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Network neighborhood for query Sequence : WWP2_HUMAN

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WWP2_HUMAN
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITCH_HUMAN
θ value	0 (rank : 1)	NC score	0.981269 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	162	Shared Neighborhood Hits	77
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	0 (rank : 2)	NC score	0.988890 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	127	Shared Neighborhood Hits	75
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	0 (rank : 3)	NC score	0.982917 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	262	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	0 (rank : 4)	NC score	0.989701 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	138	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	0 (rank : 6)	NC score	0.994554 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	92
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NEDD4_HUMAN
θ value	2.19465e-147 (rank : 7)	NC score	0.910956 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	76
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_HUMAN
θ value	1.7995e-141 (rank : 8)	NC score	0.895218 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	238	Shared Neighborhood Hits	81
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	4.00889e-141 (rank : 9)	NC score	0.896247 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	231	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SMUF2_HUMAN
θ value	1.09172e-138 (rank : 10)	NC score	0.960257 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

NEDD4_MOUSE
θ value	2.689e-137 (rank : 11)	NC score	0.914429 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	212	Shared Neighborhood Hits	77
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF1_HUMAN
θ value	2.69525e-129 (rank : 12)	NC score	0.949381 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	1.38424e-125 (rank : 13)	NC score	0.952464 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

HUWE1_HUMAN
θ value	1.14559e-87 (rank : 14)	NC score	0.867338 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	443	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	1.14559e-87 (rank : 15)	NC score	0.868745 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	406	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

UBE3A_HUMAN
θ value	5.73848e-55 (rank : 16)	NC score	0.877651 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

HECD2_MOUSE
θ value	4.85792e-54 (rank : 17)	NC score	0.883743 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
θ value	3.48141e-52 (rank : 18)	NC score	0.880868 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_MOUSE
θ value	6.56568e-51 (rank : 19)	NC score	0.871250 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

K0317_HUMAN
θ value	1.46268e-50 (rank : 20)	NC score	0.877348 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	7.25919e-50 (rank : 21)	NC score	0.876735 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3C_HUMAN
θ value	1.19932e-44 (rank : 22)	NC score	0.859351 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	1.73182e-43 (rank : 23)	NC score	0.857764 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HERC3_HUMAN
θ value	8.59492e-43 (rank : 24)	NC score	0.726219 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

TRIPC_HUMAN
θ value	2.50655e-34 (rank : 25)	NC score	0.800429 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	319	Shared Neighborhood Hits	57
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
θ value	4.00176e-32 (rank : 26)	NC score	0.729475 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC2_MOUSE
θ value	6.38894e-30 (rank : 27)	NC score	0.618082 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	40
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
θ value	2.42779e-29 (rank : 28)	NC score	0.613846 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
θ value	6.18819e-25 (rank : 29)	NC score	0.564506 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	371	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD3_MOUSE
θ value	2.7842e-17 (rank : 30)	NC score	0.695291 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
θ value	1.80466e-16 (rank : 31)	NC score	0.689948 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_HUMAN
θ value	2.20605e-14 (rank : 32)	NC score	0.651108 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	2.20605e-14 (rank : 33)	NC score	0.652745 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

WWC1_HUMAN
θ value	8.38298e-14 (rank : 34)	NC score	0.448407 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	8.38298e-14 (rank : 35)	NC score	0.447398 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

YAP1_MOUSE
θ value	1.86753e-13 (rank : 36)	NC score	0.556640 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	56
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

MAGI1_HUMAN
θ value	4.16044e-13 (rank : 37)	NC score	0.311045 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	388	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

WWOX_HUMAN
θ value	4.16044e-13 (rank : 38)	NC score	0.398353 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	4.16044e-13 (rank : 39)	NC score	0.394927 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

MAGI1_MOUSE
θ value	7.09661e-13 (rank : 40)	NC score	0.311034 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	403	Shared Neighborhood Hits	68
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_MOUSE
θ value	9.26847e-13 (rank : 41)	NC score	0.329602 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	370	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

SAV1_HUMAN
θ value	5.08577e-11 (rank : 42)	NC score	0.531324 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	5.08577e-11 (rank : 43)	NC score	0.530832 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

MAGI2_HUMAN
θ value	1.9326e-10 (rank : 44)	NC score	0.315267 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	373	Shared Neighborhood Hits	51
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

PKHA5_HUMAN
θ value	3.08544e-08 (rank : 45)	NC score	0.284385 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRP40_MOUSE
θ value	1.43324e-05 (rank : 46)	NC score	0.219016 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

BAG3_HUMAN
θ value	2.44474e-05 (rank : 47)	NC score	0.356333 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	57
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	2.44474e-05 (rank : 48)	NC score	0.312192 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	513	Shared Neighborhood Hits	73
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PINL_HUMAN
θ value	3.19293e-05 (rank : 49)	NC score	0.450527 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	44
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWTR1_HUMAN
θ value	3.19293e-05 (rank : 50)	NC score	0.380441 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	3.19293e-05 (rank : 51)	NC score	0.382767 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

PRP40_HUMAN
θ value	4.1701e-05 (rank : 52)	NC score	0.219659 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	442	Shared Neighborhood Hits	49
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PIN1_HUMAN
θ value	5.44631e-05 (rank : 53)	NC score	0.386783 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	59	Shared Neighborhood Hits	43
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	5.44631e-05 (rank : 54)	NC score	0.389346 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

GAS7_HUMAN
θ value	9.29e-05 (rank : 55)	NC score	0.264395 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

YAP1_HUMAN
θ value	9.29e-05 (rank : 56)	NC score	0.379611 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	173	Shared Neighborhood Hits	62
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

GAS7_MOUSE
θ value	0.000158464 (rank : 57)	NC score	0.263479 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

RHG12_MOUSE
θ value	0.000158464 (rank : 58)	NC score	0.124012 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

