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Network neighborhood for query Sequence : CASP8_HUMAN

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CASP8_HUMAN
 
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
Rank Plots


Hits sorted by θ


CASP8_HUMAN
 
θ value 0 (rank : 1) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 62 Target Neighborhood Hits 62 Shared Neighborhood Hits 62
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP8_MOUSE
 
θ value 1.3161e-184 (rank : 2) NC score 0.989068 (rank : 2)
Query Neighborhood Hits 62 Target Neighborhood Hits 57 Shared Neighborhood Hits 32
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASPA_HUMAN
 
θ value 9.76566e-63 (rank : 3) NC score 0.943414 (rank : 3)
Query Neighborhood Hits 62 Target Neighborhood Hits 53 Shared Neighborhood Hits 28
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASP7_MOUSE
 
θ value 2.67181e-44 (rank : 4) NC score 0.907048 (rank : 4)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP7_HUMAN
 
θ value 1.98146e-39 (rank : 5) NC score 0.903133 (rank : 5)
Query Neighborhood Hits 62 Target Neighborhood Hits 26 Shared Neighborhood Hits 22
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP3_HUMAN
 
θ value 9.83387e-39 (rank : 6) NC score 0.897227 (rank : 7)
Query Neighborhood Hits 62 Target Neighborhood Hits 27 Shared Neighborhood Hits 22
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP3_MOUSE
 
θ value 1.28434e-38 (rank : 7) NC score 0.897902 (rank : 6)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP9_HUMAN
 
θ value 6.17384e-33 (rank : 8) NC score 0.881557 (rank : 8)
Query Neighborhood Hits 62 Target Neighborhood Hits 33 Shared Neighborhood Hits 22
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CFLAR_HUMAN
 
θ value 1.0531e-32 (rank : 9) NC score 0.784602 (rank : 15)
Query Neighborhood Hits 62 Target Neighborhood Hits 47 Shared Neighborhood Hits 25
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CASP6_HUMAN
 
θ value 6.38894e-30 (rank : 10) NC score 0.880604 (rank : 9)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP6_MOUSE
 
θ value 1.4233e-29 (rank : 11) NC score 0.880512 (rank : 10)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP2_HUMAN
 
θ value 1.12775e-26 (rank : 12) NC score 0.832280 (rank : 11)
Query Neighborhood Hits 62 Target Neighborhood Hits 31 Shared Neighborhood Hits 22
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CFLAR_MOUSE
 
θ value 2.77775e-25 (rank : 13) NC score 0.750082 (rank : 16)
Query Neighborhood Hits 62 Target Neighborhood Hits 32 Shared Neighborhood Hits 21
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CASP2_MOUSE
 
θ value 3.62785e-25 (rank : 14) NC score 0.829102 (rank : 12)
Query Neighborhood Hits 62 Target Neighborhood Hits 34 Shared Neighborhood Hits 22
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASPE_HUMAN
 
θ value 5.07402e-19 (rank : 15) NC score 0.800064 (rank : 13)
Query Neighborhood Hits 62 Target Neighborhood Hits 26 Shared Neighborhood Hits 21
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASPE_MOUSE
 
θ value 1.52774e-15 (rank : 16) NC score 0.798897 (rank : 14)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASP4_MOUSE
 
θ value 3.52202e-12 (rank : 17) NC score 0.634668 (rank : 18)
Query Neighborhood Hits 62 Target Neighborhood Hits 28 Shared Neighborhood Hits 22
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
CASP1_MOUSE
 
θ value 4.59992e-12 (rank : 18) NC score 0.645743 (rank : 17)
Query Neighborhood Hits 62 Target Neighborhood Hits 38 Shared Neighborhood Hits 22
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP1_HUMAN
 
θ value 1.9326e-10 (rank : 19) NC score 0.629107 (rank : 19)
Query Neighborhood Hits 62 Target Neighborhood Hits 41 Shared Neighborhood Hits 22
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP5_HUMAN
 
θ value 1.06045e-08 (rank : 20) NC score 0.623138 (rank : 20)
Query Neighborhood Hits 62 Target Neighborhood Hits 28 Shared Neighborhood Hits 21
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASP4_HUMAN
 
θ value 1.29631e-06 (rank : 21) NC score 0.595047 (rank : 21)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 21
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
FADD_HUMAN
 
θ value 1.09739e-05 (rank : 22) NC score 0.296855 (rank : 23)
Query Neighborhood Hits 62 Target Neighborhood Hits 20 Shared Neighborhood Hits 7
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
FADD_MOUSE
 
θ value 3.19293e-05 (rank : 23) NC score 0.273121 (rank : 24)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 9
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
CASPC_MOUSE
 
θ value 0.000270298 (rank : 24) NC score 0.589672 (rank : 22)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
PEA15_MOUSE
 
θ value 0.00175202 (rank : 25) NC score 0.199284 (rank : 25)
Query Neighborhood Hits 62 Target Neighborhood Hits 7 Shared Neighborhood Hits 6
SwissProt Accessions Q62048, Q3U5N7 Gene names Pea15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15.
PEA15_HUMAN
 
