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Network neighborhood for query Sequence : PRKDC_MOUSE

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PRKDC_MOUSE
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PRKDC_HUMAN
θ value	0 (rank : 1)	NC score	0.991668 (rank : 2)
Query Neighborhood Hits	92	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PRKDC_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

FRAP_MOUSE
θ value	3.99248e-40 (rank : 3)	NC score	0.701658 (rank : 3)
Query Neighborhood Hits	92	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
θ value	5.21438e-40 (rank : 4)	NC score	0.701475 (rank : 4)
Query Neighborhood Hits	92	Target Neighborhood Hits	83	Shared Neighborhood Hits	31
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_HUMAN
θ value	1.57e-36 (rank : 5)	NC score	0.696522 (rank : 5)
Query Neighborhood Hits	92	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	4.27553e-34 (rank : 6)	NC score	0.690161 (rank : 6)
Query Neighborhood Hits	92	Target Neighborhood Hits	63	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
θ value	6.17384e-33 (rank : 7)	NC score	0.666895 (rank : 7)
Query Neighborhood Hits	92	Target Neighborhood Hits	78	Shared Neighborhood Hits	31
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
θ value	3.06405e-32 (rank : 8)	NC score	0.661853 (rank : 8)
Query Neighborhood Hits	92	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_HUMAN
θ value	1.98606e-31 (rank : 9)	NC score	0.626354 (rank : 10)
Query Neighborhood Hits	92	Target Neighborhood Hits	231	Shared Neighborhood Hits	37
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	1.98606e-31 (rank : 10)	NC score	0.630363 (rank : 9)
Query Neighborhood Hits	92	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

TRRAP_HUMAN
θ value	1.47631e-18 (rank : 11)	NC score	0.443930 (rank : 14)
Query Neighborhood Hits	92	Target Neighborhood Hits	117	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
θ value	3.63628e-17 (rank : 12)	NC score	0.448781 (rank : 13)
Query Neighborhood Hits	92	Target Neighborhood Hits	42	Shared Neighborhood Hits	16
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

PK3CG_HUMAN
θ value	3.18553e-13 (rank : 13)	NC score	0.432340 (rank : 15)
Query Neighborhood Hits	92	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	9.26847e-13 (rank : 14)	NC score	0.429758 (rank : 17)
Query Neighborhood Hits	92	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CD_MOUSE
θ value	2.28291e-11 (rank : 15)	NC score	0.430136 (rank : 16)
Query Neighborhood Hits	92	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
θ value	2.98157e-11 (rank : 16)	NC score	0.428892 (rank : 19)
Query Neighborhood Hits	92	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3C3_MOUSE
θ value	5.08577e-11 (rank : 17)	NC score	0.473717 (rank : 11)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CB_MOUSE
θ value	8.67504e-11 (rank : 18)	NC score	0.429505 (rank : 18)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3C3_HUMAN
θ value	1.133e-10 (rank : 19)	NC score	0.472772 (rank : 12)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3CB_HUMAN
θ value	3.29651e-10 (rank : 20)	NC score	0.427825 (rank : 20)
Query Neighborhood Hits	92	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PI4KB_HUMAN
θ value	1.43324e-05 (rank : 21)	NC score	0.394248 (rank : 21)
Query Neighborhood Hits	92	Target Neighborhood Hits	79	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	1.43324e-05 (rank : 22)	NC score	0.392409 (rank : 22)
Query Neighborhood Hits	92	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

P3C2B_HUMAN
θ value	0.000121331 (rank : 23)	NC score	0.294297 (rank : 30)
Query Neighborhood Hits	92	Target Neighborhood Hits	148	Shared Neighborhood Hits	30
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2G_HUMAN
θ value	0.000158464 (rank : 24)	NC score	0.344490 (rank : 26)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CA_HUMAN
θ value	0.000158464 (rank : 25)	NC score	0.367855 (rank : 23)
Query Neighborhood Hits	92	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	0.000158464 (rank : 26)	NC score	0.367673 (rank : 24)
Query Neighborhood Hits	92	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_MOUSE
θ value	0.00035302 (rank : 27)	NC score	0.349066 (rank : 25)
Query Neighborhood Hits	92	Target Neighborhood Hits	113	Shared Neighborhood Hits	29
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_MOUSE
θ value	0.00134147 (rank : 28)	NC score	0.308168 (rank : 28)
Query Neighborhood Hits	92	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
θ value	0.00298849 (rank : 29)	NC score	0.304654 (rank : 29)
Query Neighborhood Hits	92	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

SIA8A_MOUSE
θ value	0.0113563 (rank : 30)	NC score	0.041627 (rank : 36)
Query Neighborhood Hits	92	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q64687	Gene names	St8sia1, Siat8, Siat8a
Domain Architecture
Description	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Alpha-2,8- sialyltransferase 8A) (ST8Sia I).

