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Network neighborhood for query Sequence : CUL7_HUMAN

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CUL7_HUMAN
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CUL7_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

PARC_HUMAN
θ value	0 (rank : 2)	NC score	0.794754 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	148	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
θ value	0 (rank : 3)	NC score	0.811550 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

HERC2_HUMAN
θ value	1.5773e-20 (rank : 4)	NC score	0.329818 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD3_MOUSE
θ value	1.33526e-19 (rank : 5)	NC score	0.444189 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
θ value	5.07402e-19 (rank : 6)	NC score	0.444750 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_MOUSE
θ value	1.13037e-18 (rank : 7)	NC score	0.322131 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

CUL1_HUMAN
θ value	1.53129e-07 (rank : 8)	NC score	0.118804 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q13616, O60719, Q8IYW1	Gene names	CUL1
Domain Architecture
Description	Cullin-1 (CUL-1).

CUL1_MOUSE
θ value	1.53129e-07 (rank : 9)	NC score	0.118798 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTX6, Q9WUI7	Gene names	Cul1
Domain Architecture
Description	Cullin-1 (CUL-1).

APC10_HUMAN
θ value	9.29e-05 (rank : 10)	NC score	0.361885 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
θ value	9.29e-05 (rank : 11)	NC score	0.359401 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

SORC3_MOUSE
θ value	0.21417 (rank : 12)	NC score	0.033024 (rank : 79)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

ZEP1_HUMAN
θ value	0.21417 (rank : 13)	NC score	0.024426 (rank : 83)
Query Neighborhood Hits	41	Target Neighborhood Hits	1036	Shared Neighborhood Hits	8
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

STA13_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.022759 (rank : 84)
Query Neighborhood Hits	41	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

CRSP6_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.049292 (rank : 78)
Query Neighborhood Hits	41	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVC6, Q9UNP7, Q9Y2W0, Q9Y660	Gene names	CRSP6, ARC77, DRIP77, DRIP80, TRAP80
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 6 (Cofactor required for Sp1 transcriptional activation subunit 6) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Activator-recruited cofactor 77 kDa component) (ARC77).

IVD_MOUSE
θ value	1.81305 (rank : 16)	NC score	0.014399 (rank : 91)
Query Neighborhood Hits	41	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JHI5, Q9CYI3, Q9DBD7	Gene names	Ivd
Domain Architecture	No domain graphic available
Description	Isovaleryl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.10) (IVD).

OXA1L_MOUSE
θ value	1.81305 (rank : 17)	NC score	0.028796 (rank : 80)
Query Neighborhood Hits	41	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGA9, Q8BK01, Q8R091, Q9D8X7	Gene names	Oxa1l
Domain Architecture
Description	Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein) (OXA1-like protein).

BICD2_MOUSE
θ value	2.36792 (rank : 18)	NC score	0.006953 (rank : 103)
Query Neighborhood Hits	41	Target Neighborhood Hits	864	Shared Neighborhood Hits	2
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CCNB3_HUMAN
θ value	2.36792 (rank : 19)	NC score	0.014529 (rank : 90)
Query Neighborhood Hits	41	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

ADSV_HUMAN
θ value	3.0926 (rank : 20)	NC score	0.013586 (rank : 93)
Query Neighborhood Hits	41	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6U3, Q8NBZ6, Q8WU97, Q96JC7, Q96PY2	Gene names	SCIN, KIAA1905
Domain Architecture
Description	Adseverin (Scinderin).

GCX1_HUMAN
θ value	3.0926 (rank : 21)	NC score	0.019666 (rank : 87)
Query Neighborhood Hits	41	Target Neighborhood Hits	132	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NM4, Q5TE33, Q5TE34, Q5TE35, Q96IC9, Q9BQN5	Gene names	GCX1, C20orf100
Domain Architecture
Description	Granulosa cell HMG box protein 1 (GCX-1).

MMP16_MOUSE
θ value	3.0926 (rank : 22)	NC score	0.007027 (rank : 102)
Query Neighborhood Hits	41	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

LBN_HUMAN
θ value	4.03905 (rank : 23)	NC score	0.014018 (rank : 92)
Query Neighborhood Hits	41	Target Neighborhood Hits	308	Shared Neighborhood Hits	2
SwissProt Accessions	Q86UK5, Q86YT3, Q86YT4, Q8NG49	Gene names	EVC2, LBN
Domain Architecture	No domain graphic available
Description	Limbin.