APBB2_HUMAN
θ value	0.00102713 (rank : 59)	NC score	0.178827 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

RHG12_HUMAN
θ value	0.00102713 (rank : 60)	NC score	0.109883 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

STXB4_HUMAN
θ value	0.00134147 (rank : 61)	NC score	0.177936 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	616	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	0.00175202 (rank : 62)	NC score	0.178411 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	629	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

ACINU_MOUSE
θ value	0.00665767 (rank : 63)	NC score	0.039427 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	712	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

GRIN1_HUMAN
θ value	0.00869519 (rank : 64)	NC score	0.036046 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	681	Shared Neighborhood Hits	42
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SETD2_HUMAN
θ value	0.0113563 (rank : 65)	NC score	0.136995 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	412	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

TAB2_HUMAN
θ value	0.0148317 (rank : 66)	NC score	0.026144 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

TGON2_HUMAN
θ value	0.0193708 (rank : 67)	NC score	0.051037 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	1037	Shared Neighborhood Hits	62
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

APBB2_MOUSE
θ value	0.0252991 (rank : 68)	NC score	0.166925 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

TCOF_MOUSE
θ value	0.0563607 (rank : 69)	NC score	0.037477 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	471	Shared Neighborhood Hits	31
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

ANK2_HUMAN
θ value	0.0736092 (rank : 70)	NC score	0.021007 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	1615	Shared Neighborhood Hits	81
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

APBB1_HUMAN
θ value	0.0961366 (rank : 71)	NC score	0.098262 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
θ value	0.0961366 (rank : 72)	NC score	0.098110 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

SRRM2_MOUSE
θ value	0.0961366 (rank : 73)	NC score	0.041877 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	1470	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

LRP12_HUMAN
θ value	0.125558 (rank : 74)	NC score	0.008377 (rank : 195)
Query Neighborhood Hits	177	Target Neighborhood Hits	205	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

APBB3_HUMAN
θ value	0.163984 (rank : 75)	NC score	0.134114 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	0.163984 (rank : 76)	NC score	0.133465 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

RGS3_MOUSE
θ value	0.21417 (rank : 77)	NC score	0.024796 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	1621	Shared Neighborhood Hits	74
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

DMD_HUMAN
θ value	0.279714 (rank : 78)	NC score	0.046745 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	1135	Shared Neighborhood Hits	45
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	0.279714 (rank : 79)	NC score	0.042822 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	1111	Shared Neighborhood Hits	45
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

MUC2_HUMAN
θ value	0.279714 (rank : 80)	NC score	0.024742 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	906	Shared Neighborhood Hits	41
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MUC5B_HUMAN
θ value	0.279714 (rank : 81)	NC score	0.021809 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	1020	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

TCRG1_MOUSE
θ value	0.279714 (rank : 82)	NC score	0.084226 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	947	Shared Neighborhood Hits	67
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

CAC1A_MOUSE
θ value	0.365318 (rank : 83)	NC score	0.012459 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	24
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

MORN3_HUMAN
θ value	0.365318 (rank : 84)	NC score	0.027917 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

MADCA_HUMAN
θ value	0.47712 (rank : 85)	NC score	0.025375 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	221	Shared Neighborhood Hits	22
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

PTC1_MOUSE
θ value	0.47712 (rank : 86)	NC score	0.015137 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

TARA_HUMAN
θ value	0.47712 (rank : 87)	NC score	0.042223 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	1626	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

UTRO_HUMAN
θ value	0.47712 (rank : 88)	NC score	0.038830 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	960	Shared Neighborhood Hits	39
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

SRRM2_HUMAN
θ value	0.62314 (rank : 89)	NC score	0.043429 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	1296	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

WBP4_MOUSE
θ value	0.62314 (rank : 90)	NC score	0.118030 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	34
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

CO002_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.021244 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	387	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

FILA_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.021898 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	685	Shared Neighborhood Hits	33
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

SREC2_HUMAN
θ value	0.813845 (rank : 93)	NC score	0.003959 (rank : 210)
Query Neighborhood Hits	177	Target Neighborhood Hits	645	Shared Neighborhood Hits	23
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

TFE2_MOUSE
θ value	0.813845 (rank : 94)	NC score	0.010531 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

ACINU_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.034087 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

CLAP1_HUMAN
θ value	1.06291 (rank : 96)	NC score	0.014512 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z460, O75118, Q8N5B8, Q9BQT5	Gene names	CLASP1, KIAA0622, MAST1
Domain Architecture	No domain graphic available
Description	CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1).

CTTB2_HUMAN
θ value	1.06291 (rank : 97)	NC score	0.009160 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	1061	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

DRP2_HUMAN
θ value	1.06291 (rank : 98)	NC score	0.091239 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	186	Shared Neighborhood Hits	26
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

GNAS1_MOUSE
θ value	1.06291 (rank : 99)	NC score	0.014911 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	651	Shared Neighborhood Hits	34
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

HXB5_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.002695 (rank : 213)
Query Neighborhood Hits	177	Target Neighborhood Hits	337	Shared Neighborhood Hits	10
SwissProt Accessions	P09079, Q3ZAY8	Gene names	Hoxb5, Hox-2.1, Hoxb-5
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2.1) (MU-1) (H24.1).

MAGE1_HUMAN
θ value	1.06291 (rank : 101)	NC score	0.035271 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	1389	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SNPC4_HUMAN
θ value	1.06291 (rank : 102)	NC score	0.019297 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	589	Shared Neighborhood Hits	38
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

TAF9B_HUMAN
θ value	1.06291 (rank : 103)	NC score	0.029331 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HBM6, Q9Y2S3	Gene names	TAF9B, TAF9L
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 9B (Transcription initiation factor TFIID subunit 9-like protein) (Transcription- associated factor TAFII31L) (Neuronal cell death-related protein 7) (DN-7).

