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Network neighborhood for query Sequence : ES8L3_HUMAN

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ES8L3_HUMAN
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ES8L3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	206
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	0 (rank : 2)	NC score	0.969948 (rank : 2)
Query Neighborhood Hits	206	Target Neighborhood Hits	168	Shared Neighborhood Hits	126
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L2_MOUSE
θ value	4.52582e-68 (rank : 3)	NC score	0.890967 (rank : 3)
Query Neighborhood Hits	206	Target Neighborhood Hits	169	Shared Neighborhood Hits	109
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_HUMAN
θ value	3.03575e-64 (rank : 4)	NC score	0.883097 (rank : 5)
Query Neighborhood Hits	206	Target Neighborhood Hits	193	Shared Neighborhood Hits	113
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_HUMAN
θ value	8.26713e-62 (rank : 5)	NC score	0.866862 (rank : 8)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	1.41016e-61 (rank : 6)	NC score	0.871577 (rank : 7)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	105
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_MOUSE
θ value	1.41016e-61 (rank : 7)	NC score	0.877954 (rank : 6)
Query Neighborhood Hits	206	Target Neighborhood Hits	143	Shared Neighborhood Hits	88
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_HUMAN
θ value	4.53632e-60 (rank : 8)	NC score	0.884414 (rank : 4)
Query Neighborhood Hits	206	Target Neighborhood Hits	162	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

BLK_MOUSE
θ value	1.99992e-07 (rank : 9)	NC score	0.194890 (rank : 94)
Query Neighborhood Hits	206	Target Neighborhood Hits	992	Shared Neighborhood Hits	111
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

NCK2_HUMAN
θ value	7.59969e-07 (rank : 10)	NC score	0.465238 (rank : 9)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	132
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

BLK_HUMAN
θ value	3.77169e-06 (rank : 11)	NC score	0.191594 (rank : 102)
Query Neighborhood Hits	206	Target Neighborhood Hits	994	Shared Neighborhood Hits	115
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PPIP1_HUMAN
θ value	1.09739e-05 (rank : 12)	NC score	0.363794 (rank : 17)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	128
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

NCK1_HUMAN
θ value	1.43324e-05 (rank : 13)	NC score	0.446714 (rank : 10)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	132
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

BTK_MOUSE
θ value	2.44474e-05 (rank : 14)	NC score	0.196043 (rank : 92)
Query Neighborhood Hits	206	Target Neighborhood Hits	1017	Shared Neighborhood Hits	128
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTK_HUMAN
θ value	3.19293e-05 (rank : 15)	NC score	0.196107 (rank : 91)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	131
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FGR_MOUSE
θ value	9.29e-05 (rank : 16)	NC score	0.192822 (rank : 98)
Query Neighborhood Hits	206	Target Neighborhood Hits	1069	Shared Neighborhood Hits	133
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

DNMBP_MOUSE
θ value	0.000121331 (rank : 17)	NC score	0.304012 (rank : 34)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	135
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRC_HUMAN
θ value	0.000158464 (rank : 18)	NC score	0.189919 (rank : 106)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	136
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

YES_MOUSE
θ value	0.000158464 (rank : 19)	NC score	0.192879 (rank : 97)
Query Neighborhood Hits	206	Target Neighborhood Hits	1052	Shared Neighborhood Hits	131
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

DNMBP_HUMAN
θ value	0.00020696 (rank : 20)	NC score	0.319026 (rank : 32)
Query Neighborhood Hits	206	Target Neighborhood Hits	413	Shared Neighborhood Hits	135
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HCK_HUMAN
θ value	0.00020696 (rank : 21)	NC score	0.190711 (rank : 103)
Query Neighborhood Hits	206	Target Neighborhood Hits	1035	Shared Neighborhood Hits	129
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FYN_HUMAN
θ value	0.000270298 (rank : 22)	NC score	0.189724 (rank : 107)
Query Neighborhood Hits	206	Target Neighborhood Hits	1078	Shared Neighborhood Hits	135
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.000270298 (rank : 23)	NC score	0.192605 (rank : 99)
Query Neighborhood Hits	206	Target Neighborhood Hits	1073	Shared Neighborhood Hits	135
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_MOUSE
θ value	0.000270298 (rank : 24)	NC score	0.183999 (rank : 115)
Query Neighborhood Hits	206	Target Neighborhood Hits	1033	Shared Neighborhood Hits	125
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

YES_HUMAN
θ value	0.000270298 (rank : 25)	NC score	0.192143 (rank : 100)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	129
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_HUMAN
θ value	0.00035302 (rank : 26)	NC score	0.185685 (rank : 113)
Query Neighborhood Hits	206	Target Neighborhood Hits	1067	Shared Neighborhood Hits	129
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ITK_HUMAN
θ value	0.00035302 (rank : 27)	NC score	0.175572 (rank : 121)
Query Neighborhood Hits	206	Target Neighborhood Hits	1016	Shared Neighborhood Hits	116
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	0.00035302 (rank : 28)	NC score	0.166993 (rank : 140)
Query Neighborhood Hits	206	Target Neighborhood Hits	985	Shared Neighborhood Hits	105
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LYN_MOUSE
θ value	0.00035302 (rank : 29)	NC score	0.173460 (rank : 125)
Query Neighborhood Hits	206	Target Neighborhood Hits	1023	Shared Neighborhood Hits	119
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ITSN2_MOUSE
θ value	0.000602161 (rank : 30)	NC score	0.217412 (rank : 71)
Query Neighborhood Hits	206	Target Neighborhood Hits	1371	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LYN_HUMAN
θ value	0.000602161 (rank : 31)	NC score	0.172875 (rank : 126)
Query Neighborhood Hits	206	Target Neighborhood Hits	1022	Shared Neighborhood Hits	120
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TXK_HUMAN
θ value	0.000602161 (rank : 32)	NC score	0.169069 (rank : 137)
Query Neighborhood Hits	206	Target Neighborhood Hits	971	Shared Neighborhood Hits	106
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ITSN2_HUMAN
θ value	0.000786445 (rank : 33)	NC score	0.230032 (rank : 65)
Query Neighborhood Hits	206	Target Neighborhood Hits	1173	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

M3K10_HUMAN
θ value	0.000786445 (rank : 34)	NC score	0.122550 (rank : 178)
Query Neighborhood Hits	206	Target Neighborhood Hits	1071	Shared Neighborhood Hits	120
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ITSN1_MOUSE
θ value	0.00102713 (rank : 35)	NC score	0.219572 (rank : 68)
Query Neighborhood Hits	206	Target Neighborhood Hits	1669	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TEC_MOUSE
θ value	0.00102713 (rank : 36)	NC score	0.172810 (rank : 127)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	117
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CRKL_MOUSE
θ value	0.00134147 (rank : 37)	NC score	0.383296 (rank : 13)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

HCK_MOUSE
θ value	0.00134147 (rank : 38)	NC score	0.189331 (rank : 108)
Query Neighborhood Hits	206	Target Neighborhood Hits	1029	Shared Neighborhood Hits	129
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

OSTF1_HUMAN
θ value	0.00134147 (rank : 39)	NC score	0.246035 (rank : 52)
Query Neighborhood Hits	206	Target Neighborhood Hits	466	Shared Neighborhood Hits	122
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SPTA1_MOUSE
θ value	0.00134147 (rank : 40)	NC score	0.191814 (rank : 101)
Query Neighborhood Hits	206	Target Neighborhood Hits	675	Shared Neighborhood Hits	122
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TEC_HUMAN
θ value	0.00134147 (rank : 41)	NC score	0.173598 (rank : 124)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	119
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

STAM2_MOUSE
θ value	0.00228821 (rank : 42)	NC score	0.350667 (rank : 22)
Query Neighborhood Hits	206	Target Neighborhood Hits	285	Shared Neighborhood Hits	125
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TXK_MOUSE
θ value	0.00228821 (rank : 43)	NC score	0.172447 (rank : 129)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	112
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CRKL_HUMAN
θ value	0.00298849 (rank : 44)	NC score	0.382174 (rank : 14)
Query Neighborhood Hits	206	Target Neighborhood Hits	313	Shared Neighborhood Hits	132
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NPHP1_MOUSE
θ value	0.00298849 (rank : 45)	NC score	0.362725 (rank : 18)
Query Neighborhood Hits	206	Target Neighborhood Hits	267	Shared Neighborhood Hits	121
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_MOUSE
θ value	0.00298849 (rank : 46)	NC score	0.233574 (rank : 63)
Query Neighborhood Hits	206	Target Neighborhood Hits	467	Shared Neighborhood Hits	122
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SPTA1_HUMAN
θ value	0.00390308 (rank : 47)	NC score	0.167809 (rank : 139)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	123
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	0.00509761 (rank : 48)	NC score	0.170221 (rank : 131)
Query Neighborhood Hits	206	Target Neighborhood Hits	888	Shared Neighborhood Hits	128
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAM2_HUMAN
θ value	0.00509761 (rank : 49)	NC score	0.339469 (rank : 24)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	125
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

VINEX_HUMAN
θ value	0.00509761 (rank : 50)	NC score	0.320067 (rank : 31)
Query Neighborhood Hits	206	Target Neighborhood Hits	270	Shared Neighborhood Hits	122
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCF2_HUMAN
θ value	0.0148317 (rank : 51)	NC score	0.329080 (rank : 28)
Query Neighborhood Hits	206	Target Neighborhood Hits	229	Shared Neighborhood Hits	109
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

STAC_HUMAN
θ value	0.0193708 (rank : 52)	NC score	0.271630 (rank : 39)
Query Neighborhood Hits	206	Target Neighborhood Hits	276	Shared Neighborhood Hits	120
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VINEX_MOUSE
θ value	0.0193708 (rank : 53)	NC score	0.338230 (rank : 25)
Query Neighborhood Hits	206	Target Neighborhood Hits	286	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ABL1_HUMAN
θ value	0.0252991 (rank : 54)	NC score	0.151404 (rank : 146)
Query Neighborhood Hits	206	Target Neighborhood Hits	1220	Shared Neighborhood Hits	114
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	0.0252991 (rank : 55)	NC score	0.151359 (rank : 147)
Query Neighborhood Hits	206	Target Neighborhood Hits	1178	Shared Neighborhood Hits	111
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	0.0252991 (rank : 56)	NC score	0.154914 (rank : 145)
Query Neighborhood Hits	206	Target Neighborhood Hits	1045	Shared Neighborhood Hits	108
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

MYO1E_HUMAN
θ value	0.0252991 (rank : 57)	NC score	0.114127 (rank : 190)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	121
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SRMS_MOUSE
θ value	0.0252991 (rank : 58)	NC score	0.145068 (rank : 154)
Query Neighborhood Hits	206	Target Neighborhood Hits	964	Shared Neighborhood Hits	86
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

VAV3_HUMAN
θ value	0.0252991 (rank : 59)	NC score	0.226934 (rank : 66)
Query Neighborhood Hits	206	Target Neighborhood Hits	398	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	0.0252991 (rank : 60)	NC score	0.218055 (rank : 69)
Query Neighborhood Hits	206	Target Neighborhood Hits	404	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

M3KL4_HUMAN
θ value	0.0330416 (rank : 61)	NC score	0.136748 (rank : 164)
Query Neighborhood Hits	206	Target Neighborhood Hits	1087	Shared Neighborhood Hits	129
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

STAM1_HUMAN
θ value	0.0330416 (rank : 62)	NC score	0.323308 (rank : 30)
Query Neighborhood Hits	206	Target Neighborhood Hits	271	Shared Neighborhood Hits	127
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP_HUMAN
θ value	0.0431538 (rank : 63)	NC score	0.370816 (rank : 15)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	134
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ITSN1_HUMAN
θ value	0.0431538 (rank : 64)	NC score	0.209985 (rank : 76)
Query Neighborhood Hits	206	Target Neighborhood Hits	1757	Shared Neighborhood Hits	145
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

STAM1_MOUSE
θ value	0.0431538 (rank : 65)	NC score	0.330389 (rank : 27)
Query Neighborhood Hits	206	Target Neighborhood Hits	273	Shared Neighborhood Hits	126
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP_MOUSE
θ value	0.0563607 (rank : 66)	NC score	0.364031 (rank : 16)
Query Neighborhood Hits	206	Target Neighborhood Hits	309	Shared Neighborhood Hits	133
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PPIP1_MOUSE
θ value	0.0563607 (rank : 67)	NC score	0.341038 (rank : 23)
Query Neighborhood Hits	206	Target Neighborhood Hits	377	Shared Neighborhood Hits	129
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ASPP1_HUMAN
θ value	0.0736092 (rank : 68)	NC score	0.178652 (rank : 118)
Query Neighborhood Hits	206	Target Neighborhood Hits	956	Shared Neighborhood Hits	115
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

FRK_HUMAN
θ value	0.0736092 (rank : 69)	NC score	0.166656 (rank : 141)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	129
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

GAK2_HUMAN
θ value	0.0736092 (rank : 70)	NC score	0.055475 (rank : 482)
Query Neighborhood Hits	206	Target Neighborhood Hits	406	Shared Neighborhood Hits	22
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GRAP2_HUMAN
θ value	0.0736092 (rank : 71)	NC score	0.387865 (rank : 12)
Query Neighborhood Hits	206	Target Neighborhood Hits	304	Shared Neighborhood Hits	135
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	0.0736092 (rank : 72)	NC score	0.389069 (rank : 11)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	133
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CIP4_HUMAN
θ value	0.0961366 (rank : 73)	NC score	0.217180 (rank : 72)
Query Neighborhood Hits	206	Target Neighborhood Hits	374	Shared Neighborhood Hits	72
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

GAK1_HUMAN
θ value	0.0961366 (rank : 74)	NC score	0.055321 (rank : 484)
Query Neighborhood Hits	206	Target Neighborhood Hits	268	Shared Neighborhood Hits	16
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

LCK_HUMAN
θ value	0.0961366 (rank : 75)	NC score	0.171698 (rank : 130)
Query Neighborhood Hits	206	Target Neighborhood Hits	987	Shared Neighborhood Hits	101
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

NPHP1_HUMAN
θ value	0.0961366 (rank : 76)	NC score	0.351180 (rank : 21)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	118
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SH3G3_MOUSE
θ value	0.0961366 (rank : 77)	NC score	0.255269 (rank : 48)
Query Neighborhood Hits	206	Target Neighborhood Hits	236	Shared Neighborhood Hits	119
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_MOUSE
θ value	0.0961366 (rank : 78)	NC score	0.271727 (rank : 38)
Query Neighborhood Hits	206	Target Neighborhood Hits	332	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_MOUSE
θ value	0.0961366 (rank : 79)	NC score	0.272487 (rank : 37)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	124
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

LCK_MOUSE
θ value	0.125558 (rank : 80)	NC score	0.170114 (rank : 132)
Query Neighborhood Hits	206	Target Neighborhood Hits	981	Shared Neighborhood Hits	101
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SH3G2_HUMAN
θ value	0.125558 (rank : 81)	NC score	0.241904 (rank : 55)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	122
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SNX18_HUMAN
θ value	0.125558 (rank : 82)	NC score	0.199518 (rank : 88)
Query Neighborhood Hits	206	Target Neighborhood Hits	207	Shared Neighborhood Hits	92
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ASPP1_MOUSE
θ value	0.163984 (rank : 83)	NC score	0.169279 (rank : 136)
Query Neighborhood Hits	206	Target Neighborhood Hits	1244	Shared Neighborhood Hits	122
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DDEF2_HUMAN
θ value	0.163984 (rank : 84)	NC score	0.117319 (rank : 187)
Query Neighborhood Hits	206	Target Neighborhood Hits	599	Shared Neighborhood Hits	93
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NCF1_MOUSE
θ value	0.163984 (rank : 85)	NC score	0.295583 (rank : 35)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NOXO1_MOUSE
θ value	0.163984 (rank : 86)	NC score	0.192952 (rank : 96)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	69
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

STAC3_HUMAN
θ value	0.163984 (rank : 87)	NC score	0.260590 (rank : 44)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	112
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DDEF2_MOUSE
θ value	0.21417 (rank : 88)	NC score	0.118248 (rank : 184)
Query Neighborhood Hits	206	Target Neighborhood Hits	625	Shared Neighborhood Hits	98
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GAK11_HUMAN
θ value	0.21417 (rank : 89)	NC score	0.054076 (rank : 493)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	22
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	0.21417 (rank : 90)	NC score	0.054116 (rank : 492)
Query Neighborhood Hits	206	Target Neighborhood Hits	415	Shared Neighborhood Hits	22
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK6_HUMAN
θ value	0.21417 (rank : 91)	NC score	0.054162 (rank : 491)
Query Neighborhood Hits	206	Target Neighborhood Hits	392	Shared Neighborhood Hits	23
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

NCF1_HUMAN
θ value	0.21417 (rank : 92)	NC score	0.307298 (rank : 33)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	114
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NOXO1_HUMAN
θ value	0.21417 (rank : 93)	NC score	0.174852 (rank : 123)
Query Neighborhood Hits	206	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SH3G2_MOUSE
θ value	0.21417 (rank : 94)	NC score	0.239469 (rank : 59)
Query Neighborhood Hits	206	Target Neighborhood Hits	319	Shared Neighborhood Hits	119
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

UBP36_HUMAN
θ value	0.21417 (rank : 95)	NC score	0.018034 (rank : 569)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

CSK_HUMAN
θ value	0.279714 (rank : 96)	NC score	0.146611 (rank : 151)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	112
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.279714 (rank : 97)	NC score	0.146580 (rank : 152)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	112
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PACN3_HUMAN
θ value	0.279714 (rank : 98)	NC score	0.204823 (rank : 80)
Query Neighborhood Hits	206	Target Neighborhood Hits	385	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SH3G1_HUMAN
θ value	0.279714 (rank : 99)	NC score	0.234708 (rank : 61)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	115
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SRBS1_HUMAN
θ value	0.279714 (rank : 100)	NC score	0.267119 (rank : 40)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	122
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MILK1_MOUSE
θ value	0.365318 (rank : 101)	NC score	0.019926 (rank : 562)
Query Neighborhood Hits	206	Target Neighborhood Hits	788	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MYO1F_MOUSE
θ value	0.365318 (rank : 102)	NC score	0.123691 (rank : 176)
Query Neighborhood Hits	206	Target Neighborhood Hits	262	Shared Neighborhood Hits	123
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

STAC3_MOUSE
θ value	0.365318 (rank : 103)	NC score	0.259106 (rank : 46)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TFCP2_HUMAN
θ value	0.365318 (rank : 104)	NC score	0.052146 (rank : 519)
Query Neighborhood Hits	206	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q12800, Q12801, Q9UD77	Gene names	TFCP2, LSF, SEF
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2 (Transcription factor LSF) (SAA3 enhancer factor).

TFCP2_MOUSE
θ value	0.365318 (rank : 105)	NC score	0.052176 (rank : 517)
Query Neighborhood Hits	206	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERA0, Q3UGJ4, Q8VC13	Gene names	Tcfcp2
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2.

ANR47_HUMAN
θ value	0.47712 (rank : 106)	NC score	0.017331 (rank : 570)
Query Neighborhood Hits	206	Target Neighborhood Hits	369	Shared Neighborhood Hits	12
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

CRK_HUMAN
θ value	0.47712 (rank : 107)	NC score	0.331756 (rank : 26)
Query Neighborhood Hits	206	Target Neighborhood Hits	308	Shared Neighborhood Hits	130
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

LTBP2_HUMAN
θ value	0.47712 (rank : 108)	NC score	0.005378 (rank : 599)
Query Neighborhood Hits	206	Target Neighborhood Hits	552	Shared Neighborhood Hits	7
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MRC2_MOUSE
θ value	0.47712 (rank : 109)	NC score	0.011993 (rank : 584)
Query Neighborhood Hits	206	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	Q64449, Q6ZQ64, Q8C6P0	Gene names	Mrc2, Kiaa0709
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Lectin lambda) (CD280 antigen).

NKX31_MOUSE
θ value	0.47712 (rank : 110)	NC score	0.007456 (rank : 595)
Query Neighborhood Hits	206	Target Neighborhood Hits	379	Shared Neighborhood Hits	7
SwissProt Accessions	P97436, O09087	Gene names	Nkx3-1, Nkx-3.1, Nkx3a
Domain Architecture
Description	Homeobox protein Nkx-3.1.

