Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : DYSF_HUMAN

For an explanation of this page, click here

DYSF_HUMAN
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DYSF_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	170	Target Neighborhood Hits	170	Shared Neighborhood Hits	170
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

DYSF_MOUSE
θ value	0 (rank : 2)	NC score	0.993568 (rank : 2)
Query Neighborhood Hits	170	Target Neighborhood Hits	162	Shared Neighborhood Hits	133
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

MYOF_HUMAN
θ value	0 (rank : 3)	NC score	0.980005 (rank : 3)
Query Neighborhood Hits	170	Target Neighborhood Hits	147	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

OTOF_HUMAN
θ value	0 (rank : 4)	NC score	0.916488 (rank : 4)
Query Neighborhood Hits	170	Target Neighborhood Hits	168	Shared Neighborhood Hits	102
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	0 (rank : 5)	NC score	0.914405 (rank : 5)
Query Neighborhood Hits	170	Target Neighborhood Hits	196	Shared Neighborhood Hits	102
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

RASL1_HUMAN
θ value	3.89403e-11 (rank : 6)	NC score	0.431337 (rank : 11)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	108
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	3.29651e-10 (rank : 7)	NC score	0.413804 (rank : 20)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

PCLO_HUMAN
θ value	2.36244e-08 (rank : 8)	NC score	0.321861 (rank : 51)
Query Neighborhood Hits	170	Target Neighborhood Hits	2046	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	4.45536e-07 (rank : 9)	NC score	0.303019 (rank : 53)
Query Neighborhood Hits	170	Target Neighborhood Hits	2275	Shared Neighborhood Hits	144
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

DOC2B_HUMAN
θ value	7.59969e-07 (rank : 10)	NC score	0.432146 (rank : 8)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	125
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RASL2_HUMAN
θ value	7.59969e-07 (rank : 11)	NC score	0.414723 (rank : 19)
Query Neighborhood Hits	170	Target Neighborhood Hits	161	Shared Neighborhood Hits	120
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

DOC2B_MOUSE
θ value	1.69304e-06 (rank : 12)	NC score	0.430544 (rank : 12)
Query Neighborhood Hits	170	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RP3A_HUMAN
θ value	1.69304e-06 (rank : 13)	NC score	0.423226 (rank : 15)
Query Neighborhood Hits	170	Target Neighborhood Hits	305	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT10_MOUSE
θ value	1.69304e-06 (rank : 14)	NC score	0.422329 (rank : 16)
Query Neighborhood Hits	170	Target Neighborhood Hits	133	Shared Neighborhood Hits	122
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT6_HUMAN
θ value	1.69304e-06 (rank : 15)	NC score	0.413389 (rank : 22)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	121
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
θ value	1.69304e-06 (rank : 16)	NC score	0.413780 (rank : 21)
Query Neighborhood Hits	170	Target Neighborhood Hits	132	Shared Neighborhood Hits	121
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT10_HUMAN
θ value	2.88788e-06 (rank : 17)	NC score	0.418166 (rank : 18)
Query Neighborhood Hits	170	Target Neighborhood Hits	134	Shared Neighborhood Hits	122
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT3_HUMAN
θ value	2.88788e-06 (rank : 18)	NC score	0.424764 (rank : 14)
Query Neighborhood Hits	170	Target Neighborhood Hits	145	Shared Neighborhood Hits	122
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	2.88788e-06 (rank : 19)	NC score	0.424938 (rank : 13)
Query Neighborhood Hits	170	Target Neighborhood Hits	147	Shared Neighborhood Hits	122
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

FA62A_MOUSE
θ value	3.77169e-06 (rank : 20)	NC score	0.434746 (rank : 6)
Query Neighborhood Hits	170	Target Neighborhood Hits	155	Shared Neighborhood Hits	127
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

ITSN2_HUMAN
θ value	3.77169e-06 (rank : 21)	NC score	0.178717 (rank : 98)
Query Neighborhood Hits	170	Target Neighborhood Hits	1173	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RP3A_MOUSE
θ value	3.77169e-06 (rank : 22)	NC score	0.422185 (rank : 17)
Query Neighborhood Hits	170	Target Neighborhood Hits	510	Shared Neighborhood Hits	130
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

KPCA_HUMAN
θ value	4.92598e-06 (rank : 23)	NC score	0.129433 (rank : 117)
Query Neighborhood Hits	170	Target Neighborhood Hits	1070	Shared Neighborhood Hits	126
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCG_MOUSE
θ value	6.43352e-06 (rank : 24)	NC score	0.136956 (rank : 114)
Query Neighborhood Hits	170	Target Neighborhood Hits	1123	Shared Neighborhood Hits	122
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

FA62A_HUMAN
θ value	8.40245e-06 (rank : 25)	NC score	0.431909 (rank : 9)
Query Neighborhood Hits	170	Target Neighborhood Hits	168	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

KPCG_HUMAN
θ value	8.40245e-06 (rank : 26)	NC score	0.136573 (rank : 115)
Query Neighborhood Hits	170	Target Neighborhood Hits	1126	Shared Neighborhood Hits	123
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

ITSN2_MOUSE
θ value	1.87187e-05 (rank : 27)	NC score	0.166742 (rank : 100)
Query Neighborhood Hits	170	Target Neighborhood Hits	1371	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DOC2A_MOUSE
θ value	2.44474e-05 (rank : 28)	NC score	0.433727 (rank : 7)
Query Neighborhood Hits	170	Target Neighborhood Hits	140	Shared Neighborhood Hits	124
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2A_HUMAN
θ value	3.19293e-05 (rank : 29)	NC score	0.431437 (rank : 10)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	123
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

SYT9_HUMAN
θ value	3.19293e-05 (rank : 30)	NC score	0.410872 (rank : 25)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	122
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	3.19293e-05 (rank : 31)	NC score	0.410605 (rank : 26)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

KPCA_MOUSE
θ value	4.1701e-05 (rank : 32)	NC score	0.127185 (rank : 120)
Query Neighborhood Hits	170	Target Neighborhood Hits	1067	Shared Neighborhood Hits	126
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYTL1_HUMAN
θ value	4.1701e-05 (rank : 33)	NC score	0.347715 (rank : 43)
Query Neighborhood Hits	170	Target Neighborhood Hits	227	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

KPCB_HUMAN
θ value	7.1131e-05 (rank : 34)	NC score	0.127590 (rank : 119)
Query Neighborhood Hits	170	Target Neighborhood Hits	1121	Shared Neighborhood Hits	123
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	9.29e-05 (rank : 35)	NC score	0.129099 (rank : 118)
Query Neighborhood Hits	170	Target Neighborhood Hits	1117	Shared Neighborhood Hits	123
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

SYT5_HUMAN
θ value	9.29e-05 (rank : 36)	NC score	0.412256 (rank : 24)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	125
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
θ value	9.29e-05 (rank : 37)	NC score	0.412898 (rank : 23)
Query Neighborhood Hits	170	Target Neighborhood Hits	140	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYTL2_MOUSE
θ value	0.000158464 (rank : 38)	NC score	0.364455 (rank : 35)
Query Neighborhood Hits	170	Target Neighborhood Hits	253	Shared Neighborhood Hits	101
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_HUMAN
θ value	0.00020696 (rank : 39)	NC score	0.364827 (rank : 34)
Query Neighborhood Hits	170	Target Neighborhood Hits	248	Shared Neighborhood Hits	100
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYT4_HUMAN
θ value	0.000461057 (rank : 40)	NC score	0.362496 (rank : 36)
Query Neighborhood Hits	170	Target Neighborhood Hits	121	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT2_HUMAN
θ value	0.000602161 (rank : 41)	NC score	0.403265 (rank : 32)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	125
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
θ value	0.000602161 (rank : 42)	NC score	0.404293 (rank : 31)
Query Neighborhood Hits	170	Target Neighborhood Hits	143	Shared Neighborhood Hits	125
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYTL1_MOUSE
θ value	0.000602161 (rank : 43)	NC score	0.325582 (rank : 50)
Query Neighborhood Hits	170	Target Neighborhood Hits	314	Shared Neighborhood Hits	94
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

