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Network neighborhood for query Sequence : OTOF_HUMAN

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OTOF_HUMAN
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DYSF_HUMAN
θ value	0 (rank : 1)	NC score	0.916488 (rank : 4)
Query Neighborhood Hits	168	Target Neighborhood Hits	170	Shared Neighborhood Hits	102
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

DYSF_MOUSE
θ value	0 (rank : 2)	NC score	0.912931 (rank : 5)
Query Neighborhood Hits	168	Target Neighborhood Hits	162	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

MYOF_HUMAN
θ value	0 (rank : 3)	NC score	0.920959 (rank : 3)
Query Neighborhood Hits	168	Target Neighborhood Hits	147	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

OTOF_HUMAN
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	168	Target Neighborhood Hits	168	Shared Neighborhood Hits	168
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	0 (rank : 5)	NC score	0.993605 (rank : 2)
Query Neighborhood Hits	168	Target Neighborhood Hits	196	Shared Neighborhood Hits	137
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

RASL1_HUMAN
θ value	2.28291e-11 (rank : 6)	NC score	0.441897 (rank : 6)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	97
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	3.29651e-10 (rank : 7)	NC score	0.427255 (rank : 7)
Query Neighborhood Hits	168	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

PCLO_MOUSE
θ value	6.87365e-08 (rank : 8)	NC score	0.283964 (rank : 52)
Query Neighborhood Hits	168	Target Neighborhood Hits	2275	Shared Neighborhood Hits	120
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RASL2_HUMAN
θ value	2.61198e-07 (rank : 9)	NC score	0.414013 (rank : 8)
Query Neighborhood Hits	168	Target Neighborhood Hits	161	Shared Neighborhood Hits	99
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

PCLO_HUMAN
θ value	3.77169e-06 (rank : 10)	NC score	0.298104 (rank : 46)
Query Neighborhood Hits	168	Target Neighborhood Hits	2046	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

KPCA_HUMAN
θ value	8.40245e-06 (rank : 11)	NC score	0.125313 (rank : 113)
Query Neighborhood Hits	168	Target Neighborhood Hits	1070	Shared Neighborhood Hits	104
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT5_MOUSE
θ value	8.40245e-06 (rank : 12)	NC score	0.385214 (rank : 18)
Query Neighborhood Hits	168	Target Neighborhood Hits	140	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

ITSN2_MOUSE
θ value	1.43324e-05 (rank : 13)	NC score	0.168780 (rank : 101)
Query Neighborhood Hits	168	Target Neighborhood Hits	1371	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

KPCB_MOUSE
θ value	1.43324e-05 (rank : 14)	NC score	0.125570 (rank : 112)
Query Neighborhood Hits	168	Target Neighborhood Hits	1117	Shared Neighborhood Hits	102
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

SYT1_HUMAN
θ value	1.43324e-05 (rank : 15)	NC score	0.379065 (rank : 24)
Query Neighborhood Hits	168	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	1.43324e-05 (rank : 16)	NC score	0.379055 (rank : 25)
Query Neighborhood Hits	168	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT2_HUMAN
θ value	1.43324e-05 (rank : 17)	NC score	0.375491 (rank : 32)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
θ value	1.43324e-05 (rank : 18)	NC score	0.376389 (rank : 31)
Query Neighborhood Hits	168	Target Neighborhood Hits	143	Shared Neighborhood Hits	100
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_HUMAN
θ value	1.87187e-05 (rank : 19)	NC score	0.382311 (rank : 20)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	99
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT7_MOUSE
θ value	1.87187e-05 (rank : 20)	NC score	0.378612 (rank : 27)
Query Neighborhood Hits	168	Target Neighborhood Hits	137	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

KPCB_HUMAN
θ value	2.44474e-05 (rank : 21)	NC score	0.123939 (rank : 114)
Query Neighborhood Hits	168	Target Neighborhood Hits	1121	Shared Neighborhood Hits	102
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

SYT10_MOUSE
θ value	2.44474e-05 (rank : 22)	NC score	0.388495 (rank : 15)
Query Neighborhood Hits	168	Target Neighborhood Hits	133	Shared Neighborhood Hits	99
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

ITSN2_HUMAN
θ value	3.19293e-05 (rank : 23)	NC score	0.178937 (rank : 96)
Query Neighborhood Hits	168	Target Neighborhood Hits	1173	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

KPCA_MOUSE
θ value	3.19293e-05 (rank : 24)	NC score	0.123184 (rank : 116)
Query Neighborhood Hits	168	Target Neighborhood Hits	1067	Shared Neighborhood Hits	104
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT10_HUMAN
θ value	3.19293e-05 (rank : 25)	NC score	0.384672 (rank : 19)
Query Neighborhood Hits	168	Target Neighborhood Hits	134	Shared Neighborhood Hits	99
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

KPCG_HUMAN
θ value	4.1701e-05 (rank : 26)	NC score	0.131474 (rank : 111)
Query Neighborhood Hits	168	Target Neighborhood Hits	1126	Shared Neighborhood Hits	101
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	4.1701e-05 (rank : 27)	NC score	0.131632 (rank : 110)
Query Neighborhood Hits	168	Target Neighborhood Hits	1123	Shared Neighborhood Hits	101
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

SYT3_HUMAN
θ value	4.1701e-05 (rank : 28)	NC score	0.389132 (rank : 13)
Query Neighborhood Hits	168	Target Neighborhood Hits	145	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	4.1701e-05 (rank : 29)	NC score	0.389095 (rank : 14)
Query Neighborhood Hits	168	Target Neighborhood Hits	147	Shared Neighborhood Hits	96
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT9_HUMAN
θ value	7.1131e-05 (rank : 30)	NC score	0.381085 (rank : 21)
Query Neighborhood Hits	168	Target Neighborhood Hits	144	Shared Neighborhood Hits	99
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	7.1131e-05 (rank : 31)	NC score	0.380408 (rank : 23)
Query Neighborhood Hits	168	Target Neighborhood Hits	148	Shared Neighborhood Hits	99
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

DOC2A_MOUSE
θ value	0.000121331 (rank : 32)	NC score	0.393767 (rank : 9)
Query Neighborhood Hits	168	Target Neighborhood Hits	140	Shared Neighborhood Hits	101
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

RP3A_HUMAN
θ value	0.000121331 (rank : 33)	NC score	0.380847 (rank : 22)
Query Neighborhood Hits	168	Target Neighborhood Hits	305	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT6_HUMAN
θ value	0.000121331 (rank : 34)	NC score	0.377537 (rank : 28)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	99
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

PA24D_MOUSE
θ value	0.000158464 (rank : 35)	NC score	0.285157 (rank : 51)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RP3A_MOUSE
θ value	0.000158464 (rank : 36)	NC score	0.378885 (rank : 26)
Query Neighborhood Hits	168	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

FA62A_HUMAN
θ value	0.00020696 (rank : 37)	NC score	0.393212 (rank : 10)
Query Neighborhood Hits	168	Target Neighborhood Hits	168	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT6_MOUSE
θ value	0.00020696 (rank : 38)	NC score	0.377419 (rank : 30)
Query Neighborhood Hits	168	Target Neighborhood Hits	132	Shared Neighborhood Hits	99
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

DOC2A_HUMAN
θ value	0.000270298 (rank : 39)	NC score	0.390923 (rank : 12)
Query Neighborhood Hits	168	Target Neighborhood Hits	144	Shared Neighborhood Hits	100
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

SYT7_HUMAN
θ value	0.000270298 (rank : 40)	NC score	0.377502 (rank : 29)
Query Neighborhood Hits	168	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

UN13D_HUMAN
θ value	0.000270298 (rank : 41)	NC score	0.362078 (rank : 34)
Query Neighborhood Hits	168	Target Neighborhood Hits	117	Shared Neighborhood Hits	83
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

FA62A_MOUSE
θ value	0.000786445 (rank : 42)	NC score	0.392774 (rank : 11)
Query Neighborhood Hits	168	Target Neighborhood Hits	155	Shared Neighborhood Hits	102
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RFIP2_HUMAN
θ value	0.000786445 (rank : 43)	NC score	0.307746 (rank : 42)
Query Neighborhood Hits	168	Target Neighborhood Hits	97	Shared Neighborhood Hits	66
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

BAIP3_MOUSE
θ value	0.00102713 (rank : 44)	NC score	0.353637 (rank : 35)
Query Neighborhood Hits	168	Target Neighborhood Hits	112	Shared Neighborhood Hits	83
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_HUMAN
θ value	0.00134147 (rank : 45)	NC score	0.348957 (rank : 36)
Query Neighborhood Hits	168	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

DOC2B_MOUSE
θ value	0.00134147 (rank : 46)	NC score	0.386742 (rank : 16)
Query Neighborhood Hits	168	Target Neighborhood Hits	169	Shared Neighborhood Hits	101
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2G_MOUSE
θ value	0.00228821 (rank : 47)	NC score	0.367498 (rank : 33)
Query Neighborhood Hits	168	Target Neighborhood Hits	125	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