K0423_MOUSE
θ value	0.0563607 (rank : 31)	NC score	0.055328 (rank : 34)
Query Neighborhood Hits	92	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

KMHN1_HUMAN
θ value	0.0961366 (rank : 32)	NC score	0.027265 (rank : 38)
Query Neighborhood Hits	92	Target Neighborhood Hits	950	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

CETP_HUMAN
θ value	0.125558 (rank : 33)	NC score	0.069313 (rank : 31)
Query Neighborhood Hits	92	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P11597, Q13987, Q13988	Gene names	CETP
Domain Architecture
Description	Cholesteryl ester transfer protein precursor (Lipid transfer protein I).

CCD46_HUMAN
θ value	0.21417 (rank : 34)	NC score	0.019243 (rank : 42)
Query Neighborhood Hits	92	Target Neighborhood Hits	1430	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

PI4KA_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.319553 (rank : 27)
Query Neighborhood Hits	92	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

SMC4_HUMAN
θ value	1.06291 (rank : 36)	NC score	0.023115 (rank : 39)
Query Neighborhood Hits	92	Target Neighborhood Hits	937	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

XPO4_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.056197 (rank : 33)
Query Neighborhood Hits	92	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C0E2, Q5VUZ5, Q9H934	Gene names	XPO4, KIAA1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

XPO4_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.056242 (rank : 32)
Query Neighborhood Hits	92	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESJ0, Q6ZPJ4	Gene names	Xpo4, Kiaa1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

SIA8A_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.027833 (rank : 37)
Query Neighborhood Hits	92	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q92185, Q93064	Gene names	ST8SIA1, SIAT8, SIAT8A
Domain Architecture
Description	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Alpha-2,8- sialyltransferase 8A) (ST8Sia I).

SYNE2_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.019075 (rank : 43)
Query Neighborhood Hits	92	Target Neighborhood Hits	1323	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

CENPI_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.044465 (rank : 35)
Query Neighborhood Hits	92	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q92674, Q5JWZ9, Q96ED0	Gene names	CENPI, FSHPRH1, ICEN19, LRPR1
Domain Architecture	No domain graphic available
Description	Centromere protein I (CENP-I) (Interphase centromere complex protein 19) (Follicle-stimulating hormone primary response protein) (FSH primary response protein 1) (Leucine-rich primary response protein 1).

DHX36_HUMAN
θ value	1.81305 (rank : 42)	NC score	0.009462 (rank : 76)
Query Neighborhood Hits	92	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2U1, Q70JU3, Q8IYE5, Q9P240	Gene names	DHX36, DDX36, KIAA1488, MLEL1, RHAU
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

GCC2_MOUSE
θ value	1.81305 (rank : 43)	NC score	0.012995 (rank : 56)
Query Neighborhood Hits	92	Target Neighborhood Hits	1619	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGB1_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.012587 (rank : 59)
Query Neighborhood Hits	92	Target Neighborhood Hits	2297	Shared Neighborhood Hits	32
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ITPR1_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.012160 (rank : 63)
Query Neighborhood Hits	92	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

SPAG5_MOUSE
θ value	1.81305 (rank : 46)	NC score	0.019839 (rank : 41)
Query Neighborhood Hits	92	Target Neighborhood Hits	612	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

CE290_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.015252 (rank : 48)
Query Neighborhood Hits	92	Target Neighborhood Hits	1553	Shared Neighborhood Hits	26
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

HMMR_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.014321 (rank : 52)
Query Neighborhood Hits	92	Target Neighborhood Hits	1082	Shared Neighborhood Hits	24
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

K0776_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.020805 (rank : 40)
Query Neighborhood Hits	92	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCJ3, Q3V145, Q6ZQ50, Q8BT70, Q8C484, Q9D8I8	Gene names	Kiaa0776
Domain Architecture	No domain graphic available
Description	Protein KIAA0776.

