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Network neighborhood for query Sequence : DGCR8_MOUSE

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DGCR8_MOUSE
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DGCR8_HUMAN
θ value	0 (rank : 1)	NC score	0.990863 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DGCR8_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

PRKRA_HUMAN
θ value	0.00134147 (rank : 3)	NC score	0.179055 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	O75569, Q53G24, Q6X7T5, Q8NDK4	Gene names	PRKRA, PACT, RAX
Domain Architecture	No domain graphic available
Description	Interferon-inducible double stranded RNA-dependent protein kinase activator A (Protein kinase, interferon-inducible double stranded RNA- dependent activator) (Protein activator of the interferon-induced protein kinase) (PKR-associated protein X) (PKR-associating protein X).

PRKRA_MOUSE
θ value	0.00134147 (rank : 4)	NC score	0.178737 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTX2, Q9CZB7	Gene names	Prkra, Rax
Domain Architecture	No domain graphic available
Description	Interferon-inducible double stranded RNA-dependent protein kinase activator A (Protein kinase, interferon-inducible double stranded RNA- dependent activator) (Protein activator of the interferon-induced protein kinase) (PKR-associated protein X) (PKR-associating protein X) (RAX).

LRRF1_HUMAN
θ value	0.00509761 (rank : 5)	NC score	0.104205 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	625	Shared Neighborhood Hits	15
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

DSRAD_HUMAN
θ value	0.0431538 (rank : 6)	NC score	0.091339 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P55265, O15223, O43859, O43860, Q9BYM3, Q9BYM4	Gene names	ADAR, ADAR1, DSRAD, IFI4
Domain Architecture
Description	Double-stranded RNA-specific adenosine deaminase (EC 3.5.4.-) (DRADA) (136 kDa double-stranded RNA-binding protein) (P136) (K88DSRBP) (Interferon-inducible protein 4) (IFI-4 protein).

AN32A_MOUSE
θ value	0.0563607 (rank : 7)	NC score	0.105671 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	O35381, P97437	Gene names	Anp32a, Anp32, Lanp
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein).

AN32C_MOUSE
θ value	0.0563607 (rank : 8)	NC score	0.105671 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	Q64G17	Gene names	Anp32c
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C.

WWP1_MOUSE
θ value	0.0563607 (rank : 9)	NC score	0.091070 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	138	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

AN32B_HUMAN
θ value	0.125558 (rank : 10)	NC score	0.099496 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	243	Shared Neighborhood Hits	7
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

ITCH_HUMAN
θ value	0.163984 (rank : 11)	NC score	0.085669 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	162	Shared Neighborhood Hits	15
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	0.163984 (rank : 12)	NC score	0.086312 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	127	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	0.21417 (rank : 13)	NC score	0.085482 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	262	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

NED4L_HUMAN
θ value	0.365318 (rank : 14)	NC score	0.076396 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	238	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

HTSF1_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.074142 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	408	Shared Neighborhood Hits	10
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

WWTR1_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.109499 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	0.47712 (rank : 17)	NC score	0.110836 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	54	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

HTSF1_MOUSE
θ value	0.62314 (rank : 18)	NC score	0.070776 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	425	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

CD2L1_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.007907 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	1467	Shared Neighborhood Hits	12
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

AN32A_HUMAN
θ value	1.06291 (rank : 20)	NC score	0.081346 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	234	Shared Neighborhood Hits	7
SwissProt Accessions	P39687	Gene names	ANP32A, C15orf1, LANP, MAPM, PHAP1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp) (Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin).

C2TA_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.041627 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

GGN_HUMAN
θ value	1.06291 (rank : 22)	NC score	0.035360 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

LRRF1_MOUSE
θ value	1.06291 (rank : 23)	NC score	0.073574 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	440	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

MAP2_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.041182 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	348	Shared Neighborhood Hits	9
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

NED4L_MOUSE
θ value	1.06291 (rank : 25)	NC score	0.070312 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

CABL1_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.047129 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN4, Q8N3Y8, Q8NA22, Q9BTG1	Gene names	CABLES1, CABLES
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

NEDD4_MOUSE
θ value	1.81305 (rank : 27)	NC score	0.068532 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	212	Shared Neighborhood Hits	14
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

AMPM2_MOUSE
θ value	2.36792 (rank : 28)	NC score	0.029603 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O08663	Gene names	Metap2, Mnpep, P67eif2
Domain Architecture
Description	Methionine aminopeptidase 2 (EC 3.4.11.18) (MetAP 2) (Peptidase M 2) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2).

