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Network neighborhood for query Sequence : ITCH_MOUSE

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ITCH_MOUSE
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITCH_HUMAN
θ value	0 (rank : 1)	NC score	0.991555 (rank : 3)
Query Neighborhood Hits	127	Target Neighborhood Hits	162	Shared Neighborhood Hits	112
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	127	Target Neighborhood Hits	127	Shared Neighborhood Hits	127
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	0 (rank : 3)	NC score	0.983097 (rank : 6)
Query Neighborhood Hits	127	Target Neighborhood Hits	262	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	0 (rank : 4)	NC score	0.991751 (rank : 2)
Query Neighborhood Hits	127	Target Neighborhood Hits	138	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	0 (rank : 5)	NC score	0.988890 (rank : 5)
Query Neighborhood Hits	127	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	0 (rank : 6)	NC score	0.991499 (rank : 4)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	74
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NED4L_MOUSE
θ value	3.99958e-149 (rank : 7)	NC score	0.904102 (rank : 12)
Query Neighborhood Hits	127	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
θ value	5.22361e-149 (rank : 8)	NC score	0.902987 (rank : 13)
Query Neighborhood Hits	127	Target Neighborhood Hits	238	Shared Neighborhood Hits	93
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
θ value	5.22361e-149 (rank : 9)	NC score	0.917777 (rank : 11)
Query Neighborhood Hits	127	Target Neighborhood Hits	214	Shared Neighborhood Hits	87
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	1.37783e-141 (rank : 10)	NC score	0.922135 (rank : 10)
Query Neighborhood Hits	127	Target Neighborhood Hits	212	Shared Neighborhood Hits	90
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF2_HUMAN
θ value	3.17642e-138 (rank : 11)	NC score	0.966084 (rank : 7)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	77
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
θ value	5.24793e-133 (rank : 12)	NC score	0.956797 (rank : 9)
Query Neighborhood Hits	127	Target Neighborhood Hits	135	Shared Neighborhood Hits	67
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	1.16911e-132 (rank : 13)	NC score	0.959718 (rank : 8)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

HUWE1_HUMAN
θ value	5.30912e-93 (rank : 14)	NC score	0.874064 (rank : 21)
Query Neighborhood Hits	127	Target Neighborhood Hits	443	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	5.30912e-93 (rank : 15)	NC score	0.875344 (rank : 20)
Query Neighborhood Hits	127	Target Neighborhood Hits	406	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HECD2_MOUSE
θ value	3.59435e-57 (rank : 16)	NC score	0.891606 (rank : 14)
Query Neighborhood Hits	127	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
θ value	1.51013e-55 (rank : 17)	NC score	0.888714 (rank : 15)
Query Neighborhood Hits	127	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
θ value	1.01294e-51 (rank : 18)	NC score	0.885368 (rank : 16)
Query Neighborhood Hits	127	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_HUMAN
θ value	1.32293e-51 (rank : 19)	NC score	0.883382 (rank : 18)
Query Neighborhood Hits	127	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

K0317_MOUSE
θ value	1.72781e-51 (rank : 20)	NC score	0.884901 (rank : 17)
Query Neighborhood Hits	127	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_MOUSE
θ value	1.28137e-46 (rank : 21)	NC score	0.876996 (rank : 19)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HERC3_HUMAN
θ value	2.85459e-46 (rank : 22)	NC score	0.734069 (rank : 26)
Query Neighborhood Hits	127	Target Neighborhood Hits	62	Shared Neighborhood Hits	34
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

UBE3C_HUMAN
θ value	4.2656e-42 (rank : 23)	NC score	0.864363 (rank : 22)
Query Neighborhood Hits	127	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	6.15952e-41 (rank : 24)	NC score	0.862669 (rank : 23)
Query Neighborhood Hits	127	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HERC5_HUMAN
θ value	8.32485e-38 (rank : 25)	NC score	0.737889 (rank : 25)
Query Neighborhood Hits	127	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC2_MOUSE
θ value	7.29293e-34 (rank : 26)	NC score	0.627882 (rank : 31)
Query Neighborhood Hits	127	Target Neighborhood Hits	167	Shared Neighborhood Hits	38
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

TRIPC_HUMAN
θ value	2.77131e-33 (rank : 27)	NC score	0.800211 (rank : 24)
Query Neighborhood Hits	127	Target Neighborhood Hits	319	Shared Neighborhood Hits	39
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC2_HUMAN
θ value	8.06329e-33 (rank : 28)	NC score	0.623714 (rank : 32)
Query Neighborhood Hits	127	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
θ value	6.84181e-24 (rank : 29)	NC score	0.566360 (rank : 33)
Query Neighborhood Hits	127	Target Neighborhood Hits	371	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

EDD1_HUMAN
θ value	4.58923e-20 (rank : 30)	NC score	0.669713 (rank : 30)
Query Neighborhood Hits	127	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	4.58923e-20 (rank : 31)	NC score	0.671252 (rank : 29)
Query Neighborhood Hits	127	Target Neighborhood Hits	167	Shared Neighborhood Hits	34
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD3_MOUSE
θ value	1.63225e-17 (rank : 32)	NC score	0.704317 (rank : 27)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
θ value	4.74913e-17 (rank : 33)	NC score	0.699081 (rank : 28)
Query Neighborhood Hits	127	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

WWOX_HUMAN
θ value	6.41864e-14 (rank : 34)	NC score	0.396815 (rank : 40)
Query Neighborhood Hits	127	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	6.41864e-14 (rank : 35)	NC score	0.393406 (rank : 41)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	47
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

YAP1_MOUSE
θ value	8.38298e-14 (rank : 36)	NC score	0.550944 (rank : 34)
Query Neighborhood Hits	127	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
θ value	7.84624e-12 (rank : 37)	NC score	0.529133 (rank : 35)
Query Neighborhood Hits	127	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	7.84624e-12 (rank : 38)	NC score	0.528728 (rank : 36)
Query Neighborhood Hits	127	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

MAGI1_HUMAN
θ value	1.02475e-11 (rank : 39)	NC score	0.301301 (rank : 50)
Query Neighborhood Hits	127	Target Neighborhood Hits	388	Shared Neighborhood Hits	49
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

