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Network neighborhood for query Sequence : DCX_MOUSE

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DCX_MOUSE
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DCX_HUMAN
θ value	0 (rank : 1)	NC score	0.987987 (rank : 2)
Query Neighborhood Hits	124	Target Neighborhood Hits	141	Shared Neighborhood Hits	79
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	124
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCAK1_HUMAN
θ value	9.54178e-143 (rank : 3)	NC score	0.242290 (rank : 10)
Query Neighborhood Hits	124	Target Neighborhood Hits	877	Shared Neighborhood Hits	24
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	1.2462e-142 (rank : 4)	NC score	0.242629 (rank : 9)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
θ value	3.4016e-132 (rank : 5)	NC score	0.241611 (rank : 11)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	9.26343e-130 (rank : 6)	NC score	0.240057 (rank : 12)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCDC2_MOUSE
θ value	3.51386e-20 (rank : 7)	NC score	0.670711 (rank : 4)
Query Neighborhood Hits	124	Target Neighborhood Hits	247	Shared Neighborhood Hits	19
SwissProt Accessions	Q5DU00, Q5SZU0, Q80Y99	Gene names	Dcdc2, Kiaa1154
Domain Architecture	No domain graphic available
Description	Doublecortin domain-containing protein 2.

RP1_HUMAN
θ value	1.02238e-19 (rank : 8)	NC score	0.619402 (rank : 5)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	P56715	Gene names	RP1, ORP1
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein) (Retinitis pigmentosa 1 protein).

DCDC2_HUMAN
θ value	2.97466e-19 (rank : 9)	NC score	0.706229 (rank : 3)
Query Neighborhood Hits	124	Target Neighborhood Hits	127	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UHG0, Q5VTR8, Q5VTR9, Q86W35, Q9UFD1, Q9ULR6	Gene names	DCDC2, KIAA1154
Domain Architecture
Description	Doublecortin domain-containing protein 2 (RU2S protein).

RP1_MOUSE
θ value	3.28887e-18 (rank : 10)	NC score	0.613737 (rank : 6)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	P56716	Gene names	Rp1, Orp1, Rp1h
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog).

RP1L1_MOUSE
θ value	8.10077e-17 (rank : 11)	NC score	0.595913 (rank : 7)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

RP1L1_HUMAN
θ value	4.44505e-15 (rank : 12)	NC score	0.395799 (rank : 8)
Query Neighborhood Hits	124	Target Neighborhood Hits	1072	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

MYCB2_MOUSE
θ value	0.00390308 (rank : 13)	NC score	0.073354 (rank : 77)
Query Neighborhood Hits	124	Target Neighborhood Hits	307	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

NOLC1_HUMAN
θ value	0.00665767 (rank : 14)	NC score	0.063456 (rank : 189)
Query Neighborhood Hits	124	Target Neighborhood Hits	452	Shared Neighborhood Hits	22
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

TMM24_MOUSE
θ value	0.00665767 (rank : 15)	NC score	0.074776 (rank : 71)
Query Neighborhood Hits	124	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q80X80	Gene names	Tmem24
Domain Architecture	No domain graphic available
Description	Transmembrane protein 24.

MKL2_HUMAN
θ value	0.0431538 (rank : 16)	NC score	0.051059 (rank : 436)
Query Neighborhood Hits	124	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

HRX_HUMAN
θ value	0.0736092 (rank : 17)	NC score	0.042730 (rank : 468)
Query Neighborhood Hits	124	Target Neighborhood Hits	825	Shared Neighborhood Hits	32
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MARCS_HUMAN
θ value	0.0736092 (rank : 18)	NC score	0.089047 (rank : 20)
Query Neighborhood Hits	124	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

CABP4_MOUSE
θ value	0.0961366 (rank : 19)	NC score	0.018782 (rank : 515)
Query Neighborhood Hits	124	Target Neighborhood Hits	212	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHC5	Gene names	Cabp4
Domain Architecture	No domain graphic available
Description	Calcium-binding protein 4 (CaBP4).

MYCB2_HUMAN
θ value	0.125558 (rank : 20)	NC score	0.060842 (rank : 225)
Query Neighborhood Hits	124	Target Neighborhood Hits	390	Shared Neighborhood Hits	20
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

IF35_HUMAN
θ value	0.163984 (rank : 21)	NC score	0.047035 (rank : 462)
Query Neighborhood Hits	124	Target Neighborhood Hits	130	Shared Neighborhood Hits	10
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

UBN1_HUMAN
θ value	0.163984 (rank : 22)	NC score	0.070289 (rank : 100)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

CNOT3_MOUSE
θ value	0.21417 (rank : 23)	NC score	0.048145 (rank : 461)
Query Neighborhood Hits	124	Target Neighborhood Hits	504	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

BSN_HUMAN
θ value	0.279714 (rank : 24)	NC score	0.046401 (rank : 464)
Query Neighborhood Hits	124	Target Neighborhood Hits	1537	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

DYNA_HUMAN
θ value	0.365318 (rank : 25)	NC score	0.025966 (rank : 501)
Query Neighborhood Hits	124	Target Neighborhood Hits	1194	Shared Neighborhood Hits	18
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	0.365318 (rank : 26)	NC score	0.026920 (rank : 499)
Query Neighborhood Hits	124	Target Neighborhood Hits	1084	Shared Neighborhood Hits	16
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

NFAC3_HUMAN
θ value	0.365318 (rank : 27)	NC score	0.035300 (rank : 479)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

NFH_HUMAN
θ value	0.365318 (rank : 28)	NC score	0.013306 (rank : 527)
Query Neighborhood Hits	124	Target Neighborhood Hits	1242	Shared Neighborhood Hits	31
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ATRX_MOUSE
θ value	0.47712 (rank : 29)	NC score	0.027034 (rank : 498)
Query Neighborhood Hits	124	Target Neighborhood Hits	682	Shared Neighborhood Hits	25
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

NFAC3_MOUSE
θ value	0.47712 (rank : 30)	NC score	0.036024 (rank : 475)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	P97305, Q60896	Gene names	Nfatc3, Nfat4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

SOX18_HUMAN
θ value	0.47712 (rank : 31)	NC score	0.016108 (rank : 518)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	P35713, Q9NPH8	Gene names	SOX18
Domain Architecture
Description	Transcription factor SOX-18.

K1802_HUMAN
θ value	0.62314 (rank : 32)	NC score	0.027675 (rank : 495)
Query Neighborhood Hits	124	Target Neighborhood Hits	1378	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

PCDGG_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.013377 (rank : 525)
Query Neighborhood Hits	124	Target Neighborhood Hits	163	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN71, O15099, Q9UN64	Gene names	PCDHGB4, CDH20, FIB2
Domain Architecture
Description	Protocadherin gamma B4 precursor (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin 2).

RFA1_MOUSE
θ value	0.62314 (rank : 34)	NC score	0.030014 (rank : 490)
Query Neighborhood Hits	124	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VEE4, Q3TEJ8	Gene names	Rpa1
Domain Architecture	No domain graphic available
Description	Replication protein A 70 kDa DNA-binding subunit (RP-A) (RF-A) (Replication factor-A protein 1) (p70).

SREC2_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.011279 (rank : 531)
Query Neighborhood Hits	124	Target Neighborhood Hits	645	Shared Neighborhood Hits	17
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

DBP_HUMAN
θ value	0.813845 (rank : 36)	NC score	0.035281 (rank : 480)
Query Neighborhood Hits	124	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	Q10586	Gene names	DBP
Domain Architecture
Description	D site-binding protein (Albumin D box-binding protein) (Albumin D- element-binding protein) (TAXREB302).

MUC7_HUMAN
θ value	0.813845 (rank : 37)	NC score	0.043514 (rank : 466)
Query Neighborhood Hits	124	Target Neighborhood Hits	538	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MARCS_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.056393 (rank : 303)
Query Neighborhood Hits	124	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

SYN3_MOUSE
θ value	1.06291 (rank : 39)	NC score	0.035067 (rank : 481)
Query Neighborhood Hits	124	Target Neighborhood Hits	200	Shared Neighborhood Hits	20
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

TAF6_MOUSE
θ value	1.06291 (rank : 40)	NC score	0.025014 (rank : 503)
Query Neighborhood Hits	124	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

TF3C1_HUMAN
θ value	1.06291 (rank : 41)	NC score	0.022948 (rank : 507)
Query Neighborhood Hits	124	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

XRCC1_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.032917 (rank : 482)
Query Neighborhood Hits	124	Target Neighborhood Hits	242	Shared Neighborhood Hits	11
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

BTBDC_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.030988 (rank : 488)
Query Neighborhood Hits	124	Target Neighborhood Hits	248	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

HXB5_HUMAN
θ value	1.38821 (rank : 44)	NC score	0.006200 (rank : 549)
Query Neighborhood Hits	124	Target Neighborhood Hits	332	Shared Neighborhood Hits	6
SwissProt Accessions	P09067, P09069	Gene names	HOXB5, HOX2A
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2A) (HHO.C10) (HU-1).

MRCKA_HUMAN
θ value	1.38821 (rank : 45)	NC score	0.051940 (rank : 411)
Query Neighborhood Hits	124	Target Neighborhood Hits	1999	Shared Neighborhood Hits	29
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

SRRM1_HUMAN
θ value	1.38821 (rank : 46)	NC score	0.044944 (rank : 465)
Query Neighborhood Hits	124	Target Neighborhood Hits	690	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM2_HUMAN
θ value	1.38821 (rank : 47)	NC score	0.043022 (rank : 467)
Query Neighborhood Hits	124	Target Neighborhood Hits	1296	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ZBTB4_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.007179 (rank : 543)
Query Neighborhood Hits	124	Target Neighborhood Hits	926	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

DCDC1_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.068962 (rank : 119)
Query Neighborhood Hits	124	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P59894	Gene names	DCDC1
Domain Architecture	No domain graphic available
Description	Doublecortin domain-containing protein 1.

MUC1_HUMAN
θ value	1.81305 (rank : 50)	NC score	0.035746 (rank : 476)
Query Neighborhood Hits	124	Target Neighborhood Hits	975	Shared Neighborhood Hits	58
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MUC2_HUMAN
θ value	1.81305 (rank : 51)	NC score	0.019312 (rank : 513)
Query Neighborhood Hits	124	Target Neighborhood Hits	906	Shared Neighborhood Hits	26
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NU214_HUMAN
θ value	1.81305 (rank : 52)	NC score	0.046873 (rank : 463)
Query Neighborhood Hits	124	Target Neighborhood Hits	657	Shared Neighborhood Hits	33
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PCDGH_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.010795 (rank : 533)
Query Neighborhood Hits	124	Target Neighborhood Hits	164	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y5G0, Q9Y5C6	Gene names	PCDHGB5
Domain Architecture
Description	Protocadherin gamma B5 precursor (PCDH-gamma-B5).

PHLB1_HUMAN
θ value	1.81305 (rank : 54)	NC score	0.025295 (rank : 502)
Query Neighborhood Hits	124	Target Neighborhood Hits	1038	Shared Neighborhood Hits	38
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RBM5_HUMAN
θ value	1.81305 (rank : 55)	NC score	0.031100 (rank : 487)
Query Neighborhood Hits	124	Target Neighborhood Hits	216	Shared Neighborhood Hits	6
SwissProt Accessions	P52756, Q93021, Q9BU14, Q9UKY8, Q9UL24	Gene names	RBM5
Domain Architecture
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15) (Protein G15) (NY-REN-9 antigen).

RD23A_HUMAN
θ value	1.81305 (rank : 56)	NC score	0.019070 (rank : 514)
Query Neighborhood Hits	124	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	P54725	Gene names	RAD23A
Domain Architecture
Description	UV excision repair protein RAD23 homolog A (hHR23A).

BSN_MOUSE
θ value	2.36792 (rank : 57)	NC score	0.048359 (rank : 460)
Query Neighborhood Hits	124	Target Neighborhood Hits	2057	Shared Neighborhood Hits	78
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CN004_HUMAN
θ value	2.36792 (rank : 58)	NC score	0.036263 (rank : 473)
Query Neighborhood Hits	124	Target Neighborhood Hits	108	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

CN004_MOUSE
θ value	2.36792 (rank : 59)	NC score	0.037753 (rank : 471)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

MARK2_MOUSE
θ value	2.36792 (rank : 60)	NC score	0.068321 (rank : 131)
Query Neighborhood Hits	124	Target Neighborhood Hits	1018	Shared Neighborhood Hits	30
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MK07_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.058276 (rank : 276)
Query Neighborhood Hits	124	Target Neighborhood Hits	1087	Shared Neighborhood Hits	24
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

RBM5_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.035517 (rank : 478)
Query Neighborhood Hits	124	Target Neighborhood Hits	216	Shared Neighborhood Hits	7
SwissProt Accessions	Q91YE7, Q3UZ19, Q99KV9	Gene names	Rbm5, Luca15
Domain Architecture	No domain graphic available
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15).

SET1A_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.036121 (rank : 474)
Query Neighborhood Hits	124	Target Neighborhood Hits	690	Shared Neighborhood Hits	33
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SRRM2_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.053410 (rank : 373)
Query Neighborhood Hits	124	Target Neighborhood Hits	1470	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SYTL2_MOUSE
θ value	2.36792 (rank : 65)	NC score	0.012752 (rank : 528)
Query Neighborhood Hits	124	Target Neighborhood Hits	253	Shared Neighborhood Hits	14
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

UBQL2_HUMAN
θ value	2.36792 (rank : 66)	NC score	0.020149 (rank : 511)
Query Neighborhood Hits	124	Target Neighborhood Hits	103	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD9, O94798, Q9H3W6, Q9HAZ4	Gene names	UBQLN2, PLIC2
Domain Architecture
Description	Ubiquilin-2 (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC- 2) (Ubiquitin-like product Chap1/Dsk2) (DSK2 homolog) (Chap1).

3BP1_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.023560 (rank : 505)
Query Neighborhood Hits	124	Target Neighborhood Hits	376	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

BAG3_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.022994 (rank : 506)
Query Neighborhood Hits	124	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

HDAC2_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.008419 (rank : 537)
Query Neighborhood Hits	124	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q92769, Q5SRI8, Q5SZ86, Q8NEH4	Gene names	HDAC2
Domain Architecture
Description	Histone deacetylase 2 (HD2).

LMX1A_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.006954 (rank : 545)
Query Neighborhood Hits	124	Target Neighborhood Hits	406	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE12, Q8TE11	Gene names	LMX1A
Domain Architecture
Description	LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM-homeobox protein 1.1) (LMX-1.1).

MAST4_HUMAN
θ value	3.0926 (rank : 71)	NC score	0.067424 (rank : 141)
Query Neighborhood Hits	124	Target Neighborhood Hits	1804	Shared Neighborhood Hits	64
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SFR16_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.037817 (rank : 470)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

AFF1_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.024573 (rank : 504)
Query Neighborhood Hits	124	Target Neighborhood Hits	506	Shared Neighborhood Hits	29
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

CBX6_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.012004 (rank : 529)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	9
SwissProt Accessions	O95503, Q96EM5	Gene names	CBX6
Domain Architecture
Description	Chromobox protein homolog 6.

CS016_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.031919 (rank : 486)
Query Neighborhood Hits	124	Target Neighborhood Hits	310	Shared Neighborhood Hits	19
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DOC2B_MOUSE
θ value	4.03905 (rank : 76)	NC score	0.006288 (rank : 547)
Query Neighborhood Hits	124	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

LIPB2_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.008078 (rank : 540)
Query Neighborhood Hits	124	Target Neighborhood Hits	570	Shared Neighborhood Hits	15
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

MDN1_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.029610 (rank : 491)
Query Neighborhood Hits	124	Target Neighborhood Hits	662	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SRRM1_MOUSE
θ value	4.03905 (rank : 79)	NC score	0.050590 (rank : 445)
Query Neighborhood Hits	124	Target Neighborhood Hits	966	Shared Neighborhood Hits	50
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SYN2_MOUSE
θ value	4.03905 (rank : 80)	NC score	0.027449 (rank : 497)
Query Neighborhood Hits	124	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	Q64332, Q6NZR0, Q9QWV7	Gene names	Syn2
Domain Architecture	No domain graphic available
Description	Synapsin-2 (Synapsin II).