SH3G1_MOUSE
θ value	0.47712 (rank : 111)	NC score	0.234562 (rank : 62)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	118
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SNX18_MOUSE
θ value	0.47712 (rank : 112)	NC score	0.204783 (rank : 81)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	92
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHG6_MOUSE
θ value	0.62314 (rank : 113)	NC score	0.240131 (rank : 58)
Query Neighborhood Hits	206	Target Neighborhood Hits	394	Shared Neighborhood Hits	124
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DBNL_HUMAN
θ value	0.62314 (rank : 114)	NC score	0.184662 (rank : 114)
Query Neighborhood Hits	206	Target Neighborhood Hits	244	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

GRB2_HUMAN
θ value	0.62314 (rank : 115)	NC score	0.362641 (rank : 19)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	134
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.62314 (rank : 116)	NC score	0.361639 (rank : 20)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	134
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PTK6_MOUSE
θ value	0.62314 (rank : 117)	NC score	0.155674 (rank : 144)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	121
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SH3K1_HUMAN
θ value	0.62314 (rank : 118)	NC score	0.265475 (rank : 41)
Query Neighborhood Hits	206	Target Neighborhood Hits	341	Shared Neighborhood Hits	118
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SHLB2_HUMAN
θ value	0.62314 (rank : 119)	NC score	0.142801 (rank : 157)
Query Neighborhood Hits	206	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	0.62314 (rank : 120)	NC score	0.144171 (rank : 155)
Query Neighborhood Hits	206	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SNX9_MOUSE
θ value	0.62314 (rank : 121)	NC score	0.126864 (rank : 171)
Query Neighborhood Hits	206	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

AHI1_HUMAN
θ value	0.813845 (rank : 122)	NC score	0.247445 (rank : 51)
Query Neighborhood Hits	206	Target Neighborhood Hits	537	Shared Neighborhood Hits	130
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	0.813845 (rank : 123)	NC score	0.241230 (rank : 56)
Query Neighborhood Hits	206	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG7_MOUSE
θ value	0.813845 (rank : 124)	NC score	0.245571 (rank : 53)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	127
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

M3K9_HUMAN
θ value	0.813845 (rank : 125)	NC score	0.119503 (rank : 183)
Query Neighborhood Hits	206	Target Neighborhood Hits	1123	Shared Neighborhood Hits	127
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MEF2D_MOUSE
θ value	0.813845 (rank : 126)	NC score	0.018368 (rank : 566)
Query Neighborhood Hits	206	Target Neighborhood Hits	146	Shared Neighborhood Hits	9
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

PLCG2_HUMAN
θ value	0.813845 (rank : 127)	NC score	0.202898 (rank : 85)
Query Neighborhood Hits	206	Target Neighborhood Hits	280	Shared Neighborhood Hits	121
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

CECR2_HUMAN
θ value	1.06291 (rank : 128)	NC score	0.018334 (rank : 567)
Query Neighborhood Hits	206	Target Neighborhood Hits	543	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

MINT_MOUSE
θ value	1.06291 (rank : 129)	NC score	0.022417 (rank : 558)
Query Neighborhood Hits	206	Target Neighborhood Hits	1514	Shared Neighborhood Hits	35
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SFPQ_MOUSE
θ value	1.06291 (rank : 130)	NC score	0.026147 (rank : 553)
Query Neighborhood Hits	206	Target Neighborhood Hits	958	Shared Neighborhood Hits	30
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

ANM2_MOUSE
θ value	1.38821 (rank : 131)	NC score	0.181585 (rank : 117)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG7_HUMAN
θ value	1.38821 (rank : 132)	NC score	0.230285 (rank : 64)
Query Neighborhood Hits	206	Target Neighborhood Hits	347	Shared Neighborhood Hits	124
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DDEF1_MOUSE
θ value	1.38821 (rank : 133)	NC score	0.121942 (rank : 179)
Query Neighborhood Hits	206	Target Neighborhood Hits	592	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GAK12_HUMAN
θ value	1.38821 (rank : 134)	NC score	0.051924 (rank : 521)
Query Neighborhood Hits	206	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

IASPP_HUMAN
θ value	1.38821 (rank : 135)	NC score	0.160262 (rank : 143)
Query Neighborhood Hits	206	Target Neighborhood Hits	688	Shared Neighborhood Hits	121
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	1.38821 (rank : 136)	NC score	0.146333 (rank : 153)
Query Neighborhood Hits	206	Target Neighborhood Hits	1024	Shared Neighborhood Hits	129
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MAML3_HUMAN
θ value	1.38821 (rank : 137)	NC score	0.021299 (rank : 560)
Query Neighborhood Hits	206	Target Neighborhood Hits	323	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

PACN3_MOUSE
θ value	1.38821 (rank : 138)	NC score	0.200879 (rank : 87)
Query Neighborhood Hits	206	Target Neighborhood Hits	380	Shared Neighborhood Hits	114
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SLAP2_HUMAN
θ value	1.38821 (rank : 139)	NC score	0.265054 (rank : 42)
Query Neighborhood Hits	206	Target Neighborhood Hits	139	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

EFS_HUMAN
θ value	1.81305 (rank : 140)	NC score	0.190418 (rank : 105)
Query Neighborhood Hits	206	Target Neighborhood Hits	348	Shared Neighborhood Hits	110
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

GTSE1_MOUSE
θ value	1.81305 (rank : 141)	NC score	0.029144 (rank : 550)
Query Neighborhood Hits	206	Target Neighborhood Hits	245	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

SEPT4_HUMAN
θ value	1.81305 (rank : 142)	NC score	0.008080 (rank : 593)
Query Neighborhood Hits	206	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O43236, Q9UM58	Gene names	SEPT4, PNUTL2
Domain Architecture
Description	Septin-4 (Peanut-like protein 2) (Brain protein H5) (Cell division control-related protein 2) (hCDCREL-2) (Bradeion beta) (CE5B3 beta) (Cerebral protein 7).

SH3G3_HUMAN
θ value	1.81305 (rank : 143)	NC score	0.237435 (rank : 60)
Query Neighborhood Hits	206	Target Neighborhood Hits	222	Shared Neighborhood Hits	113
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SHAN1_HUMAN
θ value	1.81305 (rank : 144)	NC score	0.075043 (rank : 403)
Query Neighborhood Hits	206	Target Neighborhood Hits	1041	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SPTA3_MOUSE
θ value	1.81305 (rank : 145)	NC score	0.034682 (rank : 549)
Query Neighborhood Hits	206	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

ABI3_MOUSE
θ value	2.36792 (rank : 146)	NC score	0.197562 (rank : 90)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ANM2_HUMAN
θ value	2.36792 (rank : 147)	NC score	0.187286 (rank : 110)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	108
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CC036_HUMAN
θ value	2.36792 (rank : 148)	NC score	0.036860 (rank : 548)
Query Neighborhood Hits	206	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q3SXR2, Q3SXR3, Q9H6K8	Gene names	C3orf36
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf36.

CT2NL_HUMAN
θ value	2.36792 (rank : 149)	NC score	0.012699 (rank : 582)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

EFS_MOUSE
θ value	2.36792 (rank : 150)	NC score	0.206547 (rank : 78)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	109
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RCOR2_MOUSE
θ value	2.36792 (rank : 151)	NC score	0.013268 (rank : 580)
Query Neighborhood Hits	206	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C796, Q9JMK4	Gene names	Rcor2
Domain Architecture	No domain graphic available
Description	REST corepressor 2 (M-CoREST).

SLAP1_HUMAN
θ value	2.36792 (rank : 152)	NC score	0.255532 (rank : 47)
Query Neighborhood Hits	206	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

TRIO_HUMAN
θ value	2.36792 (rank : 153)	NC score	0.070449 (rank : 419)
Query Neighborhood Hits	206	Target Neighborhood Hits	1580	Shared Neighborhood Hits	82
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TRPV4_HUMAN
θ value	2.36792 (rank : 154)	NC score	0.008854 (rank : 592)
Query Neighborhood Hits	206	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

VAV2_MOUSE
θ value	2.36792 (rank : 155)	NC score	0.213074 (rank : 74)
Query Neighborhood Hits	206	Target Neighborhood Hits	456	Shared Neighborhood Hits	126
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

XBP1_HUMAN
θ value	2.36792 (rank : 156)	NC score	0.020454 (rank : 561)
Query Neighborhood Hits	206	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P17861, Q8WYK6, Q969P1, Q96BD7	Gene names	XBP1, TREB5, XBP2
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5).

ABI3_HUMAN
θ value	3.0926 (rank : 157)	NC score	0.194542 (rank : 95)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BAG3_MOUSE
θ value	3.0926 (rank : 158)	NC score	0.022499 (rank : 557)
Query Neighborhood Hits	206	Target Neighborhood Hits	513	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CKAP2_HUMAN
θ value	3.0926 (rank : 159)	NC score	0.018792 (rank : 564)
Query Neighborhood Hits	206	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWK9, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4	Gene names	CKAP2, LB1, TMAP
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2 (Tumor-associated microtubule- associated protein) (CTCL tumor antigen se20-10).

CN105_MOUSE
θ value	3.0926 (rank : 160)	NC score	0.021426 (rank : 559)
Query Neighborhood Hits	206	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CPZ1, Q8R0Q0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf105 homolog.

K0141_HUMAN
θ value	3.0926 (rank : 161)	NC score	0.018509 (rank : 565)
Query Neighborhood Hits	206	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

KIF1C_HUMAN
θ value	3.0926 (rank : 162)	NC score	0.003524 (rank : 602)
Query Neighborhood Hits	206	Target Neighborhood Hits	128	Shared Neighborhood Hits	4
SwissProt Accessions	O43896, O75186	Gene names	KIF1C, KIAA0706
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF1C.

MAST1_MOUSE
θ value	3.0926 (rank : 163)	NC score	0.028987 (rank : 552)
Query Neighborhood Hits	206	Target Neighborhood Hits	1123	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MYO1F_HUMAN
θ value	3.0926 (rank : 164)	NC score	0.120923 (rank : 180)
Query Neighborhood Hits	206	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

PCQAP_HUMAN
θ value	3.0926 (rank : 165)	NC score	0.024182 (rank : 554)
Query Neighborhood Hits	206	Target Neighborhood Hits	549	Shared Neighborhood Hits	23
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

RHG05_HUMAN
θ value	3.0926 (rank : 166)	NC score	0.008897 (rank : 591)
Query Neighborhood Hits	206	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RIMB1_MOUSE
θ value	3.0926 (rank : 167)	NC score	0.076682 (rank : 388)
Query Neighborhood Hits	206	Target Neighborhood Hits	1376	Shared Neighborhood Hits	111
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SFPQ_HUMAN
θ value	3.0926 (rank : 168)	NC score	0.019434 (rank : 563)
Query Neighborhood Hits	206	Target Neighborhood Hits	986	Shared Neighborhood Hits	32
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SLAP1_MOUSE
θ value	3.0926 (rank : 169)	NC score	0.251258 (rank : 49)
Query Neighborhood Hits	206	Target Neighborhood Hits	117	Shared Neighborhood Hits	49
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

VAV2_HUMAN
θ value	3.0926 (rank : 170)	NC score	0.213253 (rank : 73)
Query Neighborhood Hits	206	Target Neighborhood Hits	453	Shared Neighborhood Hits	128
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CCNB3_HUMAN
θ value	4.03905 (rank : 171)	NC score	0.009903 (rank : 589)
Query Neighborhood Hits	206	Target Neighborhood Hits	368	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

GA2L2_MOUSE
θ value	4.03905 (rank : 172)	NC score	0.016013 (rank : 572)
Query Neighborhood Hits	206	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GAK3_HUMAN
θ value	4.03905 (rank : 173)	NC score	0.049834 (rank : 546)
Query Neighborhood Hits	206	Target Neighborhood Hits	182	Shared Neighborhood Hits	12
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MA1B1_HUMAN
θ value	4.03905 (rank : 174)	NC score	0.011604 (rank : 586)
Query Neighborhood Hits	206	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

MKL1_HUMAN
θ value	4.03905 (rank : 175)	NC score	0.011812 (rank : 585)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

MMP24_HUMAN
θ value	4.03905 (rank : 176)	NC score	0.012767 (rank : 581)
Query Neighborhood Hits	206	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

TRI47_MOUSE
θ value	4.03905 (rank : 177)	NC score	0.005234 (rank : 600)
Query Neighborhood Hits	206	Target Neighborhood Hits	295	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

AMELY_HUMAN
θ value	5.27518 (rank : 178)	NC score	0.016279 (rank : 571)
Query Neighborhood Hits	206	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q99218, Q6RWT1	Gene names	AMELY, AMGL, AMGY
Domain Architecture
Description	Amelogenin, Y isoform precursor.

ERBB2_HUMAN
θ value	5.27518 (rank : 179)	NC score	0.096632 (rank : 234)
Query Neighborhood Hits	206	Target Neighborhood Hits	1073	Shared Neighborhood Hits	47
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

INHBA_HUMAN
θ value	5.27518 (rank : 180)	NC score	0.004355 (rank : 601)
Query Neighborhood Hits	206	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P08476, Q14599	Gene names	INHBA
Domain Architecture
Description	Inhibin beta A chain precursor (Activin beta-A chain) (Erythroid differentiation protein) (EDF).

MMP24_MOUSE
θ value	5.27518 (rank : 181)	NC score	0.012117 (rank : 583)
Query Neighborhood Hits	206	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

RERE_MOUSE
θ value	5.27518 (rank : 182)	NC score	0.014580 (rank : 576)
Query Neighborhood Hits	206	Target Neighborhood Hits	785	Shared Neighborhood Hits	28
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TP53B_MOUSE
θ value	5.27518 (rank : 183)	NC score	0.014266 (rank : 577)
Query Neighborhood Hits	206	Target Neighborhood Hits	644	Shared Neighborhood Hits	20
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

UBP2L_HUMAN
θ value	5.27518 (rank : 184)	NC score	0.023360 (rank : 556)
Query Neighborhood Hits	206	Target Neighborhood Hits	170	Shared Neighborhood Hits	10
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

UBP2L_MOUSE
θ value	5.27518 (rank : 185)	NC score	0.023641 (rank : 555)
Query Neighborhood Hits	206	Target Neighborhood Hits	173	Shared Neighborhood Hits	12
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

WASF2_MOUSE
θ value	5.27518 (rank : 186)	NC score	0.014809 (rank : 575)
Query Neighborhood Hits	206	Target Neighborhood Hits	315	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

ZAR1_MOUSE
θ value	5.27518 (rank : 187)	NC score	0.015173 (rank : 574)
Query Neighborhood Hits	206	Target Neighborhood Hits	254	Shared Neighborhood Hits	10
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ARI1A_HUMAN
θ value	6.88961 (rank : 188)	NC score	0.018238 (rank : 568)
Query Neighborhood Hits	206	Target Neighborhood Hits	787	Shared Neighborhood Hits	32
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

CARD6_HUMAN
θ value	6.88961 (rank : 189)	NC score	0.013382 (rank : 579)
Query Neighborhood Hits	206	Target Neighborhood Hits	145	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

DCX_MOUSE
θ value	6.88961 (rank : 190)	NC score	0.006263 (rank : 598)
Query Neighborhood Hits	206	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

GA2L1_MOUSE
θ value	6.88961 (rank : 191)	NC score	0.013770 (rank : 578)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

LAEVR_HUMAN
θ value	6.88961 (rank : 192)	NC score	0.006737 (rank : 596)
Query Neighborhood Hits	206	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

LMAN1_MOUSE
θ value	6.88961 (rank : 193)	NC score	0.007639 (rank : 594)
Query Neighborhood Hits	206	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D0F3	Gene names	Lman1, Ergic53
Domain Architecture
Description	ERGIC-53 protein precursor (ER-Golgi intermediate compartment 53 kDa protein) (Lectin, mannose-binding 1) (p58).

MAST1_HUMAN
θ value	6.88961 (rank : 194)	NC score	0.029019 (rank : 551)
Query Neighborhood Hits	206	Target Neighborhood Hits	1146	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PER1_HUMAN
θ value	6.88961 (rank : 195)	NC score	0.006379 (rank : 597)
Query Neighborhood Hits	206	Target Neighborhood Hits	215	Shared Neighborhood Hits	8
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

TRI66_MOUSE
θ value	6.88961 (rank : 196)	NC score	0.010625 (rank : 588)
Query Neighborhood Hits	206	Target Neighborhood Hits	491	Shared Neighborhood Hits	21
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

XRCC4_HUMAN
θ value	6.88961 (rank : 197)	NC score	0.010739 (rank : 587)
Query Neighborhood Hits	206	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q13426, Q9BS72, Q9UP94	Gene names	XRCC4
Domain Architecture
Description	DNA-repair protein XRCC4 (X-ray repair cross-complementing protein 4).

ARHG6_HUMAN
θ value	8.99809 (rank : 198)	NC score	0.220632 (rank : 67)
Query Neighborhood Hits	206	Target Neighborhood Hits	376	Shared Neighborhood Hits	119
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARTN_HUMAN
θ value	8.99809 (rank : 199)	NC score	0.009728 (rank : 590)
Query Neighborhood Hits	206	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T4W7, O95441, O96030, Q6P6A3	Gene names	ARTN, EVN
Domain Architecture	No domain graphic available
Description	Artemin precursor (Enovin) (Neublastin).

CAC1C_HUMAN
θ value	8.99809 (rank : 200)	NC score	0.001893 (rank : 605)
Query Neighborhood Hits	206	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

FOXC2_HUMAN
θ value	8.99809 (rank : 201)	NC score	0.002721 (rank : 604)
Query Neighborhood Hits	206	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q99958	Gene names	FOXC2, FKHL14, MFH1
Domain Architecture
Description	Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14).

KCNQ3_HUMAN
θ value	8.99809 (rank : 202)	NC score	0.002742 (rank : 603)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

MYO15_MOUSE
θ value	8.99809 (rank : 203)	NC score	0.015430 (rank : 573)
Query Neighborhood Hits	206	Target Neighborhood Hits	467	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PASK_HUMAN
θ value	8.99809 (rank : 204)	NC score	0.041273 (rank : 547)
Query Neighborhood Hits	206	Target Neighborhood Hits	857	Shared Neighborhood Hits	43
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PO2F2_MOUSE
θ value	8.99809 (rank : 205)	NC score	0.000599 (rank : 606)
Query Neighborhood Hits	206	Target Neighborhood Hits	353	Shared Neighborhood Hits	3
SwissProt Accessions	Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q61995, Q61996, Q64245	Gene names	Pou2f2, Oct2, Otf2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).