TAF9_MOUSE
θ value	1.06291 (rank : 104)	NC score	0.023138 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VI33, Q32P09, Q80XS3, Q9CV61	Gene names	Taf9, Taf2g
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32).

TCRG1_HUMAN
θ value	1.06291 (rank : 105)	NC score	0.083843 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	929	Shared Neighborhood Hits	62
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

DACT1_MOUSE
θ value	1.38821 (rank : 106)	NC score	0.018156 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

JPH2_HUMAN
θ value	1.38821 (rank : 107)	NC score	0.011703 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	639	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

KI67_HUMAN
θ value	1.38821 (rank : 108)	NC score	0.026680 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	581	Shared Neighborhood Hits	32
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

MILK1_HUMAN
θ value	1.38821 (rank : 109)	NC score	0.016958 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	427	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PA24A_HUMAN
θ value	1.38821 (rank : 110)	NC score	0.042864 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

SYN1_HUMAN
θ value	1.38821 (rank : 111)	NC score	0.018897 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	419	Shared Neighborhood Hits	32
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

ZO1_MOUSE
θ value	1.38821 (rank : 112)	NC score	0.027176 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	453	Shared Neighborhood Hits	28
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

E2AK3_HUMAN
θ value	1.81305 (rank : 113)	NC score	0.000769 (rank : 219)
Query Neighborhood Hits	177	Target Neighborhood Hits	859	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

FOXE2_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.004755 (rank : 208)
Query Neighborhood Hits	177	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q99526	Gene names	FOXE2
Domain Architecture
Description	Forkhead box protein E2 (HNF-3/fork head-like protein 5) (HFKL5) (HFKH4).

FXR2_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.007899 (rank : 197)
Query Neighborhood Hits	177	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

JIP3_HUMAN
θ value	1.81305 (rank : 116)	NC score	0.008586 (rank : 193)
Query Neighborhood Hits	177	Target Neighborhood Hits	1039	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

K0319_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.015004 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

SPT5H_HUMAN
θ value	1.81305 (rank : 118)	NC score	0.018575 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	436	Shared Neighborhood Hits	30
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	1.81305 (rank : 119)	NC score	0.018951 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	437	Shared Neighborhood Hits	33
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

TJAP1_HUMAN
θ value	1.81305 (rank : 120)	NC score	0.015566 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	9
SwissProt Accessions	Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7	Gene names	TJAP1, PILT, TJP4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

ZO2_HUMAN
θ value	1.81305 (rank : 121)	NC score	0.022086 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ADA19_HUMAN
θ value	2.36792 (rank : 122)	NC score	0.001740 (rank : 214)
Query Neighborhood Hits	177	Target Neighborhood Hits	381	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

AMPH_HUMAN
θ value	2.36792 (rank : 123)	NC score	0.015917 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	18
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

PA24A_MOUSE
θ value	2.36792 (rank : 124)	NC score	0.048509 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	10
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

TAF9_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.021960 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q16594, Q9BTS1	Gene names	TAF9, TAF2G, TAFII31
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32) (STAF31/32).

ZO1_HUMAN
θ value	2.36792 (rank : 126)	NC score	0.028209 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	474	Shared Neighborhood Hits	33
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

CEP68_HUMAN
θ value	3.0926 (rank : 127)	NC score	0.033494 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	128	Shared Neighborhood Hits	16
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CS007_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.014035 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	401	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

FBX34_MOUSE
θ value	3.0926 (rank : 129)	NC score	0.026670 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

HCN4_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.005199 (rank : 205)
Query Neighborhood Hits	177	Target Neighborhood Hits	303	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

MUC13_MOUSE
θ value	3.0926 (rank : 131)	NC score	0.042998 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	30
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

NU214_HUMAN
θ value	3.0926 (rank : 132)	NC score	0.044036 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	657	Shared Neighborhood Hits	37
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

SOX6_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.009167 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

SRRM1_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.031738 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	690	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

ATN1_HUMAN
θ value	4.03905 (rank : 135)	NC score	0.021314 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	676	Shared Neighborhood Hits	41
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

ATX7_HUMAN
θ value	4.03905 (rank : 136)	NC score	0.010847 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	351	Shared Neighborhood Hits	22
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

CAC1B_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.006836 (rank : 202)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAMKV_HUMAN
θ value	4.03905 (rank : 138)	NC score	-0.000825 (rank : 220)
Query Neighborhood Hits	177	Target Neighborhood Hits	1084	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CD68_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.013985 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	P34810, Q96BI7	Gene names	CD68
Domain Architecture
Description	Macrosialin precursor (GP110) (CD68 antigen).

CDT1_MOUSE
θ value	4.03905 (rank : 140)	NC score	0.011827 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

CJ006_MOUSE
θ value	4.03905 (rank : 141)	NC score	0.010707 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	141	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

MYCD_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.007138 (rank : 200)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

NCOA3_HUMAN
θ value	4.03905 (rank : 143)	NC score	0.005798 (rank : 203)
Query Neighborhood Hits	177	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NFH_MOUSE
θ value	4.03905 (rank : 144)	NC score	0.024816 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	2247	Shared Neighborhood Hits	72
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PXK_MOUSE
θ value	4.03905 (rank : 145)	NC score	0.006936 (rank : 201)
Query Neighborhood Hits	177	Target Neighborhood Hits	320	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

ASPP1_MOUSE
θ value	5.27518 (rank : 146)	NC score	0.014536 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	1244	Shared Neighborhood Hits	47
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DPOLL_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.008140 (rank : 196)
Query Neighborhood Hits	177	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

E2AK3_MOUSE
θ value	5.27518 (rank : 148)	NC score	-0.001861 (rank : 223)
Query Neighborhood Hits	177	Target Neighborhood Hits	851	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

FBX34_HUMAN
θ value	5.27518 (rank : 149)	NC score	0.011386 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWN3, Q2VPB5, Q86TY4	Gene names	FBXO34, FBX34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