PA24D_HUMAN
θ value	0.00228821 (rank : 48)	NC score	0.238703 (rank : 64)
Query Neighborhood Hits	168	Target Neighborhood Hits	97	Shared Neighborhood Hits	80
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

SYTL2_MOUSE
θ value	0.00228821 (rank : 49)	NC score	0.308057 (rank : 41)
Query Neighborhood Hits	168	Target Neighborhood Hits	253	Shared Neighborhood Hits	83
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

UN13A_HUMAN
θ value	0.00228821 (rank : 50)	NC score	0.291287 (rank : 48)
Query Neighborhood Hits	168	Target Neighborhood Hits	285	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

DOC2B_HUMAN
θ value	0.00298849 (rank : 51)	NC score	0.385905 (rank : 17)
Query Neighborhood Hits	168	Target Neighborhood Hits	150	Shared Neighborhood Hits	101
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

CPNE3_MOUSE
θ value	0.00390308 (rank : 52)	NC score	0.240492 (rank : 62)
Query Neighborhood Hits	168	Target Neighborhood Hits	90	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

UN13B_MOUSE
θ value	0.00509761 (rank : 53)	NC score	0.287097 (rank : 49)
Query Neighborhood Hits	168	Target Neighborhood Hits	210	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYTL2_HUMAN
θ value	0.00869519 (rank : 54)	NC score	0.306229 (rank : 43)
Query Neighborhood Hits	168	Target Neighborhood Hits	248	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CPNE8_HUMAN
θ value	0.0113563 (rank : 55)	NC score	0.234695 (rank : 67)
Query Neighborhood Hits	168	Target Neighborhood Hits	86	Shared Neighborhood Hits	77
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE8_MOUSE
θ value	0.0113563 (rank : 56)	NC score	0.231810 (rank : 69)
Query Neighborhood Hits	168	Target Neighborhood Hits	85	Shared Neighborhood Hits	77
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

ITSN1_HUMAN
θ value	0.0148317 (rank : 57)	NC score	0.122433 (rank : 117)
Query Neighborhood Hits	168	Target Neighborhood Hits	1757	Shared Neighborhood Hits	111
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.0148317 (rank : 58)	NC score	0.123636 (rank : 115)
Query Neighborhood Hits	168	Target Neighborhood Hits	1669	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NEDD4_HUMAN
θ value	0.0148317 (rank : 59)	NC score	0.198096 (rank : 83)
Query Neighborhood Hits	168	Target Neighborhood Hits	214	Shared Neighborhood Hits	97
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

CPNE3_HUMAN
θ value	0.0193708 (rank : 60)	NC score	0.235104 (rank : 66)
Query Neighborhood Hits	168	Target Neighborhood Hits	90	Shared Neighborhood Hits	81
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE5_HUMAN
θ value	0.0193708 (rank : 61)	NC score	0.231352 (rank : 71)
Query Neighborhood Hits	168	Target Neighborhood Hits	88	Shared Neighborhood Hits	77
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	0.0193708 (rank : 62)	NC score	0.231496 (rank : 70)
Query Neighborhood Hits	168	Target Neighborhood Hits	86	Shared Neighborhood Hits	77
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE7_HUMAN
θ value	0.0193708 (rank : 63)	NC score	0.214518 (rank : 75)
Query Neighborhood Hits	168	Target Neighborhood Hits	92	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

PERF_MOUSE
θ value	0.0193708 (rank : 64)	NC score	0.157301 (rank : 104)
Query Neighborhood Hits	168	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

SYTL5_MOUSE
θ value	0.0193708 (rank : 65)	NC score	0.292960 (rank : 47)
Query Neighborhood Hits	168	Target Neighborhood Hits	154	Shared Neighborhood Hits	89
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

PA24F_HUMAN
θ value	0.0330416 (rank : 66)	NC score	0.163554 (rank : 103)
Query Neighborhood Hits	168	Target Neighborhood Hits	78	Shared Neighborhood Hits	62
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

RASA2_MOUSE
θ value	0.0330416 (rank : 67)	NC score	0.227460 (rank : 72)
Query Neighborhood Hits	168	Target Neighborhood Hits	159	Shared Neighborhood Hits	71
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

PERF_HUMAN
θ value	0.0431538 (rank : 68)	NC score	0.143017 (rank : 107)
Query Neighborhood Hits	168	Target Neighborhood Hits	48	Shared Neighborhood Hits	26
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

NEDD4_MOUSE
θ value	0.0563607 (rank : 69)	NC score	0.195574 (rank : 87)
Query Neighborhood Hits	168	Target Neighborhood Hits	212	Shared Neighborhood Hits	98
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

CPNE4_HUMAN
θ value	0.0736092 (rank : 70)	NC score	0.179246 (rank : 95)
Query Neighborhood Hits	168	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	0.0736092 (rank : 71)	NC score	0.178644 (rank : 98)
Query Neighborhood Hits	168	Target Neighborhood Hits	67	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE6_HUMAN
θ value	0.0736092 (rank : 72)	NC score	0.198711 (rank : 81)
Query Neighborhood Hits	168	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
θ value	0.0736092 (rank : 73)	NC score	0.195893 (rank : 84)
Query Neighborhood Hits	168	Target Neighborhood Hits	87	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

PA24B_MOUSE
θ value	0.0736092 (rank : 74)	NC score	0.236984 (rank : 65)
Query Neighborhood Hits	168	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

LRRF1_MOUSE
θ value	0.125558 (rank : 75)	NC score	0.033729 (rank : 145)
Query Neighborhood Hits	168	Target Neighborhood Hits	440	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

K0528_HUMAN
θ value	0.163984 (rank : 76)	NC score	0.302927 (rank : 44)
Query Neighborhood Hits	168	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	0.163984 (rank : 77)	NC score	0.302547 (rank : 45)
Query Neighborhood Hits	168	Target Neighborhood Hits	102	Shared Neighborhood Hits	69
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

SYTL5_HUMAN
θ value	0.163984 (rank : 78)	NC score	0.285775 (rank : 50)
Query Neighborhood Hits	168	Target Neighborhood Hits	237	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

PA24A_HUMAN
θ value	0.21417 (rank : 79)	NC score	0.195358 (rank : 88)
Query Neighborhood Hits	168	Target Neighborhood Hits	88	Shared Neighborhood Hits	69
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24A_MOUSE
θ value	0.21417 (rank : 80)	NC score	0.200361 (rank : 80)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24E_HUMAN
θ value	0.21417 (rank : 81)	NC score	0.187938 (rank : 93)
Query Neighborhood Hits	168	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

RASA1_HUMAN
θ value	0.21417 (rank : 82)	NC score	0.083997 (rank : 130)
Query Neighborhood Hits	168	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASA2_HUMAN
θ value	0.279714 (rank : 83)	NC score	0.210622 (rank : 77)
Query Neighborhood Hits	168	Target Neighborhood Hits	157	Shared Neighborhood Hits	68
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SMUF2_HUMAN
θ value	0.365318 (rank : 84)	NC score	0.102060 (rank : 126)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SYT11_HUMAN
θ value	0.365318 (rank : 85)	NC score	0.315313 (rank : 38)
Query Neighborhood Hits	168	Target Neighborhood Hits	113	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	0.365318 (rank : 86)	NC score	0.316916 (rank : 37)
Query Neighborhood Hits	168	Target Neighborhood Hits	116	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

ARP2_HUMAN
θ value	0.47712 (rank : 87)	NC score	0.019629 (rank : 160)
Query Neighborhood Hits	168	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	P61160, O15142, Q96C82	Gene names	ACTR2, ARP2
Domain Architecture
Description	Actin-like protein 2 (Actin-related protein 2).

ARP2_MOUSE
θ value	0.47712 (rank : 88)	NC score	0.019629 (rank : 161)
Query Neighborhood Hits	168	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	P61161, O15142	Gene names	Actr2, Arp2
Domain Architecture
Description	Actin-like protein 2 (Actin-related protein 2).

CDC5L_MOUSE
θ value	0.47712 (rank : 89)	NC score	0.050144 (rank : 139)
Query Neighborhood Hits	168	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q6A068, Q8K1J9	Gene names	Cdc5l, Kiaa0432
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-related protein (Cdc5-like protein).

RUFY3_HUMAN
θ value	0.62314 (rank : 90)	NC score	0.024869 (rank : 152)
Query Neighborhood Hits	168	Target Neighborhood Hits	594	Shared Neighborhood Hits	21
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

NIPBL_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.028662 (rank : 148)
Query Neighborhood Hits	168	Target Neighborhood Hits	1311	Shared Neighborhood Hits	29
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

SMUF1_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.100514 (rank : 127)
Query Neighborhood Hits	168	Target Neighborhood Hits	135	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	0.813845 (rank : 93)	NC score	0.099648 (rank : 128)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	68
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

UN13B_HUMAN
θ value	0.813845 (rank : 94)	NC score	0.263855 (rank : 56)
Query Neighborhood Hits	168	Target Neighborhood Hits	217	Shared Neighborhood Hits	100
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CDC5L_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.043588 (rank : 141)
Query Neighborhood Hits	168	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q99459, Q76N46, Q99974	Gene names	CDC5L, KIAA0432, PCDC5RP
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5- related protein).