WWC1_HUMAN
θ value	3.89403e-11 (rank : 40)	NC score	0.436310 (rank : 38)
Query Neighborhood Hits	127	Target Neighborhood Hits	290	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	3.89403e-11 (rank : 41)	NC score	0.435484 (rank : 39)
Query Neighborhood Hits	127	Target Neighborhood Hits	290	Shared Neighborhood Hits	37
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

MAGI2_HUMAN
θ value	5.08577e-11 (rank : 42)	NC score	0.307750 (rank : 49)
Query Neighborhood Hits	127	Target Neighborhood Hits	373	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	5.08577e-11 (rank : 43)	NC score	0.321712 (rank : 48)
Query Neighborhood Hits	127	Target Neighborhood Hits	370	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI1_MOUSE
θ value	2.52405e-10 (rank : 44)	NC score	0.300213 (rank : 51)
Query Neighborhood Hits	127	Target Neighborhood Hits	403	Shared Neighborhood Hits	52
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PKHA5_HUMAN
θ value	5.26297e-08 (rank : 45)	NC score	0.279594 (rank : 53)
Query Neighborhood Hits	127	Target Neighborhood Hits	455	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

WWTR1_HUMAN
θ value	3.19293e-05 (rank : 46)	NC score	0.378553 (rank : 45)
Query Neighborhood Hits	127	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	3.19293e-05 (rank : 47)	NC score	0.381258 (rank : 44)
Query Neighborhood Hits	127	Target Neighborhood Hits	54	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	5.44631e-05 (rank : 48)	NC score	0.373802 (rank : 46)
Query Neighborhood Hits	127	Target Neighborhood Hits	173	Shared Neighborhood Hits	53
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

PIN1_HUMAN
θ value	9.29e-05 (rank : 49)	NC score	0.383459 (rank : 43)
Query Neighborhood Hits	127	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	9.29e-05 (rank : 50)	NC score	0.384725 (rank : 42)
Query Neighborhood Hits	127	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

GAS7_MOUSE
θ value	0.000121331 (rank : 51)	NC score	0.259202 (rank : 55)
Query Neighborhood Hits	127	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

BAG3_HUMAN
θ value	0.000158464 (rank : 52)	NC score	0.345493 (rank : 47)
Query Neighborhood Hits	127	Target Neighborhood Hits	314	Shared Neighborhood Hits	41
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	0.000158464 (rank : 53)	NC score	0.298178 (rank : 52)
Query Neighborhood Hits	127	Target Neighborhood Hits	513	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PINL_HUMAN
θ value	0.000158464 (rank : 54)	NC score	0.444342 (rank : 37)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

RHG12_HUMAN
θ value	0.000158464 (rank : 55)	NC score	0.113142 (rank : 67)
Query Neighborhood Hits	127	Target Neighborhood Hits	190	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	0.000270298 (rank : 56)	NC score	0.125723 (rank : 63)
Query Neighborhood Hits	127	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GAS7_HUMAN
θ value	0.00102713 (rank : 57)	NC score	0.260114 (rank : 54)
Query Neighborhood Hits	127	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

APBB2_MOUSE
θ value	0.00175202 (rank : 58)	NC score	0.150578 (rank : 61)
Query Neighborhood Hits	127	Target Neighborhood Hits	88	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

PRP40_HUMAN
θ value	0.00175202 (rank : 59)	NC score	0.203782 (rank : 56)
Query Neighborhood Hits	127	Target Neighborhood Hits	442	Shared Neighborhood Hits	39
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	0.00175202 (rank : 60)	NC score	0.201484 (rank : 57)
Query Neighborhood Hits	127	Target Neighborhood Hits	447	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

APBB2_HUMAN
θ value	0.00509761 (rank : 61)	NC score	0.160470 (rank : 60)
Query Neighborhood Hits	127	Target Neighborhood Hits	96	Shared Neighborhood Hits	28
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

SETD2_HUMAN
θ value	0.00509761 (rank : 62)	NC score	0.133541 (rank : 62)
Query Neighborhood Hits	127	Target Neighborhood Hits	412	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

STXB4_HUMAN
θ value	0.00869519 (rank : 63)	NC score	0.173267 (rank : 59)
Query Neighborhood Hits	127	Target Neighborhood Hits	616	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	0.00869519 (rank : 64)	NC score	0.174091 (rank : 58)
Query Neighborhood Hits	127	Target Neighborhood Hits	629	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MBB1A_HUMAN
θ value	0.0193708 (rank : 65)	NC score	0.040126 (rank : 138)
Query Neighborhood Hits	127	Target Neighborhood Hits	665	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

BMX_HUMAN
θ value	0.0563607 (rank : 66)	NC score	0.001233 (rank : 172)
Query Neighborhood Hits	127	Target Neighborhood Hits	942	Shared Neighborhood Hits	7
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

MAGE1_HUMAN
θ value	0.0563607 (rank : 67)	NC score	0.027069 (rank : 145)
Query Neighborhood Hits	127	Target Neighborhood Hits	1389	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

G6PI_HUMAN
θ value	0.0961366 (rank : 68)	NC score	0.045300 (rank : 134)
Query Neighborhood Hits	127	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P06744, Q9BSK5, Q9UHE6	Gene names	GPI
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK) (Sperm antigen 36) (SA-36).

DGCR8_HUMAN
θ value	0.163984 (rank : 69)	NC score	0.088213 (rank : 74)
Query Neighborhood Hits	127	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DGCR8_MOUSE
θ value	0.163984 (rank : 70)	NC score	0.086312 (rank : 79)
Query Neighborhood Hits	127	Target Neighborhood Hits	70	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

COA2_HUMAN
θ value	0.365318 (rank : 71)	NC score	0.020048 (rank : 148)
Query Neighborhood Hits	127	Target Neighborhood Hits	184	Shared Neighborhood Hits	9
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

ITSN1_HUMAN
θ value	0.47712 (rank : 72)	NC score	0.040897 (rank : 136)
Query Neighborhood Hits	127	Target Neighborhood Hits	1757	Shared Neighborhood Hits	43
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.47712 (rank : 73)	NC score	0.040662 (rank : 137)
Query Neighborhood Hits	127	Target Neighborhood Hits	1669	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MYOF_HUMAN
θ value	0.47712 (rank : 74)	NC score	0.061389 (rank : 107)
Query Neighborhood Hits	127	Target Neighborhood Hits	147	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

WBP4_MOUSE
θ value	0.47712 (rank : 75)	NC score	0.117547 (rank : 64)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	30
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

DMD_MOUSE
θ value	0.62314 (rank : 76)	NC score	0.039450 (rank : 139)
Query Neighborhood Hits	127	Target Neighborhood Hits	1111	Shared Neighborhood Hits	43
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

FA62A_MOUSE
θ value	0.62314 (rank : 77)	NC score	0.108304 (rank : 68)
Query Neighborhood Hits	127	Target Neighborhood Hits	155	Shared Neighborhood Hits	28
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

LEF1_HUMAN
θ value	0.62314 (rank : 78)	NC score	0.009623 (rank : 162)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJU2, Q9HAZ0	Gene names	LEF1
Domain Architecture
Description	Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha).

