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Network neighborhood for query Sequence : PRKDC_HUMAN

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PRKDC_HUMAN
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PRKDC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PRKDC_MOUSE
θ value	0 (rank : 2)	NC score	0.991668 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	38
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ATR_HUMAN
θ value	9.83387e-39 (rank : 3)	NC score	0.693285 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	1.20211e-36 (rank : 4)	NC score	0.687440 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

FRAP_HUMAN
θ value	5.96599e-36 (rank : 5)	NC score	0.688724 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	83	Shared Neighborhood Hits	31
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	2.26708e-35 (rank : 6)	NC score	0.688829 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATM_MOUSE
θ value	2.59387e-31 (rank : 7)	NC score	0.655754 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATM_HUMAN
θ value	4.42448e-31 (rank : 8)	NC score	0.660001 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

SMG1_HUMAN
θ value	1.33217e-27 (rank : 9)	NC score	0.613221 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	1.73987e-27 (rank : 10)	NC score	0.617804 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	212	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

TRRAP_HUMAN
θ value	5.43371e-13 (rank : 11)	NC score	0.418417 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3CD_MOUSE
θ value	7.09661e-13 (rank : 12)	NC score	0.425972 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
θ value	9.26847e-13 (rank : 13)	NC score	0.424664 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

TRRAP_MOUSE
θ value	1.58096e-12 (rank : 14)	NC score	0.423641 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

PK3CG_HUMAN
θ value	2.0648e-12 (rank : 15)	NC score	0.425282 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	2.69671e-12 (rank : 16)	NC score	0.422847 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CB_MOUSE
θ value	1.133e-10 (rank : 17)	NC score	0.424391 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
θ value	2.52405e-10 (rank : 18)	NC score	0.422747 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3C3_HUMAN
θ value	6.43352e-06 (rank : 19)	NC score	0.448473 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	6.43352e-06 (rank : 20)	NC score	0.449485 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PI4KB_HUMAN
θ value	2.44474e-05 (rank : 21)	NC score	0.384119 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	2.44474e-05 (rank : 22)	NC score	0.382334 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CA_HUMAN
θ value	0.00020696 (rank : 23)	NC score	0.361526 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	0.00020696 (rank : 24)	NC score	0.361361 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2A_MOUSE
θ value	0.000786445 (rank : 25)	NC score	0.299951 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2G_MOUSE
θ value	0.000786445 (rank : 26)	NC score	0.338660 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2B_HUMAN
θ value	0.00134147 (rank : 27)	NC score	0.285459 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2G_HUMAN
θ value	0.00175202 (rank : 28)	NC score	0.333730 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_HUMAN
θ value	0.00228821 (rank : 29)	NC score	0.296407 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

XPO4_HUMAN
θ value	0.0961366 (rank : 30)	NC score	0.070797 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C0E2, Q5VUZ5, Q9H934	Gene names	XPO4, KIAA1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

XPO4_MOUSE
θ value	0.0961366 (rank : 31)	NC score	0.070886 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESJ0, Q6ZPJ4	Gene names	Xpo4, Kiaa1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

CENPI_HUMAN
θ value	0.365318 (rank : 32)	NC score	0.050882 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q92674, Q5JWZ9, Q96ED0	Gene names	CENPI, FSHPRH1, ICEN19, LRPR1
Domain Architecture	No domain graphic available
Description	Centromere protein I (CENP-I) (Interphase centromere complex protein 19) (Follicle-stimulating hormone primary response protein) (FSH primary response protein 1) (Leucine-rich primary response protein 1).

EVPL_MOUSE
θ value	0.62314 (rank : 33)	NC score	0.015055 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	952	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FZD6_MOUSE
θ value	0.813845 (rank : 34)	NC score	0.011381 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

CX4NB_MOUSE
θ value	1.06291 (rank : 35)	NC score	0.029066 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	O70378	Gene names	Cox4nb, Cox4al, Noc4
Domain Architecture
Description	Neighbor of COX4.

