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ICBR_HUMAN
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| SwissProt Accessions | P57730 | Gene names | ICEBERG | |||
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Domain Architecture |
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| Description | Caspase-1 inhibitor Iceberg. | |||||
| Rank Plots |
Jump to hits sorted by NC score
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ICBR_HUMAN
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| θ value | 2.85459e-46 (rank : 1) | NC score | 0.999962 (rank : 1) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 11 | Shared Neighborhood Hits | 11 | |
| SwissProt Accessions | P57730 | Gene names | ICEBERG | |||
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Domain Architecture |
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| Description | Caspase-1 inhibitor Iceberg. | |||||
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CASP1_HUMAN
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| θ value | 3.51386e-20 (rank : 2) | NC score | 0.507057 (rank : 2) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 41 | Shared Neighborhood Hits | 9 | |
| SwissProt Accessions | P29466, Q9UCN3 | Gene names | CASP1, IL1BC, IL1BCE | |||
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Domain Architecture |
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| Description | Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit]. | |||||
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CASP1_MOUSE
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| θ value | 2.7842e-17 (rank : 3) | NC score | 0.495282 (rank : 3) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 38 | Shared Neighborhood Hits | 10 | |
| SwissProt Accessions | P29452 | Gene names | Casp1, Il1bc | |||
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Domain Architecture |
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| Description | Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit]. | |||||
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CARD6_HUMAN
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| θ value | 0.00509761 (rank : 4) | NC score | 0.209998 (rank : 8) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 145 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q9BX69 | Gene names | CARD6 | |||
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Domain Architecture |
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| Description | Caspase recruitment domain-containing protein 6. | |||||
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BIRC3_MOUSE
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| θ value | 0.0330416 (rank : 5) | NC score | 0.066423 (rank : 28) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 113 | Shared Neighborhood Hits | 2 | |
| SwissProt Accessions | O08863 | Gene names | Birc3, Birc2, Iap1 | |||
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Domain Architecture |
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| Description | Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1). | |||||
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CAR12_HUMAN
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| θ value | 0.163984 (rank : 6) | NC score | 0.113633 (rank : 20) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 132 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q9NPP4, Q96J81, Q96J82, Q96J83 | Gene names | CARD12, CLAN, CLAN1 | |||
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Domain Architecture |
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| Description | Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein). | |||||
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CARD8_HUMAN
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| θ value | 0.813845 (rank : 7) | NC score | 0.167277 (rank : 10) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 22 | Shared Neighborhood Hits | 6 | |
| SwissProt Accessions | Q9Y2G2, Q6PGP8, Q96P82 | Gene names | CARD8, KIAA0955, NDPP1 | |||
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Domain Architecture |
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| Description | Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN). | |||||
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CAR15_MOUSE
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| θ value | 3.0926 (rank : 8) | NC score | 0.057373 (rank : 31) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 93 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q8K3Z0 | Gene names | Card15, Nod2 | |||
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Domain Architecture |
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| Description | Caspase recruitment domain-containing protein 15 (Protein Nod2). | |||||
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CASP4_HUMAN
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| θ value | 3.0926 (rank : 9) | NC score | 0.328938 (rank : 4) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 23 | Shared Neighborhood Hits | 4 | |
| SwissProt Accessions | P49662 | Gene names | CASP4, ICH2 | |||
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Domain Architecture |
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| Description | Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2]. | |||||
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CARD4_HUMAN
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| θ value | 6.88961 (rank : 10) | NC score | 0.047559 (rank : 33) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 102 | Shared Neighborhood Hits | 7 | |
| SwissProt Accessions | Q9Y239, Q8IWF5 | Gene names | CARD4, NOD1 | |||
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Domain Architecture |
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| Description | Caspase recruitment domain-containing protein 4 (Protein Nod1). | |||||
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CAR15_HUMAN
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| θ value | 8.99809 (rank : 11) | NC score | 0.055235 (rank : 32) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 77 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q9HC29, Q96RH5, Q96RH6, Q96RH8 | Gene names | CARD15, IBD1, NOD2 | |||
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Domain Architecture |
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| Description | Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1). | |||||
