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Network neighborhood for query Sequence : UB7I4_MOUSE

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UB7I4_MOUSE
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UB7I4_MOUSE
θ value	7.508e-164 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

UB7I4_HUMAN
θ value	7.27209e-159 (rank : 2)	NC score	0.997668 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	54	Shared Neighborhood Hits	49
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

IBRD2_HUMAN
θ value	1.22112e-97 (rank : 3)	NC score	0.974825 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	55	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z419, Q6P4Q0, Q8N3R7, Q9BX38	Gene names	IBRDC2, P53RFP
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2) (p53-inducible RING finger protein).

IBRD2_MOUSE
θ value	2.30828e-88 (rank : 4)	NC score	0.971135 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKD6, Q8BG97	Gene names	Ibrdc2
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2).

ARI2_HUMAN
θ value	1.09232e-21 (rank : 5)	NC score	0.785389 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	O95376, Q9HBZ6, Q9UEM9	Gene names	ARIH2, ARI2, TRIAD1
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein).

IBRD3_HUMAN
θ value	1.42661e-21 (rank : 6)	NC score	0.783266 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	70	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

RNF19_HUMAN
θ value	1.86321e-21 (rank : 7)	NC score	0.744873 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

RNF19_MOUSE
θ value	1.86321e-21 (rank : 8)	NC score	0.747369 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

ARI2_MOUSE
θ value	2.43343e-21 (rank : 9)	NC score	0.783026 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	106	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z1K6	Gene names	Arih2, Ari2, Triad1, Uip48
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein) (UbcM4-interacting protein 48).

RNF14_MOUSE
θ value	7.0802e-21 (rank : 10)	NC score	0.792528 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JI90, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89	Gene names	Rnf14, Ara54, Triad2
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein).

RNF14_HUMAN
θ value	3.51386e-20 (rank : 11)	NC score	0.788767 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

ARI1_HUMAN
θ value	2.97466e-19 (rank : 12)	NC score	0.781568 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y4X5, O76026, Q9H3T6, Q9UEN0, Q9UP39	Gene names	ARIH1, ARI, UBCH7BP
Domain Architecture
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6).

ARI1_MOUSE
θ value	2.97466e-19 (rank : 13)	NC score	0.781417 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z1K5, Q6PF92	Gene names	Arih1, Ari, Ubch7bp, Uip77
Domain Architecture	No domain graphic available
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein 77).

PARC_HUMAN
θ value	2.20605e-14 (rank : 14)	NC score	0.572828 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

UB7I1_MOUSE
θ value	3.76295e-14 (rank : 15)	NC score	0.603789 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	206	Shared Neighborhood Hits	24
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

PARC_MOUSE
θ value	4.91457e-14 (rank : 16)	NC score	0.562090 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

UB7I1_HUMAN
θ value	8.38298e-14 (rank : 17)	NC score	0.603191 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

RNF31_HUMAN
θ value	4.59992e-12 (rank : 18)	NC score	0.599239 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	110	Shared Neighborhood Hits	25
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

RNF31_MOUSE
θ value	6.00763e-12 (rank : 19)	NC score	0.597024 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

IBRD1_HUMAN
θ value	7.84624e-12 (rank : 20)	NC score	0.755836 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TC41, Q9BX48	Gene names	IBRDC1
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 1.

UB7I3_HUMAN
θ value	1.133e-10 (rank : 21)	NC score	0.629195 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	136	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

UB7I3_MOUSE
θ value	1.133e-10 (rank : 22)	NC score	0.627520 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

PRKN2_MOUSE
θ value	2.21117e-06 (rank : 23)	NC score	0.552276 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVS6, Q9ES22, Q9ES23	Gene names	Park2, Prkn
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN).

PRKN2_HUMAN
θ value	4.92598e-06 (rank : 24)	NC score	0.549502 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	24
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

TRI25_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.036463 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	472	Shared Neighborhood Hits	18
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRIM9_HUMAN
θ value	0.125558 (rank : 26)	NC score	0.057707 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	294	Shared Neighborhood Hits	16
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

TRIM9_MOUSE
θ value	0.125558 (rank : 27)	NC score	0.056598 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	274	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

SC24D_HUMAN
θ value	0.47712 (rank : 28)	NC score	0.042714 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

ZFYV1_MOUSE
θ value	0.813845 (rank : 29)	NC score	0.042664 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	153	Shared Neighborhood Hits	7
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZXDB_HUMAN
θ value	0.813845 (rank : 30)	NC score	0.003584 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	753	Shared Neighborhood Hits	7
SwissProt Accessions	P98169, Q9UBB3	Gene names	ZXDB
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDB.

