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Network neighborhood for query Sequence : SNX18_MOUSE

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SNX18_MOUSE
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SNX18_HUMAN
θ value	0 (rank : 1)	NC score	0.993271 (rank : 2)
Query Neighborhood Hits	198	Target Neighborhood Hits	207	Shared Neighborhood Hits	185
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	198	Target Neighborhood Hits	198	Shared Neighborhood Hits	198
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_MOUSE
θ value	1.03855e-80 (rank : 3)	NC score	0.849666 (rank : 4)
Query Neighborhood Hits	198	Target Neighborhood Hits	141	Shared Neighborhood Hits	115
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SNX9_HUMAN
θ value	1.14825e-79 (rank : 4)	NC score	0.857767 (rank : 3)
Query Neighborhood Hits	198	Target Neighborhood Hits	148	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX7_HUMAN
θ value	3.89403e-11 (rank : 5)	NC score	0.480893 (rank : 5)
Query Neighborhood Hits	198	Target Neighborhood Hits	79	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UNH6, Q86U82, Q8WVD4, Q96FW9, Q9Y3Z7	Gene names	SNX7
Domain Architecture
Description	Sorting nexin-7.

SNX7_MOUSE
θ value	5.08577e-11 (rank : 6)	NC score	0.474912 (rank : 6)
Query Neighborhood Hits	198	Target Neighborhood Hits	89	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CY18	Gene names	Snx7
Domain Architecture
Description	Sorting nexin-7.

SNX8_HUMAN
θ value	1.63604e-09 (rank : 7)	NC score	0.470445 (rank : 8)
Query Neighborhood Hits	198	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

SNX8_MOUSE
θ value	1.17247e-07 (rank : 8)	NC score	0.446482 (rank : 13)
Query Neighborhood Hits	198	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFD4, Q8BLI6, Q8BUQ7	Gene names	Snx8
Domain Architecture	No domain graphic available
Description	Sorting nexin-8.

SNX4_HUMAN
θ value	1.99992e-07 (rank : 9)	NC score	0.417154 (rank : 25)
Query Neighborhood Hits	198	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	O95219	Gene names	SNX4
Domain Architecture
Description	Sorting nexin-4.

SH3G3_MOUSE
θ value	5.81887e-07 (rank : 10)	NC score	0.472075 (rank : 7)
Query Neighborhood Hits	198	Target Neighborhood Hits	236	Shared Neighborhood Hits	132
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SNX4_MOUSE
θ value	5.81887e-07 (rank : 11)	NC score	0.415955 (rank : 26)
Query Neighborhood Hits	198	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q91YJ2	Gene names	Snx4
Domain Architecture	No domain graphic available
Description	Sorting nexin-4.

PACN3_HUMAN
θ value	9.92553e-07 (rank : 12)	NC score	0.426563 (rank : 23)
Query Neighborhood Hits	198	Target Neighborhood Hits	385	Shared Neighborhood Hits	126
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	9.92553e-07 (rank : 13)	NC score	0.428452 (rank : 22)
Query Neighborhood Hits	198	Target Neighborhood Hits	380	Shared Neighborhood Hits	127
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SH3G1_MOUSE
θ value	9.92553e-07 (rank : 14)	NC score	0.448196 (rank : 12)
Query Neighborhood Hits	198	Target Neighborhood Hits	291	Shared Neighborhood Hits	127
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
θ value	2.88788e-06 (rank : 15)	NC score	0.464668 (rank : 9)
Query Neighborhood Hits	198	Target Neighborhood Hits	222	Shared Neighborhood Hits	127
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SNX12_MOUSE
θ value	2.88788e-06 (rank : 16)	NC score	0.428833 (rank : 21)
Query Neighborhood Hits	198	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	O70493, Q9D0N3	Gene names	Snx12
Domain Architecture
Description	Sorting nexin-12 (SDP8 protein).

SH3G2_HUMAN
θ value	3.77169e-06 (rank : 17)	NC score	0.456032 (rank : 10)
Query Neighborhood Hits	198	Target Neighborhood Hits	324	Shared Neighborhood Hits	129
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PACN1_HUMAN
θ value	4.92598e-06 (rank : 18)	NC score	0.436486 (rank : 19)
Query Neighborhood Hits	198	Target Neighborhood Hits	320	Shared Neighborhood Hits	131
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	4.92598e-06 (rank : 19)	NC score	0.439152 (rank : 16)
Query Neighborhood Hits	198	Target Neighborhood Hits	283	Shared Neighborhood Hits	131
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	4.92598e-06 (rank : 20)	NC score	0.439233 (rank : 15)
Query Neighborhood Hits	198	Target Neighborhood Hits	339	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G1_HUMAN
θ value	4.92598e-06 (rank : 21)	NC score	0.445256 (rank : 14)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	128
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

PACN2_MOUSE
θ value	6.43352e-06 (rank : 22)	NC score	0.436047 (rank : 20)
Query Neighborhood Hits	198	Target Neighborhood Hits	382	Shared Neighborhood Hits	133
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SNX11_HUMAN
θ value	8.40245e-06 (rank : 23)	NC score	0.405846 (rank : 28)
Query Neighborhood Hits	198	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5W9, Q9H885	Gene names	SNX11
Domain Architecture
Description	Sorting nexin-11.

SNX1_HUMAN
θ value	8.40245e-06 (rank : 24)	NC score	0.353806 (rank : 53)
Query Neighborhood Hits	198	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

SH3G2_MOUSE
θ value	1.09739e-05 (rank : 25)	NC score	0.453148 (rank : 11)
Query Neighborhood Hits	198	Target Neighborhood Hits	319	Shared Neighborhood Hits	131
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SNX1_MOUSE
θ value	1.87187e-05 (rank : 26)	NC score	0.351114 (rank : 54)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

SNX11_MOUSE
θ value	2.44474e-05 (rank : 27)	NC score	0.397618 (rank : 33)
Query Neighborhood Hits	198	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	Q91WL6, Q3V3A6	Gene names	Snx11
Domain Architecture	No domain graphic available
Description	Sorting nexin-11.

SNX3_MOUSE
θ value	2.44474e-05 (rank : 28)	NC score	0.405028 (rank : 29)
Query Neighborhood Hits	198	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	O70492	Gene names	Snx3
Domain Architecture
Description	Sorting nexin-3 (SDP3 protein).

SNX12_HUMAN
θ value	4.1701e-05 (rank : 29)	NC score	0.407792 (rank : 27)
Query Neighborhood Hits	198	Target Neighborhood Hits	46	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UMY4, Q8WUG9	Gene names	SNX12
Domain Architecture
Description	Sorting nexin-12.

SGK3_HUMAN
θ value	5.44631e-05 (rank : 30)	NC score	0.049439 (rank : 268)
Query Neighborhood Hits	198	Target Neighborhood Hits	877	Shared Neighborhood Hits	49
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SNX2_MOUSE
θ value	5.44631e-05 (rank : 31)	NC score	0.366915 (rank : 46)
Query Neighborhood Hits	198	Target Neighborhood Hits	156	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CWK8, Q3UKW3, Q9CQV0	Gene names	Snx2
Domain Architecture
Description	Sorting nexin-2.

SNX2_HUMAN
θ value	7.1131e-05 (rank : 32)	NC score	0.367952 (rank : 44)
Query Neighborhood Hits	198	Target Neighborhood Hits	151	Shared Neighborhood Hits	40
SwissProt Accessions	O60749, O43650, P82862, Q53XK8, Q597H6, Q9BTS8	Gene names	SNX2, TRG9
Domain Architecture
Description	Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9).

SNX3_HUMAN
θ value	9.29e-05 (rank : 33)	NC score	0.398758 (rank : 32)
Query Neighborhood Hits	198	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	O60493, O60718, Q5JXJ7, Q5JXJ8, Q96AP9, Q9C0J5, Q9NU45	Gene names	SNX3
Domain Architecture
Description	Sorting nexin-3 (Protein SDP3).

VINEX_MOUSE
θ value	9.29e-05 (rank : 34)	NC score	0.438752 (rank : 17)
Query Neighborhood Hits	198	Target Neighborhood Hits	286	Shared Neighborhood Hits	138
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

CRK_MOUSE
θ value	0.000121331 (rank : 35)	NC score	0.327305 (rank : 63)
Query Neighborhood Hits	198	Target Neighborhood Hits	314	Shared Neighborhood Hits	129
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SGK3_MOUSE
θ value	0.000158464 (rank : 36)	NC score	0.048732 (rank : 269)
Query Neighborhood Hits	198	Target Neighborhood Hits	882	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

CD2AP_MOUSE
θ value	0.00020696 (rank : 37)	NC score	0.403839 (rank : 30)
Query Neighborhood Hits	198	Target Neighborhood Hits	336	Shared Neighborhood Hits	131
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

P3C2B_HUMAN
θ value	0.00020696 (rank : 38)	NC score	0.066900 (rank : 232)
Query Neighborhood Hits	198	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

VINEX_HUMAN
θ value	0.00020696 (rank : 39)	NC score	0.438354 (rank : 18)
Query Neighborhood Hits	198	Target Neighborhood Hits	270	Shared Neighborhood Hits	136
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ITSN1_HUMAN
θ value	0.000461057 (rank : 40)	NC score	0.232296 (rank : 115)
Query Neighborhood Hits	198	Target Neighborhood Hits	1757	Shared Neighborhood Hits	144
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PXK_HUMAN
θ value	0.000461057 (rank : 41)	NC score	0.276081 (rank : 86)
Query Neighborhood Hits	198	Target Neighborhood Hits	216	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

DDEF1_MOUSE
θ value	0.000602161 (rank : 42)	NC score	0.219037 (rank : 123)
Query Neighborhood Hits	198	Target Neighborhood Hits	592	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

EFS_MOUSE
θ value	0.000602161 (rank : 43)	NC score	0.321682 (rank : 64)
Query Neighborhood Hits	198	Target Neighborhood Hits	389	Shared Neighborhood Hits	121
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ITSN1_MOUSE
θ value	0.000786445 (rank : 44)	NC score	0.237746 (rank : 111)
Query Neighborhood Hits	198	Target Neighborhood Hits	1669	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NCF4_MOUSE
θ value	0.000786445 (rank : 45)	NC score	0.425867 (rank : 24)
Query Neighborhood Hits	198	Target Neighborhood Hits	177	Shared Neighborhood Hits	130
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PXK_MOUSE
θ value	0.000786445 (rank : 46)	NC score	0.270466 (rank : 92)
Query Neighborhood Hits	198	Target Neighborhood Hits	320	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

DBNL_HUMAN
θ value	0.00102713 (rank : 47)	NC score	0.374669 (rank : 39)
Query Neighborhood Hits	198	Target Neighborhood Hits	244	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.00102713 (rank : 48)	NC score	0.369931 (rank : 43)
Query Neighborhood Hits	198	Target Neighborhood Hits	306	Shared Neighborhood Hits	120
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF2_HUMAN
θ value	0.00102713 (rank : 49)	NC score	0.199929 (rank : 136)
Query Neighborhood Hits	198	Target Neighborhood Hits	599	Shared Neighborhood Hits	114
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

STAM2_MOUSE
θ value	0.00102713 (rank : 50)	NC score	0.363911 (rank : 50)
Query Neighborhood Hits	198	Target Neighborhood Hits	285	Shared Neighborhood Hits	129
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

DDEF2_MOUSE
θ value	0.00134147 (rank : 51)	NC score	0.197678 (rank : 137)
Query Neighborhood Hits	198	Target Neighborhood Hits	625	Shared Neighborhood Hits	111
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CD2AP_HUMAN
θ value	0.00175202 (rank : 52)	NC score	0.394282 (rank : 34)
Query Neighborhood Hits	198	Target Neighborhood Hits	315	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

EPS8_MOUSE
θ value	0.00228821 (rank : 53)	NC score	0.217558 (rank : 126)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

MYO1F_HUMAN
θ value	0.00228821 (rank : 54)	NC score	0.170549 (rank : 147)
Query Neighborhood Hits	198	Target Neighborhood Hits	275	Shared Neighborhood Hits	129
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NCF4_HUMAN
θ value	0.00228821 (rank : 55)	NC score	0.403537 (rank : 31)
Query Neighborhood Hits	198	Target Neighborhood Hits	161	Shared Neighborhood Hits	122
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

EPS8_HUMAN
θ value	0.00298849 (rank : 56)	NC score	0.216596 (rank : 127)
Query Neighborhood Hits	198	Target Neighborhood Hits	151	Shared Neighborhood Hits	85
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

MYO1F_MOUSE
θ value	0.00298849 (rank : 57)	NC score	0.169522 (rank : 148)
Query Neighborhood Hits	198	Target Neighborhood Hits	262	Shared Neighborhood Hits	129
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SNX16_HUMAN
θ value	0.00298849 (rank : 58)	NC score	0.275920 (rank : 87)
Query Neighborhood Hits	198	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	P57768, Q8N4U3	Gene names	SNX16
Domain Architecture
Description	Sorting nexin-16.