LMO7_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.037959 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	507	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MAP2_MOUSE
θ value	2.36792 (rank : 30)	NC score	0.039944 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	342	Shared Neighborhood Hits	11
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

MLL4_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.016740 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	722	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

WNK1_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.008429 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	1179	Shared Neighborhood Hits	10
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CN145_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.008580 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	1196	Shared Neighborhood Hits	12
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CSKI1_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.014364 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	1031	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NEB2_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.017062 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	883	Shared Neighborhood Hits	17
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SFPQ_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.013965 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	958	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

YAP1_MOUSE
θ value	3.0926 (rank : 37)	NC score	0.090064 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	96	Shared Neighborhood Hits	14
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

DNJBA_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.012630 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QYI5	Gene names	Dnajb10
Domain Architecture
Description	DnaJ homolog subfamily B member 10 (mDJ8).

HS90A_MOUSE
θ value	4.03905 (rank : 39)	NC score	0.020517 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	155	Shared Neighborhood Hits	3
SwissProt Accessions	P07901	Gene names	Hsp90aa1, Hsp86, Hsp86-1, Hspca
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (Tumor-specific transplantation 86 kDa antigen) (TSTA).

KIF3A_MOUSE
θ value	4.03905 (rank : 40)	NC score	0.006142 (rank : 77)
Query Neighborhood Hits	70	Target Neighborhood Hits	715	Shared Neighborhood Hits	8
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

NCOR2_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.024221 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	870	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NFAT5_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.015876 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

UBQL4_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.020777 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRR5, Q9BR98, Q9UHX4	Gene names	UBQLN4, C1orf6, UBIN
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

UBQL4_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.021034 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

ZN710_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.002825 (rank : 79)
Query Neighborhood Hits	70	Target Neighborhood Hits	796	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N1W2, Q6ZMK9, Q8NDU0	Gene names	ZNF710
Domain Architecture	No domain graphic available
Description	Zinc finger protein 710.

CN155_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.029856 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	385	Shared Neighborhood Hits	8
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

GP101_MOUSE
θ value	5.27518 (rank : 47)	NC score	0.006727 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	916	Shared Neighborhood Hits	6
SwissProt Accessions	Q80T62, Q3UUI9	Gene names	Gpr101
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 101.

IRX5_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.010888 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JKQ4, Q80WV4, Q9JLL5	Gene names	Irx5, Irxb2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2).

MAGI2_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.037835 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	370	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MPP10_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.017531 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	306	Shared Neighborhood Hits	6
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

NCOR2_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.022609 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	790	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

ZO1_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.010451 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	453	Shared Neighborhood Hits	7
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

AN32B_MOUSE
θ value	6.88961 (rank : 53)	NC score	0.066852 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	236	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

CKAP5_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.021881 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q14008, Q14668	Gene names	CKAP5, KIAA0097
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor over- expressed protein) (Ch-TOG protein).

PAF49_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.030871 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	169	Shared Neighborhood Hits	6
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

SRC8_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.018691 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	269	Shared Neighborhood Hits	6
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.018206 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

YAP1_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.075305 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	173	Shared Neighborhood Hits	14
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ZN710_MOUSE
θ value	6.88961 (rank : 59)	NC score	0.002030 (rank : 80)
Query Neighborhood Hits	70	Target Neighborhood Hits	749	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U288, Q3U341, Q6P9R3, Q8BJH0, Q8BTL6	Gene names	Znf710, Zfp710
Domain Architecture	No domain graphic available
Description	Zinc finger protein 710.

CSKI1_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.007891 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	997	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CYLD_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.012957 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

DC1L1_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.010764 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6G9, Q53HC8, Q53HK7	Gene names	DYNC1LI1, DNCLI1
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 1 (Dynein light intermediate chain 1, cytosolic) (Dynein light chain A) (DLC-A).

DCP2_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.014880 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CYC6	Gene names	Dcp2
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 2 (EC 3.-.-.-).

