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Network neighborhood for query Sequence : SYTL4_MOUSE

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SYTL4_MOUSE
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYTL4_HUMAN
θ value	0 (rank : 1)	NC score	0.996674 (rank : 2)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	113
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	137	Target Neighborhood Hits	137	Shared Neighborhood Hits	137
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	3.06949e-141 (rank : 3)	NC score	0.970008 (rank : 4)
Query Neighborhood Hits	137	Target Neighborhood Hits	237	Shared Neighborhood Hits	105
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
θ value	5.8157e-124 (rank : 4)	NC score	0.970195 (rank : 3)
Query Neighborhood Hits	137	Target Neighborhood Hits	154	Shared Neighborhood Hits	102
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL2_MOUSE
θ value	3.45727e-76 (rank : 5)	NC score	0.923772 (rank : 7)
Query Neighborhood Hits	137	Target Neighborhood Hits	253	Shared Neighborhood Hits	101
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_HUMAN
θ value	1.11217e-74 (rank : 6)	NC score	0.919358 (rank : 9)
Query Neighborhood Hits	137	Target Neighborhood Hits	248	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL1_MOUSE
θ value	2.24614e-67 (rank : 7)	NC score	0.920608 (rank : 8)
Query Neighborhood Hits	137	Target Neighborhood Hits	314	Shared Neighborhood Hits	93
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL1_HUMAN
θ value	1.04338e-64 (rank : 8)	NC score	0.941828 (rank : 6)
Query Neighborhood Hits	137	Target Neighborhood Hits	227	Shared Neighborhood Hits	98
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL3_MOUSE
θ value	2.84797e-54 (rank : 9)	NC score	0.949628 (rank : 5)
Query Neighborhood Hits	137	Target Neighborhood Hits	110	Shared Neighborhood Hits	93
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYT2_MOUSE
θ value	2.12192e-33 (rank : 10)	NC score	0.847125 (rank : 15)
Query Neighborhood Hits	137	Target Neighborhood Hits	143	Shared Neighborhood Hits	98
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_HUMAN
θ value	6.17384e-33 (rank : 11)	NC score	0.847390 (rank : 14)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_MOUSE
θ value	1.37539e-32 (rank : 12)	NC score	0.846829 (rank : 16)
Query Neighborhood Hits	137	Target Neighborhood Hits	140	Shared Neighborhood Hits	98
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT5_HUMAN
θ value	1.16434e-31 (rank : 13)	NC score	0.845701 (rank : 17)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	98
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

DOC2B_MOUSE
θ value	3.3877e-31 (rank : 14)	NC score	0.851276 (rank : 10)
Query Neighborhood Hits	137	Target Neighborhood Hits	169	Shared Neighborhood Hits	96
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_HUMAN
θ value	9.8567e-31 (rank : 15)	NC score	0.850564 (rank : 11)
Query Neighborhood Hits	137	Target Neighborhood Hits	150	Shared Neighborhood Hits	96
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RP3A_MOUSE
θ value	1.28732e-30 (rank : 16)	NC score	0.827225 (rank : 31)
Query Neighborhood Hits	137	Target Neighborhood Hits	510	Shared Neighborhood Hits	103
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_HUMAN
θ value	8.3442e-30 (rank : 17)	NC score	0.835480 (rank : 24)
Query Neighborhood Hits	137	Target Neighborhood Hits	305	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT1_HUMAN
θ value	1.08979e-29 (rank : 18)	NC score	0.839770 (rank : 22)
Query Neighborhood Hits	137	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	1.08979e-29 (rank : 19)	NC score	0.839745 (rank : 23)
Query Neighborhood Hits	137	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT10_HUMAN
θ value	1.85889e-29 (rank : 20)	NC score	0.826575 (rank : 33)
Query Neighborhood Hits	137	Target Neighborhood Hits	134	Shared Neighborhood Hits	95
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT7_HUMAN
θ value	2.42779e-29 (rank : 21)	NC score	0.842894 (rank : 20)
Query Neighborhood Hits	137	Target Neighborhood Hits	137	Shared Neighborhood Hits	97
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT6_MOUSE
θ value	1.2049e-28 (rank : 22)	NC score	0.831451 (rank : 25)
Query Neighborhood Hits	137	Target Neighborhood Hits	132	Shared Neighborhood Hits	95
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT3_HUMAN
θ value	2.05525e-28 (rank : 23)	NC score	0.842916 (rank : 19)
Query Neighborhood Hits	137	Target Neighborhood Hits	145	Shared Neighborhood Hits	97
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT6_HUMAN
θ value	2.05525e-28 (rank : 24)	NC score	0.830940 (rank : 26)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	95
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT7_MOUSE
θ value	5.97985e-28 (rank : 25)	NC score	0.844047 (rank : 18)
Query Neighborhood Hits	137	Target Neighborhood Hits	137	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

DOC2A_MOUSE
θ value	1.02001e-27 (rank : 26)	NC score	0.849348 (rank : 12)
Query Neighborhood Hits	137	Target Neighborhood Hits	140	Shared Neighborhood Hits	94
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

SYT3_MOUSE
θ value	1.33217e-27 (rank : 27)	NC score	0.842233 (rank : 21)
Query Neighborhood Hits	137	Target Neighborhood Hits	147	Shared Neighborhood Hits	97
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT10_MOUSE
θ value	2.27234e-27 (rank : 28)	NC score	0.823431 (rank : 37)
Query Neighborhood Hits	137	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2A_HUMAN
θ value	6.61148e-27 (rank : 29)	NC score	0.849046 (rank : 13)
Query Neighborhood Hits	137	Target Neighborhood Hits	144	Shared Neighborhood Hits	95
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

SYT9_HUMAN
θ value	1.24688e-25 (rank : 30)	NC score	0.824842 (rank : 35)
Query Neighborhood Hits	137	Target Neighborhood Hits	144	Shared Neighborhood Hits	96
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	2.12685e-25 (rank : 31)	NC score	0.822595 (rank : 38)
Query Neighborhood Hits	137	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT4_MOUSE
θ value	2.20094e-22 (rank : 32)	NC score	0.828772 (rank : 30)
Query Neighborhood Hits	137	Target Neighborhood Hits	123	Shared Neighborhood Hits	92
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT4_HUMAN
θ value	3.75424e-22 (rank : 33)	NC score	0.830925 (rank : 27)
Query Neighborhood Hits	137	Target Neighborhood Hits	121	Shared Neighborhood Hits	92
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT11_HUMAN
θ value	1.2077e-20 (rank : 34)	NC score	0.829913 (rank : 28)
Query Neighborhood Hits	137	Target Neighborhood Hits	113	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	1.5773e-20 (rank : 35)	NC score	0.829834 (rank : 29)
Query Neighborhood Hits	137	Target Neighborhood Hits	116	Shared Neighborhood Hits	93
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT12_MOUSE
θ value	1.33526e-19 (rank : 36)	NC score	0.826841 (rank : 32)
Query Neighborhood Hits	137	Target Neighborhood Hits	102	Shared Neighborhood Hits	81
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

DOC2G_MOUSE
θ value	2.27762e-19 (rank : 37)	NC score	0.825507 (rank : 34)
Query Neighborhood Hits	137	Target Neighborhood Hits	125	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT12_HUMAN
θ value	2.27762e-19 (rank : 38)	NC score	0.824581 (rank : 36)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

PCLO_HUMAN
θ value	3.28887e-18 (rank : 39)	NC score	0.515533 (rank : 54)
Query Neighborhood Hits	137	Target Neighborhood Hits	2046	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYT8_MOUSE
θ value	1.24977e-17 (rank : 40)	NC score	0.813984 (rank : 39)
Query Neighborhood Hits	137	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT15_HUMAN
θ value	2.35696e-16 (rank : 41)	NC score	0.807990 (rank : 40)
Query Neighborhood Hits	137	Target Neighborhood Hits	112	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