BCL3_MOUSE
θ value	5.27518 (rank : 81)	NC score	0.005787 (rank : 550)
Query Neighborhood Hits	124	Target Neighborhood Hits	388	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

CO5A2_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.007439 (rank : 542)
Query Neighborhood Hits	124	Target Neighborhood Hits	760	Shared Neighborhood Hits	19
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

HXB5_MOUSE
θ value	5.27518 (rank : 83)	NC score	0.004793 (rank : 552)
Query Neighborhood Hits	124	Target Neighborhood Hits	337	Shared Neighborhood Hits	7
SwissProt Accessions	P09079, Q3ZAY8	Gene names	Hoxb5, Hox-2.1, Hoxb-5
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2.1) (MU-1) (H24.1).

MINT_MOUSE
θ value	5.27518 (rank : 84)	NC score	0.028432 (rank : 492)
Query Neighborhood Hits	124	Target Neighborhood Hits	1514	Shared Neighborhood Hits	56
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MSH6_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.010211 (rank : 535)
Query Neighborhood Hits	124	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	P52701, O43706, O43917, Q8TCX4, Q9BTB5	Gene names	MSH6, GTBP
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

PAPOA_HUMAN
θ value	5.27518 (rank : 86)	NC score	0.008251 (rank : 539)
Query Neighborhood Hits	124	Target Neighborhood Hits	75	Shared Neighborhood Hits	6
SwissProt Accessions	P51003, Q86SX4, Q86TV0, Q8IYF5, Q9BVU2	Gene names	PAPOLA, PAP
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase alpha (EC 2.7.7.19) (PAP) (Polynucleotide adenylyltransferase alpha).

PCLO_MOUSE
θ value	5.27518 (rank : 87)	NC score	0.032106 (rank : 484)
Query Neighborhood Hits	124	Target Neighborhood Hits	2275	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PRDM2_HUMAN
θ value	5.27518 (rank : 88)	NC score	0.008358 (rank : 538)
Query Neighborhood Hits	124	Target Neighborhood Hits	1135	Shared Neighborhood Hits	26
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

RPB1_HUMAN
θ value	5.27518 (rank : 89)	NC score	0.028305 (rank : 493)
Query Neighborhood Hits	124	Target Neighborhood Hits	362	Shared Neighborhood Hits	17
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.030256 (rank : 489)
Query Neighborhood Hits	124	Target Neighborhood Hits	363	Shared Neighborhood Hits	18
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SFR12_MOUSE
θ value	5.27518 (rank : 91)	NC score	0.010882 (rank : 532)
Query Neighborhood Hits	124	Target Neighborhood Hits	486	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

SYN1_HUMAN
θ value	5.27518 (rank : 92)	NC score	0.027772 (rank : 494)
Query Neighborhood Hits	124	Target Neighborhood Hits	419	Shared Neighborhood Hits	25
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

SYN3_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.027637 (rank : 496)
Query Neighborhood Hits	124	Target Neighborhood Hits	203	Shared Neighborhood Hits	15
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

YTDC1_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.026745 (rank : 500)
Query Neighborhood Hits	124	Target Neighborhood Hits	458	Shared Neighborhood Hits	18
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ZAR1_MOUSE
θ value	5.27518 (rank : 95)	NC score	0.035587 (rank : 477)
Query Neighborhood Hits	124	Target Neighborhood Hits	254	Shared Neighborhood Hits	24
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

AAKG2_MOUSE
θ value	6.88961 (rank : 96)	NC score	0.013982 (rank : 522)
Query Neighborhood Hits	124	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q91WG5, Q6V7V5	Gene names	Prkag2
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma-2 chain) (AMPK gamma2).

ATS4_HUMAN
θ value	6.88961 (rank : 97)	NC score	0.002286 (rank : 554)
Query Neighborhood Hits	124	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

DUS8_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.006965 (rank : 544)
Query Neighborhood Hits	124	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

ES8L3_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.006263 (rank : 548)
Query Neighborhood Hits	124	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PDXL2_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.036900 (rank : 472)
Query Neighborhood Hits	124	Target Neighborhood Hits	213	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

PHLB1_MOUSE
θ value	6.88961 (rank : 101)	NC score	0.021515 (rank : 508)
Query Neighborhood Hits	124	Target Neighborhood Hits	678	Shared Neighborhood Hits	24
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RFIP5_MOUSE
θ value	6.88961 (rank : 102)	NC score	0.019370 (rank : 512)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

RTBDN_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.014733 (rank : 521)
Query Neighborhood Hits	124	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BSG5, Q9BWT5	Gene names	RTBDN
Domain Architecture	No domain graphic available
Description	Retbindin precursor.

SYNJ1_MOUSE
θ value	6.88961 (rank : 104)	NC score	0.016801 (rank : 516)
Query Neighborhood Hits	124	Target Neighborhood Hits	516	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

VEGFB_HUMAN
θ value	6.88961 (rank : 105)	NC score	0.011476 (rank : 530)
Query Neighborhood Hits	124	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	P49765, Q16528	Gene names	VEGFB, VRF
Domain Architecture
Description	Vascular endothelial growth factor B precursor (VEGF-B) (VEGF-related factor) (VRF).

WWP2_HUMAN
θ value	6.88961 (rank : 106)	NC score	0.004954 (rank : 551)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

ZN592_HUMAN
θ value	6.88961 (rank : 107)	NC score	0.001561 (rank : 556)
Query Neighborhood Hits	124	Target Neighborhood Hits	762	Shared Neighborhood Hits	10
SwissProt Accessions	Q92610	Gene names	ZNF592, KIAA0211
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592.

ZN592_MOUSE
θ value	6.88961 (rank : 108)	NC score	0.001705 (rank : 555)
Query Neighborhood Hits	124	Target Neighborhood Hits	768	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BHZ4, Q80XM1	Gene names	Znf592, Kiaa0211, Zfp592
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592 (Zfp-592).

3BP1_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.010404 (rank : 534)
Query Neighborhood Hits	124	Target Neighborhood Hits	238	Shared Neighborhood Hits	13
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

5NT1B_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.015250 (rank : 519)
Query Neighborhood Hits	124	Target Neighborhood Hits	83	Shared Neighborhood Hits	10
SwissProt Accessions	Q96P26, Q8N9W3, Q8NA26, Q96DU5, Q96KE6, Q96M25, Q96SA3	Gene names	NT5C1B, AIRP
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

B3A2_HUMAN
θ value	8.99809 (rank : 111)	NC score	0.003860 (rank : 553)
Query Neighborhood Hits	124	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

BASP_HUMAN
θ value	8.99809 (rank : 112)	NC score	0.039400 (rank : 469)
Query Neighborhood Hits	124	Target Neighborhood Hits	321	Shared Neighborhood Hits	23
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

CAC1G_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.013316 (rank : 526)
Query Neighborhood Hits	124	Target Neighborhood Hits	587	Shared Neighborhood Hits	40
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CUTL1_HUMAN
θ value	8.99809 (rank : 114)	NC score	0.013853 (rank : 524)
Query Neighborhood Hits	124	Target Neighborhood Hits	1574	Shared Neighborhood Hits	35
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

GA2L3_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.015028 (rank : 520)
Query Neighborhood Hits	124	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XJ1	Gene names	GAS2L3
Domain Architecture	No domain graphic available
Description	GAS2-like protein 3 (Growth arrest-specific 2-like 3).

INSRR_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.032504 (rank : 483)
Query Neighborhood Hits	124	Target Neighborhood Hits	950	Shared Neighborhood Hits	13
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

K1802_MOUSE
θ value	8.99809 (rank : 117)	NC score	0.031948 (rank : 485)
Query Neighborhood Hits	124	Target Neighborhood Hits	1596	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MADCA_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.013974 (rank : 523)
Query Neighborhood Hits	124	Target Neighborhood Hits	221	Shared Neighborhood Hits	14
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MMP9_MOUSE
θ value	8.99809 (rank : 119)	NC score	0.009896 (rank : 536)
Query Neighborhood Hits	124	Target Neighborhood Hits	151	Shared Neighborhood Hits	9
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

PCDGJ_HUMAN
θ value	8.99809 (rank : 120)	NC score	0.007442 (rank : 541)
Query Neighborhood Hits	124	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y5F8, Q9UN63	Gene names	PCDHGB7
Domain Architecture
Description	Protocadherin gamma B7 precursor (PCDH-gamma-B7).

PCQAP_HUMAN
θ value	8.99809 (rank : 121)	NC score	0.021129 (rank : 510)
Query Neighborhood Hits	124	Target Neighborhood Hits	549	Shared Neighborhood Hits	23
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PCQAP_MOUSE
θ value	8.99809 (rank : 122)	NC score	0.021445 (rank : 509)
Query Neighborhood Hits	124	Target Neighborhood Hits	506	Shared Neighborhood Hits	18
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

UBP31_HUMAN
θ value	8.99809 (rank : 123)	NC score	0.006883 (rank : 546)
Query Neighborhood Hits	124	Target Neighborhood Hits	293	Shared Neighborhood Hits	17
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

ZC3H3_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.016561 (rank : 517)
Query Neighborhood Hits	124	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

AAPK1_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.066767 (rank : 147)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.066725 (rank : 148)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.067963 (rank : 134)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AKT1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.058541 (rank : 271)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	9
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.058549 (rank : 270)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	9
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT2_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.059166 (rank : 250)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	9
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.058898 (rank : 263)
Query Neighborhood Hits	124	Target Neighborhood Hits	875	Shared Neighborhood Hits	9
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.058053 (rank : 280)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.058050 (rank : 281)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AL2S7_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.053699 (rank : 364)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	9
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ARAF_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.050885 (rank : 437)
Query Neighborhood Hits	124	Target Neighborhood Hits	924	Shared Neighborhood Hits	16
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARBK1_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.053631 (rank : 365)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	9
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.053178 (rank : 380)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.054475 (rank : 345)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

AURKB_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.066079 (rank : 159)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.064416 (rank : 180)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.063268 (rank : 190)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.063090 (rank : 192)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	9
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

BRSK1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.067271 (rank : 142)
Query Neighborhood Hits	124	Target Neighborhood Hits	942	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.064902 (rank : 175)
Query Neighborhood Hits	124	Target Neighborhood Hits	897	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

BUB1B_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.059265 (rank : 248)
Query Neighborhood Hits	124	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.058381 (rank : 272)
Query Neighborhood Hits	124	Target Neighborhood Hits	543	Shared Neighborhood Hits	17
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

BUB1_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.052992 (rank : 388)
Query Neighborhood Hits	124	Target Neighborhood Hits	583	Shared Neighborhood Hits	8
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CAMKV_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.104018 (rank : 13)
Query Neighborhood Hits	124	Target Neighborhood Hits	1084	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.100111 (rank : 14)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	16
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CDC7_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.053112 (rank : 382)
Query Neighborhood Hits	124	Target Neighborhood Hits	641	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CDK3_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.051217 (rank : 430)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK6_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.052739 (rank : 394)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.052244 (rank : 404)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDKL1_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.057101 (rank : 293)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.055520 (rank : 323)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.053238 (rank : 379)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.054054 (rank : 357)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL3_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.054246 (rank : 351)
Query Neighborhood Hits	124	Target Neighborhood Hits	853	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.054777 (rank : 332)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.052256 (rank : 403)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.053976 (rank : 360)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.051305 (rank : 426)
Query Neighborhood Hits	124	Target Neighborhood Hits	967	Shared Neighborhood Hits	22
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CHK1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.065740 (rank : 166)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.065828 (rank : 164)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK2_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.077168 (rank : 58)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	9
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

CHK2_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.076248 (rank : 61)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

CLK1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.060998 (rank : 223)
Query Neighborhood Hits	124	Target Neighborhood Hits	756	Shared Neighborhood Hits	9
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK1_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.062875 (rank : 197)
Query Neighborhood Hits	124	Target Neighborhood Hits	760	Shared Neighborhood Hits	10
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK2_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.072457 (rank : 79)
Query Neighborhood Hits	124	Target Neighborhood Hits	752	Shared Neighborhood Hits	9
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK2_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.071846 (rank : 84)
Query Neighborhood Hits	124	Target Neighborhood Hits	743	Shared Neighborhood Hits	9
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK3_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.075343 (rank : 68)
Query Neighborhood Hits	124	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.075340 (rank : 70)
Query Neighborhood Hits	124	Target Neighborhood Hits	761	Shared Neighborhood Hits	9
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK4_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.063084 (rank : 193)
Query Neighborhood Hits	124	Target Neighborhood Hits	759	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.062732 (rank : 201)
Query Neighborhood Hits	124	Target Neighborhood Hits	759	Shared Neighborhood Hits	9
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CSK21_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.055738 (rank : 320)
Query Neighborhood Hits	124	Target Neighborhood Hits	772	Shared Neighborhood Hits	8
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.054455 (rank : 346)
Query Neighborhood Hits	124	Target Neighborhood Hits	770	Shared Neighborhood Hits	8
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK22_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.054086 (rank : 356)
Query Neighborhood Hits	124	Target Neighborhood Hits	758	Shared Neighborhood Hits	9
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.053938 (rank : 361)
Query Neighborhood Hits	124	Target Neighborhood Hits	758	Shared Neighborhood Hits	9
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSKP_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.074146 (rank : 73)
Query Neighborhood Hits	124	Target Neighborhood Hits	1022	Shared Neighborhood Hits	10
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.074371 (rank : 72)
Query Neighborhood Hits	124	Target Neighborhood Hits	1027	Shared Neighborhood Hits	10
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CTRO_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.051355 (rank : 424)
Query Neighborhood Hits	124	Target Neighborhood Hits	2092	Shared Neighborhood Hits	27
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.051569 (rank : 419)
Query Neighborhood Hits	124	Target Neighborhood Hits	2344	Shared Neighborhood Hits	34
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DAPK1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.069710 (rank : 108)
Query Neighborhood Hits	124	Target Neighborhood Hits	1130	Shared Neighborhood Hits	10
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.068986 (rank : 118)
Query Neighborhood Hits	124	Target Neighborhood Hits	1138	Shared Neighborhood Hits	10
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.077417 (rank : 56)
Query Neighborhood Hits	124	Target Neighborhood Hits	832	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.077343 (rank : 57)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.077156 (rank : 59)
Query Neighborhood Hits	124	Target Neighborhood Hits	945	Shared Neighborhood Hits	9
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.076909 (rank : 60)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK3_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.095042 (rank : 16)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	12
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.093711 (rank : 17)
Query Neighborhood Hits	124	Target Neighborhood Hits	922	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DMPK_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.054845 (rank : 331)
Query Neighborhood Hits	124	Target Neighborhood Hits	944	Shared Neighborhood Hits	10
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.054615 (rank : 339)
Query Neighborhood Hits	124	Target Neighborhood Hits	908	Shared Neighborhood Hits	10
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DUET_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.076192 (rank : 62)
Query Neighborhood Hits	124	Target Neighborhood Hits	1220	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYR1A_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.053041 (rank : 385)
Query Neighborhood Hits	124	Target Neighborhood Hits	764	Shared Neighborhood Hits	8
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.053033 (rank : 386)
Query Neighborhood Hits	124	Target Neighborhood Hits	762	Shared Neighborhood Hits	8
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.055942 (rank : 313)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYR1B_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.056105 (rank : 309)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYRK2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.057051 (rank : 295)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	9
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

DYRK3_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.058351 (rank : 273)
Query Neighborhood Hits	124	Target Neighborhood Hits	798	Shared Neighborhood Hits	9
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

DYRK4_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.061675 (rank : 215)
Query Neighborhood Hits	124	Target Neighborhood Hits	750	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

E2AK1_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.051991 (rank : 410)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.051311 (rank : 425)
Query Neighborhood Hits	124	Target Neighborhood Hits	856	Shared Neighborhood Hits	9
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK3_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.055568 (rank : 321)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.052546 (rank : 397)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

ERN1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.057091 (rank : 294)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN1_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.059408 (rank : 245)
Query Neighborhood Hits	124	Target Neighborhood Hits	823	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.057707 (rank : 284)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	9
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.051468 (rank : 422)
Query Neighborhood Hits	124	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

F5006_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.065874 (rank : 163)
Query Neighborhood Hits	124	Target Neighborhood Hits	794	Shared Neighborhood Hits	9
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.062863 (rank : 198)
Query Neighborhood Hits	124	Target Neighborhood Hits	793	Shared Neighborhood Hits	9
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