K0528_HUMAN
θ value	0.00102713 (rank : 44)	NC score	0.338512 (rank : 45)
Query Neighborhood Hits	170	Target Neighborhood Hits	96	Shared Neighborhood Hits	84
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	0.00102713 (rank : 45)	NC score	0.338116 (rank : 46)
Query Neighborhood Hits	170	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

BAIP3_HUMAN
θ value	0.00134147 (rank : 46)	NC score	0.351889 (rank : 42)
Query Neighborhood Hits	170	Target Neighborhood Hits	108	Shared Neighborhood Hits	87
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

PA24B_MOUSE
θ value	0.00134147 (rank : 47)	NC score	0.227533 (rank : 68)
Query Neighborhood Hits	170	Target Neighborhood Hits	102	Shared Neighborhood Hits	83
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

SYT1_HUMAN
θ value	0.00134147 (rank : 48)	NC score	0.406453 (rank : 29)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	125
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	0.00134147 (rank : 49)	NC score	0.406444 (rank : 30)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	125
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

BAIP3_MOUSE
θ value	0.00228821 (rank : 50)	NC score	0.353708 (rank : 41)
Query Neighborhood Hits	170	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

UN13A_HUMAN
θ value	0.00228821 (rank : 51)	NC score	0.298062 (rank : 56)
Query Neighborhood Hits	170	Target Neighborhood Hits	285	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

SYT7_HUMAN
θ value	0.00298849 (rank : 52)	NC score	0.408520 (rank : 27)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	123
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

UN13B_HUMAN
θ value	0.00298849 (rank : 53)	NC score	0.277489 (rank : 62)
Query Neighborhood Hits	170	Target Neighborhood Hits	217	Shared Neighborhood Hits	112
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	0.00298849 (rank : 54)	NC score	0.295565 (rank : 57)
Query Neighborhood Hits	170	Target Neighborhood Hits	210	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYT7_MOUSE
θ value	0.00509761 (rank : 55)	NC score	0.406456 (rank : 28)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

DOC2G_MOUSE
θ value	0.00665767 (rank : 56)	NC score	0.402586 (rank : 33)
Query Neighborhood Hits	170	Target Neighborhood Hits	125	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT4_MOUSE
θ value	0.00665767 (rank : 57)	NC score	0.358583 (rank : 37)
Query Neighborhood Hits	170	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYTL4_MOUSE
θ value	0.00665767 (rank : 58)	NC score	0.326836 (rank : 48)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	95
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

CPNE7_HUMAN
θ value	0.00869519 (rank : 59)	NC score	0.206437 (rank : 86)
Query Neighborhood Hits	170	Target Neighborhood Hits	92	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

NED4L_HUMAN
θ value	0.00869519 (rank : 60)	NC score	0.218489 (rank : 78)
Query Neighborhood Hits	170	Target Neighborhood Hits	238	Shared Neighborhood Hits	124
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SYT11_MOUSE
θ value	0.0113563 (rank : 61)	NC score	0.357782 (rank : 39)
Query Neighborhood Hits	170	Target Neighborhood Hits	116	Shared Neighborhood Hits	104
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
θ value	0.0148317 (rank : 62)	NC score	0.356017 (rank : 40)
Query Neighborhood Hits	170	Target Neighborhood Hits	113	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYTL4_HUMAN
θ value	0.0148317 (rank : 63)	NC score	0.326552 (rank : 49)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	93
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

UN13D_HUMAN
θ value	0.0148317 (rank : 64)	NC score	0.358265 (rank : 38)
Query Neighborhood Hits	170	Target Neighborhood Hits	117	Shared Neighborhood Hits	97
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

CPNE2_MOUSE
θ value	0.0193708 (rank : 65)	NC score	0.211837 (rank : 81)
Query Neighborhood Hits	170	Target Neighborhood Hits	82	Shared Neighborhood Hits	74
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

NEDD4_MOUSE
θ value	0.0193708 (rank : 66)	NC score	0.210197 (rank : 83)
Query Neighborhood Hits	170	Target Neighborhood Hits	212	Shared Neighborhood Hits	120
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

CPNE6_HUMAN
θ value	0.0252991 (rank : 67)	NC score	0.192667 (rank : 94)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

ITSN1_HUMAN
θ value	0.0252991 (rank : 68)	NC score	0.119286 (rank : 122)
Query Neighborhood Hits	170	Target Neighborhood Hits	1757	Shared Neighborhood Hits	107
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.0252991 (rank : 69)	NC score	0.120737 (rank : 121)
Query Neighborhood Hits	170	Target Neighborhood Hits	1669	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

CPNE8_HUMAN
θ value	0.0330416 (rank : 70)	NC score	0.222916 (rank : 71)
Query Neighborhood Hits	170	Target Neighborhood Hits	86	Shared Neighborhood Hits	78
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE8_MOUSE
θ value	0.0330416 (rank : 71)	NC score	0.220055 (rank : 76)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	77
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

RFIP1_HUMAN
θ value	0.0330416 (rank : 72)	NC score	0.150491 (rank : 110)
Query Neighborhood Hits	170	Target Neighborhood Hits	236	Shared Neighborhood Hits	44
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

P3C2B_HUMAN
θ value	0.0431538 (rank : 73)	NC score	0.197320 (rank : 89)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	80
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

RFIP2_HUMAN
θ value	0.0431538 (rank : 74)	NC score	0.310386 (rank : 52)
Query Neighborhood Hits	170	Target Neighborhood Hits	97	Shared Neighborhood Hits	75
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

CPNE3_HUMAN
θ value	0.0563607 (rank : 75)	NC score	0.222838 (rank : 72)
Query Neighborhood Hits	170	Target Neighborhood Hits	90	Shared Neighborhood Hits	80
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

NED4L_MOUSE
θ value	0.0563607 (rank : 76)	NC score	0.214521 (rank : 80)
Query Neighborhood Hits	170	Target Neighborhood Hits	231	Shared Neighborhood Hits	122
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PERF_MOUSE
θ value	0.0563607 (rank : 77)	NC score	0.132434 (rank : 116)
Query Neighborhood Hits	170	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

CPNE3_MOUSE
θ value	0.0736092 (rank : 78)	NC score	0.225298 (rank : 70)
Query Neighborhood Hits	170	Target Neighborhood Hits	90	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE5_HUMAN
θ value	0.0736092 (rank : 79)	NC score	0.219920 (rank : 77)
Query Neighborhood Hits	170	Target Neighborhood Hits	88	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	0.0736092 (rank : 80)	NC score	0.220295 (rank : 74)
Query Neighborhood Hits	170	Target Neighborhood Hits	86	Shared Neighborhood Hits	78
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

PA24D_MOUSE
θ value	0.0736092 (rank : 81)	NC score	0.259318 (rank : 64)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	92
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

SYTL3_MOUSE
θ value	0.0736092 (rank : 82)	NC score	0.302362 (rank : 54)
Query Neighborhood Hits	170	Target Neighborhood Hits	110	Shared Neighborhood Hits	82
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

ASPP1_MOUSE
θ value	0.0961366 (rank : 83)	NC score	0.034018 (rank : 139)
Query Neighborhood Hits	170	Target Neighborhood Hits	1244	Shared Neighborhood Hits	23
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PA24F_HUMAN
θ value	0.0961366 (rank : 84)	NC score	0.143412 (rank : 111)
Query Neighborhood Hits	170	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