CIP4_HUMAN
θ value	0.00390308 (rank : 59)	NC score	0.201569 (rank : 134)
Query Neighborhood Hits	198	Target Neighborhood Hits	374	Shared Neighborhood Hits	57
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRKL_HUMAN
θ value	0.00390308 (rank : 60)	NC score	0.330657 (rank : 62)
Query Neighborhood Hits	198	Target Neighborhood Hits	313	Shared Neighborhood Hits	132
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

LASP1_HUMAN
θ value	0.00390308 (rank : 61)	NC score	0.338446 (rank : 60)
Query Neighborhood Hits	198	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00390308 (rank : 62)	NC score	0.336379 (rank : 61)
Query Neighborhood Hits	198	Target Neighborhood Hits	297	Shared Neighborhood Hits	120
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

VAV_HUMAN
θ value	0.00390308 (rank : 63)	NC score	0.271831 (rank : 90)
Query Neighborhood Hits	198	Target Neighborhood Hits	452	Shared Neighborhood Hits	133
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ABI1_MOUSE
θ value	0.00509761 (rank : 64)	NC score	0.357471 (rank : 52)
Query Neighborhood Hits	198	Target Neighborhood Hits	246	Shared Neighborhood Hits	116
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	0.00509761 (rank : 65)	NC score	0.360600 (rank : 51)
Query Neighborhood Hits	198	Target Neighborhood Hits	350	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.00509761 (rank : 66)	NC score	0.364883 (rank : 49)
Query Neighborhood Hits	198	Target Neighborhood Hits	266	Shared Neighborhood Hits	119
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ARHG5_HUMAN
θ value	0.00509761 (rank : 67)	NC score	0.166961 (rank : 150)
Query Neighborhood Hits	198	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

HCLS1_MOUSE
θ value	0.00509761 (rank : 68)	NC score	0.370693 (rank : 41)
Query Neighborhood Hits	198	Target Neighborhood Hits	329	Shared Neighborhood Hits	120
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PPIP1_HUMAN
θ value	0.00509761 (rank : 69)	NC score	0.366125 (rank : 47)
Query Neighborhood Hits	198	Target Neighborhood Hits	389	Shared Neighborhood Hits	139
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAM2_HUMAN
θ value	0.00509761 (rank : 70)	NC score	0.350936 (rank : 55)
Query Neighborhood Hits	198	Target Neighborhood Hits	288	Shared Neighborhood Hits	131
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ITSN2_HUMAN
θ value	0.00665767 (rank : 71)	NC score	0.237051 (rank : 113)
Query Neighborhood Hits	198	Target Neighborhood Hits	1173	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SRBS1_HUMAN
θ value	0.00665767 (rank : 72)	NC score	0.386552 (rank : 35)
Query Neighborhood Hits	198	Target Neighborhood Hits	396	Shared Neighborhood Hits	133
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP_MOUSE
θ value	0.00869519 (rank : 73)	NC score	0.292401 (rank : 80)
Query Neighborhood Hits	198	Target Neighborhood Hits	309	Shared Neighborhood Hits	136
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

HCLS1_HUMAN
θ value	0.00869519 (rank : 74)	NC score	0.370061 (rank : 42)
Query Neighborhood Hits	198	Target Neighborhood Hits	358	Shared Neighborhood Hits	119
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SPTA2_HUMAN
θ value	0.00869519 (rank : 75)	NC score	0.147585 (rank : 159)
Query Neighborhood Hits	198	Target Neighborhood Hits	888	Shared Neighborhood Hits	127
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_MOUSE
θ value	0.00869519 (rank : 76)	NC score	0.378016 (rank : 38)
Query Neighborhood Hits	198	Target Neighborhood Hits	409	Shared Neighborhood Hits	134
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VAV_MOUSE
θ value	0.00869519 (rank : 77)	NC score	0.271307 (rank : 91)
Query Neighborhood Hits	198	Target Neighborhood Hits	430	Shared Neighborhood Hits	135
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SNX16_MOUSE
θ value	0.0113563 (rank : 78)	NC score	0.269298 (rank : 94)
Query Neighborhood Hits	198	Target Neighborhood Hits	82	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

SPTA1_HUMAN
θ value	0.0113563 (rank : 79)	NC score	0.146557 (rank : 161)
Query Neighborhood Hits	198	Target Neighborhood Hits	748	Shared Neighborhood Hits	121
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ABI1_HUMAN
θ value	0.0148317 (rank : 80)	NC score	0.342196 (rank : 58)
Query Neighborhood Hits	198	Target Neighborhood Hits	257	Shared Neighborhood Hits	115
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

P85A_MOUSE
θ value	0.0148317 (rank : 81)	NC score	0.137543 (rank : 165)
Query Neighborhood Hits	198	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX13_HUMAN
θ value	0.0148317 (rank : 82)	NC score	0.169006 (rank : 149)
Query Neighborhood Hits	198	Target Neighborhood Hits	84	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

ARHG7_HUMAN
θ value	0.0193708 (rank : 83)	NC score	0.291235 (rank : 82)
Query Neighborhood Hits	198	Target Neighborhood Hits	347	Shared Neighborhood Hits	127
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DNMBP_HUMAN
θ value	0.0193708 (rank : 84)	NC score	0.303861 (rank : 73)
Query Neighborhood Hits	198	Target Neighborhood Hits	413	Shared Neighborhood Hits	138
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PEX13_HUMAN
θ value	0.0193708 (rank : 85)	NC score	0.314549 (rank : 66)
Query Neighborhood Hits	198	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SNX27_HUMAN
θ value	0.0193708 (rank : 86)	NC score	0.230761 (rank : 116)
Query Neighborhood Hits	198	Target Neighborhood Hits	54	Shared Neighborhood Hits	30
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

SPTA1_MOUSE
θ value	0.0193708 (rank : 87)	NC score	0.152905 (rank : 157)
Query Neighborhood Hits	198	Target Neighborhood Hits	675	Shared Neighborhood Hits	122
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRC8_MOUSE
θ value	0.0193708 (rank : 88)	NC score	0.367315 (rank : 45)
Query Neighborhood Hits	198	Target Neighborhood Hits	292	Shared Neighborhood Hits	126
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ARHG7_MOUSE
θ value	0.0252991 (rank : 89)	NC score	0.298448 (rank : 76)
Query Neighborhood Hits	198	Target Neighborhood Hits	396	Shared Neighborhood Hits	128
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CRKL_MOUSE
θ value	0.0252991 (rank : 90)	NC score	0.319498 (rank : 65)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PEX13_MOUSE
θ value	0.0252991 (rank : 91)	NC score	0.304732 (rank : 71)
Query Neighborhood Hits	198	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

GRAP_HUMAN
θ value	0.0330416 (rank : 92)	NC score	0.280440 (rank : 84)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SNX10_HUMAN
θ value	0.0330416 (rank : 93)	NC score	0.310730 (rank : 69)
Query Neighborhood Hits	198	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5X0	Gene names	SNX10
Domain Architecture
Description	Sorting nexin-10.

SNX10_MOUSE
θ value	0.0330416 (rank : 94)	NC score	0.306373 (rank : 70)
Query Neighborhood Hits	198	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CWT3, Q8C1E0	Gene names	Snx10
Domain Architecture	No domain graphic available
Description	Sorting nexin-10.

SNX13_MOUSE
θ value	0.0330416 (rank : 95)	NC score	0.165028 (rank : 153)
Query Neighborhood Hits	198	Target Neighborhood Hits	86	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

STAM1_HUMAN
θ value	0.0330416 (rank : 96)	NC score	0.348278 (rank : 57)
Query Neighborhood Hits	198	Target Neighborhood Hits	271	Shared Neighborhood Hits	132
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP2_MOUSE
θ value	0.0431538 (rank : 97)	NC score	0.298706 (rank : 75)
Query Neighborhood Hits	198	Target Neighborhood Hits	297	Shared Neighborhood Hits	134
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

P85A_HUMAN
θ value	0.0431538 (rank : 98)	NC score	0.131435 (rank : 172)
Query Neighborhood Hits	198	Target Neighborhood Hits	479	Shared Neighborhood Hits	77
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRC8_HUMAN
θ value	0.0431538 (rank : 99)	NC score	0.365522 (rank : 48)
Query Neighborhood Hits	198	Target Neighborhood Hits	269	Shared Neighborhood Hits	127
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM1_MOUSE
θ value	0.0431538 (rank : 100)	NC score	0.348324 (rank : 56)
Query Neighborhood Hits	198	Target Neighborhood Hits	273	Shared Neighborhood Hits	133
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

DNMBP_MOUSE
θ value	0.0563607 (rank : 101)	NC score	0.300204 (rank : 74)
Query Neighborhood Hits	198	Target Neighborhood Hits	435	Shared Neighborhood Hits	138
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NEBL_HUMAN
θ value	0.0563607 (rank : 102)	NC score	0.291661 (rank : 81)
Query Neighborhood Hits	198	Target Neighborhood Hits	457	Shared Neighborhood Hits	124
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	0.0563607 (rank : 103)	NC score	0.256999 (rank : 98)
Query Neighborhood Hits	198	Target Neighborhood Hits	420	Shared Neighborhood Hits	118
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PPIP1_MOUSE
θ value	0.0563607 (rank : 104)	NC score	0.370800 (rank : 40)
Query Neighborhood Hits	198	Target Neighborhood Hits	377	Shared Neighborhood Hits	140
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SNX15_HUMAN
θ value	0.0563607 (rank : 105)	NC score	0.146694 (rank : 160)
Query Neighborhood Hits	198	Target Neighborhood Hits	50	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NRS6, Q9NRS5	Gene names	SNX15
Domain Architecture
Description	Sorting nexin-15.

SNX15_MOUSE
θ value	0.0563607 (rank : 106)	NC score	0.144712 (rank : 163)
Query Neighborhood Hits	198	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WE1	Gene names	Snx15
Domain Architecture	No domain graphic available
Description	Sorting nexin-15.

ABI3_HUMAN
θ value	0.0736092 (rank : 107)	NC score	0.340855 (rank : 59)
Query Neighborhood Hits	198	Target Neighborhood Hits	227	Shared Neighborhood Hits	104
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BCAR1_HUMAN
θ value	0.0736092 (rank : 108)	NC score	0.250542 (rank : 103)
Query Neighborhood Hits	198	Target Neighborhood Hits	554	Shared Neighborhood Hits	123
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EFS_HUMAN
θ value	0.0736092 (rank : 109)	NC score	0.295134 (rank : 79)
Query Neighborhood Hits	198	Target Neighborhood Hits	348	Shared Neighborhood Hits	118
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ITSN2_MOUSE
θ value	0.0736092 (rank : 110)	NC score	0.215311 (rank : 129)
Query Neighborhood Hits	198	Target Neighborhood Hits	1371	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JIP2_HUMAN
θ value	0.0736092 (rank : 111)	NC score	0.131622 (rank : 171)
Query Neighborhood Hits	198	Target Neighborhood Hits	288	Shared Neighborhood Hits	53
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.0736092 (rank : 112)	NC score	0.136292 (rank : 166)
Query Neighborhood Hits	198	Target Neighborhood Hits	144	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MYO1E_HUMAN
θ value	0.0736092 (rank : 113)	NC score	0.152147 (rank : 158)
Query Neighborhood Hits	198	Target Neighborhood Hits	293	Shared Neighborhood Hits	125
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

RHG26_HUMAN
θ value	0.0736092 (rank : 114)	NC score	0.195548 (rank : 139)
Query Neighborhood Hits	198	Target Neighborhood Hits	281	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ES8L2_MOUSE
θ value	0.0961366 (rank : 115)	NC score	0.194611 (rank : 140)
Query Neighborhood Hits	198	Target Neighborhood Hits	169	Shared Neighborhood Hits	97
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

CRK_HUMAN
θ value	0.163984 (rank : 116)	NC score	0.304475 (rank : 72)
Query Neighborhood Hits	198	Target Neighborhood Hits	308	Shared Neighborhood Hits	130
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ES8L2_HUMAN
θ value	0.163984 (rank : 117)	NC score	0.197388 (rank : 138)
Query Neighborhood Hits	198	Target Neighborhood Hits	193	Shared Neighborhood Hits	99
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

GRAP2_HUMAN
θ value	0.163984 (rank : 118)	NC score	0.287503 (rank : 83)
Query Neighborhood Hits	198	Target Neighborhood Hits	304	Shared Neighborhood Hits	135
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

M3KL4_HUMAN
θ value	0.163984 (rank : 119)	NC score	0.082913 (rank : 212)
Query Neighborhood Hits	198	Target Neighborhood Hits	1087	Shared Neighborhood Hits	124
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SNX14_MOUSE
θ value	0.163984 (rank : 120)	NC score	0.234414 (rank : 114)
Query Neighborhood Hits	198	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

SNX20_MOUSE
θ value	0.163984 (rank : 121)	NC score	0.219011 (rank : 124)
Query Neighborhood Hits	198	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2Y5, Q544B6	Gene names	Snx20
Domain Architecture	No domain graphic available
Description	Sorting nexin-20.

