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Network neighborhood for query Sequence : CARD8_HUMAN

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CARD8_HUMAN
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CARD8_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

NALP1_HUMAN
θ value	4.21644e-82 (rank : 2)	NC score	0.393267 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

CAR12_HUMAN
θ value	0.00102713 (rank : 3)	NC score	0.148531 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	132	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CASP1_HUMAN
θ value	0.00298849 (rank : 4)	NC score	0.127866 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

ASC_HUMAN
θ value	0.0330416 (rank : 5)	NC score	0.295040 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

CASP1_MOUSE
θ value	0.0736092 (rank : 6)	NC score	0.110151 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

BIRC2_MOUSE
θ value	0.279714 (rank : 7)	NC score	0.057499 (rank : 48)
Query Neighborhood Hits	22	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

CARD6_HUMAN
θ value	0.279714 (rank : 8)	NC score	0.087542 (rank : 26)
Query Neighborhood Hits	22	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

ICBR_HUMAN
θ value	0.813845 (rank : 9)	NC score	0.167277 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

KIF4A_HUMAN
θ value	0.813845 (rank : 10)	NC score	0.018650 (rank : 52)
Query Neighborhood Hits	22	Target Neighborhood Hits	1159	Shared Neighborhood Hits	7
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

CASP2_HUMAN
θ value	1.06291 (rank : 11)	NC score	0.076359 (rank : 32)
Query Neighborhood Hits	22	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.076567 (rank : 31)
Query Neighborhood Hits	22	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

UACA_MOUSE
θ value	1.06291 (rank : 13)	NC score	0.014414 (rank : 55)
Query Neighborhood Hits	22	Target Neighborhood Hits	1620	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

BIRC3_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.048338 (rank : 49)
Query Neighborhood Hits	22	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

CEBPZ_MOUSE
θ value	4.03905 (rank : 15)	NC score	0.028177 (rank : 50)
Query Neighborhood Hits	22	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	P53569, Q3TXW5, Q3TYA8, Q3UWQ7	Gene names	Cebpz, Cbf2, Cebpa-rs1
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

CP250_HUMAN
θ value	4.03905 (rank : 16)	NC score	0.011117 (rank : 57)
Query Neighborhood Hits	22	Target Neighborhood Hits	1805	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

FA21C_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.025782 (rank : 51)
Query Neighborhood Hits	22	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

GOGA3_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.011214 (rank : 56)
Query Neighborhood Hits	22	Target Neighborhood Hits	1317	Shared Neighborhood Hits	7
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

KIF4A_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.015780 (rank : 54)
Query Neighborhood Hits	22	Target Neighborhood Hits	1033	Shared Neighborhood Hits	7
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

SPAG5_MOUSE
θ value	6.88961 (rank : 20)	NC score	0.016932 (rank : 53)
Query Neighborhood Hits	22	Target Neighborhood Hits	612	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

ZNF24_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.000965 (rank : 59)
Query Neighborhood Hits	22	Target Neighborhood Hits	717	Shared Neighborhood Hits	4
SwissProt Accessions	Q91VN1, Q9WUQ0	Gene names	Znf24, Zfp191
Domain Architecture
Description	Zinc finger protein 24 (Zinc finger protein 191) (Zfp-191) (Zinc finger protein ZF-12).

ASB3_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.006887 (rank : 58)
Query Neighborhood Hits	22	Target Neighborhood Hits	316	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASC_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.223388 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

BIR1A_MOUSE
θ value	θ > 10 (rank : 24)	NC score	0.059096 (rank : 45)
Query Neighborhood Hits	22	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1B_MOUSE
θ value	θ > 10 (rank : 25)	NC score	0.058767 (rank : 47)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
θ value	θ > 10 (rank : 26)	NC score	0.062364 (rank : 40)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.059285 (rank : 44)
Query Neighborhood Hits	22	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.058911 (rank : 46)
Query Neighborhood Hits	22	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIRC1_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.062626 (rank : 38)
Query Neighborhood Hits	22	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