NTNG1_HUMAN
θ value	4.03905 (rank : 24)	NC score	0.010269 (rank : 96)
Query Neighborhood Hits	41	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2I2, Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633	Gene names	NTNG1, KIAA0976, LMNT1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

NTNG1_MOUSE
θ value	4.03905 (rank : 25)	NC score	0.010262 (rank : 97)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4G0, Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8	Gene names	Ntng1, Kiaa0976, Lmnt1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

SORC2_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.025437 (rank : 81)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

TTC28_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.021849 (rank : 85)
Query Neighborhood Hits	41	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_MOUSE
θ value	4.03905 (rank : 28)	NC score	0.021794 (rank : 86)
Query Neighborhood Hits	41	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

V2RX_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.008410 (rank : 101)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70410	Gene names
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor X precursor (Putative pheromone receptor V2RX).

ADSV_MOUSE
θ value	5.27518 (rank : 30)	NC score	0.012406 (rank : 95)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q60604, O08988, O08990	Gene names	Scin
Domain Architecture
Description	Adseverin (Scinderin) (Gelsolin-like protein).

SORC2_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.024519 (rank : 82)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

CPNE1_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.005656 (rank : 104)
Query Neighborhood Hits	41	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

LRIG3_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.002737 (rank : 105)
Query Neighborhood Hits	41	Target Neighborhood Hits	611	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

MRS2L_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.015846 (rank : 89)
Query Neighborhood Hits	41	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q5NCE8	Gene names	Mrs2l, Gm902
Domain Architecture	No domain graphic available
Description	Magnesium transporter MRS2L, mitochondrial precursor (MRS2-like protein).

SNPC2_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.017149 (rank : 88)
Query Neighborhood Hits	41	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q13487, Q13486	Gene names	SNAPC2, SNAP45
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE- binding factor subunit delta) (PTF subunit delta).

ZSCA2_HUMAN
θ value	6.88961 (rank : 36)	NC score	-0.000897 (rank : 107)
Query Neighborhood Hits	41	Target Neighborhood Hits	803	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7L9, Q6ZQY9, Q9NWU4	Gene names	ZSCAN2, ZFP29
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29).

CT012_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.009658 (rank : 98)
Query Neighborhood Hits	41	Target Neighborhood Hits	205	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

LRIG3_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.002375 (rank : 106)
Query Neighborhood Hits	41	Target Neighborhood Hits	601	Shared Neighborhood Hits	3
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

MATR3_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.008450 (rank : 100)
Query Neighborhood Hits	41	Target Neighborhood Hits	321	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

TYSY_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.013383 (rank : 94)
Query Neighborhood Hits	41	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P07607	Gene names	Tyms
Domain Architecture
Description	Thymidylate synthase (EC 2.1.1.45) (TS) (TSase).

ZEP1_MOUSE
θ value	8.99809 (rank : 41)	NC score	0.009107 (rank : 99)
Query Neighborhood Hits	41	Target Neighborhood Hits	1063	Shared Neighborhood Hits	4
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

ALS2_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.050968 (rank : 75)
Query Neighborhood Hits	41	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ARI1_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.199396 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4X5, O76026, Q9H3T6, Q9UEN0, Q9UP39	Gene names	ARIH1, ARI, UBCH7BP
Domain Architecture
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6).

ARI1_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.199357 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1K5, Q6PF92	Gene names	Arih1, Ari, Ubch7bp, Uip77
Domain Architecture	No domain graphic available
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein 77).

ARI2_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.213794 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	O95376, Q9HBZ6, Q9UEM9	Gene names	ARIH2, ARI2, TRIAD1
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein).

ARI2_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.214042 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1K6	Gene names	Arih2, Ari2, Triad1, Uip48
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein) (UbcM4-interacting protein 48).

CUL2_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.055945 (rank : 67)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q13617, O00200, Q9UNF9	Gene names	CUL2
Domain Architecture
Description	Cullin-2 (CUL-2).