RUSC1_HUMAN
θ value	8.99809 (rank : 206)	NC score	0.140619 (rank : 159)
Query Neighborhood Hits	206	Target Neighborhood Hits	226	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

AATK_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.095632 (rank : 240)
Query Neighborhood Hits	206	Target Neighborhood Hits	1243	Shared Neighborhood Hits	60
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.096068 (rank : 237)
Query Neighborhood Hits	206	Target Neighborhood Hits	942	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI1_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.172586 (rank : 128)
Query Neighborhood Hits	206	Target Neighborhood Hits	257	Shared Neighborhood Hits	107
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.181740 (rank : 116)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	110
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.203035 (rank : 84)
Query Neighborhood Hits	206	Target Neighborhood Hits	350	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.204212 (rank : 82)
Query Neighborhood Hits	206	Target Neighborhood Hits	266	Shared Neighborhood Hits	114
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ACK1_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.105106 (rank : 209)
Query Neighborhood Hits	206	Target Neighborhood Hits	1140	Shared Neighborhood Hits	76
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.105446 (rank : 208)
Query Neighborhood Hits	206	Target Neighborhood Hits	1080	Shared Neighborhood Hits	79
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.066828 (rank : 438)
Query Neighborhood Hits	206	Target Neighborhood Hits	753	Shared Neighborhood Hits	40
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.066844 (rank : 437)
Query Neighborhood Hits	206	Target Neighborhood Hits	753	Shared Neighborhood Hits	40
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.067778 (rank : 432)
Query Neighborhood Hits	206	Target Neighborhood Hits	709	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.068100 (rank : 430)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.069856 (rank : 422)
Query Neighborhood Hits	206	Target Neighborhood Hits	716	Shared Neighborhood Hits	39
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.069850 (rank : 423)
Query Neighborhood Hits	206	Target Neighborhood Hits	739	Shared Neighborhood Hits	39
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.064170 (rank : 457)
Query Neighborhood Hits	206	Target Neighborhood Hits	760	Shared Neighborhood Hits	39
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.064518 (rank : 452)
Query Neighborhood Hits	206	Target Neighborhood Hits	768	Shared Neighborhood Hits	39
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AL2S2_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.050909 (rank : 526)
Query Neighborhood Hits	206	Target Neighborhood Hits	709	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.050896 (rank : 527)
Query Neighborhood Hits	206	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.099626 (rank : 229)
Query Neighborhood Hits	206	Target Neighborhood Hits	795	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.099928 (rank : 228)
Query Neighborhood Hits	206	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.064476 (rank : 453)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AMPH_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.069392 (rank : 424)
Query Neighborhood Hits	206	Target Neighborhood Hits	455	Shared Neighborhood Hits	61
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.056909 (rank : 475)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANKK1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.065887 (rank : 441)
Query Neighborhood Hits	206	Target Neighborhood Hits	1075	Shared Neighborhood Hits	52
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.065440 (rank : 443)
Query Neighborhood Hits	206	Target Neighborhood Hits	1072	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.083944 (rank : 346)
Query Neighborhood Hits	206	Target Neighborhood Hits	612	Shared Neighborhood Hits	38
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.084045 (rank : 345)
Query Neighborhood Hits	206	Target Neighborhood Hits	600	Shared Neighborhood Hits	38
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.079588 (rank : 377)
Query Neighborhood Hits	206	Target Neighborhood Hits	646	Shared Neighborhood Hits	39
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.080285 (rank : 369)
Query Neighborhood Hits	206	Target Neighborhood Hits	607	Shared Neighborhood Hits	39
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APS_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.091820 (rank : 279)
Query Neighborhood Hits	206	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.064261 (rank : 456)
Query Neighborhood Hits	206	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARAF_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.080183 (rank : 371)
Query Neighborhood Hits	206	Target Neighborhood Hits	924	Shared Neighborhood Hits	46
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.080865 (rank : 364)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG3_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.056384 (rank : 477)
Query Neighborhood Hits	206	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.056169 (rank : 478)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.147183 (rank : 150)
Query Neighborhood Hits	206	Target Neighborhood Hits	242	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.105744 (rank : 207)
Query Neighborhood Hits	206	Target Neighborhood Hits	185	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.072199 (rank : 415)
Query Neighborhood Hits	206	Target Neighborhood Hits	172	Shared Neighborhood Hits	56
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.051433 (rank : 524)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.052916 (rank : 507)
Query Neighborhood Hits	206	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.125898 (rank : 174)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	100
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.127457 (rank : 170)
Query Neighborhood Hits	206	Target Neighborhood Hits	234	Shared Neighborhood Hits	101
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGG_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.056759 (rank : 476)
Query Neighborhood Hits	206	Target Neighborhood Hits	152	Shared Neighborhood Hits	36
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.123640 (rank : 177)
Query Neighborhood Hits	206	Target Neighborhood Hits	1156	Shared Neighborhood Hits	114
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AVR2A_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.052521 (rank : 515)
Query Neighborhood Hits	206	Target Neighborhood Hits	767	Shared Neighborhood Hits	40
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.052523 (rank : 514)
Query Neighborhood Hits	206	Target Neighborhood Hits	767	Shared Neighborhood Hits	40
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.054324 (rank : 490)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.054482 (rank : 489)
Query Neighborhood Hits	206	Target Neighborhood Hits	749	Shared Neighborhood Hits	40
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

BCAR1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.175529 (rank : 122)
Query Neighborhood Hits	206	Target Neighborhood Hits	554	Shared Neighborhood Hits	130
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.176485 (rank : 120)
Query Neighborhood Hits	206	Target Neighborhood Hits	438	Shared Neighborhood Hits	130
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BLNK_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.057775 (rank : 472)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.058512 (rank : 470)
Query Neighborhood Hits	206	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMPR2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.053558 (rank : 501)
Query Neighborhood Hits	206	Target Neighborhood Hits	736	Shared Neighborhood Hits	39
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.053022 (rank : 506)
Query Neighborhood Hits	206	Target Neighborhood Hits	738	Shared Neighborhood Hits	39
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.072858 (rank : 414)
Query Neighborhood Hits	206	Target Neighborhood Hits	759	Shared Neighborhood Hits	40
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.073021 (rank : 413)
Query Neighborhood Hits	206	Target Neighborhood Hits	758	Shared Neighborhood Hits	40
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.075416 (rank : 398)
Query Neighborhood Hits	206	Target Neighborhood Hits	760	Shared Neighborhood Hits	40
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.075684 (rank : 394)
Query Neighborhood Hits	206	Target Neighborhood Hits	758	Shared Neighborhood Hits	40
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.119680 (rank : 182)
Query Neighborhood Hits	206	Target Neighborhood Hits	942	Shared Neighborhood Hits	55
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.120389 (rank : 181)
Query Neighborhood Hits	206	Target Neighborhood Hits	912	Shared Neighborhood Hits	55
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.079851 (rank : 375)
Query Neighborhood Hits	206	Target Neighborhood Hits	883	Shared Neighborhood Hits	48
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CASL_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.138000 (rank : 163)
Query Neighborhood Hits	206	Target Neighborhood Hits	259	Shared Neighborhood Hits	98
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.138380 (rank : 161)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	102
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.264958 (rank : 43)
Query Neighborhood Hits	206	Target Neighborhood Hits	315	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.278735 (rank : 36)
Query Neighborhood Hits	206	Target Neighborhood Hits	336	Shared Neighborhood Hits	125
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2L7_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.050176 (rank : 541)
Query Neighborhood Hits	206	Target Neighborhood Hits	1275	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CI096_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.058952 (rank : 467)
Query Neighborhood Hits	206	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CRK_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.328701 (rank : 29)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	130
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CSF1R_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.092883 (rank : 263)
Query Neighborhood Hits	206	Target Neighborhood Hits	943	Shared Neighborhood Hits	40
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.089898 (rank : 302)
Query Neighborhood Hits	206	Target Neighborhood Hits	983	Shared Neighborhood Hits	40
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CT032_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.138144 (rank : 162)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.132978 (rank : 165)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.130351 (rank : 167)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.178205 (rank : 119)
Query Neighborhood Hits	206	Target Neighborhood Hits	306	Shared Neighborhood Hits	110
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDR1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.096848 (rank : 233)
Query Neighborhood Hits	206	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.097386 (rank : 232)
Query Neighborhood Hits	206	Target Neighborhood Hits	818	Shared Neighborhood Hits	40
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.092191 (rank : 268)
Query Neighborhood Hits	206	Target Neighborhood Hits	818	Shared Neighborhood Hits	40
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.092170 (rank : 270)
Query Neighborhood Hits	206	Target Neighborhood Hits	813	Shared Neighborhood Hits	40
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DOCK1_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.067919 (rank : 431)
Query Neighborhood Hits	206	Target Neighborhood Hits	191	Shared Neighborhood Hits	81
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

E2AK1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.050203 (rank : 540)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.051711 (rank : 523)
Query Neighborhood Hits	206	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

EGFR_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.091883 (rank : 276)
Query Neighborhood Hits	206	Target Neighborhood Hits	939	Shared Neighborhood Hits	41
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.091893 (rank : 275)
Query Neighborhood Hits	206	Target Neighborhood Hits	927	Shared Neighborhood Hits	40
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.091042 (rank : 291)
Query Neighborhood Hits	206	Target Neighborhood Hits	997	Shared Neighborhood Hits	42
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.091401 (rank : 287)
Query Neighborhood Hits	206	Target Neighborhood Hits	958	Shared Neighborhood Hits	41
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.090250 (rank : 300)
Query Neighborhood Hits	206	Target Neighborhood Hits	1021	Shared Neighborhood Hits	41
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.090390 (rank : 299)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	41
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.087320 (rank : 326)
Query Neighborhood Hits	206	Target Neighborhood Hits	1005	Shared Neighborhood Hits	41
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.087491 (rank : 325)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	41
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.088647 (rank : 316)
Query Neighborhood Hits	206	Target Neighborhood Hits	975	Shared Neighborhood Hits	40
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.088606 (rank : 317)
Query Neighborhood Hits	206	Target Neighborhood Hits	982	Shared Neighborhood Hits	40
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.088294 (rank : 319)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.092129 (rank : 272)
Query Neighborhood Hits	206	Target Neighborhood Hits	950	Shared Neighborhood Hits	40
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.092819 (rank : 265)
Query Neighborhood Hits	206	Target Neighborhood Hits	959	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.092722 (rank : 266)
Query Neighborhood Hits	206	Target Neighborhood Hits	946	Shared Neighborhood Hits	41
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.086838 (rank : 329)
Query Neighborhood Hits	206	Target Neighborhood Hits	1053	Shared Neighborhood Hits	42
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.086776 (rank : 330)
Query Neighborhood Hits	206	Target Neighborhood Hits	1025	Shared Neighborhood Hits	41
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.089008 (rank : 312)
Query Neighborhood Hits	206	Target Neighborhood Hits	956	Shared Neighborhood Hits	40
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.089173 (rank : 310)
Query Neighborhood Hits	206	Target Neighborhood Hits	969	Shared Neighborhood Hits	41
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.094991 (rank : 244)
Query Neighborhood Hits	206	Target Neighborhood Hits	960	Shared Neighborhood Hits	40
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.087752 (rank : 322)
Query Neighborhood Hits	206	Target Neighborhood Hits	988	Shared Neighborhood Hits	42
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.088986 (rank : 314)
Query Neighborhood Hits	206	Target Neighborhood Hits	983	Shared Neighborhood Hits	41
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.089016 (rank : 311)
Query Neighborhood Hits	206	Target Neighborhood Hits	982	Shared Neighborhood Hits	41
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.089233 (rank : 309)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	42
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.089322 (rank : 306)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	42
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.089751 (rank : 303)
Query Neighborhood Hits	206	Target Neighborhood Hits	1056	Shared Neighborhood Hits	41
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.089314 (rank : 308)
Query Neighborhood Hits	206	Target Neighborhood Hits	1013	Shared Neighborhood Hits	41
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.094433 (rank : 247)
Query Neighborhood Hits	206	Target Neighborhood Hits	912	Shared Neighborhood Hits	40
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.093349 (rank : 262)
Query Neighborhood Hits	206	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.095251 (rank : 241)
Query Neighborhood Hits	206	Target Neighborhood Hits	918	Shared Neighborhood Hits	42
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.095052 (rank : 243)
Query Neighborhood Hits	206	Target Neighborhood Hits	918	Shared Neighborhood Hits	40
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.094283 (rank : 250)
Query Neighborhood Hits	206	Target Neighborhood Hits	898	Shared Neighborhood Hits	39
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.094097 (rank : 252)
Query Neighborhood Hits	206	Target Neighborhood Hits	910	Shared Neighborhood Hits	42
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

FAK1_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.091844 (rank : 278)
Query Neighborhood Hits	206	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.091849 (rank : 277)
Query Neighborhood Hits	206	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.096279 (rank : 235)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	41
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.095962 (rank : 238)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FER_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.108748 (rank : 202)
Query Neighborhood Hits	206	Target Neighborhood Hits	1278	Shared Neighborhood Hits	69
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.100037 (rank : 227)
Query Neighborhood Hits	206	Target Neighborhood Hits	978	Shared Neighborhood Hits	49
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.099243 (rank : 230)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR1_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.083499 (rank : 350)
Query Neighborhood Hits	206	Target Neighborhood Hits	1069	Shared Neighborhood Hits	40
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.083505 (rank : 349)
Query Neighborhood Hits	206	Target Neighborhood Hits	1068	Shared Neighborhood Hits	40
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.083670 (rank : 348)
Query Neighborhood Hits	206	Target Neighborhood Hits	1062	Shared Neighborhood Hits	40
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.084077 (rank : 344)
Query Neighborhood Hits	206	Target Neighborhood Hits	1062	Shared Neighborhood Hits	40
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.084604 (rank : 340)
Query Neighborhood Hits	206	Target Neighborhood Hits	1042	Shared Neighborhood Hits	40
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.084210 (rank : 343)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	40
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.087236 (rank : 327)
Query Neighborhood Hits	206	Target Neighborhood Hits	1037	Shared Neighborhood Hits	40
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.088994 (rank : 313)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	40
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLT3_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.093918 (rank : 255)
Query Neighborhood Hits	206	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.094374 (rank : 248)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FNBP2_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.112416 (rank : 195)
Query Neighborhood Hits	206	Target Neighborhood Hits	432	Shared Neighborhood Hits	103
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRB10_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.073472 (rank : 406)
Query Neighborhood Hits	206	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.076065 (rank : 391)
Query Neighborhood Hits	206	Target Neighborhood Hits	156	Shared Neighborhood Hits	48
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.104668 (rank : 212)
Query Neighborhood Hits	206	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.108248 (rank : 204)
Query Neighborhood Hits	206	Target Neighborhood Hits	149	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.078220 (rank : 384)
Query Neighborhood Hits	206	Target Neighborhood Hits	156	Shared Neighborhood Hits	48
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.087721 (rank : 323)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GUC2C_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.081613 (rank : 358)
Query Neighborhood Hits	206	Target Neighborhood Hits	624	Shared Neighborhood Hits	38
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.076249 (rank : 390)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.075595 (rank : 397)
Query Neighborhood Hits	206	Target Neighborhood Hits	692	Shared Neighborhood Hits	39
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.085583 (rank : 333)
Query Neighborhood Hits	206	Target Neighborhood Hits	740	Shared Neighborhood Hits	40
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.079497 (rank : 378)
Query Neighborhood Hits	206	Target Neighborhood Hits	644	Shared Neighborhood Hits	38
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCLS1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.195835 (rank : 93)
Query Neighborhood Hits	206	Target Neighborhood Hits	358	Shared Neighborhood Hits	117
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.199380 (rank : 89)
Query Neighborhood Hits	206	Target Neighborhood Hits	329	Shared Neighborhood Hits	118
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HSH2D_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.104309 (rank : 213)
Query Neighborhood Hits	206	Target Neighborhood Hits	159	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.060795 (rank : 462)
Query Neighborhood Hits	206	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ICK_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.050045 (rank : 544)
Query Neighborhood Hits	206	Target Neighborhood Hits	867	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

IGF1R_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.094362 (rank : 249)
Query Neighborhood Hits	206	Target Neighborhood Hits	977	Shared Neighborhood Hits	41
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.094607 (rank : 245)
Query Neighborhood Hits	206	Target Neighborhood Hits	973	Shared Neighborhood Hits	41
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ILK1_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.091242 (rank : 289)
Query Neighborhood Hits	206	Target Neighborhood Hits	857	Shared Neighborhood Hits	49
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.090521 (rank : 296)
Query Neighborhood Hits	206	Target Neighborhood Hits	848	Shared Neighborhood Hits	49
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.091771 (rank : 282)
Query Neighborhood Hits	206	Target Neighborhood Hits	858	Shared Neighborhood Hits	49
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.094046 (rank : 253)
Query Neighborhood Hits	206	Target Neighborhood Hits	950	Shared Neighborhood Hits	42
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.093988 (rank : 254)
Query Neighborhood Hits	206	Target Neighborhood Hits	961	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.091970 (rank : 274)
Query Neighborhood Hits	206	Target Neighborhood Hits	963	Shared Neighborhood Hits	40
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.091804 (rank : 281)
Query Neighborhood Hits	206	Target Neighborhood Hits	968	Shared Neighborhood Hits	40
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.073226 (rank : 412)
Query Neighborhood Hits	206	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.076672 (rank : 389)
Query Neighborhood Hits	206	Target Neighborhood Hits	784	Shared Neighborhood Hits	40
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.075231 (rank : 402)
Query Neighborhood Hits	206	Target Neighborhood Hits	714	Shared Neighborhood Hits	42
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.079420 (rank : 380)
Query Neighborhood Hits	206	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.083166 (rank : 352)
Query Neighborhood Hits	206	Target Neighborhood Hits	628	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.071786 (rank : 417)
Query Neighborhood Hits	206	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.069114 (rank : 425)
Query Neighborhood Hits	206	Target Neighborhood Hits	820	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

JAK1_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.083256 (rank : 351)
Query Neighborhood Hits	206	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.083152 (rank : 353)
Query Neighborhood Hits	206	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.078542 (rank : 382)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.078806 (rank : 381)
Query Neighborhood Hits	206	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.081697 (rank : 355)
Query Neighborhood Hits	206	Target Neighborhood Hits	827	Shared Neighborhood Hits	40
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.078535 (rank : 383)
Query Neighborhood Hits	206	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KIT_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.090151 (rank : 301)
Query Neighborhood Hits	206	Target Neighborhood Hits	953	Shared Neighborhood Hits	40
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.090940 (rank : 292)
Query Neighborhood Hits	206	Target Neighborhood Hits	949	Shared Neighborhood Hits	41
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSR1_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.075292 (rank : 400)
Query Neighborhood Hits	206	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.074086 (rank : 405)
Query Neighborhood Hits	206	Target Neighborhood Hits	870	Shared Neighborhood Hits	43
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.075752 (rank : 393)
Query Neighborhood Hits	206	Target Neighborhood Hits	920	Shared Neighborhood Hits	51
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.102129 (rank : 219)
Query Neighborhood Hits	206	Target Neighborhood Hits	901	Shared Neighborhood Hits	59
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.102863 (rank : 217)
Query Neighborhood Hits	206	Target Neighborhood Hits	944	Shared Neighborhood Hits	62
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LASP1_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.169811 (rank : 133)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	108
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.169565 (rank : 134)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	108
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LCP2_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.075671 (rank : 395)
Query Neighborhood Hits	206	Target Neighborhood Hits	531	Shared Neighborhood Hits	57
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.074947 (rank : 404)
Query Neighborhood Hits	206	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LIMK1_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.068363 (rank : 428)
Query Neighborhood Hits	206	Target Neighborhood Hits	1005	Shared Neighborhood Hits	41
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.068159 (rank : 429)
Query Neighborhood Hits	206	Target Neighborhood Hits	1008	Shared Neighborhood Hits	41
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.064880 (rank : 449)
Query Neighborhood Hits	206	Target Neighborhood Hits	986	Shared Neighborhood Hits	41
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.064984 (rank : 446)
Query Neighborhood Hits	206	Target Neighborhood Hits	998	Shared Neighborhood Hits	41
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LNK_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.085413 (rank : 334)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.080967 (rank : 363)
Query Neighborhood Hits	206	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRRK1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.060100 (rank : 463)
Query Neighborhood Hits	206	Target Neighborhood Hits	1237	Shared Neighborhood Hits	43
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.060914 (rank : 461)
Query Neighborhood Hits	206	Target Neighborhood Hits	1267	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.059911 (rank : 464)
Query Neighborhood Hits	206	Target Neighborhood Hits	1382	Shared Neighborhood Hits	40
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.059405 (rank : 466)
Query Neighborhood Hits	206	Target Neighborhood Hits	1359	Shared Neighborhood Hits	40
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.100923 (rank : 222)
Query Neighborhood Hits	206	Target Neighborhood Hits	774	Shared Neighborhood Hits	39
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.100376 (rank : 224)
Query Neighborhood Hits	206	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K11_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.115706 (rank : 189)
Query Neighborhood Hits	206	Target Neighborhood Hits	1136	Shared Neighborhood Hits	122
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.075305 (rank : 399)
Query Neighborhood Hits	206	Target Neighborhood Hits	940	Shared Neighborhood Hits	40
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.075239 (rank : 401)
Query Neighborhood Hits	206	Target Neighborhood Hits	957	Shared Neighborhood Hits	40
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.075994 (rank : 392)
Query Neighborhood Hits	206	Target Neighborhood Hits	911	Shared Neighborhood Hits	44
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K7_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.073262 (rank : 411)
Query Neighborhood Hits	206	Target Neighborhood Hits	892	Shared Neighborhood Hits	40
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.073284 (rank : 410)
Query Neighborhood Hits	206	Target Neighborhood Hits	892	Shared Neighborhood Hits	40
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M4K4_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.052158 (rank : 518)
Query Neighborhood Hits	206	Target Neighborhood Hits	1560	Shared Neighborhood Hits	53
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.050286 (rank : 536)
Query Neighborhood Hits	206	Target Neighborhood Hits	873	Shared Neighborhood Hits	41
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MATK_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.117642 (rank : 186)
Query Neighborhood Hits	206	Target Neighborhood Hits	954	Shared Neighborhood Hits	69
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.118017 (rank : 185)
Query Neighborhood Hits	206	Target Neighborhood Hits	952	Shared Neighborhood Hits	76
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.061894 (rank : 460)
Query Neighborhood Hits	206	Target Neighborhood Hits	255	Shared Neighborhood Hits	34
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MERTK_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.093633 (rank : 258)
Query Neighborhood Hits	206	Target Neighborhood Hits	988	Shared Neighborhood Hits	39
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.093454 (rank : 261)
Query Neighborhood Hits	206	Target Neighborhood Hits	974	Shared Neighborhood Hits	42
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.090492 (rank : 297)
Query Neighborhood Hits	206	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.090939 (rank : 293)
Query Neighborhood Hits	206	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLKL_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.087139 (rank : 328)
Query Neighborhood Hits	206	Target Neighborhood Hits	600	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.085230 (rank : 335)
Query Neighborhood Hits	206	Target Neighborhood Hits	707	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.080601 (rank : 366)
Query Neighborhood Hits	206	Target Neighborhood Hits	911	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.080524 (rank : 367)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.080471 (rank : 368)
Query Neighborhood Hits	206	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.079886 (rank : 374)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	41
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K2_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.050228 (rank : 539)
Query Neighborhood Hits	206	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.050266 (rank : 537)
Query Neighborhood Hits	206	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K5_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.050667 (rank : 530)
Query Neighborhood Hits	206	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K7_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.050313 (rank : 533)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.053652 (rank : 499)
Query Neighborhood Hits	206	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.053575 (rank : 500)
Query Neighborhood Hits	206	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MUSK_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.086087 (rank : 332)
Query Neighborhood Hits	206	Target Neighborhood Hits	1074	Shared Neighborhood Hits	40
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.086362 (rank : 331)
Query Neighborhood Hits	206	Target Neighborhood Hits	1057	Shared Neighborhood Hits	40
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYLK2_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.053053 (rank : 505)
Query Neighborhood Hits	206	Target Neighborhood Hits	920	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NCF4_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.167936 (rank : 138)
Query Neighborhood Hits	206	Target Neighborhood Hits	161	Shared Neighborhood Hits	84
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.186134 (rank : 112)
Query Neighborhood Hits	206	Target Neighborhood Hits	177	Shared Neighborhood Hits	93
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.141607 (rank : 158)
Query Neighborhood Hits	206	Target Neighborhood Hits	457	Shared Neighborhood Hits	107
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.126274 (rank : 173)
Query Neighborhood Hits	206	Target Neighborhood Hits	420	Shared Neighborhood Hits	109
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NEK11_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.057741 (rank : 473)
Query Neighborhood Hits	206	Target Neighborhood Hits	1043	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.057697 (rank : 474)
Query Neighborhood Hits	206	Target Neighborhood Hits	875	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK3_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.050076 (rank : 543)
Query Neighborhood Hits	206	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK4_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.050699 (rank : 528)
Query Neighborhood Hits	206	Target Neighborhood Hits	899	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.051894 (rank : 522)
Query Neighborhood Hits	206	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.052043 (rank : 520)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.052678 (rank : 510)
Query Neighborhood Hits	206	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.052648 (rank : 511)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NGEF_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.063367 (rank : 458)
Query Neighborhood Hits	206	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.064425 (rank : 455)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NTRK1_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.094254 (rank : 251)
Query Neighborhood Hits	206	Target Neighborhood Hits	1023	Shared Neighborhood Hits	40
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.088289 (rank : 321)
Query Neighborhood Hits	206	Target Neighborhood Hits	1081	Shared Neighborhood Hits	40
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.088290 (rank : 320)
Query Neighborhood Hits	206	Target Neighborhood Hits	1088	Shared Neighborhood Hits	40
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.091818 (rank : 280)
Query Neighborhood Hits	206	Target Neighborhood Hits	1115	Shared Neighborhood Hits	40
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

