	θ value	6.55044e-59 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SASH1_HUMAN
NC score	0.841303 (rank : 5)	θ value	5.92465e-60 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	292	Shared Neighborhood Hits	59
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
NC score	0.836015 (rank : 6)	θ value	8.55514e-59 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	263	Shared Neighborhood Hits	57
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CD2AP_HUMAN
NC score	0.277011 (rank : 7)	θ value	0.0148317 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	315	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_HUMAN
NC score	0.256140 (rank : 8)	θ value	0.000270298 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	341	Shared Neighborhood Hits	60
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.254551 (rank : 9)	θ value	0.000270298 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	332	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.241911 (rank : 10)	θ value	0.000270298 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	336	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CRK_MOUSE
NC score	0.235830 (rank : 11)	θ value	0.00228821 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.226748 (rank : 12)	θ value	0.00509761 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	308	Shared Neighborhood Hits	59
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
NC score	0.223467 (rank : 13)	θ value	0.0113563 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.222744 (rank : 14)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ARHG6_HUMAN
NC score	0.187517 (rank : 15)	θ value	0.163984 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	376	Shared Neighborhood Hits	56
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
NC score	0.184421 (rank : 16)	θ value	0.163984 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	394	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
NC score	0.181158 (rank : 17)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	347	Shared Neighborhood Hits	59
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.178508 (rank : 18)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP_HUMAN
NC score	0.172767 (rank : 19)	θ value	0.0563607 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

VINEX_HUMAN
NC score	0.171112 (rank : 20)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	270	Shared Neighborhood Hits	54
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCK2_HUMAN
NC score	0.166179 (rank : 21)	θ value	0.0736092 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	310	Shared Neighborhood Hits	58
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SH3G3_MOUSE
NC score	0.165948 (rank : 22)	θ value	0.0252991 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	236	Shared Neighborhood Hits	56
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VINEX_MOUSE
NC score	0.165770 (rank : 23)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	286	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRAP_MOUSE
NC score	0.165339 (rank : 24)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	309	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SRBS1_HUMAN
NC score	0.163843 (rank : 25)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VAV_MOUSE
NC score	0.162765 (rank : 26)	θ value	0.0961366 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	430	Shared Neighborhood Hits	56
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SRBS1_MOUSE
NC score	0.162283 (rank : 27)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VAV_HUMAN
NC score	0.160798 (rank : 28)	θ value	0.125558 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SH3G2_MOUSE
NC score	0.155222 (rank : 29)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	319	Shared Neighborhood Hits	56
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ANKS1_MOUSE
NC score	0.148653 (rank : 30)	θ value	1.69304e-06 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

VAV3_HUMAN
NC score	0.145330 (rank : 31)	θ value	0.279714 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	398	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.143393 (rank : 32)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	404	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ANKS1_HUMAN
NC score	0.143090 (rank : 33)	θ value	1.69304e-06 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	16
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

STAC_HUMAN
NC score	0.142055 (rank : 34)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	276	Shared Neighborhood Hits	59
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH3G2_HUMAN
NC score	0.141203 (rank : 35)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

STAC_MOUSE
NC score	0.139702 (rank : 36)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	268	Shared Neighborhood Hits	59
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI2_MOUSE
NC score	0.136896 (rank : 37)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

GRAP2_MOUSE
NC score	0.136084 (rank : 38)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	57
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCK1_HUMAN
NC score	0.135352 (rank : 39)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	312	Shared Neighborhood Hits	53
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ABI2_HUMAN
NC score	0.133887 (rank : 40)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	350	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NCF2_HUMAN
NC score	0.133720 (rank : 41)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VAV2_HUMAN
NC score	0.133270 (rank : 42)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.132229 (rank : 43)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	456	Shared Neighborhood Hits	56
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SH3G1_MOUSE
NC score	0.130322 (rank : 44)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	81	Target Neighborhood Hits	291	Shared Neighborhood Hits	54
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G1_HUMAN
NC score	0.128074 (rank : 45)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	54
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

GRAP2_HUMAN
NC score	0.127825 (rank : 46)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	304	Shared Neighborhood Hits	57
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SH3G3_HUMAN
NC score	0.127332 (rank : 47)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	81	Target Neighborhood Hits	222	Shared Neighborhood Hits	52
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

GRB2_HUMAN
NC score	0.121465 (rank : 48)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	81	Target Neighborhood Hits	310	Shared Neighborhood Hits	51
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.121344 (rank : 49)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	81	Target Neighborhood Hits	312	Shared Neighborhood Hits	51
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

