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Network neighborhood for query Sequence : ITCH_HUMAN

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ITCH_HUMAN
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITCH_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	162	Target Neighborhood Hits	162	Shared Neighborhood Hits	162
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	0 (rank : 2)	NC score	0.991555 (rank : 2)
Query Neighborhood Hits	162	Target Neighborhood Hits	127	Shared Neighborhood Hits	112
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	0 (rank : 3)	NC score	0.976085 (rank : 6)
Query Neighborhood Hits	162	Target Neighborhood Hits	262	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	0 (rank : 4)	NC score	0.984252 (rank : 3)
Query Neighborhood Hits	162	Target Neighborhood Hits	138	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	0 (rank : 5)	NC score	0.981269 (rank : 5)
Query Neighborhood Hits	162	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	0 (rank : 6)	NC score	0.983732 (rank : 4)
Query Neighborhood Hits	162	Target Neighborhood Hits	118	Shared Neighborhood Hits	76
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NEDD4_HUMAN
θ value	1.79534e-149 (rank : 7)	NC score	0.911498 (rank : 11)
Query Neighborhood Hits	162	Target Neighborhood Hits	214	Shared Neighborhood Hits	93
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
θ value	1.1637e-148 (rank : 8)	NC score	0.897944 (rank : 12)
Query Neighborhood Hits	162	Target Neighborhood Hits	231	Shared Neighborhood Hits	97
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
θ value	2.59246e-148 (rank : 9)	NC score	0.896707 (rank : 13)
Query Neighborhood Hits	162	Target Neighborhood Hits	238	Shared Neighborhood Hits	100
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
θ value	1.2462e-142 (rank : 10)	NC score	0.915845 (rank : 10)
Query Neighborhood Hits	162	Target Neighborhood Hits	212	Shared Neighborhood Hits	96
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF2_HUMAN
θ value	2.4321e-138 (rank : 11)	NC score	0.959157 (rank : 7)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
θ value	1.16911e-132 (rank : 12)	NC score	0.952810 (rank : 8)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	75
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF1_HUMAN
θ value	2.87963e-131 (rank : 13)	NC score	0.949973 (rank : 9)
Query Neighborhood Hits	162	Target Neighborhood Hits	135	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

HUWE1_HUMAN
θ value	3.44127e-92 (rank : 14)	NC score	0.867007 (rank : 21)
Query Neighborhood Hits	162	Target Neighborhood Hits	443	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	3.44127e-92 (rank : 15)	NC score	0.868130 (rank : 20)
Query Neighborhood Hits	162	Target Neighborhood Hits	406	Shared Neighborhood Hits	44
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HECD2_MOUSE
θ value	1.90589e-58 (rank : 16)	NC score	0.884725 (rank : 14)
Query Neighborhood Hits	162	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
θ value	8.00737e-57 (rank : 17)	NC score	0.881867 (rank : 15)
Query Neighborhood Hits	162	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
θ value	5.93839e-52 (rank : 18)	NC score	0.878127 (rank : 16)
Query Neighborhood Hits	162	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	1.01294e-51 (rank : 19)	NC score	0.877668 (rank : 17)
Query Neighborhood Hits	162	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_HUMAN
θ value	1.72781e-51 (rank : 20)	NC score	0.876023 (rank : 18)
Query Neighborhood Hits	162	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	1.67352e-46 (rank : 21)	NC score	0.869690 (rank : 19)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HERC3_HUMAN
θ value	2.85459e-46 (rank : 22)	NC score	0.728089 (rank : 26)
Query Neighborhood Hits	162	Target Neighborhood Hits	62	Shared Neighborhood Hits	34
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

UBE3C_HUMAN
θ value	2.76489e-41 (rank : 23)	NC score	0.856544 (rank : 22)
Query Neighborhood Hits	162	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	3.99248e-40 (rank : 24)	NC score	0.854857 (rank : 23)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HERC5_HUMAN
θ value	1.08726e-37 (rank : 25)	NC score	0.731914 (rank : 25)
Query Neighborhood Hits	162	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC2_MOUSE
θ value	4.27553e-34 (rank : 26)	NC score	0.623115 (rank : 31)
Query Neighborhood Hits	162	Target Neighborhood Hits	167	Shared Neighborhood Hits	40
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
θ value	4.72714e-33 (rank : 27)	NC score	0.618950 (rank : 32)
Query Neighborhood Hits	162	Target Neighborhood Hits	163	Shared Neighborhood Hits	40
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

TRIPC_HUMAN
θ value	1.0531e-32 (rank : 28)	NC score	0.793786 (rank : 24)
Query Neighborhood Hits	162	Target Neighborhood Hits	319	Shared Neighborhood Hits	43
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HECD1_HUMAN
θ value	1.6852e-22 (rank : 29)	NC score	0.560570 (rank : 33)
Query Neighborhood Hits	162	Target Neighborhood Hits	371	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

EDD1_HUMAN
θ value	7.82807e-20 (rank : 30)	NC score	0.663617 (rank : 30)
Query Neighborhood Hits	162	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	7.82807e-20 (rank : 31)	NC score	0.665051 (rank : 29)
Query Neighborhood Hits	162	Target Neighborhood Hits	167	Shared Neighborhood Hits	35
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD3_MOUSE
θ value	2.13179e-17 (rank : 32)	NC score	0.698160 (rank : 27)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
θ value	8.10077e-17 (rank : 33)	NC score	0.692963 (rank : 28)
Query Neighborhood Hits	162	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

YAP1_MOUSE
θ value	2.20605e-14 (rank : 34)	NC score	0.548078 (rank : 34)
Query Neighborhood Hits	162	Target Neighborhood Hits	96	Shared Neighborhood Hits	50
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

WWOX_HUMAN
θ value	6.41864e-14 (rank : 35)	NC score	0.394377 (rank : 40)
Query Neighborhood Hits	162	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	6.41864e-14 (rank : 36)	NC score	0.390983 (rank : 41)
Query Neighborhood Hits	162	Target Neighborhood Hits	118	Shared Neighborhood Hits	47
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

SAV1_HUMAN
θ value	7.84624e-12 (rank : 37)	NC score	0.526096 (rank : 35)
Query Neighborhood Hits	162	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	7.84624e-12 (rank : 38)	NC score	0.525672 (rank : 36)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

MAGI1_HUMAN
θ value	1.02475e-11 (rank : 39)	NC score	0.299036 (rank : 51)
Query Neighborhood Hits	162	Target Neighborhood Hits	388	Shared Neighborhood Hits	50
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

WWC1_HUMAN
θ value	1.02475e-11 (rank : 40)	NC score	0.435494 (rank : 38)
Query Neighborhood Hits	162	Target Neighborhood Hits	290	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	1.02475e-11 (rank : 41)	NC score	0.434766 (rank : 39)
Query Neighborhood Hits	162	Target Neighborhood Hits	290	Shared Neighborhood Hits	39
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

MAGI2_HUMAN
θ value	8.67504e-11 (rank : 42)	NC score	0.305990 (rank : 49)
Query Neighborhood Hits	162	Target Neighborhood Hits	373	Shared Neighborhood Hits	49
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	8.67504e-11 (rank : 43)	NC score	0.319846 (rank : 48)
Query Neighborhood Hits	162	Target Neighborhood Hits	370	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

ASCC1_HUMAN
θ value	1.47974e-10 (rank : 44)	NC score	0.116423 (rank : 66)
Query Neighborhood Hits	162	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N9N2, Q96EI8, Q9Y307	Gene names	ASCC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

MAGI1_MOUSE
θ value	3.29651e-10 (rank : 45)	NC score	0.297885 (rank : 52)
Query Neighborhood Hits	162	Target Neighborhood Hits	403	Shared Neighborhood Hits	53
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

M4K1_HUMAN
θ value	5.26297e-08 (rank : 46)	NC score	0.010541 (rank : 180)
Query Neighborhood Hits	162	Target Neighborhood Hits	884	Shared Neighborhood Hits	17
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

PKHA5_HUMAN
θ value	5.26297e-08 (rank : 47)	NC score	0.278003 (rank : 53)
Query Neighborhood Hits	162	Target Neighborhood Hits	455	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CI085_HUMAN
θ value	2.21117e-06 (rank : 48)	NC score	0.118575 (rank : 64)
Query Neighborhood Hits	162	Target Neighborhood Hits	33	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MD7, Q5W0N1, Q5W0N3, Q6PJW9, Q86U95	Gene names	C9orf85
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf85.