θ value 0.00228821 (rank : 26) NC score 0.198081 (rank : 26)
Query Neighborhood Hits 62 Target Neighborhood Hits 10 Shared Neighborhood Hits 6
SwissProt Accessions Q15121, O00511 Gene names PEA15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).
TRIPB_HUMAN
 
θ value 0.0431538 (rank : 27) NC score 0.031613 (rank : 35)
Query Neighborhood Hits 62 Target Neighborhood Hits 1587 Shared Neighborhood Hits 31
SwissProt Accessions Q15643, O14689, O15154, O95949 Gene names TRIP11, CEV14
Domain
Architecture

No domain graphic available

Description Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).
PEPL_MOUSE
 
θ value 0.21417 (rank : 28) NC score 0.032791 (rank : 33)
Query Neighborhood Hits 62 Target Neighborhood Hits 1105 Shared Neighborhood Hits 25
SwissProt Accessions Q9R269, O70231, Q9CUT1, Q9JLZ7 Gene names Ppl
Domain
Architecture
Description Periplakin.
CROCC_MOUSE
 
θ value 0.279714 (rank : 29) NC score 0.028939 (rank : 36)
Query Neighborhood Hits 62 Target Neighborhood Hits 1460 Shared Neighborhood Hits 27
SwissProt Accessions Q8CJ40, Q7TQL2, Q80U01, Q8R0B9 Gene names Crocc, Kiaa0445
Domain
Architecture

No domain graphic available

Description Rootletin (Ciliary rootlet coiled-coil protein).
DESP_HUMAN
 
θ value 0.279714 (rank : 30) NC score 0.026010 (rank : 38)
Query Neighborhood Hits 62 Target Neighborhood Hits 1470 Shared Neighborhood Hits 28
SwissProt Accessions P15924, O75993, Q14189, Q9UHN4 Gene names DSP
Domain
Architecture
Description Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).
MRIP_HUMAN
 
θ value 0.365318 (rank : 31) NC score 0.043238 (rank : 31)
Query Neighborhood Hits 62 Target Neighborhood Hits 578 Shared Neighborhood Hits 22
SwissProt Accessions Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40 Gene names MRIP, KIAA0864, RHOIP3
Domain
Architecture

No domain graphic available

Description Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).
MRIP_MOUSE
 
θ value 0.365318 (rank : 32) NC score 0.043518 (rank : 30)
Query Neighborhood Hits 62 Target Neighborhood Hits 569 Shared Neighborhood Hits 23
SwissProt Accessions P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8 Gene names Mrip, Kiaa0864, Rhoip3
Domain
Architecture
Description Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).
PEPL_HUMAN
 
θ value 0.47712 (rank : 33) NC score 0.032201 (rank : 34)
Query Neighborhood Hits 62 Target Neighborhood Hits 1141 Shared Neighborhood Hits 26
SwissProt Accessions O60437, O60314, O60454 Gene names PPL, KIAA0568
Domain
Architecture
Description Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).
MYH10_HUMAN
 
θ value 0.813845 (rank : 34) NC score 0.016024 (rank : 49)
Query Neighborhood Hits 62 Target Neighborhood Hits 1620 Shared Neighborhood Hits 28
SwissProt Accessions P35580, Q16087 Gene names MYH10
Domain
Architecture
Description Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).
CROCC_HUMAN
 
θ value 1.06291 (rank : 35) NC score 0.024702 (rank : 39)
Query Neighborhood Hits 62 Target Neighborhood Hits 1409 Shared Neighborhood Hits 27
SwissProt Accessions Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7 Gene names CROCC, KIAA0445
Domain
Architecture

No domain graphic available

Description Rootletin (Ciliary rootlet coiled-coil protein).
MKL2_HUMAN
 
θ value 1.06291 (rank : 36) NC score 0.026324 (rank : 37)
Query Neighborhood Hits 62 Target Neighborhood Hits 274 Shared Neighborhood Hits 11
SwissProt Accessions Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226 Gene names MKL2, KIAA1243, MRTFB
Domain
Architecture
Description MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).
ROCK1_HUMAN
 
θ value 1.06291 (rank : 37) NC score 0.008439 (rank : 58)
Query Neighborhood Hits 62 Target Neighborhood Hits 2000 Shared Neighborhood Hits 25
SwissProt Accessions Q13464 Gene names ROCK1
Domain
Architecture
Description Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).
DEDD_MOUSE
 
θ value 1.81305 (rank : 38) NC score 0.049328 (rank : 28)
Query Neighborhood Hits 62 Target Neighborhood Hits 29 Shared Neighborhood Hits 5
SwissProt Accessions Q9Z1L3, Q7TQH8, Q9R227 Gene names Dedd
Domain
Architecture
Description Death effector domain-containing protein (DEDPro1).
MYH10_MOUSE
 
θ value 1.81305 (rank : 39) NC score 0.015549 (rank : 50)
Query Neighborhood Hits 62 Target Neighborhood Hits 1612 Shared Neighborhood Hits 28
SwissProt Accessions Q61879, Q5SV63 Gene names Myh10
Domain
Architecture

