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Network neighborhood for query Sequence : CARD4_MOUSE

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CARD4_MOUSE
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CARD4_HUMAN
θ value	0 (rank : 1)	NC score	0.986679 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	102	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CAR15_HUMAN
θ value	6.44497e-115 (rank : 3)	NC score	0.924702 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
θ value	1.8752e-114 (rank : 4)	NC score	0.926779 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

NAL12_HUMAN
θ value	5.97985e-28 (rank : 5)	NC score	0.729326 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	96	Shared Neighborhood Hits	44
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_HUMAN
θ value	6.61148e-27 (rank : 6)	NC score	0.719134 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NAL14_HUMAN
θ value	5.59698e-26 (rank : 7)	NC score	0.715031 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP2_HUMAN
θ value	5.59698e-26 (rank : 8)	NC score	0.714711 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP5_MOUSE
θ value	1.80048e-24 (rank : 9)	NC score	0.660486 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	560	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP7_HUMAN
θ value	2.20094e-22 (rank : 10)	NC score	0.708218 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	65	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

CIAS1_MOUSE
θ value	1.42661e-21 (rank : 11)	NC score	0.714687 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	67	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NALP5_HUMAN
θ value	2.06002e-20 (rank : 12)	NC score	0.695862 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	41
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

C2TA_MOUSE
θ value	3.28887e-18 (rank : 13)	NC score	0.661870 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

NALP4_HUMAN
θ value	4.29542e-18 (rank : 14)	NC score	0.709147 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	81	Shared Neighborhood Hits	46
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

RINI_HUMAN
θ value	1.52774e-15 (rank : 15)	NC score	0.699647 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	78	Shared Neighborhood Hits	41
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

LRC34_HUMAN
θ value	1.99529e-15 (rank : 16)	NC score	0.667300 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	67	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

C2TA_HUMAN
θ value	4.44505e-15 (rank : 17)	NC score	0.633172 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_MOUSE
θ value	9.90251e-15 (rank : 18)	NC score	0.638140 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

NAL13_HUMAN
θ value	9.90251e-15 (rank : 19)	NC score	0.694491 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP6_MOUSE
θ value	1.29331e-14 (rank : 20)	NC score	0.667781 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

RINI_MOUSE
θ value	4.91457e-14 (rank : 21)	NC score	0.689774 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

NALP1_HUMAN
θ value	2.69671e-12 (rank : 22)	NC score	0.653337 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	138	Shared Neighborhood Hits	38
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP6_HUMAN
θ value	1.02475e-11 (rank : 23)	NC score	0.654990 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	52	Shared Neighborhood Hits	34
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NAL10_MOUSE
θ value	3.29651e-10 (rank : 24)	NC score	0.632423 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	46	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

LRC45_MOUSE
θ value	1.25267e-09 (rank : 25)	NC score	0.237327 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

NAL10_HUMAN
θ value	4.76016e-09 (rank : 26)	NC score	0.637299 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	55	Shared Neighborhood Hits	29
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

TMOD2_MOUSE
θ value	1.38499e-08 (rank : 27)	NC score	0.308097 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD2_HUMAN
θ value	5.26297e-08 (rank : 28)	NC score	0.321730 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

LRC45_HUMAN
θ value	1.53129e-07 (rank : 29)	NC score	0.223497 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	933	Shared Neighborhood Hits	35
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

TMOD3_HUMAN
θ value	1.53129e-07 (rank : 30)	NC score	0.306520 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYL9, Q9NT43, Q9NZR0	Gene names	TMOD3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

CAR12_HUMAN
θ value	3.41135e-07 (rank : 31)	NC score	0.332732 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	132	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

TMOD3_MOUSE
θ value	1.69304e-06 (rank : 32)	NC score	0.307262 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

TMOD1_MOUSE
θ value	6.43352e-06 (rank : 33)	NC score	0.309856 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	P49813, Q9ERR9	Gene names	Tmod1, Tmod
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

RGP1_HUMAN
θ value	1.43324e-05 (rank : 34)	NC score	0.421028 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

TMOD1_HUMAN
θ value	4.1701e-05 (rank : 35)	NC score	0.306708 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	P28289, Q9BUF1	Gene names	TMOD1, TMOD
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

RGP1_MOUSE
θ value	7.1131e-05 (rank : 36)	NC score	0.389399 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

LMD1_HUMAN
θ value	0.000158464 (rank : 37)	NC score	0.288396 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	P29536	Gene names	LMOD1
Domain Architecture
Description	Leiomodin-1 (Leiomodin, muscle form) (64 kDa autoantigen D1) (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (Thyroid-associated ophthalmopathy autoantigen) (Smooth muscle leiomodin) (SM-Lmod).

TMOD4_MOUSE
θ value	0.000158464 (rank : 38)	NC score	0.290822 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLH8	Gene names	Tmod4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

TMOD4_HUMAN
θ value	0.00020696 (rank : 39)	NC score	0.293442 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	37	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZQ9, Q8WVL3, Q9UKH2	Gene names	TMOD4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

CF154_HUMAN
θ value	0.000270298 (rank : 40)	NC score	0.507500 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

NAL11_HUMAN
θ value	0.000602161 (rank : 41)	NC score	0.629426 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	66	Shared Neighborhood Hits	37
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

PGS2_MOUSE
θ value	0.0113563 (rank : 42)	NC score	0.031799 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	285	Shared Neighborhood Hits	19
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

RIPK2_HUMAN
θ value	0.0113563 (rank : 43)	NC score	0.024827 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	774	Shared Neighborhood Hits	7
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	0.0193708 (rank : 44)	NC score	0.021822 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	776	Shared Neighborhood Hits	8
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

NOL3_MOUSE
θ value	0.0736092 (rank : 45)	NC score	0.119235 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D1X0	Gene names	Nol3
Domain Architecture
Description	Nucleolar protein 3.