DDX46_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.003369 (rank : 78)
Query Neighborhood Hits	70	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

IF2P_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.012268 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	889	Shared Neighborhood Hits	10
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

K0310_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.024617 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	420	Shared Neighborhood Hits	9
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MACF1_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.007346 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	1341	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.008794 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	1321	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

STAU1_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.041936 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	O95793, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2	Gene names	STAU1, STAU
Domain Architecture
Description	Double-stranded RNA-binding protein Staufen homolog 1.

U2AFM_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.014046 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	543	Shared Neighborhood Hits	7
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

AN32C_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.056869 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	O43423	Gene names	ANP32C, PP32R1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1).

AN32D_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.056743 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	O95626, Q6NTC4	Gene names	ANP32D, PP32R2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member D (Phosphoprotein 32-related protein 2) (Tumorigenic protein pp32r2).

NEDD4_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.056420 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	214	Shared Neighborhood Hits	12
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SMUF1_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.054759 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	135	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.054758 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.055468 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

TRBP2_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.063395 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q15633, Q12878	Gene names	TARBP2, TRBP
Domain Architecture
Description	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein).

TRBP2_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.062962 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P97473	Gene names	Tarbp2, Prbp
Domain Architecture
Description	TAR RNA-binding protein 2 (Protamine-1 RNA-binding protein) (PRM-1 RNA-binding protein).

WWP2_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.061556 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.061463 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	118	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

Hits sorted by NC score

DGCR8_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

DGCR8_HUMAN
NC score	0.990863 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

PRKRA_HUMAN
NC score	0.179055 (rank : 3)	θ value	0.00134147 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	O75569, Q53G24, Q6X7T5, Q8NDK4	Gene names	PRKRA, PACT, RAX
Domain Architecture	No domain graphic available
Description	Interferon-inducible double stranded RNA-dependent protein kinase activator A (Protein kinase, interferon-inducible double stranded RNA- dependent activator) (Protein activator of the interferon-induced protein kinase) (PKR-associated protein X) (PKR-associating protein X).

PRKRA_MOUSE
NC score	0.178737 (rank : 4)	θ value	0.00134147 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTX2, Q9CZB7	Gene names	Prkra, Rax
Domain Architecture	No domain graphic available
Description	Interferon-inducible double stranded RNA-dependent protein kinase activator A (Protein kinase, interferon-inducible double stranded RNA- dependent activator) (Protein activator of the interferon-induced protein kinase) (PKR-associated protein X) (PKR-associating protein X) (RAX).

WWTR1_MOUSE
NC score	0.110836 (rank : 5)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	54	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.109499 (rank : 6)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

AN32A_MOUSE
NC score	0.105671 (rank : 7)	θ value	0.0563607 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	O35381, P97437	Gene names	Anp32a, Anp32, Lanp
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein).

AN32C_MOUSE
NC score	0.105671 (rank : 8)	θ value	0.0563607 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	Q64G17	Gene names	Anp32c
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C.

LRRF1_HUMAN
NC score	0.104205 (rank : 9)	θ value	0.00509761 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	625	Shared Neighborhood Hits	15
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

AN32B_HUMAN
NC score	0.099496 (rank : 10)	θ value	0.125558 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	243	Shared Neighborhood Hits	7
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

DSRAD_HUMAN
NC score	0.091339 (rank : 11)	θ value	0.0431538 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P55265, O15223, O43859, O43860, Q9BYM3, Q9BYM4	Gene names	ADAR, ADAR1, DSRAD, IFI4
Domain Architecture
Description	Double-stranded RNA-specific adenosine deaminase (EC 3.5.4.-) (DRADA) (136 kDa double-stranded RNA-binding protein) (P136) (K88DSRBP) (Interferon-inducible protein 4) (IFI-4 protein).

WWP1_MOUSE
NC score	0.091070 (rank : 12)	θ value	0.0563607 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	138	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

YAP1_MOUSE
NC score	0.090064 (rank : 13)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	96	Shared Neighborhood Hits	14
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ITCH_MOUSE
NC score	0.086312 (rank : 14)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	127	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.085669 (rank : 15)	θ value	0.163984 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	162	Shared Neighborhood Hits	15
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP1_HUMAN
NC score	0.085482 (rank : 16)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	262	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

AN32A_HUMAN
NC score	0.081346 (rank : 17)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	234	Shared Neighborhood Hits	7
SwissProt Accessions	P39687	Gene names	ANP32A, C15orf1, LANP, MAPM, PHAP1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp) (Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin).