No domain graphic available

Description Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).
DEDD_HUMAN
 
θ value 2.36792 (rank : 40) NC score 0.048133 (rank : 29)
Query Neighborhood Hits 62 Target Neighborhood Hits 40 Shared Neighborhood Hits 5
SwissProt Accessions O75618, O60737 Gene names DEDD, DEDPRO1, DEFT
Domain
Architecture
Description Death effector domain-containing protein (Death effector domain- containing testicular molecule) (DEDPro1) (FLDED-1).
GA2L1_MOUSE
 
θ value 2.36792 (rank : 41) NC score 0.016129 (rank : 48)
Query Neighborhood Hits 62 Target Neighborhood Hits 114 Shared Neighborhood Hits 3
SwissProt Accessions Q8JZP9, Q5SVG0, Q8K573 Gene names Gas2l1
Domain
Architecture

No domain graphic available

Description GAS2-like protein 1 (Growth arrest-specific 2-like 1).
ROCK1_MOUSE
 
θ value 2.36792 (rank : 42) NC score 0.008699 (rank : 57)
Query Neighborhood Hits 62 Target Neighborhood Hits 2126 Shared Neighborhood Hits 27
SwissProt Accessions P70335, Q8C3G4, Q8C7H0 Gene names Rock1
Domain
Architecture
Description Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).
BPA1_MOUSE
 
θ value 3.0926 (rank : 43) NC score 0.022368 (rank : 41)
Query Neighborhood Hits 62 Target Neighborhood Hits 1477 Shared Neighborhood Hits 29
SwissProt Accessions Q91ZU6, Q91ZU7 Gene names Dst, Bpag1
Domain
Architecture
Description Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).
CIR_HUMAN
 
θ value 3.0926 (rank : 44) NC score 0.017836 (rank : 46)
Query Neighborhood Hits 62 Target Neighborhood Hits 249 Shared Neighborhood Hits 6
SwissProt Accessions Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2 Gene names CIR
Domain
Architecture

No domain graphic available

Description CBF1-interacting corepressor (Recepin).
DEDD2_MOUSE
 
θ value 3.0926 (rank : 45) NC score 0.035978 (rank : 32)
Query Neighborhood Hits 62 Target Neighborhood Hits 14 Shared Neighborhood Hits 5
SwissProt Accessions Q8QZV0, Q569Y9, Q8JZV1 Gene names Dedd2, Flame3
Domain
Architecture

No domain graphic available

Description DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).
MKL2_MOUSE
 
θ value 3.0926 (rank : 46) NC score 0.023228 (rank : 40)
Query Neighborhood Hits 62 Target Neighborhood Hits 269 Shared Neighborhood Hits 8
SwissProt Accessions P59759 Gene names Mkl2, Mrtfb
Domain
Architecture
Description MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).
CENPE_HUMAN
 
θ value 4.03905 (rank : 47) NC score 0.015036 (rank : 51)
Query Neighborhood Hits 62 Target Neighborhood Hits 2060 Shared Neighborhood Hits 31
SwissProt Accessions Q02224 Gene names CENPE
Domain
Architecture
Description Centromeric protein E (CENP-E).
CEP63_HUMAN
 
θ value 5.27518 (rank : 48) NC score 0.021901 (rank : 42)
Query Neighborhood Hits 62 Target Neighborhood Hits 1005 Shared Neighborhood Hits 29
SwissProt Accessions Q96MT8, Q96CR0, Q9H8F5, Q9H8N0 Gene names CEP63
Domain
Architecture

No domain graphic available

Description Centrosomal protein of 63 kDa (Cep63 protein).
ICAL_HUMAN
 
θ value 5.27518 (rank : 49) NC score 0.011921 (rank : 56)
Query Neighborhood Hits 62 Target Neighborhood Hits 275 Shared Neighborhood Hits 3
SwissProt Accessions P20810, O95360, Q96D08, Q9H1Z5 Gene names CAST
Domain
Architecture
Description Calpastatin (Calpain inhibitor) (Sperm BS-17 component).
LRC45_HUMAN
 
θ value 5.27518 (rank : 50) NC score 0.019292 (rank : 43)
Query Neighborhood Hits 62 Target Neighborhood Hits 933 Shared Neighborhood Hits 26
SwissProt Accessions Q96CN5 Gene names LRRC45
Domain
Architecture

No domain graphic available

Description Leucine-rich repeat-containing protein 45.
TRI39_MOUSE
 
θ value 5.27518 (rank : 51) NC score 0.005211 (rank : 63)
Query Neighborhood Hits 62 Target Neighborhood Hits 691 Shared Neighborhood Hits 24
SwissProt Accessions Q9ESN2, Q8BPR5, Q8K0F7 Gene names Trim39, Rnf23, Tfp
Domain
Architecture
Description Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).
AZI1_MOUSE
 
θ value 6.88961 (rank : 52) NC score 0.018333 (rank : 44)
Query Neighborhood Hits 62 Target Neighborhood Hits 990 Shared Neighborhood Hits 27
SwissProt Accessions Q62036 Gene names Azi1, Az1, Azi
Domain
Architecture
Description 5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).
MRCKA_HUMAN
 