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BIRC2_HUMAN
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| θ value | θ > 10 (rank : 12) | NC score | 0.067642 (rank : 26) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 142 | Shared Neighborhood Hits | 6 | |
| SwissProt Accessions | Q13490, Q16516, Q4TTG0 | Gene names | BIRC2, API1, IAP2, MIHB | |||
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Domain Architecture |
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| Description | Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B). | |||||
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BIRC2_MOUSE
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| θ value | θ > 10 (rank : 13) | NC score | 0.062826 (rank : 29) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 137 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q62210, O08864 | Gene names | Birc2, Birc3, Iap2 | |||
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Domain Architecture |
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| Description | Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2). | |||||
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BIRC3_HUMAN
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| θ value | θ > 10 (rank : 14) | NC score | 0.061929 (rank : 30) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 133 | Shared Neighborhood Hits | 6 | |
| SwissProt Accessions | Q13489, Q16628, Q9HC27, Q9UP46 | Gene names | BIRC3, API2, IAP1, MIHC | |||
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Domain Architecture |
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| Description | Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2). | |||||
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CASP2_HUMAN
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| θ value | θ > 10 (rank : 15) | NC score | 0.166832 (rank : 11) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 31 | Shared Neighborhood Hits | 4 | |
| SwissProt Accessions | P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 | Gene names | CASP2, ICH1 | |||
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Domain Architecture |
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| Description | Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]. | |||||
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CASP2_MOUSE
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| θ value | θ > 10 (rank : 16) | NC score | 0.170980 (rank : 9) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 34 | Shared Neighborhood Hits | 4 | |
| SwissProt Accessions | P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 | Gene names | Casp2, Ich1, Nedd-2, Nedd2 | |||
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Domain Architecture |
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| Description | Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]. | |||||
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CASP3_HUMAN
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| θ value | θ > 10 (rank : 17) | NC score | 0.132209 (rank : 16) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 27 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P42574, Q96AN1, Q96KP2 | Gene names | CASP3, CPP32 | |||
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Domain Architecture |
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| Description | Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]. | |||||
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CASP3_MOUSE
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| θ value | θ > 10 (rank : 18) | NC score | 0.122761 (rank : 17) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 23 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P70677, O08668, Q8CHV5, Q9QWI4 | Gene names | Casp3, Cpp32 | |||
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Domain Architecture |
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| Description | Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]. | |||||
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CASP4_MOUSE
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| θ value | θ > 10 (rank : 19) | NC score | 0.303031 (rank : 7) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 28 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P70343, O08735 | Gene names | Casp4, Casp11, Caspl, Ich3 | |||
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Domain Architecture |
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| Description | Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20]. | |||||
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CASP5_HUMAN
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| θ value | θ > 10 (rank : 20) | NC score | 0.306669 (rank : 6) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 28 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P51878 | Gene names | CASP5, ICH3 | |||
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Domain Architecture |
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| Description | Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10]. | |||||
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CASP6_HUMAN
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| θ value | θ > 10 (rank : 21) | NC score | 0.120741 (rank : 18) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P55212, Q9BQE7 | Gene names | CASP6, MCH2 | |||
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Domain Architecture |
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| Description | Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11]. | |||||
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CASP6_MOUSE
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| θ value | θ > 10 (rank : 22) | NC score | 0.117149 (rank : 19) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O08738 | Gene names | Casp6 | |||
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Domain Architecture |
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| Description | Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11]. | |||||
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CASP7_HUMAN
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| θ value | θ > 10 (rank : 23) | NC score | 0.107106 (rank : 22) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 26 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P55210, Q13364, Q96BA0 | Gene names | CASP7, MCH3 | |||