MYO1B_MOUSE
θ value	1.06291 (rank : 36)	NC score	0.009817 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

PI4KA_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.307833 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

SCYL2_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.015531 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	603	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ACSL1_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.013541 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P33121, P41215, Q8N8V7, Q8TA99	Gene names	ACSL1, FACL1, FACL2, LACS, LACS1, LACS2
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase 1) (Long-chain fatty acid CoA ligase 2) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Acyl-CoA synthetase 1) (ACS1) (Palmitoyl-CoA ligase 2).

APBA1_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.014443 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	325	Shared Neighborhood Hits	2
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

CETP_HUMAN
θ value	1.38821 (rank : 41)	NC score	0.061673 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P11597, Q13987, Q13988	Gene names	CETP
Domain Architecture
Description	Cholesteryl ester transfer protein precursor (Lipid transfer protein I).

DMXL2_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.017818 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	374	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

K0423_MOUSE
θ value	1.38821 (rank : 43)	NC score	0.045830 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

E2F3_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.021059 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	O00716, Q15000, Q9BZ44	Gene names	E2F3, KIAA0075
Domain Architecture
Description	Transcription factor E2F3 (E2F-3).

E2F3_MOUSE
θ value	1.81305 (rank : 45)	NC score	0.021131 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

RELN_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.021333 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	P78509, Q86UJ0, Q86UJ8, Q8NDV0, Q9UDQ2	Gene names	RELN
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-).

KMHN1_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.017256 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	950	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

SMC4_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.014501 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	937	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

RHPN1_HUMAN
θ value	3.0926 (rank : 49)	NC score	0.011784 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SCYL2_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.012547 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	632	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

CREM_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.012928 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	P27699, P27698	Gene names	Crem
Domain Architecture
Description	cAMP-responsive element modulator.

KIF3B_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.004364 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	533	Shared Neighborhood Hits	8
SwissProt Accessions	Q61771	Gene names	Kif3b
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B).

DDX54_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.005503 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

MAGB2_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.005236 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	O15479, O75860	Gene names	MAGEB2
Domain Architecture
Description	Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2).

PFTB_MOUSE
θ value	5.27518 (rank : 55)	NC score	0.013096 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2I1	Gene names	Fntb
Domain Architecture	No domain graphic available
Description	Protein farnesyltransferase subunit beta (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) (FTase-beta).

UN93B_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.014107 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCW4, O89077, Q710D2, Q8CIK1, Q8R3D0	Gene names	Unc93b1, Unc93b
Domain Architecture	No domain graphic available
Description	UNC93 homolog B1 (UNC-93B protein).

UNG2_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.022955 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P22674	Gene names	UNG2
Domain Architecture
Description	Uracil-DNA glycosylase 2 (EC 3.2.2.-) (UDG 2).

CENPE_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.003463 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	2060	Shared Neighborhood Hits	23
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CUL3_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.009643 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

CUL3_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.009648 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

DDX54_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.005050 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

EEA1_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.002503 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	1637	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FAF1_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.011079 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	P54731	Gene names	Faf1
Domain Architecture
Description	FAS-associated factor 1 (Protein FAF1).

FBX41_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.012294 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	475	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

FBX41_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.012823 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	430	Shared Neighborhood Hits	8
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

GBF1_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.007673 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	2
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

LIPA1_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.003195 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	1294	Shared Neighborhood Hits	14
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

RBBP8_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.012731 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	476	Shared Neighborhood Hits	12
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

RELN_MOUSE
θ value	6.88961 (rank : 69)	NC score	0.017044 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	Q60841, Q9CUA6	Gene names	Reln, Rl
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-) (Reeler protein).

RENT2_HUMAN
θ value	6.88961 (rank : 70)	NC score	0.010058 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	618	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

RIT1_HUMAN
θ value	6.88961 (rank : 71)	NC score	0.001872 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	265	Shared Neighborhood Hits	3
SwissProt Accessions	Q92963, O00646, O00720	Gene names	RIT1, RIBB, RIT, ROC1
Domain Architecture
Description	GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1).