SRC_HUMAN
θ value	0.163984 (rank : 122)	NC score	0.072824 (rank : 222)
Query Neighborhood Hits	198	Target Neighborhood Hits	1058	Shared Neighborhood Hits	131
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TXK_MOUSE
θ value	0.163984 (rank : 123)	NC score	0.051950 (rank : 265)
Query Neighborhood Hits	198	Target Neighborhood Hits	980	Shared Neighborhood Hits	104
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CASL_MOUSE
θ value	0.21417 (rank : 124)	NC score	0.247994 (rank : 106)
Query Neighborhood Hits	198	Target Neighborhood Hits	225	Shared Neighborhood Hits	116
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

GPS2_HUMAN
θ value	0.21417 (rank : 125)	NC score	0.068943 (rank : 228)
Query Neighborhood Hits	198	Target Neighborhood Hits	459	Shared Neighborhood Hits	13
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

OSTF1_HUMAN
θ value	0.21417 (rank : 126)	NC score	0.257006 (rank : 97)
Query Neighborhood Hits	198	Target Neighborhood Hits	466	Shared Neighborhood Hits	128
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SNX14_HUMAN
θ value	0.21417 (rank : 127)	NC score	0.237150 (rank : 112)
Query Neighborhood Hits	198	Target Neighborhood Hits	77	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

ABI3_MOUSE
θ value	0.279714 (rank : 128)	NC score	0.311526 (rank : 68)
Query Neighborhood Hits	198	Target Neighborhood Hits	227	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG6_HUMAN
θ value	0.279714 (rank : 129)	NC score	0.270351 (rank : 93)
Query Neighborhood Hits	198	Target Neighborhood Hits	376	Shared Neighborhood Hits	124
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CT032_HUMAN
θ value	0.279714 (rank : 130)	NC score	0.273681 (rank : 89)
Query Neighborhood Hits	198	Target Neighborhood Hits	235	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

IASPP_MOUSE
θ value	0.279714 (rank : 131)	NC score	0.133839 (rank : 169)
Query Neighborhood Hits	198	Target Neighborhood Hits	1024	Shared Neighborhood Hits	116
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MYH13_HUMAN
θ value	0.279714 (rank : 132)	NC score	0.029417 (rank : 274)
Query Neighborhood Hits	198	Target Neighborhood Hits	1504	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

BCAR1_MOUSE
θ value	0.365318 (rank : 133)	NC score	0.248389 (rank : 105)
Query Neighborhood Hits	198	Target Neighborhood Hits	438	Shared Neighborhood Hits	121
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NPHP1_HUMAN
θ value	0.365318 (rank : 134)	NC score	0.250647 (rank : 102)
Query Neighborhood Hits	198	Target Neighborhood Hits	288	Shared Neighborhood Hits	111
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SH3K1_HUMAN
θ value	0.365318 (rank : 135)	NC score	0.383318 (rank : 36)
Query Neighborhood Hits	198	Target Neighborhood Hits	341	Shared Neighborhood Hits	130
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.365318 (rank : 136)	NC score	0.382408 (rank : 37)
Query Neighborhood Hits	198	Target Neighborhood Hits	332	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

VAV3_HUMAN
θ value	0.365318 (rank : 137)	NC score	0.208887 (rank : 130)
Query Neighborhood Hits	198	Target Neighborhood Hits	398	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

AHI1_MOUSE
θ value	0.47712 (rank : 138)	NC score	0.221101 (rank : 122)
Query Neighborhood Hits	198	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG6_MOUSE
θ value	0.47712 (rank : 139)	NC score	0.278218 (rank : 85)
Query Neighborhood Hits	198	Target Neighborhood Hits	394	Shared Neighborhood Hits	126
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ES8L3_HUMAN
θ value	0.47712 (rank : 140)	NC score	0.204783 (rank : 132)
Query Neighborhood Hits	198	Target Neighborhood Hits	206	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SHLB1_HUMAN
θ value	0.47712 (rank : 141)	NC score	0.249191 (rank : 104)
Query Neighborhood Hits	198	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	0.47712 (rank : 142)	NC score	0.256065 (rank : 100)
Query Neighborhood Hits	198	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

VAV2_MOUSE
θ value	0.47712 (rank : 143)	NC score	0.223610 (rank : 119)
Query Neighborhood Hits	198	Target Neighborhood Hits	456	Shared Neighborhood Hits	128
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

GRB2_HUMAN
θ value	0.62314 (rank : 144)	NC score	0.298037 (rank : 77)
Query Neighborhood Hits	198	Target Neighborhood Hits	310	Shared Neighborhood Hits	134
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.62314 (rank : 145)	NC score	0.297375 (rank : 78)
Query Neighborhood Hits	198	Target Neighborhood Hits	312	Shared Neighborhood Hits	134
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

VAV2_HUMAN
θ value	0.62314 (rank : 146)	NC score	0.221974 (rank : 120)
Query Neighborhood Hits	198	Target Neighborhood Hits	453	Shared Neighborhood Hits	129
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ZBT7A_HUMAN
θ value	0.62314 (rank : 147)	NC score	-0.000564 (rank : 290)
Query Neighborhood Hits	198	Target Neighborhood Hits	823	Shared Neighborhood Hits	6
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

AHI1_HUMAN
θ value	0.813845 (rank : 148)	NC score	0.218128 (rank : 125)
Query Neighborhood Hits	198	Target Neighborhood Hits	537	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

DOCK1_HUMAN
θ value	0.813845 (rank : 149)	NC score	0.103644 (rank : 189)
Query Neighborhood Hits	198	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ES8L1_MOUSE
θ value	0.813845 (rank : 150)	NC score	0.171150 (rank : 145)
Query Neighborhood Hits	198	Target Neighborhood Hits	143	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

MISS_MOUSE
θ value	0.813845 (rank : 151)	NC score	0.030512 (rank : 273)
Query Neighborhood Hits	198	Target Neighborhood Hits	444	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

OSTF1_MOUSE
θ value	0.813845 (rank : 152)	NC score	0.244989 (rank : 108)
Query Neighborhood Hits	198	Target Neighborhood Hits	467	Shared Neighborhood Hits	129
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85B_HUMAN
θ value	0.813845 (rank : 153)	NC score	0.104068 (rank : 188)
Query Neighborhood Hits	198	Target Neighborhood Hits	543	Shared Neighborhood Hits	57
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SC24C_HUMAN
θ value	0.813845 (rank : 154)	NC score	0.021168 (rank : 278)
Query Neighborhood Hits	198	Target Neighborhood Hits	662	Shared Neighborhood Hits	14
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

VAV3_MOUSE
θ value	0.813845 (rank : 155)	NC score	0.200702 (rank : 135)
Query Neighborhood Hits	198	Target Neighborhood Hits	404	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ES8L1_HUMAN
θ value	1.06291 (rank : 156)	NC score	0.170621 (rank : 146)
Query Neighborhood Hits	198	Target Neighborhood Hits	162	Shared Neighborhood Hits	77
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

NCK2_HUMAN
θ value	1.06291 (rank : 157)	NC score	0.267953 (rank : 95)
Query Neighborhood Hits	198	Target Neighborhood Hits	310	Shared Neighborhood Hits	133
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NPHP1_MOUSE
θ value	1.06291 (rank : 158)	NC score	0.263391 (rank : 96)
Query Neighborhood Hits	198	Target Neighborhood Hits	267	Shared Neighborhood Hits	116
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

RIMB2_HUMAN
θ value	1.06291 (rank : 159)	NC score	0.215516 (rank : 128)
Query Neighborhood Hits	198	Target Neighborhood Hits	263	Shared Neighborhood Hits	95
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

TXK_HUMAN
θ value	1.06291 (rank : 160)	NC score	0.043125 (rank : 271)
Query Neighborhood Hits	198	Target Neighborhood Hits	971	Shared Neighborhood Hits	92
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CASL_HUMAN
θ value	1.38821 (rank : 161)	NC score	0.241165 (rank : 109)
Query Neighborhood Hits	198	Target Neighborhood Hits	259	Shared Neighborhood Hits	113
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

GLI2_HUMAN
θ value	1.38821 (rank : 162)	NC score	-0.000724 (rank : 291)
Query Neighborhood Hits	198	Target Neighborhood Hits	971	Shared Neighborhood Hits	11
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

P3C2A_HUMAN
θ value	1.38821 (rank : 163)	NC score	0.043301 (rank : 270)
Query Neighborhood Hits	198	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

SNX17_MOUSE
θ value	1.38821 (rank : 164)	NC score	0.130495 (rank : 173)
Query Neighborhood Hits	198	Target Neighborhood Hits	34	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BVL3, Q8R0N8	Gene names	Snx17
Domain Architecture	No domain graphic available
Description	Sorting nexin-17.

EGFL7_HUMAN
θ value	1.81305 (rank : 165)	NC score	0.007412 (rank : 287)
Query Neighborhood Hits	198	Target Neighborhood Hits	325	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

ES8L3_MOUSE
θ value	1.81305 (rank : 166)	NC score	0.221365 (rank : 121)
Query Neighborhood Hits	198	Target Neighborhood Hits	168	Shared Neighborhood Hits	104
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

M3K10_HUMAN
θ value	1.81305 (rank : 167)	NC score	0.063848 (rank : 239)
Query Neighborhood Hits	198	Target Neighborhood Hits	1071	Shared Neighborhood Hits	113
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

P3C2A_MOUSE
θ value	1.81305 (rank : 168)	NC score	0.042412 (rank : 272)
Query Neighborhood Hits	198	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

ECEL1_MOUSE
θ value	2.36792 (rank : 169)	NC score	0.010163 (rank : 282)
Query Neighborhood Hits	198	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

SPN90_HUMAN
θ value	2.36792 (rank : 170)	NC score	0.145857 (rank : 162)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

STAC_HUMAN
θ value	2.36792 (rank : 171)	NC score	0.274419 (rank : 88)
Query Neighborhood Hits	198	Target Neighborhood Hits	276	Shared Neighborhood Hits	120
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRIP1_MOUSE
θ value	3.0926 (rank : 172)	NC score	0.009885 (rank : 283)
Query Neighborhood Hits	198	Target Neighborhood Hits	241	Shared Neighborhood Hits	4
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

RUSC1_HUMAN
θ value	3.0926 (rank : 173)	NC score	0.185297 (rank : 142)
Query Neighborhood Hits	198	Target Neighborhood Hits	226	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SHLB2_HUMAN
θ value	3.0926 (rank : 174)	NC score	0.224585 (rank : 118)
Query Neighborhood Hits	198	Target Neighborhood Hits	86	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	3.0926 (rank : 175)	NC score	0.225824 (rank : 117)
Query Neighborhood Hits	198	Target Neighborhood Hits	88	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SPN90_MOUSE
θ value	3.0926 (rank : 176)	NC score	0.129456 (rank : 175)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRMS_MOUSE
θ value	3.0926 (rank : 177)	NC score	0.028943 (rank : 275)
Query Neighborhood Hits	198	Target Neighborhood Hits	964	Shared Neighborhood Hits	78
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

CABIN_HUMAN
θ value	4.03905 (rank : 178)	NC score	0.026083 (rank : 277)
Query Neighborhood Hits	198	Target Neighborhood Hits	490	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

GLIS3_MOUSE
θ value	4.03905 (rank : 179)	NC score	-0.002939 (rank : 293)
Query Neighborhood Hits	198	Target Neighborhood Hits	861	Shared Neighborhood Hits	9
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

K1802_HUMAN
θ value	4.03905 (rank : 180)	NC score	0.007500 (rank : 286)
Query Neighborhood Hits	198	Target Neighborhood Hits	1378	Shared Neighborhood Hits	26
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

PLCG1_MOUSE
θ value	4.03905 (rank : 181)	NC score	0.179205 (rank : 143)
Query Neighborhood Hits	198	Target Neighborhood Hits	314	Shared Neighborhood Hits	111
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RIMB1_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.116467 (rank : 179)
Query Neighborhood Hits	198	Target Neighborhood Hits	1479	Shared Neighborhood Hits	107
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	4.03905 (rank : 183)	NC score	0.104173 (rank : 187)
Query Neighborhood Hits	198	Target Neighborhood Hits	1376	Shared Neighborhood Hits	110
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

AMBN_HUMAN
θ value	5.27518 (rank : 184)	NC score	0.016898 (rank : 279)
Query Neighborhood Hits	198	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NP70, Q9H2X1, Q9H4L1	Gene names	AMBN
Domain Architecture
Description	Ameloblastin precursor.

CSKI1_MOUSE
θ value	5.27518 (rank : 185)	NC score	0.015215 (rank : 280)
Query Neighborhood Hits	198	Target Neighborhood Hits	1031	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FGR_MOUSE
θ value	5.27518 (rank : 186)	NC score	0.066368 (rank : 235)
Query Neighborhood Hits	198	Target Neighborhood Hits	1069	Shared Neighborhood Hits	130
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PASK_HUMAN
θ value	5.27518 (rank : 187)	NC score	0.003291 (rank : 289)
Query Neighborhood Hits	198	Target Neighborhood Hits	857	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

FYN_HUMAN
θ value	6.88961 (rank : 188)	NC score	0.068679 (rank : 229)
Query Neighborhood Hits	198	Target Neighborhood Hits	1078	Shared Neighborhood Hits	130
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	6.88961 (rank : 189)	NC score	0.069883 (rank : 227)
Query Neighborhood Hits	198	Target Neighborhood Hits	1073	Shared Neighborhood Hits	130
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SNX17_HUMAN
θ value	6.88961 (rank : 190)	NC score	0.112067 (rank : 181)
Query Neighborhood Hits	198	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	Q15036, Q53HN7, Q6IAS3	Gene names	SNX17, KIAA0064
Domain Architecture
Description	Sorting nexin-17.