CPNE6_MOUSE
θ value	0.125558 (rank : 85)	NC score	0.188286 (rank : 95)
Query Neighborhood Hits	170	Target Neighborhood Hits	87	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

SYTL5_HUMAN
θ value	0.125558 (rank : 86)	NC score	0.335761 (rank : 47)
Query Neighborhood Hits	170	Target Neighborhood Hits	237	Shared Neighborhood Hits	113
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

CPNE1_HUMAN
θ value	0.163984 (rank : 87)	NC score	0.180604 (rank : 97)
Query Neighborhood Hits	170	Target Neighborhood Hits	70	Shared Neighborhood Hits	69
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

SYTL5_MOUSE
θ value	0.163984 (rank : 88)	NC score	0.341067 (rank : 44)
Query Neighborhood Hits	170	Target Neighborhood Hits	154	Shared Neighborhood Hits	111
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

NEDD4_HUMAN
θ value	0.21417 (rank : 89)	NC score	0.211099 (rank : 82)
Query Neighborhood Hits	170	Target Neighborhood Hits	214	Shared Neighborhood Hits	120
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SMUF1_HUMAN
θ value	0.279714 (rank : 90)	NC score	0.105956 (rank : 127)
Query Neighborhood Hits	170	Target Neighborhood Hits	135	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	0.279714 (rank : 91)	NC score	0.104974 (rank : 129)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SYT13_HUMAN
θ value	0.279714 (rank : 92)	NC score	0.261861 (rank : 63)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

CPNE1_MOUSE
θ value	0.365318 (rank : 93)	NC score	0.199122 (rank : 88)
Query Neighborhood Hits	170	Target Neighborhood Hits	83	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

PA24A_HUMAN
θ value	0.365318 (rank : 94)	NC score	0.187505 (rank : 96)
Query Neighborhood Hits	170	Target Neighborhood Hits	88	Shared Neighborhood Hits	79
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24A_MOUSE
θ value	0.365318 (rank : 95)	NC score	0.193102 (rank : 93)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	78
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24F_MOUSE
θ value	0.365318 (rank : 96)	NC score	0.138862 (rank : 112)
Query Neighborhood Hits	170	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

RFIP1_MOUSE
θ value	0.365318 (rank : 97)	NC score	0.137396 (rank : 113)
Query Neighborhood Hits	170	Target Neighborhood Hits	152	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RIMS4_HUMAN
θ value	0.365318 (rank : 98)	NC score	0.194157 (rank : 91)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	0.365318 (rank : 99)	NC score	0.195810 (rank : 90)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	70
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RPGR1_HUMAN
θ value	0.365318 (rank : 100)	NC score	0.034333 (rank : 138)
Query Neighborhood Hits	170	Target Neighborhood Hits	578	Shared Neighborhood Hits	18
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SYNJ2_HUMAN
θ value	0.365318 (rank : 101)	NC score	0.019833 (rank : 148)
Query Neighborhood Hits	170	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

CPNE2_HUMAN
θ value	0.47712 (rank : 102)	NC score	0.202077 (rank : 87)
Query Neighborhood Hits	170	Target Neighborhood Hits	75	Shared Neighborhood Hits	71
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CEL_HUMAN
θ value	0.62314 (rank : 103)	NC score	0.011320 (rank : 160)
Query Neighborhood Hits	170	Target Neighborhood Hits	896	Shared Neighborhood Hits	21
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

GBX1_MOUSE
θ value	0.62314 (rank : 104)	NC score	0.005811 (rank : 172)
Query Neighborhood Hits	170	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P82976, Q8CGW5	Gene names	Gbx1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

NCOA6_MOUSE
θ value	0.62314 (rank : 105)	NC score	0.025645 (rank : 143)
Query Neighborhood Hits	170	Target Neighborhood Hits	1076	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RIMS2_HUMAN
θ value	0.813845 (rank : 106)	NC score	0.244665 (rank : 66)
Query Neighborhood Hits	170	Target Neighborhood Hits	342	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	0.813845 (rank : 107)	NC score	0.242389 (rank : 67)
Query Neighborhood Hits	170	Target Neighborhood Hits	376	Shared Neighborhood Hits	106
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

COBA1_MOUSE
θ value	1.06291 (rank : 108)	NC score	0.009454 (rank : 165)
Query Neighborhood Hits	170	Target Neighborhood Hits	487	Shared Neighborhood Hits	15
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

MAVS_HUMAN
θ value	1.06291 (rank : 109)	NC score	0.028070 (rank : 141)
Query Neighborhood Hits	170	Target Neighborhood Hits	271	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

WWP1_MOUSE
θ value	1.06291 (rank : 110)	NC score	0.062360 (rank : 133)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

P3C2G_MOUSE
θ value	1.38821 (rank : 111)	NC score	0.063712 (rank : 132)
Query Neighborhood Hits	170	Target Neighborhood Hits	113	Shared Neighborhood Hits	61
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

SMUF2_HUMAN
θ value	1.38821 (rank : 112)	NC score	0.105949 (rank : 128)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SYT15_MOUSE
θ value	1.38821 (rank : 113)	NC score	0.279784 (rank : 61)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	90
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

P3C2A_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.161077 (rank : 105)
Query Neighborhood Hits	170	Target Neighborhood Hits	188	Shared Neighborhood Hits	75
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

RGS3_HUMAN
θ value	1.81305 (rank : 115)	NC score	0.095204 (rank : 130)
Query Neighborhood Hits	170	Target Neighborhood Hits	1375	Shared Neighborhood Hits	88
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SYT8_MOUSE
θ value	1.81305 (rank : 116)	NC score	0.292505 (rank : 58)
Query Neighborhood Hits	170	Target Neighborhood Hits	94	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

HPS3_HUMAN
θ value	2.36792 (rank : 117)	NC score	0.025180 (rank : 144)
Query Neighborhood Hits	170	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q969F9, Q8WTV6, Q96AP1, Q96MR3, Q9H608	Gene names	HPS3
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 3 protein.

MACF4_HUMAN
θ value	2.36792 (rank : 118)	NC score	0.008580 (rank : 167)
Query Neighborhood Hits	170	Target Neighborhood Hits	1321	Shared Neighborhood Hits	18
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

P3C2A_MOUSE
θ value	2.36792 (rank : 119)	NC score	0.159354 (rank : 106)
Query Neighborhood Hits	170	Target Neighborhood Hits	181	Shared Neighborhood Hits	74
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

ARHGC_MOUSE
θ value	3.0926 (rank : 120)	NC score	0.031764 (rank : 140)
Query Neighborhood Hits	170	Target Neighborhood Hits	344	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

COGA1_HUMAN
θ value	3.0926 (rank : 121)	NC score	0.011596 (rank : 158)
Query Neighborhood Hits	170	Target Neighborhood Hits	345	Shared Neighborhood Hits	15
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

CPNE4_HUMAN
θ value	3.0926 (rank : 122)	NC score	0.162907 (rank : 103)
Query Neighborhood Hits	170	Target Neighborhood Hits	70	Shared Neighborhood Hits	67
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	3.0926 (rank : 123)	NC score	0.162067 (rank : 104)
Query Neighborhood Hits	170	Target Neighborhood Hits	67	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CUTL2_HUMAN
θ value	3.0926 (rank : 124)	NC score	0.008701 (rank : 166)
Query Neighborhood Hits	170	Target Neighborhood Hits	906	Shared Neighborhood Hits	13
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

ELK4_HUMAN
θ value	3.0926 (rank : 125)	NC score	0.011354 (rank : 159)
Query Neighborhood Hits	170	Target Neighborhood Hits	184	Shared Neighborhood Hits	8
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

FLNB_HUMAN
θ value	3.0926 (rank : 126)	NC score	0.014106 (rank : 152)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

FLNB_MOUSE
θ value	3.0926 (rank : 127)	NC score	0.014047 (rank : 153)
Query Neighborhood Hits	170	Target Neighborhood Hits	126	Shared Neighborhood Hits	6
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

PERF_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.111725 (rank : 124)
Query Neighborhood Hits	170	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

PLCD1_HUMAN
θ value	3.0926 (rank : 129)	NC score	0.110793 (rank : 126)
Query Neighborhood Hits	170	Target Neighborhood Hits	93	Shared Neighborhood Hits	56
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PO2F3_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.005870 (rank : 171)
Query Neighborhood Hits	170	Target Neighborhood Hits	319	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKI9, Q9UKR7, Q9Y504	Gene names	POU2F3, OTF11, PLA1
Domain Architecture
Description	POU domain, class 2, transcription factor 3 (Octamer-binding transcription factor 11) (Oct-11) (Transcription factor Skn-1) (PLA-1 protein).