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Domain Architecture |
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| Description | Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11]. | |||||
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CASP7_MOUSE
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| θ value | θ > 10 (rank : 24) | NC score | 0.113100 (rank : 21) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P97864, O08669 | Gene names | Casp7, Lice2, Mch3 | |||
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Domain Architecture |
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| Description | Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11]. | |||||
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CASP8_HUMAN
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| θ value | θ > 10 (rank : 25) | NC score | 0.104955 (rank : 23) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 62 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 | Gene names | CASP8, MCH5 | |||
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Domain Architecture |
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| Description | Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10]. | |||||
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CASP8_MOUSE
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| θ value | θ > 10 (rank : 26) | NC score | 0.102279 (rank : 24) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 57 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O89110, O35669 | Gene names | Casp8 | |||
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Domain Architecture |
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| Description | Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10]. | |||||
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CASP9_HUMAN
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| θ value | θ > 10 (rank : 27) | NC score | 0.158569 (rank : 14) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 33 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 | Gene names | CASP9, MCH6 | |||
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Domain Architecture |
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| Description | Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10]. | |||||
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CASPA_HUMAN
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| θ value | θ > 10 (rank : 28) | NC score | 0.140770 (rank : 15) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 53 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 | Gene names | CASP10, MCH4 | |||
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Domain Architecture |
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| Description | Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12]. | |||||
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CASPC_MOUSE
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| θ value | θ > 10 (rank : 29) | NC score | 0.313520 (rank : 5) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O08736, Q3TT82 | Gene names | Casp12 | |||
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Domain Architecture |
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| Description | Caspase-12 precursor (EC 3.4.22.-) (CASP-12). | |||||
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CASPE_HUMAN
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| θ value | θ > 10 (rank : 30) | NC score | 0.158967 (rank : 13) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 26 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P31944, O95823, Q3SYC9 | Gene names | CASP14 | |||
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Domain Architecture |
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| Description | Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2]. | |||||
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CASPE_MOUSE
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| θ value | θ > 10 (rank : 31) | NC score | 0.159463 (rank : 12) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 23 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O89094 | Gene names | Casp14 | |||
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Domain Architecture |
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| Description | Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2]. | |||||
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CFLAR_HUMAN
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| θ value | θ > 10 (rank : 32) | NC score | 0.067311 (rank : 27) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 47 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 | Gene names | CFLAR, CASH, CLARP, MRIT | |||
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Domain Architecture |
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| Description | CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]. | |||||
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CFLAR_MOUSE
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| θ value | θ > 10 (rank : 33) | NC score | 0.068380 (rank : 25) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 32 | Shared Neighborhood Hits | 2 | |
| SwissProt Accessions | O35732, O35707, O35733 | Gene names | Cflar, Cash | |||
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Domain Architecture |
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| Description | CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]. | |||||
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ICBR_HUMAN
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| NC score | 0.999962 (rank : 1) | θ value | 2.85459e-46 (rank : 1) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 11 | Shared Neighborhood Hits | 11 | |
| SwissProt Accessions | P57730 | Gene names | ICEBERG | |||
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Domain Architecture |
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| Description | Caspase-1 inhibitor Iceberg. | |||||
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CASP1_HUMAN
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| NC score | 0.507057 (rank : 2) | θ value | 3.51386e-20 (rank : 2) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 41 | Shared Neighborhood Hits | 9 | |
| SwissProt Accessions | P29466, Q9UCN3 | Gene names | CASP1, IL1BC, IL1BCE | |||