SSBP4_HUMAN
θ value	6.88961 (rank : 191)	NC score	0.011448 (rank : 281)
Query Neighborhood Hits	198	Target Neighborhood Hits	753	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

STAC_MOUSE
θ value	6.88961 (rank : 192)	NC score	0.256814 (rank : 99)
Query Neighborhood Hits	198	Target Neighborhood Hits	268	Shared Neighborhood Hits	115
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GPR98_HUMAN
θ value	8.99809 (rank : 193)	NC score	0.008781 (rank : 285)
Query Neighborhood Hits	198	Target Neighborhood Hits	202	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

MAVS_MOUSE
θ value	8.99809 (rank : 194)	NC score	0.027794 (rank : 276)
Query Neighborhood Hits	198	Target Neighborhood Hits	170	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

NOTC2_MOUSE
θ value	8.99809 (rank : 195)	NC score	-0.002317 (rank : 292)
Query Neighborhood Hits	198	Target Neighborhood Hits	1069	Shared Neighborhood Hits	14
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NRX2A_HUMAN
θ value	8.99809 (rank : 196)	NC score	0.004957 (rank : 288)
Query Neighborhood Hits	198	Target Neighborhood Hits	614	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	8.99809 (rank : 197)	NC score	0.009114 (rank : 284)
Query Neighborhood Hits	198	Target Neighborhood Hits	481	Shared Neighborhood Hits	13
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

P85B_MOUSE
θ value	8.99809 (rank : 198)	NC score	0.091224 (rank : 198)
Query Neighborhood Hits	198	Target Neighborhood Hits	519	Shared Neighborhood Hits	52
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

AMPH_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.081876 (rank : 215)
Query Neighborhood Hits	198	Target Neighborhood Hits	455	Shared Neighborhood Hits	65
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.071685 (rank : 223)
Query Neighborhood Hits	198	Target Neighborhood Hits	291	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.111303 (rank : 182)
Query Neighborhood Hits	198	Target Neighborhood Hits	175	Shared Neighborhood Hits	101
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.106072 (rank : 185)
Query Neighborhood Hits	198	Target Neighborhood Hits	175	Shared Neighborhood Hits	101
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG3_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.066458 (rank : 233)
Query Neighborhood Hits	198	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.066400 (rank : 234)
Query Neighborhood Hits	198	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.176456 (rank : 144)
Query Neighborhood Hits	198	Target Neighborhood Hits	242	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.134663 (rank : 168)
Query Neighborhood Hits	198	Target Neighborhood Hits	185	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG8_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.061065 (rank : 246)
Query Neighborhood Hits	198	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.064126 (rank : 238)
Query Neighborhood Hits	198	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.160072 (rank : 155)
Query Neighborhood Hits	198	Target Neighborhood Hits	235	Shared Neighborhood Hits	104
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.160277 (rank : 154)
Query Neighborhood Hits	198	Target Neighborhood Hits	234	Shared Neighborhood Hits	104
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.052908 (rank : 261)
Query Neighborhood Hits	198	Target Neighborhood Hits	187	Shared Neighborhood Hits	18
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.055182 (rank : 255)
Query Neighborhood Hits	198	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.070894 (rank : 225)
Query Neighborhood Hits	198	Target Neighborhood Hits	129	Shared Neighborhood Hits	34
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.086393 (rank : 206)
Query Neighborhood Hits	198	Target Neighborhood Hits	152	Shared Neighborhood Hits	46
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.116450 (rank : 180)
Query Neighborhood Hits	198	Target Neighborhood Hits	956	Shared Neighborhood Hits	118
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.116473 (rank : 178)
Query Neighborhood Hits	198	Target Neighborhood Hits	1244	Shared Neighborhood Hits	123
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.091125 (rank : 199)
Query Neighborhood Hits	198	Target Neighborhood Hits	1156	Shared Neighborhood Hits	101
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.101604 (rank : 191)
Query Neighborhood Hits	198	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.103380 (rank : 190)
Query Neighborhood Hits	198	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BI2L1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.093025 (rank : 197)
Query Neighborhood Hits	198	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.089013 (rank : 200)
Query Neighborhood Hits	198	Target Neighborhood Hits	197	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.078946 (rank : 218)
Query Neighborhood Hits	198	Target Neighborhood Hits	335	Shared Neighborhood Hits	57
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.079690 (rank : 217)
Query Neighborhood Hits	198	Target Neighborhood Hits	283	Shared Neighborhood Hits	62
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BTK_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.059169 (rank : 250)
Query Neighborhood Hits	198	Target Neighborhood Hits	1026	Shared Neighborhood Hits	128
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.056001 (rank : 251)
Query Neighborhood Hits	198	Target Neighborhood Hits	1017	Shared Neighborhood Hits	124
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ECT2_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.052890 (rank : 262)
Query Neighborhood Hits	198	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.054903 (rank : 257)
Query Neighborhood Hits	198	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.053436 (rank : 260)
Query Neighborhood Hits	198	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.051452 (rank : 266)
Query Neighborhood Hits	198	Target Neighborhood Hits	221	Shared Neighborhood Hits	64
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

FGR_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.067381 (rank : 231)
Query Neighborhood Hits	198	Target Neighborhood Hits	1067	Shared Neighborhood Hits	127
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FNBP2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.105590 (rank : 186)
Query Neighborhood Hits	198	Target Neighborhood Hits	432	Shared Neighborhood Hits	104
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

HCK_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.054412 (rank : 258)
Query Neighborhood Hits	198	Target Neighborhood Hits	1035	Shared Neighborhood Hits	125
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.054258 (rank : 259)
Query Neighborhood Hits	198	Target Neighborhood Hits	1029	Shared Neighborhood Hits	124
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

IASPP_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.132754 (rank : 170)
Query Neighborhood Hits	198	Target Neighborhood Hits	688	Shared Neighborhood Hits	112
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JIP1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.075236 (rank : 220)
Query Neighborhood Hits	198	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.074394 (rank : 221)
Query Neighborhood Hits	198	Target Neighborhood Hits	259	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

M3K11_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.065068 (rank : 237)
Query Neighborhood Hits	198	Target Neighborhood Hits	1136	Shared Neighborhood Hits	113
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.061566 (rank : 244)
Query Neighborhood Hits	198	Target Neighborhood Hits	1123	Shared Neighborhood Hits	119
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MCF2L_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.063031 (rank : 241)
Query Neighborhood Hits	198	Target Neighborhood Hits	255	Shared Neighborhood Hits	31
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.052256 (rank : 264)
Query Neighborhood Hits	198	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NCF1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.238178 (rank : 110)
Query Neighborhood Hits	198	Target Neighborhood Hits	198	Shared Neighborhood Hits	116
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.245177 (rank : 107)
Query Neighborhood Hits	198	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.314069 (rank : 67)
Query Neighborhood Hits	198	Target Neighborhood Hits	229	Shared Neighborhood Hits	119
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK1_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.252795 (rank : 101)
Query Neighborhood Hits	198	Target Neighborhood Hits	312	Shared Neighborhood Hits	131
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NGEF_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.100303 (rank : 193)
Query Neighborhood Hits	198	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.101229 (rank : 192)
Query Neighborhood Hits	198	Target Neighborhood Hits	228	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.087251 (rank : 202)
Query Neighborhood Hits	198	Target Neighborhood Hits	100	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.130356 (rank : 174)
Query Neighborhood Hits	198	Target Neighborhood Hits	114	Shared Neighborhood Hits	78
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

P55G_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.070486 (rank : 226)
Query Neighborhood Hits	198	Target Neighborhood Hits	451	Shared Neighborhood Hits	38
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.070974 (rank : 224)
Query Neighborhood Hits	198	Target Neighborhood Hits	401	Shared Neighborhood Hits	38
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PKHG1_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.067528 (rank : 230)
Query Neighborhood Hits	198	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.165115 (rank : 152)
Query Neighborhood Hits	198	Target Neighborhood Hits	293	Shared Neighborhood Hits	106
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.165736 (rank : 151)
Query Neighborhood Hits	198	Target Neighborhood Hits	280	Shared Neighborhood Hits	110
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP2_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.094506 (rank : 196)
Query Neighborhood Hits	198	Target Neighborhood Hits	254	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.085162 (rank : 209)
Query Neighborhood Hits	198	Target Neighborhood Hits	308	Shared Neighborhood Hits	18
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.060898 (rank : 247)
Query Neighborhood Hits	198	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.055990 (rank : 252)
Query Neighborhood Hits	198	Target Neighborhood Hits	258	Shared Neighborhood Hits	43
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG04_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.136004 (rank : 167)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	112
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB2_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.192611 (rank : 141)
Query Neighborhood Hits	198	Target Neighborhood Hits	246	Shared Neighborhood Hits	85
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.157263 (rank : 156)
Query Neighborhood Hits	198	Target Neighborhood Hits	206	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.055651 (rank : 253)
Query Neighborhood Hits	198	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.050392 (rank : 267)
Query Neighborhood Hits	198	Target Neighborhood Hits	305	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SHAN1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.063799 (rank : 240)
Query Neighborhood Hits	198	Target Neighborhood Hits	1041	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.085057 (rank : 210)
Query Neighborhood Hits	198	Target Neighborhood Hits	446	Shared Neighborhood Hits	80
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLAP2_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.054993 (rank : 256)
Query Neighborhood Hits	198	Target Neighborhood Hits	139	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.055513 (rank : 254)
Query Neighborhood Hits	198	Target Neighborhood Hits	136	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.066305 (rank : 236)
Query Neighborhood Hits	198	Target Neighborhood Hits	81	Shared Neighborhood Hits	46
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.078595 (rank : 219)
Query Neighborhood Hits	198	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX19_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.137932 (rank : 164)
Query Neighborhood Hits	198	Target Neighborhood Hits	123	Shared Neighborhood Hits	30
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

SNX21_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.087031 (rank : 204)
Query Neighborhood Hits	198	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q969T3, Q5JZH6, Q9BR16	Gene names	SNX21, C20orf161, SNXL
Domain Architecture
Description	Sorting nexin-21 (Sorting nexin L) (SNX-L).

SNX22_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.059486 (rank : 249)
Query Neighborhood Hits	198	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	Q96L94, Q9H844	Gene names	SNX22
Domain Architecture
Description	Sorting nexin-22.

SNX24_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.086943 (rank : 205)
Query Neighborhood Hits	198	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y343, Q6UY33	Gene names	SNX24
Domain Architecture
Description	Sorting nexin-24.

SNX24_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.087211 (rank : 203)
Query Neighborhood Hits	198	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CRB0	Gene names	Snx24
Domain Architecture	No domain graphic available
Description	Sorting nexin-24.

SNX25_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.084758 (rank : 211)
Query Neighborhood Hits	198	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3E2	Gene names	SNX25
Domain Architecture
Description	Sorting nexin-25.

SNX5_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.098597 (rank : 194)
Query Neighborhood Hits	198	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5X3, Q52LC4, Q9BWP0	Gene names	SNX5
Domain Architecture
Description	Sorting nexin-5.

SNX5_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.096474 (rank : 195)
Query Neighborhood Hits	198	Target Neighborhood Hits	81	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D8U8, Q543N9	Gene names	Snx5
Domain Architecture
Description	Sorting nexin-5.

SNX6_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.085599 (rank : 207)
Query Neighborhood Hits	198	Target Neighborhood Hits	52	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UNH7, Q9Y449	Gene names	SNX6
Domain Architecture
Description	Sorting nexin-6 (TRAF4-associated factor 2).

SNX6_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.085401 (rank : 208)
Query Neighborhood Hits	198	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	Q6P8X1	Gene names	Snx6
Domain Architecture	No domain graphic available
Description	Sorting nexin-6.

SRC_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.052800 (rank : 263)
Query Neighborhood Hits	198	Target Neighborhood Hits	1033	Shared Neighborhood Hits	121
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP1_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.110913 (rank : 183)
Query Neighborhood Hits	198	Target Neighborhood Hits	390	Shared Neighborhood Hits	102
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.117605 (rank : 177)
Query Neighborhood Hits	198	Target Neighborhood Hits	331	Shared Neighborhood Hits	103
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.119348 (rank : 176)
Query Neighborhood Hits	198	Target Neighborhood Hits	324	Shared Neighborhood Hits	104
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.204611 (rank : 133)
Query Neighborhood Hits	198	Target Neighborhood Hits	228	Shared Neighborhood Hits	103
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.205905 (rank : 131)
Query Neighborhood Hits	198	Target Neighborhood Hits	232	Shared Neighborhood Hits	103
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STS1_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.081572 (rank : 216)
Query Neighborhood Hits	198	Target Neighborhood Hits	106	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.082436 (rank : 214)
Query Neighborhood Hits	198	Target Neighborhood Hits	104	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.109868 (rank : 184)
Query Neighborhood Hits	198	Target Neighborhood Hits	108	Shared Neighborhood Hits	65
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCGAP_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.082852 (rank : 213)
Query Neighborhood Hits	198	Target Neighborhood Hits	872	Shared Neighborhood Hits	96
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.088829 (rank : 201)
Query Neighborhood Hits	198	Target Neighborhood Hits	409	Shared Neighborhood Hits	93
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TIAM1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.060317 (rank : 248)
Query Neighborhood Hits	198	Target Neighborhood Hits	225	Shared Neighborhood Hits	18
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.062782 (rank : 242)
Query Neighborhood Hits	198	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

YES_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.061480 (rank : 245)
Query Neighborhood Hits	198	Target Neighborhood Hits	1059	Shared Neighborhood Hits	125
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.062741 (rank : 243)
Query Neighborhood Hits	198	Target Neighborhood Hits	1052	Shared Neighborhood Hits	125
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

Hits sorted by NC score

SNX18_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	198	Target Neighborhood Hits	198	Shared Neighborhood Hits	198
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.993271 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	198	Target Neighborhood Hits	207	Shared Neighborhood Hits	185
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
NC score	0.857767 (rank : 3)	θ value	1.14825e-79 (rank : 4)
Query Neighborhood Hits	198	Target Neighborhood Hits	148	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
NC score	0.849666 (rank : 4)	θ value	1.03855e-80 (rank : 3)
Query Neighborhood Hits	198	Target Neighborhood Hits	141	Shared Neighborhood Hits	115
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SNX7_HUMAN
NC score	0.480893 (rank : 5)	θ value	3.89403e-11 (rank : 5)
Query Neighborhood Hits	198	Target Neighborhood Hits	79	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UNH6, Q86U82, Q8WVD4, Q96FW9, Q9Y3Z7	Gene names	SNX7
Domain Architecture
Description	Sorting nexin-7.