GAK_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.067806 (rank : 137)
Query Neighborhood Hits	124	Target Neighborhood Hits	1028	Shared Neighborhood Hits	24
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.066349 (rank : 152)
Query Neighborhood Hits	124	Target Neighborhood Hits	964	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GRK4_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.054569 (rank : 340)
Query Neighborhood Hits	124	Target Neighborhood Hits	822	Shared Neighborhood Hits	9
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.053715 (rank : 363)
Query Neighborhood Hits	124	Target Neighborhood Hits	808	Shared Neighborhood Hits	9
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.057366 (rank : 288)
Query Neighborhood Hits	124	Target Neighborhood Hits	819	Shared Neighborhood Hits	9
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.057580 (rank : 286)
Query Neighborhood Hits	124	Target Neighborhood Hits	823	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.055522 (rank : 322)
Query Neighborhood Hits	124	Target Neighborhood Hits	823	Shared Neighborhood Hits	9
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.055235 (rank : 326)
Query Neighborhood Hits	124	Target Neighborhood Hits	820	Shared Neighborhood Hits	9
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK7_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.063604 (rank : 188)
Query Neighborhood Hits	124	Target Neighborhood Hits	820	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

GSK3A_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.050599 (rank : 444)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	11
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

GSK3B_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.050764 (rank : 442)
Query Neighborhood Hits	124	Target Neighborhood Hits	801	Shared Neighborhood Hits	9
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.050763 (rank : 443)
Query Neighborhood Hits	124	Target Neighborhood Hits	800	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

HIPK1_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.054682 (rank : 334)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	13
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.054511 (rank : 344)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	13
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK2_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.053482 (rank : 370)
Query Neighborhood Hits	124	Target Neighborhood Hits	845	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.053876 (rank : 362)
Query Neighborhood Hits	124	Target Neighborhood Hits	871	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

HIPK3_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.053459 (rank : 372)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.054016 (rank : 358)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK4_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.056140 (rank : 308)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

HUNK_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.066121 (rank : 157)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	10
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.066174 (rank : 156)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

IKKA_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.051482 (rank : 421)
Query Neighborhood Hits	124	Target Neighborhood Hits	863	Shared Neighborhood Hits	9
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.051829 (rank : 414)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	9
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.056693 (rank : 300)
Query Neighborhood Hits	124	Target Neighborhood Hits	980	Shared Neighborhood Hits	11
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.057668 (rank : 285)
Query Neighborhood Hits	124	Target Neighborhood Hits	984	Shared Neighborhood Hits	10
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.056043 (rank : 311)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.059079 (rank : 256)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IRAK2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.056294 (rank : 304)
Query Neighborhood Hits	124	Target Neighborhood Hits	714	Shared Neighborhood Hits	14
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.050780 (rank : 441)
Query Neighborhood Hits	124	Target Neighborhood Hits	644	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

K0999_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.068167 (rank : 132)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.068572 (rank : 126)
Query Neighborhood Hits	124	Target Neighborhood Hits	931	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K2002_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.081312 (rank : 44)
Query Neighborhood Hits	124	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KAPCA_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.066174 (rank : 155)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.066093 (rank : 158)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.066249 (rank : 154)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.066567 (rank : 150)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCG_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.066676 (rank : 149)
Query Neighborhood Hits	124	Target Neighborhood Hits	845	Shared Neighborhood Hits	9
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KC1A_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.051133 (rank : 433)
Query Neighborhood Hits	124	Target Neighborhood Hits	728	Shared Neighborhood Hits	8
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.051133 (rank : 434)
Query Neighborhood Hits	124	Target Neighborhood Hits	728	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KCC1A_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.083816 (rank : 31)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.083998 (rank : 30)
Query Neighborhood Hits	124	Target Neighborhood Hits	845	Shared Neighborhood Hits	9
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.085368 (rank : 21)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.085309 (rank : 22)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.082916 (rank : 35)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.082939 (rank : 34)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.080755 (rank : 49)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	10
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.080925 (rank : 47)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	10
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2A_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.082844 (rank : 36)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.083026 (rank : 33)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.084359 (rank : 27)
Query Neighborhood Hits	124	Target Neighborhood Hits	866	Shared Neighborhood Hits	13
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.084128 (rank : 29)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	11
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2D_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.081395 (rank : 43)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KCC2G_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.082650 (rank : 38)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	9
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.082649 (rank : 39)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC4_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.084823 (rank : 25)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	9
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.084339 (rank : 28)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	9
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KGP1A_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.055876 (rank : 315)
Query Neighborhood Hits	124	Target Neighborhood Hits	901	Shared Neighborhood Hits	9
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.056044 (rank : 310)
Query Neighborhood Hits	124	Target Neighborhood Hits	921	Shared Neighborhood Hits	11
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.056042 (rank : 312)
Query Neighborhood Hits	124	Target Neighborhood Hits	922	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.058800 (rank : 265)
Query Neighborhood Hits	124	Target Neighborhood Hits	1023	Shared Neighborhood Hits	14
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.058760 (rank : 267)
Query Neighborhood Hits	124	Target Neighborhood Hits	1029	Shared Neighborhood Hits	16
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KKCC1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.068338 (rank : 130)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.068881 (rank : 121)
Query Neighborhood Hits	124	Target Neighborhood Hits	866	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.068655 (rank : 125)
Query Neighborhood Hits	124	Target Neighborhood Hits	852	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.068523 (rank : 127)
Query Neighborhood Hits	124	Target Neighborhood Hits	855	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCA_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.052558 (rank : 396)
Query Neighborhood Hits	124	Target Neighborhood Hits	1070	Shared Neighborhood Hits	12
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.051698 (rank : 416)
Query Neighborhood Hits	124	Target Neighborhood Hits	1067	Shared Neighborhood Hits	12
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.051897 (rank : 412)
Query Neighborhood Hits	124	Target Neighborhood Hits	1121	Shared Neighborhood Hits	12
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.052098 (rank : 409)
Query Neighborhood Hits	124	Target Neighborhood Hits	1117	Shared Neighborhood Hits	12
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD1_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.071632 (rank : 88)
Query Neighborhood Hits	124	Target Neighborhood Hits	901	Shared Neighborhood Hits	9
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.071696 (rank : 87)
Query Neighborhood Hits	124	Target Neighborhood Hits	891	Shared Neighborhood Hits	9
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD2_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.071940 (rank : 83)
Query Neighborhood Hits	124	Target Neighborhood Hits	910	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCD3_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.072084 (rank : 82)
Query Neighborhood Hits	124	Target Neighborhood Hits	895	Shared Neighborhood Hits	11
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.072363 (rank : 80)
Query Neighborhood Hits	124	Target Neighborhood Hits	901	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCD_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.052536 (rank : 398)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	9
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCE_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.059566 (rank : 241)
Query Neighborhood Hits	124	Target Neighborhood Hits	906	Shared Neighborhood Hits	12
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.059074 (rank : 257)
Query Neighborhood Hits	124	Target Neighborhood Hits	906	Shared Neighborhood Hits	11
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCG_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.053261 (rank : 378)
Query Neighborhood Hits	124	Target Neighborhood Hits	1126	Shared Neighborhood Hits	14
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.053344 (rank : 374)
Query Neighborhood Hits	124	Target Neighborhood Hits	1123	Shared Neighborhood Hits	14
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCI_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.054538 (rank : 342)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	9
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.054547 (rank : 341)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	9
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCL_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.060379 (rank : 229)
Query Neighborhood Hits	124	Target Neighborhood Hits	887	Shared Neighborhood Hits	10
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.059323 (rank : 247)
Query Neighborhood Hits	124	Target Neighborhood Hits	891	Shared Neighborhood Hits	10
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCT_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.051146 (rank : 432)
Query Neighborhood Hits	124	Target Neighborhood Hits	897	Shared Neighborhood Hits	9
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.050385 (rank : 453)
Query Neighborhood Hits	124	Target Neighborhood Hits	895	Shared Neighborhood Hits	9
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCZ_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.054174 (rank : 353)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	9
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.054220 (rank : 352)
Query Neighborhood Hits	124	Target Neighborhood Hits	882	Shared Neighborhood Hits	9
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPSH1_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.081009 (rank : 46)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.080917 (rank : 48)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.083366 (rank : 32)
Query Neighborhood Hits	124	Target Neighborhood Hits	822	Shared Neighborhood Hits	9
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.066869 (rank : 145)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.070128 (rank : 101)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.068130 (rank : 133)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.069374 (rank : 113)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.068873 (rank : 122)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	10
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.068863 (rank : 123)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	10
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A4_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.064383 (rank : 182)
Query Neighborhood Hits	124	Target Neighborhood Hits	868	Shared Neighborhood Hits	11
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.064982 (rank : 173)
Query Neighborhood Hits	124	Target Neighborhood Hits	866	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KS6A5_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.064059 (rank : 185)
Query Neighborhood Hits	124	Target Neighborhood Hits	855	Shared Neighborhood Hits	9
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A5_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.058925 (rank : 261)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

KS6A6_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.069396 (rank : 112)
Query Neighborhood Hits	124	Target Neighborhood Hits	853	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.059104 (rank : 255)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.059128 (rank : 253)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.058661 (rank : 268)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KS6B2_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.060045 (rank : 236)
Query Neighborhood Hits	124	Target Neighborhood Hits	871	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

LATS1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.050822 (rank : 440)
Query Neighborhood Hits	124	Target Neighborhood Hits	1057	Shared Neighborhood Hits	17
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.051222 (rank : 429)
Query Neighborhood Hits	124	Target Neighborhood Hits	1027	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

LATS2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.050087 (rank : 458)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.053092 (rank : 384)
Query Neighborhood Hits	124	Target Neighborhood Hits	879	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

M3K2_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.055435 (rank : 324)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.056611 (rank : 302)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.052663 (rank : 395)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	12
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.052491 (rank : 400)
Query Neighborhood Hits	124	Target Neighborhood Hits	876	Shared Neighborhood Hits	11
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.050576 (rank : 446)
Query Neighborhood Hits	124	Target Neighborhood Hits	911	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.050553 (rank : 447)
Query Neighborhood Hits	124	Target Neighborhood Hits	924	Shared Neighborhood Hits	15
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K6_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.053988 (rank : 359)
Query Neighborhood Hits	124	Target Neighborhood Hits	889	Shared Neighborhood Hits	11
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K7_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.050115 (rank : 456)
Query Neighborhood Hits	124	Target Neighborhood Hits	892	Shared Neighborhood Hits	9
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.050193 (rank : 455)
Query Neighborhood Hits	124	Target Neighborhood Hits	892	Shared Neighborhood Hits	9
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.055862 (rank : 316)
Query Neighborhood Hits	124	Target Neighborhood Hits	807	Shared Neighborhood Hits	8
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.054669 (rank : 335)
Query Neighborhood Hits	124	Target Neighborhood Hits	815	Shared Neighborhood Hits	8
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MAK_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.050489 (rank : 449)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.051180 (rank : 431)
Query Neighborhood Hits	124	Target Neighborhood Hits	873	Shared Neighborhood Hits	11
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAPK2_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.081689 (rank : 41)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	10
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.082035 (rank : 40)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	9
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.082750 (rank : 37)
Query Neighborhood Hits	124	Target Neighborhood Hits	807	Shared Neighborhood Hits	9
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAPK3_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.081247 (rank : 45)
Query Neighborhood Hits	124	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAPK5_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.092070 (rank : 18)
Query Neighborhood Hits	124	Target Neighborhood Hits	795	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.091395 (rank : 19)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	8
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARK1_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.064840 (rank : 176)
Query Neighborhood Hits	124	Target Neighborhood Hits	887	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.064307 (rank : 184)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.066803 (rank : 146)
Query Neighborhood Hits	124	Target Neighborhood Hits	1056	Shared Neighborhood Hits	32
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK3_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.066012 (rank : 161)
Query Neighborhood Hits	124	Target Neighborhood Hits	893	Shared Neighborhood Hits	15
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.064623 (rank : 177)
Query Neighborhood Hits	124	Target Neighborhood Hits	919	Shared Neighborhood Hits	20
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.065164 (rank : 170)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	12
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.064964 (rank : 174)
Query Neighborhood Hits	124	Target Neighborhood Hits	898	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MAST1_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.060110 (rank : 235)
Query Neighborhood Hits	124	Target Neighborhood Hits	1146	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.059041 (rank : 258)
Query Neighborhood Hits	124	Target Neighborhood Hits	1123	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.060460 (rank : 228)
Query Neighborhood Hits	124	Target Neighborhood Hits	1189	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.061173 (rank : 219)
Query Neighborhood Hits	124	Target Neighborhood Hits	1110	Shared Neighborhood Hits	29
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.058282 (rank : 275)
Query Neighborhood Hits	124	Target Neighborhood Hits	1128	Shared Neighborhood Hits	22
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MASTL_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.056734 (rank : 299)
Query Neighborhood Hits	124	Target Neighborhood Hits	894	Shared Neighborhood Hits	9
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.058145 (rank : 278)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MELK_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.071749 (rank : 86)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	10
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.070369 (rank : 99)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	9
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MK01_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.052971 (rank : 390)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.052987 (rank : 389)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.053011 (rank : 387)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.053473 (rank : 371)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.059105 (rank : 254)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	10
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.059151 (rank : 252)
Query Neighborhood Hits	124	Target Neighborhood Hits	852	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK06_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.055325 (rank : 325)
Query Neighborhood Hits	124	Target Neighborhood Hits	815	Shared Neighborhood Hits	9
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.055816 (rank : 318)
Query Neighborhood Hits	124	Target Neighborhood Hits	818	Shared Neighborhood Hits	9
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK07_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.054322 (rank : 350)
Query Neighborhood Hits	124	Target Neighborhood Hits	1054	Shared Neighborhood Hits	17
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK08_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.052814 (rank : 392)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.052859 (rank : 391)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK09_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.054328 (rank : 348)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK09_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.052370 (rank : 402)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK11_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.050443 (rank : 450)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK12_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.054326 (rank : 349)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.052099 (rank : 408)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK13_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.053618 (rank : 367)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.054347 (rank : 347)
Query Neighborhood Hits	124	Target Neighborhood Hits	832	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.053529 (rank : 369)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.053623 (rank : 366)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK15_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.054963 (rank : 328)
Query Neighborhood Hits	124	Target Neighborhood Hits	1038	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK15_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.050385 (rank : 452)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	10
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MKNK1_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.096418 (rank : 15)
Query Neighborhood Hits	124	Target Neighborhood Hits	701	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK1_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.084493 (rank : 26)
Query Neighborhood Hits	124	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.085262 (rank : 23)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.084972 (rank : 24)
Query Neighborhood Hits	124	Target Neighborhood Hits	819	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MOK_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.056168 (rank : 306)
Query Neighborhood Hits	124	Target Neighborhood Hits	807	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MOK_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.054734 (rank : 333)
Query Neighborhood Hits	124	Target Neighborhood Hits	796	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.050024 (rank : 459)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYLK2_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.073446 (rank : 76)
Query Neighborhood Hits	124	Target Neighborhood Hits	920	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYLK_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.067238 (rank : 144)
Query Neighborhood Hits	124	Target Neighborhood Hits	1328	Shared Neighborhood Hits	21
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.068884 (rank : 120)
Query Neighborhood Hits	124	Target Neighborhood Hits	1489	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NEK1_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.056151 (rank : 307)
Query Neighborhood Hits	124	Target Neighborhood Hits	1129	Shared Neighborhood Hits	15
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.057229 (rank : 291)
Query Neighborhood Hits	124	Target Neighborhood Hits	1311	Shared Neighborhood Hits	26
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.065132 (rank : 171)
Query Neighborhood Hits	124	Target Neighborhood Hits	908	Shared Neighborhood Hits	9
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.065198 (rank : 169)
Query Neighborhood Hits	124	Target Neighborhood Hits	876	Shared Neighborhood Hits	9
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.054155 (rank : 354)
Query Neighborhood Hits	124	Target Neighborhood Hits	865	Shared Neighborhood Hits	9
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.054896 (rank : 329)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.054850 (rank : 330)
Query Neighborhood Hits	124	Target Neighborhood Hits	883	Shared Neighborhood Hits	9
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.054642 (rank : 337)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.057256 (rank : 290)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.057419 (rank : 287)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.054518 (rank : 343)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.053610 (rank : 368)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.056619 (rank : 301)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	11
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.057171 (rank : 292)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	11
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NIM1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.069475 (rank : 111)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.069906 (rank : 107)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NLK_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.050859 (rank : 438)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.050858 (rank : 439)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NUAK1_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.064593 (rank : 178)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	13
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.064391 (rank : 181)
Query Neighborhood Hits	124	Target Neighborhood Hits	881	Shared Neighborhood Hits	11
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.061094 (rank : 222)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.062174 (rank : 210)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