MYH6_HUMAN
θ value	2.36792 (rank : 50)	NC score	0.012475 (rank : 60)
Query Neighborhood Hits	92	Target Neighborhood Hits	1426	Shared Neighborhood Hits	27
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

SPA12_HUMAN
θ value	2.36792 (rank : 51)	NC score	0.005773 (rank : 81)
Query Neighborhood Hits	92	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IW75	Gene names	SERPINA12
Domain Architecture	No domain graphic available
Description	Serpin A12 precursor (Visceral adipose-specific serpin) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (OL-64).

BMX_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.001140 (rank : 86)
Query Neighborhood Hits	92	Target Neighborhood Hits	942	Shared Neighborhood Hits	8
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BTK_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.000650 (rank : 88)
Query Neighborhood Hits	92	Target Neighborhood Hits	1026	Shared Neighborhood Hits	6
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FMNL_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.011040 (rank : 68)
Query Neighborhood Hits	92	Target Neighborhood Hits	529	Shared Neighborhood Hits	11
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

MYO1B_MOUSE
θ value	3.0926 (rank : 55)	NC score	0.010234 (rank : 72)
Query Neighborhood Hits	92	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

PCLO_MOUSE
θ value	3.0926 (rank : 56)	NC score	0.013045 (rank : 55)
Query Neighborhood Hits	92	Target Neighborhood Hits	2275	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TPM2_HUMAN
θ value	3.0926 (rank : 57)	NC score	0.016644 (rank : 46)
Query Neighborhood Hits	92	Target Neighborhood Hits	677	Shared Neighborhood Hits	20
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM2_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.017133 (rank : 45)
Query Neighborhood Hits	92	Target Neighborhood Hits	676	Shared Neighborhood Hits	21
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

ZN567_HUMAN
θ value	3.0926 (rank : 59)	NC score	-0.002469 (rank : 92)
Query Neighborhood Hits	92	Target Neighborhood Hits	769	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N184, Q6N044	Gene names	ZNF567
Domain Architecture	No domain graphic available
Description	Zinc finger protein 567.

BTK_MOUSE
θ value	4.03905 (rank : 60)	NC score	0.000486 (rank : 89)
Query Neighborhood Hits	92	Target Neighborhood Hits	1017	Shared Neighborhood Hits	6
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CAB45_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.013516 (rank : 53)
Query Neighborhood Hits	92	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRK5, Q8NBQ3, Q9NZP7	Gene names	SDF4, CAB45
Domain Architecture
Description	45 kDa calcium-binding protein precursor (Cab45) (Stromal cell-derived factor 4) (SDF-4).

CALX_HUMAN
θ value	4.03905 (rank : 62)	NC score	0.010679 (rank : 69)
Query Neighborhood Hits	92	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	P27824	Gene names	CANX
Domain Architecture
Description	Calnexin precursor (Major histocompatibility complex class I antigen- binding protein p88) (p90) (IP90).

CD2L7_HUMAN
θ value	4.03905 (rank : 63)	NC score	-0.000229 (rank : 90)
Query Neighborhood Hits	92	Target Neighborhood Hits	1275	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

KIF2B_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.005110 (rank : 84)
Query Neighborhood Hits	92	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N4N8, Q96MA2, Q9BXG6	Gene names	KIF2B
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF2B.

RPGF2_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.012213 (rank : 61)
Query Neighborhood Hits	92	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SORC3_HUMAN
θ value	4.03905 (rank : 66)	NC score	0.011946 (rank : 64)
Query Neighborhood Hits	92	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

GDF9_HUMAN
θ value	5.27518 (rank : 67)	NC score	0.007837 (rank : 78)
Query Neighborhood Hits	92	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	O60383	Gene names	GDF9
Domain Architecture
Description	Growth/differentiation factor 9 precursor (GDF-9).