SNX7_MOUSE
NC score	0.474912 (rank : 6)	θ value	5.08577e-11 (rank : 6)
Query Neighborhood Hits	198	Target Neighborhood Hits	89	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CY18	Gene names	Snx7
Domain Architecture
Description	Sorting nexin-7.

SH3G3_MOUSE
NC score	0.472075 (rank : 7)	θ value	5.81887e-07 (rank : 10)
Query Neighborhood Hits	198	Target Neighborhood Hits	236	Shared Neighborhood Hits	132
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SNX8_HUMAN
NC score	0.470445 (rank : 8)	θ value	1.63604e-09 (rank : 7)
Query Neighborhood Hits	198	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

SH3G3_HUMAN
NC score	0.464668 (rank : 9)	θ value	2.88788e-06 (rank : 15)
Query Neighborhood Hits	198	Target Neighborhood Hits	222	Shared Neighborhood Hits	127
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G2_HUMAN
NC score	0.456032 (rank : 10)	θ value	3.77169e-06 (rank : 17)
Query Neighborhood Hits	198	Target Neighborhood Hits	324	Shared Neighborhood Hits	129
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
NC score	0.453148 (rank : 11)	θ value	1.09739e-05 (rank : 25)
Query Neighborhood Hits	198	Target Neighborhood Hits	319	Shared Neighborhood Hits	131
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G1_MOUSE
NC score	0.448196 (rank : 12)	θ value	9.92553e-07 (rank : 14)
Query Neighborhood Hits	198	Target Neighborhood Hits	291	Shared Neighborhood Hits	127
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SNX8_MOUSE
NC score	0.446482 (rank : 13)	θ value	1.17247e-07 (rank : 8)
Query Neighborhood Hits	198	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFD4, Q8BLI6, Q8BUQ7	Gene names	Snx8
Domain Architecture	No domain graphic available
Description	Sorting nexin-8.

SH3G1_HUMAN
NC score	0.445256 (rank : 14)	θ value	4.92598e-06 (rank : 21)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	128
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

PACN2_HUMAN
NC score	0.439233 (rank : 15)	θ value	4.92598e-06 (rank : 20)
Query Neighborhood Hits	198	Target Neighborhood Hits	339	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_MOUSE
NC score	0.439152 (rank : 16)	θ value	4.92598e-06 (rank : 19)
Query Neighborhood Hits	198	Target Neighborhood Hits	283	Shared Neighborhood Hits	131
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

VINEX_MOUSE
NC score	0.438752 (rank : 17)	θ value	9.29e-05 (rank : 34)
Query Neighborhood Hits	198	Target Neighborhood Hits	286	Shared Neighborhood Hits	138
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.438354 (rank : 18)	θ value	0.00020696 (rank : 39)
Query Neighborhood Hits	198	Target Neighborhood Hits	270	Shared Neighborhood Hits	136
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PACN1_HUMAN
NC score	0.436486 (rank : 19)	θ value	4.92598e-06 (rank : 18)
Query Neighborhood Hits	198	Target Neighborhood Hits	320	Shared Neighborhood Hits	131
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
NC score	0.436047 (rank : 20)	θ value	6.43352e-06 (rank : 22)
Query Neighborhood Hits	198	Target Neighborhood Hits	382	Shared Neighborhood Hits	133
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SNX12_MOUSE
NC score	0.428833 (rank : 21)	θ value	2.88788e-06 (rank : 16)
Query Neighborhood Hits	198	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	O70493, Q9D0N3	Gene names	Snx12
Domain Architecture
Description	Sorting nexin-12 (SDP8 protein).

PACN3_MOUSE
NC score	0.428452 (rank : 22)	θ value	9.92553e-07 (rank : 13)
Query Neighborhood Hits	198	Target Neighborhood Hits	380	Shared Neighborhood Hits	127
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.426563 (rank : 23)	θ value	9.92553e-07 (rank : 12)
Query Neighborhood Hits	198	Target Neighborhood Hits	385	Shared Neighborhood Hits	126
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NCF4_MOUSE
NC score	0.425867 (rank : 24)	θ value	0.000786445 (rank : 45)
Query Neighborhood Hits	198	Target Neighborhood Hits	177	Shared Neighborhood Hits	130
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SNX4_HUMAN
NC score	0.417154 (rank : 25)	θ value	1.99992e-07 (rank : 9)
Query Neighborhood Hits	198	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	O95219	Gene names	SNX4
Domain Architecture
Description	Sorting nexin-4.

SNX4_MOUSE
NC score	0.415955 (rank : 26)	θ value	5.81887e-07 (rank : 11)
Query Neighborhood Hits	198	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q91YJ2	Gene names	Snx4
Domain Architecture	No domain graphic available
Description	Sorting nexin-4.

SNX12_HUMAN
NC score	0.407792 (rank : 27)	θ value	4.1701e-05 (rank : 29)
Query Neighborhood Hits	198	Target Neighborhood Hits	46	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UMY4, Q8WUG9	Gene names	SNX12
Domain Architecture
Description	Sorting nexin-12.

SNX11_HUMAN
NC score	0.405846 (rank : 28)	θ value	8.40245e-06 (rank : 23)
Query Neighborhood Hits	198	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5W9, Q9H885	Gene names	SNX11
Domain Architecture
Description	Sorting nexin-11.

SNX3_MOUSE
NC score	0.405028 (rank : 29)	θ value	2.44474e-05 (rank : 28)
Query Neighborhood Hits	198	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	O70492	Gene names	Snx3
Domain Architecture
Description	Sorting nexin-3 (SDP3 protein).

CD2AP_MOUSE
NC score	0.403839 (rank : 30)	θ value	0.00020696 (rank : 37)
Query Neighborhood Hits	198	Target Neighborhood Hits	336	Shared Neighborhood Hits	131
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NCF4_HUMAN
NC score	0.403537 (rank : 31)	θ value	0.00228821 (rank : 55)
Query Neighborhood Hits	198	Target Neighborhood Hits	161	Shared Neighborhood Hits	122
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SNX3_HUMAN
NC score	0.398758 (rank : 32)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	198	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	O60493, O60718, Q5JXJ7, Q5JXJ8, Q96AP9, Q9C0J5, Q9NU45	Gene names	SNX3
Domain Architecture
Description	Sorting nexin-3 (Protein SDP3).

SNX11_MOUSE
NC score	0.397618 (rank : 33)	θ value	2.44474e-05 (rank : 27)
Query Neighborhood Hits	198	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	Q91WL6, Q3V3A6	Gene names	Snx11
Domain Architecture	No domain graphic available
Description	Sorting nexin-11.

CD2AP_HUMAN
NC score	0.394282 (rank : 34)	θ value	0.00175202 (rank : 52)
Query Neighborhood Hits	198	Target Neighborhood Hits	315	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SRBS1_HUMAN
NC score	0.386552 (rank : 35)	θ value	0.00665767 (rank : 72)
Query Neighborhood Hits	198	Target Neighborhood Hits	396	Shared Neighborhood Hits	133
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3K1_HUMAN
NC score	0.383318 (rank : 36)	θ value	0.365318 (rank : 135)
Query Neighborhood Hits	198	Target Neighborhood Hits	341	Shared Neighborhood Hits	130
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.382408 (rank : 37)	θ value	0.365318 (rank : 136)
Query Neighborhood Hits	198	Target Neighborhood Hits	332	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_MOUSE
NC score	0.378016 (rank : 38)	θ value	0.00869519 (rank : 76)
Query Neighborhood Hits	198	Target Neighborhood Hits	409	Shared Neighborhood Hits	134
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

DBNL_HUMAN
NC score	0.374669 (rank : 39)	θ value	0.00102713 (rank : 47)
Query Neighborhood Hits	198	Target Neighborhood Hits	244	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PPIP1_MOUSE
NC score	0.370800 (rank : 40)	θ value	0.0563607 (rank : 104)
Query Neighborhood Hits	198	Target Neighborhood Hits	377	Shared Neighborhood Hits	140
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

HCLS1_MOUSE
NC score	0.370693 (rank : 41)	θ value	0.00509761 (rank : 68)
Query Neighborhood Hits	198	Target Neighborhood Hits	329	Shared Neighborhood Hits	120
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.370061 (rank : 42)	θ value	0.00869519 (rank : 74)
Query Neighborhood Hits	198	Target Neighborhood Hits	358	Shared Neighborhood Hits	119
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

DBNL_MOUSE
NC score	0.369931 (rank : 43)	θ value	0.00102713 (rank : 48)
Query Neighborhood Hits	198	Target Neighborhood Hits	306	Shared Neighborhood Hits	120
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SNX2_HUMAN
NC score	0.367952 (rank : 44)	θ value	7.1131e-05 (rank : 32)
Query Neighborhood Hits	198	Target Neighborhood Hits	151	Shared Neighborhood Hits	40
SwissProt Accessions	O60749, O43650, P82862, Q53XK8, Q597H6, Q9BTS8	Gene names	SNX2, TRG9
Domain Architecture
Description	Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9).

SRC8_MOUSE
NC score	0.367315 (rank : 45)	θ value	0.0193708 (rank : 88)
Query Neighborhood Hits	198	Target Neighborhood Hits	292	Shared Neighborhood Hits	126
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SNX2_MOUSE
NC score	0.366915 (rank : 46)	θ value	5.44631e-05 (rank : 31)
Query Neighborhood Hits	198	Target Neighborhood Hits	156	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CWK8, Q3UKW3, Q9CQV0	Gene names	Snx2
Domain Architecture
Description	Sorting nexin-2.

PPIP1_HUMAN
NC score	0.366125 (rank : 47)	θ value	0.00509761 (rank : 69)
Query Neighborhood Hits	198	Target Neighborhood Hits	389	Shared Neighborhood Hits	139
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SRC8_HUMAN
NC score	0.365522 (rank : 48)	θ value	0.0431538 (rank : 99)
Query Neighborhood Hits	198	Target Neighborhood Hits	269	Shared Neighborhood Hits	127
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ABI2_MOUSE
NC score	0.364883 (rank : 49)	θ value	0.00509761 (rank : 66)
Query Neighborhood Hits	198	Target Neighborhood Hits	266	Shared Neighborhood Hits	119
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

STAM2_MOUSE
NC score	0.363911 (rank : 50)	θ value	0.00102713 (rank : 50)
Query Neighborhood Hits	198	Target Neighborhood Hits	285	Shared Neighborhood Hits	129
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ABI2_HUMAN
NC score	0.360600 (rank : 51)	θ value	0.00509761 (rank : 65)
Query Neighborhood Hits	198	Target Neighborhood Hits	350	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI1_MOUSE
NC score	0.357471 (rank : 52)	θ value	0.00509761 (rank : 64)
Query Neighborhood Hits	198	Target Neighborhood Hits	246	Shared Neighborhood Hits	116
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SNX1_HUMAN
NC score	0.353806 (rank : 53)	θ value	8.40245e-06 (rank : 24)
Query Neighborhood Hits	198	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

SNX1_MOUSE
NC score	0.351114 (rank : 54)	θ value	1.87187e-05 (rank : 26)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

STAM2_HUMAN
NC score	0.350936 (rank : 55)	θ value	0.00509761 (rank : 70)
Query Neighborhood Hits	198	Target Neighborhood Hits	288	Shared Neighborhood Hits	131
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM1_MOUSE
NC score	0.348324 (rank : 56)	θ value	0.0431538 (rank : 100)
Query Neighborhood Hits	198	Target Neighborhood Hits	273	Shared Neighborhood Hits	133
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.348278 (rank : 57)	θ value	0.0330416 (rank : 96)
Query Neighborhood Hits	198	Target Neighborhood Hits	271	Shared Neighborhood Hits	132
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI1_HUMAN
NC score	0.342196 (rank : 58)	θ value	0.0148317 (rank : 80)
Query Neighborhood Hits	198	Target Neighborhood Hits	257	Shared Neighborhood Hits	115
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI3_HUMAN
NC score	0.340855 (rank : 59)	θ value	0.0736092 (rank : 107)
Query Neighborhood Hits	198	Target Neighborhood Hits	227	Shared Neighborhood Hits	104
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

LASP1_HUMAN
NC score	0.338446 (rank : 60)	θ value	0.00390308 (rank : 61)
Query Neighborhood Hits	198	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.336379 (rank : 61)	θ value	0.00390308 (rank : 62)
Query Neighborhood Hits	198	Target Neighborhood Hits	297	Shared Neighborhood Hits	120
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CRKL_HUMAN
NC score	0.330657 (rank : 62)	θ value	0.00390308 (rank : 60)
Query Neighborhood Hits	198	Target Neighborhood Hits	313	Shared Neighborhood Hits	132
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
NC score	0.327305 (rank : 63)	θ value	0.000121331 (rank : 35)
Query Neighborhood Hits	198	Target Neighborhood Hits	314	Shared Neighborhood Hits	129
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

EFS_MOUSE
NC score	0.321682 (rank : 64)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	198	Target Neighborhood Hits	389	Shared Neighborhood Hits	121
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

CRKL_MOUSE
NC score	0.319498 (rank : 65)	θ value	0.0252991 (rank : 90)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PEX13_HUMAN
NC score	0.314549 (rank : 66)	θ value	0.0193708 (rank : 85)
Query Neighborhood Hits	198	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

NCF2_HUMAN
NC score	0.314069 (rank : 67)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	198	Target Neighborhood Hits	229	Shared Neighborhood Hits	119
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ABI3_MOUSE
NC score	0.311526 (rank : 68)	θ value	0.279714 (rank : 128)
Query Neighborhood Hits	198	Target Neighborhood Hits	227	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SNX10_HUMAN
NC score	0.310730 (rank : 69)	θ value	0.0330416 (rank : 93)
Query Neighborhood Hits	198	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5X0	Gene names	SNX10
Domain Architecture
Description	Sorting nexin-10.

