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Network neighborhood for query Sequence : SRGEF_HUMAN

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SRGEF_HUMAN
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SRGEF_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	33	Target Neighborhood Hits	33	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	0 (rank : 2)	NC score	0.997082 (rank : 2)
Query Neighborhood Hits	33	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

HERC3_HUMAN
θ value	1.32909e-35 (rank : 3)	NC score	0.625096 (rank : 16)
Query Neighborhood Hits	33	Target Neighborhood Hits	62	Shared Neighborhood Hits	30
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC2_HUMAN
θ value	9.2256e-29 (rank : 4)	NC score	0.625349 (rank : 15)
Query Neighborhood Hits	33	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	2.68423e-28 (rank : 5)	NC score	0.622408 (rank : 17)
Query Neighborhood Hits	33	Target Neighborhood Hits	167	Shared Neighborhood Hits	30
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

RPGR_MOUSE
θ value	4.57862e-28 (rank : 6)	NC score	0.807070 (rank : 7)
Query Neighborhood Hits	33	Target Neighborhood Hits	281	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RPGR_HUMAN
θ value	8.63488e-27 (rank : 7)	NC score	0.803164 (rank : 8)
Query Neighborhood Hits	33	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCBT2_MOUSE
θ value	1.99067e-23 (rank : 8)	NC score	0.719223 (rank : 12)
Query Neighborhood Hits	33	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCBT2_HUMAN
θ value	2.87452e-22 (rank : 9)	NC score	0.723830 (rank : 11)
Query Neighborhood Hits	33	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT1_MOUSE
θ value	4.9032e-22 (rank : 10)	NC score	0.691004 (rank : 14)
Query Neighborhood Hits	33	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT1_HUMAN
θ value	8.36355e-22 (rank : 11)	NC score	0.692526 (rank : 13)
Query Neighborhood Hits	33	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

NEK8_MOUSE
θ value	4.58923e-20 (rank : 12)	NC score	0.205991 (rank : 27)
Query Neighborhood Hits	33	Target Neighborhood Hits	872	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

RCC1_HUMAN
θ value	1.33526e-19 (rank : 13)	NC score	0.835366 (rank : 3)
Query Neighborhood Hits	33	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC2_MOUSE
θ value	2.97466e-19 (rank : 14)	NC score	0.828163 (rank : 4)
Query Neighborhood Hits	33	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

HERC5_HUMAN
θ value	5.07402e-19 (rank : 15)	NC score	0.594084 (rank : 18)
Query Neighborhood Hits	33	Target Neighborhood Hits	66	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

RCC2_HUMAN
θ value	5.60996e-18 (rank : 16)	NC score	0.826834 (rank : 6)
Query Neighborhood Hits	33	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC1_MOUSE
θ value	7.32683e-18 (rank : 17)	NC score	0.827840 (rank : 5)
Query Neighborhood Hits	33	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

NEK9_MOUSE
θ value	8.10077e-17 (rank : 18)	NC score	0.215077 (rank : 25)
Query Neighborhood Hits	33	Target Neighborhood Hits	890	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK9_HUMAN
θ value	1.38178e-16 (rank : 19)	NC score	0.212359 (rank : 26)
Query Neighborhood Hits	33	Target Neighborhood Hits	900	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK8_HUMAN
θ value	1.80466e-16 (rank : 20)	NC score	0.202435 (rank : 28)
Query Neighborhood Hits	33	Target Neighborhood Hits	872	Shared Neighborhood Hits	29
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

WBS16_MOUSE
θ value	1.16975e-15 (rank : 21)	NC score	0.799045 (rank : 9)
Query Neighborhood Hits	33	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WBS16_HUMAN
θ value	4.44505e-15 (rank : 22)	NC score	0.794950 (rank : 10)
Query Neighborhood Hits	33	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

ALS2_MOUSE
θ value	8.11959e-09 (rank : 23)	NC score	0.537892 (rank : 19)
Query Neighborhood Hits	33	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
θ value	1.80886e-08 (rank : 24)	NC score	0.536960 (rank : 20)
Query Neighborhood Hits	33	Target Neighborhood Hits	121	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

MYCB2_HUMAN
θ value	1.29631e-06 (rank : 25)	NC score	0.421351 (rank : 21)
Query Neighborhood Hits	33	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYCB2_MOUSE
θ value	4.92598e-06 (rank : 26)	NC score	0.418747 (rank : 22)
Query Neighborhood Hits	33	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