IQGA3_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.007181 (rank : 199)
Query Neighborhood Hits	177	Target Neighborhood Hits	125	Shared Neighborhood Hits	8
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

LPHN2_HUMAN
θ value	5.27518 (rank : 151)	NC score	0.000833 (rank : 218)
Query Neighborhood Hits	177	Target Neighborhood Hits	136	Shared Neighborhood Hits	6
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

RBBP6_MOUSE
θ value	5.27518 (rank : 152)	NC score	0.025869 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	1014	Shared Neighborhood Hits	43
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SYN1_MOUSE
θ value	5.27518 (rank : 153)	NC score	0.014798 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	363	Shared Neighborhood Hits	27
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

UBQL1_MOUSE
θ value	5.27518 (rank : 154)	NC score	0.003874 (rank : 211)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R317, Q80V10, Q8C7T4, Q8C835, Q8K141, Q91VI8, Q9D0Z0, Q9QZM1	Gene names	Ubqln1, Plic1
Domain Architecture
Description	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1).

ABL1_MOUSE
θ value	6.88961 (rank : 155)	NC score	-0.003504 (rank : 225)
Query Neighborhood Hits	177	Target Neighborhood Hits	1178	Shared Neighborhood Hits	25
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CDX2_MOUSE
θ value	6.88961 (rank : 156)	NC score	-0.001030 (rank : 221)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	4
SwissProt Accessions	P43241	Gene names	Cdx2, Cdx-2
Domain Architecture
Description	Homeobox protein CDX-2 (Caudal-type homeobox protein 2).

CS007_MOUSE
θ value	6.88961 (rank : 157)	NC score	0.012948 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	464	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DCX_MOUSE
θ value	6.88961 (rank : 158)	NC score	0.004954 (rank : 207)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	13
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

ENAM_HUMAN
θ value	6.88961 (rank : 159)	NC score	0.008519 (rank : 194)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

MDC1_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.035740 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	1446	Shared Neighborhood Hits	69
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NACAM_MOUSE
θ value	6.88961 (rank : 161)	NC score	0.039762 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	1866	Shared Neighborhood Hits	85
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCOA1_HUMAN
θ value	6.88961 (rank : 162)	NC score	0.005088 (rank : 206)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	10
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

PASK_HUMAN
θ value	6.88961 (rank : 163)	NC score	-0.005150 (rank : 226)
Query Neighborhood Hits	177	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PTC1_HUMAN
θ value	6.88961 (rank : 164)	NC score	0.010890 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

RBBP6_HUMAN
θ value	6.88961 (rank : 165)	NC score	0.024108 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	1135	Shared Neighborhood Hits	46
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

TITIN_HUMAN
θ value	6.88961 (rank : 166)	NC score	-0.001786 (rank : 222)
Query Neighborhood Hits	177	Target Neighborhood Hits	2923	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TS13_MOUSE
θ value	6.88961 (rank : 167)	NC score	0.012898 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	10
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

WNK1_HUMAN
θ value	6.88961 (rank : 168)	NC score	-0.002969 (rank : 224)
Query Neighborhood Hits	177	Target Neighborhood Hits	1158	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ADDB_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.005623 (rank : 204)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	P35612, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691	Gene names	ADD2, ADDB
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta).

CDC20_HUMAN
θ value	8.99809 (rank : 170)	NC score	0.000846 (rank : 217)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	8
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

HXB5_HUMAN
θ value	8.99809 (rank : 171)	NC score	0.001474 (rank : 215)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	10
SwissProt Accessions	P09067, P09069	Gene names	HOXB5, HOX2A
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2A) (HHO.C10) (HU-1).

NFAC1_HUMAN
θ value	8.99809 (rank : 172)	NC score	0.003733 (rank : 212)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	18
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

NKTR_HUMAN
θ value	8.99809 (rank : 173)	NC score	0.014327 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	658	Shared Neighborhood Hits	33
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PAPOB_MOUSE
θ value	8.99809 (rank : 174)	NC score	0.004457 (rank : 209)
Query Neighborhood Hits	177	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVP6, Q9R1R3	Gene names	Papolb, Papt, Tpap
Domain Architecture
Description	Poly(A) polymerase beta (EC 2.7.7.19) (PAP beta) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase).

TTF2_HUMAN
θ value	8.99809 (rank : 175)	NC score	0.001297 (rank : 216)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

UBL7_MOUSE
θ value	8.99809 (rank : 176)	NC score	0.007434 (rank : 198)
Query Neighborhood Hits	177	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q91W67, Q9D7P5	Gene names	Ubl7
Domain Architecture
Description	Ubiquitin-like protein 7.

ZC3H6_HUMAN
θ value	8.99809 (rank : 177)	NC score	0.008982 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

ALS2_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.054646 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.052888 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CUL7_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.057319 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

DGCR8_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.063853 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DGCR8_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.061556 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

DOC2A_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.060490 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.064655 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.061983 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	12
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.060958 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	16
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

FA62A_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.073929 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.088830 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	155	Shared Neighborhood Hits	14
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

K1333_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.063777 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PA24B_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.059841 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PCLO_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.056195 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	2046	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.059325 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	2275	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RASL1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.069917 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	8
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.065997 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.062131 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	161	Shared Neighborhood Hits	10
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RCBT1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.059589 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.061190 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.065610 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.066508 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC1_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.080307 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.078332 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.082833 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.082375 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RIMS2_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.062748 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	342	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.062710 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	376	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RP3A_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.051911 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	305	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RPGR_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.082764 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.079875 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SRGEF_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.086140 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.083821 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SYT10_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.051012 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT1_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.052180 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.052179 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT5_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.053573 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	138	Shared Neighborhood Hits	11
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT7_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.051094 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.050547 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

TOLIP_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.062819 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

TOLIP_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.067436 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