OBSCN_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.061641 (rank : 216)
Query Neighborhood Hits	124	Target Neighborhood Hits	1931	Shared Neighborhood Hits	36
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OXSR1_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.052529 (rank : 399)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	11
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.052101 (rank : 407)
Query Neighborhood Hits	124	Target Neighborhood Hits	865	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.059188 (rank : 249)
Query Neighborhood Hits	124	Target Neighborhood Hits	873	Shared Neighborhood Hits	11
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.059166 (rank : 251)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	12
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.059412 (rank : 243)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	11
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.059411 (rank : 244)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.060195 (rank : 230)
Query Neighborhood Hits	124	Target Neighborhood Hits	887	Shared Neighborhood Hits	12
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.060186 (rank : 233)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	12
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.058899 (rank : 262)
Query Neighborhood Hits	124	Target Neighborhood Hits	924	Shared Neighborhood Hits	17
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.060807 (rank : 226)
Query Neighborhood Hits	124	Target Neighborhood Hits	1098	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.058309 (rank : 274)
Query Neighborhood Hits	124	Target Neighborhood Hits	915	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.058111 (rank : 279)
Query Neighborhood Hits	124	Target Neighborhood Hits	875	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.058242 (rank : 277)
Query Neighborhood Hits	124	Target Neighborhood Hits	875	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PASK_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.065774 (rank : 165)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PASK_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.063903 (rank : 186)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PDK1L_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.070060 (rank : 103)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.070000 (rank : 106)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDPK1_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.060194 (rank : 231)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	9
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.059828 (rank : 238)
Query Neighborhood Hits	124	Target Neighborhood Hits	852	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PFTK1_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.053105 (rank : 383)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.053310 (rank : 377)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PHKG1_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.079594 (rank : 50)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG1_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.081492 (rank : 42)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.078526 (rank : 52)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG2_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.078561 (rank : 51)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PIM1_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.071397 (rank : 91)
Query Neighborhood Hits	124	Target Neighborhood Hits	797	Shared Neighborhood Hits	9
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.070814 (rank : 95)
Query Neighborhood Hits	124	Target Neighborhood Hits	787	Shared Neighborhood Hits	9
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.068691 (rank : 124)
Query Neighborhood Hits	124	Target Neighborhood Hits	808	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PIM2_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.070018 (rank : 105)
Query Neighborhood Hits	124	Target Neighborhood Hits	809	Shared Neighborhood Hits	9
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PIM3_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.071586 (rank : 89)
Query Neighborhood Hits	124	Target Neighborhood Hits	789	Shared Neighborhood Hits	9
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.071842 (rank : 85)
Query Neighborhood Hits	124	Target Neighborhood Hits	783	Shared Neighborhood Hits	9
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PINK1_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.051666 (rank : 417)
Query Neighborhood Hits	124	Target Neighborhood Hits	741	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.051888 (rank : 413)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	11
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.052484 (rank : 401)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	9
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.052235 (rank : 405)
Query Neighborhood Hits	124	Target Neighborhood Hits	892	Shared Neighborhood Hits	9
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.052748 (rank : 393)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.053339 (rank : 375)
Query Neighborhood Hits	124	Target Neighborhood Hits	893	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.055766 (rank : 319)
Query Neighborhood Hits	124	Target Neighborhood Hits	1009	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.061501 (rank : 217)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.062454 (rank : 205)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.061167 (rank : 220)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.061260 (rank : 218)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.063847 (rank : 187)
Query Neighborhood Hits	124	Target Neighborhood Hits	865	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.062496 (rank : 204)
Query Neighborhood Hits	124	Target Neighborhood Hits	863	Shared Neighborhood Hits	10
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.066307 (rank : 153)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	10
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.065970 (rank : 162)
Query Neighborhood Hits	124	Target Neighborhood Hits	879	Shared Neighborhood Hits	12
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PRKX_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.065500 (rank : 167)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.064347 (rank : 183)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.066068 (rank : 160)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	9
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

RK_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.055927 (rank : 314)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RK_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.056943 (rank : 298)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ROCK2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.050311 (rank : 454)
Query Neighborhood Hits	124	Target Neighborhood Hits	2073	Shared Neighborhood Hits	24
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SBK1_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.071123 (rank : 94)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	12
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.069521 (rank : 109)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.062879 (rank : 196)
Query Neighborhood Hits	124	Target Neighborhood Hits	632	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.058892 (rank : 264)
Query Neighborhood Hits	124	Target Neighborhood Hits	603	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SGK1_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.059416 (rank : 242)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.060193 (rank : 232)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.060119 (rank : 234)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK2_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.058979 (rank : 260)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.057913 (rank : 282)
Query Neighborhood Hits	124	Target Neighborhood Hits	877	Shared Neighborhood Hits	9
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.057711 (rank : 283)
Query Neighborhood Hits	124	Target Neighborhood Hits	882	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SN1L1_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.069271 (rank : 115)
Query Neighborhood Hits	124	Target Neighborhood Hits	911	Shared Neighborhood Hits	11
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.068348 (rank : 129)
Query Neighborhood Hits	124	Target Neighborhood Hits	895	Shared Neighborhood Hits	12
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.067655 (rank : 139)
Query Neighborhood Hits	124	Target Neighborhood Hits	964	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.067783 (rank : 138)
Query Neighborhood Hits	124	Target Neighborhood Hits	944	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNRK_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.067455 (rank : 140)
Query Neighborhood Hits	124	Target Neighborhood Hits	855	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.067245 (rank : 143)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SPEG_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.066555 (rank : 151)
Query Neighborhood Hits	124	Target Neighborhood Hits	1762	Shared Neighborhood Hits	47
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.070402 (rank : 98)
Query Neighborhood Hits	124	Target Neighborhood Hits	1959	Shared Neighborhood Hits	46
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ST17A_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.073768 (rank : 74)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.070096 (rank : 102)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.069511 (rank : 110)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST32A_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.058567 (rank : 269)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

ST32A_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.060537 (rank : 227)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ST32B_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.060982 (rank : 224)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.061140 (rank : 221)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.061799 (rank : 214)
Query Neighborhood Hits	124	Target Neighborhood Hits	832	Shared Neighborhood Hits	9
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.062340 (rank : 209)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST38L_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.061883 (rank : 213)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.063218 (rank : 191)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK11_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.070708 (rank : 96)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	9
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK16_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.051123 (rank : 435)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.054096 (rank : 355)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK33_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.075573 (rank : 65)
Query Neighborhood Hits	124	Target Neighborhood Hits	879	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.070416 (rank : 97)
Query Neighborhood Hits	124	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.056993 (rank : 296)
Query Neighborhood Hits	124	Target Neighborhood Hits	896	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.056969 (rank : 297)
Query Neighborhood Hits	124	Target Neighborhood Hits	877	Shared Neighborhood Hits	9
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK38_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.062394 (rank : 207)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.062042 (rank : 212)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK39_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.051277 (rank : 428)
Query Neighborhood Hits	124	Target Neighborhood Hits	882	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.051387 (rank : 423)
Query Neighborhood Hits	124	Target Neighborhood Hits	915	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK40_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.059016 (rank : 259)
Query Neighborhood Hits	124	Target Neighborhood Hits	751	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.058785 (rank : 266)
Query Neighborhood Hits	124	Target Neighborhood Hits	751	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK4_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.050424 (rank : 451)
Query Neighborhood Hits	124	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.050108 (rank : 457)
Query Neighborhood Hits	124	Target Neighborhood Hits	873	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.065105 (rank : 172)
Query Neighborhood Hits	124	Target Neighborhood Hits	916	Shared Neighborhood Hits	13
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.065355 (rank : 168)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	10
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TBK1_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.059594 (rank : 240)
Query Neighborhood Hits	124	Target Neighborhood Hits	861	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.059675 (rank : 239)
Query Neighborhood Hits	124	Target Neighborhood Hits	893	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TESK1_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.051711 (rank : 415)
Query Neighborhood Hits	124	Target Neighborhood Hits	864	Shared Neighborhood Hits	12
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.051525 (rank : 420)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	10
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TITIN_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.063029 (rank : 194)
Query Neighborhood Hits	124	Target Neighborhood Hits	2923	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TLK1_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.067957 (rank : 135)
Query Neighborhood Hits	124	Target Neighborhood Hits	967	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.067874 (rank : 136)
Query Neighborhood Hits	124	Target Neighborhood Hits	947	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.062442 (rank : 206)
Query Neighborhood Hits	124	Target Neighborhood Hits	1044	Shared Neighborhood Hits	12
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.062136 (rank : 211)
Query Neighborhood Hits	124	Target Neighborhood Hits	1088	Shared Neighborhood Hits	11
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TRIB1_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.075470 (rank : 66)
Query Neighborhood Hits	124	Target Neighborhood Hits	598	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.075432 (rank : 67)
Query Neighborhood Hits	124	Target Neighborhood Hits	593	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.078176 (rank : 54)
Query Neighborhood Hits	124	Target Neighborhood Hits	657	Shared Neighborhood Hits	8
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.078137 (rank : 55)
Query Neighborhood Hits	124	Target Neighborhood Hits	653	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.078202 (rank : 53)
Query Neighborhood Hits	124	Target Neighborhood Hits	519	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.073560 (rank : 75)
Query Neighborhood Hits	124	Target Neighborhood Hits	578	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.071235 (rank : 92)
Query Neighborhood Hits	124	Target Neighborhood Hits	1580	Shared Neighborhood Hits	23
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSSK1_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.071562 (rank : 90)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.069278 (rank : 114)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.070041 (rank : 104)
Query Neighborhood Hits	124	Target Neighborhood Hits	826	Shared Neighborhood Hits	9
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.071193 (rank : 93)
Query Neighborhood Hits	124	Target Neighborhood Hits	819	Shared Neighborhood Hits	9
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK3_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.075342 (rank : 69)
Query Neighborhood Hits	124	Target Neighborhood Hits	806	Shared Neighborhood Hits	9
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.075716 (rank : 64)
Query Neighborhood Hits	124	Target Neighborhood Hits	806	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK4_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.062812 (rank : 200)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.062390 (rank : 208)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.069121 (rank : 117)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.068433 (rank : 128)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTBK1_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.054629 (rank : 338)
Query Neighborhood Hits	124	Target Neighborhood Hits	1058	Shared Neighborhood Hits	25
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.057318 (rank : 289)
Query Neighborhood Hits	124	Target Neighborhood Hits	822	Shared Neighborhood Hits	18
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.056280 (rank : 305)
Query Neighborhood Hits	124	Target Neighborhood Hits	811	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTK_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.052164 (rank : 406)
Query Neighborhood Hits	124	Target Neighborhood Hits	816	Shared Neighborhood Hits	10
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.051283 (rank : 427)
Query Neighborhood Hits	124	Target Neighborhood Hits	803	Shared Neighborhood Hits	11
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

ULK1_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.062648 (rank : 202)
Query Neighborhood Hits	124	Target Neighborhood Hits	1121	Shared Neighborhood Hits	25
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.062947 (rank : 195)
Query Neighborhood Hits	124	Target Neighborhood Hits	1214	Shared Neighborhood Hits	41
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.064520 (rank : 179)
Query Neighborhood Hits	124	Target Neighborhood Hits	979	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.062839 (rank : 199)
Query Neighborhood Hits	124	Target Neighborhood Hits	943	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.060003 (rank : 237)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.059338 (rank : 246)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK4_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.062636 (rank : 203)
Query Neighborhood Hits	124	Target Neighborhood Hits	793	Shared Neighborhood Hits	9
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

WEE1B_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.076047 (rank : 63)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	19
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1B_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.069209 (rank : 116)
Query Neighborhood Hits	124	Target Neighborhood Hits	765	Shared Neighborhood Hits	11
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

WEE1_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.072572 (rank : 78)
Query Neighborhood Hits	124	Target Neighborhood Hits	777	Shared Neighborhood Hits	10
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WEE1_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.072302 (rank : 81)
Query Neighborhood Hits	124	Target Neighborhood Hits	794	Shared Neighborhood Hits	9
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

WNK1_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.053167 (rank : 381)
Query Neighborhood Hits	124	Target Neighborhood Hits	1158	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.053331 (rank : 376)
Query Neighborhood Hits	124	Target Neighborhood Hits	1179	Shared Neighborhood Hits	26
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.054652 (rank : 336)
Query Neighborhood Hits	124	Target Neighborhood Hits	1407	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.051603 (rank : 418)
Query Neighborhood Hits	124	Target Neighborhood Hits	948	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK4_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.055840 (rank : 317)
Query Neighborhood Hits	124	Target Neighborhood Hits	1043	Shared Neighborhood Hits	27
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.055018 (rank : 327)
Query Neighborhood Hits	124	Target Neighborhood Hits	961	Shared Neighborhood Hits	21
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

YSK4_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.050494 (rank : 448)
Query Neighborhood Hits	124	Target Neighborhood Hits	921	Shared Neighborhood Hits	10
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

Hits sorted by NC score

DCX_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	124
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_HUMAN
NC score	0.987987 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	124	Target Neighborhood Hits	141	Shared Neighborhood Hits	79
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCDC2_HUMAN
NC score	0.706229 (rank : 3)	θ value	2.97466e-19 (rank : 9)
Query Neighborhood Hits	124	Target Neighborhood Hits	127	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UHG0, Q5VTR8, Q5VTR9, Q86W35, Q9UFD1, Q9ULR6	Gene names	DCDC2, KIAA1154
Domain Architecture
Description	Doublecortin domain-containing protein 2 (RU2S protein).

DCDC2_MOUSE
NC score	0.670711 (rank : 4)	θ value	3.51386e-20 (rank : 7)
Query Neighborhood Hits	124	Target Neighborhood Hits	247	Shared Neighborhood Hits	19
SwissProt Accessions	Q5DU00, Q5SZU0, Q80Y99	Gene names	Dcdc2, Kiaa1154
Domain Architecture	No domain graphic available
Description	Doublecortin domain-containing protein 2.

RP1_HUMAN
NC score	0.619402 (rank : 5)	θ value	1.02238e-19 (rank : 8)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	P56715	Gene names	RP1, ORP1
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein) (Retinitis pigmentosa 1 protein).

RP1_MOUSE
NC score	0.613737 (rank : 6)	θ value	3.28887e-18 (rank : 10)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	P56716	Gene names	Rp1, Orp1, Rp1h
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog).