RIMS3_MOUSE
θ value	3.0926 (rank : 131)	NC score	0.154952 (rank : 108)
Query Neighborhood Hits	170	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SYP2L_MOUSE
θ value	3.0926 (rank : 132)	NC score	0.012590 (rank : 155)
Query Neighborhood Hits	170	Target Neighborhood Hits	289	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SYT12_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.300249 (rank : 55)
Query Neighborhood Hits	170	Target Neighborhood Hits	102	Shared Neighborhood Hits	92
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

DMD_MOUSE
θ value	4.03905 (rank : 134)	NC score	0.010985 (rank : 161)
Query Neighborhood Hits	170	Target Neighborhood Hits	1111	Shared Neighborhood Hits	21
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

EHMT2_MOUSE
θ value	4.03905 (rank : 135)	NC score	0.005485 (rank : 173)
Query Neighborhood Hits	170	Target Neighborhood Hits	750	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

IF4G3_HUMAN
θ value	4.03905 (rank : 136)	NC score	0.011804 (rank : 157)
Query Neighborhood Hits	170	Target Neighborhood Hits	247	Shared Neighborhood Hits	8
SwissProt Accessions	O43432, Q15597, Q8NEN1	Gene names	EIF4G3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

PA24E_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.166592 (rank : 101)
Query Neighborhood Hits	170	Target Neighborhood Hits	89	Shared Neighborhood Hits	79
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

SYT13_MOUSE
θ value	4.03905 (rank : 138)	NC score	0.249901 (rank : 65)
Query Neighborhood Hits	170	Target Neighborhood Hits	69	Shared Neighborhood Hits	64
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT15_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.290669 (rank : 60)
Query Neighborhood Hits	170	Target Neighborhood Hits	112	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

COX1_MOUSE
θ value	5.27518 (rank : 140)	NC score	0.020311 (rank : 147)
Query Neighborhood Hits	170	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P00397	Gene names	Mtco1, COI, mt-Co1
Domain Architecture
Description	Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I).

RASA2_MOUSE
θ value	5.27518 (rank : 141)	NC score	0.222778 (rank : 73)
Query Neighborhood Hits	170	Target Neighborhood Hits	159	Shared Neighborhood Hits	82
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SET1A_HUMAN
θ value	5.27518 (rank : 142)	NC score	0.017149 (rank : 149)
Query Neighborhood Hits	170	Target Neighborhood Hits	690	Shared Neighborhood Hits	18
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

ITCH_MOUSE
θ value	6.88961 (rank : 143)	NC score	0.049162 (rank : 137)
Query Neighborhood Hits	170	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

MIA2_MOUSE
θ value	6.88961 (rank : 144)	NC score	0.025895 (rank : 142)
Query Neighborhood Hits	170	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MYBB_MOUSE
θ value	6.88961 (rank : 145)	NC score	0.011919 (rank : 156)
Query Neighborhood Hits	170	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P48972	Gene names	Mybl2, Bmyb
Domain Architecture
Description	Myb-related protein B (B-Myb).

NRX2A_HUMAN
θ value	6.88961 (rank : 146)	NC score	0.007624 (rank : 168)
Query Neighborhood Hits	170	Target Neighborhood Hits	614	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	6.88961 (rank : 147)	NC score	0.012608 (rank : 154)
Query Neighborhood Hits	170	Target Neighborhood Hits	481	Shared Neighborhood Hits	11
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PA24B_HUMAN
θ value	6.88961 (rank : 148)	NC score	0.151954 (rank : 109)
Query Neighborhood Hits	170	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24D_HUMAN
θ value	6.88961 (rank : 149)	NC score	0.209001 (rank : 84)
Query Neighborhood Hits	170	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PLCD1_MOUSE
θ value	6.88961 (rank : 150)	NC score	0.084278 (rank : 131)
Query Neighborhood Hits	170	Target Neighborhood Hits	106	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

RASA3_MOUSE
θ value	6.88961 (rank : 151)	NC score	0.170954 (rank : 99)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	72
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RIMS1_HUMAN
θ value	6.88961 (rank : 152)	NC score	0.226952 (rank : 69)
Query Neighborhood Hits	170	Target Neighborhood Hits	437	Shared Neighborhood Hits	95
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS3_HUMAN
θ value	6.88961 (rank : 153)	NC score	0.157154 (rank : 107)
Query Neighborhood Hits	170	Target Neighborhood Hits	66	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SC24C_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.010564 (rank : 164)
Query Neighborhood Hits	170	Target Neighborhood Hits	662	Shared Neighborhood Hits	14
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SYT12_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.291624 (rank : 59)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

ZP3_HUMAN
θ value	6.88961 (rank : 156)	NC score	0.014685 (rank : 150)
Query Neighborhood Hits	170	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	P21754, Q06633	Gene names	ZP3, ZP3A, ZPC
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Zona pellucida protein C) (Sperm receptor) (ZP3A/ZP3B).

AHR_MOUSE
θ value	8.99809 (rank : 157)	NC score	0.004479 (rank : 175)
Query Neighborhood Hits	170	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BCR_HUMAN
θ value	8.99809 (rank : 158)	NC score	0.022316 (rank : 145)
Query Neighborhood Hits	170	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

COBA1_HUMAN
θ value	8.99809 (rank : 159)	NC score	0.006428 (rank : 169)
Query Neighborhood Hits	170	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

DCDC2_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.010713 (rank : 162)
Query Neighborhood Hits	170	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UHG0, Q5VTR8, Q5VTR9, Q86W35, Q9UFD1, Q9ULR6	Gene names	DCDC2, KIAA1154
Domain Architecture
Description	Doublecortin domain-containing protein 2 (RU2S protein).

HIC1_MOUSE
θ value	8.99809 (rank : 161)	NC score	-0.004555 (rank : 177)
Query Neighborhood Hits	170	Target Neighborhood Hits	863	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

ITCH_HUMAN
θ value	8.99809 (rank : 162)	NC score	0.056407 (rank : 136)
Query Neighborhood Hits	170	Target Neighborhood Hits	162	Shared Neighborhood Hits	34
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

LTBP3_HUMAN
θ value	8.99809 (rank : 163)	NC score	-0.001102 (rank : 176)
Query Neighborhood Hits	170	Target Neighborhood Hits	502	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

NCOA6_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.020613 (rank : 146)
Query Neighborhood Hits	170	Target Neighborhood Hits	1202	Shared Neighborhood Hits	27
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NCPR_MOUSE
θ value	8.99809 (rank : 165)	NC score	0.005390 (rank : 174)
Query Neighborhood Hits	170	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P37040	Gene names	Por
Domain Architecture
Description	NADPH--cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R).