UN13A_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.078233 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	285	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.080665 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.080311 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13D_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.054915 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

WBP4_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.053656 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	19
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WBS16_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.076209 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.077854 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WWC3_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.053602 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

Hits sorted by NC score

WWP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
NC score	0.994554 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	92
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP1_MOUSE
NC score	0.989701 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	138	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_MOUSE
NC score	0.988890 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	127	Shared Neighborhood Hits	75
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
NC score	0.982917 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	262	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ITCH_HUMAN
NC score	0.981269 (rank : 6)	θ value	0 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	162	Shared Neighborhood Hits	77
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

SMUF2_HUMAN
NC score	0.960257 (rank : 7)	θ value	1.09172e-138 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.952464 (rank : 8)	θ value	1.38424e-125 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF1_HUMAN
NC score	0.949381 (rank : 9)	θ value	2.69525e-129 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

NEDD4_MOUSE
NC score	0.914429 (rank : 10)	θ value	2.689e-137 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	212	Shared Neighborhood Hits	77
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NEDD4_HUMAN
NC score	0.910956 (rank : 11)	θ value	2.19465e-147 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	76
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.896247 (rank : 12)	θ value	4.00889e-141 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	231	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.895218 (rank : 13)	θ value	1.7995e-141 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	238	Shared Neighborhood Hits	81
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

HECD2_MOUSE
NC score	0.883743 (rank : 14)	θ value	4.85792e-54 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.880868 (rank : 15)	θ value	3.48141e-52 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_HUMAN
NC score	0.877651 (rank : 16)	θ value	5.73848e-55 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

K0317_HUMAN
NC score	0.877348 (rank : 17)	θ value	1.46268e-50 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.876735 (rank : 18)	θ value	7.25919e-50 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_MOUSE
NC score	0.871250 (rank : 19)	θ value	6.56568e-51 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HUWE1_MOUSE
NC score	0.868745 (rank : 20)	θ value	1.14559e-87 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	406	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.867338 (rank : 21)	θ value	1.14559e-87 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	443	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

UBE3C_HUMAN
NC score	0.859351 (rank : 22)	θ value	1.19932e-44 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.857764 (rank : 23)	θ value	1.73182e-43 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.800429 (rank : 24)	θ value	2.50655e-34 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	319	Shared Neighborhood Hits	57
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
NC score	0.729475 (rank : 25)	θ value	4.00176e-32 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.726219 (rank : 26)	θ value	8.59492e-43 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD3_MOUSE
NC score	0.695291 (rank : 27)	θ value	2.7842e-17 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.689948 (rank : 28)	θ value	1.80466e-16 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.652745 (rank : 29)	θ value	2.20605e-14 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.651108 (rank : 30)	θ value	2.20605e-14 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HERC2_MOUSE
NC score	0.618082 (rank : 31)	θ value	6.38894e-30 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	40
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.613846 (rank : 32)	θ value	2.42779e-29 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.564506 (rank : 33)	θ value	6.18819e-25 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	371	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

YAP1_MOUSE
NC score	0.556640 (rank : 34)	θ value	1.86753e-13 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	56
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
NC score	0.531324 (rank : 35)	θ value	5.08577e-11 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.530832 (rank : 36)	θ value	5.08577e-11 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

PINL_HUMAN
NC score	0.450527 (rank : 37)	θ value	3.19293e-05 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	44
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWC1_HUMAN
NC score	0.448407 (rank : 38)	θ value	8.38298e-14 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.447398 (rank : 39)	θ value	8.38298e-14 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
NC score	0.398353 (rank : 40)	θ value	4.16044e-13 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.394927 (rank : 41)	θ value	4.16044e-13 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

PIN1_MOUSE
NC score	0.389346 (rank : 42)	θ value	5.44631e-05 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_HUMAN
NC score	0.386783 (rank : 43)	θ value	5.44631e-05 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	59	Shared Neighborhood Hits	43
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWTR1_MOUSE
NC score	0.382767 (rank : 44)	θ value	3.19293e-05 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.380441 (rank : 45)	θ value	3.19293e-05 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.379611 (rank : 46)	θ value	9.29e-05 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	173	Shared Neighborhood Hits	62
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_HUMAN
NC score	0.356333 (rank : 47)	θ value	2.44474e-05 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	57
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

MAGI2_MOUSE
NC score	0.329602 (rank : 48)	θ value	9.26847e-13 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	370	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.315267 (rank : 49)	θ value	1.9326e-10 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	373	Shared Neighborhood Hits	51
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

BAG3_MOUSE
NC score	0.312192 (rank : 50)	θ value	2.44474e-05 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	513	Shared Neighborhood Hits	73
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

MAGI1_HUMAN
NC score	0.311045 (rank : 51)	θ value	4.16044e-13 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	388	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.311034 (rank : 52)	θ value	7.09661e-13 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	403	Shared Neighborhood Hits	68
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PKHA5_HUMAN
NC score	0.284385 (rank : 53)	θ value	3.08544e-08 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAS7_HUMAN
NC score	0.264395 (rank : 54)	θ value	9.29e-05 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.263479 (rank : 55)	θ value	0.000158464 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PRP40_HUMAN
NC score	0.219659 (rank : 56)	θ value	4.1701e-05 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	442	Shared Neighborhood Hits	49
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.219016 (rank : 57)	θ value	1.43324e-05 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

APBB2_HUMAN
NC score	0.178827 (rank : 58)	θ value	0.00102713 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

STXB4_MOUSE
NC score	0.178411 (rank : 59)	θ value	0.00175202 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	629	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.177936 (rank : 60)	θ value	0.00134147 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	616	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBB2_MOUSE
NC score	0.166925 (rank : 61)	θ value	0.0252991 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

SETD2_HUMAN
NC score	0.136995 (rank : 62)	θ value	0.0113563 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	412	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