SC24C_HUMAN
θ value	1.06291 (rank : 31)	NC score	0.024870 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	662	Shared Neighborhood Hits	6
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

BRAP_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.031691 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	560	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

BRAP_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.036863 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	409	Shared Neighborhood Hits	8
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

SPRE3_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.038013 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

ZFYV1_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.034707 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	166	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZXDA_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.002336 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	P98168, Q9UJP7	Gene names	ZXDA
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDA.

PCGF4_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.044115 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	P35226, Q16030, Q96F37	Gene names	PCGF4, BMI1, RNF51
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1) (RING finger protein 51).

PCGF4_MOUSE
θ value	1.81305 (rank : 38)	NC score	0.044121 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	P25916	Gene names	Pcgf4, Bmi-1, Bmi1
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1).

SPRE3_MOUSE
θ value	1.81305 (rank : 39)	NC score	0.035919 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

PCGF2_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.041709 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	222	Shared Neighborhood Hits	9
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

PCGF2_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.041424 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	P23798	Gene names	Pcgf2, Mel-18, Mel18, Rnf110, Zfp144, Znf144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144).

RN152_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.080372 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	107	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N8N0	Gene names	RNF152
Domain Architecture
Description	RING finger protein 152.

RN152_MOUSE
θ value	2.36792 (rank : 43)	NC score	0.080359 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	109	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BG47	Gene names	Rnf152
Domain Architecture	No domain graphic available
Description	RING finger protein 152.

RTEL1_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.021900 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

FYV1_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.026320 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.027515 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	191	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

TRI56_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.045594 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	255	Shared Neighborhood Hits	17
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

ZN645_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.038384 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	265	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

TRIM1_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.031644 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	345	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TTC3_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.016092 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	664	Shared Neighborhood Hits	7
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

EZH2_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.011299 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.011367 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

PCSK5_MOUSE
θ value	6.88961 (rank : 53)	NC score	0.004993 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	613	Shared Neighborhood Hits	6
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

MLL4_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.018167 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	722	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MYNN_HUMAN
θ value	8.99809 (rank : 55)	NC score	-0.001121 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	826	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NPC7, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NS01, Q9UIW8	Gene names	MYNN, OSZF, ZBTB31
Domain Architecture	No domain graphic available
Description	Myoneurin (Zinc finger and BTB domain-containing protein 31).

MYNN_MOUSE
θ value	8.99809 (rank : 56)	NC score	-0.001142 (rank : 62)
Query Neighborhood Hits	59	Target Neighborhood Hits	820	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MD8, Q6P1G7, Q8BT55, Q922I4, Q9CSA0, Q9CXJ8	Gene names	Mynn
Domain Architecture	No domain graphic available
Description	Myoneurin.

PZRN4_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.006491 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	438	Shared Neighborhood Hits	12
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

UHRF1_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.013960 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	278	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

ZNHI3_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.028357 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q15649, Q8WVJ3	Gene names	ZNHIT3, TRIP3
Domain Architecture
Description	Zinc finger HIT domain-containing protein 3 (Thyroid receptor- interacting protein 3) (TRIP-3) (Thyroid hormone receptor interactor 3) (HNF-4a coactivator).

CUL7_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.132943 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

FBX43_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.052652 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	Q4G163	Gene names	FBXO43, EMI2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

FBX43_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.055329 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CDI2, Q4G0C8, Q8R0R1	Gene names	Fbxo43, Emi2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

Hits sorted by NC score

UB7I4_MOUSE
NC score	0.999962 (rank : 1)	θ value	7.508e-164 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

UB7I4_HUMAN
NC score	0.997668 (rank : 2)	θ value	7.27209e-159 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	54	Shared Neighborhood Hits	49
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

IBRD2_HUMAN
NC score	0.974825 (rank : 3)	θ value	1.22112e-97 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	55	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z419, Q6P4Q0, Q8N3R7, Q9BX38	Gene names	IBRDC2, P53RFP
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2) (p53-inducible RING finger protein).