EDD1_HUMAN
θ value	0.47712 (rank : 27)	NC score	0.114804 (rank : 35)
Query Neighborhood Hits	33	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

FBX24_HUMAN
θ value	0.62314 (rank : 28)	NC score	0.299321 (rank : 23)
Query Neighborhood Hits	33	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

FBX24_MOUSE
θ value	0.813845 (rank : 29)	NC score	0.262754 (rank : 24)
Query Neighborhood Hits	33	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

EDD1_MOUSE
θ value	1.06291 (rank : 30)	NC score	0.111868 (rank : 36)
Query Neighborhood Hits	33	Target Neighborhood Hits	167	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

FKBP5_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.009216 (rank : 76)
Query Neighborhood Hits	33	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	Q13451	Gene names	FKBP5, AIG6, FKBP51
Domain Architecture
Description	FK506-binding protein 5 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (51 kDa FK506-binding protein) (FKBP- 51) (54 kDa progesterone receptor-associated immunophilin) (FKBP54) (P54) (FF1 antigen) (HSP90-binding immunophilin) (Androgen-regulated protein 6).

EPHA2_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.015594 (rank : 75)
Query Neighborhood Hits	33	Target Neighborhood Hits	1021	Shared Neighborhood Hits	7
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

USH2A_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.000817 (rank : 77)
Query Neighborhood Hits	33	Target Neighborhood Hits	600	Shared Neighborhood Hits	3
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

ABTB1_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.050935 (rank : 73)
Query Neighborhood Hits	33	Target Neighborhood Hits	325	Shared Neighborhood Hits	4
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

ABTB1_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.050019 (rank : 74)
Query Neighborhood Hits	33	Target Neighborhood Hits	349	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

ABTB2_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.061989 (rank : 63)
Query Neighborhood Hits	33	Target Neighborhood Hits	391	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.061958 (rank : 64)
Query Neighborhood Hits	33	Target Neighborhood Hits	414	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

BTBD2_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.056525 (rank : 69)
Query Neighborhood Hits	33	Target Neighborhood Hits	161	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BX70, O60418, O75248, Q7Z5W0, Q96SX8, Q9NPS1, Q9NX81	Gene names	BTBD2
Domain Architecture
Description	BTB/POZ domain-containing protein 2.

BTBD3_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.058632 (rank : 68)
Query Neighborhood Hits	33	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2F9	Gene names	BTBD3, KIAA0952
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

BTBD3_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.059142 (rank : 67)
Query Neighborhood Hits	33	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	P58545	Gene names	Btbd3
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

BTBD6_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.051334 (rank : 71)
Query Neighborhood Hits	33	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q96KE9, Q8IVQ7, Q9BR94	Gene names	BTBD6, BDPL
Domain Architecture
Description	BTB/POZ domain-containing protein 6 (Lens BTB domain protein).

BTBD6_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.052557 (rank : 70)
Query Neighborhood Hits	33	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K2J9	Gene names	Btbd6
Domain Architecture
Description	BTB/POZ domain-containing protein 6.

BTBD8_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.071598 (rank : 58)
Query Neighborhood Hits	33	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q5XKL5, Q6V9S5	Gene names	BTBD8
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 8.

BTBDC_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.067442 (rank : 59)
Query Neighborhood Hits	33	Target Neighborhood Hits	248	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CUL7_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.064084 (rank : 62)
Query Neighborhood Hits	33	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

HECD1_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.073536 (rank : 57)
Query Neighborhood Hits	33	Target Neighborhood Hits	371	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD2_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.117605 (rank : 33)
Query Neighborhood Hits	33	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.116316 (rank : 34)
Query Neighborhood Hits	33	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.133522 (rank : 29)
Query Neighborhood Hits	33	Target Neighborhood Hits	49	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.133461 (rank : 30)
Query Neighborhood Hits	33	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HUWE1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.094788 (rank : 41)
Query Neighborhood Hits	33	Target Neighborhood Hits	443	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.095956 (rank : 40)
Query Neighborhood Hits	33	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ITCH_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.090856 (rank : 46)
Query Neighborhood Hits	33	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.091591 (rank : 45)
Query Neighborhood Hits	33	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

K0317_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.082142 (rank : 56)
Query Neighborhood Hits	33	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.082192 (rank : 55)
Query Neighborhood Hits	33	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

LZTR1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.067199 (rank : 60)
Query Neighborhood Hits	33	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N653, Q14776	Gene names	LZTR1, TCFL2
Domain Architecture
Description	Leucine-zipper-like transcriptional regulator 1 (LZTR-1).