SNX10_MOUSE
NC score	0.306373 (rank : 70)	θ value	0.0330416 (rank : 94)
Query Neighborhood Hits	198	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CWT3, Q8C1E0	Gene names	Snx10
Domain Architecture	No domain graphic available
Description	Sorting nexin-10.

PEX13_MOUSE
NC score	0.304732 (rank : 71)	θ value	0.0252991 (rank : 91)
Query Neighborhood Hits	198	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CRK_HUMAN
NC score	0.304475 (rank : 72)	θ value	0.163984 (rank : 116)
Query Neighborhood Hits	198	Target Neighborhood Hits	308	Shared Neighborhood Hits	130
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DNMBP_HUMAN
NC score	0.303861 (rank : 73)	θ value	0.0193708 (rank : 84)
Query Neighborhood Hits	198	Target Neighborhood Hits	413	Shared Neighborhood Hits	138
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.300204 (rank : 74)	θ value	0.0563607 (rank : 101)
Query Neighborhood Hits	198	Target Neighborhood Hits	435	Shared Neighborhood Hits	138
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRAP2_MOUSE
NC score	0.298706 (rank : 75)	θ value	0.0431538 (rank : 97)
Query Neighborhood Hits	198	Target Neighborhood Hits	297	Shared Neighborhood Hits	134
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ARHG7_MOUSE
NC score	0.298448 (rank : 76)	θ value	0.0252991 (rank : 89)
Query Neighborhood Hits	198	Target Neighborhood Hits	396	Shared Neighborhood Hits	128
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRB2_HUMAN
NC score	0.298037 (rank : 77)	θ value	0.62314 (rank : 144)
Query Neighborhood Hits	198	Target Neighborhood Hits	310	Shared Neighborhood Hits	134
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.297375 (rank : 78)	θ value	0.62314 (rank : 145)
Query Neighborhood Hits	198	Target Neighborhood Hits	312	Shared Neighborhood Hits	134
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

EFS_HUMAN
NC score	0.295134 (rank : 79)	θ value	0.0736092 (rank : 109)
Query Neighborhood Hits	198	Target Neighborhood Hits	348	Shared Neighborhood Hits	118
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

GRAP_MOUSE
NC score	0.292401 (rank : 80)	θ value	0.00869519 (rank : 73)
Query Neighborhood Hits	198	Target Neighborhood Hits	309	Shared Neighborhood Hits	136
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NEBL_HUMAN
NC score	0.291661 (rank : 81)	θ value	0.0563607 (rank : 102)
Query Neighborhood Hits	198	Target Neighborhood Hits	457	Shared Neighborhood Hits	124
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

ARHG7_HUMAN
NC score	0.291235 (rank : 82)	θ value	0.0193708 (rank : 83)
Query Neighborhood Hits	198	Target Neighborhood Hits	347	Shared Neighborhood Hits	127
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GRAP2_HUMAN
NC score	0.287503 (rank : 83)	θ value	0.163984 (rank : 118)
Query Neighborhood Hits	198	Target Neighborhood Hits	304	Shared Neighborhood Hits	135
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_HUMAN
NC score	0.280440 (rank : 84)	θ value	0.0330416 (rank : 92)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ARHG6_MOUSE
NC score	0.278218 (rank : 85)	θ value	0.47712 (rank : 139)
Query Neighborhood Hits	198	Target Neighborhood Hits	394	Shared Neighborhood Hits	126
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PXK_HUMAN
NC score	0.276081 (rank : 86)	θ value	0.000461057 (rank : 41)
Query Neighborhood Hits	198	Target Neighborhood Hits	216	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SNX16_HUMAN
NC score	0.275920 (rank : 87)	θ value	0.00298849 (rank : 58)
Query Neighborhood Hits	198	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	P57768, Q8N4U3	Gene names	SNX16
Domain Architecture
Description	Sorting nexin-16.

STAC_HUMAN
NC score	0.274419 (rank : 88)	θ value	2.36792 (rank : 171)
Query Neighborhood Hits	198	Target Neighborhood Hits	276	Shared Neighborhood Hits	120
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CT032_HUMAN
NC score	0.273681 (rank : 89)	θ value	0.279714 (rank : 130)
Query Neighborhood Hits	198	Target Neighborhood Hits	235	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

VAV_HUMAN
NC score	0.271831 (rank : 90)	θ value	0.00390308 (rank : 63)
Query Neighborhood Hits	198	Target Neighborhood Hits	452	Shared Neighborhood Hits	133
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.271307 (rank : 91)	θ value	0.00869519 (rank : 77)
Query Neighborhood Hits	198	Target Neighborhood Hits	430	Shared Neighborhood Hits	135
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

PXK_MOUSE
NC score	0.270466 (rank : 92)	θ value	0.000786445 (rank : 46)
Query Neighborhood Hits	198	Target Neighborhood Hits	320	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

ARHG6_HUMAN
NC score	0.270351 (rank : 93)	θ value	0.279714 (rank : 129)
Query Neighborhood Hits	198	Target Neighborhood Hits	376	Shared Neighborhood Hits	124
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SNX16_MOUSE
NC score	0.269298 (rank : 94)	θ value	0.0113563 (rank : 78)
Query Neighborhood Hits	198	Target Neighborhood Hits	82	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

NCK2_HUMAN
NC score	0.267953 (rank : 95)	θ value	1.06291 (rank : 157)
Query Neighborhood Hits	198	Target Neighborhood Hits	310	Shared Neighborhood Hits	133
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NPHP1_MOUSE
NC score	0.263391 (rank : 96)	θ value	1.06291 (rank : 158)
Query Neighborhood Hits	198	Target Neighborhood Hits	267	Shared Neighborhood Hits	116
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
NC score	0.257006 (rank : 97)	θ value	0.21417 (rank : 126)
Query Neighborhood Hits	198	Target Neighborhood Hits	466	Shared Neighborhood Hits	128
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

NEBU_HUMAN
NC score	0.256999 (rank : 98)	θ value	0.0563607 (rank : 103)
Query Neighborhood Hits	198	Target Neighborhood Hits	420	Shared Neighborhood Hits	118
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

STAC_MOUSE
NC score	0.256814 (rank : 99)	θ value	6.88961 (rank : 192)
Query Neighborhood Hits	198	Target Neighborhood Hits	268	Shared Neighborhood Hits	115
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SHLB1_MOUSE
NC score	0.256065 (rank : 100)	θ value	0.47712 (rank : 142)
Query Neighborhood Hits	198	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

NCK1_HUMAN
NC score	0.252795 (rank : 101)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	198	Target Neighborhood Hits	312	Shared Neighborhood Hits	131
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NPHP1_HUMAN
NC score	0.250647 (rank : 102)	θ value	0.365318 (rank : 134)
Query Neighborhood Hits	198	Target Neighborhood Hits	288	Shared Neighborhood Hits	111
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

BCAR1_HUMAN
NC score	0.250542 (rank : 103)	θ value	0.0736092 (rank : 108)
Query Neighborhood Hits	198	Target Neighborhood Hits	554	Shared Neighborhood Hits	123
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SHLB1_HUMAN
NC score	0.249191 (rank : 104)	θ value	0.47712 (rank : 141)
Query Neighborhood Hits	198	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

BCAR1_MOUSE
NC score	0.248389 (rank : 105)	θ value	0.365318 (rank : 133)
Query Neighborhood Hits	198	Target Neighborhood Hits	438	Shared Neighborhood Hits	121
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_MOUSE
NC score	0.247994 (rank : 106)	θ value	0.21417 (rank : 124)
Query Neighborhood Hits	198	Target Neighborhood Hits	225	Shared Neighborhood Hits	116
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

NCF1_MOUSE
NC score	0.245177 (rank : 107)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	198	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

OSTF1_MOUSE
NC score	0.244989 (rank : 108)	θ value	0.813845 (rank : 152)
Query Neighborhood Hits	198	Target Neighborhood Hits	467	Shared Neighborhood Hits	129
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

CASL_HUMAN
NC score	0.241165 (rank : 109)	θ value	1.38821 (rank : 161)
Query Neighborhood Hits	198	Target Neighborhood Hits	259	Shared Neighborhood Hits	113
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

NCF1_HUMAN
NC score	0.238178 (rank : 110)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	198	Target Neighborhood Hits	198	Shared Neighborhood Hits	116
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ITSN1_MOUSE
NC score	0.237746 (rank : 111)	θ value	0.000786445 (rank : 44)
Query Neighborhood Hits	198	Target Neighborhood Hits	1669	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SNX14_HUMAN
NC score	0.237150 (rank : 112)	θ value	0.21417 (rank : 127)
Query Neighborhood Hits	198	Target Neighborhood Hits	77	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

ITSN2_HUMAN
NC score	0.237051 (rank : 113)	θ value	0.00665767 (rank : 71)
Query Neighborhood Hits	198	Target Neighborhood Hits	1173	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SNX14_MOUSE
NC score	0.234414 (rank : 114)	θ value	0.163984 (rank : 120)
Query Neighborhood Hits	198	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

ITSN1_HUMAN
NC score	0.232296 (rank : 115)	θ value	0.000461057 (rank : 40)
Query Neighborhood Hits	198	Target Neighborhood Hits	1757	Shared Neighborhood Hits	144
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SNX27_HUMAN
NC score	0.230761 (rank : 116)	θ value	0.0193708 (rank : 86)
Query Neighborhood Hits	198	Target Neighborhood Hits	54	Shared Neighborhood Hits	30
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

SHLB2_MOUSE
NC score	0.225824 (rank : 117)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	198	Target Neighborhood Hits	88	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.224585 (rank : 118)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	198	Target Neighborhood Hits	86	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

VAV2_MOUSE
NC score	0.223610 (rank : 119)	θ value	0.47712 (rank : 143)
Query Neighborhood Hits	198	Target Neighborhood Hits	456	Shared Neighborhood Hits	128
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.221974 (rank : 120)	θ value	0.62314 (rank : 146)
Query Neighborhood Hits	198	Target Neighborhood Hits	453	Shared Neighborhood Hits	129
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ES8L3_MOUSE
NC score	0.221365 (rank : 121)	θ value	1.81305 (rank : 166)
Query Neighborhood Hits	198	Target Neighborhood Hits	168	Shared Neighborhood Hits	104
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

AHI1_MOUSE
NC score	0.221101 (rank : 122)	θ value	0.47712 (rank : 138)
Query Neighborhood Hits	198	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

DDEF1_MOUSE
NC score	0.219037 (rank : 123)	θ value	0.000602161 (rank : 42)
Query Neighborhood Hits	198	Target Neighborhood Hits	592	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SNX20_MOUSE
NC score	0.219011 (rank : 124)	θ value	0.163984 (rank : 121)
Query Neighborhood Hits	198	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2Y5, Q544B6	Gene names	Snx20
Domain Architecture	No domain graphic available
Description	Sorting nexin-20.