IBRD2_MOUSE
NC score	0.971135 (rank : 4)	θ value	2.30828e-88 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKD6, Q8BG97	Gene names	Ibrdc2
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2).

RNF14_MOUSE
NC score	0.792528 (rank : 5)	θ value	7.0802e-21 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JI90, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89	Gene names	Rnf14, Ara54, Triad2
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein).

RNF14_HUMAN
NC score	0.788767 (rank : 6)	θ value	3.51386e-20 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

ARI2_HUMAN
NC score	0.785389 (rank : 7)	θ value	1.09232e-21 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	O95376, Q9HBZ6, Q9UEM9	Gene names	ARIH2, ARI2, TRIAD1
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein).

IBRD3_HUMAN
NC score	0.783266 (rank : 8)	θ value	1.42661e-21 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	70	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

ARI2_MOUSE
NC score	0.783026 (rank : 9)	θ value	2.43343e-21 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	106	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z1K6	Gene names	Arih2, Ari2, Triad1, Uip48
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein) (UbcM4-interacting protein 48).

ARI1_HUMAN
NC score	0.781568 (rank : 10)	θ value	2.97466e-19 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y4X5, O76026, Q9H3T6, Q9UEN0, Q9UP39	Gene names	ARIH1, ARI, UBCH7BP
Domain Architecture
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6).

ARI1_MOUSE
NC score	0.781417 (rank : 11)	θ value	2.97466e-19 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z1K5, Q6PF92	Gene names	Arih1, Ari, Ubch7bp, Uip77
Domain Architecture	No domain graphic available
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein 77).

IBRD1_HUMAN
NC score	0.755836 (rank : 12)	θ value	7.84624e-12 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	62	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TC41, Q9BX48	Gene names	IBRDC1
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 1.

RNF19_MOUSE
NC score	0.747369 (rank : 13)	θ value	1.86321e-21 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	96	Shared Neighborhood Hits	27
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

RNF19_HUMAN
NC score	0.744873 (rank : 14)	θ value	1.86321e-21 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

UB7I3_HUMAN
NC score	0.629195 (rank : 15)	θ value	1.133e-10 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	136	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

UB7I3_MOUSE
NC score	0.627520 (rank : 16)	θ value	1.133e-10 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

UB7I1_MOUSE
NC score	0.603789 (rank : 17)	θ value	3.76295e-14 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	206	Shared Neighborhood Hits	24
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

UB7I1_HUMAN
NC score	0.603191 (rank : 18)	θ value	8.38298e-14 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

RNF31_HUMAN
NC score	0.599239 (rank : 19)	θ value	4.59992e-12 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	110	Shared Neighborhood Hits	25
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

RNF31_MOUSE
NC score	0.597024 (rank : 20)	θ value	6.00763e-12 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

PARC_HUMAN
NC score	0.572828 (rank : 21)	θ value	2.20605e-14 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
NC score	0.562090 (rank : 22)	θ value	4.91457e-14 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PRKN2_MOUSE
NC score	0.552276 (rank : 23)	θ value	2.21117e-06 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVS6, Q9ES22, Q9ES23	Gene names	Park2, Prkn
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN).

PRKN2_HUMAN
NC score	0.549502 (rank : 24)	θ value	4.92598e-06 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	24
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

CUL7_HUMAN
NC score	0.132943 (rank : 25)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	59	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

RN152_HUMAN
NC score	0.080372 (rank : 26)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	107	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N8N0	Gene names	RNF152
Domain Architecture
Description	RING finger protein 152.

RN152_MOUSE
NC score	0.080359 (rank : 27)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	109	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BG47	Gene names	Rnf152
Domain Architecture	No domain graphic available
Description	RING finger protein 152.