OSTF1_MOUSE
NC score	0.117297 (rank : 50)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	467	Shared Neighborhood Hits	58
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OSTF1_HUMAN
NC score	0.116620 (rank : 51)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	466	Shared Neighborhood Hits	58
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ITSN1_HUMAN
NC score	0.116151 (rank : 52)	θ value	0.125558 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	1757	Shared Neighborhood Hits	65
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NCF1_MOUSE
NC score	0.114745 (rank : 53)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF1_HUMAN
NC score	0.114645 (rank : 54)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	51
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NPHP1_MOUSE
NC score	0.110191 (rank : 55)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	267	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

DNMBP_MOUSE
NC score	0.109630 (rank : 56)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	81	Target Neighborhood Hits	435	Shared Neighborhood Hits	53
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.107370 (rank : 57)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	81	Target Neighborhood Hits	413	Shared Neighborhood Hits	52
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_HUMAN
NC score	0.106821 (rank : 58)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	1173	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

HCLS1_HUMAN
NC score	0.106749 (rank : 59)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	81	Target Neighborhood Hits	358	Shared Neighborhood Hits	53
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NCF4_MOUSE
NC score	0.106610 (rank : 60)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	81	Target Neighborhood Hits	177	Shared Neighborhood Hits	49
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

MYO1E_HUMAN
NC score	0.106323 (rank : 61)	θ value	0.0431538 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	293	Shared Neighborhood Hits	57
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

ITSN1_MOUSE
NC score	0.106190 (rank : 62)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	1669	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NCF4_HUMAN
NC score	0.104514 (rank : 63)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	81	Target Neighborhood Hits	161	Shared Neighborhood Hits	47
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_HUMAN
NC score	0.104271 (rank : 64)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	81	Target Neighborhood Hits	271	Shared Neighborhood Hits	55
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ITSN2_MOUSE
NC score	0.101921 (rank : 65)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	1371	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ABI1_MOUSE
NC score	0.101847 (rank : 66)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	246	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

HCLS1_MOUSE
NC score	0.101410 (rank : 67)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	81	Target Neighborhood Hits	329	Shared Neighborhood Hits	50
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI3_HUMAN
NC score	0.099861 (rank : 68)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI1_HUMAN
NC score	0.099249 (rank : 69)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	257	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SRC8_HUMAN
NC score	0.098080 (rank : 70)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	81	Target Neighborhood Hits	269	Shared Neighborhood Hits	50
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.097733 (rank : 71)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	81	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PPIP1_HUMAN
NC score	0.095525 (rank : 72)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAM1_MOUSE
NC score	0.093591 (rank : 73)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	81	Target Neighborhood Hits	273	Shared Neighborhood Hits	53
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PPIP1_MOUSE
NC score	0.093295 (rank : 74)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	81	Target Neighborhood Hits	377	Shared Neighborhood Hits	49
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

MYO1F_HUMAN
NC score	0.092752 (rank : 75)	θ value	0.0113563 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	275	Shared Neighborhood Hits	59
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

STAM2_MOUSE
NC score	0.092142 (rank : 76)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	81	Target Neighborhood Hits	285	Shared Neighborhood Hits	53
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PLCG1_MOUSE
NC score	0.090699 (rank : 77)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	81	Target Neighborhood Hits	314	Shared Neighborhood Hits	50
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ABI3_MOUSE
NC score	0.089722 (rank : 78)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAM2_HUMAN
NC score	0.089654 (rank : 79)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	81	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

PLCG1_HUMAN
NC score	0.089424 (rank : 80)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	81	Target Neighborhood Hits	293	Shared Neighborhood Hits	49
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NPHP1_HUMAN
NC score	0.089054 (rank : 81)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	81	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

STAC3_MOUSE
NC score	0.088847 (rank : 82)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	81	Target Neighborhood Hits	232	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.088135 (rank : 83)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CSKI1_MOUSE
NC score	0.085503 (rank : 84)	θ value	0.0563607 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	1031	Shared Neighborhood Hits	37
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DBNL_HUMAN
NC score	0.085314 (rank : 85)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	81	Target Neighborhood Hits	244	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

CSKI1_HUMAN
NC score	0.085207 (rank : 86)	θ value	0.0736092 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	997	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ARHG4_HUMAN
NC score	0.084899 (rank : 87)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

DBNL_MOUSE
NC score	0.084003 (rank : 88)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	81	Target Neighborhood Hits	306	Shared Neighborhood Hits	49
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