APBB3_HUMAN
NC score	0.134114 (rank : 63)	θ value	0.163984 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
NC score	0.133465 (rank : 64)	θ value	0.163984 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

RHG12_MOUSE
NC score	0.124012 (rank : 65)	θ value	0.000158464 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

WBP4_MOUSE
NC score	0.118030 (rank : 66)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	34
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

RHG12_HUMAN
NC score	0.109883 (rank : 67)	θ value	0.00102713 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

APBB1_HUMAN
NC score	0.098262 (rank : 68)	θ value	0.0961366 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.098110 (rank : 69)	θ value	0.0961366 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

DRP2_HUMAN
NC score	0.091239 (rank : 70)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	186	Shared Neighborhood Hits	26
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

FA62A_MOUSE
NC score	0.088830 (rank : 71)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	155	Shared Neighborhood Hits	14
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SRGEF_HUMAN
NC score	0.086140 (rank : 72)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	177	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

TCRG1_MOUSE
NC score	0.084226 (rank : 73)	θ value	0.279714 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	947	Shared Neighborhood Hits	67
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TCRG1_HUMAN
NC score	0.083843 (rank : 74)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	929	Shared Neighborhood Hits	62
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

SRGEF_MOUSE
NC score	0.083821 (rank : 75)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RCC2_HUMAN
NC score	0.082833 (rank : 76)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RPGR_HUMAN
NC score	0.082764 (rank : 77)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	177	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCC2_MOUSE
NC score	0.082375 (rank : 78)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

UN13B_HUMAN
NC score	0.080665 (rank : 79)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
NC score	0.080311 (rank : 80)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	177	Target Neighborhood Hits	210	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

RCC1_HUMAN
NC score	0.080307 (rank : 81)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RPGR_MOUSE
NC score	0.079875 (rank : 82)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	177	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RCC1_MOUSE
NC score	0.078332 (rank : 83)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

UN13A_HUMAN
NC score	0.078233 (rank : 84)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	177	Target Neighborhood Hits	285	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

WBS16_MOUSE
NC score	0.077854 (rank : 85)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	177	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WBS16_HUMAN
NC score	0.076209 (rank : 86)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	177	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

FA62A_HUMAN
NC score	0.073929 (rank : 87)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RASL1_HUMAN
NC score	0.069917 (rank : 88)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	8
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

TOLIP_MOUSE
NC score	0.067436 (rank : 89)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	177	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

RCBT2_MOUSE
NC score	0.066508 (rank : 90)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RASL1_MOUSE
NC score	0.065997 (rank : 91)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	177	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RCBT2_HUMAN
NC score	0.065610 (rank : 92)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

DOC2A_MOUSE
NC score	0.064655 (rank : 93)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DGCR8_HUMAN
NC score	0.063853 (rank : 94)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

K1333_MOUSE
NC score	0.063777 (rank : 95)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

TOLIP_HUMAN
NC score	0.062819 (rank : 96)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	177	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

RIMS2_HUMAN
NC score	0.062748 (rank : 97)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	177	Target Neighborhood Hits	342	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.062710 (rank : 98)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	177	Target Neighborhood Hits	376	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RASL2_HUMAN
NC score	0.062131 (rank : 99)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	177	Target Neighborhood Hits	161	Shared Neighborhood Hits	10
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

DOC2B_HUMAN
NC score	0.061983 (rank : 100)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	12
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DGCR8_MOUSE
NC score	0.061556 (rank : 101)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

RCBT1_MOUSE
NC score	0.061190 (rank : 102)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

DOC2B_MOUSE
NC score	0.060958 (rank : 103)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	16
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_HUMAN
NC score	0.060490 (rank : 104)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

PA24B_MOUSE
NC score	0.059841 (rank : 105)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RCBT1_HUMAN
NC score	0.059589 (rank : 106)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

PCLO_MOUSE
NC score	0.059325 (rank : 107)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	2275	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CUL7_HUMAN
NC score	0.057319 (rank : 108)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

PCLO_HUMAN
NC score	0.056195 (rank : 109)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	2046	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

UN13D_HUMAN
NC score	0.054915 (rank : 110)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

ALS2_HUMAN
NC score	0.054646 (rank : 111)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

WBP4_HUMAN
NC score	0.053656 (rank : 112)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	19
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WWC3_HUMAN
NC score	0.053602 (rank : 113)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	177	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

SYT5_HUMAN
NC score	0.053573 (rank : 114)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	177	Target Neighborhood Hits	138	Shared Neighborhood Hits	11
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

ALS2_MOUSE
NC score	0.052888 (rank : 115)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SYT1_HUMAN
NC score	0.052180 (rank : 116)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.052179 (rank : 117)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	11
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

RP3A_HUMAN
NC score	0.051911 (rank : 118)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	177	Target Neighborhood Hits	305	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT7_HUMAN
NC score	0.051094 (rank : 119)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

TGON2_HUMAN
NC score	0.051037 (rank : 120)	θ value	0.0193708 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	1037	Shared Neighborhood Hits	62
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

SYT10_HUMAN
NC score	0.051012 (rank : 121)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	177	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT7_MOUSE
NC score	0.050547 (rank : 122)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

PA24A_MOUSE
NC score	0.048509 (rank : 123)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	10
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

DMD_HUMAN
NC score	0.046745 (rank : 124)	θ value	0.279714 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	1135	Shared Neighborhood Hits	45
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

NU214_HUMAN
NC score	0.044036 (rank : 125)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	657	Shared Neighborhood Hits	37
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

SRRM2_HUMAN
NC score	0.043429 (rank : 126)	θ value	0.62314 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	1296	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

MUC13_MOUSE
NC score	0.042998 (rank : 127)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	30
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

PA24A_HUMAN
NC score	0.042864 (rank : 128)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

DMD_MOUSE
NC score	0.042822 (rank : 129)	θ value	0.279714 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	1111	Shared Neighborhood Hits	45
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