M6PBP_MOUSE
θ value	5.27518 (rank : 68)	NC score	0.012162 (rank : 62)
Query Neighborhood Hits	92	Target Neighborhood Hits	91	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBG5, Q3TK05, Q8BKV9, Q9CZK1	Gene names	M6prbp1, Tip47
Domain Architecture	No domain graphic available
Description	Mannose-6-phosphate receptor-binding protein 1 (Cargo selection protein TIP47).

PAI2_MOUSE
θ value	5.27518 (rank : 69)	NC score	0.004333 (rank : 85)
Query Neighborhood Hits	92	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	P12388, O35687, Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6	Gene names	Serpinb2, Pai2, Planh2
Domain Architecture
Description	Plasminogen activator inhibitor 2, macrophage (PAI-2).

PON3_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.010013 (rank : 74)
Query Neighborhood Hits	92	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q62087, Q8C2I7	Gene names	Pon3
Domain Architecture
Description	Serum paraoxonase/lactonase 3 (EC 3.1.1.-).

SLC2B_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.015648 (rank : 47)
Query Neighborhood Hits	92	Target Neighborhood Hits	214	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

SORC3_MOUSE
θ value	5.27518 (rank : 72)	NC score	0.011322 (rank : 67)
Query Neighborhood Hits	92	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

ST18_MOUSE
θ value	5.27518 (rank : 73)	NC score	0.013213 (rank : 54)
Query Neighborhood Hits	92	Target Neighborhood Hits	248	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TY4, Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q811B4, Q8K098	Gene names	St18, Kiaa0535
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18.

XPOT_HUMAN
θ value	5.27518 (rank : 74)	NC score	0.018125 (rank : 44)
Query Neighborhood Hits	92	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O43592, O43784, Q8WUG2, Q9BVS7	Gene names	XPOT
Domain Architecture
Description	Exportin-T (tRNA exportin) (Exportin(tRNA)).

CP135_MOUSE
θ value	6.88961 (rank : 75)	NC score	0.011699 (rank : 66)
Query Neighborhood Hits	92	Target Neighborhood Hits	1278	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

K1H1_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.005277 (rank : 83)
Query Neighborhood Hits	92	Target Neighborhood Hits	433	Shared Neighborhood Hits	14
SwissProt Accessions	Q15323	Gene names	KRTHA1, HHA1, HKA1
Domain Architecture
Description	Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1).

K1HA_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.005297 (rank : 82)
Query Neighborhood Hits	92	Target Neighborhood Hits	502	Shared Neighborhood Hits	17
SwissProt Accessions	O76009	Gene names	KRTHA3A, HHA3-I, HKA3A
Domain Architecture
Description	Keratin, type I cuticular Ha3-I (Hair keratin, type I Ha3-I).

NOTC2_MOUSE
θ value	6.88961 (rank : 78)	NC score	-0.001088 (rank : 91)
Query Neighborhood Hits	92	Target Neighborhood Hits	1069	Shared Neighborhood Hits	4
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

RPGF6_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.009949 (rank : 75)
Query Neighborhood Hits	92	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

S35A3_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.012837 (rank : 58)
Query Neighborhood Hits	92	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2D2, Q68CR2	Gene names	SLC35A3
Domain Architecture
Description	UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3).

S35A3_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.012892 (rank : 57)
Query Neighborhood Hits	92	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1T4, Q8BRW7	Gene names	Slc35a3
Domain Architecture	No domain graphic available
Description	UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3).

SMC4_MOUSE
θ value	6.88961 (rank : 82)	NC score	0.015207 (rank : 49)
Query Neighborhood Hits	92	Target Neighborhood Hits	830	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SVIL_HUMAN
θ value	6.88961 (rank : 83)	NC score	0.007613 (rank : 79)
Query Neighborhood Hits	92	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TPM1_HUMAN
θ value	6.88961 (rank : 84)	NC score	0.015207 (rank : 50)
Query Neighborhood Hits	92	Target Neighborhood Hits	716	Shared Neighborhood Hits	22
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	6.88961 (rank : 85)	NC score	0.015111 (rank : 51)
Query Neighborhood Hits	92	Target Neighborhood Hits	729	Shared Neighborhood Hits	22
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

ANPRA_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.001126 (rank : 87)
Query Neighborhood Hits	92	Target Neighborhood Hits	612	Shared Neighborhood Hits	6
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

COG2_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.010209 (rank : 73)
Query Neighborhood Hits	92	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q921L5, Q9CSQ1	Gene names	Cog2, Ldlc
Domain Architecture
Description	Conserved oligomeric Golgi complex component 2 (Low density lipoprotein receptor defect C-complementing protein).