CUL2_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.055943 (rank : 68)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D4H8, Q3TUR8	Gene names	Cul2
Domain Architecture
Description	Cullin-2 (CUL-2).

CUL3_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.063572 (rank : 50)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

CUL3_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.063400 (rank : 52)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

CUL4A_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.088994 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q13619, O75834, Q589T6, Q5TC62, Q6UP08, Q9UP17	Gene names	CUL4A
Domain Architecture
Description	Cullin-4A (CUL-4A).

CUL4A_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.088104 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q3TCH7, Q3THM3, Q91Z44	Gene names	Cul4a
Domain Architecture	No domain graphic available
Description	Cullin-4A (CUL-4A).

CUL4B_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.090433 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

CUL5_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.050846 (rank : 76)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q93034, O14766, Q9BZC6	Gene names	CUL5, VACM1
Domain Architecture
Description	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor) (VACM-1).

CUL5_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.050676 (rank : 77)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D5V5, Q8BMQ6, Q8BV53, Q8C098	Gene names	Cul5
Domain Architecture
Description	Cullin-5 (CUL-5).

EDD1_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.070499 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	170	Shared Neighborhood Hits	6
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.070449 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD2_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.066763 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.067165 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.069278 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.070842 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.067505 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	443	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.067632 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	406	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

IBRD1_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.132256 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TC41, Q9BX48	Gene names	IBRDC1
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 1.

IBRD2_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.104082 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z419, Q6P4Q0, Q8N3R7, Q9BX38	Gene names	IBRDC2, P53RFP
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2) (p53-inducible RING finger protein).

IBRD2_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.119955 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BKD6, Q8BG97	Gene names	Ibrdc2
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2).

IBRD3_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.140014 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

ITCH_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.059119 (rank : 60)
Query Neighborhood Hits	41	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.059681 (rank : 58)
Query Neighborhood Hits	41	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

K0317_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.057944 (rank : 61)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.057538 (rank : 63)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

NEDD4_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.053380 (rank : 73)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	5
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.054169 (rank : 71)
Query Neighborhood Hits	41	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PRKN2_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.132908 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

PRKN2_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.133700 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVS6, Q9ES22, Q9ES23	Gene names	Park2, Prkn
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN).

RCC1_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.064102 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.059179 (rank : 59)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.063454 (rank : 51)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.062738 (rank : 54)
Query Neighborhood Hits	41	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RNF14_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.156278 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

RNF14_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.157785 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI90, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89	Gene names	Rnf14, Ara54, Triad2
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein).

RNF19_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.125568 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

RNF19_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.126166 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

RNF31_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.106158 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

RNF31_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.103135 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

RPGR_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.051433 (rank : 74)
Query Neighborhood Hits	41	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.054723 (rank : 69)
Query Neighborhood Hits	41	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SMUF1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.060307 (rank : 56)
Query Neighborhood Hits	41	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.060125 (rank : 57)
Query Neighborhood Hits	41	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.060861 (rank : 55)
Query Neighborhood Hits	41	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SRGEF_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.064084 (rank : 49)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.064095 (rank : 48)
Query Neighborhood Hits	41	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

TRIPC_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.074700 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	319	Shared Neighborhood Hits	5
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UB7I3_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.115896 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

UB7I3_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.118208 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

UB7I4_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.129573 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

UB7I4_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.132943 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

UBE3A_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.068867 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.063349 (rank : 53)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.071136 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.070692 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WBS16_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.053767 (rank : 72)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.054216 (rank : 70)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WWP1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.055957 (rank : 66)
Query Neighborhood Hits	41	Target Neighborhood Hits	262	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.056596 (rank : 65)
Query Neighborhood Hits	41	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.057319 (rank : 64)
Query Neighborhood Hits	41	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.057695 (rank : 62)
Query Neighborhood Hits	41	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

Hits sorted by NC score

CUL7_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

PARC_MOUSE
NC score	0.811550 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PARC_HUMAN
NC score	0.794754 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	148	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

HECD3_HUMAN
NC score	0.444750 (rank : 4)	θ value	5.07402e-19 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
NC score	0.444189 (rank : 5)	θ value	1.33526e-19 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

APC10_HUMAN
NC score	0.361885 (rank : 6)	θ value	9.29e-05 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
NC score	0.359401 (rank : 7)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

HERC2_HUMAN
NC score	0.329818 (rank : 8)	θ value	1.5773e-20 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
NC score	0.322131 (rank : 9)	θ value	1.13037e-18 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

ARI2_MOUSE
NC score	0.214042 (rank : 10)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1K6	Gene names	Arih2, Ari2, Triad1, Uip48
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein) (UbcM4-interacting protein 48).