LZTR1_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.067085 (rank : 61)
Query Neighborhood Hits	33	Target Neighborhood Hits	200	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CQ33	Gene names	Lztr1, Tcfl2
Domain Architecture
Description	Leucine-zipper-like transcriptional regulator 1 (LZTR-1).

NED4L_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.084703 (rank : 53)
Query Neighborhood Hits	33	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.084830 (rank : 52)
Query Neighborhood Hits	33	Target Neighborhood Hits	231	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.083774 (rank : 54)
Query Neighborhood Hits	33	Target Neighborhood Hits	214	Shared Neighborhood Hits	6
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.085487 (rank : 51)
Query Neighborhood Hits	33	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PARC_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.051013 (rank : 72)
Query Neighborhood Hits	33	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

RHBT3_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.060857 (rank : 65)
Query Neighborhood Hits	33	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	O94955, Q8IW06	Gene names	RHOBTB3, KIAA0878
Domain Architecture
Description	Rho-related BTB domain-containing protein 3.

RHBT3_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.060580 (rank : 66)
Query Neighborhood Hits	33	Target Neighborhood Hits	120	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CTN4, Q80X55, Q9CVT0	Gene names	Rhobtb3, Kiaa0878
Domain Architecture
Description	Rho-related BTB domain-containing protein 3.

SMUF1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.093372 (rank : 43)
Query Neighborhood Hits	33	Target Neighborhood Hits	135	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.092947 (rank : 44)
Query Neighborhood Hits	33	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.093383 (rank : 42)
Query Neighborhood Hits	33	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

TRIPC_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.100500 (rank : 39)
Query Neighborhood Hits	33	Target Neighborhood Hits	319	Shared Neighborhood Hits	7
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.120431 (rank : 31)
Query Neighborhood Hits	33	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.120229 (rank : 32)
Query Neighborhood Hits	33	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.101492 (rank : 37)
Query Neighborhood Hits	33	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.101148 (rank : 38)
Query Neighborhood Hits	33	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WWP1_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.085773 (rank : 50)
Query Neighborhood Hits	33	Target Neighborhood Hits	262	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.086761 (rank : 48)
Query Neighborhood Hits	33	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.086140 (rank : 49)
Query Neighborhood Hits	33	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.087886 (rank : 47)
Query Neighborhood Hits	33	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

Hits sorted by NC score

SRGEF_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	33	Target Neighborhood Hits	33	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
NC score	0.997082 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	33	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RCC1_HUMAN
NC score	0.835366 (rank : 3)	θ value	1.33526e-19 (rank : 13)
Query Neighborhood Hits	33	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC2_MOUSE
NC score	0.828163 (rank : 4)	θ value	2.97466e-19 (rank : 14)
Query Neighborhood Hits	33	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RCC1_MOUSE
NC score	0.827840 (rank : 5)	θ value	7.32683e-18 (rank : 17)
Query Neighborhood Hits	33	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
NC score	0.826834 (rank : 6)	θ value	5.60996e-18 (rank : 16)
Query Neighborhood Hits	33	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RPGR_MOUSE
NC score	0.807070 (rank : 7)	θ value	4.57862e-28 (rank : 6)
Query Neighborhood Hits	33	Target Neighborhood Hits	281	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RPGR_HUMAN
NC score	0.803164 (rank : 8)	θ value	8.63488e-27 (rank : 7)
Query Neighborhood Hits	33	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

WBS16_MOUSE
NC score	0.799045 (rank : 9)	θ value	1.16975e-15 (rank : 21)
Query Neighborhood Hits	33	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WBS16_HUMAN
NC score	0.794950 (rank : 10)	θ value	4.44505e-15 (rank : 22)
Query Neighborhood Hits	33	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

RCBT2_HUMAN
NC score	0.723830 (rank : 11)	θ value	2.87452e-22 (rank : 9)
Query Neighborhood Hits	33	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
NC score	0.719223 (rank : 12)	θ value	1.99067e-23 (rank : 8)
Query Neighborhood Hits	33	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCBT1_HUMAN
NC score	0.692526 (rank : 13)	θ value	8.36355e-22 (rank : 11)
Query Neighborhood Hits	33	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
NC score	0.691004 (rank : 14)	θ value	4.9032e-22 (rank : 10)
Query Neighborhood Hits	33	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

