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Network neighborhood for query Sequence : PK3CA_HUMAN

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PK3CA_HUMAN
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PK3CA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	0 (rank : 2)	NC score	0.999669 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CB_HUMAN
θ value	0 (rank : 3)	NC score	0.979301 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	0 (rank : 4)	NC score	0.979181 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
θ value	0 (rank : 5)	NC score	0.981510 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	40	Shared Neighborhood Hits	29
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	0 (rank : 6)	NC score	0.981148 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_HUMAN
θ value	1.32836e-152 (rank : 7)	NC score	0.966483 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	1.46868e-151 (rank : 8)	NC score	0.966066 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

P3C2A_MOUSE
θ value	3.78717e-107 (rank : 9)	NC score	0.835068 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	1.43912e-106 (rank : 10)	NC score	0.811498 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2A_HUMAN
θ value	2.54029e-103 (rank : 11)	NC score	0.832490 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2G_MOUSE
θ value	1.76739e-88 (rank : 12)	NC score	0.907193 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
θ value	2.64101e-84 (rank : 13)	NC score	0.908151 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3C3_HUMAN
θ value	3.99248e-40 (rank : 14)	NC score	0.858057 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	1.16164e-39 (rank : 15)	NC score	0.856708 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	29
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PI4KA_HUMAN
θ value	1.08726e-37 (rank : 16)	NC score	0.830097 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PI4KB_HUMAN
θ value	2.77775e-25 (rank : 17)	NC score	0.776610 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	79	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	2.77775e-25 (rank : 18)	NC score	0.778891 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

FRAP_HUMAN
θ value	1.53129e-07 (rank : 19)	NC score	0.397926 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	1.53129e-07 (rank : 20)	NC score	0.399219 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATM_HUMAN
θ value	0.000158464 (rank : 21)	NC score	0.325151 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

PRKDC_MOUSE
θ value	0.000158464 (rank : 22)	NC score	0.367855 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
θ value	0.00020696 (rank : 23)	NC score	0.361526 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

ATM_MOUSE
θ value	0.000461057 (rank : 24)	NC score	0.314936 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATR_HUMAN
θ value	0.00175202 (rank : 25)	NC score	0.321949 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	0.00175202 (rank : 26)	NC score	0.320491 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

SMG1_HUMAN
θ value	0.00869519 (rank : 27)	NC score	0.265673 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	0.00869519 (rank : 28)	NC score	0.267877 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	212	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

LARP4_HUMAN
θ value	0.813845 (rank : 29)	NC score	0.029655 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q71RC2, Q5CZ97, Q96NF9	Gene names	LARP4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

AP4B1_MOUSE
θ value	1.06291 (rank : 30)	NC score	0.023607 (rank : 53)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.023046 (rank : 54)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

WASF3_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.028104 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	204	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

WASF3_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.027798 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

FBX46_MOUSE
θ value	1.81305 (rank : 34)	NC score	0.025381 (rank : 50)
Query Neighborhood Hits	45	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

NALP5_MOUSE
θ value	2.36792 (rank : 35)	NC score	0.004774 (rank : 61)
Query Neighborhood Hits	45	Target Neighborhood Hits	560	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

FBX46_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.024370 (rank : 51)
Query Neighborhood Hits	45	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PJ61	Gene names	FBXO46, FBX46, FBXO34L
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

VATB1_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.008563 (rank : 60)
Query Neighborhood Hits	45	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P15313	Gene names	ATP6V1B1, ATP6B1, VATB, VPP3
Domain Architecture
Description	Vacuolar ATP synthase subunit B, kidney isoform (EC 3.6.3.14) (V- ATPase B1 subunit) (Vacuolar proton pump B isoform 1) (Endomembrane proton pump 58 kDa subunit).

MLL3_MOUSE
θ value	5.27518 (rank : 38)	NC score	0.004030 (rank : 62)
Query Neighborhood Hits	45	Target Neighborhood Hits	1399	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

WASF1_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.018882 (rank : 55)
Query Neighborhood Hits	45	Target Neighborhood Hits	260	Shared Neighborhood Hits	9
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF1_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.018750 (rank : 56)
Query Neighborhood Hits	45	Target Neighborhood Hits	261	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

AP2B1_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.012527 (rank : 59)
Query Neighborhood Hits	45	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.012529 (rank : 58)
Query Neighborhood Hits	45	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

BUP1_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.024343 (rank : 52)
Query Neighborhood Hits	45	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UBR1, Q9UIR3	Gene names	UPB1, BUP1
Domain Architecture
Description	Beta-ureidopropionase (EC 3.5.1.6) (Beta-alanine synthase) (N- carbamoyl-beta-alanine amidohydrolase) (BUP-1).

MLL3_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.002373 (rank : 63)
Query Neighborhood Hits	45	Target Neighborhood Hits	1644	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SIRT5_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.013154 (rank : 57)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

FA62A_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.074697 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.083736 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.070069 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	437	Shared Neighborhood Hits	6
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.059566 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.059616 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS3_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.053147 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.052400 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.084877 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.084879 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYTL1_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.063501 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL1_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.059125 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	314	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL2_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.056642 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	248	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.055376 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	253	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL3_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.074161 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.057450 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.057107 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL5_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.061962 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.061331 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

Hits sorted by NC score

PK3CA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.999669 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CD_HUMAN
NC score	0.981510 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	40	Shared Neighborhood Hits	29
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
NC score	0.981148 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_HUMAN
NC score	0.979301 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
NC score	0.979181 (rank : 6)	θ value	0 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CG_HUMAN
NC score	0.966483 (rank : 7)	θ value	1.32836e-152 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.966066 (rank : 8)	θ value	1.46868e-151 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