RP1L1_MOUSE
NC score	0.595913 (rank : 7)	θ value	8.10077e-17 (rank : 11)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

RP1L1_HUMAN
NC score	0.395799 (rank : 8)	θ value	4.44505e-15 (rank : 12)
Query Neighborhood Hits	124	Target Neighborhood Hits	1072	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

DCAK1_MOUSE
NC score	0.242629 (rank : 9)	θ value	1.2462e-142 (rank : 4)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_HUMAN
NC score	0.242290 (rank : 10)	θ value	9.54178e-143 (rank : 3)
Query Neighborhood Hits	124	Target Neighborhood Hits	877	Shared Neighborhood Hits	24
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
NC score	0.241611 (rank : 11)	θ value	3.4016e-132 (rank : 5)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
NC score	0.240057 (rank : 12)	θ value	9.26343e-130 (rank : 6)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

CAMKV_HUMAN
NC score	0.104018 (rank : 13)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	124	Target Neighborhood Hits	1084	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
NC score	0.100111 (rank : 14)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	16
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MKNK1_HUMAN
NC score	0.096418 (rank : 15)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	124	Target Neighborhood Hits	701	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

DCAK3_HUMAN
NC score	0.095042 (rank : 16)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	12
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
NC score	0.093711 (rank : 17)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	124	Target Neighborhood Hits	922	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

MAPK5_HUMAN
NC score	0.092070 (rank : 18)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	124	Target Neighborhood Hits	795	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
NC score	0.091395 (rank : 19)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	8
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARCS_HUMAN
NC score	0.089047 (rank : 20)	θ value	0.0736092 (rank : 18)
Query Neighborhood Hits	124	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

KCC1B_HUMAN
NC score	0.085368 (rank : 21)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
NC score	0.085309 (rank : 22)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

MKNK2_HUMAN
NC score	0.085262 (rank : 23)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
NC score	0.084972 (rank : 24)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	124	Target Neighborhood Hits	819	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KCC4_HUMAN
NC score	0.084823 (rank : 25)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	9
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MKNK1_MOUSE
NC score	0.084493 (rank : 26)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	124	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

KCC2B_HUMAN
NC score	0.084359 (rank : 27)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	124	Target Neighborhood Hits	866	Shared Neighborhood Hits	13
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC4_MOUSE
NC score	0.084339 (rank : 28)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	9
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC2B_MOUSE
NC score	0.084128 (rank : 29)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	11
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC1A_MOUSE
NC score	0.083998 (rank : 30)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	124	Target Neighborhood Hits	845	Shared Neighborhood Hits	9
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_HUMAN
NC score	0.083816 (rank : 31)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KPSH2_HUMAN
NC score	0.083366 (rank : 32)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	124	Target Neighborhood Hits	822	Shared Neighborhood Hits	9
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KCC2A_MOUSE
NC score	0.083026 (rank : 33)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC1D_MOUSE
NC score	0.082939 (rank : 34)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.082916 (rank : 35)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC2A_HUMAN
NC score	0.082844 (rank : 36)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

MAPK3_HUMAN
NC score	0.082750 (rank : 37)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	124	Target Neighborhood Hits	807	Shared Neighborhood Hits	9
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

KCC2G_HUMAN
NC score	0.082650 (rank : 38)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	9
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
NC score	0.082649 (rank : 39)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

MAPK2_MOUSE
NC score	0.082035 (rank : 40)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	9
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_HUMAN
NC score	0.081689 (rank : 41)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	10
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

PHKG1_MOUSE
NC score	0.081492 (rank : 42)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

KCC2D_HUMAN
NC score	0.081395 (rank : 43)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

K2002_HUMAN
NC score	0.081312 (rank : 44)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	124	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MAPK3_MOUSE
NC score	0.081247 (rank : 45)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	124	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

KPSH1_HUMAN
NC score	0.081009 (rank : 46)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC1G_MOUSE
NC score	0.080925 (rank : 47)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	10
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KPSH1_MOUSE
NC score	0.080917 (rank : 48)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC1G_HUMAN
NC score	0.080755 (rank : 49)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	10
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

PHKG1_HUMAN
NC score	0.079594 (rank : 50)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_MOUSE
NC score	0.078561 (rank : 51)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	124	Target Neighborhood Hits	841	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PHKG2_HUMAN
NC score	0.078526 (rank : 52)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

TRIB3_HUMAN
NC score	0.078202 (rank : 53)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	124	Target Neighborhood Hits	519	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB2_HUMAN
NC score	0.078176 (rank : 54)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	124	Target Neighborhood Hits	657	Shared Neighborhood Hits	8
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.078137 (rank : 55)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	124	Target Neighborhood Hits	653	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

DAPK2_HUMAN
NC score	0.077417 (rank : 56)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	124	Target Neighborhood Hits	832	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
NC score	0.077343 (rank : 57)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

CHK2_HUMAN
NC score	0.077168 (rank : 58)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	9
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

DAPK3_HUMAN
NC score	0.077156 (rank : 59)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	124	Target Neighborhood Hits	945	Shared Neighborhood Hits	9
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
NC score	0.076909 (rank : 60)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

CHK2_MOUSE
NC score	0.076248 (rank : 61)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

DUET_HUMAN
NC score	0.076192 (rank : 62)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	124	Target Neighborhood Hits	1220	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

WEE1B_HUMAN
NC score	0.076047 (rank : 63)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	19
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

TSSK3_MOUSE
NC score	0.075716 (rank : 64)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	124	Target Neighborhood Hits	806	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

STK33_HUMAN
NC score	0.075573 (rank : 65)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	124	Target Neighborhood Hits	879	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

TRIB1_HUMAN
NC score	0.075470 (rank : 66)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	124	Target Neighborhood Hits	598	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
NC score	0.075432 (rank : 67)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	124	Target Neighborhood Hits	593	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

CLK3_HUMAN
NC score	0.075343 (rank : 68)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	124	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

TSSK3_HUMAN
NC score	0.075342 (rank : 69)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	124	Target Neighborhood Hits	806	Shared Neighborhood Hits	9
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CLK3_MOUSE
NC score	0.075340 (rank : 70)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	124	Target Neighborhood Hits	761	Shared Neighborhood Hits	9
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

TMM24_MOUSE
NC score	0.074776 (rank : 71)	θ value	0.00665767 (rank : 15)
Query Neighborhood Hits	124	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q80X80	Gene names	Tmem24
Domain Architecture	No domain graphic available
Description	Transmembrane protein 24.

CSKP_MOUSE
NC score	0.074371 (rank : 72)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	124	Target Neighborhood Hits	1027	Shared Neighborhood Hits	10
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSKP_HUMAN
NC score	0.074146 (rank : 73)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	124	Target Neighborhood Hits	1022	Shared Neighborhood Hits	10
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

ST17A_HUMAN
NC score	0.073768 (rank : 74)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

TRIB3_MOUSE
NC score	0.073560 (rank : 75)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	124	Target Neighborhood Hits	578	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

MYLK2_HUMAN
NC score	0.073446 (rank : 76)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	124	Target Neighborhood Hits	920	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYCB2_MOUSE
NC score	0.073354 (rank : 77)	θ value	0.00390308 (rank : 13)
Query Neighborhood Hits	124	Target Neighborhood Hits	307	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

WEE1_HUMAN
NC score	0.072572 (rank : 78)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	124	Target Neighborhood Hits	777	Shared Neighborhood Hits	10
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

CLK2_HUMAN
NC score	0.072457 (rank : 79)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	124	Target Neighborhood Hits	752	Shared Neighborhood Hits	9
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

KPCD3_MOUSE
NC score	0.072363 (rank : 80)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	124	Target Neighborhood Hits	901	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

WEE1_MOUSE
NC score	0.072302 (rank : 81)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	124	Target Neighborhood Hits	794	Shared Neighborhood Hits	9
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

KPCD3_HUMAN
NC score	0.072084 (rank : 82)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	124	Target Neighborhood Hits	895	Shared Neighborhood Hits	11
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD2_HUMAN
NC score	0.071940 (rank : 83)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	124	Target Neighborhood Hits	910	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

CLK2_MOUSE
NC score	0.071846 (rank : 84)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	124	Target Neighborhood Hits	743	Shared Neighborhood Hits	9
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

PIM3_MOUSE
NC score	0.071842 (rank : 85)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	124	Target Neighborhood Hits	783	Shared Neighborhood Hits	9
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

MELK_HUMAN
NC score	0.071749 (rank : 86)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	10
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

KPCD1_MOUSE
NC score	0.071696 (rank : 87)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	124	Target Neighborhood Hits	891	Shared Neighborhood Hits	9
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_HUMAN
NC score	0.071632 (rank : 88)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	124	Target Neighborhood Hits	901	Shared Neighborhood Hits	9
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PIM3_HUMAN
NC score	0.071586 (rank : 89)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	124	Target Neighborhood Hits	789	Shared Neighborhood Hits	9
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

TSSK1_HUMAN
NC score	0.071562 (rank : 90)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

PIM1_HUMAN
NC score	0.071397 (rank : 91)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	124	Target Neighborhood Hits	797	Shared Neighborhood Hits	9
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TRIO_HUMAN
NC score	0.071235 (rank : 92)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	124	Target Neighborhood Hits	1580	Shared Neighborhood Hits	23
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSSK2_MOUSE
NC score	0.071193 (rank : 93)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	124	Target Neighborhood Hits	819	Shared Neighborhood Hits	9
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

SBK1_HUMAN
NC score	0.071123 (rank : 94)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	12
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

PIM1_MOUSE
NC score	0.070814 (rank : 95)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	124	Target Neighborhood Hits	787	Shared Neighborhood Hits	9
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

STK11_HUMAN
NC score	0.070708 (rank : 96)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	9
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK35_HUMAN
NC score	0.070416 (rank : 97)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	124	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

SPEG_MOUSE
NC score	0.070402 (rank : 98)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	124	Target Neighborhood Hits	1959	Shared Neighborhood Hits	46
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MELK_MOUSE
NC score	0.070369 (rank : 99)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	9
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

UBN1_HUMAN
NC score	0.070289 (rank : 100)	θ value	0.163984 (rank : 22)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

KS6A1_MOUSE
NC score	0.070128 (rank : 101)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

ST17B_HUMAN
NC score	0.070096 (rank : 102)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

PDK1L_HUMAN
NC score	0.070060 (rank : 103)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

TSSK2_HUMAN
NC score	0.070041 (rank : 104)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	124	Target Neighborhood Hits	826	Shared Neighborhood Hits	9
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

PIM2_MOUSE
NC score	0.070018 (rank : 105)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	124	Target Neighborhood Hits	809	Shared Neighborhood Hits	9
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PDK1L_MOUSE
NC score	0.070000 (rank : 106)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

NIM1_MOUSE
NC score	0.069906 (rank : 107)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

DAPK1_HUMAN
NC score	0.069710 (rank : 108)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	124	Target Neighborhood Hits	1130	Shared Neighborhood Hits	10
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

SBK1_MOUSE
NC score	0.069521 (rank : 109)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

ST17B_MOUSE
NC score	0.069511 (rank : 110)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

NIM1_HUMAN
NC score	0.069475 (rank : 111)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KS6A6_HUMAN
NC score	0.069396 (rank : 112)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	124	Target Neighborhood Hits	853	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6A2_MOUSE
NC score	0.069374 (rank : 113)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

TSSK1_MOUSE
NC score	0.069278 (rank : 114)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

SN1L1_HUMAN
NC score	0.069271 (rank : 115)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	124	Target Neighborhood Hits	911	Shared Neighborhood Hits	11
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

WEE1B_MOUSE
NC score	0.069209 (rank : 116)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	124	Target Neighborhood Hits	765	Shared Neighborhood Hits	11
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

TSSK6_HUMAN
NC score	0.069121 (rank : 117)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

DAPK1_MOUSE
NC score	0.068986 (rank : 118)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	124	Target Neighborhood Hits	1138	Shared Neighborhood Hits	10
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DCDC1_HUMAN
NC score	0.068962 (rank : 119)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	124	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P59894	Gene names	DCDC1
Domain Architecture	No domain graphic available
Description	Doublecortin domain-containing protein 1.

MYLK_MOUSE
NC score	0.068884 (rank : 120)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	124	Target Neighborhood Hits	1489	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

KKCC1_MOUSE
NC score	0.068881 (rank : 121)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	124	Target Neighborhood Hits	866	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KS6A3_HUMAN
NC score	0.068873 (rank : 122)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	10
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
NC score	0.068863 (rank : 123)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	10
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PIM2_HUMAN
NC score	0.068691 (rank : 124)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	124	Target Neighborhood Hits	808	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

KKCC2_HUMAN
NC score	0.068655 (rank : 125)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	124	Target Neighborhood Hits	852	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

K0999_MOUSE
NC score	0.068572 (rank : 126)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	124	Target Neighborhood Hits	931	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KKCC2_MOUSE
NC score	0.068523 (rank : 127)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	124	Target Neighborhood Hits	855	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

TSSK6_MOUSE
NC score	0.068433 (rank : 128)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

SN1L1_MOUSE
NC score	0.068348 (rank : 129)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	124	Target Neighborhood Hits	895	Shared Neighborhood Hits	12
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

KKCC1_HUMAN
NC score	0.068338 (rank : 130)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MARK2_MOUSE
NC score	0.068321 (rank : 131)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	124	Target Neighborhood Hits	1018	Shared Neighborhood Hits	30
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

K0999_HUMAN
NC score	0.068167 (rank : 132)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KS6A2_HUMAN
NC score	0.068130 (rank : 133)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

AAPK2_HUMAN
NC score	0.067963 (rank : 134)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

TLK1_HUMAN
NC score	0.067957 (rank : 135)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	124	Target Neighborhood Hits	967	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
NC score	0.067874 (rank : 136)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	124	Target Neighborhood Hits	947	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

GAK_HUMAN
NC score	0.067806 (rank : 137)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	124	Target Neighborhood Hits	1028	Shared Neighborhood Hits	24
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

SN1L2_MOUSE
NC score	0.067783 (rank : 138)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	124	Target Neighborhood Hits	944	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SN1L2_HUMAN
NC score	0.067655 (rank : 139)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	124	Target Neighborhood Hits	964	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SNRK_HUMAN
NC score	0.067455 (rank : 140)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	124	Target Neighborhood Hits	855	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MAST4_HUMAN
NC score	0.067424 (rank : 141)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	124	Target Neighborhood Hits	1804	Shared Neighborhood Hits	64
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

BRSK1_HUMAN
NC score	0.067271 (rank : 142)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	124	Target Neighborhood Hits	942	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

SNRK_MOUSE
NC score	0.067245 (rank : 143)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MYLK_HUMAN
NC score	0.067238 (rank : 144)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	124	Target Neighborhood Hits	1328	Shared Neighborhood Hits	21
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

KS6A1_HUMAN
NC score	0.066869 (rank : 145)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MARK2_HUMAN
NC score	0.066803 (rank : 146)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	124	Target Neighborhood Hits	1056	Shared Neighborhood Hits	32
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

AAPK1_HUMAN
NC score	0.066767 (rank : 147)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
NC score	0.066725 (rank : 148)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KAPCG_HUMAN
NC score	0.066676 (rank : 149)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	124	Target Neighborhood Hits	845	Shared Neighborhood Hits	9
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KAPCB_MOUSE
NC score	0.066567 (rank : 150)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

SPEG_HUMAN
NC score	0.066555 (rank : 151)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	124	Target Neighborhood Hits	1762	Shared Neighborhood Hits	47
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

GAK_MOUSE
NC score	0.066349 (rank : 152)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	124	Target Neighborhood Hits	964	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PLK4_HUMAN
NC score	0.066307 (rank : 153)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	10
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KAPCB_HUMAN
NC score	0.066249 (rank : 154)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCA_HUMAN
NC score	0.066174 (rank : 155)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

HUNK_MOUSE
NC score	0.066174 (rank : 156)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

HUNK_HUMAN
NC score	0.066121 (rank : 157)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	10
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

KAPCA_MOUSE
NC score	0.066093 (rank : 158)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

AURKB_HUMAN
NC score	0.066079 (rank : 159)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

PRKY_HUMAN
NC score	0.066068 (rank : 160)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	9
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

MARK3_HUMAN
NC score	0.066012 (rank : 161)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	124	Target Neighborhood Hits	893	Shared Neighborhood Hits	15
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PLK4_MOUSE
NC score	0.065970 (rank : 162)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	124	Target Neighborhood Hits	879	Shared Neighborhood Hits	12
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

F5006_HUMAN
NC score	0.065874 (rank : 163)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	124	Target Neighborhood Hits	794	Shared Neighborhood Hits	9
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

CHK1_MOUSE
NC score	0.065828 (rank : 164)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

PASK_HUMAN
NC score	0.065774 (rank : 165)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

CHK1_HUMAN
NC score	0.065740 (rank : 166)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

PRKX_HUMAN
NC score	0.065500 (rank : 167)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

STK6_MOUSE
NC score	0.065355 (rank : 168)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	10
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

NEK2_MOUSE
NC score	0.065198 (rank : 169)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	124	Target Neighborhood Hits	876	Shared Neighborhood Hits	9
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

MARK4_HUMAN
NC score	0.065164 (rank : 170)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	12
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

NEK2_HUMAN
NC score	0.065132 (rank : 171)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	124	Target Neighborhood Hits	908	Shared Neighborhood Hits	9
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

STK6_HUMAN
NC score	0.065105 (rank : 172)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	124	Target Neighborhood Hits	916	Shared Neighborhood Hits	13
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

KS6A4_MOUSE
NC score	0.064982 (rank : 173)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	124	Target Neighborhood Hits	866	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MARK4_MOUSE
NC score	0.064964 (rank : 174)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	124	Target Neighborhood Hits	898	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

BRSK2_HUMAN
NC score	0.064902 (rank : 175)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	124	Target Neighborhood Hits	897	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

MARK1_HUMAN
NC score	0.064840 (rank : 176)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	124	Target Neighborhood Hits	887	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK3_MOUSE
NC score	0.064623 (rank : 177)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	124	Target Neighborhood Hits	919	Shared Neighborhood Hits	20
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

NUAK1_HUMAN
NC score	0.064593 (rank : 178)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	13
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

ULK2_HUMAN
NC score	0.064520 (rank : 179)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	124	Target Neighborhood Hits	979	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

AURKB_MOUSE
NC score	0.064416 (rank : 180)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