PA24E_MOUSE
θ value	8.99809 (rank : 166)	NC score	0.163822 (rank : 102)
Query Neighborhood Hits	170	Target Neighborhood Hits	95	Shared Neighborhood Hits	80
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PRG4_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.014294 (rank : 151)
Query Neighborhood Hits	170	Target Neighborhood Hits	764	Shared Neighborhood Hits	17
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RASA3_HUMAN
θ value	8.99809 (rank : 168)	NC score	0.193458 (rank : 92)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	80
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SYNE1_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.006314 (rank : 170)
Query Neighborhood Hits	170	Target Neighborhood Hits	1484	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TMM98_MOUSE
θ value	8.99809 (rank : 170)	NC score	0.010604 (rank : 163)
Query Neighborhood Hits	170	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q91X86	Gene names	Tmem98
Domain Architecture	No domain graphic available
Description	Transmembrane protein 98.

RASA1_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.058577 (rank : 134)
Query Neighborhood Hits	170	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASA2_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.207428 (rank : 85)
Query Neighborhood Hits	170	Target Neighborhood Hits	157	Shared Neighborhood Hits	82
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SYT14_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.217010 (rank : 79)
Query Neighborhood Hits	170	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.220064 (rank : 75)
Query Neighborhood Hits	170	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

TAC2N_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.112163 (rank : 123)
Query Neighborhood Hits	170	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.111173 (rank : 125)
Query Neighborhood Hits	170	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

WWC1_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.058179 (rank : 135)
Query Neighborhood Hits	170	Target Neighborhood Hits	290	Shared Neighborhood Hits	37
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

Hits sorted by NC score

DYSF_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	170	Target Neighborhood Hits	170	Shared Neighborhood Hits	170
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

DYSF_MOUSE
NC score	0.993568 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	170	Target Neighborhood Hits	162	Shared Neighborhood Hits	133
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

MYOF_HUMAN
NC score	0.980005 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	170	Target Neighborhood Hits	147	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

OTOF_HUMAN
NC score	0.916488 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	170	Target Neighborhood Hits	168	Shared Neighborhood Hits	102
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
NC score	0.914405 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	170	Target Neighborhood Hits	196	Shared Neighborhood Hits	102
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

FA62A_MOUSE
NC score	0.434746 (rank : 6)	θ value	3.77169e-06 (rank : 20)
Query Neighborhood Hits	170	Target Neighborhood Hits	155	Shared Neighborhood Hits	127
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

DOC2A_MOUSE
NC score	0.433727 (rank : 7)	θ value	2.44474e-05 (rank : 28)
Query Neighborhood Hits	170	Target Neighborhood Hits	140	Shared Neighborhood Hits	124
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
NC score	0.432146 (rank : 8)	θ value	7.59969e-07 (rank : 10)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	125
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

FA62A_HUMAN
NC score	0.431909 (rank : 9)	θ value	8.40245e-06 (rank : 25)
Query Neighborhood Hits	170	Target Neighborhood Hits	168	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

DOC2A_HUMAN
NC score	0.431437 (rank : 10)	θ value	3.19293e-05 (rank : 29)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	123
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

RASL1_HUMAN
NC score	0.431337 (rank : 11)	θ value	3.89403e-11 (rank : 6)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	108
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

DOC2B_MOUSE
NC score	0.430544 (rank : 12)	θ value	1.69304e-06 (rank : 12)
Query Neighborhood Hits	170	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

SYT3_MOUSE
NC score	0.424938 (rank : 13)	θ value	2.88788e-06 (rank : 19)
Query Neighborhood Hits	170	Target Neighborhood Hits	147	Shared Neighborhood Hits	122
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_HUMAN
NC score	0.424764 (rank : 14)	θ value	2.88788e-06 (rank : 18)
Query Neighborhood Hits	170	Target Neighborhood Hits	145	Shared Neighborhood Hits	122
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

RP3A_HUMAN
NC score	0.423226 (rank : 15)	θ value	1.69304e-06 (rank : 13)
Query Neighborhood Hits	170	Target Neighborhood Hits	305	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT10_MOUSE
NC score	0.422329 (rank : 16)	θ value	1.69304e-06 (rank : 14)
Query Neighborhood Hits	170	Target Neighborhood Hits	133	Shared Neighborhood Hits	122
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

RP3A_MOUSE
NC score	0.422185 (rank : 17)	θ value	3.77169e-06 (rank : 22)
Query Neighborhood Hits	170	Target Neighborhood Hits	510	Shared Neighborhood Hits	130
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT10_HUMAN
NC score	0.418166 (rank : 18)	θ value	2.88788e-06 (rank : 17)
Query Neighborhood Hits	170	Target Neighborhood Hits	134	Shared Neighborhood Hits	122
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

RASL2_HUMAN
NC score	0.414723 (rank : 19)	θ value	7.59969e-07 (rank : 11)
Query Neighborhood Hits	170	Target Neighborhood Hits	161	Shared Neighborhood Hits	120
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RASL1_MOUSE
NC score	0.413804 (rank : 20)	θ value	3.29651e-10 (rank : 7)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

SYT6_MOUSE
NC score	0.413780 (rank : 21)	θ value	1.69304e-06 (rank : 16)
Query Neighborhood Hits	170	Target Neighborhood Hits	132	Shared Neighborhood Hits	121
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_HUMAN
NC score	0.413389 (rank : 22)	θ value	1.69304e-06 (rank : 15)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	121
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT5_MOUSE
NC score	0.412898 (rank : 23)	θ value	9.29e-05 (rank : 37)
Query Neighborhood Hits	170	Target Neighborhood Hits	140	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT5_HUMAN
NC score	0.412256 (rank : 24)	θ value	9.29e-05 (rank : 36)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	125
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT9_HUMAN
NC score	0.410872 (rank : 25)	θ value	3.19293e-05 (rank : 30)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	122
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
NC score	0.410605 (rank : 26)	θ value	3.19293e-05 (rank : 31)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT7_HUMAN
NC score	0.408520 (rank : 27)	θ value	0.00298849 (rank : 52)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	123
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
NC score	0.406456 (rank : 28)	θ value	0.00509761 (rank : 55)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT1_HUMAN
NC score	0.406453 (rank : 29)	θ value	0.00134147 (rank : 48)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	125
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.406444 (rank : 30)	θ value	0.00134147 (rank : 49)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	125
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT2_MOUSE
NC score	0.404293 (rank : 31)	θ value	0.000602161 (rank : 42)
Query Neighborhood Hits	170	Target Neighborhood Hits	143	Shared Neighborhood Hits	125
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
NC score	0.403265 (rank : 32)	θ value	0.000602161 (rank : 41)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	125
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

DOC2G_MOUSE
NC score	0.402586 (rank : 33)	θ value	0.00665767 (rank : 56)
Query Neighborhood Hits	170	Target Neighborhood Hits	125	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYTL2_HUMAN
NC score	0.364827 (rank : 34)	θ value	0.00020696 (rank : 39)
Query Neighborhood Hits	170	Target Neighborhood Hits	248	Shared Neighborhood Hits	100
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
NC score	0.364455 (rank : 35)	θ value	0.000158464 (rank : 38)
Query Neighborhood Hits	170	Target Neighborhood Hits	253	Shared Neighborhood Hits	101
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYT4_HUMAN
NC score	0.362496 (rank : 36)	θ value	0.000461057 (rank : 40)
Query Neighborhood Hits	170	Target Neighborhood Hits	121	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT4_MOUSE
NC score	0.358583 (rank : 37)	θ value	0.00665767 (rank : 57)
Query Neighborhood Hits	170	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