CD008_HUMAN
θ value	4.92598e-06 (rank : 49)	NC score	0.087240 (rank : 82)
Query Neighborhood Hits	162	Target Neighborhood Hits	330	Shared Neighborhood Hits	20
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

NEK4_HUMAN
θ value	1.43324e-05 (rank : 50)	NC score	0.007968 (rank : 184)
Query Neighborhood Hits	162	Target Neighborhood Hits	883	Shared Neighborhood Hits	16
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

WWTR1_HUMAN
θ value	3.19293e-05 (rank : 51)	NC score	0.376718 (rank : 45)
Query Neighborhood Hits	162	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	3.19293e-05 (rank : 52)	NC score	0.379304 (rank : 44)
Query Neighborhood Hits	162	Target Neighborhood Hits	54	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

BAG3_HUMAN
θ value	5.44631e-05 (rank : 53)	NC score	0.346071 (rank : 47)
Query Neighborhood Hits	162	Target Neighborhood Hits	314	Shared Neighborhood Hits	48
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	7.1131e-05 (rank : 54)	NC score	0.299329 (rank : 50)
Query Neighborhood Hits	162	Target Neighborhood Hits	513	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

RHG12_HUMAN
θ value	7.1131e-05 (rank : 55)	NC score	0.111773 (rank : 68)
Query Neighborhood Hits	162	Target Neighborhood Hits	190	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PIN1_HUMAN
θ value	9.29e-05 (rank : 56)	NC score	0.380748 (rank : 43)
Query Neighborhood Hits	162	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	9.29e-05 (rank : 57)	NC score	0.382027 (rank : 42)
Query Neighborhood Hits	162	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

YAP1_HUMAN
θ value	9.29e-05 (rank : 58)	NC score	0.372774 (rank : 46)
Query Neighborhood Hits	162	Target Neighborhood Hits	173	Shared Neighborhood Hits	58
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

GAS7_MOUSE
θ value	0.000121331 (rank : 59)	NC score	0.256999 (rank : 55)
Query Neighborhood Hits	162	Target Neighborhood Hits	259	Shared Neighborhood Hits	51
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

BCAS4_HUMAN
θ value	0.000158464 (rank : 60)	NC score	0.102023 (rank : 71)
Query Neighborhood Hits	162	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TDM0, Q5TD52, Q5TD53, Q5TD54, Q5U5K7, Q5XKE8, Q8IXI7, Q8NEZ6, Q8TDL9, Q9NX13, Q9Y511	Gene names	BCAS4
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 4.

PINL_HUMAN
θ value	0.000158464 (rank : 61)	NC score	0.441119 (rank : 37)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

MTO1_HUMAN
θ value	0.00102713 (rank : 62)	NC score	0.049708 (rank : 140)
Query Neighborhood Hits	162	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2Z2, Q5SWL2, Q5SWL3, Q5SWL4, Q8NDN7, Q8WZ57, Q96FE6, Q9BS06	Gene names	MTO1
Domain Architecture
Description	Protein MTO1 homolog, mitochondrial precursor.

RHG12_MOUSE
θ value	0.00102713 (rank : 63)	NC score	0.124366 (rank : 63)
Query Neighborhood Hits	162	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GAS7_HUMAN
θ value	0.00134147 (rank : 64)	NC score	0.257442 (rank : 54)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	53
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PACRG_HUMAN
θ value	0.00134147 (rank : 65)	NC score	0.070009 (rank : 102)
Query Neighborhood Hits	162	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q96M98, Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9	Gene names	PACRG, GLUP
Domain Architecture	No domain graphic available
Description	Parkin coregulated gene protein (PARK2 coregulated) (Molecular chaperone/chaperonin-binding protein).

PRP40_HUMAN
θ value	0.00175202 (rank : 66)	NC score	0.202472 (rank : 56)
Query Neighborhood Hits	162	Target Neighborhood Hits	442	Shared Neighborhood Hits	43
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	0.00175202 (rank : 67)	NC score	0.200578 (rank : 57)
Query Neighborhood Hits	162	Target Neighborhood Hits	447	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

STXB4_HUMAN
θ value	0.00228821 (rank : 68)	NC score	0.174785 (rank : 59)
Query Neighborhood Hits	162	Target Neighborhood Hits	616	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	0.00228821 (rank : 69)	NC score	0.175453 (rank : 58)
Query Neighborhood Hits	162	Target Neighborhood Hits	629	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MBB1A_HUMAN
θ value	0.00298849 (rank : 70)	NC score	0.044232 (rank : 147)
Query Neighborhood Hits	162	Target Neighborhood Hits	665	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

SETD2_HUMAN
θ value	0.00390308 (rank : 71)	NC score	0.133295 (rank : 62)
Query Neighborhood Hits	162	Target Neighborhood Hits	412	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

APBB2_HUMAN
θ value	0.0113563 (rank : 72)	NC score	0.156570 (rank : 60)
Query Neighborhood Hits	162	Target Neighborhood Hits	96	Shared Neighborhood Hits	30
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	0.0113563 (rank : 73)	NC score	0.146833 (rank : 61)
Query Neighborhood Hits	162	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

TOLIP_MOUSE
θ value	0.0193708 (rank : 74)	NC score	0.098696 (rank : 72)
Query Neighborhood Hits	162	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

G6PI_HUMAN
θ value	0.0736092 (rank : 75)	NC score	0.046179 (rank : 145)
Query Neighborhood Hits	162	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P06744, Q9BSK5, Q9UHE6	Gene names	GPI
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK) (Sperm antigen 36) (SA-36).

ZN518_HUMAN
θ value	0.125558 (rank : 76)	NC score	0.002414 (rank : 203)
Query Neighborhood Hits	162	Target Neighborhood Hits	780	Shared Neighborhood Hits	6
SwissProt Accessions	Q6AHZ1, O15044, Q32MP4	Gene names	ZNF518, KIAA0335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 518.

DGCR8_HUMAN
θ value	0.163984 (rank : 77)	NC score	0.087550 (rank : 80)
Query Neighborhood Hits	162	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DGCR8_MOUSE
θ value	0.163984 (rank : 78)	NC score	0.085669 (rank : 85)
Query Neighborhood Hits	162	Target Neighborhood Hits	70	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

FA62A_MOUSE
θ value	0.163984 (rank : 79)	NC score	0.111397 (rank : 70)
Query Neighborhood Hits	162	Target Neighborhood Hits	155	Shared Neighborhood Hits	34
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

MYOF_HUMAN
θ value	0.163984 (rank : 80)	NC score	0.068063 (rank : 106)
Query Neighborhood Hits	162	Target Neighborhood Hits	147	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

TOLIP_HUMAN
θ value	0.163984 (rank : 81)	NC score	0.092315 (rank : 75)
Query Neighborhood Hits	162	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

AATK_MOUSE
θ value	0.21417 (rank : 82)	NC score	0.002851 (rank : 201)
Query Neighborhood Hits	162	Target Neighborhood Hits	942	Shared Neighborhood Hits	13
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

BMX_HUMAN
θ value	0.21417 (rank : 83)	NC score	0.003547 (rank : 198)
Query Neighborhood Hits	162	Target Neighborhood Hits	942	Shared Neighborhood Hits	10
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

RIMS2_HUMAN
θ value	0.21417 (rank : 84)	NC score	0.076669 (rank : 93)
Query Neighborhood Hits	162	Target Neighborhood Hits	342	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	0.21417 (rank : 85)	NC score	0.076534 (rank : 94)
Query Neighborhood Hits	162	Target Neighborhood Hits	376	Shared Neighborhood Hits	37
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

ZN619_HUMAN
θ value	0.21417 (rank : 86)	NC score	-0.004428 (rank : 211)
Query Neighborhood Hits	162	Target Neighborhood Hits	749	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N2I2	Gene names	ZNF619
Domain Architecture	No domain graphic available
Description	Zinc finger protein 619.