TARA_HUMAN
NC score	0.042223 (rank : 130)	θ value	0.47712 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	1626	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SRRM2_MOUSE
NC score	0.041877 (rank : 131)	θ value	0.0961366 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	1470	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

NACAM_MOUSE
NC score	0.039762 (rank : 132)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	1866	Shared Neighborhood Hits	85
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ACINU_MOUSE
NC score	0.039427 (rank : 133)	θ value	0.00665767 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	712	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

UTRO_HUMAN
NC score	0.038830 (rank : 134)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	960	Shared Neighborhood Hits	39
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

TCOF_MOUSE
NC score	0.037477 (rank : 135)	θ value	0.0563607 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	471	Shared Neighborhood Hits	31
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

GRIN1_HUMAN
NC score	0.036046 (rank : 136)	θ value	0.00869519 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	681	Shared Neighborhood Hits	42
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

MDC1_HUMAN
NC score	0.035740 (rank : 137)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	1446	Shared Neighborhood Hits	69
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MAGE1_HUMAN
NC score	0.035271 (rank : 138)	θ value	1.06291 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	1389	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

ACINU_HUMAN
NC score	0.034087 (rank : 139)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

CEP68_HUMAN
NC score	0.033494 (rank : 140)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	128	Shared Neighborhood Hits	16
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

SRRM1_HUMAN
NC score	0.031738 (rank : 141)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	690	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

TAF9B_HUMAN
NC score	0.029331 (rank : 142)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HBM6, Q9Y2S3	Gene names	TAF9B, TAF9L
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 9B (Transcription initiation factor TFIID subunit 9-like protein) (Transcription- associated factor TAFII31L) (Neuronal cell death-related protein 7) (DN-7).

ZO1_HUMAN
NC score	0.028209 (rank : 143)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	474	Shared Neighborhood Hits	33
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MORN3_HUMAN
NC score	0.027917 (rank : 144)	θ value	0.365318 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

ZO1_MOUSE
NC score	0.027176 (rank : 145)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	453	Shared Neighborhood Hits	28
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

KI67_HUMAN
NC score	0.026680 (rank : 146)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	581	Shared Neighborhood Hits	32
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

FBX34_MOUSE
NC score	0.026670 (rank : 147)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

TAB2_HUMAN
NC score	0.026144 (rank : 148)	θ value	0.0148317 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

RBBP6_MOUSE
NC score	0.025869 (rank : 149)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	1014	Shared Neighborhood Hits	43
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

MADCA_HUMAN
NC score	0.025375 (rank : 150)	θ value	0.47712 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	221	Shared Neighborhood Hits	22
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

NFH_MOUSE
NC score	0.024816 (rank : 151)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	2247	Shared Neighborhood Hits	72
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RGS3_MOUSE
NC score	0.024796 (rank : 152)	θ value	0.21417 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	1621	Shared Neighborhood Hits	74
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

MUC2_HUMAN
NC score	0.024742 (rank : 153)	θ value	0.279714 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	906	Shared Neighborhood Hits	41
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

RBBP6_HUMAN
NC score	0.024108 (rank : 154)	θ value	6.88961 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	1135	Shared Neighborhood Hits	46
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

TAF9_MOUSE
NC score	0.023138 (rank : 155)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VI33, Q32P09, Q80XS3, Q9CV61	Gene names	Taf9, Taf2g
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32).

ZO2_HUMAN
NC score	0.022086 (rank : 156)	θ value	1.81305 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

TAF9_HUMAN
NC score	0.021960 (rank : 157)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q16594, Q9BTS1	Gene names	TAF9, TAF2G, TAFII31
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32) (STAF31/32).

FILA_HUMAN
NC score	0.021898 (rank : 158)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	685	Shared Neighborhood Hits	33
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

MUC5B_HUMAN
NC score	0.021809 (rank : 159)	θ value	0.279714 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	1020	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

ATN1_HUMAN
NC score	0.021314 (rank : 160)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	676	Shared Neighborhood Hits	41
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

CO002_HUMAN
NC score	0.021244 (rank : 161)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	387	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

ANK2_HUMAN
NC score	0.021007 (rank : 162)	θ value	0.0736092 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	1615	Shared Neighborhood Hits	81
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

SNPC4_HUMAN
NC score	0.019297 (rank : 163)	θ value	1.06291 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	589	Shared Neighborhood Hits	38
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SPT5H_MOUSE
NC score	0.018951 (rank : 164)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	437	Shared Neighborhood Hits	33
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SYN1_HUMAN
NC score	0.018897 (rank : 165)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	419	Shared Neighborhood Hits	32
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

SPT5H_HUMAN
NC score	0.018575 (rank : 166)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	436	Shared Neighborhood Hits	30
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

DACT1_MOUSE
NC score	0.018156 (rank : 167)	θ value	1.38821 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

MILK1_HUMAN
NC score	0.016958 (rank : 168)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	427	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

AMPH_HUMAN
NC score	0.015917 (rank : 169)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	18
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

TJAP1_HUMAN
NC score	0.015566 (rank : 170)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	9
SwissProt Accessions	Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7	Gene names	TJAP1, PILT, TJP4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

PTC1_MOUSE
NC score	0.015137 (rank : 171)	θ value	0.47712 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

K0319_HUMAN
NC score	0.015004 (rank : 172)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

GNAS1_MOUSE
NC score	0.014911 (rank : 173)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	651	Shared Neighborhood Hits	34
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

SYN1_MOUSE
NC score	0.014798 (rank : 174)	θ value	5.27518 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	363	Shared Neighborhood Hits	27
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

ASPP1_MOUSE
NC score	0.014536 (rank : 175)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	1244	Shared Neighborhood Hits	47
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CLAP1_HUMAN
NC score	0.014512 (rank : 176)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z460, O75118, Q8N5B8, Q9BQT5	Gene names	CLASP1, KIAA0622, MAST1
Domain Architecture	No domain graphic available
Description	CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1).