PCLO_MOUSE
θ value	1.52774e-15 (rank : 42)	NC score	0.486276 (rank : 56)
Query Neighborhood Hits	137	Target Neighborhood Hits	2275	Shared Neighborhood Hits	107
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

MELPH_HUMAN
θ value	8.38298e-14 (rank : 43)	NC score	0.349531 (rank : 73)
Query Neighborhood Hits	137	Target Neighborhood Hits	145	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

P3C2A_HUMAN
θ value	1.42992e-13 (rank : 44)	NC score	0.471976 (rank : 58)
Query Neighborhood Hits	137	Target Neighborhood Hits	188	Shared Neighborhood Hits	74
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	1.42992e-13 (rank : 45)	NC score	0.470263 (rank : 59)
Query Neighborhood Hits	137	Target Neighborhood Hits	181	Shared Neighborhood Hits	75
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

RIMS1_HUMAN
θ value	9.26847e-13 (rank : 46)	NC score	0.594376 (rank : 48)
Query Neighborhood Hits	137	Target Neighborhood Hits	437	Shared Neighborhood Hits	87
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

MYRIP_MOUSE
θ value	3.52202e-12 (rank : 47)	NC score	0.354662 (rank : 71)
Query Neighborhood Hits	137	Target Neighborhood Hits	207	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

RIMS2_HUMAN
θ value	3.52202e-12 (rank : 48)	NC score	0.588967 (rank : 49)
Query Neighborhood Hits	137	Target Neighborhood Hits	342	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	3.52202e-12 (rank : 49)	NC score	0.581987 (rank : 50)
Query Neighborhood Hits	137	Target Neighborhood Hits	376	Shared Neighborhood Hits	97
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SYT15_MOUSE
θ value	4.59992e-12 (rank : 50)	NC score	0.773317 (rank : 41)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

MYRIP_HUMAN
θ value	6.00763e-12 (rank : 51)	NC score	0.343979 (rank : 74)
Query Neighborhood Hits	137	Target Neighborhood Hits	269	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

P3C2B_HUMAN
θ value	7.84624e-12 (rank : 52)	NC score	0.507899 (rank : 55)
Query Neighborhood Hits	137	Target Neighborhood Hits	148	Shared Neighborhood Hits	81
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

MELPH_MOUSE
θ value	1.02475e-11 (rank : 53)	NC score	0.350045 (rank : 72)
Query Neighborhood Hits	137	Target Neighborhood Hits	112	Shared Neighborhood Hits	24
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

KPCA_HUMAN
θ value	2.28291e-11 (rank : 54)	NC score	0.194123 (rank : 97)
Query Neighborhood Hits	137	Target Neighborhood Hits	1070	Shared Neighborhood Hits	98
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	5.08577e-11 (rank : 55)	NC score	0.191171 (rank : 100)
Query Neighborhood Hits	137	Target Neighborhood Hits	1067	Shared Neighborhood Hits	98
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCG_HUMAN
θ value	1.47974e-10 (rank : 56)	NC score	0.208982 (rank : 94)
Query Neighborhood Hits	137	Target Neighborhood Hits	1126	Shared Neighborhood Hits	100
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	1.47974e-10 (rank : 57)	NC score	0.208516 (rank : 95)
Query Neighborhood Hits	137	Target Neighborhood Hits	1123	Shared Neighborhood Hits	99
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCB_MOUSE
θ value	2.52405e-10 (rank : 58)	NC score	0.192765 (rank : 98)
Query Neighborhood Hits	137	Target Neighborhood Hits	1117	Shared Neighborhood Hits	96
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

RASA2_HUMAN
θ value	2.13673e-09 (rank : 59)	NC score	0.414657 (rank : 69)
Query Neighborhood Hits	137	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

KPCB_HUMAN
θ value	2.79066e-09 (rank : 60)	NC score	0.189916 (rank : 101)
Query Neighborhood Hits	137	Target Neighborhood Hits	1121	Shared Neighborhood Hits	97
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

RASA2_MOUSE
θ value	3.08544e-08 (rank : 61)	NC score	0.421680 (rank : 68)
Query Neighborhood Hits	137	Target Neighborhood Hits	159	Shared Neighborhood Hits	78
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

FA62A_MOUSE
θ value	5.81887e-07 (rank : 62)	NC score	0.625574 (rank : 46)
Query Neighborhood Hits	137	Target Neighborhood Hits	155	Shared Neighborhood Hits	98
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT14_MOUSE
θ value	5.81887e-07 (rank : 63)	NC score	0.660901 (rank : 44)
Query Neighborhood Hits	137	Target Neighborhood Hits	82	Shared Neighborhood Hits	62
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

FA62A_HUMAN
θ value	9.92553e-07 (rank : 64)	NC score	0.624298 (rank : 47)
Query Neighborhood Hits	137	Target Neighborhood Hits	168	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RASL2_HUMAN
θ value	1.29631e-06 (rank : 65)	NC score	0.555856 (rank : 51)
Query Neighborhood Hits	137	Target Neighborhood Hits	161	Shared Neighborhood Hits	89
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

SYT14_HUMAN
θ value	2.21117e-06 (rank : 66)	NC score	0.660563 (rank : 45)
Query Neighborhood Hits	137	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

RIMS3_MOUSE
θ value	4.1701e-05 (rank : 67)	NC score	0.442672 (rank : 63)
Query Neighborhood Hits	137	Target Neighborhood Hits	67	Shared Neighborhood Hits	66
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

SYT13_HUMAN
θ value	4.1701e-05 (rank : 68)	NC score	0.678242 (rank : 42)
Query Neighborhood Hits	137	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

RIMS3_HUMAN
θ value	0.000121331 (rank : 69)	NC score	0.446971 (rank : 62)
Query Neighborhood Hits	137	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_MOUSE
θ value	0.000121331 (rank : 70)	NC score	0.528687 (rank : 52)
Query Neighborhood Hits	137	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
θ value	0.00020696 (rank : 71)	NC score	0.525070 (rank : 53)
Query Neighborhood Hits	137	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYT13_MOUSE
θ value	0.00020696 (rank : 72)	NC score	0.671500 (rank : 43)
Query Neighborhood Hits	137	Target Neighborhood Hits	69	Shared Neighborhood Hits	66
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

BAIP3_HUMAN
θ value	0.000602161 (rank : 73)	NC score	0.450616 (rank : 60)
Query Neighborhood Hits	137	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
θ value	0.00390308 (rank : 74)	NC score	0.449037 (rank : 61)
Query Neighborhood Hits	137	Target Neighborhood Hits	112	Shared Neighborhood Hits	76
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

DYSF_HUMAN
θ value	0.00665767 (rank : 75)	NC score	0.326836 (rank : 76)
Query Neighborhood Hits	137	Target Neighborhood Hits	170	Shared Neighborhood Hits	95
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

NED4L_MOUSE
θ value	0.00665767 (rank : 76)	NC score	0.295677 (rank : 83)
Query Neighborhood Hits	137	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

DYSF_MOUSE
θ value	0.0113563 (rank : 77)	NC score	0.326036 (rank : 77)
Query Neighborhood Hits	137	Target Neighborhood Hits	162	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

WWP1_HUMAN
θ value	0.0148317 (rank : 78)	NC score	0.047981 (rank : 152)
Query Neighborhood Hits	137	Target Neighborhood Hits	262	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ITSN2_HUMAN
θ value	0.0193708 (rank : 79)	NC score	0.159956 (rank : 110)
Query Neighborhood Hits	137	Target Neighborhood Hits	1173	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