CBP_HUMAN
θ value	0.365318 (rank : 87)	NC score	0.026113 (rank : 161)
Query Neighborhood Hits	162	Target Neighborhood Hits	941	Shared Neighborhood Hits	30
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

MLL2_HUMAN
θ value	0.47712 (rank : 88)	NC score	0.016359 (rank : 169)
Query Neighborhood Hits	162	Target Neighborhood Hits	1788	Shared Neighborhood Hits	46
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PERF_HUMAN
θ value	0.47712 (rank : 89)	NC score	0.028588 (rank : 156)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

RHG09_HUMAN
θ value	0.47712 (rank : 90)	NC score	0.038172 (rank : 150)
Query Neighborhood Hits	162	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

SETBP_MOUSE
θ value	0.47712 (rank : 91)	NC score	0.026091 (rank : 162)
Query Neighborhood Hits	162	Target Neighborhood Hits	352	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

WBP4_MOUSE
θ value	0.47712 (rank : 92)	NC score	0.116914 (rank : 65)
Query Neighborhood Hits	162	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

CI039_HUMAN
θ value	0.62314 (rank : 93)	NC score	0.008231 (rank : 183)
Query Neighborhood Hits	162	Target Neighborhood Hits	1171	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

DMD_MOUSE
θ value	0.62314 (rank : 94)	NC score	0.038701 (rank : 149)
Query Neighborhood Hits	162	Target Neighborhood Hits	1111	Shared Neighborhood Hits	45
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

MUCDL_HUMAN
θ value	0.62314 (rank : 95)	NC score	0.011866 (rank : 174)
Query Neighborhood Hits	162	Target Neighborhood Hits	777	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

CBP_MOUSE
θ value	0.813845 (rank : 96)	NC score	0.023636 (rank : 163)
Query Neighborhood Hits	162	Target Neighborhood Hits	1051	Shared Neighborhood Hits	37
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

COA2_HUMAN
θ value	0.813845 (rank : 97)	NC score	0.018924 (rank : 168)
Query Neighborhood Hits	162	Target Neighborhood Hits	184	Shared Neighborhood Hits	14
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

ASPP1_MOUSE
θ value	1.06291 (rank : 98)	NC score	0.013270 (rank : 171)
Query Neighborhood Hits	162	Target Neighborhood Hits	1244	Shared Neighborhood Hits	30
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DMD_HUMAN
θ value	1.06291 (rank : 99)	NC score	0.043113 (rank : 148)
Query Neighborhood Hits	162	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

SETBP_HUMAN
θ value	1.06291 (rank : 100)	NC score	0.027267 (rank : 159)
Query Neighborhood Hits	162	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

APBB3_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.112418 (rank : 67)
Query Neighborhood Hits	162	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

G6PI_MOUSE
θ value	1.38821 (rank : 102)	NC score	0.033260 (rank : 154)
Query Neighborhood Hits	162	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P06745	Gene names	Gpi, Gpi1
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK).

ICAM5_MOUSE
θ value	1.38821 (rank : 103)	NC score	0.005436 (rank : 194)
Query Neighborhood Hits	162	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

MAGE1_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.027571 (rank : 157)
Query Neighborhood Hits	162	Target Neighborhood Hits	1389	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PI5PA_HUMAN
θ value	1.38821 (rank : 105)	NC score	0.011379 (rank : 179)
Query Neighborhood Hits	162	Target Neighborhood Hits	749	Shared Neighborhood Hits	27
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

APBB3_MOUSE
θ value	1.81305 (rank : 106)	NC score	0.111675 (rank : 69)
Query Neighborhood Hits	162	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

DHSA_HUMAN
θ value	1.81305 (rank : 107)	NC score	0.022766 (rank : 164)
Query Neighborhood Hits	162	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

FA62A_HUMAN
θ value	1.81305 (rank : 108)	NC score	0.096199 (rank : 73)
Query Neighborhood Hits	162	Target Neighborhood Hits	168	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

HXC10_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.002190 (rank : 204)
Query Neighborhood Hits	162	Target Neighborhood Hits	417	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

MAST4_HUMAN
θ value	1.81305 (rank : 110)	NC score	0.003440 (rank : 199)
Query Neighborhood Hits	162	Target Neighborhood Hits	1804	Shared Neighborhood Hits	36
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

DHSA_MOUSE
θ value	2.36792 (rank : 111)	NC score	0.021536 (rank : 166)
Query Neighborhood Hits	162	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2B3, Q3UH25	Gene names	Sdha
Domain Architecture	No domain graphic available
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

IGHD_HUMAN
θ value	2.36792 (rank : 112)	NC score	0.006008 (rank : 191)
Query Neighborhood Hits	162	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	P01880	Gene names	IGHD
Domain Architecture	No domain graphic available
Description	Ig delta chain C region.

NCOA6_HUMAN
θ value	2.36792 (rank : 113)	NC score	0.011616 (rank : 176)
Query Neighborhood Hits	162	Target Neighborhood Hits	1202	Shared Neighborhood Hits	33
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

WBP4_HUMAN
θ value	2.36792 (rank : 114)	NC score	0.054943 (rank : 128)
Query Neighborhood Hits	162	Target Neighborhood Hits	86	Shared Neighborhood Hits	16
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

DRP2_HUMAN
θ value	3.0926 (rank : 115)	NC score	0.084597 (rank : 86)
Query Neighborhood Hits	162	Target Neighborhood Hits	186	Shared Neighborhood Hits	27
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

NACAM_MOUSE
θ value	3.0926 (rank : 116)	NC score	0.026922 (rank : 160)
Query Neighborhood Hits	162	Target Neighborhood Hits	1866	Shared Neighborhood Hits	56
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PA24A_MOUSE
θ value	3.0926 (rank : 117)	NC score	0.051597 (rank : 137)
Query Neighborhood Hits	162	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

UTRO_HUMAN
θ value	3.0926 (rank : 118)	NC score	0.034278 (rank : 153)
Query Neighborhood Hits	162	Target Neighborhood Hits	960	Shared Neighborhood Hits	39
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

ABEC4_MOUSE
θ value	4.03905 (rank : 119)	NC score	0.013733 (rank : 170)
Query Neighborhood Hits	162	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q497M3	Gene names	Apobec4
Domain Architecture	No domain graphic available
Description	Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4).

CP007_MOUSE
θ value	4.03905 (rank : 120)	NC score	0.007915 (rank : 185)
Query Neighborhood Hits	162	Target Neighborhood Hits	231	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

IF4B_HUMAN
θ value	4.03905 (rank : 121)	NC score	0.012977 (rank : 172)
Query Neighborhood Hits	162	Target Neighborhood Hits	417	Shared Neighborhood Hits	13
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

IP3KB_HUMAN
θ value	4.03905 (rank : 122)	NC score	0.006605 (rank : 187)
Query Neighborhood Hits	162	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

JHD2B_MOUSE
θ value	4.03905 (rank : 123)	NC score	0.005204 (rank : 195)
Query Neighborhood Hits	162	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

OTOF_HUMAN
θ value	4.03905 (rank : 124)	NC score	0.047339 (rank : 143)
Query Neighborhood Hits	162	Target Neighborhood Hits	168	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	4.03905 (rank : 125)	NC score	0.049575 (rank : 141)
Query Neighborhood Hits	162	Target Neighborhood Hits	196	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

PA24A_HUMAN
θ value	4.03905 (rank : 126)	NC score	0.045521 (rank : 146)
Query Neighborhood Hits	162	Target Neighborhood Hits	88	Shared Neighborhood Hits	28
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

TNR6_HUMAN
θ value	4.03905 (rank : 127)	NC score	0.006318 (rank : 188)
Query Neighborhood Hits	162	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	P25445, Q14292, Q14293, Q14294, Q14295, Q16652, Q6SSE9	Gene names	FAS, APT1, FAS1, TNFRSF6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6 precursor (FASLG receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95 antigen).