NUAK1_MOUSE
NC score	0.064391 (rank : 181)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	124	Target Neighborhood Hits	881	Shared Neighborhood Hits	11
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

KS6A4_HUMAN
NC score	0.064383 (rank : 182)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	124	Target Neighborhood Hits	868	Shared Neighborhood Hits	11
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

PRKX_MOUSE
NC score	0.064347 (rank : 183)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

MARK1_MOUSE
NC score	0.064307 (rank : 184)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

KS6A5_HUMAN
NC score	0.064059 (rank : 185)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	124	Target Neighborhood Hits	855	Shared Neighborhood Hits	9
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

PASK_MOUSE
NC score	0.063903 (rank : 186)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PLK3_HUMAN
NC score	0.063847 (rank : 187)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	124	Target Neighborhood Hits	865	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

GRK7_HUMAN
NC score	0.063604 (rank : 188)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	124	Target Neighborhood Hits	820	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

NOLC1_HUMAN
NC score	0.063456 (rank : 189)	θ value	0.00665767 (rank : 14)
Query Neighborhood Hits	124	Target Neighborhood Hits	452	Shared Neighborhood Hits	22
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

AURKC_HUMAN
NC score	0.063268 (rank : 190)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

ST38L_MOUSE
NC score	0.063218 (rank : 191)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

AURKC_MOUSE
NC score	0.063090 (rank : 192)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	9
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

CLK4_HUMAN
NC score	0.063084 (rank : 193)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	124	Target Neighborhood Hits	759	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

TITIN_HUMAN
NC score	0.063029 (rank : 194)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	124	Target Neighborhood Hits	2923	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ULK1_MOUSE
NC score	0.062947 (rank : 195)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	124	Target Neighborhood Hits	1214	Shared Neighborhood Hits	41
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

SCYL2_HUMAN
NC score	0.062879 (rank : 196)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	124	Target Neighborhood Hits	632	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

CLK1_MOUSE
NC score	0.062875 (rank : 197)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	124	Target Neighborhood Hits	760	Shared Neighborhood Hits	10
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

F5006_MOUSE
NC score	0.062863 (rank : 198)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	124	Target Neighborhood Hits	793	Shared Neighborhood Hits	9
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

ULK2_MOUSE
NC score	0.062839 (rank : 199)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	124	Target Neighborhood Hits	943	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

TSSK4_HUMAN
NC score	0.062812 (rank : 200)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

CLK4_MOUSE
NC score	0.062732 (rank : 201)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	124	Target Neighborhood Hits	759	Shared Neighborhood Hits	9
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

ULK1_HUMAN
NC score	0.062648 (rank : 202)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	124	Target Neighborhood Hits	1121	Shared Neighborhood Hits	25
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK4_MOUSE
NC score	0.062636 (rank : 203)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	124	Target Neighborhood Hits	793	Shared Neighborhood Hits	9
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

PLK3_MOUSE
NC score	0.062496 (rank : 204)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	124	Target Neighborhood Hits	863	Shared Neighborhood Hits	10
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK1_MOUSE
NC score	0.062454 (rank : 205)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

TLK2_HUMAN
NC score	0.062442 (rank : 206)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	124	Target Neighborhood Hits	1044	Shared Neighborhood Hits	12
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

STK38_HUMAN
NC score	0.062394 (rank : 207)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TSSK4_MOUSE
NC score	0.062390 (rank : 208)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

ST32C_MOUSE
NC score	0.062340 (rank : 209)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

NUAK2_MOUSE
NC score	0.062174 (rank : 210)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

TLK2_MOUSE
NC score	0.062136 (rank : 211)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	124	Target Neighborhood Hits	1088	Shared Neighborhood Hits	11
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

STK38_MOUSE
NC score	0.062042 (rank : 212)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

ST38L_HUMAN
NC score	0.061883 (rank : 213)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST32C_HUMAN
NC score	0.061799 (rank : 214)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	124	Target Neighborhood Hits	832	Shared Neighborhood Hits	9
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

DYRK4_HUMAN
NC score	0.061675 (rank : 215)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	124	Target Neighborhood Hits	750	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

OBSCN_HUMAN
NC score	0.061641 (rank : 216)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	124	Target Neighborhood Hits	1931	Shared Neighborhood Hits	36
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PLK1_HUMAN
NC score	0.061501 (rank : 217)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_MOUSE
NC score	0.061260 (rank : 218)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MAST2_MOUSE
NC score	0.061173 (rank : 219)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	124	Target Neighborhood Hits	1110	Shared Neighborhood Hits	29
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PLK2_HUMAN
NC score	0.061167 (rank : 220)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

ST32B_MOUSE
NC score	0.061140 (rank : 221)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

NUAK2_HUMAN
NC score	0.061094 (rank : 222)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

CLK1_HUMAN
NC score	0.060998 (rank : 223)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	124	Target Neighborhood Hits	756	Shared Neighborhood Hits	9
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

ST32B_HUMAN
NC score	0.060982 (rank : 224)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

MYCB2_HUMAN
NC score	0.060842 (rank : 225)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	124	Target Neighborhood Hits	390	Shared Neighborhood Hits	20
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

PAK4_MOUSE
NC score	0.060807 (rank : 226)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	124	Target Neighborhood Hits	1098	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

ST32A_MOUSE
NC score	0.060537 (rank : 227)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

MAST2_HUMAN
NC score	0.060460 (rank : 228)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	124	Target Neighborhood Hits	1189	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KPCL_HUMAN
NC score	0.060379 (rank : 229)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	124	Target Neighborhood Hits	887	Shared Neighborhood Hits	10
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

PAK3_HUMAN
NC score	0.060195 (rank : 230)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	124	Target Neighborhood Hits	887	Shared Neighborhood Hits	12
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PDPK1_HUMAN
NC score	0.060194 (rank : 231)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	9
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

SGK1_MOUSE
NC score	0.060193 (rank : 232)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

PAK3_MOUSE
NC score	0.060186 (rank : 233)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	12
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

SGK2_HUMAN
NC score	0.060119 (rank : 234)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

MAST1_HUMAN
NC score	0.060110 (rank : 235)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	124	Target Neighborhood Hits	1146	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KS6B2_MOUSE
NC score	0.060045 (rank : 236)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	124	Target Neighborhood Hits	871	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

ULK3_HUMAN
NC score	0.060003 (rank : 237)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PDPK1_MOUSE
NC score	0.059828 (rank : 238)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	124	Target Neighborhood Hits	852	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

TBK1_MOUSE
NC score	0.059675 (rank : 239)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	124	Target Neighborhood Hits	893	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TBK1_HUMAN
NC score	0.059594 (rank : 240)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	124	Target Neighborhood Hits	861	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

KPCE_HUMAN
NC score	0.059566 (rank : 241)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	124	Target Neighborhood Hits	906	Shared Neighborhood Hits	12
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

SGK1_HUMAN
NC score	0.059416 (rank : 242)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

PAK2_HUMAN
NC score	0.059412 (rank : 243)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	11
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
NC score	0.059411 (rank : 244)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

ERN1_MOUSE
NC score	0.059408 (rank : 245)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	124	Target Neighborhood Hits	823	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ULK3_MOUSE
NC score	0.059338 (rank : 246)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

KPCL_MOUSE
NC score	0.059323 (rank : 247)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	124	Target Neighborhood Hits	891	Shared Neighborhood Hits	10
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

BUB1B_HUMAN
NC score	0.059265 (rank : 248)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	124	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

PAK1_HUMAN
NC score	0.059188 (rank : 249)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	124	Target Neighborhood Hits	873	Shared Neighborhood Hits	11
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

AKT2_HUMAN
NC score	0.059166 (rank : 250)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	9
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

PAK1_MOUSE
NC score	0.059166 (rank : 251)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	12
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

MK04_MOUSE
NC score	0.059151 (rank : 252)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	124	Target Neighborhood Hits	852	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

KS6B1_MOUSE
NC score	0.059128 (rank : 253)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

MK04_HUMAN
NC score	0.059105 (rank : 254)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	10
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

KS6B1_HUMAN
NC score	0.059104 (rank : 255)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	124	Target Neighborhood Hits	850	Shared Neighborhood Hits	9
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

IKKE_MOUSE
NC score	0.059079 (rank : 256)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KPCE_MOUSE
NC score	0.059074 (rank : 257)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	124	Target Neighborhood Hits	906	Shared Neighborhood Hits	11
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MAST1_MOUSE
NC score	0.059041 (rank : 258)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	124	Target Neighborhood Hits	1123	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

STK40_HUMAN
NC score	0.059016 (rank : 259)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	124	Target Neighborhood Hits	751	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

SGK2_MOUSE
NC score	0.058979 (rank : 260)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

KS6A5_MOUSE
NC score	0.058925 (rank : 261)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

PAK4_HUMAN
NC score	0.058899 (rank : 262)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	124	Target Neighborhood Hits	924	Shared Neighborhood Hits	17
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

AKT2_MOUSE
NC score	0.058898 (rank : 263)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	124	Target Neighborhood Hits	875	Shared Neighborhood Hits	9
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

SCYL2_MOUSE
NC score	0.058892 (rank : 264)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	124	Target Neighborhood Hits	603	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

KGP2_HUMAN
NC score	0.058800 (rank : 265)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	124	Target Neighborhood Hits	1023	Shared Neighborhood Hits	14
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

STK40_MOUSE
NC score	0.058785 (rank : 266)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	124	Target Neighborhood Hits	751	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

KGP2_MOUSE
NC score	0.058760 (rank : 267)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	124	Target Neighborhood Hits	1029	Shared Neighborhood Hits	16
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KS6B2_HUMAN
NC score	0.058661 (rank : 268)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	124	Target Neighborhood Hits	858	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

ST32A_HUMAN
NC score	0.058567 (rank : 269)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

AKT1_MOUSE
NC score	0.058549 (rank : 270)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	124	Target Neighborhood Hits	878	Shared Neighborhood Hits	9
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT1_HUMAN
NC score	0.058541 (rank : 271)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	9
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

BUB1_HUMAN
NC score	0.058381 (rank : 272)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	124	Target Neighborhood Hits	543	Shared Neighborhood Hits	17
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

DYRK3_HUMAN
NC score	0.058351 (rank : 273)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	124	Target Neighborhood Hits	798	Shared Neighborhood Hits	9
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

PAK6_HUMAN
NC score	0.058309 (rank : 274)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	124	Target Neighborhood Hits	915	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

MAST3_HUMAN
NC score	0.058282 (rank : 275)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	124	Target Neighborhood Hits	1128	Shared Neighborhood Hits	22
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MK07_HUMAN
NC score	0.058276 (rank : 276)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	124	Target Neighborhood Hits	1087	Shared Neighborhood Hits	24
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

PAK7_MOUSE
NC score	0.058242 (rank : 277)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	124	Target Neighborhood Hits	875	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

MASTL_MOUSE
NC score	0.058145 (rank : 278)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PAK7_HUMAN
NC score	0.058111 (rank : 279)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	124	Target Neighborhood Hits	875	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

AKT3_HUMAN
NC score	0.058053 (rank : 280)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.058050 (rank : 281)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

SGK3_HUMAN
NC score	0.057913 (rank : 282)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	124	Target Neighborhood Hits	877	Shared Neighborhood Hits	9
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
NC score	0.057711 (rank : 283)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	124	Target Neighborhood Hits	882	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

ERN2_HUMAN
NC score	0.057707 (rank : 284)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	124	Target Neighborhood Hits	844	Shared Neighborhood Hits	9
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

IKKB_MOUSE
NC score	0.057668 (rank : 285)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	124	Target Neighborhood Hits	984	Shared Neighborhood Hits	10
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

GRK5_MOUSE
NC score	0.057580 (rank : 286)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	124	Target Neighborhood Hits	823	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

NEK6_MOUSE
NC score	0.057419 (rank : 287)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

GRK5_HUMAN
NC score	0.057366 (rank : 288)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	124	Target Neighborhood Hits	819	Shared Neighborhood Hits	9
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

TTBK2_HUMAN
NC score	0.057318 (rank : 289)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	124	Target Neighborhood Hits	822	Shared Neighborhood Hits	18
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

NEK6_HUMAN
NC score	0.057256 (rank : 290)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	124	Target Neighborhood Hits	848	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK1_MOUSE
NC score	0.057229 (rank : 291)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	124	Target Neighborhood Hits	1311	Shared Neighborhood Hits	26
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK8_MOUSE
NC score	0.057171 (rank : 292)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	11
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

CDKL1_HUMAN
NC score	0.057101 (rank : 293)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

ERN1_HUMAN
NC score	0.057091 (rank : 294)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

DYRK2_HUMAN
NC score	0.057051 (rank : 295)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	9
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

STK36_HUMAN
NC score	0.056993 (rank : 296)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	124	Target Neighborhood Hits	896	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
NC score	0.056969 (rank : 297)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	124	Target Neighborhood Hits	877	Shared Neighborhood Hits	9
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

RK_MOUSE
NC score	0.056943 (rank : 298)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MASTL_HUMAN
NC score	0.056734 (rank : 299)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	124	Target Neighborhood Hits	894	Shared Neighborhood Hits	9
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

IKKB_HUMAN
NC score	0.056693 (rank : 300)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	124	Target Neighborhood Hits	980	Shared Neighborhood Hits	11
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

NEK8_HUMAN
NC score	0.056619 (rank : 301)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	124	Target Neighborhood Hits	872	Shared Neighborhood Hits	11
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

M3K2_MOUSE
NC score	0.056611 (rank : 302)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MARCS_MOUSE
NC score	0.056393 (rank : 303)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	124	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

IRAK2_HUMAN
NC score	0.056294 (rank : 304)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	124	Target Neighborhood Hits	714	Shared Neighborhood Hits	14
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

TTBK2_MOUSE
NC score	0.056280 (rank : 305)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	124	Target Neighborhood Hits	811	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

MOK_HUMAN
NC score	0.056168 (rank : 306)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	124	Target Neighborhood Hits	807	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

NEK1_HUMAN
NC score	0.056151 (rank : 307)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	124	Target Neighborhood Hits	1129	Shared Neighborhood Hits	15
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

HIPK4_HUMAN
NC score	0.056140 (rank : 308)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

DYR1B_MOUSE
NC score	0.056105 (rank : 309)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	124	Target Neighborhood Hits	799	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

KGP1B_HUMAN
NC score	0.056044 (rank : 310)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	124	Target Neighborhood Hits	921	Shared Neighborhood Hits	11
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

IKKE_HUMAN
NC score	0.056043 (rank : 311)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KGP1B_MOUSE
NC score	0.056042 (rank : 312)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	124	Target Neighborhood Hits	922	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

DYR1B_HUMAN
NC score	0.055942 (rank : 313)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

RK_HUMAN
NC score	0.055927 (rank : 314)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KGP1A_HUMAN
NC score	0.055876 (rank : 315)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	124	Target Neighborhood Hits	901	Shared Neighborhood Hits	9
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

M3K8_HUMAN
NC score	0.055862 (rank : 316)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	124	Target Neighborhood Hits	807	Shared Neighborhood Hits	8
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

WNK4_HUMAN
NC score	0.055840 (rank : 317)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	124	Target Neighborhood Hits	1043	Shared Neighborhood Hits	27
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MK06_MOUSE
NC score	0.055816 (rank : 318)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	124	Target Neighborhood Hits	818	Shared Neighborhood Hits	9
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

PKN3_MOUSE
NC score	0.055766 (rank : 319)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	124	Target Neighborhood Hits	1009	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

CSK21_HUMAN
NC score	0.055738 (rank : 320)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	124	Target Neighborhood Hits	772	Shared Neighborhood Hits	8
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

E2AK3_HUMAN
NC score	0.055568 (rank : 321)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

GRK6_HUMAN
NC score	0.055522 (rank : 322)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	124	Target Neighborhood Hits	823	Shared Neighborhood Hits	9
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

CDKL1_MOUSE
NC score	0.055520 (rank : 323)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

M3K2_HUMAN
NC score	0.055435 (rank : 324)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MK06_HUMAN
NC score	0.055325 (rank : 325)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	124	Target Neighborhood Hits	815	Shared Neighborhood Hits	9
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

GRK6_MOUSE
NC score	0.055235 (rank : 326)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	124	Target Neighborhood Hits	820	Shared Neighborhood Hits	9
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

WNK4_MOUSE
NC score	0.055018 (rank : 327)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	124	Target Neighborhood Hits	961	Shared Neighborhood Hits	21
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MK15_HUMAN
NC score	0.054963 (rank : 328)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	124	Target Neighborhood Hits	1038	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