GOGB1_HUMAN
θ value	1.06291 (rank : 96)	NC score	0.017642 (rank : 166)
Query Neighborhood Hits	168	Target Neighborhood Hits	2297	Shared Neighborhood Hits	42
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

LACTB_MOUSE
θ value	1.06291 (rank : 97)	NC score	0.042376 (rank : 142)
Query Neighborhood Hits	168	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EP89	Gene names	Lactb, Lact1
Domain Architecture
Description	Serine beta-lactamase-like protein LACTB.

RUFY3_MOUSE
θ value	1.06291 (rank : 98)	NC score	0.024246 (rank : 154)
Query Neighborhood Hits	168	Target Neighborhood Hits	579	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

K1196_HUMAN
θ value	1.38821 (rank : 99)	NC score	0.017233 (rank : 167)
Query Neighborhood Hits	168	Target Neighborhood Hits	618	Shared Neighborhood Hits	5
SwissProt Accessions	Q96KM6, Q9ULM4	Gene names	KIAA1196
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1196.

SYT4_MOUSE
θ value	1.38821 (rank : 100)	NC score	0.315224 (rank : 39)
Query Neighborhood Hits	168	Target Neighborhood Hits	123	Shared Neighborhood Hits	87
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

CPNE1_MOUSE
θ value	2.36792 (rank : 101)	NC score	0.203704 (rank : 79)
Query Neighborhood Hits	168	Target Neighborhood Hits	83	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE2_MOUSE
θ value	2.36792 (rank : 102)	NC score	0.210782 (rank : 76)
Query Neighborhood Hits	168	Target Neighborhood Hits	82	Shared Neighborhood Hits	72
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

HIC2_MOUSE
θ value	2.36792 (rank : 103)	NC score	-0.003144 (rank : 203)
Query Neighborhood Hits	168	Target Neighborhood Hits	821	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLZ6, Q3U030, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5	Gene names	Hic2, Kiaa1020
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2).

MDN1_HUMAN
θ value	2.36792 (rank : 104)	NC score	0.038908 (rank : 143)
Query Neighborhood Hits	168	Target Neighborhood Hits	662	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

MY18A_HUMAN
θ value	2.36792 (rank : 105)	NC score	0.015109 (rank : 173)
Query Neighborhood Hits	168	Target Neighborhood Hits	1929	Shared Neighborhood Hits	39
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

ANGL4_HUMAN
θ value	3.0926 (rank : 106)	NC score	0.012845 (rank : 181)
Query Neighborhood Hits	168	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BY76, Q53HQ6, Q53HU1, Q6UXN0, Q9HBV4, Q9NZU4, Q9Y5B3	Gene names	ANGPTL4, ARP4, HFARP, PGAR
Domain Architecture
Description	Angiopoietin-related protein 4 precursor (Angiopoietin-like 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP).

CPNE2_HUMAN
θ value	3.0926 (rank : 107)	NC score	0.204466 (rank : 78)
Query Neighborhood Hits	168	Target Neighborhood Hits	75	Shared Neighborhood Hits	69
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

PA24B_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.168587 (rank : 102)
Query Neighborhood Hits	168	Target Neighborhood Hits	89	Shared Neighborhood Hits	69
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PTPRT_HUMAN
θ value	3.0926 (rank : 109)	NC score	0.005329 (rank : 193)
Query Neighborhood Hits	168	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	3.0926 (rank : 110)	NC score	0.005244 (rank : 194)
Query Neighborhood Hits	168	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

CCHCR_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.018196 (rank : 164)
Query Neighborhood Hits	168	Target Neighborhood Hits	717	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CDT1_MOUSE
θ value	4.03905 (rank : 112)	NC score	0.028312 (rank : 149)
Query Neighborhood Hits	168	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

CE005_MOUSE
θ value	4.03905 (rank : 113)	NC score	0.010867 (rank : 186)
Query Neighborhood Hits	168	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CE290_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.013726 (rank : 178)
Query Neighborhood Hits	168	Target Neighborhood Hits	1553	Shared Neighborhood Hits	33
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CF010_HUMAN
θ value	4.03905 (rank : 115)	NC score	0.016925 (rank : 168)
Query Neighborhood Hits	168	Target Neighborhood Hits	329	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SRN2, Q5SPI9, Q5SPJ0, Q5SPK9, Q5SPL0, Q5SRN3, Q5TG25, Q5TG26, Q8N4B6	Gene names	C6orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf10.

CTRO_MOUSE
θ value	4.03905 (rank : 116)	NC score	0.020868 (rank : 157)
Query Neighborhood Hits	168	Target Neighborhood Hits	2344	Shared Neighborhood Hits	48
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

GON4L_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.015569 (rank : 170)
Query Neighborhood Hits	168	Target Neighborhood Hits	555	Shared Neighborhood Hits	17
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

ITCH_HUMAN
θ value	4.03905 (rank : 118)	NC score	0.047339 (rank : 140)
Query Neighborhood Hits	168	Target Neighborhood Hits	162	Shared Neighborhood Hits	28
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NED4L_HUMAN
θ value	4.03905 (rank : 119)	NC score	0.198529 (rank : 82)
Query Neighborhood Hits	168	Target Neighborhood Hits	238	Shared Neighborhood Hits	100
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	4.03905 (rank : 120)	NC score	0.195796 (rank : 85)
Query Neighborhood Hits	168	Target Neighborhood Hits	231	Shared Neighborhood Hits	100
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NP1L4_MOUSE
θ value	4.03905 (rank : 121)	NC score	0.015569 (rank : 171)
Query Neighborhood Hits	168	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q78ZA7, O88701	Gene names	Nap1l4
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 4.

PA24E_MOUSE
θ value	4.03905 (rank : 122)	NC score	0.178692 (rank : 97)
Query Neighborhood Hits	168	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PIR_HUMAN
θ value	4.03905 (rank : 123)	NC score	0.027168 (rank : 150)
Query Neighborhood Hits	168	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O00625, Q5U0G0	Gene names	PIR
Domain Architecture
Description	Pirin.

RGNEF_MOUSE
θ value	4.03905 (rank : 124)	NC score	0.038221 (rank : 144)
Query Neighborhood Hits	168	Target Neighborhood Hits	641	Shared Neighborhood Hits	31
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SI1L1_HUMAN
θ value	4.03905 (rank : 125)	NC score	0.012035 (rank : 184)
Query Neighborhood Hits	168	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	4.03905 (rank : 126)	NC score	0.011770 (rank : 185)
Query Neighborhood Hits	168	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SPRL1_MOUSE
θ value	4.03905 (rank : 127)	NC score	0.015643 (rank : 169)
Query Neighborhood Hits	168	Target Neighborhood Hits	403	Shared Neighborhood Hits	16
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

SYT8_MOUSE
θ value	4.03905 (rank : 128)	NC score	0.265966 (rank : 54)
Query Neighborhood Hits	168	Target Neighborhood Hits	94	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

TCTP_MOUSE
θ value	4.03905 (rank : 129)	NC score	0.019509 (rank : 162)
Query Neighborhood Hits	168	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P63028, P14701, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9	Gene names	Tpt1, Trt
Domain Architecture	No domain graphic available
Description	Translationally-controlled tumor protein (TCTP) (p23) (21 kDa polypeptide) (p21).

TXLNB_HUMAN
θ value	4.03905 (rank : 130)	NC score	0.019744 (rank : 159)
Query Neighborhood Hits	168	Target Neighborhood Hits	912	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

WWP1_MOUSE
θ value	4.03905 (rank : 131)	NC score	0.050757 (rank : 138)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

AKA12_HUMAN
θ value	5.27518 (rank : 132)	NC score	0.026685 (rank : 151)
Query Neighborhood Hits	168	Target Neighborhood Hits	825	Shared Neighborhood Hits	25
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

CT102_MOUSE
θ value	5.27518 (rank : 133)	NC score	0.030285 (rank : 146)
Query Neighborhood Hits	168	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDS0	Gene names	Gm691
Domain Architecture	No domain graphic available
Description	Protein C20orf102 homolog precursor.

DLX2_MOUSE
θ value	5.27518 (rank : 134)	NC score	0.003640 (rank : 197)
Query Neighborhood Hits	168	Target Neighborhood Hits	352	Shared Neighborhood Hits	3
SwissProt Accessions	P40764	Gene names	Dlx2, Tes-1, Tes1
Domain Architecture
Description	Homeobox protein DLX-2 (Homeobox protein TES-1).

FATH_HUMAN
θ value	5.27518 (rank : 135)	NC score	0.000383 (rank : 201)
Query Neighborhood Hits	168	Target Neighborhood Hits	570	Shared Neighborhood Hits	7
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

HDGR3_HUMAN
θ value	5.27518 (rank : 136)	NC score	0.014736 (rank : 176)
Query Neighborhood Hits	168	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

HDGR3_MOUSE
θ value	5.27518 (rank : 137)	NC score	0.014801 (rank : 174)
Query Neighborhood Hits	168	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMG7, Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7	Gene names	Hdgfrp3
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3).