AFF4_MOUSE
θ value	5.27518 (rank : 128)	NC score	0.008779 (rank : 182)
Query Neighborhood Hits	162	Target Neighborhood Hits	581	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

DYSF_MOUSE
θ value	5.27518 (rank : 129)	NC score	0.046731 (rank : 144)
Query Neighborhood Hits	162	Target Neighborhood Hits	162	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

IF4B_MOUSE
θ value	5.27518 (rank : 130)	NC score	0.011777 (rank : 175)
Query Neighborhood Hits	162	Target Neighborhood Hits	368	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

ITSN1_HUMAN
θ value	5.27518 (rank : 131)	NC score	0.037182 (rank : 151)
Query Neighborhood Hits	162	Target Neighborhood Hits	1757	Shared Neighborhood Hits	57
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	5.27518 (rank : 132)	NC score	0.036984 (rank : 152)
Query Neighborhood Hits	162	Target Neighborhood Hits	1669	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PAF49_HUMAN
θ value	5.27518 (rank : 133)	NC score	0.022400 (rank : 165)
Query Neighborhood Hits	162	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

SIRT1_MOUSE
θ value	5.27518 (rank : 134)	NC score	0.005187 (rank : 196)
Query Neighborhood Hits	162	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SYNJ1_MOUSE
θ value	5.27518 (rank : 135)	NC score	0.012629 (rank : 173)
Query Neighborhood Hits	162	Target Neighborhood Hits	516	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

ADA32_MOUSE
θ value	6.88961 (rank : 136)	NC score	-0.000206 (rank : 208)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

DAF1_MOUSE
θ value	6.88961 (rank : 137)	NC score	0.002675 (rank : 202)
Query Neighborhood Hits	162	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

DDFL1_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.005573 (rank : 193)
Query Neighborhood Hits	162	Target Neighborhood Hits	353	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DOC2B_HUMAN
θ value	6.88961 (rank : 139)	NC score	0.070692 (rank : 100)
Query Neighborhood Hits	162	Target Neighborhood Hits	150	Shared Neighborhood Hits	31
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.069473 (rank : 103)
Query Neighborhood Hits	162	Target Neighborhood Hits	169	Shared Neighborhood Hits	32
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

K0196_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.006088 (rank : 189)
Query Neighborhood Hits	162	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q12768, Q3KQX5, Q8TBQ2	Gene names	KIAA0196
Domain Architecture	No domain graphic available
Description	Protein KIAA0196.

RIMB1_HUMAN
θ value	6.88961 (rank : 142)	NC score	0.000434 (rank : 206)
Query Neighborhood Hits	162	Target Neighborhood Hits	1479	Shared Neighborhood Hits	29
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

UN13B_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.092180 (rank : 76)
Query Neighborhood Hits	162	Target Neighborhood Hits	217	Shared Neighborhood Hits	31
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

WDR7_HUMAN
θ value	6.88961 (rank : 144)	NC score	0.005620 (rank : 192)
Query Neighborhood Hits	162	Target Neighborhood Hits	244	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

AAKG2_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.003068 (rank : 200)
Query Neighborhood Hits	162	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGJ0, Q53Y07, Q6NUI0, Q75MP4, Q9NUZ9, Q9UDN8, Q9ULX8	Gene names	PRKAG2
Domain Architecture
Description	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma-2 chain) (AMPK gamma2) (H91620p).

BIN1_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.011452 (rank : 178)
Query Neighborhood Hits	162	Target Neighborhood Hits	335	Shared Neighborhood Hits	19
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

DCBD1_HUMAN
θ value	8.99809 (rank : 147)	NC score	0.001178 (rank : 205)
Query Neighborhood Hits	162	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

DSCR8_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.020074 (rank : 167)
Query Neighborhood Hits	162	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T75, Q8N3X0, Q8NDY5, Q96B46	Gene names	DSCR8, C21orf65, MTAG2
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 8 (Malignant melanoma-associated protein 1) (MMA-1) (MTAG2 protein).

DYSF_HUMAN
θ value	8.99809 (rank : 149)	NC score	0.056407 (rank : 123)
Query Neighborhood Hits	162	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

GMIP_MOUSE
θ value	8.99809 (rank : 150)	NC score	0.011552 (rank : 177)
Query Neighborhood Hits	162	Target Neighborhood Hits	202	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

ITSN2_MOUSE
θ value	8.99809 (rank : 151)	NC score	0.027565 (rank : 158)
Query Neighborhood Hits	162	Target Neighborhood Hits	1371	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LCP2_HUMAN
θ value	8.99809 (rank : 152)	NC score	0.009096 (rank : 181)
Query Neighborhood Hits	162	Target Neighborhood Hits	531	Shared Neighborhood Hits	21
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

NPCL1_HUMAN
θ value	8.99809 (rank : 153)	NC score	0.007136 (rank : 186)
Query Neighborhood Hits	162	Target Neighborhood Hits	25	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

PA24D_MOUSE
θ value	8.99809 (rank : 154)	NC score	0.048383 (rank : 142)
Query Neighborhood Hits	162	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RAPH1_HUMAN
θ value	8.99809 (rank : 155)	NC score	0.006017 (rank : 190)
Query Neighborhood Hits	162	Target Neighborhood Hits	593	Shared Neighborhood Hits	26
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RIMB1_MOUSE
θ value	8.99809 (rank : 156)	NC score	-0.001589 (rank : 209)
Query Neighborhood Hits	162	Target Neighborhood Hits	1376	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SC24A_MOUSE
θ value	8.99809 (rank : 157)	NC score	0.005148 (rank : 197)
Query Neighborhood Hits	162	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SDK2_MOUSE
θ value	8.99809 (rank : 158)	NC score	-0.002437 (rank : 210)
Query Neighborhood Hits	162	Target Neighborhood Hits	480	Shared Neighborhood Hits	6
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SMC4_HUMAN
θ value	8.99809 (rank : 159)	NC score	-0.000020 (rank : 207)
Query Neighborhood Hits	162	Target Neighborhood Hits	937	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

TGON2_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.033233 (rank : 155)
Query Neighborhood Hits	162	Target Neighborhood Hits	1037	Shared Neighborhood Hits	37
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

UN13A_HUMAN
θ value	8.99809 (rank : 161)	NC score	0.089546 (rank : 78)
Query Neighborhood Hits	162	Target Neighborhood Hits	285	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_MOUSE
θ value	8.99809 (rank : 162)	NC score	0.092389 (rank : 74)
Query Neighborhood Hits	162	Target Neighborhood Hits	210	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

ALS2_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.054736 (rank : 129)
Query Neighborhood Hits	162	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.053181 (rank : 134)
Query Neighborhood Hits	162	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

APBB1_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.072655 (rank : 97)
Query Neighborhood Hits	162	Target Neighborhood Hits	62	Shared Neighborhood Hits	20
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.072168 (rank : 98)
Query Neighborhood Hits	162	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

BAIP3_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.051738 (rank : 136)
Query Neighborhood Hits	162	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

CUL7_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.059119 (rank : 115)
Query Neighborhood Hits	162	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

DOC2A_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.068789 (rank : 105)
Query Neighborhood Hits	162	Target Neighborhood Hits	144	Shared Neighborhood Hits	28
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.072804 (rank : 96)
Query Neighborhood Hits	162	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2G_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.055940 (rank : 125)
Query Neighborhood Hits	162	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

K1333_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.064070 (rank : 111)
Query Neighborhood Hits	162	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PA24B_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.051257 (rank : 138)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24B_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.064531 (rank : 109)
Query Neighborhood Hits	162	Target Neighborhood Hits	102	Shared Neighborhood Hits	28
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PCLO_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.055869 (rank : 126)
Query Neighborhood Hits	162	Target Neighborhood Hits	2046	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.057722 (rank : 120)
Query Neighborhood Hits	162	Target Neighborhood Hits	2275	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RASL1_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.078795 (rank : 92)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.074516 (rank : 95)
Query Neighborhood Hits	162	Target Neighborhood Hits	148	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.071066 (rank : 99)
Query Neighborhood Hits	162	Target Neighborhood Hits	161	Shared Neighborhood Hits	28
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RCBT1_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.062692 (rank : 112)
Query Neighborhood Hits	162	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.064374 (rank : 110)
Query Neighborhood Hits	162	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT2_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.069361 (rank : 104)
Query Neighborhood Hits	162	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.070327 (rank : 101)
Query Neighborhood Hits	162	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.084280 (rank : 87)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.082223 (rank : 89)
Query Neighborhood Hits	162	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.087387 (rank : 81)
Query Neighborhood Hits	162	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.086788 (rank : 83)
Query Neighborhood Hits	162	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RP3A_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.058667 (rank : 116)
Query Neighborhood Hits	162	Target Neighborhood Hits	305	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.055256 (rank : 127)
Query Neighborhood Hits	162	Target Neighborhood Hits	510	Shared Neighborhood Hits	41
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RPGR_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.085780 (rank : 84)
Query Neighborhood Hits	162	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.082397 (rank : 88)
Query Neighborhood Hits	162	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SRGEF_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.090856 (rank : 77)
Query Neighborhood Hits	162	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.088256 (rank : 79)
Query Neighborhood Hits	162	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SYT10_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.057270 (rank : 121)
Query Neighborhood Hits	162	Target Neighborhood Hits	134	Shared Neighborhood Hits	29
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.055945 (rank : 124)
Query Neighborhood Hits	162	Target Neighborhood Hits	133	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.058059 (rank : 117)
Query Neighborhood Hits	162	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.058058 (rank : 118)
Query Neighborhood Hits	162	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.054280 (rank : 131)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.054288 (rank : 130)
Query Neighborhood Hits	162	Target Neighborhood Hits	143	Shared Neighborhood Hits	30
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.059450 (rank : 114)
Query Neighborhood Hits	162	Target Neighborhood Hits	138	Shared Neighborhood Hits	29
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.053914 (rank : 132)
Query Neighborhood Hits	162	Target Neighborhood Hits	140	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT6_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.050323 (rank : 139)
Query Neighborhood Hits	162	Target Neighborhood Hits	132	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT7_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.057789 (rank : 119)
Query Neighborhood Hits	162	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.057227 (rank : 122)
Query Neighborhood Hits	162	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT9_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.052299 (rank : 135)
Query Neighborhood Hits	162	Target Neighborhood Hits	144	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.053563 (rank : 133)
Query Neighborhood Hits	162	Target Neighborhood Hits	148	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