HERC2_HUMAN
NC score	0.625349 (rank : 15)	θ value	9.2256e-29 (rank : 4)
Query Neighborhood Hits	33	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
NC score	0.625096 (rank : 16)	θ value	1.32909e-35 (rank : 3)
Query Neighborhood Hits	33	Target Neighborhood Hits	62	Shared Neighborhood Hits	30
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC2_MOUSE
NC score	0.622408 (rank : 17)	θ value	2.68423e-28 (rank : 5)
Query Neighborhood Hits	33	Target Neighborhood Hits	167	Shared Neighborhood Hits	30
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC5_HUMAN
NC score	0.594084 (rank : 18)	θ value	5.07402e-19 (rank : 15)
Query Neighborhood Hits	33	Target Neighborhood Hits	66	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

ALS2_MOUSE
NC score	0.537892 (rank : 19)	θ value	8.11959e-09 (rank : 23)
Query Neighborhood Hits	33	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
NC score	0.536960 (rank : 20)	θ value	1.80886e-08 (rank : 24)
Query Neighborhood Hits	33	Target Neighborhood Hits	121	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

MYCB2_HUMAN
NC score	0.421351 (rank : 21)	θ value	1.29631e-06 (rank : 25)
Query Neighborhood Hits	33	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYCB2_MOUSE
NC score	0.418747 (rank : 22)	θ value	4.92598e-06 (rank : 26)
Query Neighborhood Hits	33	Target Neighborhood Hits	307	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

FBX24_HUMAN
NC score	0.299321 (rank : 23)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	33	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

FBX24_MOUSE
NC score	0.262754 (rank : 24)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	33	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

NEK9_MOUSE
NC score	0.215077 (rank : 25)	θ value	8.10077e-17 (rank : 18)
Query Neighborhood Hits	33	Target Neighborhood Hits	890	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK9_HUMAN
NC score	0.212359 (rank : 26)	θ value	1.38178e-16 (rank : 19)
Query Neighborhood Hits	33	Target Neighborhood Hits	900	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK8_MOUSE
NC score	0.205991 (rank : 27)	θ value	4.58923e-20 (rank : 12)
Query Neighborhood Hits	33	Target Neighborhood Hits	872	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK8_HUMAN
NC score	0.202435 (rank : 28)	θ value	1.80466e-16 (rank : 20)
Query Neighborhood Hits	33	Target Neighborhood Hits	872	Shared Neighborhood Hits	29
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

HECD3_HUMAN
NC score	0.133522 (rank : 29)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	33	Target Neighborhood Hits	49	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
NC score	0.133461 (rank : 30)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	33	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

UBE3A_HUMAN
NC score	0.120431 (rank : 31)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	33	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.120229 (rank : 32)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	33	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HECD2_HUMAN
NC score	0.117605 (rank : 33)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	33	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
NC score	0.116316 (rank : 34)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	33	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

EDD1_HUMAN
NC score	0.114804 (rank : 35)	θ value	0.47712 (rank : 27)
Query Neighborhood Hits	33	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
NC score	0.111868 (rank : 36)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	33	Target Neighborhood Hits	167	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

UBE3C_HUMAN
NC score	0.101492 (rank : 37)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	33	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.101148 (rank : 38)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	33	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.100500 (rank : 39)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	33	Target Neighborhood Hits	319	Shared Neighborhood Hits	7
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HUWE1_MOUSE
NC score	0.095956 (rank : 40)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	33	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.094788 (rank : 41)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	33	Target Neighborhood Hits	443	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

SMUF2_HUMAN
NC score	0.093383 (rank : 42)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	33	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
NC score	0.093372 (rank : 43)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	33	Target Neighborhood Hits	135	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.092947 (rank : 44)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	33	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

ITCH_MOUSE
NC score	0.091591 (rank : 45)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	33	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.090856 (rank : 46)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	33	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP2_MOUSE
NC score	0.087886 (rank : 47)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	33	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP1_MOUSE
NC score	0.086761 (rank : 48)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	33	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
NC score	0.086140 (rank : 49)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	33	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
NC score	0.085773 (rank : 50)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	33	Target Neighborhood Hits	262	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

NEDD4_MOUSE
NC score	0.085487 (rank : 51)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	33	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NED4L_MOUSE
NC score	0.084830 (rank : 52)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	33	Target Neighborhood Hits	231	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.084703 (rank : 53)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	33	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
NC score	0.083774 (rank : 54)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	33	Target Neighborhood Hits	214	Shared Neighborhood Hits	6
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

K0317_MOUSE
NC score	0.082192 (rank : 55)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	33	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
NC score	0.082142 (rank : 56)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	33	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HECD1_HUMAN
NC score	0.073536 (rank : 57)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	33	Target Neighborhood Hits	371	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

BTBD8_HUMAN
NC score	0.071598 (rank : 58)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	33	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q5XKL5, Q6V9S5	Gene names	BTBD8
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 8.