OXSR1_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.055237 (rank : 486)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.055668 (rank : 480)
Query Neighborhood Hits	206	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

P55G_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.112859 (rank : 193)
Query Neighborhood Hits	206	Target Neighborhood Hits	451	Shared Neighborhood Hits	60
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.109770 (rank : 201)
Query Neighborhood Hits	206	Target Neighborhood Hits	401	Shared Neighborhood Hits	58
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.110134 (rank : 200)
Query Neighborhood Hits	206	Target Neighborhood Hits	479	Shared Neighborhood Hits	78
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.112700 (rank : 194)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.111241 (rank : 197)
Query Neighborhood Hits	206	Target Neighborhood Hits	543	Shared Neighborhood Hits	68
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.112904 (rank : 192)
Query Neighborhood Hits	206	Target Neighborhood Hits	519	Shared Neighborhood Hits	68
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.208877 (rank : 77)
Query Neighborhood Hits	206	Target Neighborhood Hits	320	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.203465 (rank : 83)
Query Neighborhood Hits	206	Target Neighborhood Hits	283	Shared Neighborhood Hits	117
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.211375 (rank : 75)
Query Neighborhood Hits	206	Target Neighborhood Hits	339	Shared Neighborhood Hits	122
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.217981 (rank : 70)
Query Neighborhood Hits	206	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PEX13_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.115843 (rank : 188)
Query Neighborhood Hits	206	Target Neighborhood Hits	128	Shared Neighborhood Hits	72
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.113884 (rank : 191)
Query Neighborhood Hits	206	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PGFRA_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.091280 (rank : 288)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	40
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.091615 (rank : 285)
Query Neighborhood Hits	206	Target Neighborhood Hits	975	Shared Neighborhood Hits	40
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.091717 (rank : 283)
Query Neighborhood Hits	206	Target Neighborhood Hits	962	Shared Neighborhood Hits	40
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.091658 (rank : 284)
Query Neighborhood Hits	206	Target Neighborhood Hits	960	Shared Neighborhood Hits	40
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PKHG1_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.050993 (rank : 525)
Query Neighborhood Hits	206	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG1_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.186300 (rank : 111)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	117
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.190626 (rank : 104)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	121
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PRP4B_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.050173 (rank : 542)
Query Neighborhood Hits	206	Target Neighborhood Hits	1030	Shared Neighborhood Hits	45
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PTK6_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.150351 (rank : 148)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	119
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK7_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.083881 (rank : 347)
Query Neighborhood Hits	206	Target Neighborhood Hits	1103	Shared Neighborhood Hits	40
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PTN11_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.079955 (rank : 373)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.079966 (rank : 372)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.065500 (rank : 442)
Query Neighborhood Hits	206	Target Neighborhood Hits	234	Shared Neighborhood Hits	52
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.066309 (rank : 439)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RAF1_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.080768 (rank : 365)
Query Neighborhood Hits	206	Target Neighborhood Hits	886	Shared Neighborhood Hits	47
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.080264 (rank : 370)
Query Neighborhood Hits	206	Target Neighborhood Hits	886	Shared Neighborhood Hits	48
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RASA1_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.144088 (rank : 156)
Query Neighborhood Hits	206	Target Neighborhood Hits	258	Shared Neighborhood Hits	60
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RET_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.091076 (rank : 290)
Query Neighborhood Hits	206	Target Neighborhood Hits	873	Shared Neighborhood Hits	40
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.090445 (rank : 298)
Query Neighborhood Hits	206	Target Neighborhood Hits	884	Shared Neighborhood Hits	41
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RHG04_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.130208 (rank : 168)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.081130 (rank : 361)
Query Neighborhood Hits	206	Target Neighborhood Hits	281	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.077377 (rank : 385)
Query Neighborhood Hits	206	Target Neighborhood Hits	1479	Shared Neighborhood Hits	106
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.108541 (rank : 203)
Query Neighborhood Hits	206	Target Neighborhood Hits	263	Shared Neighborhood Hits	82
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.103347 (rank : 216)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIPK1_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.075615 (rank : 396)
Query Neighborhood Hits	206	Target Neighborhood Hits	891	Shared Neighborhood Hits	40
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.076945 (rank : 387)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.073324 (rank : 409)
Query Neighborhood Hits	206	Target Neighborhood Hits	774	Shared Neighborhood Hits	40
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.073412 (rank : 407)
Query Neighborhood Hits	206	Target Neighborhood Hits	776	Shared Neighborhood Hits	40
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.072057 (rank : 416)
Query Neighborhood Hits	206	Target Neighborhood Hits	828	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.073373 (rank : 408)
Query Neighborhood Hits	206	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.064475 (rank : 454)
Query Neighborhood Hits	206	Target Neighborhood Hits	1094	Shared Neighborhood Hits	52
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.064954 (rank : 448)
Query Neighborhood Hits	206	Target Neighborhood Hits	864	Shared Neighborhood Hits	41
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.064746 (rank : 450)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.092385 (rank : 267)
Query Neighborhood Hits	206	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.093625 (rank : 259)
Query Neighborhood Hits	206	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.089316 (rank : 307)
Query Neighborhood Hits	206	Target Neighborhood Hits	1018	Shared Neighborhood Hits	40
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.089587 (rank : 305)
Query Neighborhood Hits	206	Target Neighborhood Hits	1025	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.090837 (rank : 294)
Query Neighborhood Hits	206	Target Neighborhood Hits	1014	Shared Neighborhood Hits	40
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.092826 (rank : 264)
Query Neighborhood Hits	206	Target Neighborhood Hits	1000	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.099171 (rank : 231)
Query Neighborhood Hits	206	Target Neighborhood Hits	907	Shared Neighborhood Hits	39
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUSC1_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.103978 (rank : 214)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.053741 (rank : 496)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	57
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.101230 (rank : 220)
Query Neighborhood Hits	206	Target Neighborhood Hits	701	Shared Neighborhood Hits	40
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.100372 (rank : 225)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SBK1_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.050307 (rank : 534)
Query Neighborhood Hits	206	Target Neighborhood Hits	824	Shared Neighborhood Hits	41
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SH21A_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.125848 (rank : 175)
Query Neighborhood Hits	206	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.132949 (rank : 166)
Query Neighborhood Hits	206	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.149793 (rank : 149)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.161397 (rank : 142)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.055241 (rank : 485)
Query Neighborhood Hits	206	Target Neighborhood Hits	144	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.067438 (rank : 433)
Query Neighborhood Hits	206	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.076959 (rank : 386)
Query Neighborhood Hits	206	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH2D3_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.064602 (rank : 451)
Query Neighborhood Hits	206	Target Neighborhood Hits	188	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.070362 (rank : 420)
Query Neighborhood Hits	206	Target Neighborhood Hits	174	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHAN2_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.081510 (rank : 359)
Query Neighborhood Hits	206	Target Neighborhood Hits	446	Shared Neighborhood Hits	85
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.100168 (rank : 226)
Query Neighborhood Hits	206	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.102416 (rank : 218)
Query Neighborhood Hits	206	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.095675 (rank : 239)
Query Neighborhood Hits	206	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.095083 (rank : 242)
Query Neighborhood Hits	206	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.093884 (rank : 256)
Query Neighborhood Hits	206	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.089737 (rank : 304)
Query Neighborhood Hits	206	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.087672 (rank : 324)
Query Neighborhood Hits	206	Target Neighborhood Hits	155	Shared Neighborhood Hits	43
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.092173 (rank : 269)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	48
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.092000 (rank : 273)
Query Neighborhood Hits	206	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.091580 (rank : 286)
Query Neighborhood Hits	206	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.103633 (rank : 215)
Query Neighborhood Hits	206	Target Neighborhood Hits	164	Shared Neighborhood Hits	48
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.107656 (rank : 205)
Query Neighborhood Hits	206	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.126285 (rank : 172)
Query Neighborhood Hits	206	Target Neighborhood Hits	96	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.129729 (rank : 169)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SLAP2_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.259322 (rank : 45)
Query Neighborhood Hits	206	Target Neighborhood Hits	136	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SN1L2_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.050256 (rank : 538)
Query Neighborhood Hits	206	Target Neighborhood Hits	964	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.050022 (rank : 545)
Query Neighborhood Hits	206	Target Neighborhood Hits	944	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNX9_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.111797 (rank : 196)
Query Neighborhood Hits	206	Target Neighborhood Hits	148	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SOCS7_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.081447 (rank : 360)
Query Neighborhood Hits	206	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPN90_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.187531 (rank : 109)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.169548 (rank : 135)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRC8_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.206371 (rank : 79)
Query Neighborhood Hits	206	Target Neighborhood Hits	269	Shared Neighborhood Hits	122
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.201466 (rank : 86)
Query Neighborhood Hits	206	Target Neighborhood Hits	292	Shared Neighborhood Hits	123
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.104903 (rank : 210)
Query Neighborhood Hits	206	Target Neighborhood Hits	390	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.110219 (rank : 199)
Query Neighborhood Hits	206	Target Neighborhood Hits	331	Shared Neighborhood Hits	104
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.110589 (rank : 198)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	105
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.139580 (rank : 160)
Query Neighborhood Hits	206	Target Neighborhood Hits	946	Shared Neighborhood Hits	81
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

STAC_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.240729 (rank : 57)
Query Neighborhood Hits	206	Target Neighborhood Hits	268	Shared Neighborhood Hits	117
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STK16_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.050692 (rank : 529)
Query Neighborhood Hits	206	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.052235 (rank : 516)
Query Neighborhood Hits	206	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.053410 (rank : 502)
Query Neighborhood Hits	206	Target Neighborhood Hits	853	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.053853 (rank : 495)
Query Neighborhood Hits	206	Target Neighborhood Hits	856	Shared Neighborhood Hits	41
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.052646 (rank : 512)
Query Neighborhood Hits	206	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.052793 (rank : 509)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK39_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.055554 (rank : 481)
Query Neighborhood Hits	206	Target Neighborhood Hits	882	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.055465 (rank : 483)
Query Neighborhood Hits	206	Target Neighborhood Hits	915	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STS1_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.058515 (rank : 469)
Query Neighborhood Hits	206	Target Neighborhood Hits	106	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.058912 (rank : 468)
Query Neighborhood Hits	206	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.064961 (rank : 447)
Query Neighborhood Hits	206	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

STYK1_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.101091 (rank : 221)
Query Neighborhood Hits	206	Target Neighborhood Hits	786	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.100793 (rank : 223)
Query Neighborhood Hits	206	Target Neighborhood Hits	779	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAOK2_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.052824 (rank : 508)
Query Neighborhood Hits	206	Target Neighborhood Hits	1172	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.053687 (rank : 498)
Query Neighborhood Hits	206	Target Neighborhood Hits	1373	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TCGAP_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.053963 (rank : 494)
Query Neighborhood Hits	206	Target Neighborhood Hits	872	Shared Neighborhood Hits	90
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.062650 (rank : 459)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	78
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TENS4_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.057814 (rank : 471)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TESK1_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.065311 (rank : 444)
Query Neighborhood Hits	206	Target Neighborhood Hits	864	Shared Neighborhood Hits	43
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.065265 (rank : 445)
Query Neighborhood Hits	206	Target Neighborhood Hits	862	Shared Neighborhood Hits	42
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.066877 (rank : 436)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.066285 (rank : 440)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.093818 (rank : 257)
Query Neighborhood Hits	206	Target Neighborhood Hits	1103	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.093570 (rank : 260)
Query Neighborhood Hits	206	Target Neighborhood Hits	1333	Shared Neighborhood Hits	57
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.067031 (rank : 434)
Query Neighborhood Hits	206	Target Neighborhood Hits	755	Shared Neighborhood Hits	40
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.066945 (rank : 435)
Query Neighborhood Hits	206	Target Neighborhood Hits	753	Shared Neighborhood Hits	40
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.050458 (rank : 532)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.050501 (rank : 531)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TIAM1_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.050306 (rank : 535)
Query Neighborhood Hits	206	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIE1_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.085227 (rank : 336)
Query Neighborhood Hits	206	Target Neighborhood Hits	1241	Shared Neighborhood Hits	41
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.084945 (rank : 337)
Query Neighborhood Hits	206	Target Neighborhood Hits	1266	Shared Neighborhood Hits	42
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.084531 (rank : 341)
Query Neighborhood Hits	206	Target Neighborhood Hits	1192	Shared Neighborhood Hits	41
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.084612 (rank : 339)
Query Neighborhood Hits	206	Target Neighborhood Hits	1204	Shared Neighborhood Hits	41
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNI3K_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.070313 (rank : 421)
Query Neighborhood Hits	206	Target Neighborhood Hits	1084	Shared Neighborhood Hits	51
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.070512 (rank : 418)
Query Neighborhood Hits	206	Target Neighborhood Hits	1079	Shared Neighborhood Hits	51
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNK1_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.096072 (rank : 236)
Query Neighborhood Hits	206	Target Neighborhood Hits	815	Shared Neighborhood Hits	44
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.094586 (rank : 246)
Query Neighborhood Hits	206	Target Neighborhood Hits	806	Shared Neighborhood Hits	44
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.068967 (rank : 427)
Query Neighborhood Hits	206	Target Neighborhood Hits	605	Shared Neighborhood Hits	38
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.068981 (rank : 426)
Query Neighborhood Hits	206	Target Neighborhood Hits	618	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TTBK1_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.059620 (rank : 465)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	47
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.054750 (rank : 487)
Query Neighborhood Hits	206	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 585)	NC score	0.055723 (rank : 479)
Query Neighborhood Hits	206	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TYK2_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.081020 (rank : 362)
Query Neighborhood Hits	206	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.082160 (rank : 354)
Query Neighborhood Hits	206	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.088457 (rank : 318)
Query Neighborhood Hits	206	Target Neighborhood Hits	995	Shared Neighborhood Hits	39
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 589)	NC score	0.088864 (rank : 315)
Query Neighborhood Hits	206	Target Neighborhood Hits	1007	Shared Neighborhood Hits	41
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.092162 (rank : 271)
Query Neighborhood Hits	206	Target Neighborhood Hits	981	Shared Neighborhood Hits	43
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 591)	NC score	0.090564 (rank : 295)
Query Neighborhood Hits	206	Target Neighborhood Hits	988	Shared Neighborhood Hits	42
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

VAV_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.249102 (rank : 50)
Query Neighborhood Hits	206	Target Neighborhood Hits	452	Shared Neighborhood Hits	128
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.244948 (rank : 54)
Query Neighborhood Hits	206	Target Neighborhood Hits	430	Shared Neighborhood Hits	126
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VGFR1_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.079747 (rank : 376)
Query Neighborhood Hits	206	Target Neighborhood Hits	1109	Shared Neighborhood Hits	40
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.079470 (rank : 379)
Query Neighborhood Hits	206	Target Neighborhood Hits	1118	Shared Neighborhood Hits	40
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.081614 (rank : 357)
Query Neighborhood Hits	206	Target Neighborhood Hits	1103	Shared Neighborhood Hits	42
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.081670 (rank : 356)
Query Neighborhood Hits	206	Target Neighborhood Hits	1089	Shared Neighborhood Hits	41
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.084658 (rank : 338)
Query Neighborhood Hits	206	Target Neighborhood Hits	1037	Shared Neighborhood Hits	40
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 599)	NC score	0.084288 (rank : 342)
Query Neighborhood Hits	206	Target Neighborhood Hits	1056	Shared Neighborhood Hits	40
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WNK1_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.053149 (rank : 504)
Query Neighborhood Hits	206	Target Neighborhood Hits	1158	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.053736 (rank : 497)
Query Neighborhood Hits	206	Target Neighborhood Hits	1179	Shared Neighborhood Hits	54
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.054612 (rank : 488)
Query Neighborhood Hits	206	Target Neighborhood Hits	1407	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.053360 (rank : 503)
Query Neighborhood Hits	206	Target Neighborhood Hits	948	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

YSK4_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.052539 (rank : 513)
Query Neighborhood Hits	206	Target Neighborhood Hits	921	Shared Neighborhood Hits	40
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.104756 (rank : 211)
Query Neighborhood Hits	206	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.105938 (rank : 206)
Query Neighborhood Hits	206	Target Neighborhood Hits	905	Shared Neighborhood Hits	59
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

ES8L3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	206
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
NC score	0.969948 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	206	Target Neighborhood Hits	168	Shared Neighborhood Hits	126
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L2_MOUSE
NC score	0.890967 (rank : 3)	θ value	4.52582e-68 (rank : 3)
Query Neighborhood Hits	206	Target Neighborhood Hits	169	Shared Neighborhood Hits	109
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L1_HUMAN
NC score	0.884414 (rank : 4)	θ value	4.53632e-60 (rank : 8)
Query Neighborhood Hits	206	Target Neighborhood Hits	162	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
NC score	0.883097 (rank : 5)	θ value	3.03575e-64 (rank : 4)
Query Neighborhood Hits	206	Target Neighborhood Hits	193	Shared Neighborhood Hits	113
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L1_MOUSE
NC score	0.877954 (rank : 6)	θ value	1.41016e-61 (rank : 7)
Query Neighborhood Hits	206	Target Neighborhood Hits	143	Shared Neighborhood Hits	88
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

EPS8_MOUSE
NC score	0.871577 (rank : 7)	θ value	1.41016e-61 (rank : 6)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	105
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_HUMAN
NC score	0.866862 (rank : 8)	θ value	8.26713e-62 (rank : 5)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

NCK2_HUMAN
NC score	0.465238 (rank : 9)	θ value	7.59969e-07 (rank : 10)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	132
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.446714 (rank : 10)	θ value	1.43324e-05 (rank : 13)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	132
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP2_MOUSE
NC score	0.389069 (rank : 11)	θ value	0.0736092 (rank : 72)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	133
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.387865 (rank : 12)	θ value	0.0736092 (rank : 71)
Query Neighborhood Hits	206	Target Neighborhood Hits	304	Shared Neighborhood Hits	135
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRKL_MOUSE
NC score	0.383296 (rank : 13)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.382174 (rank : 14)	θ value	0.00298849 (rank : 44)
Query Neighborhood Hits	206	Target Neighborhood Hits	313	Shared Neighborhood Hits	132
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRAP_HUMAN
NC score	0.370816 (rank : 15)	θ value	0.0431538 (rank : 63)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	134
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.364031 (rank : 16)	θ value	0.0563607 (rank : 66)
Query Neighborhood Hits	206	Target Neighborhood Hits	309	Shared Neighborhood Hits	133
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PPIP1_HUMAN
NC score	0.363794 (rank : 17)	θ value	1.09739e-05 (rank : 12)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	128
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