UN13D_HUMAN
NC score	0.358265 (rank : 38)	θ value	0.0148317 (rank : 64)
Query Neighborhood Hits	170	Target Neighborhood Hits	117	Shared Neighborhood Hits	97
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

SYT11_MOUSE
NC score	0.357782 (rank : 39)	θ value	0.0113563 (rank : 61)
Query Neighborhood Hits	170	Target Neighborhood Hits	116	Shared Neighborhood Hits	104
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.356017 (rank : 40)	θ value	0.0148317 (rank : 62)
Query Neighborhood Hits	170	Target Neighborhood Hits	113	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

BAIP3_MOUSE
NC score	0.353708 (rank : 41)	θ value	0.00228821 (rank : 50)
Query Neighborhood Hits	170	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_HUMAN
NC score	0.351889 (rank : 42)	θ value	0.00134147 (rank : 46)
Query Neighborhood Hits	170	Target Neighborhood Hits	108	Shared Neighborhood Hits	87
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

SYTL1_HUMAN
NC score	0.347715 (rank : 43)	θ value	4.1701e-05 (rank : 33)
Query Neighborhood Hits	170	Target Neighborhood Hits	227	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL5_MOUSE
NC score	0.341067 (rank : 44)	θ value	0.163984 (rank : 88)
Query Neighborhood Hits	170	Target Neighborhood Hits	154	Shared Neighborhood Hits	111
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

K0528_HUMAN
NC score	0.338512 (rank : 45)	θ value	0.00102713 (rank : 44)
Query Neighborhood Hits	170	Target Neighborhood Hits	96	Shared Neighborhood Hits	84
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
NC score	0.338116 (rank : 46)	θ value	0.00102713 (rank : 45)
Query Neighborhood Hits	170	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

SYTL5_HUMAN
NC score	0.335761 (rank : 47)	θ value	0.125558 (rank : 86)
Query Neighborhood Hits	170	Target Neighborhood Hits	237	Shared Neighborhood Hits	113
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL4_MOUSE
NC score	0.326836 (rank : 48)	θ value	0.00665767 (rank : 58)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	95
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_HUMAN
NC score	0.326552 (rank : 49)	θ value	0.0148317 (rank : 63)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	93
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL1_MOUSE
NC score	0.325582 (rank : 50)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	170	Target Neighborhood Hits	314	Shared Neighborhood Hits	94
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

PCLO_HUMAN
NC score	0.321861 (rank : 51)	θ value	2.36244e-08 (rank : 8)
Query Neighborhood Hits	170	Target Neighborhood Hits	2046	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RFIP2_HUMAN
NC score	0.310386 (rank : 52)	θ value	0.0431538 (rank : 74)
Query Neighborhood Hits	170	Target Neighborhood Hits	97	Shared Neighborhood Hits	75
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

PCLO_MOUSE
NC score	0.303019 (rank : 53)	θ value	4.45536e-07 (rank : 9)
Query Neighborhood Hits	170	Target Neighborhood Hits	2275	Shared Neighborhood Hits	144
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYTL3_MOUSE
NC score	0.302362 (rank : 54)	θ value	0.0736092 (rank : 82)
Query Neighborhood Hits	170	Target Neighborhood Hits	110	Shared Neighborhood Hits	82
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYT12_MOUSE
NC score	0.300249 (rank : 55)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	170	Target Neighborhood Hits	102	Shared Neighborhood Hits	92
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

UN13A_HUMAN
NC score	0.298062 (rank : 56)	θ value	0.00228821 (rank : 51)
Query Neighborhood Hits	170	Target Neighborhood Hits	285	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_MOUSE
NC score	0.295565 (rank : 57)	θ value	0.00298849 (rank : 54)
Query Neighborhood Hits	170	Target Neighborhood Hits	210	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYT8_MOUSE
NC score	0.292505 (rank : 58)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	170	Target Neighborhood Hits	94	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT12_HUMAN
NC score	0.291624 (rank : 59)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT15_HUMAN
NC score	0.290669 (rank : 60)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	170	Target Neighborhood Hits	112	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT15_MOUSE
NC score	0.279784 (rank : 61)	θ value	1.38821 (rank : 113)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	90
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

UN13B_HUMAN
NC score	0.277489 (rank : 62)	θ value	0.00298849 (rank : 53)
Query Neighborhood Hits	170	Target Neighborhood Hits	217	Shared Neighborhood Hits	112
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYT13_HUMAN
NC score	0.261861 (rank : 63)	θ value	0.279714 (rank : 92)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

PA24D_MOUSE
NC score	0.259318 (rank : 64)	θ value	0.0736092 (rank : 81)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	92
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

SYT13_MOUSE
NC score	0.249901 (rank : 65)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	170	Target Neighborhood Hits	69	Shared Neighborhood Hits	64
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

RIMS2_HUMAN
NC score	0.244665 (rank : 66)	θ value	0.813845 (rank : 106)
Query Neighborhood Hits	170	Target Neighborhood Hits	342	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.242389 (rank : 67)	θ value	0.813845 (rank : 107)
Query Neighborhood Hits	170	Target Neighborhood Hits	376	Shared Neighborhood Hits	106
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

PA24B_MOUSE
NC score	0.227533 (rank : 68)	θ value	0.00134147 (rank : 47)
Query Neighborhood Hits	170	Target Neighborhood Hits	102	Shared Neighborhood Hits	83
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RIMS1_HUMAN
NC score	0.226952 (rank : 69)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	170	Target Neighborhood Hits	437	Shared Neighborhood Hits	95
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

CPNE3_MOUSE
NC score	0.225298 (rank : 70)	θ value	0.0736092 (rank : 78)
Query Neighborhood Hits	170	Target Neighborhood Hits	90	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE8_HUMAN
NC score	0.222916 (rank : 71)	θ value	0.0330416 (rank : 70)
Query Neighborhood Hits	170	Target Neighborhood Hits	86	Shared Neighborhood Hits	78
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE3_HUMAN
NC score	0.222838 (rank : 72)	θ value	0.0563607 (rank : 75)
Query Neighborhood Hits	170	Target Neighborhood Hits	90	Shared Neighborhood Hits	80
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

RASA2_MOUSE
NC score	0.222778 (rank : 73)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	170	Target Neighborhood Hits	159	Shared Neighborhood Hits	82
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CPNE5_MOUSE
NC score	0.220295 (rank : 74)	θ value	0.0736092 (rank : 80)
Query Neighborhood Hits	170	Target Neighborhood Hits	86	Shared Neighborhood Hits	78
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

SYT14_MOUSE
NC score	0.220064 (rank : 75)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	170	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

CPNE8_MOUSE
NC score	0.220055 (rank : 76)	θ value	0.0330416 (rank : 71)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	77
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE5_HUMAN
NC score	0.219920 (rank : 77)	θ value	0.0736092 (rank : 79)
Query Neighborhood Hits	170	Target Neighborhood Hits	88	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

NED4L_HUMAN
NC score	0.218489 (rank : 78)	θ value	0.00869519 (rank : 60)
Query Neighborhood Hits	170	Target Neighborhood Hits	238	Shared Neighborhood Hits	124
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SYT14_HUMAN
NC score	0.217010 (rank : 79)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	170	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

NED4L_MOUSE
NC score	0.214521 (rank : 80)	θ value	0.0563607 (rank : 76)
Query Neighborhood Hits	170	Target Neighborhood Hits	231	Shared Neighborhood Hits	122
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

CPNE2_MOUSE
NC score	0.211837 (rank : 81)	θ value	0.0193708 (rank : 65)
Query Neighborhood Hits	170	Target Neighborhood Hits	82	Shared Neighborhood Hits	74
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