MLL2_HUMAN
θ value	0.62314 (rank : 79)	NC score	0.014194 (rank : 154)
Query Neighborhood Hits	127	Target Neighborhood Hits	1788	Shared Neighborhood Hits	30
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PAF49_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.025051 (rank : 147)
Query Neighborhood Hits	127	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

RHG09_HUMAN
θ value	0.62314 (rank : 81)	NC score	0.038903 (rank : 140)
Query Neighborhood Hits	127	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

PERF_HUMAN
θ value	0.813845 (rank : 82)	NC score	0.026419 (rank : 146)
Query Neighborhood Hits	127	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

RGS12_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.017182 (rank : 151)
Query Neighborhood Hits	127	Target Neighborhood Hits	333	Shared Neighborhood Hits	9
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

DMD_HUMAN
θ value	1.06291 (rank : 84)	NC score	0.044072 (rank : 135)
Query Neighborhood Hits	127	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

TOLIP_MOUSE
θ value	1.06291 (rank : 85)	NC score	0.084209 (rank : 82)
Query Neighborhood Hits	127	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

AKA11_HUMAN
θ value	1.38821 (rank : 86)	NC score	0.016061 (rank : 152)
Query Neighborhood Hits	127	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKA4, O75124, Q9NUK7	Gene names	AKAP11, AKAP220, KIAA0629
Domain Architecture
Description	A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11) (PRKA11) (A kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220).

APBB3_HUMAN
θ value	1.38821 (rank : 87)	NC score	0.115648 (rank : 65)
Query Neighborhood Hits	127	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

DMBT1_HUMAN
θ value	1.38821 (rank : 88)	NC score	0.003365 (rank : 170)
Query Neighborhood Hits	127	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

E2AK4_HUMAN
θ value	1.38821 (rank : 89)	NC score	-0.002623 (rank : 176)
Query Neighborhood Hits	127	Target Neighborhood Hits	1012	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

RBL2_MOUSE
θ value	1.38821 (rank : 90)	NC score	0.009655 (rank : 161)
Query Neighborhood Hits	127	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q64700	Gene names	Rbl2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

APBB3_MOUSE
θ value	1.81305 (rank : 91)	NC score	0.114881 (rank : 66)
Query Neighborhood Hits	127	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

FA62A_HUMAN
θ value	1.81305 (rank : 92)	NC score	0.093021 (rank : 69)
Query Neighborhood Hits	127	Target Neighborhood Hits	168	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

G6PI_MOUSE
θ value	1.81305 (rank : 93)	NC score	0.032366 (rank : 142)
Query Neighborhood Hits	127	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P06745	Gene names	Gpi, Gpi1
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK).

PA24A_MOUSE
θ value	1.81305 (rank : 94)	NC score	0.051621 (rank : 128)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	22
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

RIMS2_HUMAN
θ value	1.81305 (rank : 95)	NC score	0.071688 (rank : 92)
Query Neighborhood Hits	127	Target Neighborhood Hits	342	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	1.81305 (rank : 96)	NC score	0.071022 (rank : 93)
Query Neighborhood Hits	127	Target Neighborhood Hits	376	Shared Neighborhood Hits	33
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

CORIN_HUMAN
θ value	2.36792 (rank : 97)	NC score	-0.001785 (rank : 175)
Query Neighborhood Hits	127	Target Neighborhood Hits	453	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

DRP2_HUMAN
θ value	2.36792 (rank : 98)	NC score	0.085390 (rank : 80)
Query Neighborhood Hits	127	Target Neighborhood Hits	186	Shared Neighborhood Hits	25
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

HXC10_HUMAN
θ value	2.36792 (rank : 99)	NC score	0.002173 (rank : 171)
Query Neighborhood Hits	127	Target Neighborhood Hits	417	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

ICAM5_MOUSE
θ value	2.36792 (rank : 100)	NC score	0.004857 (rank : 169)
Query Neighborhood Hits	127	Target Neighborhood Hits	308	Shared Neighborhood Hits	3
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

PA24A_HUMAN
θ value	2.36792 (rank : 101)	NC score	0.045548 (rank : 133)
Query Neighborhood Hits	127	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

WBP4_HUMAN
θ value	2.36792 (rank : 102)	NC score	0.055423 (rank : 115)
Query Neighborhood Hits	127	Target Neighborhood Hits	86	Shared Neighborhood Hits	16
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

NCOA6_HUMAN
θ value	3.0926 (rank : 103)	NC score	0.008232 (rank : 163)
Query Neighborhood Hits	127	Target Neighborhood Hits	1202	Shared Neighborhood Hits	20
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

UTRO_HUMAN
θ value	3.0926 (rank : 104)	NC score	0.034854 (rank : 141)
Query Neighborhood Hits	127	Target Neighborhood Hits	960	Shared Neighborhood Hits	36
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

DHSA_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.019350 (rank : 149)
Query Neighborhood Hits	127	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

ITSN2_HUMAN
θ value	4.03905 (rank : 106)	NC score	0.031919 (rank : 143)
Query Neighborhood Hits	127	Target Neighborhood Hits	1173	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	4.03905 (rank : 107)	NC score	0.030615 (rank : 144)
Query Neighborhood Hits	127	Target Neighborhood Hits	1371	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DHSA_MOUSE
θ value	5.27518 (rank : 108)	NC score	0.018118 (rank : 150)
Query Neighborhood Hits	127	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2B3, Q3UH25	Gene names	Sdha
Domain Architecture	No domain graphic available
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

IF4B_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.011326 (rank : 159)
Query Neighborhood Hits	127	Target Neighborhood Hits	417	Shared Neighborhood Hits	9
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