K0528_HUMAN
θ value	0.0193708 (rank : 80)	NC score	0.431531 (rank : 65)
Query Neighborhood Hits	137	Target Neighborhood Hits	96	Shared Neighborhood Hits	74
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	0.0193708 (rank : 81)	NC score	0.430834 (rank : 66)
Query Neighborhood Hits	137	Target Neighborhood Hits	102	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

RGS3_HUMAN
θ value	0.0193708 (rank : 82)	NC score	0.215364 (rank : 93)
Query Neighborhood Hits	137	Target Neighborhood Hits	1375	Shared Neighborhood Hits	83
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ITSN2_MOUSE
θ value	0.0252991 (rank : 83)	NC score	0.143837 (rank : 121)
Query Neighborhood Hits	137	Target Neighborhood Hits	1371	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NED4L_HUMAN
θ value	0.0252991 (rank : 84)	NC score	0.299493 (rank : 82)
Query Neighborhood Hits	137	Target Neighborhood Hits	238	Shared Neighborhood Hits	93
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

WWP1_MOUSE
θ value	0.0252991 (rank : 85)	NC score	0.044530 (rank : 153)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

RASA3_HUMAN
θ value	0.0431538 (rank : 86)	NC score	0.391775 (rank : 70)
Query Neighborhood Hits	137	Target Neighborhood Hits	166	Shared Neighborhood Hits	79
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASL1_HUMAN
θ value	0.0431538 (rank : 87)	NC score	0.439391 (rank : 64)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	80
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

UN13D_HUMAN
θ value	0.0431538 (rank : 88)	NC score	0.473968 (rank : 57)
Query Neighborhood Hits	137	Target Neighborhood Hits	117	Shared Neighborhood Hits	79
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

ITPR3_HUMAN
θ value	0.0563607 (rank : 89)	NC score	0.017333 (rank : 166)
Query Neighborhood Hits	137	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

NEDD4_HUMAN
θ value	0.0563607 (rank : 90)	NC score	0.275411 (rank : 85)
Query Neighborhood Hits	137	Target Neighborhood Hits	214	Shared Neighborhood Hits	91
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

P3C2G_HUMAN
θ value	0.0563607 (rank : 91)	NC score	0.174385 (rank : 105)
Query Neighborhood Hits	137	Target Neighborhood Hits	92	Shared Neighborhood Hits	47
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

SLC2B_HUMAN
θ value	0.0563607 (rank : 92)	NC score	0.157176 (rank : 111)
Query Neighborhood Hits	137	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

P3C2G_MOUSE
θ value	0.0961366 (rank : 93)	NC score	0.197301 (rank : 96)
Query Neighborhood Hits	137	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

RASA3_MOUSE
θ value	0.0961366 (rank : 94)	NC score	0.329209 (rank : 75)
Query Neighborhood Hits	137	Target Neighborhood Hits	144	Shared Neighborhood Hits	71
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASL1_MOUSE
θ value	0.163984 (rank : 95)	NC score	0.426183 (rank : 67)
Query Neighborhood Hits	137	Target Neighborhood Hits	148	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

CPNE6_MOUSE
θ value	0.365318 (rank : 96)	NC score	0.114582 (rank : 127)
Query Neighborhood Hits	137	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE7_HUMAN
θ value	0.47712 (rank : 97)	NC score	0.150738 (rank : 117)
Query Neighborhood Hits	137	Target Neighborhood Hits	92	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

ITSN1_HUMAN
θ value	0.47712 (rank : 98)	NC score	0.110049 (rank : 130)
Query Neighborhood Hits	137	Target Neighborhood Hits	1757	Shared Neighborhood Hits	83
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.47712 (rank : 99)	NC score	0.110933 (rank : 129)
Query Neighborhood Hits	137	Target Neighborhood Hits	1669	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FGD4_MOUSE
θ value	0.62314 (rank : 100)	NC score	0.035201 (rank : 159)
Query Neighborhood Hits	137	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

NEDD4_MOUSE
θ value	0.62314 (rank : 101)	NC score	0.261413 (rank : 87)
Query Neighborhood Hits	137	Target Neighborhood Hits	212	Shared Neighborhood Hits	90
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

TGON2_HUMAN
θ value	0.62314 (rank : 102)	NC score	0.023125 (rank : 162)
Query Neighborhood Hits	137	Target Neighborhood Hits	1037	Shared Neighborhood Hits	16
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CPNE6_HUMAN
θ value	1.06291 (rank : 103)	NC score	0.115361 (rank : 126)
Query Neighborhood Hits	137	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

FGD1_HUMAN
θ value	1.06291 (rank : 104)	NC score	0.040217 (rank : 154)
Query Neighborhood Hits	137	Target Neighborhood Hits	367	Shared Neighborhood Hits	24
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	1.06291 (rank : 105)	NC score	0.039360 (rank : 155)
Query Neighborhood Hits	137	Target Neighborhood Hits	387	Shared Neighborhood Hits	25
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

NSD1_HUMAN
θ value	1.06291 (rank : 106)	NC score	0.019246 (rank : 164)
Query Neighborhood Hits	137	Target Neighborhood Hits	427	Shared Neighborhood Hits	10
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

FGD3_MOUSE
θ value	1.38821 (rank : 107)	NC score	0.035809 (rank : 157)
Query Neighborhood Hits	137	Target Neighborhood Hits	257	Shared Neighborhood Hits	19
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

CJ068_HUMAN
θ value	1.81305 (rank : 108)	NC score	0.020792 (rank : 163)
Query Neighborhood Hits	137	Target Neighborhood Hits	316	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

MYOF_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.319644 (rank : 79)
Query Neighborhood Hits	137	Target Neighborhood Hits	147	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

ATRX_MOUSE
θ value	2.36792 (rank : 110)	NC score	0.018897 (rank : 165)
Query Neighborhood Hits	137	Target Neighborhood Hits	682	Shared Neighborhood Hits	13
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

LHX4_HUMAN
θ value	2.36792 (rank : 111)	NC score	0.001300 (rank : 181)
Query Neighborhood Hits	137	Target Neighborhood Hits	455	Shared Neighborhood Hits	4
SwissProt Accessions	Q969G2, Q8NHE0, Q8TCJ1, Q8WWX2, Q969W2	Gene names	LHX4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

RFIP1_MOUSE
θ value	2.36792 (rank : 112)	NC score	0.146827 (rank : 120)
Query Neighborhood Hits	137	Target Neighborhood Hits	152	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

UN84A_MOUSE
θ value	2.36792 (rank : 113)	NC score	0.011059 (rank : 169)
Query Neighborhood Hits	137	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D666, Q80SU8, Q8BZ99, Q99P23	Gene names	Unc84a, Sun1
Domain Architecture	No domain graphic available
Description	Sad1/unc-84 protein-like 1 (Unc-84 homolog A).