AHI1_HUMAN
NC score	0.218128 (rank : 125)	θ value	0.813845 (rank : 148)
Query Neighborhood Hits	198	Target Neighborhood Hits	537	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

EPS8_MOUSE
NC score	0.217558 (rank : 126)	θ value	0.00228821 (rank : 53)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_HUMAN
NC score	0.216596 (rank : 127)	θ value	0.00298849 (rank : 56)
Query Neighborhood Hits	198	Target Neighborhood Hits	151	Shared Neighborhood Hits	85
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

RIMB2_HUMAN
NC score	0.215516 (rank : 128)	θ value	1.06291 (rank : 159)
Query Neighborhood Hits	198	Target Neighborhood Hits	263	Shared Neighborhood Hits	95
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ITSN2_MOUSE
NC score	0.215311 (rank : 129)	θ value	0.0736092 (rank : 110)
Query Neighborhood Hits	198	Target Neighborhood Hits	1371	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV3_HUMAN
NC score	0.208887 (rank : 130)	θ value	0.365318 (rank : 137)
Query Neighborhood Hits	198	Target Neighborhood Hits	398	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

STAC3_MOUSE
NC score	0.205905 (rank : 131)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	198	Target Neighborhood Hits	232	Shared Neighborhood Hits	103
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ES8L3_HUMAN
NC score	0.204783 (rank : 132)	θ value	0.47712 (rank : 140)
Query Neighborhood Hits	198	Target Neighborhood Hits	206	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

STAC3_HUMAN
NC score	0.204611 (rank : 133)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	198	Target Neighborhood Hits	228	Shared Neighborhood Hits	103
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CIP4_HUMAN
NC score	0.201569 (rank : 134)	θ value	0.00390308 (rank : 59)
Query Neighborhood Hits	198	Target Neighborhood Hits	374	Shared Neighborhood Hits	57
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

VAV3_MOUSE
NC score	0.200702 (rank : 135)	θ value	0.813845 (rank : 155)
Query Neighborhood Hits	198	Target Neighborhood Hits	404	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

DDEF2_HUMAN
NC score	0.199929 (rank : 136)	θ value	0.00102713 (rank : 49)
Query Neighborhood Hits	198	Target Neighborhood Hits	599	Shared Neighborhood Hits	114
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.197678 (rank : 137)	θ value	0.00134147 (rank : 51)
Query Neighborhood Hits	198	Target Neighborhood Hits	625	Shared Neighborhood Hits	111
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ES8L2_HUMAN
NC score	0.197388 (rank : 138)	θ value	0.163984 (rank : 117)
Query Neighborhood Hits	198	Target Neighborhood Hits	193	Shared Neighborhood Hits	99
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

RHG26_HUMAN
NC score	0.195548 (rank : 139)	θ value	0.0736092 (rank : 114)
Query Neighborhood Hits	198	Target Neighborhood Hits	281	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ES8L2_MOUSE
NC score	0.194611 (rank : 140)	θ value	0.0961366 (rank : 115)
Query Neighborhood Hits	198	Target Neighborhood Hits	169	Shared Neighborhood Hits	97
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

RIMB2_MOUSE
NC score	0.192611 (rank : 141)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	198	Target Neighborhood Hits	246	Shared Neighborhood Hits	85
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_HUMAN
NC score	0.185297 (rank : 142)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	198	Target Neighborhood Hits	226	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

PLCG1_MOUSE
NC score	0.179205 (rank : 143)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	198	Target Neighborhood Hits	314	Shared Neighborhood Hits	111
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ARHG4_HUMAN
NC score	0.176456 (rank : 144)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	198	Target Neighborhood Hits	242	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ES8L1_MOUSE
NC score	0.171150 (rank : 145)	θ value	0.813845 (rank : 150)
Query Neighborhood Hits	198	Target Neighborhood Hits	143	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_HUMAN
NC score	0.170621 (rank : 146)	θ value	1.06291 (rank : 156)
Query Neighborhood Hits	198	Target Neighborhood Hits	162	Shared Neighborhood Hits	77
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

MYO1F_HUMAN
NC score	0.170549 (rank : 147)	θ value	0.00228821 (rank : 54)
Query Neighborhood Hits	198	Target Neighborhood Hits	275	Shared Neighborhood Hits	129
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.169522 (rank : 148)	θ value	0.00298849 (rank : 57)
Query Neighborhood Hits	198	Target Neighborhood Hits	262	Shared Neighborhood Hits	129
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SNX13_HUMAN
NC score	0.169006 (rank : 149)	θ value	0.0148317 (rank : 82)
Query Neighborhood Hits	198	Target Neighborhood Hits	84	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

ARHG5_HUMAN
NC score	0.166961 (rank : 150)	θ value	0.00509761 (rank : 67)
Query Neighborhood Hits	198	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PLCG2_HUMAN
NC score	0.165736 (rank : 151)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	198	Target Neighborhood Hits	280	Shared Neighborhood Hits	110
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.165115 (rank : 152)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	198	Target Neighborhood Hits	293	Shared Neighborhood Hits	106
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SNX13_MOUSE
NC score	0.165028 (rank : 153)	θ value	0.0330416 (rank : 95)
Query Neighborhood Hits	198	Target Neighborhood Hits	86	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

ARHG9_MOUSE
NC score	0.160277 (rank : 154)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	198	Target Neighborhood Hits	234	Shared Neighborhood Hits	104
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.160072 (rank : 155)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	198	Target Neighborhood Hits	235	Shared Neighborhood Hits	104
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

RUSC1_MOUSE
NC score	0.157263 (rank : 156)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	198	Target Neighborhood Hits	206	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SPTA1_MOUSE
NC score	0.152905 (rank : 157)	θ value	0.0193708 (rank : 87)
Query Neighborhood Hits	198	Target Neighborhood Hits	675	Shared Neighborhood Hits	122
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

MYO1E_HUMAN
NC score	0.152147 (rank : 158)	θ value	0.0736092 (rank : 113)
Query Neighborhood Hits	198	Target Neighborhood Hits	293	Shared Neighborhood Hits	125
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SPTA2_HUMAN
NC score	0.147585 (rank : 159)	θ value	0.00869519 (rank : 75)
Query Neighborhood Hits	198	Target Neighborhood Hits	888	Shared Neighborhood Hits	127
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SNX15_HUMAN
NC score	0.146694 (rank : 160)	θ value	0.0563607 (rank : 105)
Query Neighborhood Hits	198	Target Neighborhood Hits	50	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NRS6, Q9NRS5	Gene names	SNX15
Domain Architecture
Description	Sorting nexin-15.

SPTA1_HUMAN
NC score	0.146557 (rank : 161)	θ value	0.0113563 (rank : 79)
Query Neighborhood Hits	198	Target Neighborhood Hits	748	Shared Neighborhood Hits	121
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPN90_HUMAN
NC score	0.145857 (rank : 162)	θ value	2.36792 (rank : 170)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SNX15_MOUSE
NC score	0.144712 (rank : 163)	θ value	0.0563607 (rank : 106)
Query Neighborhood Hits	198	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WE1	Gene names	Snx15
Domain Architecture	No domain graphic available
Description	Sorting nexin-15.

SNX19_HUMAN
NC score	0.137932 (rank : 164)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	198	Target Neighborhood Hits	123	Shared Neighborhood Hits	30
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

P85A_MOUSE
NC score	0.137543 (rank : 165)	θ value	0.0148317 (rank : 81)
Query Neighborhood Hits	198	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

JIP2_MOUSE
NC score	0.136292 (rank : 166)	θ value	0.0736092 (rank : 112)
Query Neighborhood Hits	198	Target Neighborhood Hits	144	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

RHG04_HUMAN
NC score	0.136004 (rank : 167)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	198	Target Neighborhood Hits	307	Shared Neighborhood Hits	112
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ARHG4_MOUSE
NC score	0.134663 (rank : 168)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	198	Target Neighborhood Hits	185	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

IASPP_MOUSE
NC score	0.133839 (rank : 169)	θ value	0.279714 (rank : 131)
Query Neighborhood Hits	198	Target Neighborhood Hits	1024	Shared Neighborhood Hits	116
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_HUMAN
NC score	0.132754 (rank : 170)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	198	Target Neighborhood Hits	688	Shared Neighborhood Hits	112
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JIP2_HUMAN
NC score	0.131622 (rank : 171)	θ value	0.0736092 (rank : 111)
Query Neighborhood Hits	198	Target Neighborhood Hits	288	Shared Neighborhood Hits	53
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

P85A_HUMAN
NC score	0.131435 (rank : 172)	θ value	0.0431538 (rank : 98)
Query Neighborhood Hits	198	Target Neighborhood Hits	479	Shared Neighborhood Hits	77
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX17_MOUSE
NC score	0.130495 (rank : 173)	θ value	1.38821 (rank : 164)
Query Neighborhood Hits	198	Target Neighborhood Hits	34	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BVL3, Q8R0N8	Gene names	Snx17
Domain Architecture	No domain graphic available
Description	Sorting nexin-17.

NOXO1_MOUSE
NC score	0.130356 (rank : 174)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	198	Target Neighborhood Hits	114	Shared Neighborhood Hits	78
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SPN90_MOUSE
NC score	0.129456 (rank : 175)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	198	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRGP2_MOUSE
NC score	0.119348 (rank : 176)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	198	Target Neighborhood Hits	324	Shared Neighborhood Hits	104
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.117605 (rank : 177)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	198	Target Neighborhood Hits	331	Shared Neighborhood Hits	103
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ASPP1_MOUSE
NC score	0.116473 (rank : 178)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	198	Target Neighborhood Hits	1244	Shared Neighborhood Hits	123
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RIMB1_HUMAN
NC score	0.116467 (rank : 179)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	198	Target Neighborhood Hits	1479	Shared Neighborhood Hits	107
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ASPP1_HUMAN
NC score	0.116450 (rank : 180)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	198	Target Neighborhood Hits	956	Shared Neighborhood Hits	118
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SNX17_HUMAN
NC score	0.112067 (rank : 181)	θ value	6.88961 (rank : 190)
Query Neighborhood Hits	198	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	Q15036, Q53HN7, Q6IAS3	Gene names	SNX17, KIAA0064
Domain Architecture
Description	Sorting nexin-17.

ANM2_HUMAN
NC score	0.111303 (rank : 182)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	198	Target Neighborhood Hits	175	Shared Neighborhood Hits	101
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SRGP1_HUMAN
NC score	0.110913 (rank : 183)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	198	Target Neighborhood Hits	390	Shared Neighborhood Hits	102
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STS2_HUMAN
NC score	0.109868 (rank : 184)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	198	Target Neighborhood Hits	108	Shared Neighborhood Hits	65
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ANM2_MOUSE
NC score	0.106072 (rank : 185)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	198	Target Neighborhood Hits	175	Shared Neighborhood Hits	101
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

FNBP2_HUMAN
NC score	0.105590 (rank : 186)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	198	Target Neighborhood Hits	432	Shared Neighborhood Hits	104
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RIMB1_MOUSE
NC score	0.104173 (rank : 187)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	198	Target Neighborhood Hits	1376	Shared Neighborhood Hits	110
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

P85B_HUMAN
NC score	0.104068 (rank : 188)	θ value	0.813845 (rank : 153)
Query Neighborhood Hits	198	Target Neighborhood Hits	543	Shared Neighborhood Hits	57
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DOCK1_HUMAN
NC score	0.103644 (rank : 189)	θ value	0.813845 (rank : 149)
Query Neighborhood Hits	198	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

BAIP2_MOUSE
NC score	0.103380 (rank : 190)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	198	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAIP2_HUMAN
NC score	0.101604 (rank : 191)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	198	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

NGEF_MOUSE
NC score	0.101229 (rank : 192)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	198	Target Neighborhood Hits	228	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.100303 (rank : 193)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	198	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SNX5_HUMAN
NC score	0.098597 (rank : 194)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	198	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5X3, Q52LC4, Q9BWP0	Gene names	SNX5
Domain Architecture
Description	Sorting nexin-5.

SNX5_MOUSE
NC score	0.096474 (rank : 195)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	198	Target Neighborhood Hits	81	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D8U8, Q543N9	Gene names	Snx5
Domain Architecture
Description	Sorting nexin-5.

PPIP2_HUMAN
NC score	0.094506 (rank : 196)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	198	Target Neighborhood Hits	254	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

BI2L1_HUMAN
NC score	0.093025 (rank : 197)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	198	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

P85B_MOUSE
NC score	0.091224 (rank : 198)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	198	Target Neighborhood Hits	519	Shared Neighborhood Hits	52
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ASPP2_HUMAN
NC score	0.091125 (rank : 199)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	198	Target Neighborhood Hits	1156	Shared Neighborhood Hits	101
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BI2L1_MOUSE
NC score	0.089013 (rank : 200)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	198	Target Neighborhood Hits	197	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

TCGAP_MOUSE
NC score	0.088829 (rank : 201)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	198	Target Neighborhood Hits	409	Shared Neighborhood Hits	93
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NOXO1_HUMAN
NC score	0.087251 (rank : 202)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	198	Target Neighborhood Hits	100	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SNX24_MOUSE
NC score	0.087211 (rank : 203)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	198	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CRB0	Gene names	Snx24
Domain Architecture	No domain graphic available
Description	Sorting nexin-24.

SNX21_HUMAN
NC score	0.087031 (rank : 204)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	198	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q969T3, Q5JZH6, Q9BR16	Gene names	SNX21, C20orf161, SNXL
Domain Architecture
Description	Sorting nexin-21 (Sorting nexin L) (SNX-L).

SNX24_HUMAN
NC score	0.086943 (rank : 205)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	198	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y343, Q6UY33	Gene names	SNX24
Domain Architecture
Description	Sorting nexin-24.