HOOK2_MOUSE
θ value	5.27518 (rank : 138)	NC score	0.014749 (rank : 175)
Query Neighborhood Hits	168	Target Neighborhood Hits	736	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

P3C2B_HUMAN
θ value	5.27518 (rank : 139)	NC score	0.153717 (rank : 105)
Query Neighborhood Hits	168	Target Neighborhood Hits	148	Shared Neighborhood Hits	63
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PCDA5_HUMAN
θ value	5.27518 (rank : 140)	NC score	0.000548 (rank : 200)
Query Neighborhood Hits	168	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

STK10_HUMAN
θ value	5.27518 (rank : 141)	NC score	0.012550 (rank : 183)
Query Neighborhood Hits	168	Target Neighborhood Hits	1921	Shared Neighborhood Hits	34
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TCTP_HUMAN
θ value	5.27518 (rank : 142)	NC score	0.018065 (rank : 165)
Query Neighborhood Hits	168	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P13693, Q6YLS2, Q7Z4J4, Q96EE2, Q9UC70	Gene names	TPT1
Domain Architecture
Description	Translationally-controlled tumor protein (TCTP) (p23) (Histamine- releasing factor) (HRF) (Fortilin).

ACINU_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.029195 (rank : 147)
Query Neighborhood Hits	168	Target Neighborhood Hits	828	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ADIP_MOUSE
θ value	6.88961 (rank : 144)	NC score	0.020139 (rank : 158)
Query Neighborhood Hits	168	Target Neighborhood Hits	415	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

BTBD3_HUMAN
θ value	6.88961 (rank : 145)	NC score	0.006181 (rank : 192)
Query Neighborhood Hits	168	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2F9	Gene names	BTBD3, KIAA0952
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

BTBD3_MOUSE
θ value	6.88961 (rank : 146)	NC score	0.006191 (rank : 191)
Query Neighborhood Hits	168	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	P58545	Gene names	Btbd3
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

CP250_MOUSE
θ value	6.88961 (rank : 147)	NC score	0.015463 (rank : 172)
Query Neighborhood Hits	168	Target Neighborhood Hits	1583	Shared Neighborhood Hits	34
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CPNE1_HUMAN
θ value	6.88961 (rank : 148)	NC score	0.184278 (rank : 94)
Query Neighborhood Hits	168	Target Neighborhood Hits	70	Shared Neighborhood Hits	69
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

EYA1_MOUSE
θ value	6.88961 (rank : 149)	NC score	0.009321 (rank : 187)
Query Neighborhood Hits	168	Target Neighborhood Hits	108	Shared Neighborhood Hits	3
SwissProt Accessions	P97767, O08818	Gene names	Eya1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

HS105_HUMAN
θ value	6.88961 (rank : 150)	NC score	0.005183 (rank : 196)
Query Neighborhood Hits	168	Target Neighborhood Hits	209	Shared Neighborhood Hits	10
SwissProt Accessions	Q92598, O95739, Q5TBM6, Q5TBM8, Q9UPC4	Gene names	HSPH1, HSP105, HSP110, KIAA0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY- CO-25).

K0841_HUMAN
θ value	6.88961 (rank : 151)	NC score	0.020924 (rank : 156)
Query Neighborhood Hits	168	Target Neighborhood Hits	119	Shared Neighborhood Hits	8
SwissProt Accessions	O94927, Q6P2P7, Q7L3D5, Q96CT8	Gene names	KIAA0841
Domain Architecture	No domain graphic available
Description	Protein KIAA0841.

MYH9_HUMAN
θ value	6.88961 (rank : 152)	NC score	0.008073 (rank : 189)
Query Neighborhood Hits	168	Target Neighborhood Hits	1762	Shared Neighborhood Hits	35
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	6.88961 (rank : 153)	NC score	0.008661 (rank : 188)
Query Neighborhood Hits	168	Target Neighborhood Hits	1829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RAD50_MOUSE
θ value	6.88961 (rank : 154)	NC score	0.013125 (rank : 179)
Query Neighborhood Hits	168	Target Neighborhood Hits	1366	Shared Neighborhood Hits	35
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

SNUT1_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.024820 (rank : 153)
Query Neighborhood Hits	168	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

TDRD1_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.014180 (rank : 177)
Query Neighborhood Hits	168	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MV1	Gene names	Tdrd1
Domain Architecture
Description	Tudor domain-containing protein 1.

TRI66_MOUSE
θ value	6.88961 (rank : 157)	NC score	0.012849 (rank : 180)
Query Neighborhood Hits	168	Target Neighborhood Hits	491	Shared Neighborhood Hits	14
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

AFAD_HUMAN
θ value	8.99809 (rank : 158)	NC score	0.012610 (rank : 182)
Query Neighborhood Hits	168	Target Neighborhood Hits	689	Shared Neighborhood Hits	22
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

INHBE_HUMAN
θ value	8.99809 (rank : 159)	NC score	0.002893 (rank : 198)
Query Neighborhood Hits	168	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P58166	Gene names	INHBE
Domain Architecture
Description	Inhibin beta E chain precursor (Activin beta-E chain).

MYH13_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.007098 (rank : 190)
Query Neighborhood Hits	168	Target Neighborhood Hits	1504	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PER2_MOUSE
θ value	8.99809 (rank : 161)	NC score	0.005196 (rank : 195)
Query Neighborhood Hits	168	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PHLPL_HUMAN
θ value	8.99809 (rank : 162)	NC score	0.000563 (rank : 199)
Query Neighborhood Hits	168	Target Neighborhood Hits	310	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

RLF_HUMAN
θ value	8.99809 (rank : 163)	NC score	-0.000709 (rank : 202)
Query Neighborhood Hits	168	Target Neighborhood Hits	775	Shared Neighborhood Hits	7
SwissProt Accessions	Q13129, Q9NU60	Gene names	RLF
Domain Architecture	No domain graphic available
Description	Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15- related protein).

SAFB2_MOUSE
θ value	8.99809 (rank : 164)	NC score	0.018882 (rank : 163)
Query Neighborhood Hits	168	Target Neighborhood Hits	581	Shared Neighborhood Hits	23
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

SYT12_HUMAN
θ value	8.99809 (rank : 165)	NC score	0.258626 (rank : 59)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	66
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT12_MOUSE
θ value	8.99809 (rank : 166)	NC score	0.265933 (rank : 55)
Query Neighborhood Hits	168	Target Neighborhood Hits	102	Shared Neighborhood Hits	69
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT4_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.313309 (rank : 40)
Query Neighborhood Hits	168	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

TCRG1_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.021557 (rank : 155)
Query Neighborhood Hits	168	Target Neighborhood Hits	947	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

DAB2P_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.053005 (rank : 135)
Query Neighborhood Hits	168	Target Neighborhood Hits	303	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAB2P_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.051192 (rank : 137)
Query Neighborhood Hits	168	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

P3C2A_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.118102 (rank : 118)
Query Neighborhood Hits	168	Target Neighborhood Hits	188	Shared Neighborhood Hits	60
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.117026 (rank : 119)
Query Neighborhood Hits	168	Target Neighborhood Hits	181	Shared Neighborhood Hits	57
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

PA24C_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.063106 (rank : 133)
Query Neighborhood Hits	168	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UP65, O75457, Q9UG68	Gene names	PLA2G4C
Domain Architecture
Description	Cytosolic phospholipase A2 gamma precursor (EC 3.1.1.4) (cPLA2-gamma) (Phospholipase A2 group IVC).

PA24F_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.147410 (rank : 106)
Query Neighborhood Hits	168	Target Neighborhood Hits	93	Shared Neighborhood Hits	68
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PLCD1_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.092895 (rank : 129)
Query Neighborhood Hits	168	Target Neighborhood Hits	93	Shared Neighborhood Hits	54
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.069899 (rank : 132)
Query Neighborhood Hits	168	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

RASA3_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.193787 (rank : 89)
Query Neighborhood Hits	168	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA3_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.174005 (rank : 100)
Query Neighborhood Hits	168	Target Neighborhood Hits	144	Shared Neighborhood Hits	64
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RFIP1_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.116182 (rank : 120)
Query Neighborhood Hits	168	Target Neighborhood Hits	236	Shared Neighborhood Hits	36
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RFIP1_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.110776 (rank : 121)
Query Neighborhood Hits	168	Target Neighborhood Hits	152	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RGS3_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.075646 (rank : 131)
Query Neighborhood Hits	168	Target Neighborhood Hits	1375	Shared Neighborhood Hits	59
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RIMS1_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.178038 (rank : 99)
Query Neighborhood Hits	168	Target Neighborhood Hits	437	Shared Neighborhood Hits	79
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.191208 (rank : 91)
Query Neighborhood Hits	168	Target Neighborhood Hits	342	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.189574 (rank : 92)
Query Neighborhood Hits	168	Target Neighborhood Hits	376	Shared Neighborhood Hits	88
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS3_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.105819 (rank : 124)
Query Neighborhood Hits	168	Target Neighborhood Hits	66	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.102562 (rank : 125)
Query Neighborhood Hits	168	Target Neighborhood Hits	67	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.137516 (rank : 109)
Query Neighborhood Hits	168	Target Neighborhood Hits	76	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.138878 (rank : 108)
Query Neighborhood Hits	168	Target Neighborhood Hits	76	Shared Neighborhood Hits	53
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYGP1_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.051995 (rank : 136)
Query Neighborhood Hits	168	Target Neighborhood Hits	589	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