AATK_HUMAN
θ value	6.88961 (rank : 110)	NC score	-0.004169 (rank : 177)
Query Neighborhood Hits	127	Target Neighborhood Hits	1243	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ASPP1_MOUSE
θ value	6.88961 (rank : 111)	NC score	0.011549 (rank : 157)
Query Neighborhood Hits	127	Target Neighborhood Hits	1244	Shared Neighborhood Hits	21
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BIN1_HUMAN
θ value	6.88961 (rank : 112)	NC score	0.011394 (rank : 158)
Query Neighborhood Hits	127	Target Neighborhood Hits	335	Shared Neighborhood Hits	14
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

CMGA_HUMAN
θ value	6.88961 (rank : 113)	NC score	0.006500 (rank : 165)
Query Neighborhood Hits	127	Target Neighborhood Hits	238	Shared Neighborhood Hits	8
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

DYSF_HUMAN
θ value	6.88961 (rank : 114)	NC score	0.049162 (rank : 132)
Query Neighborhood Hits	127	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

LDB2_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.004935 (rank : 168)
Query Neighborhood Hits	127	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O43679	Gene names	LDB2, CLIM1
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 2 (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1).

WDR7_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.005887 (rank : 166)
Query Neighborhood Hits	127	Target Neighborhood Hits	244	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

ABEC4_MOUSE
θ value	8.99809 (rank : 117)	NC score	0.011816 (rank : 155)
Query Neighborhood Hits	127	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q497M3	Gene names	Apobec4
Domain Architecture	No domain graphic available
Description	Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4).

AFF1_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.007042 (rank : 164)
Query Neighborhood Hits	127	Target Neighborhood Hits	506	Shared Neighborhood Hits	13
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

CBP_HUMAN
θ value	8.99809 (rank : 119)	NC score	0.015580 (rank : 153)
Query Neighborhood Hits	127	Target Neighborhood Hits	941	Shared Neighborhood Hits	18
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

GMIP_MOUSE
θ value	8.99809 (rank : 120)	NC score	0.011768 (rank : 156)
Query Neighborhood Hits	127	Target Neighborhood Hits	202	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

IF4B_MOUSE
θ value	8.99809 (rank : 121)	NC score	0.010195 (rank : 160)
Query Neighborhood Hits	127	Target Neighborhood Hits	368	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

SEM6C_MOUSE
θ value	8.99809 (rank : 122)	NC score	0.000853 (rank : 174)
Query Neighborhood Hits	127	Target Neighborhood Hits	352	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

SEM6D_HUMAN
θ value	8.99809 (rank : 123)	NC score	0.000895 (rank : 173)
Query Neighborhood Hits	127	Target Neighborhood Hits	169	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SP100_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.005853 (rank : 167)
Query Neighborhood Hits	127	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O35892, O35897, O88392, O88395	Gene names	Sp100
Domain Architecture
Description	Nuclear autoantigen Sp-100 (Speckled 100 kDa) (Nuclear dot-associated Sp100 protein).

TOLIP_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.077660 (rank : 87)
Query Neighborhood Hits	127	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

UN13A_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.087021 (rank : 77)
Query Neighborhood Hits	127	Target Neighborhood Hits	285	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.089694 (rank : 71)
Query Neighborhood Hits	127	Target Neighborhood Hits	217	Shared Neighborhood Hits	26
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

ALS2_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.055163 (rank : 118)
Query Neighborhood Hits	127	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.053536 (rank : 120)
Query Neighborhood Hits	127	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

APBB1_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.075872 (rank : 89)
Query Neighborhood Hits	127	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.075399 (rank : 90)
Query Neighborhood Hits	127	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

CUL7_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.059681 (rank : 109)
Query Neighborhood Hits	127	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

DOC2A_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.066144 (rank : 101)
Query Neighborhood Hits	127	Target Neighborhood Hits	144	Shared Neighborhood Hits	22
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.070136 (rank : 96)
Query Neighborhood Hits	127	Target Neighborhood Hits	140	Shared Neighborhood Hits	23
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.067935 (rank : 98)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	25
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.066694 (rank : 99)
Query Neighborhood Hits	127	Target Neighborhood Hits	169	Shared Neighborhood Hits	25
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2G_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.053463 (rank : 121)
Query Neighborhood Hits	127	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

K1333_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.064765 (rank : 104)
Query Neighborhood Hits	127	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PA24B_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.050512 (rank : 130)
Query Neighborhood Hits	127	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24B_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.063693 (rank : 105)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	22
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PCLO_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.051761 (rank : 127)
Query Neighborhood Hits	127	Target Neighborhood Hits	2046	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.053408 (rank : 122)
Query Neighborhood Hits	127	Target Neighborhood Hits	2275	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RASL1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.077259 (rank : 88)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	21
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.073094 (rank : 91)
Query Neighborhood Hits	127	Target Neighborhood Hits	148	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.070191 (rank : 95)
Query Neighborhood Hits	127	Target Neighborhood Hits	161	Shared Neighborhood Hits	22
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RCBT1_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.063305 (rank : 106)
Query Neighborhood Hits	127	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.064999 (rank : 103)
Query Neighborhood Hits	127	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT2_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.070031 (rank : 97)
Query Neighborhood Hits	127	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.071004 (rank : 94)
Query Neighborhood Hits	127	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC1_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.084939 (rank : 81)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.082878 (rank : 84)
Query Neighborhood Hits	127	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.088095 (rank : 75)
Query Neighborhood Hits	127	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.087487 (rank : 76)
Query Neighborhood Hits	127	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RP3A_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.056087 (rank : 113)
Query Neighborhood Hits	127	Target Neighborhood Hits	305	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.052231 (rank : 126)
Query Neighborhood Hits	127	Target Neighborhood Hits	510	Shared Neighborhood Hits	30
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RPGR_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.086597 (rank : 78)
Query Neighborhood Hits	127	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.083075 (rank : 83)
Query Neighborhood Hits	127	Target Neighborhood Hits	281	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SRGEF_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.091591 (rank : 70)
Query Neighborhood Hits	127	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.088961 (rank : 73)
Query Neighborhood Hits	127	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SYT10_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.055317 (rank : 116)
Query Neighborhood Hits	127	Target Neighborhood Hits	134	Shared Neighborhood Hits	23
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.054098 (rank : 119)
Query Neighborhood Hits	127	Target Neighborhood Hits	133	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT1_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.056183 (rank : 111)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.056182 (rank : 112)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT2_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.052260 (rank : 125)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.052308 (rank : 124)
Query Neighborhood Hits	127	Target Neighborhood Hits	143	Shared Neighborhood Hits	24
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.057978 (rank : 110)
Query Neighborhood Hits	127	Target Neighborhood Hits	138	Shared Neighborhood Hits	23
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.052352 (rank : 123)
Query Neighborhood Hits	127	Target Neighborhood Hits	140	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT7_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.055985 (rank : 114)
Query Neighborhood Hits	127	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.055303 (rank : 117)
Query Neighborhood Hits	127	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT9_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.050260 (rank : 131)
Query Neighborhood Hits	127	Target Neighborhood Hits	144	Shared Neighborhood Hits	24
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.051475 (rank : 129)
Query Neighborhood Hits	127	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