ATRX_HUMAN
θ value	3.0926 (rank : 114)	NC score	0.015422 (rank : 167)
Query Neighborhood Hits	137	Target Neighborhood Hits	842	Shared Neighborhood Hits	17
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

PA24E_MOUSE
θ value	3.0926 (rank : 115)	NC score	0.185702 (rank : 102)
Query Neighborhood Hits	137	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

TTC16_HUMAN
θ value	3.0926 (rank : 116)	NC score	0.005776 (rank : 175)
Query Neighborhood Hits	137	Target Neighborhood Hits	417	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

FGD2_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.035541 (rank : 158)
Query Neighborhood Hits	137	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	4.03905 (rank : 118)	NC score	0.035878 (rank : 156)
Query Neighborhood Hits	137	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

LARP1_HUMAN
θ value	4.03905 (rank : 119)	NC score	0.012155 (rank : 168)
Query Neighborhood Hits	137	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

LHX4_MOUSE
θ value	4.03905 (rank : 120)	NC score	0.000785 (rank : 182)
Query Neighborhood Hits	137	Target Neighborhood Hits	457	Shared Neighborhood Hits	4
SwissProt Accessions	P53776, O08916, Q9R280	Gene names	Lhx4, Gsh-4, Gsh4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

RFIP1_HUMAN
θ value	4.03905 (rank : 121)	NC score	0.138242 (rank : 122)
Query Neighborhood Hits	137	Target Neighborhood Hits	236	Shared Neighborhood Hits	42
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

TRI34_MOUSE
θ value	4.03905 (rank : 122)	NC score	0.001307 (rank : 180)
Query Neighborhood Hits	137	Target Neighborhood Hits	332	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

FGD4_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.031807 (rank : 160)
Query Neighborhood Hits	137	Target Neighborhood Hits	219	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

KKCC2_MOUSE
θ value	5.27518 (rank : 124)	NC score	0.009944 (rank : 170)
Query Neighborhood Hits	137	Target Neighborhood Hits	855	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

UN13A_HUMAN
θ value	6.88961 (rank : 125)	NC score	0.253958 (rank : 89)
Query Neighborhood Hits	137	Target Neighborhood Hits	285	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

VPS11_HUMAN
θ value	6.88961 (rank : 126)	NC score	0.009661 (rank : 172)
Query Neighborhood Hits	137	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H270, Q8WY89, Q96EP8, Q9H6D9, Q9HCS6	Gene names	VPS11, RNF108
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11 (hVPS11) (RING finger protein 108).

VPS11_MOUSE
θ value	6.88961 (rank : 127)	NC score	0.009716 (rank : 171)
Query Neighborhood Hits	137	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q91W86, Q9DBX8	Gene names	Vps11
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11.

CEP63_HUMAN
θ value	8.99809 (rank : 128)	NC score	-0.000756 (rank : 184)
Query Neighborhood Hits	137	Target Neighborhood Hits	1005	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

FGD3_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.029241 (rank : 161)
Query Neighborhood Hits	137	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FHL2_MOUSE
θ value	8.99809 (rank : 130)	NC score	-0.000488 (rank : 183)
Query Neighborhood Hits	137	Target Neighborhood Hits	539	Shared Neighborhood Hits	5
SwissProt Accessions	O70433, P97448	Gene names	Fhl2
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3).

PCGF6_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.007802 (rank : 173)
Query Neighborhood Hits	137	Target Neighborhood Hits	178	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

PEPL_MOUSE
θ value	8.99809 (rank : 132)	NC score	-0.001375 (rank : 185)
Query Neighborhood Hits	137	Target Neighborhood Hits	1105	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

RNF4_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.004981 (rank : 176)
Query Neighborhood Hits	137	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
θ value	8.99809 (rank : 134)	NC score	0.004941 (rank : 177)
Query Neighborhood Hits	137	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

SPRM1_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.001389 (rank : 178)
Query Neighborhood Hits	137	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N7G0, Q8N748	Gene names	SPRM1
Domain Architecture
Description	Sperm 1 POU-domain transcription factor (SPRM-1).

TRI32_MOUSE
θ value	8.99809 (rank : 136)	NC score	0.001318 (rank : 179)
Query Neighborhood Hits	137	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

UN84A_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.006936 (rank : 174)
Query Neighborhood Hits	137	Target Neighborhood Hits	206	Shared Neighborhood Hits	4
SwissProt Accessions	O94901, Q96CZ7, Q9HA14, Q9UH98	Gene names	UNC84A, KIAA0810, SUN1
Domain Architecture	No domain graphic available
Description	Sad1/unc-84 protein-like 1 (Unc-84 homolog A).

BSN_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.050701 (rank : 151)
Query Neighborhood Hits	137	Target Neighborhood Hits	1537	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CPNE1_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.130403 (rank : 123)
Query Neighborhood Hits	137	Target Neighborhood Hits	70	Shared Neighborhood Hits	50
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE1_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.155422 (rank : 113)
Query Neighborhood Hits	137	Target Neighborhood Hits	83	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.150995 (rank : 116)
Query Neighborhood Hits	137	Target Neighborhood Hits	75	Shared Neighborhood Hits	50
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.151895 (rank : 115)
Query Neighborhood Hits	137	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE3_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.178126 (rank : 103)
Query Neighborhood Hits	137	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE3_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.177139 (rank : 104)
Query Neighborhood Hits	137	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE4_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.098005 (rank : 133)
Query Neighborhood Hits	137	Target Neighborhood Hits	70	Shared Neighborhood Hits	46
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.094282 (rank : 137)
Query Neighborhood Hits	137	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE5_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.164659 (rank : 106)
Query Neighborhood Hits	137	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.164452 (rank : 107)
Query Neighborhood Hits	137	Target Neighborhood Hits	86	Shared Neighborhood Hits	56
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

CPNE8_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.156950 (rank : 112)
Query Neighborhood Hits	137	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE8_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.152956 (rank : 114)
Query Neighborhood Hits	137	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

OTOF_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.261904 (rank : 86)
Query Neighborhood Hits	137	Target Neighborhood Hits	168	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

OTOF_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.258840 (rank : 88)
Query Neighborhood Hits	137	Target Neighborhood Hits	196	Shared Neighborhood Hits	76
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

PA24A_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.150705 (rank : 118)
Query Neighborhood Hits	137	Target Neighborhood Hits	88	Shared Neighborhood Hits	64
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24A_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.164213 (rank : 108)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	64
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24B_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.148237 (rank : 119)
Query Neighborhood Hits	137	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24B_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.192558 (rank : 99)
Query Neighborhood Hits	137	Target Neighborhood Hits	102	Shared Neighborhood Hits	64
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24D_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.235060 (rank : 92)
Query Neighborhood Hits	137	Target Neighborhood Hits	97	Shared Neighborhood Hits	68
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PA24D_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.279492 (rank : 84)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

PA24E_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.161047 (rank : 109)
Query Neighborhood Hits	137	Target Neighborhood Hits	89	Shared Neighborhood Hits	61
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24F_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.096197 (rank : 136)
Query Neighborhood Hits	137	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PA24F_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.116323 (rank : 125)
Query Neighborhood Hits	137	Target Neighborhood Hits	93	Shared Neighborhood Hits	55
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PK3C3_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.051050 (rank : 149)
Query Neighborhood Hits	137	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.050898 (rank : 150)
Query Neighborhood Hits	137	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CA_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.057107 (rank : 143)
Query Neighborhood Hits	137	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.057126 (rank : 142)
Query Neighborhood Hits	137	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CB_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.054182 (rank : 148)
Query Neighborhood Hits	137	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.054199 (rank : 147)
Query Neighborhood Hits	137	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.054805 (rank : 144)
Query Neighborhood Hits	137	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.054741 (rank : 146)
Query Neighborhood Hits	137	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.058692 (rank : 140)
Query Neighborhood Hits	137	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.058600 (rank : 141)
Query Neighborhood Hits	137	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PLCD1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.122023 (rank : 124)
Query Neighborhood Hits	137	Target Neighborhood Hits	93	Shared Neighborhood Hits	50
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.082653 (rank : 138)
Query Neighborhood Hits	137	Target Neighborhood Hits	106	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

RASA1_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.054804 (rank : 145)
Query Neighborhood Hits	137	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RFIP2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.305024 (rank : 81)
Query Neighborhood Hits	137	Target Neighborhood Hits	97	Shared Neighborhood Hits	69
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

SMUF1_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.098564 (rank : 132)
Query Neighborhood Hits	137	Target Neighborhood Hits	135	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.097373 (rank : 134)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	51
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.096768 (rank : 135)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	53
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SYT8_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.112417 (rank : 128)
Query Neighborhood Hits	137	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NBV8, Q9NSV9	Gene names	SYT8
Domain Architecture	No domain graphic available
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