HIP1_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.008504 (rank : 77)
Query Neighborhood Hits	92	Target Neighborhood Hits	1016	Shared Neighborhood Hits	21
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

MAMC2_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.010528 (rank : 70)
Query Neighborhood Hits	92	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAMC2_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.010485 (rank : 71)
Query Neighborhood Hits	92	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

ST18_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.011859 (rank : 65)
Query Neighborhood Hits	92	Target Neighborhood Hits	252	Shared Neighborhood Hits	14
SwissProt Accessions	O60284	Gene names	ST18, KIAA0535, ZNF387
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18 (Zinc finger protein 387).

TRI44_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.006320 (rank : 80)
Query Neighborhood Hits	92	Target Neighborhood Hits	393	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

Hits sorted by NC score

PRKDC_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.991668 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	92	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

FRAP_MOUSE
NC score	0.701658 (rank : 3)	θ value	3.99248e-40 (rank : 3)
Query Neighborhood Hits	92	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.701475 (rank : 4)	θ value	5.21438e-40 (rank : 4)
Query Neighborhood Hits	92	Target Neighborhood Hits	83	Shared Neighborhood Hits	31
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_HUMAN
NC score	0.696522 (rank : 5)	θ value	1.57e-36 (rank : 5)
Query Neighborhood Hits	92	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.690161 (rank : 6)	θ value	4.27553e-34 (rank : 6)
Query Neighborhood Hits	92	Target Neighborhood Hits	63	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
NC score	0.666895 (rank : 7)	θ value	6.17384e-33 (rank : 7)
Query Neighborhood Hits	92	Target Neighborhood Hits	78	Shared Neighborhood Hits	31
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
NC score	0.661853 (rank : 8)	θ value	3.06405e-32 (rank : 8)
Query Neighborhood Hits	92	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_MOUSE
NC score	0.630363 (rank : 9)	θ value	1.98606e-31 (rank : 10)
Query Neighborhood Hits	92	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.626354 (rank : 10)	θ value	1.98606e-31 (rank : 9)
Query Neighborhood Hits	92	Target Neighborhood Hits	231	Shared Neighborhood Hits	37
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

PK3C3_MOUSE
NC score	0.473717 (rank : 11)	θ value	5.08577e-11 (rank : 17)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.472772 (rank : 12)	θ value	1.133e-10 (rank : 19)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

TRRAP_MOUSE
NC score	0.448781 (rank : 13)	θ value	3.63628e-17 (rank : 12)
Query Neighborhood Hits	92	Target Neighborhood Hits	42	Shared Neighborhood Hits	16
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

TRRAP_HUMAN
NC score	0.443930 (rank : 14)	θ value	1.47631e-18 (rank : 11)
Query Neighborhood Hits	92	Target Neighborhood Hits	117	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3CG_HUMAN
NC score	0.432340 (rank : 15)	θ value	3.18553e-13 (rank : 13)
Query Neighborhood Hits	92	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CD_MOUSE
NC score	0.430136 (rank : 16)	θ value	2.28291e-11 (rank : 15)
Query Neighborhood Hits	92	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_MOUSE
NC score	0.429758 (rank : 17)	θ value	9.26847e-13 (rank : 14)
Query Neighborhood Hits	92	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CB_MOUSE
NC score	0.429505 (rank : 18)	θ value	8.67504e-11 (rank : 18)
Query Neighborhood Hits	92	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
NC score	0.428892 (rank : 19)	θ value	2.98157e-11 (rank : 16)
Query Neighborhood Hits	92	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_HUMAN
NC score	0.427825 (rank : 20)	θ value	3.29651e-10 (rank : 20)
Query Neighborhood Hits	92	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PI4KB_HUMAN
NC score	0.394248 (rank : 21)	θ value	1.43324e-05 (rank : 21)
Query Neighborhood Hits	92	Target Neighborhood Hits	79	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
NC score	0.392409 (rank : 22)	θ value	1.43324e-05 (rank : 22)
Query Neighborhood Hits	92	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CA_HUMAN
NC score	0.367855 (rank : 23)	θ value	0.000158464 (rank : 25)
Query Neighborhood Hits	92	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.367673 (rank : 24)	θ value	0.000158464 (rank : 26)
Query Neighborhood Hits	92	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_MOUSE
NC score	0.349066 (rank : 25)	θ value	0.00035302 (rank : 27)
Query Neighborhood Hits	92	Target Neighborhood Hits	113	Shared Neighborhood Hits	29
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
NC score	0.344490 (rank : 26)	θ value	0.000158464 (rank : 24)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
NC score	0.319553 (rank : 27)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	92	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2A_MOUSE
NC score	0.308168 (rank : 28)	θ value	0.00134147 (rank : 28)
Query Neighborhood Hits	92	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.304654 (rank : 29)	θ value	0.00298849 (rank : 29)
Query Neighborhood Hits	92	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.294297 (rank : 30)	θ value	0.000121331 (rank : 23)
Query Neighborhood Hits	92	Target Neighborhood Hits	148	Shared Neighborhood Hits	30
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