TCRG1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.065890 (rank : 102)
Query Neighborhood Hits	127	Target Neighborhood Hits	929	Shared Neighborhood Hits	39
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.066354 (rank : 100)
Query Neighborhood Hits	127	Target Neighborhood Hits	947	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

UN13B_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.089602 (rank : 72)
Query Neighborhood Hits	127	Target Neighborhood Hits	210	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13D_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.060658 (rank : 108)
Query Neighborhood Hits	127	Target Neighborhood Hits	117	Shared Neighborhood Hits	18
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

WBS16_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.080636 (rank : 86)
Query Neighborhood Hits	127	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.082393 (rank : 85)
Query Neighborhood Hits	127	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

Hits sorted by NC score

ITCH_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	127	Target Neighborhood Hits	127	Shared Neighborhood Hits	127
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_MOUSE
NC score	0.991751 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	127	Target Neighborhood Hits	138	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_HUMAN
NC score	0.991555 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	127	Target Neighborhood Hits	162	Shared Neighborhood Hits	112
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP2_MOUSE
NC score	0.991499 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	74
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.988890 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	127	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
NC score	0.983097 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	127	Target Neighborhood Hits	262	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

SMUF2_HUMAN
NC score	0.966084 (rank : 7)	θ value	3.17642e-138 (rank : 11)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	77
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.959718 (rank : 8)	θ value	1.16911e-132 (rank : 13)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF1_HUMAN
NC score	0.956797 (rank : 9)	θ value	5.24793e-133 (rank : 12)
Query Neighborhood Hits	127	Target Neighborhood Hits	135	Shared Neighborhood Hits	67
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

NEDD4_MOUSE
NC score	0.922135 (rank : 10)	θ value	1.37783e-141 (rank : 10)
Query Neighborhood Hits	127	Target Neighborhood Hits	212	Shared Neighborhood Hits	90
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NEDD4_HUMAN
NC score	0.917777 (rank : 11)	θ value	5.22361e-149 (rank : 9)
Query Neighborhood Hits	127	Target Neighborhood Hits	214	Shared Neighborhood Hits	87
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.904102 (rank : 12)	θ value	3.99958e-149 (rank : 7)
Query Neighborhood Hits	127	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.902987 (rank : 13)	θ value	5.22361e-149 (rank : 8)
Query Neighborhood Hits	127	Target Neighborhood Hits	238	Shared Neighborhood Hits	93
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

HECD2_MOUSE
NC score	0.891606 (rank : 14)	θ value	3.59435e-57 (rank : 16)
Query Neighborhood Hits	127	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.888714 (rank : 15)	θ value	1.51013e-55 (rank : 17)
Query Neighborhood Hits	127	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
NC score	0.885368 (rank : 16)	θ value	1.01294e-51 (rank : 18)
Query Neighborhood Hits	127	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.884901 (rank : 17)	θ value	1.72781e-51 (rank : 20)
Query Neighborhood Hits	127	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_HUMAN
NC score	0.883382 (rank : 18)	θ value	1.32293e-51 (rank : 19)
Query Neighborhood Hits	127	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.876996 (rank : 19)	θ value	1.28137e-46 (rank : 21)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HUWE1_MOUSE
NC score	0.875344 (rank : 20)	θ value	5.30912e-93 (rank : 15)
Query Neighborhood Hits	127	Target Neighborhood Hits	406	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.874064 (rank : 21)	θ value	5.30912e-93 (rank : 14)
Query Neighborhood Hits	127	Target Neighborhood Hits	443	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

UBE3C_HUMAN
NC score	0.864363 (rank : 22)	θ value	4.2656e-42 (rank : 23)
Query Neighborhood Hits	127	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.862669 (rank : 23)	θ value	6.15952e-41 (rank : 24)
Query Neighborhood Hits	127	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.800211 (rank : 24)	θ value	2.77131e-33 (rank : 27)
Query Neighborhood Hits	127	Target Neighborhood Hits	319	Shared Neighborhood Hits	39
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
NC score	0.737889 (rank : 25)	θ value	8.32485e-38 (rank : 25)
Query Neighborhood Hits	127	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.734069 (rank : 26)	θ value	2.85459e-46 (rank : 22)
Query Neighborhood Hits	127	Target Neighborhood Hits	62	Shared Neighborhood Hits	34
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD3_MOUSE
NC score	0.704317 (rank : 27)	θ value	1.63225e-17 (rank : 32)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.699081 (rank : 28)	θ value	4.74913e-17 (rank : 33)
Query Neighborhood Hits	127	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.671252 (rank : 29)	θ value	4.58923e-20 (rank : 31)
Query Neighborhood Hits	127	Target Neighborhood Hits	167	Shared Neighborhood Hits	34
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.669713 (rank : 30)	θ value	4.58923e-20 (rank : 30)
Query Neighborhood Hits	127	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HERC2_MOUSE
NC score	0.627882 (rank : 31)	θ value	7.29293e-34 (rank : 26)
Query Neighborhood Hits	127	Target Neighborhood Hits	167	Shared Neighborhood Hits	38
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.623714 (rank : 32)	θ value	8.06329e-33 (rank : 28)
Query Neighborhood Hits	127	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.566360 (rank : 33)	θ value	6.84181e-24 (rank : 29)
Query Neighborhood Hits	127	Target Neighborhood Hits	371	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

YAP1_MOUSE
NC score	0.550944 (rank : 34)	θ value	8.38298e-14 (rank : 36)
Query Neighborhood Hits	127	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
NC score	0.529133 (rank : 35)	θ value	7.84624e-12 (rank : 37)
Query Neighborhood Hits	127	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.528728 (rank : 36)	θ value	7.84624e-12 (rank : 38)
Query Neighborhood Hits	127	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