θ value 6.88961 (rank : 53) NC score 0.005825 (rank : 62)
Query Neighborhood Hits 62 Target Neighborhood Hits 1999 Shared Neighborhood Hits 24
SwissProt Accessions Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646 Gene names CDC42BPA
Domain
Architecture

No domain graphic available

Description Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).
ZN622_HUMAN
 
θ value 6.88961 (rank : 54) NC score 0.012388 (rank : 55)
Query Neighborhood Hits 62 Target Neighborhood Hits 62 Shared Neighborhood Hits 3
SwissProt Accessions Q969S3 Gene names ZNF622, ZPR9
Domain
Architecture

No domain graphic available

Description Zinc finger protein 622 (Zinc finger-like protein 9).
BRDT_HUMAN
 
θ value 8.99809 (rank : 55) NC score 0.007079 (rank : 60)
Query Neighborhood Hits 62 Target Neighborhood Hits 280 Shared Neighborhood Hits 11
SwissProt Accessions Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6 Gene names BRDT
Domain
Architecture

No domain graphic available

Description Bromodomain testis-specific protein (RING3-like protein).
EP15_MOUSE
 
θ value 8.99809 (rank : 56) NC score 0.014871 (rank : 52)
Query Neighborhood Hits 62 Target Neighborhood Hits 820 Shared Neighborhood Hits 24
SwissProt Accessions P42567 Gene names Eps15
Domain
Architecture
Description Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).
GOGB1_HUMAN
 
θ value 8.99809 (rank : 57) NC score 0.016892 (rank : 47)
Query Neighborhood Hits 62 Target Neighborhood Hits 2297 Shared Neighborhood Hits 30
SwissProt Accessions Q14789, Q14398 Gene names GOLGB1
Domain
Architecture
Description Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).
ITSN2_HUMAN
 
θ value 8.99809 (rank : 58) NC score 0.008401 (rank : 59)
Query Neighborhood Hits 62 Target Neighborhood Hits 1173 Shared Neighborhood Hits 23
SwissProt Accessions Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4 Gene names ITSN2, KIAA1256, SH3D1B, SWAP
Domain
Architecture
Description Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).
MYH11_HUMAN
 
θ value 8.99809 (rank : 59) NC score 0.014294 (rank : 53)
Query Neighborhood Hits 62 Target Neighborhood Hits 1806 Shared Neighborhood Hits 26
SwissProt Accessions P35749, O00396, O94944, P78422 Gene names MYH11, KIAA0866
Domain
Architecture
Description Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).
NIN_HUMAN
 
θ value 8.99809 (rank : 60) NC score 0.017963 (rank : 45)
Query Neighborhood Hits 62 Target Neighborhood Hits 1416 Shared Neighborhood Hits 26
SwissProt Accessions Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61 Gene names NIN, KIAA1565
Domain
Architecture

No domain graphic available

Description Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).
PRKDC_HUMAN
 
θ value 8.99809 (rank : 61) NC score 0.006049 (rank : 61)
Query Neighborhood Hits 62 Target Neighborhood Hits 93 Shared Neighborhood Hits 3
SwissProt Accessions P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3 Gene names PRKDC
Domain
Architecture
Description DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).
U2AFM_MOUSE
 
θ value 8.99809 (rank : 62) NC score 0.012450 (rank : 54)
Query Neighborhood Hits 62 Target Neighborhood Hits 543 Shared Neighborhood Hits 20
SwissProt Accessions Q62377 Gene names Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain
Architecture
Description U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).
ICBR_HUMAN
 
θ value θ > 10 (rank : 63) NC score 0.104955 (rank : 27)
Query Neighborhood Hits 62 Target Neighborhood Hits 11 Shared Neighborhood Hits 3
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.

Hits sorted by NC score


CASP8_HUMAN
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 1)
Query Neighborhood Hits 62 Target Neighborhood Hits 62 Shared Neighborhood Hits 62
SwissProt Accessions Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 Gene names CASP8, MCH5
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASP8_MOUSE
 
NC score 0.989068 (rank : 2) θ value 1.3161e-184 (rank : 2)
Query Neighborhood Hits 62 Target Neighborhood Hits 57 Shared Neighborhood Hits 32
SwissProt Accessions O89110, O35669 Gene names Casp8
Domain
Architecture
Description Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10].
CASPA_HUMAN
 
NC score 0.943414 (rank : 3) θ value 9.76566e-63 (rank : 3)
Query Neighborhood Hits 62 Target Neighborhood Hits 53 Shared Neighborhood Hits 28
SwissProt Accessions Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 Gene names CASP10, MCH4
Domain
Architecture
Description Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12].
CASP7_MOUSE
 
NC score 0.907048 (rank : 4) θ value 2.67181e-44 (rank : 4)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P97864, O08669 Gene names Casp7, Lice2, Mch3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP7_HUMAN
 
NC score 0.903133 (rank : 5) θ value 1.98146e-39 (rank : 5)
Query Neighborhood Hits 62 Target Neighborhood Hits 26 Shared Neighborhood Hits 22
SwissProt Accessions P55210, Q13364, Q96BA0 Gene names CASP7, MCH3
Domain
Architecture
Description Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11].
CASP3_MOUSE
 