CETP_HUMAN
NC score	0.069313 (rank : 31)	θ value	0.125558 (rank : 33)
Query Neighborhood Hits	92	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P11597, Q13987, Q13988	Gene names	CETP
Domain Architecture
Description	Cholesteryl ester transfer protein precursor (Lipid transfer protein I).

XPO4_MOUSE
NC score	0.056242 (rank : 32)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	92	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESJ0, Q6ZPJ4	Gene names	Xpo4, Kiaa1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

XPO4_HUMAN
NC score	0.056197 (rank : 33)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	92	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C0E2, Q5VUZ5, Q9H934	Gene names	XPO4, KIAA1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

K0423_MOUSE
NC score	0.055328 (rank : 34)	θ value	0.0563607 (rank : 31)
Query Neighborhood Hits	92	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

CENPI_HUMAN
NC score	0.044465 (rank : 35)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	92	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q92674, Q5JWZ9, Q96ED0	Gene names	CENPI, FSHPRH1, ICEN19, LRPR1
Domain Architecture	No domain graphic available
Description	Centromere protein I (CENP-I) (Interphase centromere complex protein 19) (Follicle-stimulating hormone primary response protein) (FSH primary response protein 1) (Leucine-rich primary response protein 1).

SIA8A_MOUSE
NC score	0.041627 (rank : 36)	θ value	0.0113563 (rank : 30)
Query Neighborhood Hits	92	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q64687	Gene names	St8sia1, Siat8, Siat8a
Domain Architecture
Description	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Alpha-2,8- sialyltransferase 8A) (ST8Sia I).

SIA8A_HUMAN
NC score	0.027833 (rank : 37)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	92	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q92185, Q93064	Gene names	ST8SIA1, SIAT8, SIAT8A
Domain Architecture
Description	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Alpha-2,8- sialyltransferase 8A) (ST8Sia I).

KMHN1_HUMAN
NC score	0.027265 (rank : 38)	θ value	0.0961366 (rank : 32)
Query Neighborhood Hits	92	Target Neighborhood Hits	950	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

SMC4_HUMAN
NC score	0.023115 (rank : 39)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	92	Target Neighborhood Hits	937	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

K0776_MOUSE
NC score	0.020805 (rank : 40)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	92	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCJ3, Q3V145, Q6ZQ50, Q8BT70, Q8C484, Q9D8I8	Gene names	Kiaa0776
Domain Architecture	No domain graphic available
Description	Protein KIAA0776.

SPAG5_MOUSE
NC score	0.019839 (rank : 41)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	92	Target Neighborhood Hits	612	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

CCD46_HUMAN
NC score	0.019243 (rank : 42)	θ value	0.21417 (rank : 34)
Query Neighborhood Hits	92	Target Neighborhood Hits	1430	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

SYNE2_HUMAN
NC score	0.019075 (rank : 43)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	92	Target Neighborhood Hits	1323	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

XPOT_HUMAN
NC score	0.018125 (rank : 44)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	92	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O43592, O43784, Q8WUG2, Q9BVS7	Gene names	XPOT
Domain Architecture
Description	Exportin-T (tRNA exportin) (Exportin(tRNA)).