PINL_HUMAN
NC score	0.444342 (rank : 37)	θ value	0.000158464 (rank : 54)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWC1_HUMAN
NC score	0.436310 (rank : 38)	θ value	3.89403e-11 (rank : 40)
Query Neighborhood Hits	127	Target Neighborhood Hits	290	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.435484 (rank : 39)	θ value	3.89403e-11 (rank : 41)
Query Neighborhood Hits	127	Target Neighborhood Hits	290	Shared Neighborhood Hits	37
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
NC score	0.396815 (rank : 40)	θ value	6.41864e-14 (rank : 34)
Query Neighborhood Hits	127	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.393406 (rank : 41)	θ value	6.41864e-14 (rank : 35)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	47
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

PIN1_MOUSE
NC score	0.384725 (rank : 42)	θ value	9.29e-05 (rank : 50)
Query Neighborhood Hits	127	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_HUMAN
NC score	0.383459 (rank : 43)	θ value	9.29e-05 (rank : 49)
Query Neighborhood Hits	127	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWTR1_MOUSE
NC score	0.381258 (rank : 44)	θ value	3.19293e-05 (rank : 47)
Query Neighborhood Hits	127	Target Neighborhood Hits	54	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.378553 (rank : 45)	θ value	3.19293e-05 (rank : 46)
Query Neighborhood Hits	127	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.373802 (rank : 46)	θ value	5.44631e-05 (rank : 48)
Query Neighborhood Hits	127	Target Neighborhood Hits	173	Shared Neighborhood Hits	53
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_HUMAN
NC score	0.345493 (rank : 47)	θ value	0.000158464 (rank : 52)
Query Neighborhood Hits	127	Target Neighborhood Hits	314	Shared Neighborhood Hits	41
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

MAGI2_MOUSE
NC score	0.321712 (rank : 48)	θ value	5.08577e-11 (rank : 43)
Query Neighborhood Hits	127	Target Neighborhood Hits	370	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.307750 (rank : 49)	θ value	5.08577e-11 (rank : 42)
Query Neighborhood Hits	127	Target Neighborhood Hits	373	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI1_HUMAN
NC score	0.301301 (rank : 50)	θ value	1.02475e-11 (rank : 39)
Query Neighborhood Hits	127	Target Neighborhood Hits	388	Shared Neighborhood Hits	49
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.300213 (rank : 51)	θ value	2.52405e-10 (rank : 44)
Query Neighborhood Hits	127	Target Neighborhood Hits	403	Shared Neighborhood Hits	52
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

BAG3_MOUSE
NC score	0.298178 (rank : 52)	θ value	0.000158464 (rank : 53)
Query Neighborhood Hits	127	Target Neighborhood Hits	513	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PKHA5_HUMAN
NC score	0.279594 (rank : 53)	θ value	5.26297e-08 (rank : 45)
Query Neighborhood Hits	127	Target Neighborhood Hits	455	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAS7_HUMAN
NC score	0.260114 (rank : 54)	θ value	0.00102713 (rank : 57)
Query Neighborhood Hits	127	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.259202 (rank : 55)	θ value	0.000121331 (rank : 51)
Query Neighborhood Hits	127	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PRP40_HUMAN
NC score	0.203782 (rank : 56)	θ value	0.00175202 (rank : 59)
Query Neighborhood Hits	127	Target Neighborhood Hits	442	Shared Neighborhood Hits	39
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.201484 (rank : 57)	θ value	0.00175202 (rank : 60)
Query Neighborhood Hits	127	Target Neighborhood Hits	447	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

STXB4_MOUSE
NC score	0.174091 (rank : 58)	θ value	0.00869519 (rank : 64)
Query Neighborhood Hits	127	Target Neighborhood Hits	629	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.173267 (rank : 59)	θ value	0.00869519 (rank : 63)
Query Neighborhood Hits	127	Target Neighborhood Hits	616	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBB2_HUMAN
NC score	0.160470 (rank : 60)	θ value	0.00509761 (rank : 61)
Query Neighborhood Hits	127	Target Neighborhood Hits	96	Shared Neighborhood Hits	28
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
NC score	0.150578 (rank : 61)	θ value	0.00175202 (rank : 58)
Query Neighborhood Hits	127	Target Neighborhood Hits	88	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

SETD2_HUMAN
NC score	0.133541 (rank : 62)	θ value	0.00509761 (rank : 62)
Query Neighborhood Hits	127	Target Neighborhood Hits	412	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

RHG12_MOUSE
NC score	0.125723 (rank : 63)	θ value	0.000270298 (rank : 56)
Query Neighborhood Hits	127	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

WBP4_MOUSE
NC score	0.117547 (rank : 64)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	30
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

APBB3_HUMAN
NC score	0.115648 (rank : 65)	θ value	1.38821 (rank : 87)
Query Neighborhood Hits	127	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
NC score	0.114881 (rank : 66)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	127	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

RHG12_HUMAN
NC score	0.113142 (rank : 67)	θ value	0.000158464 (rank : 55)
Query Neighborhood Hits	127	Target Neighborhood Hits	190	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

FA62A_MOUSE
NC score	0.108304 (rank : 68)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	127	Target Neighborhood Hits	155	Shared Neighborhood Hits	28
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.093021 (rank : 69)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	127	Target Neighborhood Hits	168	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SRGEF_HUMAN
NC score	0.091591 (rank : 70)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	127	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

UN13B_HUMAN
NC score	0.089694 (rank : 71)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	127	Target Neighborhood Hits	217	Shared Neighborhood Hits	26
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
NC score	0.089602 (rank : 72)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	127	Target Neighborhood Hits	210	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SRGEF_MOUSE
NC score	0.088961 (rank : 73)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	127	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

DGCR8_HUMAN
NC score	0.088213 (rank : 74)	θ value	0.163984 (rank : 69)
Query Neighborhood Hits	127	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

RCC2_HUMAN
NC score	0.088095 (rank : 75)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	127	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
NC score	0.087487 (rank : 76)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	127	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

UN13A_HUMAN
NC score	0.087021 (rank : 77)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	127	Target Neighborhood Hits	285	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

RPGR_HUMAN
NC score	0.086597 (rank : 78)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	127	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