SYT13_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.226304 (rank : 73)
Query Neighborhood Hits	168	Target Neighborhood Hits	76	Shared Neighborhood Hits	56
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.217487 (rank : 74)
Query Neighborhood Hits	168	Target Neighborhood Hits	69	Shared Neighborhood Hits	53
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.193443 (rank : 90)
Query Neighborhood Hits	168	Target Neighborhood Hits	81	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.195745 (rank : 86)
Query Neighborhood Hits	168	Target Neighborhood Hits	82	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT15_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.249512 (rank : 61)
Query Neighborhood Hits	168	Target Neighborhood Hits	112	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT15_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.240287 (rank : 63)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	69
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYTL1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.271959 (rank : 53)
Query Neighborhood Hits	168	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.251433 (rank : 60)
Query Neighborhood Hits	168	Target Neighborhood Hits	314	Shared Neighborhood Hits	73
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL3_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.232039 (rank : 68)
Query Neighborhood Hits	168	Target Neighborhood Hits	110	Shared Neighborhood Hits	60
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.260932 (rank : 58)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	71
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.261904 (rank : 57)
Query Neighborhood Hits	168	Target Neighborhood Hits	137	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TAC2N_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.108753 (rank : 122)
Query Neighborhood Hits	168	Target Neighborhood Hits	47	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.105879 (rank : 123)
Query Neighborhood Hits	168	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

WWC1_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.056740 (rank : 134)
Query Neighborhood Hits	168	Target Neighborhood Hits	290	Shared Neighborhood Hits	46
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

Hits sorted by NC score

OTOF_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	168	Target Neighborhood Hits	168	Shared Neighborhood Hits	168
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
NC score	0.993605 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	168	Target Neighborhood Hits	196	Shared Neighborhood Hits	137
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

MYOF_HUMAN
NC score	0.920959 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	168	Target Neighborhood Hits	147	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

DYSF_HUMAN
NC score	0.916488 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	168	Target Neighborhood Hits	170	Shared Neighborhood Hits	102
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

DYSF_MOUSE
NC score	0.912931 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	168	Target Neighborhood Hits	162	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

RASL1_HUMAN
NC score	0.441897 (rank : 6)	θ value	2.28291e-11 (rank : 6)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	97
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
NC score	0.427255 (rank : 7)	θ value	3.29651e-10 (rank : 7)
Query Neighborhood Hits	168	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
NC score	0.414013 (rank : 8)	θ value	2.61198e-07 (rank : 9)
Query Neighborhood Hits	168	Target Neighborhood Hits	161	Shared Neighborhood Hits	99
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

DOC2A_MOUSE
NC score	0.393767 (rank : 9)	θ value	0.000121331 (rank : 32)
Query Neighborhood Hits	168	Target Neighborhood Hits	140	Shared Neighborhood Hits	101
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

FA62A_HUMAN
NC score	0.393212 (rank : 10)	θ value	0.00020696 (rank : 37)
Query Neighborhood Hits	168	Target Neighborhood Hits	168	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
NC score	0.392774 (rank : 11)	θ value	0.000786445 (rank : 42)
Query Neighborhood Hits	168	Target Neighborhood Hits	155	Shared Neighborhood Hits	102
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

DOC2A_HUMAN
NC score	0.390923 (rank : 12)	θ value	0.000270298 (rank : 39)
Query Neighborhood Hits	168	Target Neighborhood Hits	144	Shared Neighborhood Hits	100
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

SYT3_HUMAN
NC score	0.389132 (rank : 13)	θ value	4.1701e-05 (rank : 28)
Query Neighborhood Hits	168	Target Neighborhood Hits	145	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
NC score	0.389095 (rank : 14)	θ value	4.1701e-05 (rank : 29)
Query Neighborhood Hits	168	Target Neighborhood Hits	147	Shared Neighborhood Hits	96
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT10_MOUSE
NC score	0.388495 (rank : 15)	θ value	2.44474e-05 (rank : 22)
Query Neighborhood Hits	168	Target Neighborhood Hits	133	Shared Neighborhood Hits	99
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2B_MOUSE
NC score	0.386742 (rank : 16)	θ value	0.00134147 (rank : 46)
Query Neighborhood Hits	168	Target Neighborhood Hits	169	Shared Neighborhood Hits	101
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_HUMAN
NC score	0.385905 (rank : 17)	θ value	0.00298849 (rank : 51)
Query Neighborhood Hits	168	Target Neighborhood Hits	150	Shared Neighborhood Hits	101
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

SYT5_MOUSE
NC score	0.385214 (rank : 18)	θ value	8.40245e-06 (rank : 12)
Query Neighborhood Hits	168	Target Neighborhood Hits	140	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT10_HUMAN
NC score	0.384672 (rank : 19)	θ value	3.19293e-05 (rank : 25)
Query Neighborhood Hits	168	Target Neighborhood Hits	134	Shared Neighborhood Hits	99
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT5_HUMAN
NC score	0.382311 (rank : 20)	θ value	1.87187e-05 (rank : 19)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	99
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT9_HUMAN
NC score	0.381085 (rank : 21)	θ value	7.1131e-05 (rank : 30)
Query Neighborhood Hits	168	Target Neighborhood Hits	144	Shared Neighborhood Hits	99
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

RP3A_HUMAN
NC score	0.380847 (rank : 22)	θ value	0.000121331 (rank : 33)
Query Neighborhood Hits	168	Target Neighborhood Hits	305	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT9_MOUSE
NC score	0.380408 (rank : 23)	θ value	7.1131e-05 (rank : 31)
Query Neighborhood Hits	168	Target Neighborhood Hits	148	Shared Neighborhood Hits	99
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT1_HUMAN
NC score	0.379065 (rank : 24)	θ value	1.43324e-05 (rank : 15)
Query Neighborhood Hits	168	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.379055 (rank : 25)	θ value	1.43324e-05 (rank : 16)
Query Neighborhood Hits	168	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

RP3A_MOUSE
NC score	0.378885 (rank : 26)	θ value	0.000158464 (rank : 36)
Query Neighborhood Hits	168	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT7_MOUSE
NC score	0.378612 (rank : 27)	θ value	1.87187e-05 (rank : 20)
Query Neighborhood Hits	168	Target Neighborhood Hits	137	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT6_HUMAN
NC score	0.377537 (rank : 28)	θ value	0.000121331 (rank : 34)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	99
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT7_HUMAN
NC score	0.377502 (rank : 29)	θ value	0.000270298 (rank : 40)
Query Neighborhood Hits	168	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT6_MOUSE
NC score	0.377419 (rank : 30)	θ value	0.00020696 (rank : 38)
Query Neighborhood Hits	168	Target Neighborhood Hits	132	Shared Neighborhood Hits	99
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT2_MOUSE
NC score	0.376389 (rank : 31)	θ value	1.43324e-05 (rank : 18)
Query Neighborhood Hits	168	Target Neighborhood Hits	143	Shared Neighborhood Hits	100
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.375491 (rank : 32)	θ value	1.43324e-05 (rank : 17)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

DOC2G_MOUSE
NC score	0.367498 (rank : 33)	θ value	0.00228821 (rank : 47)
Query Neighborhood Hits	168	Target Neighborhood Hits	125	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

UN13D_HUMAN
NC score	0.362078 (rank : 34)	θ value	0.000270298 (rank : 41)
Query Neighborhood Hits	168	Target Neighborhood Hits	117	Shared Neighborhood Hits	83
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

BAIP3_MOUSE
NC score	0.353637 (rank : 35)	θ value	0.00102713 (rank : 44)
Query Neighborhood Hits	168	Target Neighborhood Hits	112	Shared Neighborhood Hits	83
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_HUMAN
NC score	0.348957 (rank : 36)	θ value	0.00134147 (rank : 45)
Query Neighborhood Hits	168	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

SYT11_MOUSE
NC score	0.316916 (rank : 37)	θ value	0.365318 (rank : 86)
Query Neighborhood Hits	168	Target Neighborhood Hits	116	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.315313 (rank : 38)	θ value	0.365318 (rank : 85)
Query Neighborhood Hits	168	Target Neighborhood Hits	113	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT4_MOUSE
NC score	0.315224 (rank : 39)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	168	Target Neighborhood Hits	123	Shared Neighborhood Hits	87
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT4_HUMAN
NC score	0.313309 (rank : 40)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	168	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYTL2_MOUSE
NC score	0.308057 (rank : 41)	θ value	0.00228821 (rank : 49)
Query Neighborhood Hits	168	Target Neighborhood Hits	253	Shared Neighborhood Hits	83
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

RFIP2_HUMAN
NC score	0.307746 (rank : 42)	θ value	0.000786445 (rank : 43)
Query Neighborhood Hits	168	Target Neighborhood Hits	97	Shared Neighborhood Hits	66
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