C2TA_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.067123 (rank : 34)
Query Neighborhood Hits	22	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.064189 (rank : 36)
Query Neighborhood Hits	22	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CAR15_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.083740 (rank : 28)
Query Neighborhood Hits	22	Target Neighborhood Hits	77	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.082031 (rank : 29)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CARD4_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.067161 (rank : 33)
Query Neighborhood Hits	22	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.066817 (rank : 35)
Query Neighborhood Hits	22	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CASP4_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.062570 (rank : 39)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

CASP4_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.061309 (rank : 42)
Query Neighborhood Hits	22	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP5_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.060570 (rank : 43)
Query Neighborhood Hits	22	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

CASPC_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.061776 (rank : 41)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

CF154_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.080427 (rank : 30)
Query Neighborhood Hits	22	Target Neighborhood Hits	36	Shared Neighborhood Hits	1
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

CIAS1_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.125653 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.123527 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

LRC31_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.085966 (rank : 27)
Query Neighborhood Hits	22	Target Neighborhood Hits	139	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

NAL10_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.131657 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.125997 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NAL11_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.112794 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NAL12_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.124460 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NAL13_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.120759 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NAL14_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.119970 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.116150 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP4_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.115685 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP5_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.114955 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP5_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.107540 (rank : 23)
Query Neighborhood Hits	22	Target Neighborhood Hits	560	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP6_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.125155 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.126744 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP7_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.117084 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

PS1C2_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.062658 (rank : 37)
Query Neighborhood Hits	22	Target Neighborhood Hits	66	Shared Neighborhood Hits	1
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

RINI_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.107178 (rank : 24)
Query Neighborhood Hits	22	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.104019 (rank : 25)
Query Neighborhood Hits	22	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

Hits sorted by NC score

CARD8_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

NALP1_HUMAN
NC score	0.393267 (rank : 2)	θ value	4.21644e-82 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

ASC_HUMAN
NC score	0.295040 (rank : 3)	θ value	0.0330416 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

ASC_MOUSE
NC score	0.223388 (rank : 4)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

ICBR_HUMAN
NC score	0.167277 (rank : 5)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

CAR12_HUMAN
NC score	0.148531 (rank : 6)	θ value	0.00102713 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	132	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

NAL10_HUMAN
NC score	0.131657 (rank : 7)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	22	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

CASP1_HUMAN
NC score	0.127866 (rank : 8)	θ value	0.00298849 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

NALP6_MOUSE
NC score	0.126744 (rank : 9)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	22	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NAL10_MOUSE
NC score	0.125997 (rank : 10)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	22	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CIAS1_HUMAN
NC score	0.125653 (rank : 11)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	22	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NALP6_HUMAN
NC score	0.125155 (rank : 12)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	22	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NAL12_HUMAN
NC score	0.124460 (rank : 13)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	22	Target Neighborhood Hits	96	Shared Neighborhood Hits	3
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_MOUSE
NC score	0.123527 (rank : 14)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	22	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL13_HUMAN
NC score	0.120759 (rank : 15)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NAL14_HUMAN
NC score	0.119970 (rank : 16)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	22	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP7_HUMAN
NC score	0.117084 (rank : 17)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	22	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP2_HUMAN
NC score	0.116150 (rank : 18)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	22	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP4_HUMAN
NC score	0.115685 (rank : 19)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	22	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP5_HUMAN
NC score	0.114955 (rank : 20)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	22	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL11_HUMAN
NC score	0.112794 (rank : 21)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	22	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

CASP1_MOUSE
NC score	0.110151 (rank : 22)	θ value	0.0736092 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

NALP5_MOUSE
NC score	0.107540 (rank : 23)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	22	Target Neighborhood Hits	560	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RINI_HUMAN
NC score	0.107178 (rank : 24)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	22	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
NC score	0.104019 (rank : 25)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	22	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CARD6_HUMAN
NC score	0.087542 (rank : 26)	θ value	0.279714 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