NC score 0.897902 (rank : 6) θ value 1.28434e-38 (rank : 7)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions P70677, O08668, Q8CHV5, Q9QWI4 Gene names Casp3, Cpp32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP3_HUMAN
 
NC score 0.897227 (rank : 7) θ value 9.83387e-39 (rank : 6)
Query Neighborhood Hits 62 Target Neighborhood Hits 27 Shared Neighborhood Hits 22
SwissProt Accessions P42574, Q96AN1, Q96KP2 Gene names CASP3, CPP32
Domain
Architecture
Description Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit].
CASP9_HUMAN
 
NC score 0.881557 (rank : 8) θ value 6.17384e-33 (rank : 8)
Query Neighborhood Hits 62 Target Neighborhood Hits 33 Shared Neighborhood Hits 22
SwissProt Accessions P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 Gene names CASP9, MCH6
Domain
Architecture
Description Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10].
CASP6_HUMAN
 
NC score 0.880604 (rank : 9) θ value 6.38894e-30 (rank : 10)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions P55212, Q9BQE7 Gene names CASP6, MCH2
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP6_MOUSE
 
NC score 0.880512 (rank : 10) θ value 1.4233e-29 (rank : 11)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08738 Gene names Casp6
Domain
Architecture
Description Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11].
CASP2_HUMAN
 
NC score 0.832280 (rank : 11) θ value 1.12775e-26 (rank : 12)
Query Neighborhood Hits 62 Target Neighborhood Hits 31 Shared Neighborhood Hits 22
SwissProt Accessions P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 Gene names CASP2, ICH1
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASP2_MOUSE
 
NC score 0.829102 (rank : 12) θ value 3.62785e-25 (rank : 14)
Query Neighborhood Hits 62 Target Neighborhood Hits 34 Shared Neighborhood Hits 22
SwissProt Accessions P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 Gene names Casp2, Ich1, Nedd-2, Nedd2
Domain
Architecture
Description Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].
CASPE_HUMAN
 
NC score 0.800064 (rank : 13) θ value 5.07402e-19 (rank : 15)
Query Neighborhood Hits 62 Target Neighborhood Hits 26 Shared Neighborhood Hits 21
SwissProt Accessions P31944, O95823, Q3SYC9 Gene names CASP14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CASPE_MOUSE
 
NC score 0.798897 (rank : 14) θ value 1.52774e-15 (rank : 16)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 22
SwissProt Accessions O89094 Gene names Casp14
Domain
Architecture
Description Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2].
CFLAR_HUMAN
 
NC score 0.784602 (rank : 15) θ value 1.0531e-32 (rank : 9)
Query Neighborhood Hits 62 Target Neighborhood Hits 47 Shared Neighborhood Hits 25
SwissProt Accessions O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 Gene names CFLAR, CASH, CLARP, MRIT
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CFLAR_MOUSE
 
NC score 0.750082 (rank : 16) θ value 2.77775e-25 (rank : 13)
Query Neighborhood Hits 62 Target Neighborhood Hits 32 Shared Neighborhood Hits 21
SwissProt Accessions O35732, O35707, O35733 Gene names Cflar, Cash
Domain
Architecture
Description CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].
CASP1_MOUSE
 
NC score 0.645743 (rank : 17) θ value 4.59992e-12 (rank : 18)
Query Neighborhood Hits 62 Target Neighborhood Hits 38 Shared Neighborhood Hits 22
SwissProt Accessions P29452 Gene names Casp1, Il1bc
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP4_MOUSE
 
NC score 0.634668 (rank : 18) θ value 3.52202e-12 (rank : 17)
Query Neighborhood Hits 62 Target Neighborhood Hits 28 Shared Neighborhood Hits 22
SwissProt Accessions P70343, O08735 Gene names Casp4, Casp11, Caspl, Ich3
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].
CASP1_HUMAN
 
NC score 0.629107 (rank : 19) θ value 1.9326e-10 (rank : 19)
Query Neighborhood Hits 62 Target Neighborhood Hits 41 Shared Neighborhood Hits 22
SwissProt Accessions P29466, Q9UCN3 Gene names CASP1, IL1BC, IL1BCE
Domain
Architecture
Description Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].
CASP5_HUMAN
 
NC score 0.623138 (rank : 20) θ value 1.06045e-08 (rank : 20)
Query Neighborhood Hits 62 Target Neighborhood Hits 28 Shared Neighborhood Hits 21
SwissProt Accessions P51878 Gene names CASP5, ICH3
Domain
Architecture
Description Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].
CASP4_HUMAN
 
NC score 0.595047 (rank : 21) θ value 1.29631e-06 (rank : 21)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 21
SwissProt Accessions P49662 Gene names CASP4, ICH2
Domain
Architecture
Description Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].
CASPC_MOUSE
 