NEDD4_HUMAN
NC score	0.211099 (rank : 82)	θ value	0.21417 (rank : 89)
Query Neighborhood Hits	170	Target Neighborhood Hits	214	Shared Neighborhood Hits	120
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
NC score	0.210197 (rank : 83)	θ value	0.0193708 (rank : 66)
Query Neighborhood Hits	170	Target Neighborhood Hits	212	Shared Neighborhood Hits	120
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PA24D_HUMAN
NC score	0.209001 (rank : 84)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	170	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RASA2_HUMAN
NC score	0.207428 (rank : 85)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	170	Target Neighborhood Hits	157	Shared Neighborhood Hits	82
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CPNE7_HUMAN
NC score	0.206437 (rank : 86)	θ value	0.00869519 (rank : 59)
Query Neighborhood Hits	170	Target Neighborhood Hits	92	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

CPNE2_HUMAN
NC score	0.202077 (rank : 87)	θ value	0.47712 (rank : 102)
Query Neighborhood Hits	170	Target Neighborhood Hits	75	Shared Neighborhood Hits	71
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE1_MOUSE
NC score	0.199122 (rank : 88)	θ value	0.365318 (rank : 93)
Query Neighborhood Hits	170	Target Neighborhood Hits	83	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

P3C2B_HUMAN
NC score	0.197320 (rank : 89)	θ value	0.0431538 (rank : 73)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	80
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

RIMS4_MOUSE
NC score	0.195810 (rank : 90)	θ value	0.365318 (rank : 99)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	70
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.194157 (rank : 91)	θ value	0.365318 (rank : 98)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RASA3_HUMAN
NC score	0.193458 (rank : 92)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	80
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

PA24A_MOUSE
NC score	0.193102 (rank : 93)	θ value	0.365318 (rank : 95)
Query Neighborhood Hits	170	Target Neighborhood Hits	100	Shared Neighborhood Hits	78
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

CPNE6_HUMAN
NC score	0.192667 (rank : 94)	θ value	0.0252991 (rank : 67)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
NC score	0.188286 (rank : 95)	θ value	0.125558 (rank : 85)
Query Neighborhood Hits	170	Target Neighborhood Hits	87	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

PA24A_HUMAN
NC score	0.187505 (rank : 96)	θ value	0.365318 (rank : 94)
Query Neighborhood Hits	170	Target Neighborhood Hits	88	Shared Neighborhood Hits	79
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

CPNE1_HUMAN
NC score	0.180604 (rank : 97)	θ value	0.163984 (rank : 87)
Query Neighborhood Hits	170	Target Neighborhood Hits	70	Shared Neighborhood Hits	69
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

ITSN2_HUMAN
NC score	0.178717 (rank : 98)	θ value	3.77169e-06 (rank : 21)
Query Neighborhood Hits	170	Target Neighborhood Hits	1173	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RASA3_MOUSE
NC score	0.170954 (rank : 99)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	72
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

ITSN2_MOUSE
NC score	0.166742 (rank : 100)	θ value	1.87187e-05 (rank : 27)
Query Neighborhood Hits	170	Target Neighborhood Hits	1371	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PA24E_HUMAN
NC score	0.166592 (rank : 101)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	170	Target Neighborhood Hits	89	Shared Neighborhood Hits	79
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24E_MOUSE
NC score	0.163822 (rank : 102)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	170	Target Neighborhood Hits	95	Shared Neighborhood Hits	80
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

CPNE4_HUMAN
NC score	0.162907 (rank : 103)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	170	Target Neighborhood Hits	70	Shared Neighborhood Hits	67
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
NC score	0.162067 (rank : 104)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	170	Target Neighborhood Hits	67	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

P3C2A_HUMAN
NC score	0.161077 (rank : 105)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	170	Target Neighborhood Hits	188	Shared Neighborhood Hits	75
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
NC score	0.159354 (rank : 106)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	170	Target Neighborhood Hits	181	Shared Neighborhood Hits	74
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

RIMS3_HUMAN
NC score	0.157154 (rank : 107)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	170	Target Neighborhood Hits	66	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
NC score	0.154952 (rank : 108)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	170	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

PA24B_HUMAN
NC score	0.151954 (rank : 109)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	170	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RFIP1_HUMAN
NC score	0.150491 (rank : 110)	θ value	0.0330416 (rank : 72)
Query Neighborhood Hits	170	Target Neighborhood Hits	236	Shared Neighborhood Hits	44
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

PA24F_HUMAN
NC score	0.143412 (rank : 111)	θ value	0.0961366 (rank : 84)
Query Neighborhood Hits	170	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PA24F_MOUSE
NC score	0.138862 (rank : 112)	θ value	0.365318 (rank : 96)
Query Neighborhood Hits	170	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

RFIP1_MOUSE
NC score	0.137396 (rank : 113)	θ value	0.365318 (rank : 97)
Query Neighborhood Hits	170	Target Neighborhood Hits	152	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

KPCG_MOUSE
NC score	0.136956 (rank : 114)	θ value	6.43352e-06 (rank : 24)
Query Neighborhood Hits	170	Target Neighborhood Hits	1123	Shared Neighborhood Hits	122
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.136573 (rank : 115)	θ value	8.40245e-06 (rank : 26)
Query Neighborhood Hits	170	Target Neighborhood Hits	1126	Shared Neighborhood Hits	123
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PERF_MOUSE
NC score	0.132434 (rank : 116)	θ value	0.0563607 (rank : 77)
Query Neighborhood Hits	170	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

KPCA_HUMAN
NC score	0.129433 (rank : 117)	θ value	4.92598e-06 (rank : 23)
Query Neighborhood Hits	170	Target Neighborhood Hits	1070	Shared Neighborhood Hits	126
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_MOUSE
NC score	0.129099 (rank : 118)	θ value	9.29e-05 (rank : 35)
Query Neighborhood Hits	170	Target Neighborhood Hits	1117	Shared Neighborhood Hits	123
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_HUMAN
NC score	0.127590 (rank : 119)	θ value	7.1131e-05 (rank : 34)
Query Neighborhood Hits	170	Target Neighborhood Hits	1121	Shared Neighborhood Hits	123
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_MOUSE
NC score	0.127185 (rank : 120)	θ value	4.1701e-05 (rank : 32)
Query Neighborhood Hits	170	Target Neighborhood Hits	1067	Shared Neighborhood Hits	126
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

ITSN1_MOUSE
NC score	0.120737 (rank : 121)	θ value	0.0252991 (rank : 69)
Query Neighborhood Hits	170	Target Neighborhood Hits	1669	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.119286 (rank : 122)	θ value	0.0252991 (rank : 68)
Query Neighborhood Hits	170	Target Neighborhood Hits	1757	Shared Neighborhood Hits	107
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

TAC2N_HUMAN
NC score	0.112163 (rank : 123)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	170	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

PERF_HUMAN
NC score	0.111725 (rank : 124)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	170	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

TAC2N_MOUSE
NC score	0.111173 (rank : 125)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	170	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

PLCD1_HUMAN
NC score	0.110793 (rank : 126)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	170	Target Neighborhood Hits	93	Shared Neighborhood Hits	56
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

SMUF1_HUMAN
NC score	0.105956 (rank : 127)	θ value	0.279714 (rank : 90)
Query Neighborhood Hits	170	Target Neighborhood Hits	135	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF2_HUMAN
NC score	0.105949 (rank : 128)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.104974 (rank : 129)	θ value	0.279714 (rank : 91)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

RGS3_HUMAN
NC score	0.095204 (rank : 130)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	170	Target Neighborhood Hits	1375	Shared Neighborhood Hits	88
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

PLCD1_MOUSE
NC score	0.084278 (rank : 131)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	170	Target Neighborhood Hits	106	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