SYTL2_HUMAN
NC score	0.306229 (rank : 43)	θ value	0.00869519 (rank : 54)
Query Neighborhood Hits	168	Target Neighborhood Hits	248	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

K0528_HUMAN
NC score	0.302927 (rank : 44)	θ value	0.163984 (rank : 76)
Query Neighborhood Hits	168	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
NC score	0.302547 (rank : 45)	θ value	0.163984 (rank : 77)
Query Neighborhood Hits	168	Target Neighborhood Hits	102	Shared Neighborhood Hits	69
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

PCLO_HUMAN
NC score	0.298104 (rank : 46)	θ value	3.77169e-06 (rank : 10)
Query Neighborhood Hits	168	Target Neighborhood Hits	2046	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYTL5_MOUSE
NC score	0.292960 (rank : 47)	θ value	0.0193708 (rank : 65)
Query Neighborhood Hits	168	Target Neighborhood Hits	154	Shared Neighborhood Hits	89
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

UN13A_HUMAN
NC score	0.291287 (rank : 48)	θ value	0.00228821 (rank : 50)
Query Neighborhood Hits	168	Target Neighborhood Hits	285	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_MOUSE
NC score	0.287097 (rank : 49)	θ value	0.00509761 (rank : 53)
Query Neighborhood Hits	168	Target Neighborhood Hits	210	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYTL5_HUMAN
NC score	0.285775 (rank : 50)	θ value	0.163984 (rank : 78)
Query Neighborhood Hits	168	Target Neighborhood Hits	237	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

PA24D_MOUSE
NC score	0.285157 (rank : 51)	θ value	0.000158464 (rank : 35)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PCLO_MOUSE
NC score	0.283964 (rank : 52)	θ value	6.87365e-08 (rank : 8)
Query Neighborhood Hits	168	Target Neighborhood Hits	2275	Shared Neighborhood Hits	120
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYTL1_HUMAN
NC score	0.271959 (rank : 53)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	168	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYT8_MOUSE
NC score	0.265966 (rank : 54)	θ value	4.03905 (rank : 128)
Query Neighborhood Hits	168	Target Neighborhood Hits	94	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT12_MOUSE
NC score	0.265933 (rank : 55)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	168	Target Neighborhood Hits	102	Shared Neighborhood Hits	69
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

UN13B_HUMAN
NC score	0.263855 (rank : 56)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	168	Target Neighborhood Hits	217	Shared Neighborhood Hits	100
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYTL4_MOUSE
NC score	0.261904 (rank : 57)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	168	Target Neighborhood Hits	137	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_HUMAN
NC score	0.260932 (rank : 58)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	71
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYT12_HUMAN
NC score	0.258626 (rank : 59)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	66
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYTL1_MOUSE
NC score	0.251433 (rank : 60)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	168	Target Neighborhood Hits	314	Shared Neighborhood Hits	73
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYT15_HUMAN
NC score	0.249512 (rank : 61)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	168	Target Neighborhood Hits	112	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

CPNE3_MOUSE
NC score	0.240492 (rank : 62)	θ value	0.00390308 (rank : 52)
Query Neighborhood Hits	168	Target Neighborhood Hits	90	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

SYT15_MOUSE
NC score	0.240287 (rank : 63)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	69
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

PA24D_HUMAN
NC score	0.238703 (rank : 64)	θ value	0.00228821 (rank : 48)
Query Neighborhood Hits	168	Target Neighborhood Hits	97	Shared Neighborhood Hits	80
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PA24B_MOUSE
NC score	0.236984 (rank : 65)	θ value	0.0736092 (rank : 74)
Query Neighborhood Hits	168	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

CPNE3_HUMAN
NC score	0.235104 (rank : 66)	θ value	0.0193708 (rank : 60)
Query Neighborhood Hits	168	Target Neighborhood Hits	90	Shared Neighborhood Hits	81
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE8_HUMAN
NC score	0.234695 (rank : 67)	θ value	0.0113563 (rank : 55)
Query Neighborhood Hits	168	Target Neighborhood Hits	86	Shared Neighborhood Hits	77
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

SYTL3_MOUSE
NC score	0.232039 (rank : 68)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	168	Target Neighborhood Hits	110	Shared Neighborhood Hits	60
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

CPNE8_MOUSE
NC score	0.231810 (rank : 69)	θ value	0.0113563 (rank : 56)
Query Neighborhood Hits	168	Target Neighborhood Hits	85	Shared Neighborhood Hits	77
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE5_MOUSE
NC score	0.231496 (rank : 70)	θ value	0.0193708 (rank : 62)
Query Neighborhood Hits	168	Target Neighborhood Hits	86	Shared Neighborhood Hits	77
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_HUMAN
NC score	0.231352 (rank : 71)	θ value	0.0193708 (rank : 61)
Query Neighborhood Hits	168	Target Neighborhood Hits	88	Shared Neighborhood Hits	77
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

RASA2_MOUSE
NC score	0.227460 (rank : 72)	θ value	0.0330416 (rank : 67)
Query Neighborhood Hits	168	Target Neighborhood Hits	159	Shared Neighborhood Hits	71
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SYT13_HUMAN
NC score	0.226304 (rank : 73)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	168	Target Neighborhood Hits	76	Shared Neighborhood Hits	56
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
NC score	0.217487 (rank : 74)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	168	Target Neighborhood Hits	69	Shared Neighborhood Hits	53
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

CPNE7_HUMAN
NC score	0.214518 (rank : 75)	θ value	0.0193708 (rank : 63)
Query Neighborhood Hits	168	Target Neighborhood Hits	92	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

CPNE2_MOUSE
NC score	0.210782 (rank : 76)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	168	Target Neighborhood Hits	82	Shared Neighborhood Hits	72
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

RASA2_HUMAN
NC score	0.210622 (rank : 77)	θ value	0.279714 (rank : 83)
Query Neighborhood Hits	168	Target Neighborhood Hits	157	Shared Neighborhood Hits	68
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CPNE2_HUMAN
NC score	0.204466 (rank : 78)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	168	Target Neighborhood Hits	75	Shared Neighborhood Hits	69
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE1_MOUSE
NC score	0.203704 (rank : 79)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	168	Target Neighborhood Hits	83	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

PA24A_MOUSE
NC score	0.200361 (rank : 80)	θ value	0.21417 (rank : 80)
Query Neighborhood Hits	168	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

CPNE6_HUMAN
NC score	0.198711 (rank : 81)	θ value	0.0736092 (rank : 72)
Query Neighborhood Hits	168	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

NED4L_HUMAN
NC score	0.198529 (rank : 82)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	168	Target Neighborhood Hits	238	Shared Neighborhood Hits	100
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
NC score	0.198096 (rank : 83)	θ value	0.0148317 (rank : 59)
Query Neighborhood Hits	168	Target Neighborhood Hits	214	Shared Neighborhood Hits	97
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

CPNE6_MOUSE
NC score	0.195893 (rank : 84)	θ value	0.0736092 (rank : 73)
Query Neighborhood Hits	168	Target Neighborhood Hits	87	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

NED4L_MOUSE
NC score	0.195796 (rank : 85)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	168	Target Neighborhood Hits	231	Shared Neighborhood Hits	100
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SYT14_MOUSE
NC score	0.195745 (rank : 86)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	168	Target Neighborhood Hits	82	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

NEDD4_MOUSE
NC score	0.195574 (rank : 87)	θ value	0.0563607 (rank : 69)
Query Neighborhood Hits	168	Target Neighborhood Hits	212	Shared Neighborhood Hits	98
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PA24A_HUMAN
NC score	0.195358 (rank : 88)	θ value	0.21417 (rank : 79)
Query Neighborhood Hits	168	Target Neighborhood Hits	88	Shared Neighborhood Hits	69
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

RASA3_HUMAN
NC score	0.193787 (rank : 89)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	168	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SYT14_HUMAN
NC score	0.193443 (rank : 90)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	168	Target Neighborhood Hits	81	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

RIMS2_HUMAN
NC score	0.191208 (rank : 91)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	168	Target Neighborhood Hits	342	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.189574 (rank : 92)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	168	Target Neighborhood Hits	376	Shared Neighborhood Hits	88
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

PA24E_HUMAN
NC score	0.187938 (rank : 93)	θ value	0.21417 (rank : 81)
Query Neighborhood Hits	168	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

CPNE1_HUMAN
NC score	0.184278 (rank : 94)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	168	Target Neighborhood Hits	70	Shared Neighborhood Hits	69
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE4_HUMAN
NC score	0.179246 (rank : 95)	θ value	0.0736092 (rank : 70)
Query Neighborhood Hits	168	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

ITSN2_HUMAN
NC score	0.178937 (rank : 96)	θ value	3.19293e-05 (rank : 23)
Query Neighborhood Hits	168	Target Neighborhood Hits	1173	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PA24E_MOUSE
NC score	0.178692 (rank : 97)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	168	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

CPNE4_MOUSE
NC score	0.178644 (rank : 98)	θ value	0.0736092 (rank : 71)
Query Neighborhood Hits	168	Target Neighborhood Hits	67	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