RIT1_MOUSE
θ value	6.88961 (rank : 72)	NC score	0.001866 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	266	Shared Neighborhood Hits	3
SwissProt Accessions	P70426	Gene names	Rit1, Rit
Domain Architecture
Description	GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1).

SEM6D_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.003219 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SLK_HUMAN
θ value	6.88961 (rank : 74)	NC score	-0.002720 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	1775	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

TRI32_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.008899 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	264	Shared Neighborhood Hits	3
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.008937 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TTC12_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.008002 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H892, Q8N5H9, Q9NWY3	Gene names	TTC12
Domain Architecture
Description	Tetratricopeptide repeat protein 12 (TPR repeat protein 12).

UB2L3_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.007520 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P68036, P51966, P70653, Q9HAV1	Gene names	UBE2L3, UBCE7, UBCH7
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 L3 (EC 6.3.2.19) (Ubiquitin-protein ligase L3) (Ubiquitin carrier protein L3) (UbcH7) (E2-F1) (L-UBC).

UB2L3_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.007520 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P68037, P51966, P70653, Q9HAV1	Gene names	Ube2l3, Ubce7
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 L3 (EC 6.3.2.19) (Ubiquitin-protein ligase L3) (Ubiquitin carrier protein L3) (UbcM4).

CASP8_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.006049 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

CLH2_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.007181 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P53675, Q14017, Q15808, Q15809	Gene names	CLTCL1, CLH22, CLTCL, CLTD
Domain Architecture
Description	Clathrin heavy chain 2 (CLH-22).

CU056_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.011578 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0A9, Q9NSE5	Gene names	C21orf56
Domain Architecture	No domain graphic available
Description	Putative protein C21orf56.

DMXL1_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.012894 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	259	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

ENSA_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.011439 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O43768, Q9NRZ0	Gene names	ENSA
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

LRBA_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.006354 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	196	Shared Neighborhood Hits	6
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

NMNA2_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.008788 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BNJ3	Gene names	Nmnat2, Kiaa0479
Domain Architecture
Description	Nicotinamide mononucleotide adenylyltransferase 2 (EC 2.7.7.1) (NMN adenylyltransferase 2).

PLD1_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.007547 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z280, O35911	Gene names	Pld1
Domain Architecture
Description	Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (mPLD1).

PRPF3_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.014101 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

PRPF3_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.013964 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

TEP1_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.003810 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	344	Shared Neighborhood Hits	4
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

UTP20_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.010056 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O75691, Q9H3H4	Gene names	UTP20, DRIM
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Protein Key-1A6) (Novel nucleolar protein 73) (NNP73).

ZDHC5_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.006397 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C0B5, Q6ZMF0, Q8TAK8, Q9H923, Q9UFI7	Gene names	ZDHHC5, KIAA1748, ZNF375
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375).

ZDHC5_MOUSE
θ value	8.99809 (rank : 93)	NC score	0.006374 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDZ4, Q69ZB5, Q8R2X7	Gene names	Zdhhc5, Kiaa1748
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5).

Hits sorted by NC score

PRKDC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PRKDC_MOUSE
NC score	0.991668 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	38
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ATR_HUMAN
NC score	0.693285 (rank : 3)	θ value	9.83387e-39 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

FRAP_MOUSE
NC score	0.688829 (rank : 4)	θ value	2.26708e-35 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.688724 (rank : 5)	θ value	5.96599e-36 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	83	Shared Neighborhood Hits	31
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_MOUSE
NC score	0.687440 (rank : 6)	θ value	1.20211e-36 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
NC score	0.660001 (rank : 7)	θ value	4.42448e-31 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
NC score	0.655754 (rank : 8)	θ value	2.59387e-31 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_MOUSE
NC score	0.617804 (rank : 9)	θ value	1.73987e-27 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	212	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.613221 (rank : 10)	θ value	1.33217e-27 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