P3C2G_MOUSE
NC score	0.063712 (rank : 132)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	170	Target Neighborhood Hits	113	Shared Neighborhood Hits	61
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

WWP1_MOUSE
NC score	0.062360 (rank : 133)	θ value	1.06291 (rank : 110)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

RASA1_HUMAN
NC score	0.058577 (rank : 134)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	170	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

WWC1_MOUSE
NC score	0.058179 (rank : 135)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	170	Target Neighborhood Hits	290	Shared Neighborhood Hits	37
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

ITCH_HUMAN
NC score	0.056407 (rank : 136)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	170	Target Neighborhood Hits	162	Shared Neighborhood Hits	34
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
NC score	0.049162 (rank : 137)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	170	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

RPGR1_HUMAN
NC score	0.034333 (rank : 138)	θ value	0.365318 (rank : 100)
Query Neighborhood Hits	170	Target Neighborhood Hits	578	Shared Neighborhood Hits	18
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

ASPP1_MOUSE
NC score	0.034018 (rank : 139)	θ value	0.0961366 (rank : 83)
Query Neighborhood Hits	170	Target Neighborhood Hits	1244	Shared Neighborhood Hits	23
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ARHGC_MOUSE
NC score	0.031764 (rank : 140)	θ value	3.0926 (rank : 120)
Query Neighborhood Hits	170	Target Neighborhood Hits	344	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MAVS_HUMAN
NC score	0.028070 (rank : 141)	θ value	1.06291 (rank : 109)
Query Neighborhood Hits	170	Target Neighborhood Hits	271	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MIA2_MOUSE
NC score	0.025895 (rank : 142)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	170	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

NCOA6_MOUSE
NC score	0.025645 (rank : 143)	θ value	0.62314 (rank : 105)
Query Neighborhood Hits	170	Target Neighborhood Hits	1076	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

HPS3_HUMAN
NC score	0.025180 (rank : 144)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	170	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q969F9, Q8WTV6, Q96AP1, Q96MR3, Q9H608	Gene names	HPS3
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 3 protein.

BCR_HUMAN
NC score	0.022316 (rank : 145)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	170	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

NCOA6_HUMAN
NC score	0.020613 (rank : 146)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	170	Target Neighborhood Hits	1202	Shared Neighborhood Hits	27
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

COX1_MOUSE
NC score	0.020311 (rank : 147)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	170	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P00397	Gene names	Mtco1, COI, mt-Co1
Domain Architecture
Description	Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I).

SYNJ2_HUMAN
NC score	0.019833 (rank : 148)	θ value	0.365318 (rank : 101)
Query Neighborhood Hits	170	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

SET1A_HUMAN
NC score	0.017149 (rank : 149)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	170	Target Neighborhood Hits	690	Shared Neighborhood Hits	18
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

ZP3_HUMAN
NC score	0.014685 (rank : 150)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	170	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	P21754, Q06633	Gene names	ZP3, ZP3A, ZPC
Domain Architecture
Description	Zona pellucida sperm-binding protein 3 precursor (Zona pellucida glycoprotein ZP3) (Zona pellucida protein C) (Sperm receptor) (ZP3A/ZP3B).

PRG4_HUMAN
NC score	0.014294 (rank : 151)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	170	Target Neighborhood Hits	764	Shared Neighborhood Hits	17
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

FLNB_HUMAN
NC score	0.014106 (rank : 152)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

FLNB_MOUSE
NC score	0.014047 (rank : 153)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	170	Target Neighborhood Hits	126	Shared Neighborhood Hits	6
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

NRX2B_HUMAN
NC score	0.012608 (rank : 154)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	170	Target Neighborhood Hits	481	Shared Neighborhood Hits	11
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

SYP2L_MOUSE
NC score	0.012590 (rank : 155)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	170	Target Neighborhood Hits	289	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

MYBB_MOUSE
NC score	0.011919 (rank : 156)	θ value	6.88961 (rank : 145)
Query Neighborhood Hits	170	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P48972	Gene names	Mybl2, Bmyb
Domain Architecture
Description	Myb-related protein B (B-Myb).

IF4G3_HUMAN
NC score	0.011804 (rank : 157)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	170	Target Neighborhood Hits	247	Shared Neighborhood Hits	8
SwissProt Accessions	O43432, Q15597, Q8NEN1	Gene names	EIF4G3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

COGA1_HUMAN
NC score	0.011596 (rank : 158)	θ value	3.0926 (rank : 121)
Query Neighborhood Hits	170	Target Neighborhood Hits	345	Shared Neighborhood Hits	15
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

ELK4_HUMAN
NC score	0.011354 (rank : 159)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	170	Target Neighborhood Hits	184	Shared Neighborhood Hits	8
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

CEL_HUMAN
NC score	0.011320 (rank : 160)	θ value	0.62314 (rank : 103)
Query Neighborhood Hits	170	Target Neighborhood Hits	896	Shared Neighborhood Hits	21
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

DMD_MOUSE
NC score	0.010985 (rank : 161)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	170	Target Neighborhood Hits	1111	Shared Neighborhood Hits	21
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DCDC2_HUMAN
NC score	0.010713 (rank : 162)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	170	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UHG0, Q5VTR8, Q5VTR9, Q86W35, Q9UFD1, Q9ULR6	Gene names	DCDC2, KIAA1154
Domain Architecture
Description	Doublecortin domain-containing protein 2 (RU2S protein).

TMM98_MOUSE
NC score	0.010604 (rank : 163)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	170	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q91X86	Gene names	Tmem98
Domain Architecture	No domain graphic available
Description	Transmembrane protein 98.

SC24C_HUMAN
NC score	0.010564 (rank : 164)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	170	Target Neighborhood Hits	662	Shared Neighborhood Hits	14
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

COBA1_MOUSE
NC score	0.009454 (rank : 165)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	170	Target Neighborhood Hits	487	Shared Neighborhood Hits	15
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CUTL2_HUMAN
NC score	0.008701 (rank : 166)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	170	Target Neighborhood Hits	906	Shared Neighborhood Hits	13
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

MACF4_HUMAN
NC score	0.008580 (rank : 167)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	170	Target Neighborhood Hits	1321	Shared Neighborhood Hits	18
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

NRX2A_HUMAN
NC score	0.007624 (rank : 168)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	170	Target Neighborhood Hits	614	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

COBA1_HUMAN
NC score	0.006428 (rank : 169)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	170	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

SYNE1_HUMAN
NC score	0.006314 (rank : 170)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	170	Target Neighborhood Hits	1484	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

PO2F3_HUMAN
NC score	0.005870 (rank : 171)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	170	Target Neighborhood Hits	319	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKI9, Q9UKR7, Q9Y504	Gene names	POU2F3, OTF11, PLA1
Domain Architecture
Description	POU domain, class 2, transcription factor 3 (Octamer-binding transcription factor 11) (Oct-11) (Transcription factor Skn-1) (PLA-1 protein).

GBX1_MOUSE
NC score	0.005811 (rank : 172)	θ value	0.62314 (rank : 104)
Query Neighborhood Hits	170	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P82976, Q8CGW5	Gene names	Gbx1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

EHMT2_MOUSE
NC score	0.005485 (rank : 173)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	170	Target Neighborhood Hits	750	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

NCPR_MOUSE
NC score	0.005390 (rank : 174)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	170	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P37040	Gene names	Por
Domain Architecture
Description	NADPH--cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R).

AHR_MOUSE
NC score	0.004479 (rank : 175)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	170	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

LTBP3_HUMAN
NC score	-0.001102 (rank : 176)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	170	Target Neighborhood Hits	502	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

HIC1_MOUSE
NC score	-0.004555 (rank : 177)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	170	Target Neighborhood Hits	863	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).