TPM2_MOUSE
NC score	0.017133 (rank : 45)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	92	Target Neighborhood Hits	676	Shared Neighborhood Hits	21
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM2_HUMAN
NC score	0.016644 (rank : 46)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	92	Target Neighborhood Hits	677	Shared Neighborhood Hits	20
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

SLC2B_HUMAN
NC score	0.015648 (rank : 47)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	92	Target Neighborhood Hits	214	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEV8, Q9Y4D6	Gene names	EXPH5, KIAA0624, SLAC2B
Domain Architecture	No domain graphic available
Description	Slp homolog lacking C2 domains b (Exophilin-5).

CE290_HUMAN
NC score	0.015252 (rank : 48)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	92	Target Neighborhood Hits	1553	Shared Neighborhood Hits	26
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

SMC4_MOUSE
NC score	0.015207 (rank : 49)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	92	Target Neighborhood Hits	830	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

TPM1_HUMAN
NC score	0.015207 (rank : 50)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	92	Target Neighborhood Hits	716	Shared Neighborhood Hits	22
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
NC score	0.015111 (rank : 51)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	92	Target Neighborhood Hits	729	Shared Neighborhood Hits	22
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

HMMR_HUMAN
NC score	0.014321 (rank : 52)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	92	Target Neighborhood Hits	1082	Shared Neighborhood Hits	24
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

CAB45_HUMAN
NC score	0.013516 (rank : 53)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	92	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRK5, Q8NBQ3, Q9NZP7	Gene names	SDF4, CAB45
Domain Architecture
Description	45 kDa calcium-binding protein precursor (Cab45) (Stromal cell-derived factor 4) (SDF-4).

ST18_MOUSE
NC score	0.013213 (rank : 54)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	92	Target Neighborhood Hits	248	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TY4, Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q811B4, Q8K098	Gene names	St18, Kiaa0535
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18.

PCLO_MOUSE
NC score	0.013045 (rank : 55)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	92	Target Neighborhood Hits	2275	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

GCC2_MOUSE
NC score	0.012995 (rank : 56)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	92	Target Neighborhood Hits	1619	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

S35A3_MOUSE
NC score	0.012892 (rank : 57)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	92	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1T4, Q8BRW7	Gene names	Slc35a3
Domain Architecture	No domain graphic available
Description	UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3).

S35A3_HUMAN
NC score	0.012837 (rank : 58)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	92	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2D2, Q68CR2	Gene names	SLC35A3
Domain Architecture
Description	UDP-N-acetylglucosamine transporter (Golgi UDP-GlcNAc transporter) (Solute carrier family 35 member A3).

GOGB1_HUMAN
NC score	0.012587 (rank : 59)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	92	Target Neighborhood Hits	2297	Shared Neighborhood Hits	32
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

MYH6_HUMAN
NC score	0.012475 (rank : 60)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	92	Target Neighborhood Hits	1426	Shared Neighborhood Hits	27
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

RPGF2_HUMAN
NC score	0.012213 (rank : 61)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	92	Target Neighborhood Hits	242	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

M6PBP_MOUSE
NC score	0.012162 (rank : 62)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	92	Target Neighborhood Hits	91	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBG5, Q3TK05, Q8BKV9, Q9CZK1	Gene names	M6prbp1, Tip47
Domain Architecture	No domain graphic available
Description	Mannose-6-phosphate receptor-binding protein 1 (Cargo selection protein TIP47).

ITPR1_HUMAN
NC score	0.012160 (rank : 63)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	92	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

SORC3_HUMAN
NC score	0.011946 (rank : 64)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	92	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

ST18_HUMAN
NC score	0.011859 (rank : 65)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	92	Target Neighborhood Hits	252	Shared Neighborhood Hits	14
SwissProt Accessions	O60284	Gene names	ST18, KIAA0535, ZNF387
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18 (Zinc finger protein 387).

CP135_MOUSE
NC score	0.011699 (rank : 66)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	92	Target Neighborhood Hits	1278	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

SORC3_MOUSE
NC score	0.011322 (rank : 67)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	92	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

FMNL_HUMAN
NC score	0.011040 (rank : 68)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	92	Target Neighborhood Hits	529	Shared Neighborhood Hits	11
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

CALX_HUMAN
NC score	0.010679 (rank : 69)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	92	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	P27824	Gene names	CANX
Domain Architecture
Description	Calnexin precursor (Major histocompatibility complex class I antigen- binding protein p88) (p90) (IP90).