NPHP1_MOUSE
NC score	0.362725 (rank : 18)	θ value	0.00298849 (rank : 45)
Query Neighborhood Hits	206	Target Neighborhood Hits	267	Shared Neighborhood Hits	121
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

GRB2_HUMAN
NC score	0.362641 (rank : 19)	θ value	0.62314 (rank : 115)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	134
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.361639 (rank : 20)	θ value	0.62314 (rank : 116)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	134
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NPHP1_HUMAN
NC score	0.351180 (rank : 21)	θ value	0.0961366 (rank : 76)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	118
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

STAM2_MOUSE
NC score	0.350667 (rank : 22)	θ value	0.00228821 (rank : 42)
Query Neighborhood Hits	206	Target Neighborhood Hits	285	Shared Neighborhood Hits	125
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PPIP1_MOUSE
NC score	0.341038 (rank : 23)	θ value	0.0563607 (rank : 67)
Query Neighborhood Hits	206	Target Neighborhood Hits	377	Shared Neighborhood Hits	129
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

STAM2_HUMAN
NC score	0.339469 (rank : 24)	θ value	0.00509761 (rank : 49)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	125
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

VINEX_MOUSE
NC score	0.338230 (rank : 25)	θ value	0.0193708 (rank : 53)
Query Neighborhood Hits	206	Target Neighborhood Hits	286	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

CRK_HUMAN
NC score	0.331756 (rank : 26)	θ value	0.47712 (rank : 107)
Query Neighborhood Hits	206	Target Neighborhood Hits	308	Shared Neighborhood Hits	130
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAM1_MOUSE
NC score	0.330389 (rank : 27)	θ value	0.0431538 (rank : 65)
Query Neighborhood Hits	206	Target Neighborhood Hits	273	Shared Neighborhood Hits	126
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF2_HUMAN
NC score	0.329080 (rank : 28)	θ value	0.0148317 (rank : 51)
Query Neighborhood Hits	206	Target Neighborhood Hits	229	Shared Neighborhood Hits	109
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CRK_MOUSE
NC score	0.328701 (rank : 29)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	130
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAM1_HUMAN
NC score	0.323308 (rank : 30)	θ value	0.0330416 (rank : 62)
Query Neighborhood Hits	206	Target Neighborhood Hits	271	Shared Neighborhood Hits	127
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

VINEX_HUMAN
NC score	0.320067 (rank : 31)	θ value	0.00509761 (rank : 50)
Query Neighborhood Hits	206	Target Neighborhood Hits	270	Shared Neighborhood Hits	122
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

DNMBP_HUMAN
NC score	0.319026 (rank : 32)	θ value	0.00020696 (rank : 20)
Query Neighborhood Hits	206	Target Neighborhood Hits	413	Shared Neighborhood Hits	135
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCF1_HUMAN
NC score	0.307298 (rank : 33)	θ value	0.21417 (rank : 92)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	114
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

DNMBP_MOUSE
NC score	0.304012 (rank : 34)	θ value	0.000121331 (rank : 17)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	135
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCF1_MOUSE
NC score	0.295583 (rank : 35)	θ value	0.163984 (rank : 85)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_MOUSE
NC score	0.278735 (rank : 36)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	206	Target Neighborhood Hits	336	Shared Neighborhood Hits	125
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SRBS1_MOUSE
NC score	0.272487 (rank : 37)	θ value	0.0961366 (rank : 79)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	124
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3K1_MOUSE
NC score	0.271727 (rank : 38)	θ value	0.0961366 (rank : 78)
Query Neighborhood Hits	206	Target Neighborhood Hits	332	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STAC_HUMAN
NC score	0.271630 (rank : 39)	θ value	0.0193708 (rank : 52)
Query Neighborhood Hits	206	Target Neighborhood Hits	276	Shared Neighborhood Hits	120
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRBS1_HUMAN
NC score	0.267119 (rank : 40)	θ value	0.279714 (rank : 100)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	122
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3K1_HUMAN
NC score	0.265475 (rank : 41)	θ value	0.62314 (rank : 118)
Query Neighborhood Hits	206	Target Neighborhood Hits	341	Shared Neighborhood Hits	118
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SLAP2_HUMAN
NC score	0.265054 (rank : 42)	θ value	1.38821 (rank : 139)
Query Neighborhood Hits	206	Target Neighborhood Hits	139	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

CD2AP_HUMAN
NC score	0.264958 (rank : 43)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	206	Target Neighborhood Hits	315	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

STAC3_HUMAN
NC score	0.260590 (rank : 44)	θ value	0.163984 (rank : 87)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	112
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SLAP2_MOUSE
NC score	0.259322 (rank : 45)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	206	Target Neighborhood Hits	136	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

STAC3_MOUSE
NC score	0.259106 (rank : 46)	θ value	0.365318 (rank : 103)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SLAP1_HUMAN
NC score	0.255532 (rank : 47)	θ value	2.36792 (rank : 152)
Query Neighborhood Hits	206	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SH3G3_MOUSE
NC score	0.255269 (rank : 48)	θ value	0.0961366 (rank : 77)
Query Neighborhood Hits	206	Target Neighborhood Hits	236	Shared Neighborhood Hits	119
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SLAP1_MOUSE
NC score	0.251258 (rank : 49)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	206	Target Neighborhood Hits	117	Shared Neighborhood Hits	49
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

VAV_HUMAN
NC score	0.249102 (rank : 50)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	206	Target Neighborhood Hits	452	Shared Neighborhood Hits	128
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

AHI1_HUMAN
NC score	0.247445 (rank : 51)	θ value	0.813845 (rank : 122)
Query Neighborhood Hits	206	Target Neighborhood Hits	537	Shared Neighborhood Hits	130
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

OSTF1_HUMAN
NC score	0.246035 (rank : 52)	θ value	0.00134147 (rank : 39)
Query Neighborhood Hits	206	Target Neighborhood Hits	466	Shared Neighborhood Hits	122
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ARHG7_MOUSE
NC score	0.245571 (rank : 53)	θ value	0.813845 (rank : 124)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	127
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV_MOUSE
NC score	0.244948 (rank : 54)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	206	Target Neighborhood Hits	430	Shared Neighborhood Hits	126
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SH3G2_HUMAN
NC score	0.241904 (rank : 55)	θ value	0.125558 (rank : 81)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	122
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

AHI1_MOUSE
NC score	0.241230 (rank : 56)	θ value	0.813845 (rank : 123)
Query Neighborhood Hits	206	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

STAC_MOUSE
NC score	0.240729 (rank : 57)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	206	Target Neighborhood Hits	268	Shared Neighborhood Hits	117
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG6_MOUSE
NC score	0.240131 (rank : 58)	θ value	0.62314 (rank : 113)
Query Neighborhood Hits	206	Target Neighborhood Hits	394	Shared Neighborhood Hits	124
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SH3G2_MOUSE
NC score	0.239469 (rank : 59)	θ value	0.21417 (rank : 94)
Query Neighborhood Hits	206	Target Neighborhood Hits	319	Shared Neighborhood Hits	119
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
NC score	0.237435 (rank : 60)	θ value	1.81305 (rank : 143)
Query Neighborhood Hits	206	Target Neighborhood Hits	222	Shared Neighborhood Hits	113
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_HUMAN
NC score	0.234708 (rank : 61)	θ value	0.279714 (rank : 99)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	115
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
NC score	0.234562 (rank : 62)	θ value	0.47712 (rank : 111)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	118
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

OSTF1_MOUSE
NC score	0.233574 (rank : 63)	θ value	0.00298849 (rank : 46)
Query Neighborhood Hits	206	Target Neighborhood Hits	467	Shared Neighborhood Hits	122
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ARHG7_HUMAN
NC score	0.230285 (rank : 64)	θ value	1.38821 (rank : 132)
Query Neighborhood Hits	206	Target Neighborhood Hits	347	Shared Neighborhood Hits	124
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ITSN2_HUMAN
NC score	0.230032 (rank : 65)	θ value	0.000786445 (rank : 33)
Query Neighborhood Hits	206	Target Neighborhood Hits	1173	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV3_HUMAN
NC score	0.226934 (rank : 66)	θ value	0.0252991 (rank : 59)
Query Neighborhood Hits	206	Target Neighborhood Hits	398	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG6_HUMAN
NC score	0.220632 (rank : 67)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	206	Target Neighborhood Hits	376	Shared Neighborhood Hits	119
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ITSN1_MOUSE
NC score	0.219572 (rank : 68)	θ value	0.00102713 (rank : 35)
Query Neighborhood Hits	206	Target Neighborhood Hits	1669	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV3_MOUSE
NC score	0.218055 (rank : 69)	θ value	0.0252991 (rank : 60)
Query Neighborhood Hits	206	Target Neighborhood Hits	404	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PACN2_MOUSE
NC score	0.217981 (rank : 70)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	206	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ITSN2_MOUSE
NC score	0.217412 (rank : 71)	θ value	0.000602161 (rank : 30)
Query Neighborhood Hits	206	Target Neighborhood Hits	1371	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CIP4_HUMAN
NC score	0.217180 (rank : 72)	θ value	0.0961366 (rank : 73)
Query Neighborhood Hits	206	Target Neighborhood Hits	374	Shared Neighborhood Hits	72
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

VAV2_HUMAN
NC score	0.213253 (rank : 73)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	206	Target Neighborhood Hits	453	Shared Neighborhood Hits	128
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.213074 (rank : 74)	θ value	2.36792 (rank : 155)
Query Neighborhood Hits	206	Target Neighborhood Hits	456	Shared Neighborhood Hits	126
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PACN2_HUMAN
NC score	0.211375 (rank : 75)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	206	Target Neighborhood Hits	339	Shared Neighborhood Hits	122
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ITSN1_HUMAN
NC score	0.209985 (rank : 76)	θ value	0.0431538 (rank : 64)
Query Neighborhood Hits	206	Target Neighborhood Hits	1757	Shared Neighborhood Hits	145
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PACN1_HUMAN
NC score	0.208877 (rank : 77)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	206	Target Neighborhood Hits	320	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EFS_MOUSE
NC score	0.206547 (rank : 78)	θ value	2.36792 (rank : 150)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	109
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SRC8_HUMAN
NC score	0.206371 (rank : 79)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	206	Target Neighborhood Hits	269	Shared Neighborhood Hits	122
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PACN3_HUMAN
NC score	0.204823 (rank : 80)	θ value	0.279714 (rank : 98)
Query Neighborhood Hits	206	Target Neighborhood Hits	385	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SNX18_MOUSE
NC score	0.204783 (rank : 81)	θ value	0.47712 (rank : 112)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	92
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ABI2_MOUSE
NC score	0.204212 (rank : 82)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	206	Target Neighborhood Hits	266	Shared Neighborhood Hits	114
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PACN1_MOUSE
NC score	0.203465 (rank : 83)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	206	Target Neighborhood Hits	283	Shared Neighborhood Hits	117
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ABI2_HUMAN
NC score	0.203035 (rank : 84)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	206	Target Neighborhood Hits	350	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

PLCG2_HUMAN
NC score	0.202898 (rank : 85)	θ value	0.813845 (rank : 127)
Query Neighborhood Hits	206	Target Neighborhood Hits	280	Shared Neighborhood Hits	121
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SRC8_MOUSE
NC score	0.201466 (rank : 86)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	206	Target Neighborhood Hits	292	Shared Neighborhood Hits	123
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PACN3_MOUSE
NC score	0.200879 (rank : 87)	θ value	1.38821 (rank : 138)
Query Neighborhood Hits	206	Target Neighborhood Hits	380	Shared Neighborhood Hits	114
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SNX18_HUMAN
NC score	0.199518 (rank : 88)	θ value	0.125558 (rank : 82)
Query Neighborhood Hits	206	Target Neighborhood Hits	207	Shared Neighborhood Hits	92
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

HCLS1_MOUSE
NC score	0.199380 (rank : 89)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	206	Target Neighborhood Hits	329	Shared Neighborhood Hits	118
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI3_MOUSE
NC score	0.197562 (rank : 90)	θ value	2.36792 (rank : 146)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BTK_HUMAN
NC score	0.196107 (rank : 91)	θ value	3.19293e-05 (rank : 15)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	131
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.196043 (rank : 92)	θ value	2.44474e-05 (rank : 14)
Query Neighborhood Hits	206	Target Neighborhood Hits	1017	Shared Neighborhood Hits	128
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

HCLS1_HUMAN
NC score	0.195835 (rank : 93)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	206	Target Neighborhood Hits	358	Shared Neighborhood Hits	117
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

BLK_MOUSE
NC score	0.194890 (rank : 94)	θ value	1.99992e-07 (rank : 9)
Query Neighborhood Hits	206	Target Neighborhood Hits	992	Shared Neighborhood Hits	111
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ABI3_HUMAN
NC score	0.194542 (rank : 95)	θ value	3.0926 (rank : 157)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NOXO1_MOUSE
NC score	0.192952 (rank : 96)	θ value	0.163984 (rank : 86)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	69
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

YES_MOUSE
NC score	0.192879 (rank : 97)	θ value	0.000158464 (rank : 19)
Query Neighborhood Hits	206	Target Neighborhood Hits	1052	Shared Neighborhood Hits	131
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.192822 (rank : 98)	θ value	9.29e-05 (rank : 16)
Query Neighborhood Hits	206	Target Neighborhood Hits	1069	Shared Neighborhood Hits	133
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_MOUSE
NC score	0.192605 (rank : 99)	θ value	0.000270298 (rank : 23)
Query Neighborhood Hits	206	Target Neighborhood Hits	1073	Shared Neighborhood Hits	135
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

YES_HUMAN
NC score	0.192143 (rank : 100)	θ value	0.000270298 (rank : 25)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	129
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SPTA1_MOUSE
NC score	0.191814 (rank : 101)	θ value	0.00134147 (rank : 40)
Query Neighborhood Hits	206	Target Neighborhood Hits	675	Shared Neighborhood Hits	122
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

BLK_HUMAN
NC score	0.191594 (rank : 102)	θ value	3.77169e-06 (rank : 11)
Query Neighborhood Hits	206	Target Neighborhood Hits	994	Shared Neighborhood Hits	115
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_HUMAN
NC score	0.190711 (rank : 103)	θ value	0.00020696 (rank : 21)
Query Neighborhood Hits	206	Target Neighborhood Hits	1035	Shared Neighborhood Hits	129
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

PLCG1_MOUSE
NC score	0.190626 (rank : 104)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	121
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

EFS_HUMAN
NC score	0.190418 (rank : 105)	θ value	1.81305 (rank : 140)
Query Neighborhood Hits	206	Target Neighborhood Hits	348	Shared Neighborhood Hits	110
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SRC_HUMAN
NC score	0.189919 (rank : 106)	θ value	0.000158464 (rank : 18)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	136
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_HUMAN
NC score	0.189724 (rank : 107)	θ value	0.000270298 (rank : 22)
Query Neighborhood Hits	206	Target Neighborhood Hits	1078	Shared Neighborhood Hits	135
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

HCK_MOUSE
NC score	0.189331 (rank : 108)	θ value	0.00134147 (rank : 38)
Query Neighborhood Hits	206	Target Neighborhood Hits	1029	Shared Neighborhood Hits	129
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SPN90_HUMAN
NC score	0.187531 (rank : 109)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ANM2_HUMAN
NC score	0.187286 (rank : 110)	θ value	2.36792 (rank : 147)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	108
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PLCG1_HUMAN
NC score	0.186300 (rank : 111)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	117
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NCF4_MOUSE
NC score	0.186134 (rank : 112)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	206	Target Neighborhood Hits	177	Shared Neighborhood Hits	93
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

FGR_HUMAN
NC score	0.185685 (rank : 113)	θ value	0.00035302 (rank : 26)
Query Neighborhood Hits	206	Target Neighborhood Hits	1067	Shared Neighborhood Hits	129
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

DBNL_HUMAN
NC score	0.184662 (rank : 114)	θ value	0.62314 (rank : 114)
Query Neighborhood Hits	206	Target Neighborhood Hits	244	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SRC_MOUSE
NC score	0.183999 (rank : 115)	θ value	0.000270298 (rank : 24)
Query Neighborhood Hits	206	Target Neighborhood Hits	1033	Shared Neighborhood Hits	125
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ABI1_MOUSE
NC score	0.181740 (rank : 116)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	110
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ANM2_MOUSE
NC score	0.181585 (rank : 117)	θ value	1.38821 (rank : 131)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ASPP1_HUMAN
NC score	0.178652 (rank : 118)	θ value	0.0736092 (rank : 68)
Query Neighborhood Hits	206	Target Neighborhood Hits	956	Shared Neighborhood Hits	115
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DBNL_MOUSE
NC score	0.178205 (rank : 119)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	206	Target Neighborhood Hits	306	Shared Neighborhood Hits	110
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

BCAR1_MOUSE
NC score	0.176485 (rank : 120)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	206	Target Neighborhood Hits	438	Shared Neighborhood Hits	130
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ITK_HUMAN
NC score	0.175572 (rank : 121)	θ value	0.00035302 (rank : 27)
Query Neighborhood Hits	206	Target Neighborhood Hits	1016	Shared Neighborhood Hits	116
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

BCAR1_HUMAN
NC score	0.175529 (rank : 122)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	206	Target Neighborhood Hits	554	Shared Neighborhood Hits	130
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NOXO1_HUMAN
NC score	0.174852 (rank : 123)	θ value	0.21417 (rank : 93)
Query Neighborhood Hits	206	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

TEC_HUMAN
NC score	0.173598 (rank : 124)	θ value	0.00134147 (rank : 41)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	119
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LYN_MOUSE
NC score	0.173460 (rank : 125)	θ value	0.00035302 (rank : 29)
Query Neighborhood Hits	206	Target Neighborhood Hits	1023	Shared Neighborhood Hits	119
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.172875 (rank : 126)	θ value	0.000602161 (rank : 31)
Query Neighborhood Hits	206	Target Neighborhood Hits	1022	Shared Neighborhood Hits	120
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TEC_MOUSE
NC score	0.172810 (rank : 127)	θ value	0.00102713 (rank : 36)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	117
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ABI1_HUMAN
NC score	0.172586 (rank : 128)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	206	Target Neighborhood Hits	257	Shared Neighborhood Hits	107
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

TXK_MOUSE
NC score	0.172447 (rank : 129)	θ value	0.00228821 (rank : 43)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	112
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LCK_HUMAN
NC score	0.171698 (rank : 130)	θ value	0.0961366 (rank : 75)
Query Neighborhood Hits	206	Target Neighborhood Hits	987	Shared Neighborhood Hits	101
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SPTA2_HUMAN
NC score	0.170221 (rank : 131)	θ value	0.00509761 (rank : 48)
Query Neighborhood Hits	206	Target Neighborhood Hits	888	Shared Neighborhood Hits	128
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

LCK_MOUSE
NC score	0.170114 (rank : 132)	θ value	0.125558 (rank : 80)
Query Neighborhood Hits	206	Target Neighborhood Hits	981	Shared Neighborhood Hits	101
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LASP1_HUMAN
NC score	0.169811 (rank : 133)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	108
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.169565 (rank : 134)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	108
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SPN90_MOUSE
NC score	0.169548 (rank : 135)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ASPP1_MOUSE
NC score	0.169279 (rank : 136)	θ value	0.163984 (rank : 83)
Query Neighborhood Hits	206	Target Neighborhood Hits	1244	Shared Neighborhood Hits	122
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

TXK_HUMAN
NC score	0.169069 (rank : 137)	θ value	0.000602161 (rank : 32)
Query Neighborhood Hits	206	Target Neighborhood Hits	971	Shared Neighborhood Hits	106
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

NCF4_HUMAN
NC score	0.167936 (rank : 138)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	206	Target Neighborhood Hits	161	Shared Neighborhood Hits	84
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SPTA1_HUMAN
NC score	0.167809 (rank : 139)	θ value	0.00390308 (rank : 47)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	123
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ITK_MOUSE
NC score	0.166993 (rank : 140)	θ value	0.00035302 (rank : 28)
Query Neighborhood Hits	206	Target Neighborhood Hits	985	Shared Neighborhood Hits	105
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

FRK_HUMAN
NC score	0.166656 (rank : 141)	θ value	0.0736092 (rank : 69)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	129
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

SH21B_MOUSE
NC score	0.161397 (rank : 142)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