NEK3_MOUSE
NC score	0.054896 (rank : 329)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
NC score	0.054850 (rank : 330)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	124	Target Neighborhood Hits	883	Shared Neighborhood Hits	9
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

DMPK_HUMAN
NC score	0.054845 (rank : 331)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	124	Target Neighborhood Hits	944	Shared Neighborhood Hits	10
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

CDKL3_MOUSE
NC score	0.054777 (rank : 332)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

MOK_MOUSE
NC score	0.054734 (rank : 333)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	124	Target Neighborhood Hits	796	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

HIPK1_HUMAN
NC score	0.054682 (rank : 334)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	13
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

M3K8_MOUSE
NC score	0.054669 (rank : 335)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	124	Target Neighborhood Hits	815	Shared Neighborhood Hits	8
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

WNK2_HUMAN
NC score	0.054652 (rank : 336)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	124	Target Neighborhood Hits	1407	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

NEK4_MOUSE
NC score	0.054642 (rank : 337)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

TTBK1_HUMAN
NC score	0.054629 (rank : 338)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	124	Target Neighborhood Hits	1058	Shared Neighborhood Hits	25
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

DMPK_MOUSE
NC score	0.054615 (rank : 339)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	124	Target Neighborhood Hits	908	Shared Neighborhood Hits	10
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

GRK4_HUMAN
NC score	0.054569 (rank : 340)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	124	Target Neighborhood Hits	822	Shared Neighborhood Hits	9
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

KPCI_MOUSE
NC score	0.054547 (rank : 341)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	9
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCI_HUMAN
NC score	0.054538 (rank : 342)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	9
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

NEK7_HUMAN
NC score	0.054518 (rank : 343)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	124	Target Neighborhood Hits	846	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

HIPK1_MOUSE
NC score	0.054511 (rank : 344)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	13
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

ARBK2_HUMAN
NC score	0.054475 (rank : 345)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

CSK21_MOUSE
NC score	0.054455 (rank : 346)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	124	Target Neighborhood Hits	770	Shared Neighborhood Hits	8
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

MK13_MOUSE
NC score	0.054347 (rank : 347)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	124	Target Neighborhood Hits	832	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK09_HUMAN
NC score	0.054328 (rank : 348)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	124	Target Neighborhood Hits	842	Shared Neighborhood Hits	9
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK12_HUMAN
NC score	0.054326 (rank : 349)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	124	Target Neighborhood Hits	830	Shared Neighborhood Hits	9
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK07_MOUSE
NC score	0.054322 (rank : 350)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	124	Target Neighborhood Hits	1054	Shared Neighborhood Hits	17
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

CDKL3_HUMAN
NC score	0.054246 (rank : 351)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	124	Target Neighborhood Hits	853	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

KPCZ_MOUSE
NC score	0.054220 (rank : 352)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	124	Target Neighborhood Hits	882	Shared Neighborhood Hits	9
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.054174 (rank : 353)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	9
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

NEK3_HUMAN
NC score	0.054155 (rank : 354)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	124	Target Neighborhood Hits	865	Shared Neighborhood Hits	9
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

STK16_MOUSE
NC score	0.054096 (rank : 355)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

CSK22_HUMAN
NC score	0.054086 (rank : 356)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	124	Target Neighborhood Hits	758	Shared Neighborhood Hits	9
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CDKL2_MOUSE
NC score	0.054054 (rank : 357)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	124	Target Neighborhood Hits	854	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

HIPK3_MOUSE
NC score	0.054016 (rank : 358)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

M3K6_HUMAN
NC score	0.053988 (rank : 359)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	124	Target Neighborhood Hits	889	Shared Neighborhood Hits	11
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

CDKL4_MOUSE
NC score	0.053976 (rank : 360)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	124	Target Neighborhood Hits	833	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CSK22_MOUSE
NC score	0.053938 (rank : 361)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	124	Target Neighborhood Hits	758	Shared Neighborhood Hits	9
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

HIPK2_MOUSE
NC score	0.053876 (rank : 362)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	124	Target Neighborhood Hits	871	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

GRK4_MOUSE
NC score	0.053715 (rank : 363)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	124	Target Neighborhood Hits	808	Shared Neighborhood Hits	9
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

AL2S7_HUMAN
NC score	0.053699 (rank : 364)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	124	Target Neighborhood Hits	831	Shared Neighborhood Hits	9
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ARBK1_HUMAN
NC score	0.053631 (rank : 365)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	124	Target Neighborhood Hits	859	Shared Neighborhood Hits	9
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

MK14_MOUSE
NC score	0.053623 (rank : 366)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK13_HUMAN
NC score	0.053618 (rank : 367)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

NEK7_MOUSE
NC score	0.053610 (rank : 368)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	124	Target Neighborhood Hits	847	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MK14_HUMAN
NC score	0.053529 (rank : 369)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

HIPK2_HUMAN
NC score	0.053482 (rank : 370)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	124	Target Neighborhood Hits	845	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

MK03_MOUSE
NC score	0.053473 (rank : 371)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

HIPK3_HUMAN
NC score	0.053459 (rank : 372)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

SRRM2_MOUSE
NC score	0.053410 (rank : 373)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	124	Target Neighborhood Hits	1470	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

KPCG_MOUSE
NC score	0.053344 (rank : 374)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	124	Target Neighborhood Hits	1123	Shared Neighborhood Hits	14
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PKN3_HUMAN
NC score	0.053339 (rank : 375)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	124	Target Neighborhood Hits	893	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

WNK1_MOUSE
NC score	0.053331 (rank : 376)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	124	Target Neighborhood Hits	1179	Shared Neighborhood Hits	26
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

PFTK1_MOUSE
NC score	0.053310 (rank : 377)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KPCG_HUMAN
NC score	0.053261 (rank : 378)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	124	Target Neighborhood Hits	1126	Shared Neighborhood Hits	14
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

CDKL2_HUMAN
NC score	0.053238 (rank : 379)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	124	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

ARBK1_MOUSE
NC score	0.053178 (rank : 380)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	124	Target Neighborhood Hits	849	Shared Neighborhood Hits	9
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

WNK1_HUMAN
NC score	0.053167 (rank : 381)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	124	Target Neighborhood Hits	1158	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

CDC7_MOUSE
NC score	0.053112 (rank : 382)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	124	Target Neighborhood Hits	641	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

PFTK1_HUMAN
NC score	0.053105 (rank : 383)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

LATS2_MOUSE
NC score	0.053092 (rank : 384)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	124	Target Neighborhood Hits	879	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

DYR1A_HUMAN
NC score	0.053041 (rank : 385)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	124	Target Neighborhood Hits	764	Shared Neighborhood Hits	8
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
NC score	0.053033 (rank : 386)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	124	Target Neighborhood Hits	762	Shared Neighborhood Hits	8
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

MK03_HUMAN
NC score	0.053011 (rank : 387)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

BUB1_MOUSE
NC score	0.052992 (rank : 388)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	124	Target Neighborhood Hits	583	Shared Neighborhood Hits	8
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

MK01_MOUSE
NC score	0.052987 (rank : 389)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_HUMAN
NC score	0.052971 (rank : 390)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	124	Target Neighborhood Hits	836	Shared Neighborhood Hits	9
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK08_MOUSE
NC score	0.052859 (rank : 391)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK08_HUMAN
NC score	0.052814 (rank : 392)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	124	Target Neighborhood Hits	834	Shared Neighborhood Hits	9
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

PKN2_MOUSE
NC score	0.052748 (rank : 393)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	124	Target Neighborhood Hits	899	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

CDK6_HUMAN
NC score	0.052739 (rank : 394)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

M3K3_HUMAN
NC score	0.052663 (rank : 395)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	12
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

KPCA_HUMAN
NC score	0.052558 (rank : 396)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	124	Target Neighborhood Hits	1070	Shared Neighborhood Hits	12
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

E2AK3_MOUSE
NC score	0.052546 (rank : 397)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	124	Target Neighborhood Hits	851	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

KPCD_MOUSE
NC score	0.052536 (rank : 398)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	9
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

OXSR1_HUMAN
NC score	0.052529 (rank : 399)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	124	Target Neighborhood Hits	874	Shared Neighborhood Hits	11
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

M3K3_MOUSE
NC score	0.052491 (rank : 400)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	124	Target Neighborhood Hits	876	Shared Neighborhood Hits	11
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

PKN1_MOUSE
NC score	0.052484 (rank : 401)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	124	Target Neighborhood Hits	888	Shared Neighborhood Hits	9
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

MK09_MOUSE
NC score	0.052370 (rank : 402)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

CDKL4_HUMAN
NC score	0.052256 (rank : 403)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDK6_MOUSE
NC score	0.052244 (rank : 404)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	124	Target Neighborhood Hits	837	Shared Neighborhood Hits	9
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

PKN2_HUMAN
NC score	0.052235 (rank : 405)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	124	Target Neighborhood Hits	892	Shared Neighborhood Hits	9
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

TTK_HUMAN
NC score	0.052164 (rank : 406)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	124	Target Neighborhood Hits	816	Shared Neighborhood Hits	10
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

OXSR1_MOUSE
NC score	0.052101 (rank : 407)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	124	Target Neighborhood Hits	865	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

MK12_MOUSE
NC score	0.052099 (rank : 408)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

KPCB_MOUSE
NC score	0.052098 (rank : 409)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	124	Target Neighborhood Hits	1117	Shared Neighborhood Hits	12
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

E2AK1_MOUSE
NC score	0.051991 (rank : 410)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	124	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MRCKA_HUMAN
NC score	0.051940 (rank : 411)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	124	Target Neighborhood Hits	1999	Shared Neighborhood Hits	29
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

KPCB_HUMAN
NC score	0.051897 (rank : 412)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	124	Target Neighborhood Hits	1121	Shared Neighborhood Hits	12
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PKN1_HUMAN
NC score	0.051888 (rank : 413)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	124	Target Neighborhood Hits	886	Shared Neighborhood Hits	11
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

IKKA_MOUSE
NC score	0.051829 (rank : 414)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	124	Target Neighborhood Hits	867	Shared Neighborhood Hits	9
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

TESK1_HUMAN
NC score	0.051711 (rank : 415)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	124	Target Neighborhood Hits	864	Shared Neighborhood Hits	12
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

KPCA_MOUSE
NC score	0.051698 (rank : 416)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	124	Target Neighborhood Hits	1067	Shared Neighborhood Hits	12
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PINK1_HUMAN
NC score	0.051666 (rank : 417)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	124	Target Neighborhood Hits	741	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

WNK3_HUMAN
NC score	0.051603 (rank : 418)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	124	Target Neighborhood Hits	948	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

CTRO_MOUSE
NC score	0.051569 (rank : 419)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	124	Target Neighborhood Hits	2344	Shared Neighborhood Hits	34
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

TESK1_MOUSE
NC score	0.051525 (rank : 420)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	124	Target Neighborhood Hits	862	Shared Neighborhood Hits	10
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

IKKA_HUMAN
NC score	0.051482 (rank : 421)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	124	Target Neighborhood Hits	863	Shared Neighborhood Hits	9
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

ERN2_MOUSE
NC score	0.051468 (rank : 422)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	124	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

STK39_MOUSE
NC score	0.051387 (rank : 423)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	124	Target Neighborhood Hits	915	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

CTRO_HUMAN
NC score	0.051355 (rank : 424)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	124	Target Neighborhood Hits	2092	Shared Neighborhood Hits	27
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

E2AK2_HUMAN
NC score	0.051311 (rank : 425)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	124	Target Neighborhood Hits	856	Shared Neighborhood Hits	9
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

CDKL5_HUMAN
NC score	0.051305 (rank : 426)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	124	Target Neighborhood Hits	967	Shared Neighborhood Hits	22
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

TTK_MOUSE
NC score	0.051283 (rank : 427)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	124	Target Neighborhood Hits	803	Shared Neighborhood Hits	11
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

STK39_HUMAN
NC score	0.051277 (rank : 428)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	124	Target Neighborhood Hits	882	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

LATS1_MOUSE
NC score	0.051222 (rank : 429)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	124	Target Neighborhood Hits	1027	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

CDK3_MOUSE
NC score	0.051217 (rank : 430)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	124	Target Neighborhood Hits	829	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

MAK_MOUSE
NC score	0.051180 (rank : 431)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	124	Target Neighborhood Hits	873	Shared Neighborhood Hits	11
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

KPCT_HUMAN
NC score	0.051146 (rank : 432)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	124	Target Neighborhood Hits	897	Shared Neighborhood Hits	9
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KC1A_HUMAN
NC score	0.051133 (rank : 433)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	124	Target Neighborhood Hits	728	Shared Neighborhood Hits	8
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.051133 (rank : 434)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	124	Target Neighborhood Hits	728	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

STK16_HUMAN
NC score	0.051123 (rank : 435)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	124	Target Neighborhood Hits	824	Shared Neighborhood Hits	9
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

MKL2_HUMAN
NC score	0.051059 (rank : 436)	θ value	0.0431538 (rank : 16)
Query Neighborhood Hits	124	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

ARAF_HUMAN
NC score	0.050885 (rank : 437)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	124	Target Neighborhood Hits	924	Shared Neighborhood Hits	16
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

NLK_HUMAN
NC score	0.050859 (rank : 438)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	124	Target Neighborhood Hits	840	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
NC score	0.050858 (rank : 439)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	124	Target Neighborhood Hits	839	Shared Neighborhood Hits	9
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

LATS1_HUMAN
NC score	0.050822 (rank : 440)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	124	Target Neighborhood Hits	1057	Shared Neighborhood Hits	17
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

IRAK3_HUMAN
NC score	0.050780 (rank : 441)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	124	Target Neighborhood Hits	644	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

GSK3B_HUMAN
NC score	0.050764 (rank : 442)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	124	Target Neighborhood Hits	801	Shared Neighborhood Hits	9
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.050763 (rank : 443)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	124	Target Neighborhood Hits	800	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3A_HUMAN
NC score	0.050599 (rank : 444)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	11
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

SRRM1_MOUSE
NC score	0.050590 (rank : 445)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	124	Target Neighborhood Hits	966	Shared Neighborhood Hits	50
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

M3K4_HUMAN
NC score	0.050576 (rank : 446)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	124	Target Neighborhood Hits	911	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
NC score	0.050553 (rank : 447)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	124	Target Neighborhood Hits	924	Shared Neighborhood Hits	15
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

YSK4_HUMAN
NC score	0.050494 (rank : 448)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	124	Target Neighborhood Hits	921	Shared Neighborhood Hits	10
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

MAK_HUMAN
NC score	0.050489 (rank : 449)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	124	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MK11_MOUSE
NC score	0.050443 (rank : 450)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	124	Target Neighborhood Hits	835	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

STK4_HUMAN
NC score	0.050424 (rank : 451)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	124	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

MK15_MOUSE
NC score	0.050385 (rank : 452)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	124	Target Neighborhood Hits	843	Shared Neighborhood Hits	10
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

KPCT_MOUSE
NC score	0.050385 (rank : 453)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	124	Target Neighborhood Hits	895	Shared Neighborhood Hits	9
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

ROCK2_HUMAN
NC score	0.050311 (rank : 454)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	124	Target Neighborhood Hits	2073	Shared Neighborhood Hits	24
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

M3K7_MOUSE
NC score	0.050193 (rank : 455)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	124	Target Neighborhood Hits	892	Shared Neighborhood Hits	9
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.050115 (rank : 456)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	124	Target Neighborhood Hits	892	Shared Neighborhood Hits	9
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

STK4_MOUSE
NC score	0.050108 (rank : 457)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	124	Target Neighborhood Hits	873	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

LATS2_HUMAN
NC score	0.050087 (rank : 458)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	124	Target Neighborhood Hits	884	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

MST4_MOUSE
NC score	0.050024 (rank : 459)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	124	Target Neighborhood Hits	860	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

BSN_MOUSE
NC score	0.048359 (rank : 460)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	124	Target Neighborhood Hits	2057	Shared Neighborhood Hits	78
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CNOT3_MOUSE
NC score	0.048145 (rank : 461)	θ value	0.21417 (rank : 23)
Query Neighborhood Hits	124	Target Neighborhood Hits	504	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

IF35_HUMAN
NC score	0.047035 (rank : 462)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	124	Target Neighborhood Hits	130	Shared Neighborhood Hits	10
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

NU214_HUMAN
NC score	0.046873 (rank : 463)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	124	Target Neighborhood Hits	657	Shared Neighborhood Hits	33
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

BSN_HUMAN
NC score	0.046401 (rank : 464)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	124	Target Neighborhood Hits	1537	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

SRRM1_HUMAN
NC score	0.044944 (rank : 465)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	124	Target Neighborhood Hits	690	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

MUC7_HUMAN
NC score	0.043514 (rank : 466)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	124	Target Neighborhood Hits	538	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SRRM2_HUMAN
NC score	0.043022 (rank : 467)	θ value	1.38821 (rank : 47)
Query Neighborhood Hits	124	Target Neighborhood Hits	1296	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

HRX_HUMAN
NC score	0.042730 (rank : 468)	θ value	0.0736092 (rank : 17)
Query Neighborhood Hits	124	Target Neighborhood Hits	825	Shared Neighborhood Hits	32
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

BASP_HUMAN
NC score	0.039400 (rank : 469)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	124	Target Neighborhood Hits	321	Shared Neighborhood Hits	23
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

SFR16_MOUSE
NC score	0.037817 (rank : 470)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

CN004_MOUSE
NC score	0.037753 (rank : 471)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

PDXL2_MOUSE
NC score	0.036900 (rank : 472)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	124	Target Neighborhood Hits	213	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

CN004_HUMAN
NC score	0.036263 (rank : 473)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	124	Target Neighborhood Hits	108	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

SET1A_HUMAN
NC score	0.036121 (rank : 474)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	124	Target Neighborhood Hits	690	Shared Neighborhood Hits	33
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

NFAC3_MOUSE
NC score	0.036024 (rank : 475)	θ value	0.47712 (rank : 30)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	P97305, Q60896	Gene names	Nfatc3, Nfat4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

MUC1_HUMAN
NC score	0.035746 (rank : 476)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	124	Target Neighborhood Hits	975	Shared Neighborhood Hits	58
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

ZAR1_MOUSE
NC score	0.035587 (rank : 477)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	124	Target Neighborhood Hits	254	Shared Neighborhood Hits	24
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

RBM5_MOUSE
NC score	0.035517 (rank : 478)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	124	Target Neighborhood Hits	216	Shared Neighborhood Hits	7
SwissProt Accessions	Q91YE7, Q3UZ19, Q99KV9	Gene names	Rbm5, Luca15
Domain Architecture	No domain graphic available
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15).