ARHGG_MOUSE
NC score	0.086393 (rank : 206)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	198	Target Neighborhood Hits	152	Shared Neighborhood Hits	46
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SNX6_HUMAN
NC score	0.085599 (rank : 207)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	198	Target Neighborhood Hits	52	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UNH7, Q9Y449	Gene names	SNX6
Domain Architecture
Description	Sorting nexin-6 (TRAF4-associated factor 2).

SNX6_MOUSE
NC score	0.085401 (rank : 208)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	198	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	Q6P8X1	Gene names	Snx6
Domain Architecture	No domain graphic available
Description	Sorting nexin-6.

PPIP2_MOUSE
NC score	0.085162 (rank : 209)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	198	Target Neighborhood Hits	308	Shared Neighborhood Hits	18
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

SHAN2_MOUSE
NC score	0.085057 (rank : 210)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	198	Target Neighborhood Hits	446	Shared Neighborhood Hits	80
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SNX25_HUMAN
NC score	0.084758 (rank : 211)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	198	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3E2	Gene names	SNX25
Domain Architecture
Description	Sorting nexin-25.

M3KL4_HUMAN
NC score	0.082913 (rank : 212)	θ value	0.163984 (rank : 119)
Query Neighborhood Hits	198	Target Neighborhood Hits	1087	Shared Neighborhood Hits	124
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

TCGAP_HUMAN
NC score	0.082852 (rank : 213)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	198	Target Neighborhood Hits	872	Shared Neighborhood Hits	96
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STS1_MOUSE
NC score	0.082436 (rank : 214)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	198	Target Neighborhood Hits	104	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

AMPH_HUMAN
NC score	0.081876 (rank : 215)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	198	Target Neighborhood Hits	455	Shared Neighborhood Hits	65
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

STS1_HUMAN
NC score	0.081572 (rank : 216)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	198	Target Neighborhood Hits	106	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BIN1_MOUSE
NC score	0.079690 (rank : 217)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	198	Target Neighborhood Hits	283	Shared Neighborhood Hits	62
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BIN1_HUMAN
NC score	0.078946 (rank : 218)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	198	Target Neighborhood Hits	335	Shared Neighborhood Hits	57
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SLY_MOUSE
NC score	0.078595 (rank : 219)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	198	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

JIP1_HUMAN
NC score	0.075236 (rank : 220)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	198	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
NC score	0.074394 (rank : 221)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	198	Target Neighborhood Hits	259	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SRC_HUMAN
NC score	0.072824 (rank : 222)	θ value	0.163984 (rank : 122)
Query Neighborhood Hits	198	Target Neighborhood Hits	1058	Shared Neighborhood Hits	131
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

AMPH_MOUSE
NC score	0.071685 (rank : 223)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	198	Target Neighborhood Hits	291	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

P55G_MOUSE
NC score	0.070974 (rank : 224)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	198	Target Neighborhood Hits	401	Shared Neighborhood Hits	38
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ARHGG_HUMAN
NC score	0.070894 (rank : 225)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	198	Target Neighborhood Hits	129	Shared Neighborhood Hits	34
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

P55G_HUMAN
NC score	0.070486 (rank : 226)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	198	Target Neighborhood Hits	451	Shared Neighborhood Hits	38
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

FYN_MOUSE
NC score	0.069883 (rank : 227)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	198	Target Neighborhood Hits	1073	Shared Neighborhood Hits	130
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GPS2_HUMAN
NC score	0.068943 (rank : 228)	θ value	0.21417 (rank : 125)
Query Neighborhood Hits	198	Target Neighborhood Hits	459	Shared Neighborhood Hits	13
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

FYN_HUMAN
NC score	0.068679 (rank : 229)	θ value	6.88961 (rank : 188)
Query Neighborhood Hits	198	Target Neighborhood Hits	1078	Shared Neighborhood Hits	130
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

PKHG1_HUMAN
NC score	0.067528 (rank : 230)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	198	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FGR_HUMAN
NC score	0.067381 (rank : 231)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	198	Target Neighborhood Hits	1067	Shared Neighborhood Hits	127
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

P3C2B_HUMAN
NC score	0.066900 (rank : 232)	θ value	0.00020696 (rank : 38)
Query Neighborhood Hits	198	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

ARHG3_HUMAN
NC score	0.066458 (rank : 233)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	198	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.066400 (rank : 234)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	198	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

FGR_MOUSE
NC score	0.066368 (rank : 235)	θ value	5.27518 (rank : 186)
Query Neighborhood Hits	198	Target Neighborhood Hits	1069	Shared Neighborhood Hits	130
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLY_HUMAN
NC score	0.066305 (rank : 236)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	198	Target Neighborhood Hits	81	Shared Neighborhood Hits	46
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

M3K11_HUMAN
NC score	0.065068 (rank : 237)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	198	Target Neighborhood Hits	1136	Shared Neighborhood Hits	113
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ARHG8_MOUSE
NC score	0.064126 (rank : 238)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	198	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

M3K10_HUMAN
NC score	0.063848 (rank : 239)	θ value	1.81305 (rank : 167)
Query Neighborhood Hits	198	Target Neighborhood Hits	1071	Shared Neighborhood Hits	113
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

SHAN1_HUMAN
NC score	0.063799 (rank : 240)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	198	Target Neighborhood Hits	1041	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

MCF2L_MOUSE
NC score	0.063031 (rank : 241)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	198	Target Neighborhood Hits	255	Shared Neighborhood Hits	31
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TIAM1_MOUSE
NC score	0.062782 (rank : 242)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	198	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

YES_MOUSE
NC score	0.062741 (rank : 243)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	198	Target Neighborhood Hits	1052	Shared Neighborhood Hits	125
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M3K9_HUMAN
NC score	0.061566 (rank : 244)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	198	Target Neighborhood Hits	1123	Shared Neighborhood Hits	119
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

YES_HUMAN
NC score	0.061480 (rank : 245)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	198	Target Neighborhood Hits	1059	Shared Neighborhood Hits	125
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG8_HUMAN
NC score	0.061065 (rank : 246)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	198	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

PREX1_HUMAN
NC score	0.060898 (rank : 247)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	198	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TIAM1_HUMAN
NC score	0.060317 (rank : 248)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	198	Target Neighborhood Hits	225	Shared Neighborhood Hits	18
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SNX22_HUMAN
NC score	0.059486 (rank : 249)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	198	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	Q96L94, Q9H844	Gene names	SNX22
Domain Architecture
Description	Sorting nexin-22.

BTK_HUMAN
NC score	0.059169 (rank : 250)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	198	Target Neighborhood Hits	1026	Shared Neighborhood Hits	128
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.056001 (rank : 251)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	198	Target Neighborhood Hits	1017	Shared Neighborhood Hits	124
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

RASA1_HUMAN
NC score	0.055990 (rank : 252)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	198	Target Neighborhood Hits	258	Shared Neighborhood Hits	43
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RUSC2_HUMAN
NC score	0.055651 (rank : 253)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	198	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SLAP2_MOUSE
NC score	0.055513 (rank : 254)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	198	Target Neighborhood Hits	136	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ARHGA_MOUSE
NC score	0.055182 (rank : 255)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	198	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SLAP2_HUMAN
NC score	0.054993 (rank : 256)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	198	Target Neighborhood Hits	139	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

ECT2_MOUSE
NC score	0.054903 (rank : 257)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	198	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

HCK_HUMAN
NC score	0.054412 (rank : 258)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	198	Target Neighborhood Hits	1035	Shared Neighborhood Hits	125
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
NC score	0.054258 (rank : 259)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	198	Target Neighborhood Hits	1029	Shared Neighborhood Hits	124
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

EM55_HUMAN
NC score	0.053436 (rank : 260)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	198	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

ARHGA_HUMAN
NC score	0.052908 (rank : 261)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	198	Target Neighborhood Hits	187	Shared Neighborhood Hits	18
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_HUMAN
NC score	0.052890 (rank : 262)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	198	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SRC_MOUSE
NC score	0.052800 (rank : 263)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	198	Target Neighborhood Hits	1033	Shared Neighborhood Hits	121
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

MCF2_HUMAN
NC score	0.052256 (rank : 264)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	198	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

TXK_MOUSE
NC score	0.051950 (rank : 265)	θ value	0.163984 (rank : 123)
Query Neighborhood Hits	198	Target Neighborhood Hits	980	Shared Neighborhood Hits	104
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

EM55_MOUSE
NC score	0.051452 (rank : 266)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	198	Target Neighborhood Hits	221	Shared Neighborhood Hits	64
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

RUSC2_MOUSE
NC score	0.050392 (rank : 267)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	198	Target Neighborhood Hits	305	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SGK3_HUMAN
NC score	0.049439 (rank : 268)	θ value	5.44631e-05 (rank : 30)
Query Neighborhood Hits	198	Target Neighborhood Hits	877	Shared Neighborhood Hits	49
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
NC score	0.048732 (rank : 269)	θ value	0.000158464 (rank : 36)
Query Neighborhood Hits	198	Target Neighborhood Hits	882	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

P3C2A_HUMAN
NC score	0.043301 (rank : 270)	θ value	1.38821 (rank : 163)
Query Neighborhood Hits	198	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

TXK_HUMAN
NC score	0.043125 (rank : 271)	θ value	1.06291 (rank : 160)
Query Neighborhood Hits	198	Target Neighborhood Hits	971	Shared Neighborhood Hits	92
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

P3C2A_MOUSE
NC score	0.042412 (rank : 272)	θ value	1.81305 (rank : 168)
Query Neighborhood Hits	198	Target Neighborhood Hits	181	Shared Neighborhood Hits	14
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

MISS_MOUSE
NC score	0.030512 (rank : 273)	θ value	0.813845 (rank : 151)
Query Neighborhood Hits	198	Target Neighborhood Hits	444	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MYH13_HUMAN
NC score	0.029417 (rank : 274)	θ value	0.279714 (rank : 132)
Query Neighborhood Hits	198	Target Neighborhood Hits	1504	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

SRMS_MOUSE
NC score	0.028943 (rank : 275)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	198	Target Neighborhood Hits	964	Shared Neighborhood Hits	78
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

MAVS_MOUSE
NC score	0.027794 (rank : 276)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	198	Target Neighborhood Hits	170	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

CABIN_HUMAN
NC score	0.026083 (rank : 277)	θ value	4.03905 (rank : 178)
Query Neighborhood Hits	198	Target Neighborhood Hits	490	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

SC24C_HUMAN
NC score	0.021168 (rank : 278)	θ value	0.813845 (rank : 154)
Query Neighborhood Hits	198	Target Neighborhood Hits	662	Shared Neighborhood Hits	14
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

AMBN_HUMAN
NC score	0.016898 (rank : 279)	θ value	5.27518 (rank : 184)
Query Neighborhood Hits	198	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NP70, Q9H2X1, Q9H4L1	Gene names	AMBN
Domain Architecture
Description	Ameloblastin precursor.

CSKI1_MOUSE
NC score	0.015215 (rank : 280)	θ value	5.27518 (rank : 185)
Query Neighborhood Hits	198	Target Neighborhood Hits	1031	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SSBP4_HUMAN
NC score	0.011448 (rank : 281)	θ value	6.88961 (rank : 191)
Query Neighborhood Hits	198	Target Neighborhood Hits	753	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

ECEL1_MOUSE
NC score	0.010163 (rank : 282)	θ value	2.36792 (rank : 169)
Query Neighborhood Hits	198	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JMI0	Gene names	Ecel1, Dine, Xce
Domain Architecture
Description	Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) (Damage-induced neuronal endopeptidase).

GRIP1_MOUSE
NC score	0.009885 (rank : 283)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	198	Target Neighborhood Hits	241	Shared Neighborhood Hits	4
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

NRX2B_HUMAN
NC score	0.009114 (rank : 284)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	198	Target Neighborhood Hits	481	Shared Neighborhood Hits	13
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

GPR98_HUMAN
NC score	0.008781 (rank : 285)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	198	Target Neighborhood Hits	202	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

K1802_HUMAN
NC score	0.007500 (rank : 286)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	198	Target Neighborhood Hits	1378	Shared Neighborhood Hits	26
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

EGFL7_HUMAN
NC score	0.007412 (rank : 287)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	198	Target Neighborhood Hits	325	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

NRX2A_HUMAN
NC score	0.004957 (rank : 288)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	198	Target Neighborhood Hits	614	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

PASK_HUMAN
NC score	0.003291 (rank : 289)	θ value	5.27518 (rank : 187)
Query Neighborhood Hits	198	Target Neighborhood Hits	857	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

ZBT7A_HUMAN
NC score	-0.000564 (rank : 290)	θ value	0.62314 (rank : 147)
Query Neighborhood Hits	198	Target Neighborhood Hits	823	Shared Neighborhood Hits	6
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

GLI2_HUMAN
NC score	-0.000724 (rank : 291)	θ value	1.38821 (rank : 162)
Query Neighborhood Hits	198	Target Neighborhood Hits	971	Shared Neighborhood Hits	11
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

NOTC2_MOUSE
NC score	-0.002317 (rank : 292)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	198	Target Neighborhood Hits	1069	Shared Neighborhood Hits	14
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

GLIS3_MOUSE
NC score	-0.002939 (rank : 293)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	198	Target Neighborhood Hits	861	Shared Neighborhood Hits	9
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).