IASPP_HUMAN
NC score	0.160262 (rank : 143)	θ value	1.38821 (rank : 135)
Query Neighborhood Hits	206	Target Neighborhood Hits	688	Shared Neighborhood Hits	121
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PTK6_MOUSE
NC score	0.155674 (rank : 144)	θ value	0.62314 (rank : 117)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	121
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ABL2_HUMAN
NC score	0.154914 (rank : 145)	θ value	0.0252991 (rank : 56)
Query Neighborhood Hits	206	Target Neighborhood Hits	1045	Shared Neighborhood Hits	108
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABL1_HUMAN
NC score	0.151404 (rank : 146)	θ value	0.0252991 (rank : 54)
Query Neighborhood Hits	206	Target Neighborhood Hits	1220	Shared Neighborhood Hits	114
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.151359 (rank : 147)	θ value	0.0252991 (rank : 55)
Query Neighborhood Hits	206	Target Neighborhood Hits	1178	Shared Neighborhood Hits	111
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

PTK6_HUMAN
NC score	0.150351 (rank : 148)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	119
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SH21B_HUMAN
NC score	0.149793 (rank : 149)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ARHG4_HUMAN
NC score	0.147183 (rank : 150)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	206	Target Neighborhood Hits	242	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CSK_HUMAN
NC score	0.146611 (rank : 151)	θ value	0.279714 (rank : 96)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	112
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.146580 (rank : 152)	θ value	0.279714 (rank : 97)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	112
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

IASPP_MOUSE
NC score	0.146333 (rank : 153)	θ value	1.38821 (rank : 136)
Query Neighborhood Hits	206	Target Neighborhood Hits	1024	Shared Neighborhood Hits	129
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SRMS_MOUSE
NC score	0.145068 (rank : 154)	θ value	0.0252991 (rank : 58)
Query Neighborhood Hits	206	Target Neighborhood Hits	964	Shared Neighborhood Hits	86
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SHLB2_MOUSE
NC score	0.144171 (rank : 155)	θ value	0.62314 (rank : 120)
Query Neighborhood Hits	206	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

RASA1_HUMAN
NC score	0.144088 (rank : 156)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	206	Target Neighborhood Hits	258	Shared Neighborhood Hits	60
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SHLB2_HUMAN
NC score	0.142801 (rank : 157)	θ value	0.62314 (rank : 119)
Query Neighborhood Hits	206	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

NEBL_HUMAN
NC score	0.141607 (rank : 158)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	206	Target Neighborhood Hits	457	Shared Neighborhood Hits	107
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RUSC1_HUMAN
NC score	0.140619 (rank : 159)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	206	Target Neighborhood Hits	226	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SRMS_HUMAN
NC score	0.139580 (rank : 160)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	206	Target Neighborhood Hits	946	Shared Neighborhood Hits	81
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

CASL_MOUSE
NC score	0.138380 (rank : 161)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	102
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CT032_HUMAN
NC score	0.138144 (rank : 162)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CASL_HUMAN
NC score	0.138000 (rank : 163)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	206	Target Neighborhood Hits	259	Shared Neighborhood Hits	98
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

M3KL4_HUMAN
NC score	0.136748 (rank : 164)	θ value	0.0330416 (rank : 61)
Query Neighborhood Hits	206	Target Neighborhood Hits	1087	Shared Neighborhood Hits	129
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

DAPP1_HUMAN
NC score	0.132978 (rank : 165)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SH21A_MOUSE
NC score	0.132949 (rank : 166)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	206	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

DAPP1_MOUSE
NC score	0.130351 (rank : 167)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RHG04_HUMAN
NC score	0.130208 (rank : 168)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SHLB1_MOUSE
NC score	0.129729 (rank : 169)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ARHG9_MOUSE
NC score	0.127457 (rank : 170)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	206	Target Neighborhood Hits	234	Shared Neighborhood Hits	101
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

SNX9_MOUSE
NC score	0.126864 (rank : 171)	θ value	0.62314 (rank : 121)
Query Neighborhood Hits	206	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SHLB1_HUMAN
NC score	0.126285 (rank : 172)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	206	Target Neighborhood Hits	96	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

NEBU_HUMAN
NC score	0.126274 (rank : 173)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	206	Target Neighborhood Hits	420	Shared Neighborhood Hits	109
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ARHG9_HUMAN
NC score	0.125898 (rank : 174)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	100
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SH21A_HUMAN
NC score	0.125848 (rank : 175)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	206	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

MYO1F_MOUSE
NC score	0.123691 (rank : 176)	θ value	0.365318 (rank : 102)
Query Neighborhood Hits	206	Target Neighborhood Hits	262	Shared Neighborhood Hits	123
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ASPP2_HUMAN
NC score	0.123640 (rank : 177)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	206	Target Neighborhood Hits	1156	Shared Neighborhood Hits	114
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

M3K10_HUMAN
NC score	0.122550 (rank : 178)	θ value	0.000786445 (rank : 34)
Query Neighborhood Hits	206	Target Neighborhood Hits	1071	Shared Neighborhood Hits	120
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

DDEF1_MOUSE
NC score	0.121942 (rank : 179)	θ value	1.38821 (rank : 133)
Query Neighborhood Hits	206	Target Neighborhood Hits	592	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO1F_HUMAN
NC score	0.120923 (rank : 180)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	206	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

BMX_MOUSE
NC score	0.120389 (rank : 181)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	206	Target Neighborhood Hits	912	Shared Neighborhood Hits	55
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.119680 (rank : 182)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	206	Target Neighborhood Hits	942	Shared Neighborhood Hits	55
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

M3K9_HUMAN
NC score	0.119503 (rank : 183)	θ value	0.813845 (rank : 125)
Query Neighborhood Hits	206	Target Neighborhood Hits	1123	Shared Neighborhood Hits	127
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

DDEF2_MOUSE
NC score	0.118248 (rank : 184)	θ value	0.21417 (rank : 88)
Query Neighborhood Hits	206	Target Neighborhood Hits	625	Shared Neighborhood Hits	98
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

MATK_MOUSE
NC score	0.118017 (rank : 185)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	206	Target Neighborhood Hits	952	Shared Neighborhood Hits	76
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MATK_HUMAN
NC score	0.117642 (rank : 186)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	206	Target Neighborhood Hits	954	Shared Neighborhood Hits	69
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

DDEF2_HUMAN
NC score	0.117319 (rank : 187)	θ value	0.163984 (rank : 84)
Query Neighborhood Hits	206	Target Neighborhood Hits	599	Shared Neighborhood Hits	93
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PEX13_HUMAN
NC score	0.115843 (rank : 188)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	206	Target Neighborhood Hits	128	Shared Neighborhood Hits	72
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

M3K11_HUMAN
NC score	0.115706 (rank : 189)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	206	Target Neighborhood Hits	1136	Shared Neighborhood Hits	122
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MYO1E_HUMAN
NC score	0.114127 (rank : 190)	θ value	0.0252991 (rank : 57)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	121
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PEX13_MOUSE
NC score	0.113884 (rank : 191)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	206	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

P85B_MOUSE
NC score	0.112904 (rank : 192)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	206	Target Neighborhood Hits	519	Shared Neighborhood Hits	68
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P55G_HUMAN
NC score	0.112859 (rank : 193)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	206	Target Neighborhood Hits	451	Shared Neighborhood Hits	60
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_MOUSE
NC score	0.112700 (rank : 194)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

FNBP2_HUMAN
NC score	0.112416 (rank : 195)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	206	Target Neighborhood Hits	432	Shared Neighborhood Hits	103
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SNX9_HUMAN
NC score	0.111797 (rank : 196)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	206	Target Neighborhood Hits	148	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

P85B_HUMAN
NC score	0.111241 (rank : 197)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	206	Target Neighborhood Hits	543	Shared Neighborhood Hits	68
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SRGP2_MOUSE
NC score	0.110589 (rank : 198)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	105
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.110219 (rank : 199)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	206	Target Neighborhood Hits	331	Shared Neighborhood Hits	104
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

P85A_HUMAN
NC score	0.110134 (rank : 200)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	206	Target Neighborhood Hits	479	Shared Neighborhood Hits	78
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P55G_MOUSE
NC score	0.109770 (rank : 201)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	206	Target Neighborhood Hits	401	Shared Neighborhood Hits	58
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

FER_HUMAN
NC score	0.108748 (rank : 202)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	206	Target Neighborhood Hits	1278	Shared Neighborhood Hits	69
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

RIMB2_HUMAN
NC score	0.108541 (rank : 203)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	206	Target Neighborhood Hits	263	Shared Neighborhood Hits	82
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

GRB14_MOUSE
NC score	0.108248 (rank : 204)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	206	Target Neighborhood Hits	149	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHE_MOUSE
NC score	0.107656 (rank : 205)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	206	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ZAP70_MOUSE
NC score	0.105938 (rank : 206)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	206	Target Neighborhood Hits	905	Shared Neighborhood Hits	59
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ARHG4_MOUSE
NC score	0.105744 (rank : 207)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	206	Target Neighborhood Hits	185	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ACK1_MOUSE
NC score	0.105446 (rank : 208)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	206	Target Neighborhood Hits	1080	Shared Neighborhood Hits	79
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACK1_HUMAN
NC score	0.105106 (rank : 209)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	206	Target Neighborhood Hits	1140	Shared Neighborhood Hits	76
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

SRGP1_HUMAN
NC score	0.104903 (rank : 210)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	206	Target Neighborhood Hits	390	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ZAP70_HUMAN
NC score	0.104756 (rank : 211)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	206	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

GRB14_HUMAN
NC score	0.104668 (rank : 212)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	206	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HSH2D_HUMAN
NC score	0.104309 (rank : 213)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	206	Target Neighborhood Hits	159	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

RUSC1_MOUSE
NC score	0.103978 (rank : 214)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SHE_HUMAN
NC score	0.103633 (rank : 215)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	206	Target Neighborhood Hits	164	Shared Neighborhood Hits	48
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

RIMB2_MOUSE
NC score	0.103347 (rank : 216)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

KSYK_MOUSE
NC score	0.102863 (rank : 217)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	206	Target Neighborhood Hits	944	Shared Neighborhood Hits	62
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SHB_MOUSE
NC score	0.102416 (rank : 218)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	206	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

KSYK_HUMAN
NC score	0.102129 (rank : 219)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	206	Target Neighborhood Hits	901	Shared Neighborhood Hits	59
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

RYK_HUMAN
NC score	0.101230 (rank : 220)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	206	Target Neighborhood Hits	701	Shared Neighborhood Hits	40
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

STYK1_HUMAN
NC score	0.101091 (rank : 221)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	206	Target Neighborhood Hits	786	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

LTK_HUMAN
NC score	0.100923 (rank : 222)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	206	Target Neighborhood Hits	774	Shared Neighborhood Hits	39
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

STYK1_MOUSE
NC score	0.100793 (rank : 223)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	206	Target Neighborhood Hits	779	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

LTK_MOUSE
NC score	0.100376 (rank : 224)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	206	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

RYK_MOUSE
NC score	0.100372 (rank : 225)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SHB_HUMAN
NC score	0.100168 (rank : 226)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	206	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

FES_HUMAN
NC score	0.100037 (rank : 227)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	206	Target Neighborhood Hits	978	Shared Neighborhood Hits	49
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ALK_MOUSE
NC score	0.099928 (rank : 228)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	206	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_HUMAN
NC score	0.099626 (rank : 229)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	206	Target Neighborhood Hits	795	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

FES_MOUSE
NC score	0.099243 (rank : 230)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ROS_HUMAN
NC score	0.099171 (rank : 231)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	206	Target Neighborhood Hits	907	Shared Neighborhood Hits	39
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

DDR1_MOUSE
NC score	0.097386 (rank : 232)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	206	Target Neighborhood Hits	818	Shared Neighborhood Hits	40
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.096848 (rank : 233)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	206	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

ERBB2_HUMAN
NC score	0.096632 (rank : 234)	θ value	5.27518 (rank : 179)
Query Neighborhood Hits	206	Target Neighborhood Hits	1073	Shared Neighborhood Hits	47
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

FAK2_HUMAN
NC score	0.096279 (rank : 235)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	41
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TNK1_HUMAN
NC score	0.096072 (rank : 236)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	206	Target Neighborhood Hits	815	Shared Neighborhood Hits	44
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

AATK_MOUSE
NC score	0.096068 (rank : 237)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	206	Target Neighborhood Hits	942	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

FAK2_MOUSE
NC score	0.095962 (rank : 238)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

SHC1_HUMAN
NC score	0.095675 (rank : 239)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	206	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

AATK_HUMAN
NC score	0.095632 (rank : 240)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	206	Target Neighborhood Hits	1243	Shared Neighborhood Hits	60
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ERBB2_MOUSE
NC score	0.095251 (rank : 241)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	206	Target Neighborhood Hits	918	Shared Neighborhood Hits	42
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

SHC1_MOUSE
NC score	0.095083 (rank : 242)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	206	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ERBB3_HUMAN
NC score	0.095052 (rank : 243)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	206	Target Neighborhood Hits	918	Shared Neighborhood Hits	40
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

EPHAA_HUMAN
NC score	0.094991 (rank : 244)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	206	Target Neighborhood Hits	960	Shared Neighborhood Hits	40
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

IGF1R_MOUSE
NC score	0.094607 (rank : 245)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	206	Target Neighborhood Hits	973	Shared Neighborhood Hits	41
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

TNK1_MOUSE
NC score	0.094586 (rank : 246)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	206	Target Neighborhood Hits	806	Shared Neighborhood Hits	44
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

EPHB6_HUMAN
NC score	0.094433 (rank : 247)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	206	Target Neighborhood Hits	912	Shared Neighborhood Hits	40
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

FLT3_MOUSE
NC score	0.094374 (rank : 248)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

IGF1R_HUMAN
NC score	0.094362 (rank : 249)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	206	Target Neighborhood Hits	977	Shared Neighborhood Hits	41
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ERBB3_MOUSE
NC score	0.094283 (rank : 250)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	206	Target Neighborhood Hits	898	Shared Neighborhood Hits	39
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

NTRK1_HUMAN
NC score	0.094254 (rank : 251)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	206	Target Neighborhood Hits	1023	Shared Neighborhood Hits	40
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

ERBB4_HUMAN
NC score	0.094097 (rank : 252)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	206	Target Neighborhood Hits	910	Shared Neighborhood Hits	42
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

INSRR_HUMAN
NC score	0.094046 (rank : 253)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	206	Target Neighborhood Hits	950	Shared Neighborhood Hits	42
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
NC score	0.093988 (rank : 254)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	206	Target Neighborhood Hits	961	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

FLT3_HUMAN
NC score	0.093918 (rank : 255)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	206	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

SHC2_HUMAN
NC score	0.093884 (rank : 256)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	206	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

TEX14_HUMAN
NC score	0.093818 (rank : 257)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	206	Target Neighborhood Hits	1103	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

MERTK_HUMAN
NC score	0.093633 (rank : 258)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	206	Target Neighborhood Hits	988	Shared Neighborhood Hits	39
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

RON_MOUSE
NC score	0.093625 (rank : 259)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	206	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TEX14_MOUSE
NC score	0.093570 (rank : 260)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	206	Target Neighborhood Hits	1333	Shared Neighborhood Hits	57
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

MERTK_MOUSE
NC score	0.093454 (rank : 261)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	206	Target Neighborhood Hits	974	Shared Neighborhood Hits	42
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

EPHB6_MOUSE
NC score	0.093349 (rank : 262)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	206	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

CSF1R_HUMAN
NC score	0.092883 (rank : 263)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	206	Target Neighborhood Hits	943	Shared Neighborhood Hits	40
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ROR2_MOUSE
NC score	0.092826 (rank : 264)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	206	Target Neighborhood Hits	1000	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

EPHA6_HUMAN
NC score	0.092819 (rank : 265)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	206	Target Neighborhood Hits	959	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
NC score	0.092722 (rank : 266)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	206	Target Neighborhood Hits	946	Shared Neighborhood Hits	41
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

RON_HUMAN
NC score	0.092385 (rank : 267)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	206	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

DDR2_HUMAN
NC score	0.092191 (rank : 268)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	206	Target Neighborhood Hits	818	Shared Neighborhood Hits	40
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

SHC3_MOUSE
NC score	0.092173 (rank : 269)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	48
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

DDR2_MOUSE
NC score	0.092170 (rank : 270)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	206	Target Neighborhood Hits	813	Shared Neighborhood Hits	40
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

UFO_HUMAN
NC score	0.092162 (rank : 271)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	206	Target Neighborhood Hits	981	Shared Neighborhood Hits	43
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

EPHA5_MOUSE
NC score	0.092129 (rank : 272)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	206	Target Neighborhood Hits	950	Shared Neighborhood Hits	40
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

SHD_HUMAN
NC score	0.092000 (rank : 273)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	206	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

INSR_HUMAN
NC score	0.091970 (rank : 274)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	206	Target Neighborhood Hits	963	Shared Neighborhood Hits	40
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EGFR_MOUSE
NC score	0.091893 (rank : 275)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	206	Target Neighborhood Hits	927	Shared Neighborhood Hits	40
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EGFR_HUMAN
NC score	0.091883 (rank : 276)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	206	Target Neighborhood Hits	939	Shared Neighborhood Hits	41
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

FAK1_MOUSE
NC score	0.091849 (rank : 277)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	206	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.091844 (rank : 278)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	206	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

APS_HUMAN
NC score	0.091820 (rank : 279)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	206	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

NTRK3_HUMAN
NC score	0.091818 (rank : 280)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	206	Target Neighborhood Hits	1115	Shared Neighborhood Hits	40
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

INSR_MOUSE
NC score	0.091804 (rank : 281)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	206	Target Neighborhood Hits	968	Shared Neighborhood Hits	40
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ILK_MOUSE
NC score	0.091771 (rank : 282)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	206	Target Neighborhood Hits	858	Shared Neighborhood Hits	49
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

PGFRB_HUMAN
NC score	0.091717 (rank : 283)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	206	Target Neighborhood Hits	962	Shared Neighborhood Hits	40
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
NC score	0.091658 (rank : 284)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	206	Target Neighborhood Hits	960	Shared Neighborhood Hits	40
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRA_MOUSE
NC score	0.091615 (rank : 285)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	206	Target Neighborhood Hits	975	Shared Neighborhood Hits	40
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

SHD_MOUSE
NC score	0.091580 (rank : 286)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	206	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

EPHA1_MOUSE
NC score	0.091401 (rank : 287)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	206	Target Neighborhood Hits	958	Shared Neighborhood Hits	41
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

PGFRA_HUMAN
NC score	0.091280 (rank : 288)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	40
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ILK1_HUMAN
NC score	0.091242 (rank : 289)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	206	Target Neighborhood Hits	857	Shared Neighborhood Hits	49
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

RET_HUMAN
NC score	0.091076 (rank : 290)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	206	Target Neighborhood Hits	873	Shared Neighborhood Hits	40
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

EPHA1_HUMAN
NC score	0.091042 (rank : 291)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	206	Target Neighborhood Hits	997	Shared Neighborhood Hits	42
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

KIT_MOUSE
NC score	0.090940 (rank : 292)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	206	Target Neighborhood Hits	949	Shared Neighborhood Hits	41
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MET_MOUSE
NC score	0.090939 (rank : 293)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	206	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

ROR2_HUMAN
NC score	0.090837 (rank : 294)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	206	Target Neighborhood Hits	1014	Shared Neighborhood Hits	40
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

UFO_MOUSE
NC score	0.090564 (rank : 295)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	206	Target Neighborhood Hits	988	Shared Neighborhood Hits	42
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ILK2_HUMAN
NC score	0.090521 (rank : 296)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	206	Target Neighborhood Hits	848	Shared Neighborhood Hits	49
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MET_HUMAN
NC score	0.090492 (rank : 297)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	206	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RET_MOUSE
NC score	0.090445 (rank : 298)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	206	Target Neighborhood Hits	884	Shared Neighborhood Hits	41
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

EPHA2_MOUSE
NC score	0.090390 (rank : 299)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	41
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA2_HUMAN
NC score	0.090250 (rank : 300)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	206	Target Neighborhood Hits	1021	Shared Neighborhood Hits	41
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

KIT_HUMAN
NC score	0.090151 (rank : 301)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	206	Target Neighborhood Hits	953	Shared Neighborhood Hits	40
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

CSF1R_MOUSE
NC score	0.089898 (rank : 302)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	206	Target Neighborhood Hits	983	Shared Neighborhood Hits	40
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHB4_HUMAN
NC score	0.089751 (rank : 303)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	206	Target Neighborhood Hits	1056	Shared Neighborhood Hits	41
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

SHC2_MOUSE
NC score	0.089737 (rank : 304)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	206	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

ROR1_MOUSE
NC score	0.089587 (rank : 305)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	206	Target Neighborhood Hits	1025	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