TCRG1_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.064748 (rank : 108)
Query Neighborhood Hits	162	Target Neighborhood Hits	929	Shared Neighborhood Hits	43
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.065497 (rank : 107)
Query Neighborhood Hits	162	Target Neighborhood Hits	947	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

UN13D_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.062539 (rank : 113)
Query Neighborhood Hits	162	Target Neighborhood Hits	117	Shared Neighborhood Hits	24
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

WBS16_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.079992 (rank : 91)
Query Neighborhood Hits	162	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.081734 (rank : 90)
Query Neighborhood Hits	162	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

Hits sorted by NC score

ITCH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	162	Target Neighborhood Hits	162	Shared Neighborhood Hits	162
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
NC score	0.991555 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	162	Target Neighborhood Hits	127	Shared Neighborhood Hits	112
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_MOUSE
NC score	0.984252 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	162	Target Neighborhood Hits	138	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_MOUSE
NC score	0.983732 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	162	Target Neighborhood Hits	118	Shared Neighborhood Hits	76
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.981269 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	162	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
NC score	0.976085 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	162	Target Neighborhood Hits	262	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

SMUF2_HUMAN
NC score	0.959157 (rank : 7)	θ value	2.4321e-138 (rank : 11)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.952810 (rank : 8)	θ value	1.16911e-132 (rank : 12)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	75
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF1_HUMAN
NC score	0.949973 (rank : 9)	θ value	2.87963e-131 (rank : 13)
Query Neighborhood Hits	162	Target Neighborhood Hits	135	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

NEDD4_MOUSE
NC score	0.915845 (rank : 10)	θ value	1.2462e-142 (rank : 10)
Query Neighborhood Hits	162	Target Neighborhood Hits	212	Shared Neighborhood Hits	96
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NEDD4_HUMAN
NC score	0.911498 (rank : 11)	θ value	1.79534e-149 (rank : 7)
Query Neighborhood Hits	162	Target Neighborhood Hits	214	Shared Neighborhood Hits	93
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.897944 (rank : 12)	θ value	1.1637e-148 (rank : 8)
Query Neighborhood Hits	162	Target Neighborhood Hits	231	Shared Neighborhood Hits	97
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.896707 (rank : 13)	θ value	2.59246e-148 (rank : 9)
Query Neighborhood Hits	162	Target Neighborhood Hits	238	Shared Neighborhood Hits	100
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

HECD2_MOUSE
NC score	0.884725 (rank : 14)	θ value	1.90589e-58 (rank : 16)
Query Neighborhood Hits	162	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.881867 (rank : 15)	θ value	8.00737e-57 (rank : 17)
Query Neighborhood Hits	162	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
NC score	0.878127 (rank : 16)	θ value	5.93839e-52 (rank : 18)
Query Neighborhood Hits	162	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.877668 (rank : 17)	θ value	1.01294e-51 (rank : 19)
Query Neighborhood Hits	162	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_HUMAN
NC score	0.876023 (rank : 18)	θ value	1.72781e-51 (rank : 20)
Query Neighborhood Hits	162	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.869690 (rank : 19)	θ value	1.67352e-46 (rank : 21)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HUWE1_MOUSE
NC score	0.868130 (rank : 20)	θ value	3.44127e-92 (rank : 15)
Query Neighborhood Hits	162	Target Neighborhood Hits	406	Shared Neighborhood Hits	44
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.867007 (rank : 21)	θ value	3.44127e-92 (rank : 14)
Query Neighborhood Hits	162	Target Neighborhood Hits	443	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

UBE3C_HUMAN
NC score	0.856544 (rank : 22)	θ value	2.76489e-41 (rank : 23)
Query Neighborhood Hits	162	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.854857 (rank : 23)	θ value	3.99248e-40 (rank : 24)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.793786 (rank : 24)	θ value	1.0531e-32 (rank : 28)
Query Neighborhood Hits	162	Target Neighborhood Hits	319	Shared Neighborhood Hits	43
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
NC score	0.731914 (rank : 25)	θ value	1.08726e-37 (rank : 25)
Query Neighborhood Hits	162	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.728089 (rank : 26)	θ value	2.85459e-46 (rank : 22)
Query Neighborhood Hits	162	Target Neighborhood Hits	62	Shared Neighborhood Hits	34
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD3_MOUSE
NC score	0.698160 (rank : 27)	θ value	2.13179e-17 (rank : 32)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.692963 (rank : 28)	θ value	8.10077e-17 (rank : 33)
Query Neighborhood Hits	162	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.665051 (rank : 29)	θ value	7.82807e-20 (rank : 31)
Query Neighborhood Hits	162	Target Neighborhood Hits	167	Shared Neighborhood Hits	35
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.663617 (rank : 30)	θ value	7.82807e-20 (rank : 30)
Query Neighborhood Hits	162	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HERC2_MOUSE
NC score	0.623115 (rank : 31)	θ value	4.27553e-34 (rank : 26)
Query Neighborhood Hits	162	Target Neighborhood Hits	167	Shared Neighborhood Hits	40
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.618950 (rank : 32)	θ value	4.72714e-33 (rank : 27)
Query Neighborhood Hits	162	Target Neighborhood Hits	163	Shared Neighborhood Hits	40
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.560570 (rank : 33)	θ value	1.6852e-22 (rank : 29)
Query Neighborhood Hits	162	Target Neighborhood Hits	371	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

YAP1_MOUSE
NC score	0.548078 (rank : 34)	θ value	2.20605e-14 (rank : 34)
Query Neighborhood Hits	162	Target Neighborhood Hits	96	Shared Neighborhood Hits	50
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
NC score	0.526096 (rank : 35)	θ value	7.84624e-12 (rank : 37)
Query Neighborhood Hits	162	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.525672 (rank : 36)	θ value	7.84624e-12 (rank : 38)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

PINL_HUMAN
NC score	0.441119 (rank : 37)	θ value	0.000158464 (rank : 61)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	42
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWC1_HUMAN
NC score	0.435494 (rank : 38)	θ value	1.02475e-11 (rank : 40)
Query Neighborhood Hits	162	Target Neighborhood Hits	290	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.434766 (rank : 39)	θ value	1.02475e-11 (rank : 41)
Query Neighborhood Hits	162	Target Neighborhood Hits	290	Shared Neighborhood Hits	39
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
NC score	0.394377 (rank : 40)	θ value	6.41864e-14 (rank : 35)
Query Neighborhood Hits	162	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.390983 (rank : 41)	θ value	6.41864e-14 (rank : 36)
Query Neighborhood Hits	162	Target Neighborhood Hits	118	Shared Neighborhood Hits	47
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