NC score 0.589672 (rank : 22) θ value 0.000270298 (rank : 24)
Query Neighborhood Hits 62 Target Neighborhood Hits 24 Shared Neighborhood Hits 22
SwissProt Accessions O08736, Q3TT82 Gene names Casp12
Domain
Architecture
Description Caspase-12 precursor (EC 3.4.22.-) (CASP-12).
FADD_HUMAN
 
NC score 0.296855 (rank : 23) θ value 1.09739e-05 (rank : 22)
Query Neighborhood Hits 62 Target Neighborhood Hits 20 Shared Neighborhood Hits 7
SwissProt Accessions Q13158, Q14866 Gene names FADD, MORT1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
FADD_MOUSE
 
NC score 0.273121 (rank : 24) θ value 3.19293e-05 (rank : 23)
Query Neighborhood Hits 62 Target Neighborhood Hits 23 Shared Neighborhood Hits 9
SwissProt Accessions Q61160, Q3TC37, Q61082 Gene names Fadd, Mort1
Domain
Architecture
Description FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).
PEA15_MOUSE
 
NC score 0.199284 (rank : 25) θ value 0.00175202 (rank : 25)
Query Neighborhood Hits 62 Target Neighborhood Hits 7 Shared Neighborhood Hits 6
SwissProt Accessions Q62048, Q3U5N7 Gene names Pea15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15.
PEA15_HUMAN
 
NC score 0.198081 (rank : 26) θ value 0.00228821 (rank : 26)
Query Neighborhood Hits 62 Target Neighborhood Hits 10 Shared Neighborhood Hits 6
SwissProt Accessions Q15121, O00511 Gene names PEA15
Domain
Architecture
Description Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes) (PED).
ICBR_HUMAN
 
NC score 0.104955 (rank : 27) θ value θ > 10 (rank : 63)
Query Neighborhood Hits 62 Target Neighborhood Hits 11 Shared Neighborhood Hits 3
SwissProt Accessions P57730 Gene names ICEBERG
Domain
Architecture
Description Caspase-1 inhibitor Iceberg.
DEDD_MOUSE
 
NC score 0.049328 (rank : 28) θ value 1.81305 (rank : 38)
Query Neighborhood Hits 62 Target Neighborhood Hits 29 Shared Neighborhood Hits 5
SwissProt Accessions Q9Z1L3, Q7TQH8, Q9R227 Gene names Dedd
Domain
Architecture
Description Death effector domain-containing protein (DEDPro1).
DEDD_HUMAN
 
NC score 0.048133 (rank : 29) θ value 2.36792 (rank : 40)
Query Neighborhood Hits 62 Target Neighborhood Hits 40 Shared Neighborhood Hits 5
SwissProt Accessions O75618, O60737 Gene names DEDD, DEDPRO1, DEFT
Domain
Architecture
Description Death effector domain-containing protein (Death effector domain- containing testicular molecule) (DEDPro1) (FLDED-1).
MRIP_MOUSE
 
NC score 0.043518 (rank : 30) θ value 0.365318 (rank : 32)
Query Neighborhood Hits 62 Target Neighborhood Hits 569 Shared Neighborhood Hits 23
SwissProt Accessions P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8 Gene names Mrip, Kiaa0864, Rhoip3
Domain
Architecture
Description Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).
MRIP_HUMAN
 
NC score 0.043238 (rank : 31) θ value 0.365318 (rank : 31)
Query Neighborhood Hits 62 Target Neighborhood Hits 578 Shared Neighborhood Hits 22
SwissProt Accessions Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40 Gene names MRIP, KIAA0864, RHOIP3
Domain
Architecture

No domain graphic available

Description Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).
DEDD2_MOUSE
 
NC score 0.035978 (rank : 32) θ value 3.0926 (rank : 45)
Query Neighborhood Hits 62 Target Neighborhood Hits 14 Shared Neighborhood Hits 5
SwissProt Accessions Q8QZV0, Q569Y9, Q8JZV1 Gene names Dedd2, Flame3
Domain
Architecture

No domain graphic available

Description DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).
PEPL_MOUSE
 
NC score 0.032791 (rank : 33) θ value 0.21417 (rank : 28)
Query Neighborhood Hits 62 Target Neighborhood Hits 1105 Shared Neighborhood Hits 25
SwissProt Accessions Q9R269, O70231, Q9CUT1, Q9JLZ7 Gene names Ppl
Domain
Architecture
Description Periplakin.
PEPL_HUMAN
 
NC score 0.032201 (rank : 34) θ value 0.47712 (rank : 33)
Query Neighborhood Hits 62 Target Neighborhood Hits 1141 Shared Neighborhood Hits 26
SwissProt Accessions O60437, O60314, O60454 Gene names PPL, KIAA0568
Domain
Architecture
Description Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).
TRIPB_HUMAN
 
NC score 0.031613 (rank : 35) θ value 0.0431538 (rank : 27)
Query Neighborhood Hits 62 Target Neighborhood Hits 1587 Shared Neighborhood Hits 31
SwissProt Accessions Q15643, O14689, O15154, O95949 Gene names TRIP11, CEV14
Domain
Architecture