EPHB3_MOUSE
NC score	0.089322 (rank : 306)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	42
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

ROR1_HUMAN
NC score	0.089316 (rank : 307)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	206	Target Neighborhood Hits	1018	Shared Neighborhood Hits	40
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

EPHB4_MOUSE
NC score	0.089314 (rank : 308)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	206	Target Neighborhood Hits	1013	Shared Neighborhood Hits	41
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB3_HUMAN
NC score	0.089233 (rank : 309)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	42
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA8_MOUSE
NC score	0.089173 (rank : 310)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	206	Target Neighborhood Hits	969	Shared Neighborhood Hits	41
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHB2_MOUSE
NC score	0.089016 (rank : 311)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	206	Target Neighborhood Hits	982	Shared Neighborhood Hits	41
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA8_HUMAN
NC score	0.089008 (rank : 312)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	206	Target Neighborhood Hits	956	Shared Neighborhood Hits	40
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

FGFR4_MOUSE
NC score	0.088994 (rank : 313)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	40
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHB2_HUMAN
NC score	0.088986 (rank : 314)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	206	Target Neighborhood Hits	983	Shared Neighborhood Hits	41
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

TYRO3_MOUSE
NC score	0.088864 (rank : 315)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	206	Target Neighborhood Hits	1007	Shared Neighborhood Hits	41
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

EPHA4_HUMAN
NC score	0.088647 (rank : 316)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	206	Target Neighborhood Hits	975	Shared Neighborhood Hits	40
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.088606 (rank : 317)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	206	Target Neighborhood Hits	982	Shared Neighborhood Hits	40
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

TYRO3_HUMAN
NC score	0.088457 (rank : 318)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	206	Target Neighborhood Hits	995	Shared Neighborhood Hits	39
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHA5_HUMAN
NC score	0.088294 (rank : 319)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

NTRK2_MOUSE
NC score	0.088290 (rank : 320)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	206	Target Neighborhood Hits	1088	Shared Neighborhood Hits	40
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.088289 (rank : 321)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	206	Target Neighborhood Hits	1081	Shared Neighborhood Hits	40
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

EPHB1_HUMAN
NC score	0.087752 (rank : 322)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	206	Target Neighborhood Hits	988	Shared Neighborhood Hits	42
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

GRB7_MOUSE
NC score	0.087721 (rank : 323)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

SHC3_HUMAN
NC score	0.087672 (rank : 324)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	206	Target Neighborhood Hits	155	Shared Neighborhood Hits	43
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

EPHA3_MOUSE
NC score	0.087491 (rank : 325)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	41
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA3_HUMAN
NC score	0.087320 (rank : 326)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	206	Target Neighborhood Hits	1005	Shared Neighborhood Hits	41
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

FGFR4_HUMAN
NC score	0.087236 (rank : 327)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	206	Target Neighborhood Hits	1037	Shared Neighborhood Hits	40
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

MLKL_HUMAN
NC score	0.087139 (rank : 328)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	206	Target Neighborhood Hits	600	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

EPHA7_HUMAN
NC score	0.086838 (rank : 329)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	206	Target Neighborhood Hits	1053	Shared Neighborhood Hits	42
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
NC score	0.086776 (rank : 330)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	206	Target Neighborhood Hits	1025	Shared Neighborhood Hits	41
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

MUSK_MOUSE
NC score	0.086362 (rank : 331)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	206	Target Neighborhood Hits	1057	Shared Neighborhood Hits	40
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MUSK_HUMAN
NC score	0.086087 (rank : 332)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	206	Target Neighborhood Hits	1074	Shared Neighborhood Hits	40
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

GUC2F_HUMAN
NC score	0.085583 (rank : 333)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	206	Target Neighborhood Hits	740	Shared Neighborhood Hits	40
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

LNK_HUMAN
NC score	0.085413 (rank : 334)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MLKL_MOUSE
NC score	0.085230 (rank : 335)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	206	Target Neighborhood Hits	707	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

TIE1_HUMAN
NC score	0.085227 (rank : 336)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	206	Target Neighborhood Hits	1241	Shared Neighborhood Hits	41
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
NC score	0.084945 (rank : 337)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	206	Target Neighborhood Hits	1266	Shared Neighborhood Hits	42
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

VGFR3_HUMAN
NC score	0.084658 (rank : 338)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	206	Target Neighborhood Hits	1037	Shared Neighborhood Hits	40
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

TIE2_MOUSE
NC score	0.084612 (rank : 339)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	206	Target Neighborhood Hits	1204	Shared Neighborhood Hits	41
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

FGFR3_HUMAN
NC score	0.084604 (rank : 340)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	206	Target Neighborhood Hits	1042	Shared Neighborhood Hits	40
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

TIE2_HUMAN
NC score	0.084531 (rank : 341)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	206	Target Neighborhood Hits	1192	Shared Neighborhood Hits	41
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

VGFR3_MOUSE
NC score	0.084288 (rank : 342)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	206	Target Neighborhood Hits	1056	Shared Neighborhood Hits	40
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR3_MOUSE
NC score	0.084210 (rank : 343)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	40
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR2_MOUSE
NC score	0.084077 (rank : 344)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	206	Target Neighborhood Hits	1062	Shared Neighborhood Hits	40
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

ANPRA_MOUSE
NC score	0.084045 (rank : 345)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	206	Target Neighborhood Hits	600	Shared Neighborhood Hits	38
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.083944 (rank : 346)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	206	Target Neighborhood Hits	612	Shared Neighborhood Hits	38
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

PTK7_HUMAN
NC score	0.083881 (rank : 347)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	206	Target Neighborhood Hits	1103	Shared Neighborhood Hits	40
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

FGFR2_HUMAN
NC score	0.083670 (rank : 348)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	206	Target Neighborhood Hits	1062	Shared Neighborhood Hits	40
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR1_MOUSE
NC score	0.083505 (rank : 349)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	206	Target Neighborhood Hits	1068	Shared Neighborhood Hits	40
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.083499 (rank : 350)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	206	Target Neighborhood Hits	1069	Shared Neighborhood Hits	40
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

JAK1_HUMAN
NC score	0.083256 (rank : 351)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	206	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

IRAK3_MOUSE
NC score	0.083166 (rank : 352)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	206	Target Neighborhood Hits	628	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

JAK1_MOUSE
NC score	0.083152 (rank : 353)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	206	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

TYK2_MOUSE
NC score	0.082160 (rank : 354)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	206	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_HUMAN
NC score	0.081697 (rank : 355)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	206	Target Neighborhood Hits	827	Shared Neighborhood Hits	40
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

VGFR2_MOUSE
NC score	0.081670 (rank : 356)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	206	Target Neighborhood Hits	1089	Shared Neighborhood Hits	41
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR2_HUMAN
NC score	0.081614 (rank : 357)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	206	Target Neighborhood Hits	1103	Shared Neighborhood Hits	42
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

GUC2C_HUMAN
NC score	0.081613 (rank : 358)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	206	Target Neighborhood Hits	624	Shared Neighborhood Hits	38
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

SHAN2_MOUSE
NC score	0.081510 (rank : 359)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	206	Target Neighborhood Hits	446	Shared Neighborhood Hits	85
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SOCS7_MOUSE
NC score	0.081447 (rank : 360)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	206	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

RHG26_HUMAN
NC score	0.081130 (rank : 361)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	206	Target Neighborhood Hits	281	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

TYK2_HUMAN
NC score	0.081020 (rank : 362)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	206	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

LNK_MOUSE
NC score	0.080967 (rank : 363)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	206	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ARAF_MOUSE
NC score	0.080865 (rank : 364)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

RAF1_HUMAN
NC score	0.080768 (rank : 365)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	206	Target Neighborhood Hits	886	Shared Neighborhood Hits	47
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MLTK_HUMAN
NC score	0.080601 (rank : 366)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	206	Target Neighborhood Hits	911	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
NC score	0.080524 (rank : 367)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
NC score	0.080471 (rank : 368)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	206	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ANPRB_MOUSE
NC score	0.080285 (rank : 369)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	206	Target Neighborhood Hits	607	Shared Neighborhood Hits	39
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

RAF1_MOUSE
NC score	0.080264 (rank : 370)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	206	Target Neighborhood Hits	886	Shared Neighborhood Hits	48
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ARAF_HUMAN
NC score	0.080183 (rank : 371)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	206	Target Neighborhood Hits	924	Shared Neighborhood Hits	46
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

PTN11_MOUSE
NC score	0.079966 (rank : 372)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.079955 (rank : 373)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

MOS_MOUSE
NC score	0.079886 (rank : 374)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	41
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

BRAF1_HUMAN
NC score	0.079851 (rank : 375)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	206	Target Neighborhood Hits	883	Shared Neighborhood Hits	48
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

VGFR1_HUMAN
NC score	0.079747 (rank : 376)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	206	Target Neighborhood Hits	1109	Shared Neighborhood Hits	40
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ANPRB_HUMAN
NC score	0.079588 (rank : 377)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	206	Target Neighborhood Hits	646	Shared Neighborhood Hits	39
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2G_MOUSE
NC score	0.079497 (rank : 378)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	206	Target Neighborhood Hits	644	Shared Neighborhood Hits	38
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

VGFR1_MOUSE
NC score	0.079470 (rank : 379)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	206	Target Neighborhood Hits	1118	Shared Neighborhood Hits	40
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

IRAK3_HUMAN
NC score	0.079420 (rank : 380)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	206	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

JAK2_MOUSE
NC score	0.078806 (rank : 381)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	206	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_HUMAN
NC score	0.078542 (rank : 382)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_MOUSE
NC score	0.078535 (rank : 383)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	206	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

GRB7_HUMAN
NC score	0.078220 (rank : 384)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	206	Target Neighborhood Hits	156	Shared Neighborhood Hits	48
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

RIMB1_HUMAN
NC score	0.077377 (rank : 385)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	206	Target Neighborhood Hits	1479	Shared Neighborhood Hits	106
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SH24A_HUMAN
NC score	0.076959 (rank : 386)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	206	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

RIPK1_MOUSE
NC score	0.076945 (rank : 387)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIMB1_MOUSE
NC score	0.076682 (rank : 388)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	206	Target Neighborhood Hits	1376	Shared Neighborhood Hits	111
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

IRAK1_MOUSE
NC score	0.076672 (rank : 389)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	206	Target Neighborhood Hits	784	Shared Neighborhood Hits	40
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

GUC2D_HUMAN
NC score	0.076249 (rank : 390)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GRB10_MOUSE
NC score	0.076065 (rank : 391)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	206	Target Neighborhood Hits	156	Shared Neighborhood Hits	48
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

M3K13_HUMAN
NC score	0.075994 (rank : 392)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	206	Target Neighborhood Hits	911	Shared Neighborhood Hits	44
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

KSR2_HUMAN
NC score	0.075752 (rank : 393)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	206	Target Neighborhood Hits	920	Shared Neighborhood Hits	51
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

BMR1B_MOUSE
NC score	0.075684 (rank : 394)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	206	Target Neighborhood Hits	758	Shared Neighborhood Hits	40
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

LCP2_HUMAN
NC score	0.075671 (rank : 395)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	206	Target Neighborhood Hits	531	Shared Neighborhood Hits	57
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

RIPK1_HUMAN
NC score	0.075615 (rank : 396)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	206	Target Neighborhood Hits	891	Shared Neighborhood Hits	40
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

GUC2E_MOUSE
NC score	0.075595 (rank : 397)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	206	Target Neighborhood Hits	692	Shared Neighborhood Hits	39
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

BMR1B_HUMAN
NC score	0.075416 (rank : 398)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	206	Target Neighborhood Hits	760	Shared Neighborhood Hits	40
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

M3K12_HUMAN
NC score	0.075305 (rank : 399)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	206	Target Neighborhood Hits	940	Shared Neighborhood Hits	40
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

KSR1_HUMAN
NC score	0.075292 (rank : 400)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	206	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

M3K12_MOUSE
NC score	0.075239 (rank : 401)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	206	Target Neighborhood Hits	957	Shared Neighborhood Hits	40
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

IRAK2_HUMAN
NC score	0.075231 (rank : 402)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	206	Target Neighborhood Hits	714	Shared Neighborhood Hits	42
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

SHAN1_HUMAN
NC score	0.075043 (rank : 403)	θ value	1.81305 (rank : 144)
Query Neighborhood Hits	206	Target Neighborhood Hits	1041	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

LCP2_MOUSE
NC score	0.074947 (rank : 404)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	206	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

KSR1_MOUSE
NC score	0.074086 (rank : 405)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	206	Target Neighborhood Hits	870	Shared Neighborhood Hits	43
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

GRB10_HUMAN
NC score	0.073472 (rank : 406)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	206	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

RIPK2_MOUSE
NC score	0.073412 (rank : 407)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	206	Target Neighborhood Hits	776	Shared Neighborhood Hits	40
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_MOUSE
NC score	0.073373 (rank : 408)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	206	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK2_HUMAN
NC score	0.073324 (rank : 409)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	206	Target Neighborhood Hits	774	Shared Neighborhood Hits	40
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

M3K7_MOUSE
NC score	0.073284 (rank : 410)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	206	Target Neighborhood Hits	892	Shared Neighborhood Hits	40
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.073262 (rank : 411)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	206	Target Neighborhood Hits	892	Shared Neighborhood Hits	40
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

IRAK1_HUMAN
NC score	0.073226 (rank : 412)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	206	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

BMR1A_MOUSE
NC score	0.073021 (rank : 413)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	206	Target Neighborhood Hits	758	Shared Neighborhood Hits	40
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1A_HUMAN
NC score	0.072858 (rank : 414)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	206	Target Neighborhood Hits	759	Shared Neighborhood Hits	40
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

ARHG5_HUMAN
NC score	0.072199 (rank : 415)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	206	Target Neighborhood Hits	172	Shared Neighborhood Hits	56
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RIPK3_HUMAN
NC score	0.072057 (rank : 416)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	206	Target Neighborhood Hits	828	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

IRAK4_HUMAN
NC score	0.071786 (rank : 417)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	206	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

TNI3K_MOUSE
NC score	0.070512 (rank : 418)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	206	Target Neighborhood Hits	1079	Shared Neighborhood Hits	51
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TRIO_HUMAN
NC score	0.070449 (rank : 419)	θ value	2.36792 (rank : 153)
Query Neighborhood Hits	206	Target Neighborhood Hits	1580	Shared Neighborhood Hits	82
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SH2D3_MOUSE
NC score	0.070362 (rank : 420)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	206	Target Neighborhood Hits	174	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

TNI3K_HUMAN
NC score	0.070313 (rank : 421)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	206	Target Neighborhood Hits	1084	Shared Neighborhood Hits	51
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ACVL1_HUMAN
NC score	0.069856 (rank : 422)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	206	Target Neighborhood Hits	716	Shared Neighborhood Hits	39
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
NC score	0.069850 (rank : 423)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	206	Target Neighborhood Hits	739	Shared Neighborhood Hits	39
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

AMPH_HUMAN
NC score	0.069392 (rank : 424)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	206	Target Neighborhood Hits	455	Shared Neighborhood Hits	61
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

IRAK4_MOUSE
NC score	0.069114 (rank : 425)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	206	Target Neighborhood Hits	820	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

TOPK_MOUSE
NC score	0.068981 (rank : 426)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	206	Target Neighborhood Hits	618	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TOPK_HUMAN
NC score	0.068967 (rank : 427)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	206	Target Neighborhood Hits	605	Shared Neighborhood Hits	38
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

LIMK1_HUMAN
NC score	0.068363 (rank : 428)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	206	Target Neighborhood Hits	1005	Shared Neighborhood Hits	41
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.068159 (rank : 429)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	206	Target Neighborhood Hits	1008	Shared Neighborhood Hits	41
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

ACV1C_MOUSE
NC score	0.068100 (rank : 430)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

DOCK1_HUMAN
NC score	0.067919 (rank : 431)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	206	Target Neighborhood Hits	191	Shared Neighborhood Hits	81
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ACV1C_HUMAN
NC score	0.067778 (rank : 432)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	206	Target Neighborhood Hits	709	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

SH22A_MOUSE
NC score	0.067438 (rank : 433)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	206	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

TGFR1_HUMAN
NC score	0.067031 (rank : 434)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	206	Target Neighborhood Hits	755	Shared Neighborhood Hits	40
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.066945 (rank : 435)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	206	Target Neighborhood Hits	753	Shared Neighborhood Hits	40
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TESK2_HUMAN
NC score	0.066877 (rank : 436)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ACV1B_MOUSE
NC score	0.066844 (rank : 437)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	206	Target Neighborhood Hits	753	Shared Neighborhood Hits	40
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.066828 (rank : 438)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	206	Target Neighborhood Hits	753	Shared Neighborhood Hits	40
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

PTN6_MOUSE
NC score	0.066309 (rank : 439)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

TESK2_MOUSE
NC score	0.066285 (rank : 440)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ANKK1_HUMAN
NC score	0.065887 (rank : 441)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	206	Target Neighborhood Hits	1075	Shared Neighborhood Hits	52
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

PTN6_HUMAN
NC score	0.065500 (rank : 442)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	206	Target Neighborhood Hits	234	Shared Neighborhood Hits	52
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

ANKK1_MOUSE
NC score	0.065440 (rank : 443)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	206	Target Neighborhood Hits	1072	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

TESK1_HUMAN
NC score	0.065311 (rank : 444)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	206	Target Neighborhood Hits	864	Shared Neighborhood Hits	43
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
NC score	0.065265 (rank : 445)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	206	Target Neighborhood Hits	862	Shared Neighborhood Hits	42
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

LIMK2_MOUSE
NC score	0.064984 (rank : 446)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	206	Target Neighborhood Hits	998	Shared Neighborhood Hits	41
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

STS2_HUMAN
NC score	0.064961 (rank : 447)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	206	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

RIPK5_HUMAN
NC score	0.064954 (rank : 448)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	206	Target Neighborhood Hits	864	Shared Neighborhood Hits	41
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

LIMK2_HUMAN
NC score	0.064880 (rank : 449)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	206	Target Neighborhood Hits	986	Shared Neighborhood Hits	41
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RIPK5_MOUSE
NC score	0.064746 (rank : 450)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

SH2D3_HUMAN
NC score	0.064602 (rank : 451)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	206	Target Neighborhood Hits	188	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

ACVR1_MOUSE
NC score	0.064518 (rank : 452)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	206	Target Neighborhood Hits	768	Shared Neighborhood Hits	39
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AMHR2_HUMAN
NC score	0.064476 (rank : 453)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	206	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

RIPK4_HUMAN
NC score	0.064475 (rank : 454)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	206	Target Neighborhood Hits	1094	Shared Neighborhood Hits	52
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

NGEF_MOUSE
NC score	0.064425 (rank : 455)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

APS_MOUSE
NC score	0.064261 (rank : 456)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	206	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ACVR1_HUMAN
NC score	0.064170 (rank : 457)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	206	Target Neighborhood Hits	760	Shared Neighborhood Hits	39
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

NGEF_HUMAN
NC score	0.063367 (rank : 458)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	206	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

TCGAP_MOUSE
NC score	0.062650 (rank : 459)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	78
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MCF2L_MOUSE
NC score	0.061894 (rank : 460)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	206	Target Neighborhood Hits	255	Shared Neighborhood Hits	34
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

LRRK1_MOUSE
NC score	0.060914 (rank : 461)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	206	Target Neighborhood Hits	1267	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

HSH2D_MOUSE
NC score	0.060795 (rank : 462)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	206	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

LRRK1_HUMAN
NC score	0.060100 (rank : 463)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	206	Target Neighborhood Hits	1237	Shared Neighborhood Hits	43
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
NC score	0.059911 (rank : 464)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	206	Target Neighborhood Hits	1382	Shared Neighborhood Hits	40
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

TTBK1_HUMAN
NC score	0.059620 (rank : 465)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	47
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

LRRK2_MOUSE
NC score	0.059405 (rank : 466)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	206	Target Neighborhood Hits	1359	Shared Neighborhood Hits	40
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

CI096_HUMAN
NC score	0.058952 (rank : 467)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	206	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

STS1_MOUSE
NC score	0.058912 (rank : 468)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	206	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_HUMAN
NC score	0.058515 (rank : 469)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	206	Target Neighborhood Hits	106	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BLNK_MOUSE
NC score	0.058512 (rank : 470)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	206	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

TENS4_MOUSE
NC score	0.057814 (rank : 471)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

BLNK_HUMAN
NC score	0.057775 (rank : 472)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

NEK11_HUMAN
NC score	0.057741 (rank : 473)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	206	Target Neighborhood Hits	1043	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
NC score	0.057697 (rank : 474)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	206	Target Neighborhood Hits	875	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