RIMS1_HUMAN
NC score	0.178038 (rank : 99)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	168	Target Neighborhood Hits	437	Shared Neighborhood Hits	79
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RASA3_MOUSE
NC score	0.174005 (rank : 100)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	168	Target Neighborhood Hits	144	Shared Neighborhood Hits	64
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

ITSN2_MOUSE
NC score	0.168780 (rank : 101)	θ value	1.43324e-05 (rank : 13)
Query Neighborhood Hits	168	Target Neighborhood Hits	1371	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PA24B_HUMAN
NC score	0.168587 (rank : 102)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	168	Target Neighborhood Hits	89	Shared Neighborhood Hits	69
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24F_HUMAN
NC score	0.163554 (rank : 103)	θ value	0.0330416 (rank : 66)
Query Neighborhood Hits	168	Target Neighborhood Hits	78	Shared Neighborhood Hits	62
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PERF_MOUSE
NC score	0.157301 (rank : 104)	θ value	0.0193708 (rank : 64)
Query Neighborhood Hits	168	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

P3C2B_HUMAN
NC score	0.153717 (rank : 105)	θ value	5.27518 (rank : 139)
Query Neighborhood Hits	168	Target Neighborhood Hits	148	Shared Neighborhood Hits	63
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PA24F_MOUSE
NC score	0.147410 (rank : 106)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	168	Target Neighborhood Hits	93	Shared Neighborhood Hits	68
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PERF_HUMAN
NC score	0.143017 (rank : 107)	θ value	0.0431538 (rank : 68)
Query Neighborhood Hits	168	Target Neighborhood Hits	48	Shared Neighborhood Hits	26
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

RIMS4_MOUSE
NC score	0.138878 (rank : 108)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	168	Target Neighborhood Hits	76	Shared Neighborhood Hits	53
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.137516 (rank : 109)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	168	Target Neighborhood Hits	76	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

KPCG_MOUSE
NC score	0.131632 (rank : 110)	θ value	4.1701e-05 (rank : 27)
Query Neighborhood Hits	168	Target Neighborhood Hits	1123	Shared Neighborhood Hits	101
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.131474 (rank : 111)	θ value	4.1701e-05 (rank : 26)
Query Neighborhood Hits	168	Target Neighborhood Hits	1126	Shared Neighborhood Hits	101
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCB_MOUSE
NC score	0.125570 (rank : 112)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	168	Target Neighborhood Hits	1117	Shared Neighborhood Hits	102
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_HUMAN
NC score	0.125313 (rank : 113)	θ value	8.40245e-06 (rank : 11)
Query Neighborhood Hits	168	Target Neighborhood Hits	1070	Shared Neighborhood Hits	104
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
NC score	0.123939 (rank : 114)	θ value	2.44474e-05 (rank : 21)
Query Neighborhood Hits	168	Target Neighborhood Hits	1121	Shared Neighborhood Hits	102
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

ITSN1_MOUSE
NC score	0.123636 (rank : 115)	θ value	0.0148317 (rank : 58)
Query Neighborhood Hits	168	Target Neighborhood Hits	1669	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

KPCA_MOUSE
NC score	0.123184 (rank : 116)	θ value	3.19293e-05 (rank : 24)
Query Neighborhood Hits	168	Target Neighborhood Hits	1067	Shared Neighborhood Hits	104
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

ITSN1_HUMAN
NC score	0.122433 (rank : 117)	θ value	0.0148317 (rank : 57)
Query Neighborhood Hits	168	Target Neighborhood Hits	1757	Shared Neighborhood Hits	111
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

P3C2A_HUMAN
NC score	0.118102 (rank : 118)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	168	Target Neighborhood Hits	188	Shared Neighborhood Hits	60
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
NC score	0.117026 (rank : 119)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	168	Target Neighborhood Hits	181	Shared Neighborhood Hits	57
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

RFIP1_HUMAN
NC score	0.116182 (rank : 120)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	168	Target Neighborhood Hits	236	Shared Neighborhood Hits	36
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RFIP1_MOUSE
NC score	0.110776 (rank : 121)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	168	Target Neighborhood Hits	152	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

TAC2N_HUMAN
NC score	0.108753 (rank : 122)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	168	Target Neighborhood Hits	47	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
NC score	0.105879 (rank : 123)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	168	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

RIMS3_HUMAN
NC score	0.105819 (rank : 124)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	168	Target Neighborhood Hits	66	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
NC score	0.102562 (rank : 125)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	168	Target Neighborhood Hits	67	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SMUF2_HUMAN
NC score	0.102060 (rank : 126)	θ value	0.365318 (rank : 84)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
NC score	0.100514 (rank : 127)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	168	Target Neighborhood Hits	135	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.099648 (rank : 128)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	168	Target Neighborhood Hits	142	Shared Neighborhood Hits	68
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

PLCD1_HUMAN
NC score	0.092895 (rank : 129)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	168	Target Neighborhood Hits	93	Shared Neighborhood Hits	54
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

RASA1_HUMAN
NC score	0.083997 (rank : 130)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	168	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RGS3_HUMAN
NC score	0.075646 (rank : 131)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	168	Target Neighborhood Hits	1375	Shared Neighborhood Hits	59
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

PLCD1_MOUSE
NC score	0.069899 (rank : 132)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	168	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PA24C_HUMAN
NC score	0.063106 (rank : 133)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	168	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UP65, O75457, Q9UG68	Gene names	PLA2G4C
Domain Architecture
Description	Cytosolic phospholipase A2 gamma precursor (EC 3.1.1.4) (cPLA2-gamma) (Phospholipase A2 group IVC).

WWC1_MOUSE
NC score	0.056740 (rank : 134)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	168	Target Neighborhood Hits	290	Shared Neighborhood Hits	46
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

DAB2P_HUMAN
NC score	0.053005 (rank : 135)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	168	Target Neighborhood Hits	303	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

SYGP1_HUMAN
NC score	0.051995 (rank : 136)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	168	Target Neighborhood Hits	589	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

DAB2P_MOUSE
NC score	0.051192 (rank : 137)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	168	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

WWP1_MOUSE
NC score	0.050757 (rank : 138)	θ value	4.03905 (rank : 131)
Query Neighborhood Hits	168	Target Neighborhood Hits	138	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

CDC5L_MOUSE
NC score	0.050144 (rank : 139)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	168	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q6A068, Q8K1J9	Gene names	Cdc5l, Kiaa0432
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-related protein (Cdc5-like protein).

ITCH_HUMAN
NC score	0.047339 (rank : 140)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	168	Target Neighborhood Hits	162	Shared Neighborhood Hits	28
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

CDC5L_HUMAN
NC score	0.043588 (rank : 141)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	168	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q99459, Q76N46, Q99974	Gene names	CDC5L, KIAA0432, PCDC5RP
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5- related protein).

LACTB_MOUSE
NC score	0.042376 (rank : 142)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	168	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EP89	Gene names	Lactb, Lact1
Domain Architecture
Description	Serine beta-lactamase-like protein LACTB.

MDN1_HUMAN
NC score	0.038908 (rank : 143)	θ value	2.36792 (rank : 104)
Query Neighborhood Hits	168	Target Neighborhood Hits	662	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

RGNEF_MOUSE
NC score	0.038221 (rank : 144)	θ value	4.03905 (rank : 124)
Query Neighborhood Hits	168	Target Neighborhood Hits	641	Shared Neighborhood Hits	31
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

LRRF1_MOUSE
NC score	0.033729 (rank : 145)	θ value	0.125558 (rank : 75)
Query Neighborhood Hits	168	Target Neighborhood Hits	440	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

CT102_MOUSE
NC score	0.030285 (rank : 146)	θ value	5.27518 (rank : 133)
Query Neighborhood Hits	168	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDS0	Gene names	Gm691
Domain Architecture	No domain graphic available
Description	Protein C20orf102 homolog precursor.

ACINU_HUMAN
NC score	0.029195 (rank : 147)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	168	Target Neighborhood Hits	828	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

NIPBL_HUMAN
NC score	0.028662 (rank : 148)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	168	Target Neighborhood Hits	1311	Shared Neighborhood Hits	29
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

CDT1_MOUSE
NC score	0.028312 (rank : 149)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	168	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

PIR_HUMAN
NC score	0.027168 (rank : 150)	θ value	4.03905 (rank : 123)
Query Neighborhood Hits	168	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O00625, Q5U0G0	Gene names	PIR
Domain Architecture
Description	Pirin.

AKA12_HUMAN
NC score	0.026685 (rank : 151)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	168	Target Neighborhood Hits	825	Shared Neighborhood Hits	25
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

RUFY3_HUMAN
NC score	0.024869 (rank : 152)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	168	Target Neighborhood Hits	594	Shared Neighborhood Hits	21
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SNUT1_HUMAN
NC score	0.024820 (rank : 153)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	168	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

RUFY3_MOUSE
NC score	0.024246 (rank : 154)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	168	Target Neighborhood Hits	579	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

TCRG1_MOUSE
NC score	0.021557 (rank : 155)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	168	Target Neighborhood Hits	947	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

K0841_HUMAN
NC score	0.020924 (rank : 156)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	168	Target Neighborhood Hits	119	Shared Neighborhood Hits	8
SwissProt Accessions	O94927, Q6P2P7, Q7L3D5, Q96CT8	Gene names	KIAA0841
Domain Architecture	No domain graphic available
Description	Protein KIAA0841.