NFAC3_HUMAN
NC score	0.035300 (rank : 479)	θ value	0.365318 (rank : 27)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

DBP_HUMAN
NC score	0.035281 (rank : 480)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	124	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	Q10586	Gene names	DBP
Domain Architecture
Description	D site-binding protein (Albumin D box-binding protein) (Albumin D- element-binding protein) (TAXREB302).

SYN3_MOUSE
NC score	0.035067 (rank : 481)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	124	Target Neighborhood Hits	200	Shared Neighborhood Hits	20
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

XRCC1_MOUSE
NC score	0.032917 (rank : 482)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	124	Target Neighborhood Hits	242	Shared Neighborhood Hits	11
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

INSRR_HUMAN
NC score	0.032504 (rank : 483)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	124	Target Neighborhood Hits	950	Shared Neighborhood Hits	13
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PCLO_MOUSE
NC score	0.032106 (rank : 484)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	124	Target Neighborhood Hits	2275	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

K1802_MOUSE
NC score	0.031948 (rank : 485)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	124	Target Neighborhood Hits	1596	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

CS016_HUMAN
NC score	0.031919 (rank : 486)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	124	Target Neighborhood Hits	310	Shared Neighborhood Hits	19
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

RBM5_HUMAN
NC score	0.031100 (rank : 487)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	124	Target Neighborhood Hits	216	Shared Neighborhood Hits	6
SwissProt Accessions	P52756, Q93021, Q9BU14, Q9UKY8, Q9UL24	Gene names	RBM5
Domain Architecture
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15) (Protein G15) (NY-REN-9 antigen).

BTBDC_HUMAN
NC score	0.030988 (rank : 488)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	124	Target Neighborhood Hits	248	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

RPB1_MOUSE
NC score	0.030256 (rank : 489)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	124	Target Neighborhood Hits	363	Shared Neighborhood Hits	18
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RFA1_MOUSE
NC score	0.030014 (rank : 490)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	124	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VEE4, Q3TEJ8	Gene names	Rpa1
Domain Architecture	No domain graphic available
Description	Replication protein A 70 kDa DNA-binding subunit (RP-A) (RF-A) (Replication factor-A protein 1) (p70).

MDN1_HUMAN
NC score	0.029610 (rank : 491)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	124	Target Neighborhood Hits	662	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

MINT_MOUSE
NC score	0.028432 (rank : 492)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	124	Target Neighborhood Hits	1514	Shared Neighborhood Hits	56
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

RPB1_HUMAN
NC score	0.028305 (rank : 493)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	124	Target Neighborhood Hits	362	Shared Neighborhood Hits	17
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SYN1_HUMAN
NC score	0.027772 (rank : 494)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	124	Target Neighborhood Hits	419	Shared Neighborhood Hits	25
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

K1802_HUMAN
NC score	0.027675 (rank : 495)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	124	Target Neighborhood Hits	1378	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SYN3_HUMAN
NC score	0.027637 (rank : 496)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	124	Target Neighborhood Hits	203	Shared Neighborhood Hits	15
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

SYN2_MOUSE
NC score	0.027449 (rank : 497)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	124	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	Q64332, Q6NZR0, Q9QWV7	Gene names	Syn2
Domain Architecture	No domain graphic available
Description	Synapsin-2 (Synapsin II).

ATRX_MOUSE
NC score	0.027034 (rank : 498)	θ value	0.47712 (rank : 29)
Query Neighborhood Hits	124	Target Neighborhood Hits	682	Shared Neighborhood Hits	25
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

DYNA_MOUSE
NC score	0.026920 (rank : 499)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	124	Target Neighborhood Hits	1084	Shared Neighborhood Hits	16
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

YTDC1_HUMAN
NC score	0.026745 (rank : 500)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	124	Target Neighborhood Hits	458	Shared Neighborhood Hits	18
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

DYNA_HUMAN
NC score	0.025966 (rank : 501)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	124	Target Neighborhood Hits	1194	Shared Neighborhood Hits	18
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

PHLB1_HUMAN
NC score	0.025295 (rank : 502)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	124	Target Neighborhood Hits	1038	Shared Neighborhood Hits	38
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

TAF6_MOUSE
NC score	0.025014 (rank : 503)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	124	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

AFF1_HUMAN
NC score	0.024573 (rank : 504)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	124	Target Neighborhood Hits	506	Shared Neighborhood Hits	29
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

3BP1_HUMAN
NC score	0.023560 (rank : 505)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	124	Target Neighborhood Hits	376	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

BAG3_HUMAN
NC score	0.022994 (rank : 506)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	124	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

TF3C1_HUMAN
NC score	0.022948 (rank : 507)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	124	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

PHLB1_MOUSE
NC score	0.021515 (rank : 508)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	124	Target Neighborhood Hits	678	Shared Neighborhood Hits	24
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PCQAP_MOUSE
NC score	0.021445 (rank : 509)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	124	Target Neighborhood Hits	506	Shared Neighborhood Hits	18
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PCQAP_HUMAN
NC score	0.021129 (rank : 510)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	124	Target Neighborhood Hits	549	Shared Neighborhood Hits	23
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

UBQL2_HUMAN
NC score	0.020149 (rank : 511)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	124	Target Neighborhood Hits	103	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD9, O94798, Q9H3W6, Q9HAZ4	Gene names	UBQLN2, PLIC2
Domain Architecture
Description	Ubiquilin-2 (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC- 2) (Ubiquitin-like product Chap1/Dsk2) (DSK2 homolog) (Chap1).

RFIP5_MOUSE
NC score	0.019370 (rank : 512)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

MUC2_HUMAN
NC score	0.019312 (rank : 513)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	124	Target Neighborhood Hits	906	Shared Neighborhood Hits	26
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

RD23A_HUMAN
NC score	0.019070 (rank : 514)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	124	Target Neighborhood Hits	73	Shared Neighborhood Hits	6
SwissProt Accessions	P54725	Gene names	RAD23A
Domain Architecture
Description	UV excision repair protein RAD23 homolog A (hHR23A).

CABP4_MOUSE
NC score	0.018782 (rank : 515)	θ value	0.0961366 (rank : 19)
Query Neighborhood Hits	124	Target Neighborhood Hits	212	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHC5	Gene names	Cabp4
Domain Architecture	No domain graphic available
Description	Calcium-binding protein 4 (CaBP4).

SYNJ1_MOUSE
NC score	0.016801 (rank : 516)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	124	Target Neighborhood Hits	516	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

ZC3H3_MOUSE
NC score	0.016561 (rank : 517)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	124	Target Neighborhood Hits	188	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

SOX18_HUMAN
NC score	0.016108 (rank : 518)	θ value	0.47712 (rank : 31)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	P35713, Q9NPH8	Gene names	SOX18
Domain Architecture
Description	Transcription factor SOX-18.

5NT1B_HUMAN
NC score	0.015250 (rank : 519)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	124	Target Neighborhood Hits	83	Shared Neighborhood Hits	10
SwissProt Accessions	Q96P26, Q8N9W3, Q8NA26, Q96DU5, Q96KE6, Q96M25, Q96SA3	Gene names	NT5C1B, AIRP
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

GA2L3_HUMAN
NC score	0.015028 (rank : 520)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	124	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XJ1	Gene names	GAS2L3
Domain Architecture	No domain graphic available
Description	GAS2-like protein 3 (Growth arrest-specific 2-like 3).

RTBDN_HUMAN
NC score	0.014733 (rank : 521)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	124	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BSG5, Q9BWT5	Gene names	RTBDN
Domain Architecture	No domain graphic available
Description	Retbindin precursor.

AAKG2_MOUSE
NC score	0.013982 (rank : 522)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	124	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q91WG5, Q6V7V5	Gene names	Prkag2
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma-2 chain) (AMPK gamma2).

MADCA_HUMAN
NC score	0.013974 (rank : 523)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	124	Target Neighborhood Hits	221	Shared Neighborhood Hits	14
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

CUTL1_HUMAN
NC score	0.013853 (rank : 524)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	124	Target Neighborhood Hits	1574	Shared Neighborhood Hits	35
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

PCDGG_HUMAN
NC score	0.013377 (rank : 525)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	124	Target Neighborhood Hits	163	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN71, O15099, Q9UN64	Gene names	PCDHGB4, CDH20, FIB2
Domain Architecture
Description	Protocadherin gamma B4 precursor (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin 2).

CAC1G_HUMAN
NC score	0.013316 (rank : 526)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	124	Target Neighborhood Hits	587	Shared Neighborhood Hits	40
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

NFH_HUMAN
NC score	0.013306 (rank : 527)	θ value	0.365318 (rank : 28)
Query Neighborhood Hits	124	Target Neighborhood Hits	1242	Shared Neighborhood Hits	31
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SYTL2_MOUSE
NC score	0.012752 (rank : 528)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	124	Target Neighborhood Hits	253	Shared Neighborhood Hits	14
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CBX6_HUMAN
NC score	0.012004 (rank : 529)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	9
SwissProt Accessions	O95503, Q96EM5	Gene names	CBX6
Domain Architecture
Description	Chromobox protein homolog 6.

VEGFB_HUMAN
NC score	0.011476 (rank : 530)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	124	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	P49765, Q16528	Gene names	VEGFB, VRF
Domain Architecture
Description	Vascular endothelial growth factor B precursor (VEGF-B) (VEGF-related factor) (VRF).

SREC2_HUMAN
NC score	0.011279 (rank : 531)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	124	Target Neighborhood Hits	645	Shared Neighborhood Hits	17
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SFR12_MOUSE
NC score	0.010882 (rank : 532)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	124	Target Neighborhood Hits	486	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

PCDGH_HUMAN
NC score	0.010795 (rank : 533)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	124	Target Neighborhood Hits	164	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y5G0, Q9Y5C6	Gene names	PCDHGB5
Domain Architecture
Description	Protocadherin gamma B5 precursor (PCDH-gamma-B5).

3BP1_MOUSE
NC score	0.010404 (rank : 534)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	124	Target Neighborhood Hits	238	Shared Neighborhood Hits	13
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MSH6_HUMAN
NC score	0.010211 (rank : 535)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	124	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	P52701, O43706, O43917, Q8TCX4, Q9BTB5	Gene names	MSH6, GTBP
Domain Architecture
Description	DNA mismatch repair protein MSH6 (MutS-alpha 160 kDa subunit) (G/T mismatch-binding protein) (GTBP) (GTMBP) (p160).

MMP9_MOUSE
NC score	0.009896 (rank : 536)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	124	Target Neighborhood Hits	151	Shared Neighborhood Hits	9
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

HDAC2_HUMAN
NC score	0.008419 (rank : 537)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	124	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q92769, Q5SRI8, Q5SZ86, Q8NEH4	Gene names	HDAC2
Domain Architecture
Description	Histone deacetylase 2 (HD2).

PRDM2_HUMAN
NC score	0.008358 (rank : 538)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	124	Target Neighborhood Hits	1135	Shared Neighborhood Hits	26
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

PAPOA_HUMAN
NC score	0.008251 (rank : 539)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	124	Target Neighborhood Hits	75	Shared Neighborhood Hits	6
SwissProt Accessions	P51003, Q86SX4, Q86TV0, Q8IYF5, Q9BVU2	Gene names	PAPOLA, PAP
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase alpha (EC 2.7.7.19) (PAP) (Polynucleotide adenylyltransferase alpha).

LIPB2_MOUSE
NC score	0.008078 (rank : 540)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	124	Target Neighborhood Hits	570	Shared Neighborhood Hits	15
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

PCDGJ_HUMAN
NC score	0.007442 (rank : 541)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	124	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y5F8, Q9UN63	Gene names	PCDHGB7
Domain Architecture
Description	Protocadherin gamma B7 precursor (PCDH-gamma-B7).

CO5A2_HUMAN
NC score	0.007439 (rank : 542)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	124	Target Neighborhood Hits	760	Shared Neighborhood Hits	19
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

ZBTB4_HUMAN
NC score	0.007179 (rank : 543)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	124	Target Neighborhood Hits	926	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

DUS8_HUMAN
NC score	0.006965 (rank : 544)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	124	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

LMX1A_HUMAN
NC score	0.006954 (rank : 545)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	124	Target Neighborhood Hits	406	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE12, Q8TE11	Gene names	LMX1A
Domain Architecture
Description	LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM-homeobox protein 1.1) (LMX-1.1).

UBP31_HUMAN
NC score	0.006883 (rank : 546)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	124	Target Neighborhood Hits	293	Shared Neighborhood Hits	17
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

DOC2B_MOUSE
NC score	0.006288 (rank : 547)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	124	Target Neighborhood Hits	169	Shared Neighborhood Hits	4
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

ES8L3_HUMAN
NC score	0.006263 (rank : 548)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	124	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HXB5_HUMAN
NC score	0.006200 (rank : 549)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	124	Target Neighborhood Hits	332	Shared Neighborhood Hits	6
SwissProt Accessions	P09067, P09069	Gene names	HOXB5, HOX2A
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2A) (HHO.C10) (HU-1).

BCL3_MOUSE
NC score	0.005787 (rank : 550)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	124	Target Neighborhood Hits	388	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

WWP2_HUMAN
NC score	0.004954 (rank : 551)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

HXB5_MOUSE
NC score	0.004793 (rank : 552)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	124	Target Neighborhood Hits	337	Shared Neighborhood Hits	7
SwissProt Accessions	P09079, Q3ZAY8	Gene names	Hoxb5, Hox-2.1, Hoxb-5
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2.1) (MU-1) (H24.1).

B3A2_HUMAN
NC score	0.003860 (rank : 553)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	124	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

ATS4_HUMAN
NC score	0.002286 (rank : 554)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	124	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ZN592_MOUSE
NC score	0.001705 (rank : 555)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	124	Target Neighborhood Hits	768	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BHZ4, Q80XM1	Gene names	Znf592, Kiaa0211, Zfp592
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592 (Zfp-592).

ZN592_HUMAN
NC score	0.001561 (rank : 556)	θ value	6.88961 (rank : 107)
Query Neighborhood Hits	124	Target Neighborhood Hits	762	Shared Neighborhood Hits	10
SwissProt Accessions	Q92610	Gene names	ZNF592, KIAA0211
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592.