PIN1_MOUSE
NC score	0.382027 (rank : 42)	θ value	9.29e-05 (rank : 57)
Query Neighborhood Hits	162	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_HUMAN
NC score	0.380748 (rank : 43)	θ value	9.29e-05 (rank : 56)
Query Neighborhood Hits	162	Target Neighborhood Hits	59	Shared Neighborhood Hits	45
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWTR1_MOUSE
NC score	0.379304 (rank : 44)	θ value	3.19293e-05 (rank : 52)
Query Neighborhood Hits	162	Target Neighborhood Hits	54	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.376718 (rank : 45)	θ value	3.19293e-05 (rank : 51)
Query Neighborhood Hits	162	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.372774 (rank : 46)	θ value	9.29e-05 (rank : 58)
Query Neighborhood Hits	162	Target Neighborhood Hits	173	Shared Neighborhood Hits	58
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_HUMAN
NC score	0.346071 (rank : 47)	θ value	5.44631e-05 (rank : 53)
Query Neighborhood Hits	162	Target Neighborhood Hits	314	Shared Neighborhood Hits	48
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

MAGI2_MOUSE
NC score	0.319846 (rank : 48)	θ value	8.67504e-11 (rank : 43)
Query Neighborhood Hits	162	Target Neighborhood Hits	370	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.305990 (rank : 49)	θ value	8.67504e-11 (rank : 42)
Query Neighborhood Hits	162	Target Neighborhood Hits	373	Shared Neighborhood Hits	49
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

BAG3_MOUSE
NC score	0.299329 (rank : 50)	θ value	7.1131e-05 (rank : 54)
Query Neighborhood Hits	162	Target Neighborhood Hits	513	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

MAGI1_HUMAN
NC score	0.299036 (rank : 51)	θ value	1.02475e-11 (rank : 39)
Query Neighborhood Hits	162	Target Neighborhood Hits	388	Shared Neighborhood Hits	50
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.297885 (rank : 52)	θ value	3.29651e-10 (rank : 45)
Query Neighborhood Hits	162	Target Neighborhood Hits	403	Shared Neighborhood Hits	53
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PKHA5_HUMAN
NC score	0.278003 (rank : 53)	θ value	5.26297e-08 (rank : 47)
Query Neighborhood Hits	162	Target Neighborhood Hits	455	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAS7_HUMAN
NC score	0.257442 (rank : 54)	θ value	0.00134147 (rank : 64)
Query Neighborhood Hits	162	Target Neighborhood Hits	258	Shared Neighborhood Hits	53
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.256999 (rank : 55)	θ value	0.000121331 (rank : 59)
Query Neighborhood Hits	162	Target Neighborhood Hits	259	Shared Neighborhood Hits	51
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PRP40_HUMAN
NC score	0.202472 (rank : 56)	θ value	0.00175202 (rank : 66)
Query Neighborhood Hits	162	Target Neighborhood Hits	442	Shared Neighborhood Hits	43
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.200578 (rank : 57)	θ value	0.00175202 (rank : 67)
Query Neighborhood Hits	162	Target Neighborhood Hits	447	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

STXB4_MOUSE
NC score	0.175453 (rank : 58)	θ value	0.00228821 (rank : 69)
Query Neighborhood Hits	162	Target Neighborhood Hits	629	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.174785 (rank : 59)	θ value	0.00228821 (rank : 68)
Query Neighborhood Hits	162	Target Neighborhood Hits	616	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBB2_HUMAN
NC score	0.156570 (rank : 60)	θ value	0.0113563 (rank : 72)
Query Neighborhood Hits	162	Target Neighborhood Hits	96	Shared Neighborhood Hits	30
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
NC score	0.146833 (rank : 61)	θ value	0.0113563 (rank : 73)
Query Neighborhood Hits	162	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

SETD2_HUMAN
NC score	0.133295 (rank : 62)	θ value	0.00390308 (rank : 71)
Query Neighborhood Hits	162	Target Neighborhood Hits	412	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

RHG12_MOUSE
NC score	0.124366 (rank : 63)	θ value	0.00102713 (rank : 63)
Query Neighborhood Hits	162	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CI085_HUMAN
NC score	0.118575 (rank : 64)	θ value	2.21117e-06 (rank : 48)
Query Neighborhood Hits	162	Target Neighborhood Hits	33	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MD7, Q5W0N1, Q5W0N3, Q6PJW9, Q86U95	Gene names	C9orf85
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf85.

WBP4_MOUSE
NC score	0.116914 (rank : 65)	θ value	0.47712 (rank : 92)
Query Neighborhood Hits	162	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

ASCC1_HUMAN
NC score	0.116423 (rank : 66)	θ value	1.47974e-10 (rank : 44)
Query Neighborhood Hits	162	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N9N2, Q96EI8, Q9Y307	Gene names	ASCC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

APBB3_HUMAN
NC score	0.112418 (rank : 67)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	162	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

RHG12_HUMAN
NC score	0.111773 (rank : 68)	θ value	7.1131e-05 (rank : 55)
Query Neighborhood Hits	162	Target Neighborhood Hits	190	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

APBB3_MOUSE
NC score	0.111675 (rank : 69)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	162	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

FA62A_MOUSE
NC score	0.111397 (rank : 70)	θ value	0.163984 (rank : 79)
Query Neighborhood Hits	162	Target Neighborhood Hits	155	Shared Neighborhood Hits	34
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

BCAS4_HUMAN
NC score	0.102023 (rank : 71)	θ value	0.000158464 (rank : 60)
Query Neighborhood Hits	162	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TDM0, Q5TD52, Q5TD53, Q5TD54, Q5U5K7, Q5XKE8, Q8IXI7, Q8NEZ6, Q8TDL9, Q9NX13, Q9Y511	Gene names	BCAS4
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 4.

TOLIP_MOUSE
NC score	0.098696 (rank : 72)	θ value	0.0193708 (rank : 74)
Query Neighborhood Hits	162	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

FA62A_HUMAN
NC score	0.096199 (rank : 73)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	162	Target Neighborhood Hits	168	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

UN13B_MOUSE
NC score	0.092389 (rank : 74)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	162	Target Neighborhood Hits	210	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

TOLIP_HUMAN
NC score	0.092315 (rank : 75)	θ value	0.163984 (rank : 81)
Query Neighborhood Hits	162	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

UN13B_HUMAN
NC score	0.092180 (rank : 76)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	162	Target Neighborhood Hits	217	Shared Neighborhood Hits	31
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SRGEF_HUMAN
NC score	0.090856 (rank : 77)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	162	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

UN13A_HUMAN
NC score	0.089546 (rank : 78)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	162	Target Neighborhood Hits	285	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

SRGEF_MOUSE
NC score	0.088256 (rank : 79)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	162	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

DGCR8_HUMAN
NC score	0.087550 (rank : 80)	θ value	0.163984 (rank : 77)
Query Neighborhood Hits	162	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

RCC2_HUMAN
NC score	0.087387 (rank : 81)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	162	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

CD008_HUMAN
NC score	0.087240 (rank : 82)	θ value	4.92598e-06 (rank : 49)
Query Neighborhood Hits	162	Target Neighborhood Hits	330	Shared Neighborhood Hits	20
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

RCC2_MOUSE
NC score	0.086788 (rank : 83)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	162	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RPGR_HUMAN
NC score	0.085780 (rank : 84)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	162	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

DGCR8_MOUSE
NC score	0.085669 (rank : 85)	θ value	0.163984 (rank : 78)
Query Neighborhood Hits	162	Target Neighborhood Hits	70	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

DRP2_HUMAN
NC score	0.084597 (rank : 86)	θ value	3.0926 (rank : 115)
Query Neighborhood Hits	162	Target Neighborhood Hits	186	Shared Neighborhood Hits	27
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

RCC1_HUMAN
NC score	0.084280 (rank : 87)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	162	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RPGR_MOUSE
NC score	0.082397 (rank : 88)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	162	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RCC1_MOUSE
NC score	0.082223 (rank : 89)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	162	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

WBS16_MOUSE
NC score	0.081734 (rank : 90)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	162	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WBS16_HUMAN
NC score	0.079992 (rank : 91)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	162	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

RASL1_HUMAN
NC score	0.078795 (rank : 92)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RIMS2_HUMAN
NC score	0.076669 (rank : 93)	θ value	0.21417 (rank : 84)
Query Neighborhood Hits	162	Target Neighborhood Hits	342	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.076534 (rank : 94)	θ value	0.21417 (rank : 85)
Query Neighborhood Hits	162	Target Neighborhood Hits	376	Shared Neighborhood Hits	37
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RASL1_MOUSE
NC score	0.074516 (rank : 95)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	162	Target Neighborhood Hits	148	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

DOC2A_MOUSE
NC score	0.072804 (rank : 96)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	162	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

APBB1_HUMAN
NC score	0.072655 (rank : 97)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	162	Target Neighborhood Hits	62	Shared Neighborhood Hits	20
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.072168 (rank : 98)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	162	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

RASL2_HUMAN
NC score	0.071066 (rank : 99)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	162	Target Neighborhood Hits	161	Shared Neighborhood Hits	28
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

DOC2B_HUMAN
NC score	0.070692 (rank : 100)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	162	Target Neighborhood Hits	150	Shared Neighborhood Hits	31
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RCBT2_MOUSE
NC score	0.070327 (rank : 101)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	162	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

PACRG_HUMAN
NC score	0.070009 (rank : 102)	θ value	0.00134147 (rank : 65)
Query Neighborhood Hits	162	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q96M98, Q6IMB8, Q8IZM1, Q8NHP5, Q9H1V9	Gene names	PACRG, GLUP
Domain Architecture	No domain graphic available
Description	Parkin coregulated gene protein (PARK2 coregulated) (Molecular chaperone/chaperonin-binding protein).