CT032_HUMAN
NC score	0.083884 (rank : 89)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	81	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PACN2_HUMAN
NC score	0.081575 (rank : 90)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	81	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.081132 (rank : 91)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	81	Target Neighborhood Hits	382	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ARHG4_MOUSE
NC score	0.081061 (rank : 92)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	185	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.078821 (rank : 93)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

PACN1_HUMAN
NC score	0.078447 (rank : 94)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	81	Target Neighborhood Hits	320	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ARHG9_MOUSE
NC score	0.078433 (rank : 95)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	234	Shared Neighborhood Hits	50
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PLCG2_HUMAN
NC score	0.077842 (rank : 96)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	81	Target Neighborhood Hits	280	Shared Neighborhood Hits	50
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

LASP1_HUMAN
NC score	0.077741 (rank : 97)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	81	Target Neighborhood Hits	293	Shared Neighborhood Hits	49
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PACN1_MOUSE
NC score	0.077432 (rank : 98)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	81	Target Neighborhood Hits	283	Shared Neighborhood Hits	50
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

LASP1_MOUSE
NC score	0.077173 (rank : 99)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	50
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NOXO1_MOUSE
NC score	0.076175 (rank : 100)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	81	Target Neighborhood Hits	114	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

MYO1F_MOUSE
NC score	0.076157 (rank : 101)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	262	Shared Neighborhood Hits	56
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PACN3_HUMAN
NC score	0.075575 (rank : 102)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	81	Target Neighborhood Hits	385	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
NC score	0.075484 (rank : 103)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	81	Target Neighborhood Hits	380	Shared Neighborhood Hits	48
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NEBL_HUMAN
NC score	0.073883 (rank : 104)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	81	Target Neighborhood Hits	457	Shared Neighborhood Hits	54
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

BCAR1_MOUSE
NC score	0.073096 (rank : 105)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	53
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

RIMB2_MOUSE
NC score	0.072627 (rank : 106)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	81	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CSKI2_MOUSE
NC score	0.072078 (rank : 107)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	81	Target Neighborhood Hits	812	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

SHAN2_MOUSE
NC score	0.071267 (rank : 108)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	81	Target Neighborhood Hits	446	Shared Neighborhood Hits	57
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

BCAR1_HUMAN
NC score	0.071154 (rank : 109)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	81	Target Neighborhood Hits	554	Shared Neighborhood Hits	54
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

AHI1_HUMAN
NC score	0.070562 (rank : 110)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	537	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CASL_MOUSE
NC score	0.070506 (rank : 111)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	81	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

RIMB2_HUMAN
NC score	0.069487 (rank : 112)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	81	Target Neighborhood Hits	263	Shared Neighborhood Hits	46
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CSKI2_HUMAN
NC score	0.069037 (rank : 113)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	747	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

AHI1_MOUSE
NC score	0.068106 (rank : 114)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	496	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CASL_HUMAN
NC score	0.067686 (rank : 115)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	81	Target Neighborhood Hits	259	Shared Neighborhood Hits	51
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

EFS_MOUSE
NC score	0.066612 (rank : 116)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	47
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SNX18_MOUSE
NC score	0.066305 (rank : 117)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	46
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.063269 (rank : 118)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	81	Target Neighborhood Hits	207	Shared Neighborhood Hits	45
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SHAN1_HUMAN
NC score	0.062799 (rank : 119)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	1041	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PEX13_MOUSE
NC score	0.061351 (rank : 120)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	81	Target Neighborhood Hits	126	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

EFS_HUMAN
NC score	0.060835 (rank : 121)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	81	Target Neighborhood Hits	348	Shared Neighborhood Hits	47
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

PEX13_HUMAN
NC score	0.060739 (rank : 122)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	81	Target Neighborhood Hits	128	Shared Neighborhood Hits	36
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

NEBU_HUMAN
NC score	0.060701 (rank : 123)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	81	Target Neighborhood Hits	420	Shared Neighborhood Hits	49
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

DDEF1_MOUSE
NC score	0.058540 (rank : 124)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	81	Target Neighborhood Hits	592	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RHG04_HUMAN
NC score	0.057928 (rank : 125)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	81	Target Neighborhood Hits	307	Shared Neighborhood Hits	51
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NOXO1_HUMAN
NC score	0.056881 (rank : 126)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	81	Target Neighborhood Hits	100	Shared Neighborhood Hits	37
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