TRIM9_HUMAN
NC score	0.057707 (rank : 28)	θ value	0.125558 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	294	Shared Neighborhood Hits	16
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

TRIM9_MOUSE
NC score	0.056598 (rank : 29)	θ value	0.125558 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	274	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

FBX43_MOUSE
NC score	0.055329 (rank : 30)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	59	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CDI2, Q4G0C8, Q8R0R1	Gene names	Fbxo43, Emi2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

FBX43_HUMAN
NC score	0.052652 (rank : 31)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	59	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	Q4G163	Gene names	FBXO43, EMI2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

TRI56_MOUSE
NC score	0.045594 (rank : 32)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	255	Shared Neighborhood Hits	17
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

PCGF4_MOUSE
NC score	0.044121 (rank : 33)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	P25916	Gene names	Pcgf4, Bmi-1, Bmi1
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1).

PCGF4_HUMAN
NC score	0.044115 (rank : 34)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	P35226, Q16030, Q96F37	Gene names	PCGF4, BMI1, RNF51
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1) (RING finger protein 51).

SC24D_HUMAN
NC score	0.042714 (rank : 35)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

ZFYV1_MOUSE
NC score	0.042664 (rank : 36)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	153	Shared Neighborhood Hits	7
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PCGF2_HUMAN
NC score	0.041709 (rank : 37)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	222	Shared Neighborhood Hits	9
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

PCGF2_MOUSE
NC score	0.041424 (rank : 38)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	P23798	Gene names	Pcgf2, Mel-18, Mel18, Rnf110, Zfp144, Znf144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144).

ZN645_HUMAN
NC score	0.038384 (rank : 39)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	265	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

SPRE3_HUMAN
NC score	0.038013 (rank : 40)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

BRAP_MOUSE
NC score	0.036863 (rank : 41)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	409	Shared Neighborhood Hits	8
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

TRI25_HUMAN
NC score	0.036463 (rank : 42)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	472	Shared Neighborhood Hits	18
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

SPRE3_MOUSE
NC score	0.035919 (rank : 43)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

ZFYV1_HUMAN
NC score	0.034707 (rank : 44)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	166	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

BRAP_HUMAN
NC score	0.031691 (rank : 45)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	560	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

TRIM1_HUMAN
NC score	0.031644 (rank : 46)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	345	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

ZNHI3_HUMAN
NC score	0.028357 (rank : 47)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q15649, Q8WVJ3	Gene names	ZNHIT3, TRIP3
Domain Architecture
Description	Zinc finger HIT domain-containing protein 3 (Thyroid receptor- interacting protein 3) (TRIP-3) (Thyroid hormone receptor interactor 3) (HNF-4a coactivator).

FYV1_MOUSE
NC score	0.027515 (rank : 48)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	191	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.026320 (rank : 49)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

SC24C_HUMAN
NC score	0.024870 (rank : 50)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	662	Shared Neighborhood Hits	6
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

RTEL1_HUMAN
NC score	0.021900 (rank : 51)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

MLL4_HUMAN
NC score	0.018167 (rank : 52)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	722	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

TTC3_HUMAN
NC score	0.016092 (rank : 53)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	664	Shared Neighborhood Hits	7
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

UHRF1_MOUSE
NC score	0.013960 (rank : 54)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	278	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

EZH2_MOUSE
NC score	0.011367 (rank : 55)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_HUMAN
NC score	0.011299 (rank : 56)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

PZRN4_HUMAN
NC score	0.006491 (rank : 57)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	438	Shared Neighborhood Hits	12
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PCSK5_MOUSE
NC score	0.004993 (rank : 58)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	613	Shared Neighborhood Hits	6
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

ZXDB_HUMAN
NC score	0.003584 (rank : 59)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	753	Shared Neighborhood Hits	7
SwissProt Accessions	P98169, Q9UBB3	Gene names	ZXDB
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDB.

ZXDA_HUMAN
NC score	0.002336 (rank : 60)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	750	Shared Neighborhood Hits	5
SwissProt Accessions	P98168, Q9UJP7	Gene names	ZXDA
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDA.

MYNN_HUMAN
NC score	-0.001121 (rank : 61)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	826	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NPC7, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NS01, Q9UIW8	Gene names	MYNN, OSZF, ZBTB31
Domain Architecture	No domain graphic available
Description	Myoneurin (Zinc finger and BTB domain-containing protein 31).

MYNN_MOUSE
NC score	-0.001142 (rank : 62)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	820	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MD8, Q6P1G7, Q8BT55, Q922I4, Q9CSA0, Q9CXJ8	Gene names	Mynn
Domain Architecture	No domain graphic available
Description	Myoneurin.