No domain graphic available

Description Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).
CROCC_MOUSE
 
NC score 0.028939 (rank : 36) θ value 0.279714 (rank : 29)
Query Neighborhood Hits 62 Target Neighborhood Hits 1460 Shared Neighborhood Hits 27
SwissProt Accessions Q8CJ40, Q7TQL2, Q80U01, Q8R0B9 Gene names Crocc, Kiaa0445
Domain
Architecture

No domain graphic available

Description Rootletin (Ciliary rootlet coiled-coil protein).
MKL2_HUMAN
 
NC score 0.026324 (rank : 37) θ value 1.06291 (rank : 36)
Query Neighborhood Hits 62 Target Neighborhood Hits 274 Shared Neighborhood Hits 11
SwissProt Accessions Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226 Gene names MKL2, KIAA1243, MRTFB
Domain
Architecture
Description MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).
DESP_HUMAN
 
NC score 0.026010 (rank : 38) θ value 0.279714 (rank : 30)
Query Neighborhood Hits 62 Target Neighborhood Hits 1470 Shared Neighborhood Hits 28
SwissProt Accessions P15924, O75993, Q14189, Q9UHN4 Gene names DSP
Domain
Architecture
Description Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).
CROCC_HUMAN
 
NC score 0.024702 (rank : 39) θ value 1.06291 (rank : 35)
Query Neighborhood Hits 62 Target Neighborhood Hits 1409 Shared Neighborhood Hits 27
SwissProt Accessions Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7 Gene names CROCC, KIAA0445
Domain
Architecture

No domain graphic available

Description Rootletin (Ciliary rootlet coiled-coil protein).
MKL2_MOUSE
 
NC score 0.023228 (rank : 40) θ value 3.0926 (rank : 46)
Query Neighborhood Hits 62 Target Neighborhood Hits 269 Shared Neighborhood Hits 8
SwissProt Accessions P59759 Gene names Mkl2, Mrtfb
Domain
Architecture
Description MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).
BPA1_MOUSE
 
NC score 0.022368 (rank : 41) θ value 3.0926 (rank : 43)
Query Neighborhood Hits 62 Target Neighborhood Hits 1477 Shared Neighborhood Hits 29
SwissProt Accessions Q91ZU6, Q91ZU7 Gene names Dst, Bpag1
Domain
Architecture
Description Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).
CEP63_HUMAN
 
NC score 0.021901 (rank : 42) θ value 5.27518 (rank : 48)
Query Neighborhood Hits 62 Target Neighborhood Hits 1005 Shared Neighborhood Hits 29
SwissProt Accessions Q96MT8, Q96CR0, Q9H8F5, Q9H8N0 Gene names CEP63
Domain
Architecture

No domain graphic available

Description Centrosomal protein of 63 kDa (Cep63 protein).
LRC45_HUMAN
 
NC score 0.019292 (rank : 43) θ value 5.27518 (rank : 50)
Query Neighborhood Hits 62 Target Neighborhood Hits 933 Shared Neighborhood Hits 26
SwissProt Accessions Q96CN5 Gene names LRRC45
Domain
Architecture

No domain graphic available

Description Leucine-rich repeat-containing protein 45.
AZI1_MOUSE
 
NC score 0.018333 (rank : 44) θ value 6.88961 (rank : 52)
Query Neighborhood Hits 62 Target Neighborhood Hits 990 Shared Neighborhood Hits 27
SwissProt Accessions Q62036 Gene names Azi1, Az1, Azi
Domain
Architecture
Description 5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).
NIN_HUMAN
 
NC score 0.017963 (rank : 45) θ value 8.99809 (rank : 60)
Query Neighborhood Hits 62 Target Neighborhood Hits 1416 Shared Neighborhood Hits 26
SwissProt Accessions Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61 Gene names NIN, KIAA1565
Domain
Architecture

No domain graphic available

Description Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).
CIR_HUMAN
 
NC score 0.017836 (rank : 46) θ value 3.0926 (rank : 44)
Query Neighborhood Hits 62 Target Neighborhood Hits 249 Shared Neighborhood Hits 6
SwissProt Accessions Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2 Gene names CIR
Domain
Architecture

No domain graphic available

Description CBF1-interacting corepressor (Recepin).
GOGB1_HUMAN
 
NC score 0.016892 (rank : 47) θ value 8.99809 (rank : 57)
Query Neighborhood Hits 62 Target Neighborhood Hits 2297 Shared Neighborhood Hits 30
SwissProt Accessions Q14789, Q14398 Gene names GOLGB1
Domain
Architecture
Description Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).
GA2L1_MOUSE
 
NC score 0.016129 (rank : 48) θ value 2.36792 (rank : 41)
Query Neighborhood Hits 62 Target Neighborhood Hits 114 Shared Neighborhood Hits 3
SwissProt Accessions Q8JZP9, Q5SVG0, Q8K573 Gene names Gas2l1
Domain
Architecture

No domain graphic available

Description GAS2-like protein 1 (Growth arrest-specific 2-like 1).
MYH10_HUMAN
 
NC score 0.016024 (rank : 49) θ value 0.813845 (rank : 34)
Query Neighborhood Hits 62 Target Neighborhood Hits 1620 Shared Neighborhood Hits 28
SwissProt Accessions P35580, Q16087 Gene names MYH10
Domain
Architecture
Description Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).
MYH10_MOUSE
 