NED4L_HUMAN
NC score	0.076396 (rank : 18)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	238	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

YAP1_HUMAN
NC score	0.075305 (rank : 19)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	173	Shared Neighborhood Hits	14
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

HTSF1_HUMAN
NC score	0.074142 (rank : 20)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	408	Shared Neighborhood Hits	10
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

LRRF1_MOUSE
NC score	0.073574 (rank : 21)	θ value	1.06291 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	440	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

HTSF1_MOUSE
NC score	0.070776 (rank : 22)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	425	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

NED4L_MOUSE
NC score	0.070312 (rank : 23)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
NC score	0.068532 (rank : 24)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	212	Shared Neighborhood Hits	14
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

AN32B_MOUSE
NC score	0.066852 (rank : 25)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	236	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

TRBP2_HUMAN
NC score	0.063395 (rank : 26)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	70	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q15633, Q12878	Gene names	TARBP2, TRBP
Domain Architecture
Description	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein).

TRBP2_MOUSE
NC score	0.062962 (rank : 27)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	70	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P97473	Gene names	Tarbp2, Prbp
Domain Architecture
Description	TAR RNA-binding protein 2 (Protamine-1 RNA-binding protein) (PRM-1 RNA-binding protein).

WWP2_HUMAN
NC score	0.061556 (rank : 28)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	70	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
NC score	0.061463 (rank : 29)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	70	Target Neighborhood Hits	118	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

AN32C_HUMAN
NC score	0.056869 (rank : 30)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	O43423	Gene names	ANP32C, PP32R1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1).

AN32D_HUMAN
NC score	0.056743 (rank : 31)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	O95626, Q6NTC4	Gene names	ANP32D, PP32R2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member D (Phosphoprotein 32-related protein 2) (Tumorigenic protein pp32r2).

NEDD4_HUMAN
NC score	0.056420 (rank : 32)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	214	Shared Neighborhood Hits	12
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SMUF2_HUMAN
NC score	0.055468 (rank : 33)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
NC score	0.054759 (rank : 34)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	135	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.054758 (rank : 35)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

CABL1_HUMAN
NC score	0.047129 (rank : 36)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN4, Q8N3Y8, Q8NA22, Q9BTG1	Gene names	CABLES1, CABLES
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

STAU1_HUMAN
NC score	0.041936 (rank : 37)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	O95793, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2	Gene names	STAU1, STAU
Domain Architecture
Description	Double-stranded RNA-binding protein Staufen homolog 1.

C2TA_MOUSE
NC score	0.041627 (rank : 38)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

MAP2_HUMAN
NC score	0.041182 (rank : 39)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	348	Shared Neighborhood Hits	9
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MAP2_MOUSE
NC score	0.039944 (rank : 40)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	342	Shared Neighborhood Hits	11
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

LMO7_HUMAN
NC score	0.037959 (rank : 41)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	507	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MAGI2_MOUSE
NC score	0.037835 (rank : 42)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	370	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

GGN_HUMAN
NC score	0.035360 (rank : 43)	θ value	1.06291 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

PAF49_HUMAN
NC score	0.030871 (rank : 44)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	169	Shared Neighborhood Hits	6
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

CN155_HUMAN
NC score	0.029856 (rank : 45)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	385	Shared Neighborhood Hits	8
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

AMPM2_MOUSE
NC score	0.029603 (rank : 46)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O08663	Gene names	Metap2, Mnpep, P67eif2
Domain Architecture
Description	Methionine aminopeptidase 2 (EC 3.4.11.18) (MetAP 2) (Peptidase M 2) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2).

K0310_HUMAN
NC score	0.024617 (rank : 47)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	420	Shared Neighborhood Hits	9
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

NCOR2_HUMAN
NC score	0.024221 (rank : 48)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	870	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NCOR2_MOUSE
NC score	0.022609 (rank : 49)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	790	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

CKAP5_HUMAN
NC score	0.021881 (rank : 50)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	Q14008, Q14668	Gene names	CKAP5, KIAA0097
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor over- expressed protein) (Ch-TOG protein).