ARI2_HUMAN
NC score	0.213794 (rank : 11)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	O95376, Q9HBZ6, Q9UEM9	Gene names	ARIH2, ARI2, TRIAD1
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein).

ARI1_HUMAN
NC score	0.199396 (rank : 12)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4X5, O76026, Q9H3T6, Q9UEN0, Q9UP39	Gene names	ARIH1, ARI, UBCH7BP
Domain Architecture
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6).

ARI1_MOUSE
NC score	0.199357 (rank : 13)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1K5, Q6PF92	Gene names	Arih1, Ari, Ubch7bp, Uip77
Domain Architecture	No domain graphic available
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein 77).

RNF14_MOUSE
NC score	0.157785 (rank : 14)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	41	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI90, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89	Gene names	Rnf14, Ara54, Triad2
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein).

RNF14_HUMAN
NC score	0.156278 (rank : 15)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	41	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

IBRD3_HUMAN
NC score	0.140014 (rank : 16)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	41	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

PRKN2_MOUSE
NC score	0.133700 (rank : 17)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	41	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVS6, Q9ES22, Q9ES23	Gene names	Park2, Prkn
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN).

UB7I4_MOUSE
NC score	0.132943 (rank : 18)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

PRKN2_HUMAN
NC score	0.132908 (rank : 19)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

IBRD1_HUMAN
NC score	0.132256 (rank : 20)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	41	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TC41, Q9BX48	Gene names	IBRDC1
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 1.

UB7I4_HUMAN
NC score	0.129573 (rank : 21)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	41	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

RNF19_MOUSE
NC score	0.126166 (rank : 22)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	41	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

RNF19_HUMAN
NC score	0.125568 (rank : 23)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	41	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

IBRD2_MOUSE
NC score	0.119955 (rank : 24)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BKD6, Q8BG97	Gene names	Ibrdc2
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2).

CUL1_HUMAN
NC score	0.118804 (rank : 25)	θ value	1.53129e-07 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q13616, O60719, Q8IYW1	Gene names	CUL1
Domain Architecture
Description	Cullin-1 (CUL-1).

CUL1_MOUSE
NC score	0.118798 (rank : 26)	θ value	1.53129e-07 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTX6, Q9WUI7	Gene names	Cul1
Domain Architecture
Description	Cullin-1 (CUL-1).

UB7I3_MOUSE
NC score	0.118208 (rank : 27)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	41	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

UB7I3_HUMAN
NC score	0.115896 (rank : 28)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	41	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

RNF31_HUMAN
NC score	0.106158 (rank : 29)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	41	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

IBRD2_HUMAN
NC score	0.104082 (rank : 30)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	41	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z419, Q6P4Q0, Q8N3R7, Q9BX38	Gene names	IBRDC2, P53RFP
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2) (p53-inducible RING finger protein).

RNF31_MOUSE
NC score	0.103135 (rank : 31)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

CUL4B_HUMAN
NC score	0.090433 (rank : 32)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	41	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

CUL4A_HUMAN
NC score	0.088994 (rank : 33)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q13619, O75834, Q589T6, Q5TC62, Q6UP08, Q9UP17	Gene names	CUL4A
Domain Architecture
Description	Cullin-4A (CUL-4A).

CUL4A_MOUSE
NC score	0.088104 (rank : 34)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q3TCH7, Q3THM3, Q91Z44	Gene names	Cul4a
Domain Architecture	No domain graphic available
Description	Cullin-4A (CUL-4A).