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Domain Architecture |
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| Description | Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit]. | |||||
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CASP1_MOUSE
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| NC score | 0.495282 (rank : 3) | θ value | 2.7842e-17 (rank : 3) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 38 | Shared Neighborhood Hits | 10 | |
| SwissProt Accessions | P29452 | Gene names | Casp1, Il1bc | |||
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Domain Architecture |
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| Description | Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit]. | |||||
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CASP4_HUMAN
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| NC score | 0.328938 (rank : 4) | θ value | 3.0926 (rank : 9) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 23 | Shared Neighborhood Hits | 4 | |
| SwissProt Accessions | P49662 | Gene names | CASP4, ICH2 | |||
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Domain Architecture |
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| Description | Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2]. | |||||
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CASPC_MOUSE
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| NC score | 0.313520 (rank : 5) | θ value | θ > 10 (rank : 29) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O08736, Q3TT82 | Gene names | Casp12 | |||
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Domain Architecture |
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| Description | Caspase-12 precursor (EC 3.4.22.-) (CASP-12). | |||||
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CASP5_HUMAN
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| NC score | 0.306669 (rank : 6) | θ value | θ > 10 (rank : 20) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 28 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P51878 | Gene names | CASP5, ICH3 | |||
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Domain Architecture |
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| Description | Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10]. | |||||
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CASP4_MOUSE
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| NC score | 0.303031 (rank : 7) | θ value | θ > 10 (rank : 19) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 28 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P70343, O08735 | Gene names | Casp4, Casp11, Caspl, Ich3 | |||
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Domain Architecture |
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| Description | Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20]. | |||||
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CARD6_HUMAN
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| NC score | 0.209998 (rank : 8) | θ value | 0.00509761 (rank : 4) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 145 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q9BX69 | Gene names | CARD6 | |||
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Domain Architecture |
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| Description | Caspase recruitment domain-containing protein 6. | |||||
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CASP2_MOUSE
|
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| NC score | 0.170980 (rank : 9) | θ value | θ > 10 (rank : 16) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 34 | Shared Neighborhood Hits | 4 | |
| SwissProt Accessions | P29594, O08737, Q3TCM0, Q8C9H7, Q8K241 | Gene names | Casp2, Ich1, Nedd-2, Nedd2 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]. | |||||
|
CARD8_HUMAN
|
||||||
| NC score | 0.167277 (rank : 10) | θ value | 0.813845 (rank : 7) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 22 | Shared Neighborhood Hits | 6 | |
| SwissProt Accessions | Q9Y2G2, Q6PGP8, Q96P82 | Gene names | CARD8, KIAA0955, NDPP1 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN). | |||||
|
CASP2_HUMAN
|
||||||
| NC score | 0.166832 (rank : 11) | θ value | θ > 10 (rank : 15) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 31 | Shared Neighborhood Hits | 4 | |
| SwissProt Accessions | P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9 | Gene names | CASP2, ICH1 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]. | |||||
|
CASPE_MOUSE
|
||||||
| NC score | 0.159463 (rank : 12) | θ value | θ > 10 (rank : 31) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 23 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O89094 | Gene names | Casp14 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-14 precursor (EC 3.4.22.-) (CASP-14) (Mini-ICE) (MICE) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2]. | |||||
|
CASPE_HUMAN
|
||||||
| NC score | 0.158967 (rank : 13) | θ value | θ > 10 (rank : 30) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 26 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P31944, O95823, Q3SYC9 | Gene names | CASP14 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-14 precursor (EC 3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14 subunit 2]. | |||||
|
CASP9_HUMAN
|
||||||
| NC score | 0.158569 (rank : 14) | θ value | θ > 10 (rank : 27) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 33 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P55211, O95348, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8 | Gene names | CASP9, MCH6 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-9 precursor (EC 3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease Mch-6) (Apoptotic protease- activating factor 3) (APAF-3) [Contains: Caspase-9 subunit p35; Caspase-9 subunit p10]. | |||||
|
CASPA_HUMAN
|
||||||
| NC score | 0.140770 (rank : 15) | θ value | θ > 10 (rank : 28) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 53 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | Q92851, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7 | Gene names | CASP10, MCH4 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-10 precursor (EC 3.4.22.-) (CASP-10) (ICE-like apoptotic protease 4) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit p12]. | |||||
|
CASP3_HUMAN
|
||||||