MAMC2_HUMAN
NC score	0.010528 (rank : 70)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	92	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAMC2_MOUSE
NC score	0.010485 (rank : 71)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	92	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MYO1B_MOUSE
NC score	0.010234 (rank : 72)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	92	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

COG2_MOUSE
NC score	0.010209 (rank : 73)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	92	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q921L5, Q9CSQ1	Gene names	Cog2, Ldlc
Domain Architecture
Description	Conserved oligomeric Golgi complex component 2 (Low density lipoprotein receptor defect C-complementing protein).

PON3_MOUSE
NC score	0.010013 (rank : 74)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	92	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q62087, Q8C2I7	Gene names	Pon3
Domain Architecture
Description	Serum paraoxonase/lactonase 3 (EC 3.1.1.-).

RPGF6_HUMAN
NC score	0.009949 (rank : 75)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	92	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

DHX36_HUMAN
NC score	0.009462 (rank : 76)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	92	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2U1, Q70JU3, Q8IYE5, Q9P240	Gene names	DHX36, DDX36, KIAA1488, MLEL1, RHAU
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

HIP1_HUMAN
NC score	0.008504 (rank : 77)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	92	Target Neighborhood Hits	1016	Shared Neighborhood Hits	21
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

GDF9_HUMAN
NC score	0.007837 (rank : 78)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	92	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	O60383	Gene names	GDF9
Domain Architecture
Description	Growth/differentiation factor 9 precursor (GDF-9).

SVIL_HUMAN
NC score	0.007613 (rank : 79)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	92	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TRI44_HUMAN
NC score	0.006320 (rank : 80)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	92	Target Neighborhood Hits	393	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

SPA12_HUMAN
NC score	0.005773 (rank : 81)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	92	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IW75	Gene names	SERPINA12
Domain Architecture	No domain graphic available
Description	Serpin A12 precursor (Visceral adipose-specific serpin) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (OL-64).

K1HA_HUMAN
NC score	0.005297 (rank : 82)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	92	Target Neighborhood Hits	502	Shared Neighborhood Hits	17
SwissProt Accessions	O76009	Gene names	KRTHA3A, HHA3-I, HKA3A
Domain Architecture
Description	Keratin, type I cuticular Ha3-I (Hair keratin, type I Ha3-I).

K1H1_HUMAN
NC score	0.005277 (rank : 83)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	92	Target Neighborhood Hits	433	Shared Neighborhood Hits	14
SwissProt Accessions	Q15323	Gene names	KRTHA1, HHA1, HKA1
Domain Architecture
Description	Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1).

KIF2B_HUMAN
NC score	0.005110 (rank : 84)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	92	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N4N8, Q96MA2, Q9BXG6	Gene names	KIF2B
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF2B.

PAI2_MOUSE
NC score	0.004333 (rank : 85)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	92	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	P12388, O35687, Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6	Gene names	Serpinb2, Pai2, Planh2
Domain Architecture
Description	Plasminogen activator inhibitor 2, macrophage (PAI-2).

BMX_HUMAN
NC score	0.001140 (rank : 86)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	92	Target Neighborhood Hits	942	Shared Neighborhood Hits	8
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ANPRA_HUMAN
NC score	0.001126 (rank : 87)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	92	Target Neighborhood Hits	612	Shared Neighborhood Hits	6
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

BTK_HUMAN
NC score	0.000650 (rank : 88)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	92	Target Neighborhood Hits	1026	Shared Neighborhood Hits	6
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.000486 (rank : 89)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	92	Target Neighborhood Hits	1017	Shared Neighborhood Hits	6
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CD2L7_HUMAN
NC score	-0.000229 (rank : 90)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	92	Target Neighborhood Hits	1275	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

NOTC2_MOUSE
NC score	-0.001088 (rank : 91)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	92	Target Neighborhood Hits	1069	Shared Neighborhood Hits	4
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

ZN567_HUMAN
NC score	-0.002469 (rank : 92)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	92	Target Neighborhood Hits	769	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N184, Q6N044	Gene names	ZNF567
Domain Architecture	No domain graphic available
Description	Zinc finger protein 567.