TAC2N_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.321685 (rank : 78)
Query Neighborhood Hits	137	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.318587 (rank : 80)
Query Neighborhood Hits	137	Target Neighborhood Hits	43	Shared Neighborhood Hits	36
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

UN13B_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.252286 (rank : 90)
Query Neighborhood Hits	137	Target Neighborhood Hits	217	Shared Neighborhood Hits	79
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.251841 (rank : 91)
Query Neighborhood Hits	137	Target Neighborhood Hits	210	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

WWC1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.073692 (rank : 139)
Query Neighborhood Hits	137	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.107418 (rank : 131)
Query Neighborhood Hits	137	Target Neighborhood Hits	290	Shared Neighborhood Hits	31
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

Hits sorted by NC score

SYTL4_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	137	Target Neighborhood Hits	137	Shared Neighborhood Hits	137
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_HUMAN
NC score	0.996674 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	113
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_MOUSE
NC score	0.970195 (rank : 3)	θ value	5.8157e-124 (rank : 4)
Query Neighborhood Hits	137	Target Neighborhood Hits	154	Shared Neighborhood Hits	102
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_HUMAN
NC score	0.970008 (rank : 4)	θ value	3.06949e-141 (rank : 3)
Query Neighborhood Hits	137	Target Neighborhood Hits	237	Shared Neighborhood Hits	105
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL3_MOUSE
NC score	0.949628 (rank : 5)	θ value	2.84797e-54 (rank : 9)
Query Neighborhood Hits	137	Target Neighborhood Hits	110	Shared Neighborhood Hits	93
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL1_HUMAN
NC score	0.941828 (rank : 6)	θ value	1.04338e-64 (rank : 8)
Query Neighborhood Hits	137	Target Neighborhood Hits	227	Shared Neighborhood Hits	98
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL2_MOUSE
NC score	0.923772 (rank : 7)	θ value	3.45727e-76 (rank : 5)
Query Neighborhood Hits	137	Target Neighborhood Hits	253	Shared Neighborhood Hits	101
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL1_MOUSE
NC score	0.920608 (rank : 8)	θ value	2.24614e-67 (rank : 7)
Query Neighborhood Hits	137	Target Neighborhood Hits	314	Shared Neighborhood Hits	93
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
NC score	0.919358 (rank : 9)	θ value	1.11217e-74 (rank : 6)
Query Neighborhood Hits	137	Target Neighborhood Hits	248	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

DOC2B_MOUSE
NC score	0.851276 (rank : 10)	θ value	3.3877e-31 (rank : 14)
Query Neighborhood Hits	137	Target Neighborhood Hits	169	Shared Neighborhood Hits	96
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_HUMAN
NC score	0.850564 (rank : 11)	θ value	9.8567e-31 (rank : 15)
Query Neighborhood Hits	137	Target Neighborhood Hits	150	Shared Neighborhood Hits	96
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_MOUSE
NC score	0.849348 (rank : 12)	θ value	1.02001e-27 (rank : 26)
Query Neighborhood Hits	137	Target Neighborhood Hits	140	Shared Neighborhood Hits	94
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2A_HUMAN
NC score	0.849046 (rank : 13)	θ value	6.61148e-27 (rank : 29)
Query Neighborhood Hits	137	Target Neighborhood Hits	144	Shared Neighborhood Hits	95
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

SYT2_HUMAN
NC score	0.847390 (rank : 14)	θ value	6.17384e-33 (rank : 11)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
NC score	0.847125 (rank : 15)	θ value	2.12192e-33 (rank : 10)
Query Neighborhood Hits	137	Target Neighborhood Hits	143	Shared Neighborhood Hits	98
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_MOUSE
NC score	0.846829 (rank : 16)	θ value	1.37539e-32 (rank : 12)
Query Neighborhood Hits	137	Target Neighborhood Hits	140	Shared Neighborhood Hits	98
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT5_HUMAN
NC score	0.845701 (rank : 17)	θ value	1.16434e-31 (rank : 13)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	98
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT7_MOUSE
NC score	0.844047 (rank : 18)	θ value	5.97985e-28 (rank : 25)
Query Neighborhood Hits	137	Target Neighborhood Hits	137	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT3_HUMAN
NC score	0.842916 (rank : 19)	θ value	2.05525e-28 (rank : 23)
Query Neighborhood Hits	137	Target Neighborhood Hits	145	Shared Neighborhood Hits	97
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT7_HUMAN
NC score	0.842894 (rank : 20)	θ value	2.42779e-29 (rank : 21)
Query Neighborhood Hits	137	Target Neighborhood Hits	137	Shared Neighborhood Hits	97
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT3_MOUSE
NC score	0.842233 (rank : 21)	θ value	1.33217e-27 (rank : 27)
Query Neighborhood Hits	137	Target Neighborhood Hits	147	Shared Neighborhood Hits	97
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT1_HUMAN
NC score	0.839770 (rank : 22)	θ value	1.08979e-29 (rank : 18)
Query Neighborhood Hits	137	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.839745 (rank : 23)	θ value	1.08979e-29 (rank : 19)
Query Neighborhood Hits	137	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

RP3A_HUMAN
NC score	0.835480 (rank : 24)	θ value	8.3442e-30 (rank : 17)
Query Neighborhood Hits	137	Target Neighborhood Hits	305	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT6_MOUSE
NC score	0.831451 (rank : 25)	θ value	1.2049e-28 (rank : 22)
Query Neighborhood Hits	137	Target Neighborhood Hits	132	Shared Neighborhood Hits	95
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_HUMAN
NC score	0.830940 (rank : 26)	θ value	2.05525e-28 (rank : 24)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	95
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT4_HUMAN
NC score	0.830925 (rank : 27)	θ value	3.75424e-22 (rank : 33)
Query Neighborhood Hits	137	Target Neighborhood Hits	121	Shared Neighborhood Hits	92
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT11_HUMAN
NC score	0.829913 (rank : 28)	θ value	1.2077e-20 (rank : 34)
Query Neighborhood Hits	137	Target Neighborhood Hits	113	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
NC score	0.829834 (rank : 29)	θ value	1.5773e-20 (rank : 35)
Query Neighborhood Hits	137	Target Neighborhood Hits	116	Shared Neighborhood Hits	93
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT4_MOUSE
NC score	0.828772 (rank : 30)	θ value	2.20094e-22 (rank : 32)
Query Neighborhood Hits	137	Target Neighborhood Hits	123	Shared Neighborhood Hits	92
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

RP3A_MOUSE
NC score	0.827225 (rank : 31)	θ value	1.28732e-30 (rank : 16)
Query Neighborhood Hits	137	Target Neighborhood Hits	510	Shared Neighborhood Hits	103
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT12_MOUSE
NC score	0.826841 (rank : 32)	θ value	1.33526e-19 (rank : 36)
Query Neighborhood Hits	137	Target Neighborhood Hits	102	Shared Neighborhood Hits	81
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT10_HUMAN
NC score	0.826575 (rank : 33)	θ value	1.85889e-29 (rank : 20)
Query Neighborhood Hits	137	Target Neighborhood Hits	134	Shared Neighborhood Hits	95
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