PK3C3_MOUSE
NC score	0.449485 (rank : 11)	θ value	6.43352e-06 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.448473 (rank : 12)	θ value	6.43352e-06 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3CD_MOUSE
NC score	0.425972 (rank : 13)	θ value	7.09661e-13 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_HUMAN
NC score	0.425282 (rank : 14)	θ value	2.0648e-12 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CD_HUMAN
NC score	0.424664 (rank : 15)	θ value	9.26847e-13 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_MOUSE
NC score	0.424391 (rank : 16)	θ value	1.133e-10 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

TRRAP_MOUSE
NC score	0.423641 (rank : 17)	θ value	1.58096e-12 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

PK3CG_MOUSE
NC score	0.422847 (rank : 18)	θ value	2.69671e-12 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CB_HUMAN
NC score	0.422747 (rank : 19)	θ value	2.52405e-10 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

TRRAP_HUMAN
NC score	0.418417 (rank : 20)	θ value	5.43371e-13 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PI4KB_HUMAN
NC score	0.384119 (rank : 21)	θ value	2.44474e-05 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
NC score	0.382334 (rank : 22)	θ value	2.44474e-05 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CA_HUMAN
NC score	0.361526 (rank : 23)	θ value	0.00020696 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.361361 (rank : 24)	θ value	0.00020696 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_MOUSE
NC score	0.338660 (rank : 25)	θ value	0.000786445 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
NC score	0.333730 (rank : 26)	θ value	0.00175202 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
NC score	0.307833 (rank : 27)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2A_MOUSE
NC score	0.299951 (rank : 28)	θ value	0.000786445 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.296407 (rank : 29)	θ value	0.00228821 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.285459 (rank : 30)	θ value	0.00134147 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

XPO4_MOUSE
NC score	0.070886 (rank : 31)	θ value	0.0961366 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESJ0, Q6ZPJ4	Gene names	Xpo4, Kiaa1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

XPO4_HUMAN
NC score	0.070797 (rank : 32)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C0E2, Q5VUZ5, Q9H934	Gene names	XPO4, KIAA1721
Domain Architecture	No domain graphic available
Description	Exportin-4 (Exp4).

CETP_HUMAN
NC score	0.061673 (rank : 33)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P11597, Q13987, Q13988	Gene names	CETP
Domain Architecture
Description	Cholesteryl ester transfer protein precursor (Lipid transfer protein I).

CENPI_HUMAN
NC score	0.050882 (rank : 34)	θ value	0.365318 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q92674, Q5JWZ9, Q96ED0	Gene names	CENPI, FSHPRH1, ICEN19, LRPR1
Domain Architecture	No domain graphic available
Description	Centromere protein I (CENP-I) (Interphase centromere complex protein 19) (Follicle-stimulating hormone primary response protein) (FSH primary response protein 1) (Leucine-rich primary response protein 1).

K0423_MOUSE
NC score	0.045830 (rank : 35)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

CX4NB_MOUSE
NC score	0.029066 (rank : 36)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	O70378	Gene names	Cox4nb, Cox4al, Noc4
Domain Architecture
Description	Neighbor of COX4.

UNG2_HUMAN
NC score	0.022955 (rank : 37)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P22674	Gene names	UNG2
Domain Architecture
Description	Uracil-DNA glycosylase 2 (EC 3.2.2.-) (UDG 2).

RELN_HUMAN
NC score	0.021333 (rank : 38)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	P78509, Q86UJ0, Q86UJ8, Q8NDV0, Q9UDQ2	Gene names	RELN
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-).

E2F3_MOUSE
NC score	0.021131 (rank : 39)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

E2F3_HUMAN
NC score	0.021059 (rank : 40)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	O00716, Q15000, Q9BZ44	Gene names	E2F3, KIAA0075
Domain Architecture
Description	Transcription factor E2F3 (E2F-3).