NKTR_HUMAN
NC score	0.014327 (rank : 177)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	658	Shared Neighborhood Hits	33
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

CS007_HUMAN
NC score	0.014035 (rank : 178)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	401	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

CD68_HUMAN
NC score	0.013985 (rank : 179)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	P34810, Q96BI7	Gene names	CD68
Domain Architecture
Description	Macrosialin precursor (GP110) (CD68 antigen).

CS007_MOUSE
NC score	0.012948 (rank : 180)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	464	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

TS13_MOUSE
NC score	0.012898 (rank : 181)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	10
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

CAC1A_MOUSE
NC score	0.012459 (rank : 182)	θ value	0.365318 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	24
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CDT1_MOUSE
NC score	0.011827 (rank : 183)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

JPH2_HUMAN
NC score	0.011703 (rank : 184)	θ value	1.38821 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	639	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

FBX34_HUMAN
NC score	0.011386 (rank : 185)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWN3, Q2VPB5, Q86TY4	Gene names	FBXO34, FBX34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

PTC1_HUMAN
NC score	0.010890 (rank : 186)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

ATX7_HUMAN
NC score	0.010847 (rank : 187)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	351	Shared Neighborhood Hits	22
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

CJ006_MOUSE
NC score	0.010707 (rank : 188)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	141	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

TFE2_MOUSE
NC score	0.010531 (rank : 189)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

SOX6_MOUSE
NC score	0.009167 (rank : 190)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

CTTB2_HUMAN
NC score	0.009160 (rank : 191)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	1061	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

ZC3H6_HUMAN
NC score	0.008982 (rank : 192)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

JIP3_HUMAN
NC score	0.008586 (rank : 193)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	1039	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

ENAM_HUMAN
NC score	0.008519 (rank : 194)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

LRP12_HUMAN
NC score	0.008377 (rank : 195)	θ value	0.125558 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	205	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

DPOLL_MOUSE
NC score	0.008140 (rank : 196)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

FXR2_MOUSE
NC score	0.007899 (rank : 197)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

UBL7_MOUSE
NC score	0.007434 (rank : 198)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q91W67, Q9D7P5	Gene names	Ubl7
Domain Architecture
Description	Ubiquitin-like protein 7.

IQGA3_HUMAN
NC score	0.007181 (rank : 199)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	125	Shared Neighborhood Hits	8
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

MYCD_HUMAN
NC score	0.007138 (rank : 200)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

PXK_MOUSE
NC score	0.006936 (rank : 201)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	320	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

CAC1B_HUMAN
NC score	0.006836 (rank : 202)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

NCOA3_HUMAN
NC score	0.005798 (rank : 203)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

ADDB_HUMAN
NC score	0.005623 (rank : 204)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	P35612, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691	Gene names	ADD2, ADDB
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta).

HCN4_HUMAN
NC score	0.005199 (rank : 205)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	303	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

NCOA1_HUMAN
NC score	0.005088 (rank : 206)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	10
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

DCX_MOUSE
NC score	0.004954 (rank : 207)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	13
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

FOXE2_HUMAN
NC score	0.004755 (rank : 208)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q99526	Gene names	FOXE2
Domain Architecture
Description	Forkhead box protein E2 (HNF-3/fork head-like protein 5) (HFKL5) (HFKH4).

PAPOB_MOUSE
NC score	0.004457 (rank : 209)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVP6, Q9R1R3	Gene names	Papolb, Papt, Tpap
Domain Architecture
Description	Poly(A) polymerase beta (EC 2.7.7.19) (PAP beta) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase).

SREC2_HUMAN
NC score	0.003959 (rank : 210)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	645	Shared Neighborhood Hits	23
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

UBQL1_MOUSE
NC score	0.003874 (rank : 211)	θ value	5.27518 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R317, Q80V10, Q8C7T4, Q8C835, Q8K141, Q91VI8, Q9D0Z0, Q9QZM1	Gene names	Ubqln1, Plic1
Domain Architecture
Description	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1).

NFAC1_HUMAN
NC score	0.003733 (rank : 212)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	18
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

HXB5_MOUSE
NC score	0.002695 (rank : 213)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	337	Shared Neighborhood Hits	10
SwissProt Accessions	P09079, Q3ZAY8	Gene names	Hoxb5, Hox-2.1, Hoxb-5
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2.1) (MU-1) (H24.1).

ADA19_HUMAN
NC score	0.001740 (rank : 214)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	381	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

HXB5_HUMAN
NC score	0.001474 (rank : 215)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	10
SwissProt Accessions	P09067, P09069	Gene names	HOXB5, HOX2A
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2A) (HHO.C10) (HU-1).

TTF2_HUMAN
NC score	0.001297 (rank : 216)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

CDC20_HUMAN
NC score	0.000846 (rank : 217)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	8
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

LPHN2_HUMAN
NC score	0.000833 (rank : 218)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	136	Shared Neighborhood Hits	6
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

E2AK3_HUMAN
NC score	0.000769 (rank : 219)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	859	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

CAMKV_HUMAN
NC score	-0.000825 (rank : 220)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	1084	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CDX2_MOUSE
NC score	-0.001030 (rank : 221)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	4
SwissProt Accessions	P43241	Gene names	Cdx2, Cdx-2
Domain Architecture
Description	Homeobox protein CDX-2 (Caudal-type homeobox protein 2).

TITIN_HUMAN
NC score	-0.001786 (rank : 222)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	2923	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

E2AK3_MOUSE
NC score	-0.001861 (rank : 223)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	851	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

WNK1_HUMAN
NC score	-0.002969 (rank : 224)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	1158	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ABL1_MOUSE
NC score	-0.003504 (rank : 225)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	1178	Shared Neighborhood Hits	25
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

PASK_HUMAN
NC score	-0.005150 (rank : 226)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).