DGCR8_MOUSE
NC score	0.086312 (rank : 79)	θ value	0.163984 (rank : 70)
Query Neighborhood Hits	127	Target Neighborhood Hits	70	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

DRP2_HUMAN
NC score	0.085390 (rank : 80)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	127	Target Neighborhood Hits	186	Shared Neighborhood Hits	25
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

RCC1_HUMAN
NC score	0.084939 (rank : 81)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	127	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

TOLIP_MOUSE
NC score	0.084209 (rank : 82)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	127	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

RPGR_MOUSE
NC score	0.083075 (rank : 83)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	127	Target Neighborhood Hits	281	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RCC1_MOUSE
NC score	0.082878 (rank : 84)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	127	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

WBS16_MOUSE
NC score	0.082393 (rank : 85)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	127	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WBS16_HUMAN
NC score	0.080636 (rank : 86)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	127	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

TOLIP_HUMAN
NC score	0.077660 (rank : 87)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	127	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

RASL1_HUMAN
NC score	0.077259 (rank : 88)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	21
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

APBB1_HUMAN
NC score	0.075872 (rank : 89)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	127	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.075399 (rank : 90)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	127	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

RASL1_MOUSE
NC score	0.073094 (rank : 91)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	127	Target Neighborhood Hits	148	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RIMS2_HUMAN
NC score	0.071688 (rank : 92)	θ value	1.81305 (rank : 95)
Query Neighborhood Hits	127	Target Neighborhood Hits	342	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.071022 (rank : 93)	θ value	1.81305 (rank : 96)
Query Neighborhood Hits	127	Target Neighborhood Hits	376	Shared Neighborhood Hits	33
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RCBT2_MOUSE
NC score	0.071004 (rank : 94)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	127	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RASL2_HUMAN
NC score	0.070191 (rank : 95)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	127	Target Neighborhood Hits	161	Shared Neighborhood Hits	22
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

DOC2A_MOUSE
NC score	0.070136 (rank : 96)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	127	Target Neighborhood Hits	140	Shared Neighborhood Hits	23
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

RCBT2_HUMAN
NC score	0.070031 (rank : 97)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	127	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

DOC2B_HUMAN
NC score	0.067935 (rank : 98)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	25
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
NC score	0.066694 (rank : 99)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	127	Target Neighborhood Hits	169	Shared Neighborhood Hits	25
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

TCRG1_MOUSE
NC score	0.066354 (rank : 100)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	127	Target Neighborhood Hits	947	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

DOC2A_HUMAN
NC score	0.066144 (rank : 101)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	127	Target Neighborhood Hits	144	Shared Neighborhood Hits	22
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

TCRG1_HUMAN
NC score	0.065890 (rank : 102)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	127	Target Neighborhood Hits	929	Shared Neighborhood Hits	39
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

RCBT1_MOUSE
NC score	0.064999 (rank : 103)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	127	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

K1333_MOUSE
NC score	0.064765 (rank : 104)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	127	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PA24B_MOUSE
NC score	0.063693 (rank : 105)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	22
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RCBT1_HUMAN
NC score	0.063305 (rank : 106)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	127	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

MYOF_HUMAN
NC score	0.061389 (rank : 107)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	127	Target Neighborhood Hits	147	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

UN13D_HUMAN
NC score	0.060658 (rank : 108)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	127	Target Neighborhood Hits	117	Shared Neighborhood Hits	18
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

CUL7_HUMAN
NC score	0.059681 (rank : 109)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	127	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

SYT5_HUMAN
NC score	0.057978 (rank : 110)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	127	Target Neighborhood Hits	138	Shared Neighborhood Hits	23
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT1_HUMAN
NC score	0.056183 (rank : 111)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.056182 (rank : 112)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

RP3A_HUMAN
NC score	0.056087 (rank : 113)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	127	Target Neighborhood Hits	305	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT7_HUMAN
NC score	0.055985 (rank : 114)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	127	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

WBP4_HUMAN
NC score	0.055423 (rank : 115)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	127	Target Neighborhood Hits	86	Shared Neighborhood Hits	16
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

SYT10_HUMAN
NC score	0.055317 (rank : 116)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	127	Target Neighborhood Hits	134	Shared Neighborhood Hits	23
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT7_MOUSE
NC score	0.055303 (rank : 117)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	127	Target Neighborhood Hits	137	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

ALS2_HUMAN
NC score	0.055163 (rank : 118)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	127	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SYT10_MOUSE
NC score	0.054098 (rank : 119)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	127	Target Neighborhood Hits	133	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

ALS2_MOUSE
NC score	0.053536 (rank : 120)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	127	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

DOC2G_MOUSE
NC score	0.053463 (rank : 121)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	127	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

PCLO_MOUSE
NC score	0.053408 (rank : 122)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	127	Target Neighborhood Hits	2275	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYT5_MOUSE
NC score	0.052352 (rank : 123)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	127	Target Neighborhood Hits	140	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT2_MOUSE
NC score	0.052308 (rank : 124)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	127	Target Neighborhood Hits	143	Shared Neighborhood Hits	24
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.052260 (rank : 125)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	127	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

RP3A_MOUSE
NC score	0.052231 (rank : 126)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	127	Target Neighborhood Hits	510	Shared Neighborhood Hits	30
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

PCLO_HUMAN
NC score	0.051761 (rank : 127)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	127	Target Neighborhood Hits	2046	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PA24A_MOUSE
NC score	0.051621 (rank : 128)	θ value	1.81305 (rank : 94)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	22
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

SYT9_MOUSE
NC score	0.051475 (rank : 129)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	127	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

PA24B_HUMAN
NC score	0.050512 (rank : 130)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	127	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

SYT9_HUMAN
NC score	0.050260 (rank : 131)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	127	Target Neighborhood Hits	144	Shared Neighborhood Hits	24
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

DYSF_HUMAN
NC score	0.049162 (rank : 132)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	127	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

PA24A_HUMAN
NC score	0.045548 (rank : 133)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	127	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

G6PI_HUMAN
NC score	0.045300 (rank : 134)	θ value	0.0961366 (rank : 68)
Query Neighborhood Hits	127	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P06744, Q9BSK5, Q9UHE6	Gene names	GPI
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK) (Sperm antigen 36) (SA-36).