DMXL2_HUMAN
NC score	0.017818 (rank : 41)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	374	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

KMHN1_HUMAN
NC score	0.017256 (rank : 42)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	950	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

RELN_MOUSE
NC score	0.017044 (rank : 43)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	Q60841, Q9CUA6	Gene names	Reln, Rl
Domain Architecture
Description	Reelin precursor (EC 3.4.21.-) (Reeler protein).

SCYL2_MOUSE
NC score	0.015531 (rank : 44)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	603	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

EVPL_MOUSE
NC score	0.015055 (rank : 45)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	952	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

SMC4_HUMAN
NC score	0.014501 (rank : 46)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	937	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

APBA1_HUMAN
NC score	0.014443 (rank : 47)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	325	Shared Neighborhood Hits	2
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

UN93B_MOUSE
NC score	0.014107 (rank : 48)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCW4, O89077, Q710D2, Q8CIK1, Q8R3D0	Gene names	Unc93b1, Unc93b
Domain Architecture	No domain graphic available
Description	UNC93 homolog B1 (UNC-93B protein).

PRPF3_HUMAN
NC score	0.014101 (rank : 49)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

PRPF3_MOUSE
NC score	0.013964 (rank : 50)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

ACSL1_HUMAN
NC score	0.013541 (rank : 51)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P33121, P41215, Q8N8V7, Q8TA99	Gene names	ACSL1, FACL1, FACL2, LACS, LACS1, LACS2
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase 1) (Long-chain fatty acid CoA ligase 2) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Acyl-CoA synthetase 1) (ACS1) (Palmitoyl-CoA ligase 2).

PFTB_MOUSE
NC score	0.013096 (rank : 52)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2I1	Gene names	Fntb
Domain Architecture	No domain graphic available
Description	Protein farnesyltransferase subunit beta (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) (FTase-beta).

CREM_MOUSE
NC score	0.012928 (rank : 53)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	P27699, P27698	Gene names	Crem
Domain Architecture
Description	cAMP-responsive element modulator.

DMXL1_HUMAN
NC score	0.012894 (rank : 54)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	259	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

FBX41_MOUSE
NC score	0.012823 (rank : 55)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	430	Shared Neighborhood Hits	8
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

RBBP8_HUMAN
NC score	0.012731 (rank : 56)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	476	Shared Neighborhood Hits	12
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

SCYL2_HUMAN
NC score	0.012547 (rank : 57)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	632	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

FBX41_HUMAN
NC score	0.012294 (rank : 58)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	475	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

RHPN1_HUMAN
NC score	0.011784 (rank : 59)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

CU056_HUMAN
NC score	0.011578 (rank : 60)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0A9, Q9NSE5	Gene names	C21orf56
Domain Architecture	No domain graphic available
Description	Putative protein C21orf56.

ENSA_HUMAN
NC score	0.011439 (rank : 61)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O43768, Q9NRZ0	Gene names	ENSA
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

FZD6_MOUSE
NC score	0.011381 (rank : 62)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

FAF1_MOUSE
NC score	0.011079 (rank : 63)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	P54731	Gene names	Faf1
Domain Architecture
Description	FAS-associated factor 1 (Protein FAF1).

RENT2_HUMAN
NC score	0.010058 (rank : 64)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	618	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

UTP20_HUMAN
NC score	0.010056 (rank : 65)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O75691, Q9H3H4	Gene names	UTP20, DRIM
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Protein Key-1A6) (Novel nucleolar protein 73) (NNP73).

MYO1B_MOUSE
NC score	0.009817 (rank : 66)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

CUL3_MOUSE
NC score	0.009648 (rank : 67)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

CUL3_HUMAN
NC score	0.009643 (rank : 68)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

TRI32_MOUSE
NC score	0.008937 (rank : 69)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI32_HUMAN
NC score	0.008899 (rank : 70)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	264	Shared Neighborhood Hits	3
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

NMNA2_MOUSE
NC score	0.008788 (rank : 71)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BNJ3	Gene names	Nmnat2, Kiaa0479
Domain Architecture
Description	Nicotinamide mononucleotide adenylyltransferase 2 (EC 2.7.7.1) (NMN adenylyltransferase 2).