DOC2B_MOUSE
NC score	0.069473 (rank : 103)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	162	Target Neighborhood Hits	169	Shared Neighborhood Hits	32
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RCBT2_HUMAN
NC score	0.069361 (rank : 104)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	162	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

DOC2A_HUMAN
NC score	0.068789 (rank : 105)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	162	Target Neighborhood Hits	144	Shared Neighborhood Hits	28
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

MYOF_HUMAN
NC score	0.068063 (rank : 106)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	162	Target Neighborhood Hits	147	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

TCRG1_MOUSE
NC score	0.065497 (rank : 107)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	162	Target Neighborhood Hits	947	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TCRG1_HUMAN
NC score	0.064748 (rank : 108)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	162	Target Neighborhood Hits	929	Shared Neighborhood Hits	43
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

PA24B_MOUSE
NC score	0.064531 (rank : 109)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	162	Target Neighborhood Hits	102	Shared Neighborhood Hits	28
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RCBT1_MOUSE
NC score	0.064374 (rank : 110)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	162	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

K1333_MOUSE
NC score	0.064070 (rank : 111)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	162	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

RCBT1_HUMAN
NC score	0.062692 (rank : 112)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	162	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

UN13D_HUMAN
NC score	0.062539 (rank : 113)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	162	Target Neighborhood Hits	117	Shared Neighborhood Hits	24
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

SYT5_HUMAN
NC score	0.059450 (rank : 114)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	162	Target Neighborhood Hits	138	Shared Neighborhood Hits	29
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

CUL7_HUMAN
NC score	0.059119 (rank : 115)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	162	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

RP3A_HUMAN
NC score	0.058667 (rank : 116)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	162	Target Neighborhood Hits	305	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT1_HUMAN
NC score	0.058059 (rank : 117)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	162	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.058058 (rank : 118)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	162	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT7_HUMAN
NC score	0.057789 (rank : 119)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	162	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

PCLO_MOUSE
NC score	0.057722 (rank : 120)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	162	Target Neighborhood Hits	2275	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYT10_HUMAN
NC score	0.057270 (rank : 121)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	162	Target Neighborhood Hits	134	Shared Neighborhood Hits	29
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT7_MOUSE
NC score	0.057227 (rank : 122)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	162	Target Neighborhood Hits	137	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

DYSF_HUMAN
NC score	0.056407 (rank : 123)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	162	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

SYT10_MOUSE
NC score	0.055945 (rank : 124)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	162	Target Neighborhood Hits	133	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2G_MOUSE
NC score	0.055940 (rank : 125)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	162	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

PCLO_HUMAN
NC score	0.055869 (rank : 126)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	162	Target Neighborhood Hits	2046	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RP3A_MOUSE
NC score	0.055256 (rank : 127)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	162	Target Neighborhood Hits	510	Shared Neighborhood Hits	41
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

WBP4_HUMAN
NC score	0.054943 (rank : 128)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	162	Target Neighborhood Hits	86	Shared Neighborhood Hits	16
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

ALS2_HUMAN
NC score	0.054736 (rank : 129)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	162	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SYT2_MOUSE
NC score	0.054288 (rank : 130)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	162	Target Neighborhood Hits	143	Shared Neighborhood Hits	30
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.054280 (rank : 131)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	162	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_MOUSE
NC score	0.053914 (rank : 132)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	162	Target Neighborhood Hits	140	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT9_MOUSE
NC score	0.053563 (rank : 133)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	162	Target Neighborhood Hits	148	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

ALS2_MOUSE
NC score	0.053181 (rank : 134)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	162	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SYT9_HUMAN
NC score	0.052299 (rank : 135)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	162	Target Neighborhood Hits	144	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

BAIP3_MOUSE
NC score	0.051738 (rank : 136)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	162	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

PA24A_MOUSE
NC score	0.051597 (rank : 137)	θ value	3.0926 (rank : 117)
Query Neighborhood Hits	162	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24B_HUMAN
NC score	0.051257 (rank : 138)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	162	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

SYT6_MOUSE
NC score	0.050323 (rank : 139)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	162	Target Neighborhood Hits	132	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

MTO1_HUMAN
NC score	0.049708 (rank : 140)	θ value	0.00102713 (rank : 62)
Query Neighborhood Hits	162	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2Z2, Q5SWL2, Q5SWL3, Q5SWL4, Q8NDN7, Q8WZ57, Q96FE6, Q9BS06	Gene names	MTO1
Domain Architecture
Description	Protein MTO1 homolog, mitochondrial precursor.

OTOF_MOUSE
NC score	0.049575 (rank : 141)	θ value	4.03905 (rank : 125)
Query Neighborhood Hits	162	Target Neighborhood Hits	196	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

PA24D_MOUSE
NC score	0.048383 (rank : 142)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	162	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

OTOF_HUMAN
NC score	0.047339 (rank : 143)	θ value	4.03905 (rank : 124)
Query Neighborhood Hits	162	Target Neighborhood Hits	168	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

DYSF_MOUSE
NC score	0.046731 (rank : 144)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	162	Target Neighborhood Hits	162	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

G6PI_HUMAN
NC score	0.046179 (rank : 145)	θ value	0.0736092 (rank : 75)
Query Neighborhood Hits	162	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P06744, Q9BSK5, Q9UHE6	Gene names	GPI
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK) (Sperm antigen 36) (SA-36).

PA24A_HUMAN
NC score	0.045521 (rank : 146)	θ value	4.03905 (rank : 126)
Query Neighborhood Hits	162	Target Neighborhood Hits	88	Shared Neighborhood Hits	28
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

MBB1A_HUMAN
NC score	0.044232 (rank : 147)	θ value	0.00298849 (rank : 70)
Query Neighborhood Hits	162	Target Neighborhood Hits	665	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

DMD_HUMAN
NC score	0.043113 (rank : 148)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	162	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
NC score	0.038701 (rank : 149)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	162	Target Neighborhood Hits	1111	Shared Neighborhood Hits	45
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

RHG09_HUMAN
NC score	0.038172 (rank : 150)	θ value	0.47712 (rank : 90)
Query Neighborhood Hits	162	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

ITSN1_HUMAN
NC score	0.037182 (rank : 151)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	162	Target Neighborhood Hits	1757	Shared Neighborhood Hits	57
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.036984 (rank : 152)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	162	Target Neighborhood Hits	1669	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

UTRO_HUMAN
NC score	0.034278 (rank : 153)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	162	Target Neighborhood Hits	960	Shared Neighborhood Hits	39
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

G6PI_MOUSE
NC score	0.033260 (rank : 154)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	162	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P06745	Gene names	Gpi, Gpi1
Domain Architecture
Description	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Neuroleukin) (NLK).