CTRO_MOUSE
NC score	0.020868 (rank : 157)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	168	Target Neighborhood Hits	2344	Shared Neighborhood Hits	48
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ADIP_MOUSE
NC score	0.020139 (rank : 158)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	168	Target Neighborhood Hits	415	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

TXLNB_HUMAN
NC score	0.019744 (rank : 159)	θ value	4.03905 (rank : 130)
Query Neighborhood Hits	168	Target Neighborhood Hits	912	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

ARP2_HUMAN
NC score	0.019629 (rank : 160)	θ value	0.47712 (rank : 87)
Query Neighborhood Hits	168	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	P61160, O15142, Q96C82	Gene names	ACTR2, ARP2
Domain Architecture
Description	Actin-like protein 2 (Actin-related protein 2).

ARP2_MOUSE
NC score	0.019629 (rank : 161)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	168	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	P61161, O15142	Gene names	Actr2, Arp2
Domain Architecture
Description	Actin-like protein 2 (Actin-related protein 2).

TCTP_MOUSE
NC score	0.019509 (rank : 162)	θ value	4.03905 (rank : 129)
Query Neighborhood Hits	168	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P63028, P14701, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9	Gene names	Tpt1, Trt
Domain Architecture	No domain graphic available
Description	Translationally-controlled tumor protein (TCTP) (p23) (21 kDa polypeptide) (p21).

SAFB2_MOUSE
NC score	0.018882 (rank : 163)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	168	Target Neighborhood Hits	581	Shared Neighborhood Hits	23
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

CCHCR_HUMAN
NC score	0.018196 (rank : 164)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	168	Target Neighborhood Hits	717	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

TCTP_HUMAN
NC score	0.018065 (rank : 165)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	168	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P13693, Q6YLS2, Q7Z4J4, Q96EE2, Q9UC70	Gene names	TPT1
Domain Architecture
Description	Translationally-controlled tumor protein (TCTP) (p23) (Histamine- releasing factor) (HRF) (Fortilin).

GOGB1_HUMAN
NC score	0.017642 (rank : 166)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	168	Target Neighborhood Hits	2297	Shared Neighborhood Hits	42
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

K1196_HUMAN
NC score	0.017233 (rank : 167)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	168	Target Neighborhood Hits	618	Shared Neighborhood Hits	5
SwissProt Accessions	Q96KM6, Q9ULM4	Gene names	KIAA1196
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1196.

CF010_HUMAN
NC score	0.016925 (rank : 168)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	168	Target Neighborhood Hits	329	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SRN2, Q5SPI9, Q5SPJ0, Q5SPK9, Q5SPL0, Q5SRN3, Q5TG25, Q5TG26, Q8N4B6	Gene names	C6orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf10.

SPRL1_MOUSE
NC score	0.015643 (rank : 169)	θ value	4.03905 (rank : 127)
Query Neighborhood Hits	168	Target Neighborhood Hits	403	Shared Neighborhood Hits	16
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

GON4L_HUMAN
NC score	0.015569 (rank : 170)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	168	Target Neighborhood Hits	555	Shared Neighborhood Hits	17
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

NP1L4_MOUSE
NC score	0.015569 (rank : 171)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	168	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q78ZA7, O88701	Gene names	Nap1l4
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 4.

CP250_MOUSE
NC score	0.015463 (rank : 172)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	168	Target Neighborhood Hits	1583	Shared Neighborhood Hits	34
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MY18A_HUMAN
NC score	0.015109 (rank : 173)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	168	Target Neighborhood Hits	1929	Shared Neighborhood Hits	39
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

HDGR3_MOUSE
NC score	0.014801 (rank : 174)	θ value	5.27518 (rank : 137)
Query Neighborhood Hits	168	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMG7, Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7	Gene names	Hdgfrp3
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3).

HOOK2_MOUSE
NC score	0.014749 (rank : 175)	θ value	5.27518 (rank : 138)
Query Neighborhood Hits	168	Target Neighborhood Hits	736	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

HDGR3_HUMAN
NC score	0.014736 (rank : 176)	θ value	5.27518 (rank : 136)
Query Neighborhood Hits	168	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

TDRD1_MOUSE
NC score	0.014180 (rank : 177)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	168	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MV1	Gene names	Tdrd1
Domain Architecture
Description	Tudor domain-containing protein 1.

CE290_HUMAN
NC score	0.013726 (rank : 178)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	168	Target Neighborhood Hits	1553	Shared Neighborhood Hits	33
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

RAD50_MOUSE
NC score	0.013125 (rank : 179)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	168	Target Neighborhood Hits	1366	Shared Neighborhood Hits	35
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

TRI66_MOUSE
NC score	0.012849 (rank : 180)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	168	Target Neighborhood Hits	491	Shared Neighborhood Hits	14
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ANGL4_HUMAN
NC score	0.012845 (rank : 181)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	168	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BY76, Q53HQ6, Q53HU1, Q6UXN0, Q9HBV4, Q9NZU4, Q9Y5B3	Gene names	ANGPTL4, ARP4, HFARP, PGAR
Domain Architecture
Description	Angiopoietin-related protein 4 precursor (Angiopoietin-like 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP).

AFAD_HUMAN
NC score	0.012610 (rank : 182)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	168	Target Neighborhood Hits	689	Shared Neighborhood Hits	22
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

STK10_HUMAN
NC score	0.012550 (rank : 183)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	168	Target Neighborhood Hits	1921	Shared Neighborhood Hits	34
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

SI1L1_HUMAN
NC score	0.012035 (rank : 184)	θ value	4.03905 (rank : 125)
Query Neighborhood Hits	168	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
NC score	0.011770 (rank : 185)	θ value	4.03905 (rank : 126)
Query Neighborhood Hits	168	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

CE005_MOUSE
NC score	0.010867 (rank : 186)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	168	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

EYA1_MOUSE
NC score	0.009321 (rank : 187)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	168	Target Neighborhood Hits	108	Shared Neighborhood Hits	3
SwissProt Accessions	P97767, O08818	Gene names	Eya1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

MYH9_MOUSE
NC score	0.008661 (rank : 188)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	168	Target Neighborhood Hits	1829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_HUMAN
NC score	0.008073 (rank : 189)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	168	Target Neighborhood Hits	1762	Shared Neighborhood Hits	35
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH13_HUMAN
NC score	0.007098 (rank : 190)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	168	Target Neighborhood Hits	1504	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

BTBD3_MOUSE
NC score	0.006191 (rank : 191)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	168	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	P58545	Gene names	Btbd3
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

BTBD3_HUMAN
NC score	0.006181 (rank : 192)	θ value	6.88961 (rank : 145)
Query Neighborhood Hits	168	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2F9	Gene names	BTBD3, KIAA0952
Domain Architecture
Description	BTB/POZ domain-containing protein 3.

PTPRT_HUMAN
NC score	0.005329 (rank : 193)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	168	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
NC score	0.005244 (rank : 194)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	168	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PER2_MOUSE
NC score	0.005196 (rank : 195)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	168	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HS105_HUMAN
NC score	0.005183 (rank : 196)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	168	Target Neighborhood Hits	209	Shared Neighborhood Hits	10
SwissProt Accessions	Q92598, O95739, Q5TBM6, Q5TBM8, Q9UPC4	Gene names	HSPH1, HSP105, HSP110, KIAA0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY- CO-25).

DLX2_MOUSE
NC score	0.003640 (rank : 197)	θ value	5.27518 (rank : 134)
Query Neighborhood Hits	168	Target Neighborhood Hits	352	Shared Neighborhood Hits	3
SwissProt Accessions	P40764	Gene names	Dlx2, Tes-1, Tes1
Domain Architecture
Description	Homeobox protein DLX-2 (Homeobox protein TES-1).

INHBE_HUMAN
NC score	0.002893 (rank : 198)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	168	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P58166	Gene names	INHBE
Domain Architecture
Description	Inhibin beta E chain precursor (Activin beta-E chain).

PHLPL_HUMAN
NC score	0.000563 (rank : 199)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	168	Target Neighborhood Hits	310	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PCDA5_HUMAN
NC score	0.000548 (rank : 200)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	168	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

FATH_HUMAN
NC score	0.000383 (rank : 201)	θ value	5.27518 (rank : 135)
Query Neighborhood Hits	168	Target Neighborhood Hits	570	Shared Neighborhood Hits	7
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

RLF_HUMAN
NC score	-0.000709 (rank : 202)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	168	Target Neighborhood Hits	775	Shared Neighborhood Hits	7
SwissProt Accessions	Q13129, Q9NU60	Gene names	RLF
Domain Architecture	No domain graphic available
Description	Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15- related protein).

HIC2_MOUSE
NC score	-0.003144 (rank : 203)	θ value	2.36792 (rank : 103)
Query Neighborhood Hits	168	Target Neighborhood Hits	821	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLZ6, Q3U030, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5	Gene names	Hic2, Kiaa1020
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2).