DOC2G_MOUSE
NC score	0.825507 (rank : 34)	θ value	2.27762e-19 (rank : 37)
Query Neighborhood Hits	137	Target Neighborhood Hits	125	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT9_HUMAN
NC score	0.824842 (rank : 35)	θ value	1.24688e-25 (rank : 30)
Query Neighborhood Hits	137	Target Neighborhood Hits	144	Shared Neighborhood Hits	96
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT12_HUMAN
NC score	0.824581 (rank : 36)	θ value	2.27762e-19 (rank : 38)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT10_MOUSE
NC score	0.823431 (rank : 37)	θ value	2.27234e-27 (rank : 28)
Query Neighborhood Hits	137	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT9_MOUSE
NC score	0.822595 (rank : 38)	θ value	2.12685e-25 (rank : 31)
Query Neighborhood Hits	137	Target Neighborhood Hits	148	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT8_MOUSE
NC score	0.813984 (rank : 39)	θ value	1.24977e-17 (rank : 40)
Query Neighborhood Hits	137	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT15_HUMAN
NC score	0.807990 (rank : 40)	θ value	2.35696e-16 (rank : 41)
Query Neighborhood Hits	137	Target Neighborhood Hits	112	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT15_MOUSE
NC score	0.773317 (rank : 41)	θ value	4.59992e-12 (rank : 50)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYT13_HUMAN
NC score	0.678242 (rank : 42)	θ value	4.1701e-05 (rank : 68)
Query Neighborhood Hits	137	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
NC score	0.671500 (rank : 43)	θ value	0.00020696 (rank : 72)
Query Neighborhood Hits	137	Target Neighborhood Hits	69	Shared Neighborhood Hits	66
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT14_MOUSE
NC score	0.660901 (rank : 44)	θ value	5.81887e-07 (rank : 63)
Query Neighborhood Hits	137	Target Neighborhood Hits	82	Shared Neighborhood Hits	62
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_HUMAN
NC score	0.660563 (rank : 45)	θ value	2.21117e-06 (rank : 66)
Query Neighborhood Hits	137	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

FA62A_MOUSE
NC score	0.625574 (rank : 46)	θ value	5.81887e-07 (rank : 62)
Query Neighborhood Hits	137	Target Neighborhood Hits	155	Shared Neighborhood Hits	98
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.624298 (rank : 47)	θ value	9.92553e-07 (rank : 64)
Query Neighborhood Hits	137	Target Neighborhood Hits	168	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
NC score	0.594376 (rank : 48)	θ value	9.26847e-13 (rank : 46)
Query Neighborhood Hits	137	Target Neighborhood Hits	437	Shared Neighborhood Hits	87
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
NC score	0.588967 (rank : 49)	θ value	3.52202e-12 (rank : 48)
Query Neighborhood Hits	137	Target Neighborhood Hits	342	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.581987 (rank : 50)	θ value	3.52202e-12 (rank : 49)
Query Neighborhood Hits	137	Target Neighborhood Hits	376	Shared Neighborhood Hits	97
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RASL2_HUMAN
NC score	0.555856 (rank : 51)	θ value	1.29631e-06 (rank : 65)
Query Neighborhood Hits	137	Target Neighborhood Hits	161	Shared Neighborhood Hits	89
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RIMS4_MOUSE
NC score	0.528687 (rank : 52)	θ value	0.000121331 (rank : 70)
Query Neighborhood Hits	137	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.525070 (rank : 53)	θ value	0.00020696 (rank : 71)
Query Neighborhood Hits	137	Target Neighborhood Hits	76	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

PCLO_HUMAN
NC score	0.515533 (rank : 54)	θ value	3.28887e-18 (rank : 39)
Query Neighborhood Hits	137	Target Neighborhood Hits	2046	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

P3C2B_HUMAN
NC score	0.507899 (rank : 55)	θ value	7.84624e-12 (rank : 52)
Query Neighborhood Hits	137	Target Neighborhood Hits	148	Shared Neighborhood Hits	81
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PCLO_MOUSE
NC score	0.486276 (rank : 56)	θ value	1.52774e-15 (rank : 42)
Query Neighborhood Hits	137	Target Neighborhood Hits	2275	Shared Neighborhood Hits	107
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

UN13D_HUMAN
NC score	0.473968 (rank : 57)	θ value	0.0431538 (rank : 88)
Query Neighborhood Hits	137	Target Neighborhood Hits	117	Shared Neighborhood Hits	79
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

P3C2A_HUMAN
NC score	0.471976 (rank : 58)	θ value	1.42992e-13 (rank : 44)
Query Neighborhood Hits	137	Target Neighborhood Hits	188	Shared Neighborhood Hits	74
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
NC score	0.470263 (rank : 59)	θ value	1.42992e-13 (rank : 45)
Query Neighborhood Hits	137	Target Neighborhood Hits	181	Shared Neighborhood Hits	75
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

BAIP3_HUMAN
NC score	0.450616 (rank : 60)	θ value	0.000602161 (rank : 73)
Query Neighborhood Hits	137	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
NC score	0.449037 (rank : 61)	θ value	0.00390308 (rank : 74)
Query Neighborhood Hits	137	Target Neighborhood Hits	112	Shared Neighborhood Hits	76
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

RIMS3_HUMAN
NC score	0.446971 (rank : 62)	θ value	0.000121331 (rank : 69)
Query Neighborhood Hits	137	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
NC score	0.442672 (rank : 63)	θ value	4.1701e-05 (rank : 67)
Query Neighborhood Hits	137	Target Neighborhood Hits	67	Shared Neighborhood Hits	66
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RASL1_HUMAN
NC score	0.439391 (rank : 64)	θ value	0.0431538 (rank : 87)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	80
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

K0528_HUMAN
NC score	0.431531 (rank : 65)	θ value	0.0193708 (rank : 80)
Query Neighborhood Hits	137	Target Neighborhood Hits	96	Shared Neighborhood Hits	74
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
NC score	0.430834 (rank : 66)	θ value	0.0193708 (rank : 81)
Query Neighborhood Hits	137	Target Neighborhood Hits	102	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

RASL1_MOUSE
NC score	0.426183 (rank : 67)	θ value	0.163984 (rank : 95)
Query Neighborhood Hits	137	Target Neighborhood Hits	148	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASA2_MOUSE
NC score	0.421680 (rank : 68)	θ value	3.08544e-08 (rank : 61)
Query Neighborhood Hits	137	Target Neighborhood Hits	159	Shared Neighborhood Hits	78
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_HUMAN
NC score	0.414657 (rank : 69)	θ value	2.13673e-09 (rank : 59)
Query Neighborhood Hits	137	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_HUMAN
NC score	0.391775 (rank : 70)	θ value	0.0431538 (rank : 86)
Query Neighborhood Hits	137	Target Neighborhood Hits	166	Shared Neighborhood Hits	79
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

MYRIP_MOUSE
NC score	0.354662 (rank : 71)	θ value	3.52202e-12 (rank : 47)
Query Neighborhood Hits	137	Target Neighborhood Hits	207	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

MELPH_MOUSE
NC score	0.350045 (rank : 72)	θ value	1.02475e-11 (rank : 53)
Query Neighborhood Hits	137	Target Neighborhood Hits	112	Shared Neighborhood Hits	24
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MELPH_HUMAN
NC score	0.349531 (rank : 73)	θ value	8.38298e-14 (rank : 43)
Query Neighborhood Hits	137	Target Neighborhood Hits	145	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MYRIP_HUMAN
NC score	0.343979 (rank : 74)	θ value	6.00763e-12 (rank : 51)
Query Neighborhood Hits	137	Target Neighborhood Hits	269	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

RASA3_MOUSE
NC score	0.329209 (rank : 75)	θ value	0.0961366 (rank : 94)
Query Neighborhood Hits	137	Target Neighborhood Hits	144	Shared Neighborhood Hits	71
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

DYSF_HUMAN
NC score	0.326836 (rank : 76)	θ value	0.00665767 (rank : 75)
Query Neighborhood Hits	137	Target Neighborhood Hits	170	Shared Neighborhood Hits	95
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

DYSF_MOUSE
NC score	0.326036 (rank : 77)	θ value	0.0113563 (rank : 77)
Query Neighborhood Hits	137	Target Neighborhood Hits	162	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