NC score 0.015549 (rank : 50) θ value 1.81305 (rank : 39)
Query Neighborhood Hits 62 Target Neighborhood Hits 1612 Shared Neighborhood Hits 28
SwissProt Accessions Q61879, Q5SV63 Gene names Myh10
Domain
Architecture

No domain graphic available

Description Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).
CENPE_HUMAN
 
NC score 0.015036 (rank : 51) θ value 4.03905 (rank : 47)
Query Neighborhood Hits 62 Target Neighborhood Hits 2060 Shared Neighborhood Hits 31
SwissProt Accessions Q02224 Gene names CENPE
Domain
Architecture
Description Centromeric protein E (CENP-E).
EP15_MOUSE
 
NC score 0.014871 (rank : 52) θ value 8.99809 (rank : 56)
Query Neighborhood Hits 62 Target Neighborhood Hits 820 Shared Neighborhood Hits 24
SwissProt Accessions P42567 Gene names Eps15
Domain
Architecture
Description Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).
MYH11_HUMAN
 
NC score 0.014294 (rank : 53) θ value 8.99809 (rank : 59)
Query Neighborhood Hits 62 Target Neighborhood Hits 1806 Shared Neighborhood Hits 26
SwissProt Accessions P35749, O00396, O94944, P78422 Gene names MYH11, KIAA0866
Domain
Architecture
Description Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).
U2AFM_MOUSE
 
NC score 0.012450 (rank : 54) θ value 8.99809 (rank : 62)
Query Neighborhood Hits 62 Target Neighborhood Hits 543 Shared Neighborhood Hits 20
SwissProt Accessions Q62377 Gene names Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain
Architecture
Description U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).
ZN622_HUMAN
 
NC score 0.012388 (rank : 55) θ value 6.88961 (rank : 54)
Query Neighborhood Hits 62 Target Neighborhood Hits 62 Shared Neighborhood Hits 3
SwissProt Accessions Q969S3 Gene names ZNF622, ZPR9
Domain
Architecture

No domain graphic available

Description Zinc finger protein 622 (Zinc finger-like protein 9).
ICAL_HUMAN
 
NC score 0.011921 (rank : 56) θ value 5.27518 (rank : 49)
Query Neighborhood Hits 62 Target Neighborhood Hits 275 Shared Neighborhood Hits 3
SwissProt Accessions P20810, O95360, Q96D08, Q9H1Z5 Gene names CAST
Domain
Architecture
Description Calpastatin (Calpain inhibitor) (Sperm BS-17 component).
ROCK1_MOUSE
 
NC score 0.008699 (rank : 57) θ value 2.36792 (rank : 42)
Query Neighborhood Hits 62 Target Neighborhood Hits 2126 Shared Neighborhood Hits 27
SwissProt Accessions P70335, Q8C3G4, Q8C7H0 Gene names Rock1
Domain
Architecture
Description Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).
ROCK1_HUMAN
 
NC score 0.008439 (rank : 58) θ value 1.06291 (rank : 37)
Query Neighborhood Hits 62 Target Neighborhood Hits 2000 Shared Neighborhood Hits 25
SwissProt Accessions Q13464 Gene names ROCK1
Domain
Architecture
Description Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).
ITSN2_HUMAN
 
NC score 0.008401 (rank : 59) θ value 8.99809 (rank : 58)
Query Neighborhood Hits 62 Target Neighborhood Hits 1173 Shared Neighborhood Hits 23
SwissProt Accessions Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4 Gene names ITSN2, KIAA1256, SH3D1B, SWAP
Domain
Architecture
Description Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).
BRDT_HUMAN
 
NC score 0.007079 (rank : 60) θ value 8.99809 (rank : 55)
Query Neighborhood Hits 62 Target Neighborhood Hits 280 Shared Neighborhood Hits 11
SwissProt Accessions Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6 Gene names BRDT
Domain
Architecture

No domain graphic available

Description Bromodomain testis-specific protein (RING3-like protein).
PRKDC_HUMAN
 
NC score 0.006049 (rank : 61) θ value 8.99809 (rank : 61)
Query Neighborhood Hits 62 Target Neighborhood Hits 93 Shared Neighborhood Hits 3
SwissProt Accessions P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3 Gene names PRKDC
Domain
Architecture
Description DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).
MRCKA_HUMAN
 
NC score 0.005825 (rank : 62) θ value 6.88961 (rank : 53)
Query Neighborhood Hits 62 Target Neighborhood Hits 1999 Shared Neighborhood Hits 24
SwissProt Accessions Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646 Gene names CDC42BPA
Domain
Architecture

No domain graphic available

Description Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).
TRI39_MOUSE
 
NC score 0.005211 (rank : 63) θ value 5.27518 (rank : 51)
Query Neighborhood Hits 62 Target Neighborhood Hits 691 Shared Neighborhood Hits 24
SwissProt Accessions Q9ESN2, Q8BPR5, Q8K0F7 Gene names Trim39, Rnf23, Tfp
Domain
Architecture
Description Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).