TRIPC_HUMAN
NC score	0.074700 (rank : 35)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	41	Target Neighborhood Hits	319	Shared Neighborhood Hits	5
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3C_HUMAN
NC score	0.071136 (rank : 36)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	41	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HERC5_HUMAN
NC score	0.070842 (rank : 37)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

UBE3C_MOUSE
NC score	0.070692 (rank : 38)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

EDD1_HUMAN
NC score	0.070499 (rank : 39)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	41	Target Neighborhood Hits	170	Shared Neighborhood Hits	6
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
NC score	0.070449 (rank : 40)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	41	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HERC3_HUMAN
NC score	0.069278 (rank : 41)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	41	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

UBE3A_HUMAN
NC score	0.068867 (rank : 42)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	41	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

HUWE1_MOUSE
NC score	0.067632 (rank : 43)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	41	Target Neighborhood Hits	406	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.067505 (rank : 44)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	41	Target Neighborhood Hits	443	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HECD2_MOUSE
NC score	0.067165 (rank : 45)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	41	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.066763 (rank : 46)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

RCC1_HUMAN
NC score	0.064102 (rank : 47)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

SRGEF_MOUSE
NC score	0.064095 (rank : 48)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	41	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_HUMAN
NC score	0.064084 (rank : 49)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

CUL3_HUMAN
NC score	0.063572 (rank : 50)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

RCC2_HUMAN
NC score	0.063454 (rank : 51)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

CUL3_MOUSE
NC score	0.063400 (rank : 52)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

UBE3A_MOUSE
NC score	0.063349 (rank : 53)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

RCC2_MOUSE
NC score	0.062738 (rank : 54)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	41	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

SMUF2_HUMAN
NC score	0.060861 (rank : 55)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	41	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
NC score	0.060307 (rank : 56)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	41	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.060125 (rank : 57)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	41	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

ITCH_MOUSE
NC score	0.059681 (rank : 58)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	41	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

RCC1_MOUSE
NC score	0.059179 (rank : 59)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

ITCH_HUMAN
NC score	0.059119 (rank : 60)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	41	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

K0317_HUMAN
NC score	0.057944 (rank : 61)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

WWP2_MOUSE
NC score	0.057695 (rank : 62)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	41	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

K0317_MOUSE
NC score	0.057538 (rank : 63)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

WWP2_HUMAN
NC score	0.057319 (rank : 64)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	41	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_MOUSE
NC score	0.056596 (rank : 65)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	41	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP1_HUMAN
NC score	0.055957 (rank : 66)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	41	Target Neighborhood Hits	262	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

CUL2_HUMAN
NC score	0.055945 (rank : 67)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q13617, O00200, Q9UNF9	Gene names	CUL2
Domain Architecture
Description	Cullin-2 (CUL-2).

CUL2_MOUSE
NC score	0.055943 (rank : 68)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D4H8, Q3TUR8	Gene names	Cul2
Domain Architecture
Description	Cullin-2 (CUL-2).

RPGR_MOUSE
NC score	0.054723 (rank : 69)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	41	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

WBS16_MOUSE
NC score	0.054216 (rank : 70)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

NEDD4_MOUSE
NC score	0.054169 (rank : 71)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	41	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

WBS16_HUMAN
NC score	0.053767 (rank : 72)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

NEDD4_HUMAN
NC score	0.053380 (rank : 73)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	5
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

RPGR_HUMAN
NC score	0.051433 (rank : 74)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	41	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

ALS2_HUMAN
NC score	0.050968 (rank : 75)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CUL5_HUMAN
NC score	0.050846 (rank : 76)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	41	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q93034, O14766, Q9BZC6	Gene names	CUL5, VACM1
Domain Architecture
Description	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor) (VACM-1).

CUL5_MOUSE
NC score	0.050676 (rank : 77)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D5V5, Q8BMQ6, Q8BV53, Q8C098	Gene names	Cul5
Domain Architecture
Description	Cullin-5 (CUL-5).

CRSP6_HUMAN
NC score	0.049292 (rank : 78)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVC6, Q9UNP7, Q9Y2W0, Q9Y660	Gene names	CRSP6, ARC77, DRIP77, DRIP80, TRAP80
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 6 (Cofactor required for Sp1 transcriptional activation subunit 6) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Activator-recruited cofactor 77 kDa component) (ARC77).