TGON2_HUMAN
NC score	0.033233 (rank : 155)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	162	Target Neighborhood Hits	1037	Shared Neighborhood Hits	37
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

PERF_HUMAN
NC score	0.028588 (rank : 156)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	162	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

MAGE1_HUMAN
NC score	0.027571 (rank : 157)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	162	Target Neighborhood Hits	1389	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

ITSN2_MOUSE
NC score	0.027565 (rank : 158)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	162	Target Neighborhood Hits	1371	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SETBP_HUMAN
NC score	0.027267 (rank : 159)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	162	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

NACAM_MOUSE
NC score	0.026922 (rank : 160)	θ value	3.0926 (rank : 116)
Query Neighborhood Hits	162	Target Neighborhood Hits	1866	Shared Neighborhood Hits	56
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

CBP_HUMAN
NC score	0.026113 (rank : 161)	θ value	0.365318 (rank : 87)
Query Neighborhood Hits	162	Target Neighborhood Hits	941	Shared Neighborhood Hits	30
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SETBP_MOUSE
NC score	0.026091 (rank : 162)	θ value	0.47712 (rank : 91)
Query Neighborhood Hits	162	Target Neighborhood Hits	352	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

CBP_MOUSE
NC score	0.023636 (rank : 163)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	162	Target Neighborhood Hits	1051	Shared Neighborhood Hits	37
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DHSA_HUMAN
NC score	0.022766 (rank : 164)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	162	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

PAF49_HUMAN
NC score	0.022400 (rank : 165)	θ value	5.27518 (rank : 133)
Query Neighborhood Hits	162	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

DHSA_MOUSE
NC score	0.021536 (rank : 166)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	162	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2B3, Q3UH25	Gene names	Sdha
Domain Architecture	No domain graphic available
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

DSCR8_HUMAN
NC score	0.020074 (rank : 167)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	162	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T75, Q8N3X0, Q8NDY5, Q96B46	Gene names	DSCR8, C21orf65, MTAG2
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 8 (Malignant melanoma-associated protein 1) (MMA-1) (MTAG2 protein).

COA2_HUMAN
NC score	0.018924 (rank : 168)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	162	Target Neighborhood Hits	184	Shared Neighborhood Hits	14
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

MLL2_HUMAN
NC score	0.016359 (rank : 169)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	162	Target Neighborhood Hits	1788	Shared Neighborhood Hits	46
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ABEC4_MOUSE
NC score	0.013733 (rank : 170)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	162	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q497M3	Gene names	Apobec4
Domain Architecture	No domain graphic available
Description	Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4).

ASPP1_MOUSE
NC score	0.013270 (rank : 171)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	162	Target Neighborhood Hits	1244	Shared Neighborhood Hits	30
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

IF4B_HUMAN
NC score	0.012977 (rank : 172)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	162	Target Neighborhood Hits	417	Shared Neighborhood Hits	13
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

SYNJ1_MOUSE
NC score	0.012629 (rank : 173)	θ value	5.27518 (rank : 135)
Query Neighborhood Hits	162	Target Neighborhood Hits	516	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

MUCDL_HUMAN
NC score	0.011866 (rank : 174)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	162	Target Neighborhood Hits	777	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

IF4B_MOUSE
NC score	0.011777 (rank : 175)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	162	Target Neighborhood Hits	368	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

NCOA6_HUMAN
NC score	0.011616 (rank : 176)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	162	Target Neighborhood Hits	1202	Shared Neighborhood Hits	33
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

GMIP_MOUSE
NC score	0.011552 (rank : 177)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	162	Target Neighborhood Hits	202	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

BIN1_HUMAN
NC score	0.011452 (rank : 178)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	162	Target Neighborhood Hits	335	Shared Neighborhood Hits	19
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

PI5PA_HUMAN
NC score	0.011379 (rank : 179)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	162	Target Neighborhood Hits	749	Shared Neighborhood Hits	27
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

M4K1_HUMAN
NC score	0.010541 (rank : 180)	θ value	5.26297e-08 (rank : 46)
Query Neighborhood Hits	162	Target Neighborhood Hits	884	Shared Neighborhood Hits	17
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

LCP2_HUMAN
NC score	0.009096 (rank : 181)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	162	Target Neighborhood Hits	531	Shared Neighborhood Hits	21
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

AFF4_MOUSE
NC score	0.008779 (rank : 182)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	162	Target Neighborhood Hits	581	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

CI039_HUMAN
NC score	0.008231 (rank : 183)	θ value	0.62314 (rank : 93)
Query Neighborhood Hits	162	Target Neighborhood Hits	1171	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

NEK4_HUMAN
NC score	0.007968 (rank : 184)	θ value	1.43324e-05 (rank : 50)
Query Neighborhood Hits	162	Target Neighborhood Hits	883	Shared Neighborhood Hits	16
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

CP007_MOUSE
NC score	0.007915 (rank : 185)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	162	Target Neighborhood Hits	231	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

NPCL1_HUMAN
NC score	0.007136 (rank : 186)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	162	Target Neighborhood Hits	25	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

IP3KB_HUMAN
NC score	0.006605 (rank : 187)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	162	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

TNR6_HUMAN
NC score	0.006318 (rank : 188)	θ value	4.03905 (rank : 127)
Query Neighborhood Hits	162	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	P25445, Q14292, Q14293, Q14294, Q14295, Q16652, Q6SSE9	Gene names	FAS, APT1, FAS1, TNFRSF6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6 precursor (FASLG receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95 antigen).

K0196_HUMAN
NC score	0.006088 (rank : 189)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	162	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q12768, Q3KQX5, Q8TBQ2	Gene names	KIAA0196
Domain Architecture	No domain graphic available
Description	Protein KIAA0196.

RAPH1_HUMAN
NC score	0.006017 (rank : 190)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	162	Target Neighborhood Hits	593	Shared Neighborhood Hits	26
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

IGHD_HUMAN
NC score	0.006008 (rank : 191)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	162	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	P01880	Gene names	IGHD
Domain Architecture	No domain graphic available
Description	Ig delta chain C region.

WDR7_HUMAN
NC score	0.005620 (rank : 192)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	162	Target Neighborhood Hits	244	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

DDFL1_HUMAN
NC score	0.005573 (rank : 193)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	162	Target Neighborhood Hits	353	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

ICAM5_MOUSE
NC score	0.005436 (rank : 194)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	162	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

JHD2B_MOUSE
NC score	0.005204 (rank : 195)	θ value	4.03905 (rank : 123)
Query Neighborhood Hits	162	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

SIRT1_MOUSE
NC score	0.005187 (rank : 196)	θ value	5.27518 (rank : 134)
Query Neighborhood Hits	162	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

SC24A_MOUSE
NC score	0.005148 (rank : 197)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	162	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

BMX_HUMAN
NC score	0.003547 (rank : 198)	θ value	0.21417 (rank : 83)
Query Neighborhood Hits	162	Target Neighborhood Hits	942	Shared Neighborhood Hits	10
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

MAST4_HUMAN
NC score	0.003440 (rank : 199)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	162	Target Neighborhood Hits	1804	Shared Neighborhood Hits	36
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

AAKG2_HUMAN
NC score	0.003068 (rank : 200)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	162	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGJ0, Q53Y07, Q6NUI0, Q75MP4, Q9NUZ9, Q9UDN8, Q9ULX8	Gene names	PRKAG2
Domain Architecture
Description	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma-2 chain) (AMPK gamma2) (H91620p).

AATK_MOUSE
NC score	0.002851 (rank : 201)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	162	Target Neighborhood Hits	942	Shared Neighborhood Hits	13
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

DAF1_MOUSE
NC score	0.002675 (rank : 202)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	162	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

ZN518_HUMAN
NC score	0.002414 (rank : 203)	θ value	0.125558 (rank : 76)
Query Neighborhood Hits	162	Target Neighborhood Hits	780	Shared Neighborhood Hits	6
SwissProt Accessions	Q6AHZ1, O15044, Q32MP4	Gene names	ZNF518, KIAA0335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 518.

HXC10_HUMAN
NC score	0.002190 (rank : 204)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	162	Target Neighborhood Hits	417	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

DCBD1_HUMAN
NC score	0.001178 (rank : 205)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	162	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

RIMB1_HUMAN
NC score	0.000434 (rank : 206)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	162	Target Neighborhood Hits	1479	Shared Neighborhood Hits	29
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SMC4_HUMAN
NC score	-0.000020 (rank : 207)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	162	Target Neighborhood Hits	937	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

ADA32_MOUSE
NC score	-0.000206 (rank : 208)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	162	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

RIMB1_MOUSE
NC score	-0.001589 (rank : 209)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	162	Target Neighborhood Hits	1376	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SDK2_MOUSE
NC score	-0.002437 (rank : 210)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	162	Target Neighborhood Hits	480	Shared Neighborhood Hits	6
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

ZN619_HUMAN
NC score	-0.004428 (rank : 211)	θ value	0.21417 (rank : 86)
Query Neighborhood Hits	162	Target Neighborhood Hits	749	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N2I2	Gene names	ZNF619
Domain Architecture	No domain graphic available
Description	Zinc finger protein 619.