LRC31_HUMAN
NC score	0.085966 (rank : 27)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	22	Target Neighborhood Hits	139	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

CAR15_HUMAN
NC score	0.083740 (rank : 28)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	22	Target Neighborhood Hits	77	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
NC score	0.082031 (rank : 29)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CF154_HUMAN
NC score	0.080427 (rank : 30)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	22	Target Neighborhood Hits	36	Shared Neighborhood Hits	1
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

CASP2_MOUSE
NC score	0.076567 (rank : 31)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_HUMAN
NC score	0.076359 (rank : 32)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CARD4_HUMAN
NC score	0.067161 (rank : 33)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	22	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

C2TA_HUMAN
NC score	0.067123 (rank : 34)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	22	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

CARD4_MOUSE
NC score	0.066817 (rank : 35)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	22	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_MOUSE
NC score	0.064189 (rank : 36)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	22	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

PS1C2_HUMAN
NC score	0.062658 (rank : 37)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	22	Target Neighborhood Hits	66	Shared Neighborhood Hits	1
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

BIRC1_HUMAN
NC score	0.062626 (rank : 38)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	22	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

CASP4_HUMAN
NC score	0.062570 (rank : 39)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	22	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P49662	Gene names	CASP4, ICH2
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II) [Contains: Caspase-4 subunit 1; Caspase-4 subunit 2].

BIR1E_MOUSE
NC score	0.062364 (rank : 40)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

CASPC_MOUSE
NC score	0.061776 (rank : 41)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	22	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	O08736, Q3TT82	Gene names	Casp12
Domain Architecture
Description	Caspase-12 precursor (EC 3.4.22.-) (CASP-12).

CASP4_MOUSE
NC score	0.061309 (rank : 42)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	22	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P70343, O08735	Gene names	Casp4, Casp11, Caspl, Ich3
Domain Architecture
Description	Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (Caspase-11) (ICH-3 protease) [Contains: Caspase-4 subunit p10; Caspase-4 subunit p20].

CASP5_HUMAN
NC score	0.060570 (rank : 43)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	22	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P51878	Gene names	CASP5, ICH3
Domain Architecture
Description	Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III) [Contains: Caspase-5 subunit p20; Caspase-5 subunit p10].

BIR1F_MOUSE
NC score	0.059285 (rank : 44)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	22	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1A_MOUSE
NC score	0.059096 (rank : 45)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	22	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1G_MOUSE
NC score	0.058911 (rank : 46)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	22	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.058767 (rank : 47)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	22	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIRC2_MOUSE
NC score	0.057499 (rank : 48)	θ value	0.279714 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
NC score	0.048338 (rank : 49)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

CEBPZ_MOUSE
NC score	0.028177 (rank : 50)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	P53569, Q3TXW5, Q3TYA8, Q3UWQ7	Gene names	Cebpz, Cbf2, Cebpa-rs1
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

FA21C_HUMAN
NC score	0.025782 (rank : 51)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

KIF4A_HUMAN
NC score	0.018650 (rank : 52)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	1159	Shared Neighborhood Hits	7
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

SPAG5_MOUSE
NC score	0.016932 (rank : 53)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	612	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

KIF4A_MOUSE
NC score	0.015780 (rank : 54)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	1033	Shared Neighborhood Hits	7
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

UACA_MOUSE
NC score	0.014414 (rank : 55)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	1620	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

GOGA3_HUMAN
NC score	0.011214 (rank : 56)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	1317	Shared Neighborhood Hits	7
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

CP250_HUMAN
NC score	0.011117 (rank : 57)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	1805	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

ASB3_MOUSE
NC score	0.006887 (rank : 58)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	316	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ZNF24_MOUSE
NC score	0.000965 (rank : 59)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	717	Shared Neighborhood Hits	4
SwissProt Accessions	Q91VN1, Q9WUQ0	Gene names	Znf24, Zfp191
Domain Architecture
Description	Zinc finger protein 24 (Zinc finger protein 191) (Zfp-191) (Zinc finger protein ZF-12).