BTBDC_HUMAN
NC score	0.067442 (rank : 59)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	33	Target Neighborhood Hits	248	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

LZTR1_HUMAN
NC score	0.067199 (rank : 60)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	33	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N653, Q14776	Gene names	LZTR1, TCFL2
Domain Architecture
Description	Leucine-zipper-like transcriptional regulator 1 (LZTR-1).

LZTR1_MOUSE
NC score	0.067085 (rank : 61)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	33	Target Neighborhood Hits	200	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CQ33	Gene names	Lztr1, Tcfl2
Domain Architecture
Description	Leucine-zipper-like transcriptional regulator 1 (LZTR-1).

CUL7_HUMAN
NC score	0.064084 (rank : 62)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	33	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

ABTB2_HUMAN
NC score	0.061989 (rank : 63)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	33	Target Neighborhood Hits	391	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
NC score	0.061958 (rank : 64)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	33	Target Neighborhood Hits	414	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

RHBT3_HUMAN
NC score	0.060857 (rank : 65)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	33	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	O94955, Q8IW06	Gene names	RHOBTB3, KIAA0878
Domain Architecture
Description	Rho-related BTB domain-containing protein 3.

RHBT3_MOUSE
NC score	0.060580 (rank : 66)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	33	Target Neighborhood Hits	120	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CTN4, Q80X55, Q9CVT0	Gene names	Rhobtb3, Kiaa0878
Domain Architecture
Description	Rho-related BTB domain-containing protein 3.

BTBD3_MOUSE
NC score	0.059142 (rank : 67)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	33	Target Neighborhood Hits	124	Shared Neighborhood Hits	6
SwissProt Accessions	P58545	Gene names	Btbd3
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

BTBD3_HUMAN
NC score	0.058632 (rank : 68)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	33	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2F9	Gene names	BTBD3, KIAA0952
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

BTBD2_HUMAN
NC score	0.056525 (rank : 69)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	33	Target Neighborhood Hits	161	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BX70, O60418, O75248, Q7Z5W0, Q96SX8, Q9NPS1, Q9NX81	Gene names	BTBD2
Domain Architecture
Description	BTB/POZ domain-containing protein 2.

BTBD6_MOUSE
NC score	0.052557 (rank : 70)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	33	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K2J9	Gene names	Btbd6
Domain Architecture
Description	BTB/POZ domain-containing protein 6.

BTBD6_HUMAN
NC score	0.051334 (rank : 71)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	33	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q96KE9, Q8IVQ7, Q9BR94	Gene names	BTBD6, BDPL
Domain Architecture
Description	BTB/POZ domain-containing protein 6 (Lens BTB domain protein).

PARC_MOUSE
NC score	0.051013 (rank : 72)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	33	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

ABTB1_HUMAN
NC score	0.050935 (rank : 73)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	33	Target Neighborhood Hits	325	Shared Neighborhood Hits	4
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

ABTB1_MOUSE
NC score	0.050019 (rank : 74)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	33	Target Neighborhood Hits	349	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

EPHA2_HUMAN
NC score	0.015594 (rank : 75)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	33	Target Neighborhood Hits	1021	Shared Neighborhood Hits	7
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

FKBP5_HUMAN
NC score	0.009216 (rank : 76)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	33	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	Q13451	Gene names	FKBP5, AIG6, FKBP51
Domain Architecture
Description	FK506-binding protein 5 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (51 kDa FK506-binding protein) (FKBP- 51) (54 kDa progesterone receptor-associated immunophilin) (FKBP54) (P54) (FF1 antigen) (HSP90-binding immunophilin) (Androgen-regulated protein 6).

USH2A_HUMAN
NC score	0.000817 (rank : 77)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	33	Target Neighborhood Hits	600	Shared Neighborhood Hits	3
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).