DMD_HUMAN
NC score	0.044072 (rank : 135)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	127	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

ITSN1_HUMAN
NC score	0.040897 (rank : 136)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	127	Target Neighborhood Hits	1757	Shared Neighborhood Hits	43
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.040662 (rank : 137)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	127	Target Neighborhood Hits	1669	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MBB1A_HUMAN
NC score	0.040126 (rank : 138)	θ value	0.0193708 (rank : 65)
Query Neighborhood Hits	127	Target Neighborhood Hits	665	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

DMD_MOUSE
NC score	0.039450 (rank : 139)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	127	Target Neighborhood Hits	1111	Shared Neighborhood Hits	43
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

RHG09_HUMAN
NC score	0.038903 (rank : 140)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	127	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

UTRO_HUMAN
NC score	0.034854 (rank : 141)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	127	Target Neighborhood Hits	960	Shared Neighborhood Hits	36
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

G6PI_MOUSE
NC score	0.032366 (rank : 142)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	127	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P06745	Gene names	Gpi, Gpi1
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK).

ITSN2_HUMAN
NC score	0.031919 (rank : 143)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	127	Target Neighborhood Hits	1173	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
NC score	0.030615 (rank : 144)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	127	Target Neighborhood Hits	1371	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MAGE1_HUMAN
NC score	0.027069 (rank : 145)	θ value	0.0563607 (rank : 67)
Query Neighborhood Hits	127	Target Neighborhood Hits	1389	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PERF_HUMAN
NC score	0.026419 (rank : 146)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	127	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

PAF49_HUMAN
NC score	0.025051 (rank : 147)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	127	Target Neighborhood Hits	169	Shared Neighborhood Hits	11
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

COA2_HUMAN
NC score	0.020048 (rank : 148)	θ value	0.365318 (rank : 71)
Query Neighborhood Hits	127	Target Neighborhood Hits	184	Shared Neighborhood Hits	9
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

DHSA_HUMAN
NC score	0.019350 (rank : 149)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	127	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

DHSA_MOUSE
NC score	0.018118 (rank : 150)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	127	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2B3, Q3UH25	Gene names	Sdha
Domain Architecture	No domain graphic available
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

RGS12_HUMAN
NC score	0.017182 (rank : 151)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	127	Target Neighborhood Hits	333	Shared Neighborhood Hits	9
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

AKA11_HUMAN
NC score	0.016061 (rank : 152)	θ value	1.38821 (rank : 86)
Query Neighborhood Hits	127	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKA4, O75124, Q9NUK7	Gene names	AKAP11, AKAP220, KIAA0629
Domain Architecture
Description	A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11) (PRKA11) (A kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220).

CBP_HUMAN
NC score	0.015580 (rank : 153)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	127	Target Neighborhood Hits	941	Shared Neighborhood Hits	18
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

MLL2_HUMAN
NC score	0.014194 (rank : 154)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	127	Target Neighborhood Hits	1788	Shared Neighborhood Hits	30
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ABEC4_MOUSE
NC score	0.011816 (rank : 155)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	127	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q497M3	Gene names	Apobec4
Domain Architecture	No domain graphic available
Description	Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4).

GMIP_MOUSE
NC score	0.011768 (rank : 156)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	127	Target Neighborhood Hits	202	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

ASPP1_MOUSE
NC score	0.011549 (rank : 157)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	127	Target Neighborhood Hits	1244	Shared Neighborhood Hits	21
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BIN1_HUMAN
NC score	0.011394 (rank : 158)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	127	Target Neighborhood Hits	335	Shared Neighborhood Hits	14
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

IF4B_HUMAN
NC score	0.011326 (rank : 159)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	127	Target Neighborhood Hits	417	Shared Neighborhood Hits	9
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

IF4B_MOUSE
NC score	0.010195 (rank : 160)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	127	Target Neighborhood Hits	368	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

RBL2_MOUSE
NC score	0.009655 (rank : 161)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	127	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q64700	Gene names	Rbl2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

LEF1_HUMAN
NC score	0.009623 (rank : 162)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	127	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJU2, Q9HAZ0	Gene names	LEF1
Domain Architecture
Description	Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha).

NCOA6_HUMAN
NC score	0.008232 (rank : 163)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	127	Target Neighborhood Hits	1202	Shared Neighborhood Hits	20
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

AFF1_HUMAN
NC score	0.007042 (rank : 164)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	127	Target Neighborhood Hits	506	Shared Neighborhood Hits	13
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

CMGA_HUMAN
NC score	0.006500 (rank : 165)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	127	Target Neighborhood Hits	238	Shared Neighborhood Hits	8
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

WDR7_HUMAN
NC score	0.005887 (rank : 166)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	127	Target Neighborhood Hits	244	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

SP100_MOUSE
NC score	0.005853 (rank : 167)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	127	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O35892, O35897, O88392, O88395	Gene names	Sp100
Domain Architecture
Description	Nuclear autoantigen Sp-100 (Speckled 100 kDa) (Nuclear dot-associated Sp100 protein).

LDB2_HUMAN
NC score	0.004935 (rank : 168)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	127	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O43679	Gene names	LDB2, CLIM1
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 2 (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1).

ICAM5_MOUSE
NC score	0.004857 (rank : 169)	θ value	2.36792 (rank : 100)
Query Neighborhood Hits	127	Target Neighborhood Hits	308	Shared Neighborhood Hits	3
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

DMBT1_HUMAN
NC score	0.003365 (rank : 170)	θ value	1.38821 (rank : 88)
Query Neighborhood Hits	127	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

HXC10_HUMAN
NC score	0.002173 (rank : 171)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	127	Target Neighborhood Hits	417	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

BMX_HUMAN
NC score	0.001233 (rank : 172)	θ value	0.0563607 (rank : 66)
Query Neighborhood Hits	127	Target Neighborhood Hits	942	Shared Neighborhood Hits	7
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SEM6D_HUMAN
NC score	0.000895 (rank : 173)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	127	Target Neighborhood Hits	169	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SEM6C_MOUSE
NC score	0.000853 (rank : 174)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	127	Target Neighborhood Hits	352	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

CORIN_HUMAN
NC score	-0.001785 (rank : 175)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	127	Target Neighborhood Hits	453	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

E2AK4_HUMAN
NC score	-0.002623 (rank : 176)	θ value	1.38821 (rank : 89)
Query Neighborhood Hits	127	Target Neighborhood Hits	1012	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

AATK_HUMAN
NC score	-0.004169 (rank : 177)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	127	Target Neighborhood Hits	1243	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).