TTC12_HUMAN
NC score	0.008002 (rank : 72)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H892, Q8N5H9, Q9NWY3	Gene names	TTC12
Domain Architecture
Description	Tetratricopeptide repeat protein 12 (TPR repeat protein 12).

GBF1_HUMAN
NC score	0.007673 (rank : 73)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	142	Shared Neighborhood Hits	2
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

PLD1_MOUSE
NC score	0.007547 (rank : 74)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z280, O35911	Gene names	Pld1
Domain Architecture
Description	Phospholipase D1 (EC 3.1.4.4) (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (mPLD1).

UB2L3_HUMAN
NC score	0.007520 (rank : 75)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P68036, P51966, P70653, Q9HAV1	Gene names	UBE2L3, UBCE7, UBCH7
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 L3 (EC 6.3.2.19) (Ubiquitin-protein ligase L3) (Ubiquitin carrier protein L3) (UbcH7) (E2-F1) (L-UBC).

UB2L3_MOUSE
NC score	0.007520 (rank : 76)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P68037, P51966, P70653, Q9HAV1	Gene names	Ube2l3, Ubce7
Domain Architecture	No domain graphic available
Description	Ubiquitin-conjugating enzyme E2 L3 (EC 6.3.2.19) (Ubiquitin-protein ligase L3) (Ubiquitin carrier protein L3) (UbcM4).

CLH2_HUMAN
NC score	0.007181 (rank : 77)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P53675, Q14017, Q15808, Q15809	Gene names	CLTCL1, CLH22, CLTCL, CLTD
Domain Architecture
Description	Clathrin heavy chain 2 (CLH-22).

ZDHC5_HUMAN
NC score	0.006397 (rank : 78)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C0B5, Q6ZMF0, Q8TAK8, Q9H923, Q9UFI7	Gene names	ZDHHC5, KIAA1748, ZNF375
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375).

ZDHC5_MOUSE
NC score	0.006374 (rank : 79)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDZ4, Q69ZB5, Q8R2X7	Gene names	Zdhhc5, Kiaa1748
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5).

LRBA_HUMAN
NC score	0.006354 (rank : 80)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	196	Shared Neighborhood Hits	6
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

CASP8_HUMAN
NC score	0.006049 (rank : 81)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81	Gene names	CASP8, MCH5
Domain Architecture
Description	Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].

DDX54_MOUSE
NC score	0.005503 (rank : 82)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

MAGB2_HUMAN
NC score	0.005236 (rank : 83)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	O15479, O75860	Gene names	MAGEB2
Domain Architecture
Description	Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2).

DDX54_HUMAN
NC score	0.005050 (rank : 84)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

KIF3B_MOUSE
NC score	0.004364 (rank : 85)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	533	Shared Neighborhood Hits	8
SwissProt Accessions	Q61771	Gene names	Kif3b
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B).

TEP1_MOUSE
NC score	0.003810 (rank : 86)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	344	Shared Neighborhood Hits	4
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

CENPE_HUMAN
NC score	0.003463 (rank : 87)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	2060	Shared Neighborhood Hits	23
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

SEM6D_HUMAN
NC score	0.003219 (rank : 88)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

LIPA1_HUMAN
NC score	0.003195 (rank : 89)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	1294	Shared Neighborhood Hits	14
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

EEA1_MOUSE
NC score	0.002503 (rank : 90)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	1637	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RIT1_HUMAN
NC score	0.001872 (rank : 91)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	265	Shared Neighborhood Hits	3
SwissProt Accessions	Q92963, O00646, O00720	Gene names	RIT1, RIBB, RIT, ROC1
Domain Architecture
Description	GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1).

RIT1_MOUSE
NC score	0.001866 (rank : 92)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	266	Shared Neighborhood Hits	3
SwissProt Accessions	P70426	Gene names	Rit1, Rit
Domain Architecture
Description	GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1).

SLK_HUMAN
NC score	-0.002720 (rank : 93)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	1775	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).