SORC3_MOUSE
NC score	0.033024 (rank : 79)	θ value	0.21417 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

OXA1L_MOUSE
NC score	0.028796 (rank : 80)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGA9, Q8BK01, Q8R091, Q9D8X7	Gene names	Oxa1l
Domain Architecture
Description	Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein) (OXA1-like protein).

SORC2_MOUSE
NC score	0.025437 (rank : 81)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_HUMAN
NC score	0.024519 (rank : 82)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

ZEP1_HUMAN
NC score	0.024426 (rank : 83)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	1036	Shared Neighborhood Hits	8
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

STA13_HUMAN
NC score	0.022759 (rank : 84)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

TTC28_HUMAN
NC score	0.021849 (rank : 85)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_MOUSE
NC score	0.021794 (rank : 86)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

GCX1_HUMAN
NC score	0.019666 (rank : 87)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	132	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NM4, Q5TE33, Q5TE34, Q5TE35, Q96IC9, Q9BQN5	Gene names	GCX1, C20orf100
Domain Architecture
Description	Granulosa cell HMG box protein 1 (GCX-1).

SNPC2_HUMAN
NC score	0.017149 (rank : 88)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q13487, Q13486	Gene names	SNAPC2, SNAP45
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE- binding factor subunit delta) (PTF subunit delta).

MRS2L_MOUSE
NC score	0.015846 (rank : 89)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q5NCE8	Gene names	Mrs2l, Gm902
Domain Architecture	No domain graphic available
Description	Magnesium transporter MRS2L, mitochondrial precursor (MRS2-like protein).

CCNB3_HUMAN
NC score	0.014529 (rank : 90)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

IVD_MOUSE
NC score	0.014399 (rank : 91)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JHI5, Q9CYI3, Q9DBD7	Gene names	Ivd
Domain Architecture	No domain graphic available
Description	Isovaleryl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.10) (IVD).

LBN_HUMAN
NC score	0.014018 (rank : 92)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	308	Shared Neighborhood Hits	2
SwissProt Accessions	Q86UK5, Q86YT3, Q86YT4, Q8NG49	Gene names	EVC2, LBN
Domain Architecture	No domain graphic available
Description	Limbin.

ADSV_HUMAN
NC score	0.013586 (rank : 93)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6U3, Q8NBZ6, Q8WU97, Q96JC7, Q96PY2	Gene names	SCIN, KIAA1905
Domain Architecture
Description	Adseverin (Scinderin).

TYSY_MOUSE
NC score	0.013383 (rank : 94)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P07607	Gene names	Tyms
Domain Architecture
Description	Thymidylate synthase (EC 2.1.1.45) (TS) (TSase).

ADSV_MOUSE
NC score	0.012406 (rank : 95)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q60604, O08988, O08990	Gene names	Scin
Domain Architecture
Description	Adseverin (Scinderin) (Gelsolin-like protein).

NTNG1_HUMAN
NC score	0.010269 (rank : 96)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2I2, Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633	Gene names	NTNG1, KIAA0976, LMNT1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

NTNG1_MOUSE
NC score	0.010262 (rank : 97)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	246	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4G0, Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8	Gene names	Ntng1, Kiaa0976, Lmnt1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

CT012_HUMAN
NC score	0.009658 (rank : 98)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	205	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

ZEP1_MOUSE
NC score	0.009107 (rank : 99)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	1063	Shared Neighborhood Hits	4
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

MATR3_MOUSE
NC score	0.008450 (rank : 100)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	321	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

V2RX_MOUSE
NC score	0.008410 (rank : 101)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70410	Gene names
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor X precursor (Putative pheromone receptor V2RX).

MMP16_MOUSE
NC score	0.007027 (rank : 102)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

BICD2_MOUSE
NC score	0.006953 (rank : 103)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	864	Shared Neighborhood Hits	2
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CPNE1_MOUSE
NC score	0.005656 (rank : 104)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

LRIG3_MOUSE
NC score	0.002737 (rank : 105)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	611	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

LRIG3_HUMAN
NC score	0.002375 (rank : 106)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	601	Shared Neighborhood Hits	3
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

ZSCA2_HUMAN
NC score	-0.000897 (rank : 107)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	803	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7L9, Q6ZQY9, Q9NWU4	Gene names	ZSCAN2, ZFP29
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29).