TAC2N_HUMAN
NC score	0.321685 (rank : 78)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	137	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

MYOF_HUMAN
NC score	0.319644 (rank : 79)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	137	Target Neighborhood Hits	147	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

TAC2N_MOUSE
NC score	0.318587 (rank : 80)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	137	Target Neighborhood Hits	43	Shared Neighborhood Hits	36
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

RFIP2_HUMAN
NC score	0.305024 (rank : 81)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	137	Target Neighborhood Hits	97	Shared Neighborhood Hits	69
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

NED4L_HUMAN
NC score	0.299493 (rank : 82)	θ value	0.0252991 (rank : 84)
Query Neighborhood Hits	137	Target Neighborhood Hits	238	Shared Neighborhood Hits	93
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.295677 (rank : 83)	θ value	0.00665767 (rank : 76)
Query Neighborhood Hits	137	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PA24D_MOUSE
NC score	0.279492 (rank : 84)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

NEDD4_HUMAN
NC score	0.275411 (rank : 85)	θ value	0.0563607 (rank : 90)
Query Neighborhood Hits	137	Target Neighborhood Hits	214	Shared Neighborhood Hits	91
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

OTOF_HUMAN
NC score	0.261904 (rank : 86)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	137	Target Neighborhood Hits	168	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

NEDD4_MOUSE
NC score	0.261413 (rank : 87)	θ value	0.62314 (rank : 101)
Query Neighborhood Hits	137	Target Neighborhood Hits	212	Shared Neighborhood Hits	90
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

OTOF_MOUSE
NC score	0.258840 (rank : 88)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	137	Target Neighborhood Hits	196	Shared Neighborhood Hits	76
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

UN13A_HUMAN
NC score	0.253958 (rank : 89)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	137	Target Neighborhood Hits	285	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
NC score	0.252286 (rank : 90)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	137	Target Neighborhood Hits	217	Shared Neighborhood Hits	79
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
NC score	0.251841 (rank : 91)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	137	Target Neighborhood Hits	210	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

PA24D_HUMAN
NC score	0.235060 (rank : 92)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	137	Target Neighborhood Hits	97	Shared Neighborhood Hits	68
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RGS3_HUMAN
NC score	0.215364 (rank : 93)	θ value	0.0193708 (rank : 82)
Query Neighborhood Hits	137	Target Neighborhood Hits	1375	Shared Neighborhood Hits	83
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

KPCG_HUMAN
NC score	0.208982 (rank : 94)	θ value	1.47974e-10 (rank : 56)
Query Neighborhood Hits	137	Target Neighborhood Hits	1126	Shared Neighborhood Hits	100
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
NC score	0.208516 (rank : 95)	θ value	1.47974e-10 (rank : 57)
Query Neighborhood Hits	137	Target Neighborhood Hits	1123	Shared Neighborhood Hits	99
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

P3C2G_MOUSE
NC score	0.197301 (rank : 96)	θ value	0.0961366 (rank : 93)
Query Neighborhood Hits	137	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

KPCA_HUMAN
NC score	0.194123 (rank : 97)	θ value	2.28291e-11 (rank : 54)
Query Neighborhood Hits	137	Target Neighborhood Hits	1070	Shared Neighborhood Hits	98
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_MOUSE
NC score	0.192765 (rank : 98)	θ value	2.52405e-10 (rank : 58)
Query Neighborhood Hits	137	Target Neighborhood Hits	1117	Shared Neighborhood Hits	96
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PA24B_MOUSE
NC score	0.192558 (rank : 99)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	137	Target Neighborhood Hits	102	Shared Neighborhood Hits	64
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

KPCA_MOUSE
NC score	0.191171 (rank : 100)	θ value	5.08577e-11 (rank : 55)
Query Neighborhood Hits	137	Target Neighborhood Hits	1067	Shared Neighborhood Hits	98
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
NC score	0.189916 (rank : 101)	θ value	2.79066e-09 (rank : 60)
Query Neighborhood Hits	137	Target Neighborhood Hits	1121	Shared Neighborhood Hits	97
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PA24E_MOUSE
NC score	0.185702 (rank : 102)	θ value	3.0926 (rank : 115)
Query Neighborhood Hits	137	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

CPNE3_HUMAN
NC score	0.178126 (rank : 103)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	137	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE3_MOUSE
NC score	0.177139 (rank : 104)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	137	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

P3C2G_HUMAN
NC score	0.174385 (rank : 105)	θ value	0.0563607 (rank : 91)
Query Neighborhood Hits	137	Target Neighborhood Hits	92	Shared Neighborhood Hits	47
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

CPNE5_HUMAN
NC score	0.164659 (rank : 106)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	137	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
NC score	0.164452 (rank : 107)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	137	Target Neighborhood Hits	86	Shared Neighborhood Hits	56
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

PA24A_MOUSE
NC score	0.164213 (rank : 108)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	137	Target Neighborhood Hits	100	Shared Neighborhood Hits	64
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24E_HUMAN
NC score	0.161047 (rank : 109)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	137	Target Neighborhood Hits	89	Shared Neighborhood Hits	61
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

ITSN2_HUMAN
NC score	0.159956 (rank : 110)	θ value	0.0193708 (rank : 79)
Query Neighborhood Hits	137	Target Neighborhood Hits	1173	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SLC2B_HUMAN
NC score	0.157176 (rank : 111)	θ value	0.0563607 (rank : 92)
Query Neighborhood Hits	137	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

CPNE8_HUMAN
NC score	0.156950 (rank : 112)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	137	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE1_MOUSE
NC score	0.155422 (rank : 113)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	137	Target Neighborhood Hits	83	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE8_MOUSE
NC score	0.152956 (rank : 114)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	137	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE2_MOUSE
NC score	0.151895 (rank : 115)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	137	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE2_HUMAN
NC score	0.150995 (rank : 116)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	137	Target Neighborhood Hits	75	Shared Neighborhood Hits	50
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

CPNE7_HUMAN
NC score	0.150738 (rank : 117)	θ value	0.47712 (rank : 97)
Query Neighborhood Hits	137	Target Neighborhood Hits	92	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

PA24A_HUMAN
NC score	0.150705 (rank : 118)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	137	Target Neighborhood Hits	88	Shared Neighborhood Hits	64
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24B_HUMAN
NC score	0.148237 (rank : 119)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	137	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RFIP1_MOUSE
NC score	0.146827 (rank : 120)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	137	Target Neighborhood Hits	152	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

ITSN2_MOUSE
NC score	0.143837 (rank : 121)	θ value	0.0252991 (rank : 83)
Query Neighborhood Hits	137	Target Neighborhood Hits	1371	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RFIP1_HUMAN
NC score	0.138242 (rank : 122)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	137	Target Neighborhood Hits	236	Shared Neighborhood Hits	42
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

CPNE1_HUMAN
NC score	0.130403 (rank : 123)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	137	Target Neighborhood Hits	70	Shared Neighborhood Hits	50
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

PLCD1_HUMAN
NC score	0.122023 (rank : 124)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	137	Target Neighborhood Hits	93	Shared Neighborhood Hits	50
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PA24F_MOUSE
NC score	0.116323 (rank : 125)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	137	Target Neighborhood Hits	93	Shared Neighborhood Hits	55
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

CPNE6_HUMAN
NC score	0.115361 (rank : 126)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	137	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
NC score	0.114582 (rank : 127)	θ value	0.365318 (rank : 96)
Query Neighborhood Hits	137	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

SYT8_HUMAN
NC score	0.112417 (rank : 128)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	137	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NBV8, Q9NSV9	Gene names	SYT8
Domain Architecture	No domain graphic available
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