P3C2G_HUMAN
NC score	0.908151 (rank : 9)	θ value	2.64101e-84 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
NC score	0.907193 (rank : 10)	θ value	1.76739e-88 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3C3_HUMAN
NC score	0.858057 (rank : 11)	θ value	3.99248e-40 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.856708 (rank : 12)	θ value	1.16164e-39 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	29
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

P3C2A_MOUSE
NC score	0.835068 (rank : 13)	θ value	3.78717e-107 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.832490 (rank : 14)	θ value	2.54029e-103 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PI4KA_HUMAN
NC score	0.830097 (rank : 15)	θ value	1.08726e-37 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2B_HUMAN
NC score	0.811498 (rank : 16)	θ value	1.43912e-106 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PI4KB_MOUSE
NC score	0.778891 (rank : 17)	θ value	2.77775e-25 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KB_HUMAN
NC score	0.776610 (rank : 18)	θ value	2.77775e-25 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	79	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

FRAP_MOUSE
NC score	0.399219 (rank : 19)	θ value	1.53129e-07 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.397926 (rank : 20)	θ value	1.53129e-07 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

PRKDC_MOUSE
NC score	0.367855 (rank : 21)	θ value	0.000158464 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.361526 (rank : 22)	θ value	0.00020696 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

ATM_HUMAN
NC score	0.325151 (rank : 23)	θ value	0.000158464 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATR_HUMAN
NC score	0.321949 (rank : 24)	θ value	0.00175202 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.320491 (rank : 25)	θ value	0.00175202 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_MOUSE
NC score	0.314936 (rank : 26)	θ value	0.000461057 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_MOUSE
NC score	0.267877 (rank : 27)	θ value	0.00869519 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	212	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.265673 (rank : 28)	θ value	0.00869519 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

RIMS4_MOUSE
NC score	0.084879 (rank : 29)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.084877 (rank : 30)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

FA62A_MOUSE
NC score	0.083736 (rank : 31)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.074697 (rank : 32)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL3_MOUSE
NC score	0.074161 (rank : 33)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

RIMS1_HUMAN
NC score	0.070069 (rank : 34)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	437	Shared Neighborhood Hits	6
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SYTL1_HUMAN
NC score	0.063501 (rank : 35)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	45	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL5_HUMAN
NC score	0.061962 (rank : 36)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	45	Target Neighborhood Hits	237	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.061331 (rank : 37)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	45	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

RIMS2_MOUSE
NC score	0.059616 (rank : 38)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	45	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.059566 (rank : 39)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYTL1_MOUSE
NC score	0.059125 (rank : 40)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	45	Target Neighborhood Hits	314	Shared Neighborhood Hits	5
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

SYTL4_HUMAN
NC score	0.057450 (rank : 41)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	45	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
NC score	0.057107 (rank : 42)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	45	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL2_HUMAN
NC score	0.056642 (rank : 43)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	45	Target Neighborhood Hits	248	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
NC score	0.055376 (rank : 44)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	45	Target Neighborhood Hits	253	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

RIMS3_HUMAN
NC score	0.053147 (rank : 45)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	45	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
NC score	0.052400 (rank : 46)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

LARP4_HUMAN
NC score	0.029655 (rank : 47)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q71RC2, Q5CZ97, Q96NF9	Gene names	LARP4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

WASF3_HUMAN
NC score	0.028104 (rank : 48)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	204	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

WASF3_MOUSE
NC score	0.027798 (rank : 49)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	188	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

FBX46_MOUSE
NC score	0.025381 (rank : 50)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

FBX46_HUMAN
NC score	0.024370 (rank : 51)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PJ61	Gene names	FBXO46, FBX46, FBXO34L
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

BUP1_HUMAN
NC score	0.024343 (rank : 52)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UBR1, Q9UIR3	Gene names	UPB1, BUP1
Domain Architecture
Description	Beta-ureidopropionase (EC 3.5.1.6) (Beta-alanine synthase) (N- carbamoyl-beta-alanine amidohydrolase) (BUP-1).

AP4B1_MOUSE
NC score	0.023607 (rank : 53)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV76	Gene names	Ap4b1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta-1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

AP4B1_HUMAN
NC score	0.023046 (rank : 54)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6B7	Gene names	AP4B1
Domain Architecture
Description	AP-4 complex subunit beta-1 (Adapter-related protein complex 4 beta 1 subunit) (Beta subunit of AP-4) (AP-4 adapter complex beta subunit).

WASF1_HUMAN
NC score	0.018882 (rank : 55)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	260	Shared Neighborhood Hits	9
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF1_MOUSE
NC score	0.018750 (rank : 56)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	261	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

SIRT5_MOUSE
NC score	0.013154 (rank : 57)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

AP2B1_MOUSE
NC score	0.012529 (rank : 58)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBG3, Q80XJ4	Gene names	Ap2b1, Clapb1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

AP2B1_HUMAN
NC score	0.012527 (rank : 59)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P63010, P21851, Q96J19	Gene names	AP2B1, CLAPB1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta-1 subunit) (Beta-adaptin) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) (Clathrin assembly protein complex 2 beta large chain) (AP105B).

VATB1_HUMAN
NC score	0.008563 (rank : 60)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P15313	Gene names	ATP6V1B1, ATP6B1, VATB, VPP3
Domain Architecture
Description	Vacuolar ATP synthase subunit B, kidney isoform (EC 3.6.3.14) (V- ATPase B1 subunit) (Vacuolar proton pump B isoform 1) (Endomembrane proton pump 58 kDa subunit).

NALP5_MOUSE
NC score	0.004774 (rank : 61)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	560	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

MLL3_MOUSE
NC score	0.004030 (rank : 62)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	1399	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MLL3_HUMAN
NC score	0.002373 (rank : 63)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	1644	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).