AMPH_MOUSE
NC score	0.056909 (rank : 475)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ARHGG_MOUSE
NC score	0.056759 (rank : 476)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	206	Target Neighborhood Hits	152	Shared Neighborhood Hits	36
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG3_HUMAN
NC score	0.056384 (rank : 477)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	206	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.056169 (rank : 478)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

TTBK2_MOUSE
NC score	0.055723 (rank : 479)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	206	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

OXSR1_MOUSE
NC score	0.055668 (rank : 480)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	206	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK39_HUMAN
NC score	0.055554 (rank : 481)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	206	Target Neighborhood Hits	882	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

GAK2_HUMAN
NC score	0.055475 (rank : 482)	θ value	0.0736092 (rank : 70)
Query Neighborhood Hits	206	Target Neighborhood Hits	406	Shared Neighborhood Hits	22
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

STK39_MOUSE
NC score	0.055465 (rank : 483)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	206	Target Neighborhood Hits	915	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

GAK1_HUMAN
NC score	0.055321 (rank : 484)	θ value	0.0961366 (rank : 74)
Query Neighborhood Hits	206	Target Neighborhood Hits	268	Shared Neighborhood Hits	16
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

SH22A_HUMAN
NC score	0.055241 (rank : 485)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	206	Target Neighborhood Hits	144	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

OXSR1_HUMAN
NC score	0.055237 (rank : 486)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	206	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

TTBK2_HUMAN
NC score	0.054750 (rank : 487)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	206	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

WNK2_HUMAN
NC score	0.054612 (rank : 488)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	206	Target Neighborhood Hits	1407	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

AVR2B_MOUSE
NC score	0.054482 (rank : 489)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	206	Target Neighborhood Hits	749	Shared Neighborhood Hits	40
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.054324 (rank : 490)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

GAK6_HUMAN
NC score	0.054162 (rank : 491)	θ value	0.21417 (rank : 91)
Query Neighborhood Hits	206	Target Neighborhood Hits	392	Shared Neighborhood Hits	23
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
NC score	0.054116 (rank : 492)	θ value	0.21417 (rank : 90)
Query Neighborhood Hits	206	Target Neighborhood Hits	415	Shared Neighborhood Hits	22
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.054076 (rank : 493)	θ value	0.21417 (rank : 89)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	22
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

TCGAP_HUMAN
NC score	0.053963 (rank : 494)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	206	Target Neighborhood Hits	872	Shared Neighborhood Hits	90
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STK24_MOUSE
NC score	0.053853 (rank : 495)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	206	Target Neighborhood Hits	856	Shared Neighborhood Hits	41
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

RUSC2_MOUSE
NC score	0.053741 (rank : 496)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	57
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

WNK1_MOUSE
NC score	0.053736 (rank : 497)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	206	Target Neighborhood Hits	1179	Shared Neighborhood Hits	54
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

TAOK2_MOUSE
NC score	0.053687 (rank : 498)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	206	Target Neighborhood Hits	1373	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

MST4_HUMAN
NC score	0.053652 (rank : 499)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	206	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
NC score	0.053575 (rank : 500)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	206	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

BMPR2_HUMAN
NC score	0.053558 (rank : 501)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	206	Target Neighborhood Hits	736	Shared Neighborhood Hits	39
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

STK24_HUMAN
NC score	0.053410 (rank : 502)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	206	Target Neighborhood Hits	853	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

WNK3_HUMAN
NC score	0.053360 (rank : 503)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	206	Target Neighborhood Hits	948	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK1_HUMAN
NC score	0.053149 (rank : 504)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	206	Target Neighborhood Hits	1158	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

MYLK2_HUMAN
NC score	0.053053 (rank : 505)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	206	Target Neighborhood Hits	920	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

BMPR2_MOUSE
NC score	0.053022 (rank : 506)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	206	Target Neighborhood Hits	738	Shared Neighborhood Hits	39
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

ARHG8_MOUSE
NC score	0.052916 (rank : 507)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	206	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

TAOK2_HUMAN
NC score	0.052824 (rank : 508)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	206	Target Neighborhood Hits	1172	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

STK25_MOUSE
NC score	0.052793 (rank : 509)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

NEK7_HUMAN
NC score	0.052678 (rank : 510)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	206	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
NC score	0.052648 (rank : 511)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	206	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

STK25_HUMAN
NC score	0.052646 (rank : 512)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	206	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

YSK4_HUMAN
NC score	0.052539 (rank : 513)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	206	Target Neighborhood Hits	921	Shared Neighborhood Hits	40
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

AVR2A_MOUSE
NC score	0.052523 (rank : 514)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	206	Target Neighborhood Hits	767	Shared Neighborhood Hits	40
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.052521 (rank : 515)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	206	Target Neighborhood Hits	767	Shared Neighborhood Hits	40
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

STK16_MOUSE
NC score	0.052235 (rank : 516)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	206	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

TFCP2_MOUSE
NC score	0.052176 (rank : 517)	θ value	0.365318 (rank : 105)
Query Neighborhood Hits	206	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERA0, Q3UGJ4, Q8VC13	Gene names	Tcfcp2
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2.

M4K4_MOUSE
NC score	0.052158 (rank : 518)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	206	Target Neighborhood Hits	1560	Shared Neighborhood Hits	53
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TFCP2_HUMAN
NC score	0.052146 (rank : 519)	θ value	0.365318 (rank : 104)
Query Neighborhood Hits	206	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q12800, Q12801, Q9UD77	Gene names	TFCP2, LSF, SEF
Domain Architecture	No domain graphic available
Description	Alpha-globin transcription factor CP2 (Transcription factor LSF) (SAA3 enhancer factor).

NEK6_MOUSE
NC score	0.052043 (rank : 520)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	206	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

GAK12_HUMAN
NC score	0.051924 (rank : 521)	θ value	1.38821 (rank : 134)
Query Neighborhood Hits	206	Target Neighborhood Hits	374	Shared Neighborhood Hits	22
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

NEK6_HUMAN
NC score	0.051894 (rank : 522)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	206	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

E2AK2_MOUSE
NC score	0.051711 (rank : 523)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	206	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

ARHG8_HUMAN
NC score	0.051433 (rank : 524)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

PKHG1_HUMAN
NC score	0.050993 (rank : 525)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	206	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

AL2S2_MOUSE
NC score	0.050909 (rank : 526)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	206	Target Neighborhood Hits	709	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
NC score	0.050896 (rank : 527)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	206	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

NEK4_MOUSE
NC score	0.050699 (rank : 528)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	206	Target Neighborhood Hits	899	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

STK16_HUMAN
NC score	0.050692 (rank : 529)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	206	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

MP2K5_MOUSE
NC score	0.050667 (rank : 530)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	206	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

TGFR2_MOUSE
NC score	0.050501 (rank : 531)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_HUMAN
NC score	0.050458 (rank : 532)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

MP2K7_HUMAN
NC score	0.050313 (rank : 533)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

SBK1_MOUSE
NC score	0.050307 (rank : 534)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	206	Target Neighborhood Hits	824	Shared Neighborhood Hits	41
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TIAM1_MOUSE
NC score	0.050306 (rank : 535)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	206	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

MAK_MOUSE
NC score	0.050286 (rank : 536)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	206	Target Neighborhood Hits	873	Shared Neighborhood Hits	41
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MP2K2_MOUSE
NC score	0.050266 (rank : 537)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	206	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

SN1L2_HUMAN
NC score	0.050256 (rank : 538)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	206	Target Neighborhood Hits	964	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MP2K2_HUMAN
NC score	0.050228 (rank : 539)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	206	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

E2AK1_HUMAN
NC score	0.050203 (rank : 540)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	206	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CD2L7_HUMAN
NC score	0.050176 (rank : 541)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	206	Target Neighborhood Hits	1275	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

PRP4B_HUMAN
NC score	0.050173 (rank : 542)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	206	Target Neighborhood Hits	1030	Shared Neighborhood Hits	45
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

NEK3_HUMAN
NC score	0.050076 (rank : 543)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	206	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

ICK_HUMAN
NC score	0.050045 (rank : 544)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	206	Target Neighborhood Hits	867	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

SN1L2_MOUSE
NC score	0.050022 (rank : 545)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	206	Target Neighborhood Hits	944	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

GAK3_HUMAN
NC score	0.049834 (rank : 546)	θ value	4.03905 (rank : 173)
Query Neighborhood Hits	206	Target Neighborhood Hits	182	Shared Neighborhood Hits	12
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PASK_HUMAN
NC score	0.041273 (rank : 547)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	206	Target Neighborhood Hits	857	Shared Neighborhood Hits	43
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

CC036_HUMAN
NC score	0.036860 (rank : 548)	θ value	2.36792 (rank : 148)
Query Neighborhood Hits	206	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q3SXR2, Q3SXR3, Q9H6K8	Gene names	C3orf36
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf36.

SPTA3_MOUSE
NC score	0.034682 (rank : 549)	θ value	1.81305 (rank : 145)
Query Neighborhood Hits	206	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

GTSE1_MOUSE
NC score	0.029144 (rank : 550)	θ value	1.81305 (rank : 141)
Query Neighborhood Hits	206	Target Neighborhood Hits	245	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

MAST1_HUMAN
NC score	0.029019 (rank : 551)	θ value	6.88961 (rank : 194)
Query Neighborhood Hits	206	Target Neighborhood Hits	1146	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
NC score	0.028987 (rank : 552)	θ value	3.0926 (rank : 163)
Query Neighborhood Hits	206	Target Neighborhood Hits	1123	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SFPQ_MOUSE
NC score	0.026147 (rank : 553)	θ value	1.06291 (rank : 130)
Query Neighborhood Hits	206	Target Neighborhood Hits	958	Shared Neighborhood Hits	30
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

PCQAP_HUMAN
NC score	0.024182 (rank : 554)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	206	Target Neighborhood Hits	549	Shared Neighborhood Hits	23
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

UBP2L_MOUSE
NC score	0.023641 (rank : 555)	θ value	5.27518 (rank : 185)
Query Neighborhood Hits	206	Target Neighborhood Hits	173	Shared Neighborhood Hits	12
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

UBP2L_HUMAN
NC score	0.023360 (rank : 556)	θ value	5.27518 (rank : 184)
Query Neighborhood Hits	206	Target Neighborhood Hits	170	Shared Neighborhood Hits	10
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

BAG3_MOUSE
NC score	0.022499 (rank : 557)	θ value	3.0926 (rank : 158)
Query Neighborhood Hits	206	Target Neighborhood Hits	513	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

MINT_MOUSE
NC score	0.022417 (rank : 558)	θ value	1.06291 (rank : 129)
Query Neighborhood Hits	206	Target Neighborhood Hits	1514	Shared Neighborhood Hits	35
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CN105_MOUSE
NC score	0.021426 (rank : 559)	θ value	3.0926 (rank : 160)
Query Neighborhood Hits	206	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CPZ1, Q8R0Q0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf105 homolog.

MAML3_HUMAN
NC score	0.021299 (rank : 560)	θ value	1.38821 (rank : 137)
Query Neighborhood Hits	206	Target Neighborhood Hits	323	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

XBP1_HUMAN
NC score	0.020454 (rank : 561)	θ value	2.36792 (rank : 156)
Query Neighborhood Hits	206	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P17861, Q8WYK6, Q969P1, Q96BD7	Gene names	XBP1, TREB5, XBP2
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5).

MILK1_MOUSE
NC score	0.019926 (rank : 562)	θ value	0.365318 (rank : 101)
Query Neighborhood Hits	206	Target Neighborhood Hits	788	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SFPQ_HUMAN
NC score	0.019434 (rank : 563)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	206	Target Neighborhood Hits	986	Shared Neighborhood Hits	32
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

CKAP2_HUMAN
NC score	0.018792 (rank : 564)	θ value	3.0926 (rank : 159)
Query Neighborhood Hits	206	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWK9, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4	Gene names	CKAP2, LB1, TMAP
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2 (Tumor-associated microtubule- associated protein) (CTCL tumor antigen se20-10).

K0141_HUMAN
NC score	0.018509 (rank : 565)	θ value	3.0926 (rank : 161)
Query Neighborhood Hits	206	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q14154, Q969R4, Q96EU9	Gene names	KIAA0141
Domain Architecture
Description	Protein KIAA0141.

MEF2D_MOUSE
NC score	0.018368 (rank : 566)	θ value	0.813845 (rank : 126)
Query Neighborhood Hits	206	Target Neighborhood Hits	146	Shared Neighborhood Hits	9
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

CECR2_HUMAN
NC score	0.018334 (rank : 567)	θ value	1.06291 (rank : 128)
Query Neighborhood Hits	206	Target Neighborhood Hits	543	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

ARI1A_HUMAN
NC score	0.018238 (rank : 568)	θ value	6.88961 (rank : 188)
Query Neighborhood Hits	206	Target Neighborhood Hits	787	Shared Neighborhood Hits	32
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

UBP36_HUMAN
NC score	0.018034 (rank : 569)	θ value	0.21417 (rank : 95)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

ANR47_HUMAN
NC score	0.017331 (rank : 570)	θ value	0.47712 (rank : 106)
Query Neighborhood Hits	206	Target Neighborhood Hits	369	Shared Neighborhood Hits	12
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

AMELY_HUMAN
NC score	0.016279 (rank : 571)	θ value	5.27518 (rank : 178)
Query Neighborhood Hits	206	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q99218, Q6RWT1	Gene names	AMELY, AMGL, AMGY
Domain Architecture
Description	Amelogenin, Y isoform precursor.

GA2L2_MOUSE
NC score	0.016013 (rank : 572)	θ value	4.03905 (rank : 172)
Query Neighborhood Hits	206	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

MYO15_MOUSE
NC score	0.015430 (rank : 573)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	206	Target Neighborhood Hits	467	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ZAR1_MOUSE
NC score	0.015173 (rank : 574)	θ value	5.27518 (rank : 187)
Query Neighborhood Hits	206	Target Neighborhood Hits	254	Shared Neighborhood Hits	10
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

WASF2_MOUSE
NC score	0.014809 (rank : 575)	θ value	5.27518 (rank : 186)
Query Neighborhood Hits	206	Target Neighborhood Hits	315	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

RERE_MOUSE
NC score	0.014580 (rank : 576)	θ value	5.27518 (rank : 182)
Query Neighborhood Hits	206	Target Neighborhood Hits	785	Shared Neighborhood Hits	28
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TP53B_MOUSE
NC score	0.014266 (rank : 577)	θ value	5.27518 (rank : 183)
Query Neighborhood Hits	206	Target Neighborhood Hits	644	Shared Neighborhood Hits	20
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

GA2L1_MOUSE
NC score	0.013770 (rank : 578)	θ value	6.88961 (rank : 191)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

CARD6_HUMAN
NC score	0.013382 (rank : 579)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	206	Target Neighborhood Hits	145	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

RCOR2_MOUSE
NC score	0.013268 (rank : 580)	θ value	2.36792 (rank : 151)
Query Neighborhood Hits	206	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C796, Q9JMK4	Gene names	Rcor2
Domain Architecture	No domain graphic available
Description	REST corepressor 2 (M-CoREST).

MMP24_HUMAN
NC score	0.012767 (rank : 581)	θ value	4.03905 (rank : 176)
Query Neighborhood Hits	206	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

CT2NL_HUMAN
NC score	0.012699 (rank : 582)	θ value	2.36792 (rank : 149)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

MMP24_MOUSE
NC score	0.012117 (rank : 583)	θ value	5.27518 (rank : 181)
Query Neighborhood Hits	206	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

MRC2_MOUSE
NC score	0.011993 (rank : 584)	θ value	0.47712 (rank : 109)
Query Neighborhood Hits	206	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	Q64449, Q6ZQ64, Q8C6P0	Gene names	Mrc2, Kiaa0709
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Lectin lambda) (CD280 antigen).

MKL1_HUMAN
NC score	0.011812 (rank : 585)	θ value	4.03905 (rank : 175)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

MA1B1_HUMAN
NC score	0.011604 (rank : 586)	θ value	4.03905 (rank : 174)
Query Neighborhood Hits	206	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

XRCC4_HUMAN
NC score	0.010739 (rank : 587)	θ value	6.88961 (rank : 197)
Query Neighborhood Hits	206	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q13426, Q9BS72, Q9UP94	Gene names	XRCC4
Domain Architecture
Description	DNA-repair protein XRCC4 (X-ray repair cross-complementing protein 4).

TRI66_MOUSE
NC score	0.010625 (rank : 588)	θ value	6.88961 (rank : 196)
Query Neighborhood Hits	206	Target Neighborhood Hits	491	Shared Neighborhood Hits	21
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

CCNB3_HUMAN
NC score	0.009903 (rank : 589)	θ value	4.03905 (rank : 171)
Query Neighborhood Hits	206	Target Neighborhood Hits	368	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

ARTN_HUMAN
NC score	0.009728 (rank : 590)	θ value	8.99809 (rank : 199)
Query Neighborhood Hits	206	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T4W7, O95441, O96030, Q6P6A3	Gene names	ARTN, EVN
Domain Architecture	No domain graphic available
Description	Artemin precursor (Enovin) (Neublastin).

RHG05_HUMAN
NC score	0.008897 (rank : 591)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	206	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

TRPV4_HUMAN
NC score	0.008854 (rank : 592)	θ value	2.36792 (rank : 154)
Query Neighborhood Hits	206	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

SEPT4_HUMAN
NC score	0.008080 (rank : 593)	θ value	1.81305 (rank : 142)
Query Neighborhood Hits	206	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O43236, Q9UM58	Gene names	SEPT4, PNUTL2
Domain Architecture
Description	Septin-4 (Peanut-like protein 2) (Brain protein H5) (Cell division control-related protein 2) (hCDCREL-2) (Bradeion beta) (CE5B3 beta) (Cerebral protein 7).

LMAN1_MOUSE
NC score	0.007639 (rank : 594)	θ value	6.88961 (rank : 193)
Query Neighborhood Hits	206	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D0F3	Gene names	Lman1, Ergic53
Domain Architecture
Description	ERGIC-53 protein precursor (ER-Golgi intermediate compartment 53 kDa protein) (Lectin, mannose-binding 1) (p58).

NKX31_MOUSE
NC score	0.007456 (rank : 595)	θ value	0.47712 (rank : 110)
Query Neighborhood Hits	206	Target Neighborhood Hits	379	Shared Neighborhood Hits	7
SwissProt Accessions	P97436, O09087	Gene names	Nkx3-1, Nkx-3.1, Nkx3a
Domain Architecture
Description	Homeobox protein Nkx-3.1.

LAEVR_HUMAN
NC score	0.006737 (rank : 596)	θ value	6.88961 (rank : 192)
Query Neighborhood Hits	206	Target Neighborhood Hits	73	Shared Neighborhood Hits	7
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

PER1_HUMAN
NC score	0.006379 (rank : 597)	θ value	6.88961 (rank : 195)
Query Neighborhood Hits	206	Target Neighborhood Hits	215	Shared Neighborhood Hits	8
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

DCX_MOUSE
NC score	0.006263 (rank : 598)	θ value	6.88961 (rank : 190)
Query Neighborhood Hits	206	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

LTBP2_HUMAN
NC score	0.005378 (rank : 599)	θ value	0.47712 (rank : 108)
Query Neighborhood Hits	206	Target Neighborhood Hits	552	Shared Neighborhood Hits	7
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

TRI47_MOUSE
NC score	0.005234 (rank : 600)	θ value	4.03905 (rank : 177)
Query Neighborhood Hits	206	Target Neighborhood Hits	295	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

INHBA_HUMAN
NC score	0.004355 (rank : 601)	θ value	5.27518 (rank : 180)
Query Neighborhood Hits	206	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P08476, Q14599	Gene names	INHBA
Domain Architecture
Description	Inhibin beta A chain precursor (Activin beta-A chain) (Erythroid differentiation protein) (EDF).

KIF1C_HUMAN
NC score	0.003524 (rank : 602)	θ value	3.0926 (rank : 162)
Query Neighborhood Hits	206	Target Neighborhood Hits	128	Shared Neighborhood Hits	4
SwissProt Accessions	O43896, O75186	Gene names	KIF1C, KIAA0706
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF1C.

KCNQ3_HUMAN
NC score	0.002742 (rank : 603)	θ value	8.99809 (rank : 202)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

FOXC2_HUMAN
NC score	0.002721 (rank : 604)	θ value	8.99809 (rank : 201)
Query Neighborhood Hits	206	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q99958	Gene names	FOXC2, FKHL14, MFH1
Domain Architecture
Description	Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14).

CAC1C_HUMAN
NC score	0.001893 (rank : 605)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	206	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PO2F2_MOUSE
NC score	0.000599 (rank : 606)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	206	Target Neighborhood Hits	353	Shared Neighborhood Hits	3
SwissProt Accessions	Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q61995, Q61996, Q64245	Gene names	Pou2f2, Oct2, Otf2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).