UBQL4_MOUSE
NC score	0.021034 (rank : 51)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

UBQL4_HUMAN
NC score	0.020777 (rank : 52)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRR5, Q9BR98, Q9UHX4	Gene names	UBQLN4, C1orf6, UBIN
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

HS90A_MOUSE
NC score	0.020517 (rank : 53)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	155	Shared Neighborhood Hits	3
SwissProt Accessions	P07901	Gene names	Hsp90aa1, Hsp86, Hsp86-1, Hspca
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (Tumor-specific transplantation 86 kDa antigen) (TSTA).

SRC8_HUMAN
NC score	0.018691 (rank : 54)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	269	Shared Neighborhood Hits	6
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.018206 (rank : 55)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

MPP10_HUMAN
NC score	0.017531 (rank : 56)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	306	Shared Neighborhood Hits	6
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

NEB2_HUMAN
NC score	0.017062 (rank : 57)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	883	Shared Neighborhood Hits	17
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

MLL4_HUMAN
NC score	0.016740 (rank : 58)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	722	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NFAT5_MOUSE
NC score	0.015876 (rank : 59)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

DCP2_MOUSE
NC score	0.014880 (rank : 60)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CYC6	Gene names	Dcp2
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 2 (EC 3.-.-.-).

CSKI1_MOUSE
NC score	0.014364 (rank : 61)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	1031	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

U2AFM_MOUSE
NC score	0.014046 (rank : 62)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	543	Shared Neighborhood Hits	7
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

SFPQ_MOUSE
NC score	0.013965 (rank : 63)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	958	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

CYLD_MOUSE
NC score	0.012957 (rank : 64)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

DNJBA_MOUSE
NC score	0.012630 (rank : 65)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QYI5	Gene names	Dnajb10
Domain Architecture
Description	DnaJ homolog subfamily B member 10 (mDJ8).

IF2P_HUMAN
NC score	0.012268 (rank : 66)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	889	Shared Neighborhood Hits	10
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IRX5_MOUSE
NC score	0.010888 (rank : 67)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JKQ4, Q80WV4, Q9JLL5	Gene names	Irx5, Irxb2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2).

DC1L1_HUMAN
NC score	0.010764 (rank : 68)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6G9, Q53HC8, Q53HK7	Gene names	DYNC1LI1, DNCLI1
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 1 (Dynein light intermediate chain 1, cytosolic) (Dynein light chain A) (DLC-A).

ZO1_MOUSE
NC score	0.010451 (rank : 69)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	453	Shared Neighborhood Hits	7
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MACF4_HUMAN
NC score	0.008794 (rank : 70)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	1321	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

CN145_HUMAN
NC score	0.008580 (rank : 71)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	1196	Shared Neighborhood Hits	12
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

WNK1_MOUSE
NC score	0.008429 (rank : 72)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	1179	Shared Neighborhood Hits	10
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CD2L1_HUMAN
NC score	0.007907 (rank : 73)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	1467	Shared Neighborhood Hits	12
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CSKI1_HUMAN
NC score	0.007891 (rank : 74)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	997	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MACF1_HUMAN
NC score	0.007346 (rank : 75)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	1341	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

GP101_MOUSE
NC score	0.006727 (rank : 76)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	916	Shared Neighborhood Hits	6
SwissProt Accessions	Q80T62, Q3UUI9	Gene names	Gpr101
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 101.

KIF3A_MOUSE
NC score	0.006142 (rank : 77)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	715	Shared Neighborhood Hits	8
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

DDX46_MOUSE
NC score	0.003369 (rank : 78)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

ZN710_HUMAN
NC score	0.002825 (rank : 79)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	796	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N1W2, Q6ZMK9, Q8NDU0	Gene names	ZNF710
Domain Architecture	No domain graphic available
Description	Zinc finger protein 710.

ZN710_MOUSE
NC score	0.002030 (rank : 80)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	749	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U288, Q3U341, Q6P9R3, Q8BJH0, Q8BTL6	Gene names	Znf710, Zfp710
Domain Architecture	No domain graphic available
Description	Zinc finger protein 710.