| NC score | 0.132209 (rank : 16) | θ value | θ > 10 (rank : 17) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 27 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P42574, Q96AN1, Q96KP2 | Gene names | CASP3, CPP32 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]. | |||||
|
CASP3_MOUSE
|
||||||
| NC score | 0.122761 (rank : 17) | θ value | θ > 10 (rank : 18) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 23 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P70677, O08668, Q8CHV5, Q9QWI4 | Gene names | Casp3, Cpp32 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]. | |||||
|
CASP6_HUMAN
|
||||||
| NC score | 0.120741 (rank : 18) | θ value | θ > 10 (rank : 21) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P55212, Q9BQE7 | Gene names | CASP6, MCH2 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11]. | |||||
|
CASP6_MOUSE
|
||||||
| NC score | 0.117149 (rank : 19) | θ value | θ > 10 (rank : 22) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O08738 | Gene names | Casp6 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-6 precursor (EC 3.4.22.-) (CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6 subunit p18; Caspase-6 subunit p11]. | |||||
|
CAR12_HUMAN
|
||||||
| NC score | 0.113633 (rank : 20) | θ value | 0.163984 (rank : 6) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 132 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q9NPP4, Q96J81, Q96J82, Q96J83 | Gene names | CARD12, CLAN, CLAN1 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein). | |||||
|
CASP7_MOUSE
|
||||||
| NC score | 0.113100 (rank : 21) | θ value | θ > 10 (rank : 24) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 24 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P97864, O08669 | Gene names | Casp7, Lice2, Mch3 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (LICE2 cysteine protease) (Apoptotic protease Mch-3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11]. | |||||
|
CASP7_HUMAN
|
||||||
| NC score | 0.107106 (rank : 22) | θ value | θ > 10 (rank : 23) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 26 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | P55210, Q13364, Q96BA0 | Gene names | CASP7, MCH3 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-7 precursor (EC 3.4.22.-) (CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11]. | |||||
|
CASP8_HUMAN
|
||||||
| NC score | 0.104955 (rank : 23) | θ value | θ > 10 (rank : 25) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 62 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | Q14790, O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81 | Gene names | CASP8, MCH5 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10]. | |||||
|
CASP8_MOUSE
|
||||||
| NC score | 0.102279 (rank : 24) | θ value | θ > 10 (rank : 26) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 57 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O89110, O35669 | Gene names | Casp8 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase-8 precursor (EC 3.4.22.-) (CASP-8) [Contains: Caspase-8 subunit p18; Caspase-8 subunit p10]. | |||||
|
CFLAR_MOUSE
|
||||||
| NC score | 0.068380 (rank : 25) | θ value | θ > 10 (rank : 33) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 32 | Shared Neighborhood Hits | 2 | |
| SwissProt Accessions | O35732, O35707, O35733 | Gene names | Cflar, Cash | |||
|
Domain Architecture |
|
|||||
| Description | CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]. | |||||
|
BIRC2_HUMAN
|
||||||
| NC score | 0.067642 (rank : 26) | θ value | θ > 10 (rank : 12) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 142 | Shared Neighborhood Hits | 6 | |
| SwissProt Accessions | Q13490, Q16516, Q4TTG0 | Gene names | BIRC2, API1, IAP2, MIHB | |||
|
Domain Architecture |
|
|||||
| Description | Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B). | |||||
|
CFLAR_HUMAN
|
||||||
| NC score | 0.067311 (rank : 27) | θ value | θ > 10 (rank : 32) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 47 | Shared Neighborhood Hits | 3 | |
| SwissProt Accessions | O15519, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q96TE4, Q9UEW1 | Gene names | CFLAR, CASH, CLARP, MRIT | |||
|
Domain Architecture |
|
|||||
| Description | CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]. | |||||
|
BIRC3_MOUSE
|
||||||
| NC score | 0.066423 (rank : 28) | θ value | 0.0330416 (rank : 5) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 113 | Shared Neighborhood Hits | 2 | |
| SwissProt Accessions | O08863 | Gene names | Birc3, Birc2, Iap1 | |||
|
Domain Architecture |
|
|||||
| Description | Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1). | |||||
|
BIRC2_MOUSE
|
||||||
| NC score | 0.062826 (rank : 29) | θ value | θ > 10 (rank : 13) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 137 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q62210, O08864 | Gene names | Birc2, Birc3, Iap2 | |||
|
Domain Architecture |
|
|||||
| Description | Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2). | |||||
|
BIRC3_HUMAN
|
||||||
| NC score | 0.061929 (rank : 30) | θ value | θ > 10 (rank : 14) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 133 | Shared Neighborhood Hits | 6 | |
| SwissProt Accessions | Q13489, Q16628, Q9HC27, Q9UP46 | Gene names | BIRC3, API2, IAP1, MIHC | |||
|
Domain Architecture |
|
|||||
| Description | Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2). | |||||
|
CAR15_MOUSE
|
||||||
| NC score | 0.057373 (rank : 31) | θ value | 3.0926 (rank : 8) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 93 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q8K3Z0 | Gene names | Card15, Nod2 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase recruitment domain-containing protein 15 (Protein Nod2). | |||||
|
CAR15_HUMAN
|
||||||
| NC score | 0.055235 (rank : 32) | θ value | 8.99809 (rank : 11) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 77 | Shared Neighborhood Hits | 8 | |
| SwissProt Accessions | Q9HC29, Q96RH5, Q96RH6, Q96RH8 | Gene names | CARD15, IBD1, NOD2 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1). | |||||
|
CARD4_HUMAN
|
||||||
| NC score | 0.047559 (rank : 33) | θ value | 6.88961 (rank : 10) | |||
| Query Neighborhood Hits | 11 | Target Neighborhood Hits | 102 | Shared Neighborhood Hits | 7 | |
| SwissProt Accessions | Q9Y239, Q8IWF5 | Gene names | CARD4, NOD1 | |||
|
Domain Architecture |
|
|||||
| Description | Caspase recruitment domain-containing protein 4 (Protein Nod1). | |||||