ITSN1_MOUSE
NC score	0.110933 (rank : 129)	θ value	0.47712 (rank : 99)
Query Neighborhood Hits	137	Target Neighborhood Hits	1669	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.110049 (rank : 130)	θ value	0.47712 (rank : 98)
Query Neighborhood Hits	137	Target Neighborhood Hits	1757	Shared Neighborhood Hits	83
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

WWC1_MOUSE
NC score	0.107418 (rank : 131)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	137	Target Neighborhood Hits	290	Shared Neighborhood Hits	31
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

SMUF1_HUMAN
NC score	0.098564 (rank : 132)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	137	Target Neighborhood Hits	135	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

CPNE4_HUMAN
NC score	0.098005 (rank : 133)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	137	Target Neighborhood Hits	70	Shared Neighborhood Hits	46
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

SMUF1_MOUSE
NC score	0.097373 (rank : 134)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	51
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
NC score	0.096768 (rank : 135)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	137	Target Neighborhood Hits	142	Shared Neighborhood Hits	53
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

PA24F_HUMAN
NC score	0.096197 (rank : 136)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	137	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

CPNE4_MOUSE
NC score	0.094282 (rank : 137)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	137	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

PLCD1_MOUSE
NC score	0.082653 (rank : 138)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	137	Target Neighborhood Hits	106	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

WWC1_HUMAN
NC score	0.073692 (rank : 139)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	137	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

PK3CG_HUMAN
NC score	0.058692 (rank : 140)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	137	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.058600 (rank : 141)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	137	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CA_MOUSE
NC score	0.057126 (rank : 142)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	137	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_HUMAN
NC score	0.057107 (rank : 143)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	137	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CD_HUMAN
NC score	0.054805 (rank : 144)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	137	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

RASA1_HUMAN
NC score	0.054804 (rank : 145)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	137	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PK3CD_MOUSE
NC score	0.054741 (rank : 146)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	137	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_MOUSE
NC score	0.054199 (rank : 147)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	137	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.054182 (rank : 148)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	137	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3C3_HUMAN
NC score	0.051050 (rank : 149)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	137	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.050898 (rank : 150)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	137	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

BSN_HUMAN
NC score	0.050701 (rank : 151)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	137	Target Neighborhood Hits	1537	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

WWP1_HUMAN
NC score	0.047981 (rank : 152)	θ value	0.0148317 (rank : 78)
Query Neighborhood Hits	137	Target Neighborhood Hits	262	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
NC score	0.044530 (rank : 153)	θ value	0.0252991 (rank : 85)
Query Neighborhood Hits	137	Target Neighborhood Hits	138	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

FGD1_HUMAN
NC score	0.040217 (rank : 154)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	137	Target Neighborhood Hits	367	Shared Neighborhood Hits	24
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.039360 (rank : 155)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	137	Target Neighborhood Hits	387	Shared Neighborhood Hits	25
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
NC score	0.035878 (rank : 156)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	137	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_MOUSE
NC score	0.035809 (rank : 157)	θ value	1.38821 (rank : 107)
Query Neighborhood Hits	137	Target Neighborhood Hits	257	Shared Neighborhood Hits	19
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
NC score	0.035541 (rank : 158)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	137	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
NC score	0.035201 (rank : 159)	θ value	0.62314 (rank : 100)
Query Neighborhood Hits	137	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.031807 (rank : 160)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	137	Target Neighborhood Hits	219	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD3_HUMAN
NC score	0.029241 (rank : 161)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	137	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

TGON2_HUMAN
NC score	0.023125 (rank : 162)	θ value	0.62314 (rank : 102)
Query Neighborhood Hits	137	Target Neighborhood Hits	1037	Shared Neighborhood Hits	16
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CJ068_HUMAN
NC score	0.020792 (rank : 163)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	137	Target Neighborhood Hits	316	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

NSD1_HUMAN
NC score	0.019246 (rank : 164)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	137	Target Neighborhood Hits	427	Shared Neighborhood Hits	10
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

ATRX_MOUSE
NC score	0.018897 (rank : 165)	θ value	2.36792 (rank : 110)
Query Neighborhood Hits	137	Target Neighborhood Hits	682	Shared Neighborhood Hits	13
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

ITPR3_HUMAN
NC score	0.017333 (rank : 166)	θ value	0.0563607 (rank : 89)
Query Neighborhood Hits	137	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

ATRX_HUMAN
NC score	0.015422 (rank : 167)	θ value	3.0926 (rank : 114)
Query Neighborhood Hits	137	Target Neighborhood Hits	842	Shared Neighborhood Hits	17
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

LARP1_HUMAN
NC score	0.012155 (rank : 168)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	137	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

UN84A_MOUSE
NC score	0.011059 (rank : 169)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	137	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D666, Q80SU8, Q8BZ99, Q99P23	Gene names	Unc84a, Sun1
Domain Architecture	No domain graphic available
Description	Sad1/unc-84 protein-like 1 (Unc-84 homolog A).

KKCC2_MOUSE
NC score	0.009944 (rank : 170)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	137	Target Neighborhood Hits	855	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

VPS11_MOUSE
NC score	0.009716 (rank : 171)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	137	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q91W86, Q9DBX8	Gene names	Vps11
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11.

VPS11_HUMAN
NC score	0.009661 (rank : 172)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	137	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H270, Q8WY89, Q96EP8, Q9H6D9, Q9HCS6	Gene names	VPS11, RNF108
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11 (hVPS11) (RING finger protein 108).

PCGF6_HUMAN
NC score	0.007802 (rank : 173)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	137	Target Neighborhood Hits	178	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

UN84A_HUMAN
NC score	0.006936 (rank : 174)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	137	Target Neighborhood Hits	206	Shared Neighborhood Hits	4
SwissProt Accessions	O94901, Q96CZ7, Q9HA14, Q9UH98	Gene names	UNC84A, KIAA0810, SUN1
Domain Architecture	No domain graphic available
Description	Sad1/unc-84 protein-like 1 (Unc-84 homolog A).

TTC16_HUMAN
NC score	0.005776 (rank : 175)	θ value	3.0926 (rank : 116)
Query Neighborhood Hits	137	Target Neighborhood Hits	417	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

RNF4_HUMAN
NC score	0.004981 (rank : 176)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	137	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
NC score	0.004941 (rank : 177)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	137	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

SPRM1_HUMAN
NC score	0.001389 (rank : 178)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	137	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N7G0, Q8N748	Gene names	SPRM1
Domain Architecture
Description	Sperm 1 POU-domain transcription factor (SPRM-1).

TRI32_MOUSE
NC score	0.001318 (rank : 179)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	137	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI34_MOUSE
NC score	0.001307 (rank : 180)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	137	Target Neighborhood Hits	332	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

LHX4_HUMAN
NC score	0.001300 (rank : 181)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	137	Target Neighborhood Hits	455	Shared Neighborhood Hits	4
SwissProt Accessions	Q969G2, Q8NHE0, Q8TCJ1, Q8WWX2, Q969W2	Gene names	LHX4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

LHX4_MOUSE
NC score	0.000785 (rank : 182)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	137	Target Neighborhood Hits	457	Shared Neighborhood Hits	4
SwissProt Accessions	P53776, O08916, Q9R280	Gene names	Lhx4, Gsh-4, Gsh4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

FHL2_MOUSE
NC score	-0.000488 (rank : 183)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	137	Target Neighborhood Hits	539	Shared Neighborhood Hits	5
SwissProt Accessions	O70433, P97448	Gene names	Fhl2
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3).

CEP63_HUMAN
NC score	-0.000756 (rank : 184)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	137	Target Neighborhood Hits	1005	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

PEPL_MOUSE
NC score	-0.001375 (rank : 185)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	137	Target Neighborhood Hits	1105	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.