IASPP_HUMAN
NC score	0.053591 (rank : 127)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	81	Target Neighborhood Hits	688	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DDEF2_MOUSE
NC score	0.053322 (rank : 128)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	81	Target Neighborhood Hits	625	Shared Neighborhood Hits	52
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

IASPP_MOUSE
NC score	0.053218 (rank : 129)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	81	Target Neighborhood Hits	1024	Shared Neighborhood Hits	52
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PKHG1_HUMAN
NC score	0.053154 (rank : 130)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	81	Target Neighborhood Hits	174	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

DDEF2_HUMAN
NC score	0.052883 (rank : 131)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	81	Target Neighborhood Hits	599	Shared Neighborhood Hits	54
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ASPP1_MOUSE
NC score	0.051854 (rank : 132)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	81	Target Neighborhood Hits	1244	Shared Neighborhood Hits	60
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
NC score	0.051683 (rank : 133)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	81	Target Neighborhood Hits	956	Shared Neighborhood Hits	58
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SHLB1_HUMAN
NC score	0.051659 (rank : 134)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	81	Target Neighborhood Hits	96	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
NC score	0.051368 (rank : 135)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	81	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

NGEF_MOUSE
NC score	0.051267 (rank : 136)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SNX9_HUMAN
NC score	0.051249 (rank : 137)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

ES8L3_MOUSE
NC score	0.050662 (rank : 138)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	81	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ARHG5_HUMAN
NC score	0.050448 (rank : 139)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	172	Shared Neighborhood Hits	42
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

EPS8_HUMAN
NC score	0.050317 (rank : 140)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	81	Target Neighborhood Hits	151	Shared Neighborhood Hits	44
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

M3K9_HUMAN
NC score	0.038887 (rank : 141)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	1123	Shared Neighborhood Hits	57
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K11_HUMAN
NC score	0.034690 (rank : 142)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	1136	Shared Neighborhood Hits	57
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

AL2S4_MOUSE
NC score	0.030362 (rank : 143)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	193	Shared Neighborhood Hits	5
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

FRDA_HUMAN
NC score	0.028824 (rank : 144)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q16595, O15545, O95656, Q15294	Gene names	FXN, FRDA, X25
Domain Architecture
Description	Frataxin, mitochondrial precursor (Friedreich ataxia protein) (Fxn) [Contains: Frataxin intermediate form].

TCF20_MOUSE
NC score	0.021455 (rank : 145)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

TERF2_HUMAN
NC score	0.018977 (rank : 146)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

SCNNB_HUMAN
NC score	0.015059 (rank : 147)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P51168, O60891, Q96KG2, Q9UJ32, Q9UMU5	Gene names	SCNN1B
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH) (ENaCB).

PAX5_HUMAN
NC score	0.013800 (rank : 148)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q02548, O75933	Gene names	PAX5
Domain Architecture
Description	Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP).

EPHA2_MOUSE
NC score	0.013344 (rank : 149)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	1020	Shared Neighborhood Hits	15
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA2_HUMAN
NC score	0.011647 (rank : 150)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	1021	Shared Neighborhood Hits	16
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

LAMA3_MOUSE
NC score	0.010808 (rank : 151)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	859	Shared Neighborhood Hits	11
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

TAF3_HUMAN
NC score	0.010455 (rank : 152)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	568	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

MACF4_HUMAN
NC score	0.008276 (rank : 153)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	1321	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MAP4_HUMAN
NC score	0.007913 (rank : 154)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	428	Shared Neighborhood Hits	4
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MACF1_MOUSE
NC score	0.007274 (rank : 155)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	1313	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACF1_HUMAN
NC score	0.007089 (rank : 156)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	1341	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

ZN518_HUMAN
NC score	0.006777 (rank : 157)	θ value	1.38821 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	780	Shared Neighborhood Hits	3
SwissProt Accessions	Q6AHZ1, O15044, Q32MP4	Gene names	ZNF518, KIAA0335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 518.

GP152_HUMAN
NC score	0.006630 (rank : 158)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	636	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

ATAD2_HUMAN
NC score	0.005527 (rank : 159)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	322	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

H2AW_MOUSE
NC score	0.004303 (rank : 160)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCK0, Q3TNT4, Q925I6	Gene names	H2afy2, H2afy3
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

E41L1_HUMAN
NC score	0.003446 (rank : 161)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

ZN192_HUMAN
NC score	0.000933 (rank : 162)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	789	Shared Neighborhood Hits	6
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).