BIRC1_HUMAN
θ value	0.0961366 (rank : 46)	NC score	0.184730 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

LAP2_HUMAN
θ value	0.125558 (rank : 47)	NC score	0.028994 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	499	Shared Neighborhood Hits	20
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LRC14_HUMAN
θ value	0.163984 (rank : 48)	NC score	0.080885 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

LRC49_MOUSE
θ value	0.163984 (rank : 49)	NC score	0.047318 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	230	Shared Neighborhood Hits	18
SwissProt Accessions	Q91YK0, Q8C3S4, Q8C7T7	Gene names	Lrrc49
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79).

NOL3_HUMAN
θ value	0.21417 (rank : 50)	NC score	0.129481 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	7
SwissProt Accessions	O60936, O60937	Gene names	NOL3, ARC, NOP
Domain Architecture
Description	Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30).

BIRC2_MOUSE
θ value	0.279714 (rank : 51)	NC score	0.060231 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	137	Shared Neighborhood Hits	15
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIR1B_MOUSE
θ value	0.365318 (rank : 52)	NC score	0.162787 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

CASP1_MOUSE
θ value	0.365318 (rank : 53)	NC score	0.032496 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

BIR1G_MOUSE
θ value	0.47712 (rank : 54)	NC score	0.160902 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

LRC40_MOUSE
θ value	0.47712 (rank : 55)	NC score	0.036966 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	311	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CRC8, Q78WQ9, Q8BS83	Gene names	Lrrc40
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 40.

BIR1F_MOUSE
θ value	0.62314 (rank : 56)	NC score	0.166460 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

LRC39_MOUSE
θ value	0.813845 (rank : 57)	NC score	0.035586 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	269	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BGI7	Gene names	Lrrc39
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 39.

ABCAA_HUMAN
θ value	1.06291 (rank : 58)	NC score	0.012417 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWZ4, Q6PIQ6, Q7Z2I9, Q7Z7P7, Q86TD2	Gene names	ABCA10
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 10.

LRTM3_HUMAN
θ value	1.06291 (rank : 59)	NC score	0.024317 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	276	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

PON3_MOUSE
θ value	1.06291 (rank : 60)	NC score	0.027946 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q62087, Q8C2I7	Gene names	Pon3
Domain Architecture
Description	Serum paraoxonase/lactonase 3 (EC 3.1.1.-).

SYNE2_HUMAN
θ value	1.06291 (rank : 61)	NC score	0.007622 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	1323	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

LRTM3_MOUSE
θ value	1.81305 (rank : 62)	NC score	0.023482 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

PHLPP_HUMAN
θ value	1.81305 (rank : 63)	NC score	0.036667 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	604	Shared Neighborhood Hits	26
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PP1R7_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.038830 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	265	Shared Neighborhood Hits	18
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

ROBO3_HUMAN
θ value	1.81305 (rank : 65)	NC score	0.002638 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	570	Shared Neighborhood Hits	3
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ABCA8_HUMAN
θ value	2.36792 (rank : 66)	NC score	0.011746 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	O94911, Q86WW0	Gene names	ABCA8, KIAA0822
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 8.

BIRC2_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.055276 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

CD180_MOUSE
θ value	2.36792 (rank : 68)	NC score	0.016641 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

RSU1_HUMAN
θ value	2.36792 (rank : 69)	NC score	0.020087 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	250	Shared Neighborhood Hits	15
SwissProt Accessions	Q15404	Gene names	RSU1, RSP1
Domain Architecture
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

BIR1E_MOUSE
θ value	3.0926 (rank : 70)	NC score	0.159097 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

C11B2_HUMAN
θ value	3.0926 (rank : 71)	NC score	0.005373 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P19099, Q16726	Gene names	CYP11B2
Domain Architecture
Description	Cytochrome P450 11B2, mitochondrial precursor (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P-450Aldo) (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (Steroid 18-hydroxylase) (P-450C18).

PGS2_HUMAN
θ value	3.0926 (rank : 72)	NC score	0.019753 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	271	Shared Neighborhood Hits	17
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

PP1R7_MOUSE
θ value	3.0926 (rank : 73)	NC score	0.041379 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	256	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UM45, Q9CV31, Q9Z105	Gene names	Ppp1r7, Sds22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

TTC3_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.010954 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	664	Shared Neighborhood Hits	5
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

BIR1A_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.162669 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

FBXL7_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.030910 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UJT9, O94926	Gene names	FBXL7, FBL6, FBL7, KIAA0840
Domain Architecture
Description	F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7).

FXL16_HUMAN
θ value	5.27518 (rank : 77)	NC score	0.042245 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N461, Q2MHR2, Q96S14, Q9UJI0	Gene names	FBXL16, C16orf22, FBL16
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16).

RSU1_MOUSE
θ value	5.27518 (rank : 78)	NC score	0.022895 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	Q01730	Gene names	Rsu1, Rsp1
Domain Architecture	No domain graphic available
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

IPO4_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.008639 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

LPIN1_MOUSE
θ value	6.88961 (rank : 80)	NC score	0.006308 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q91ZP3, Q9CQI2, Q9JLG6	Gene names	Lpin1, Fld
Domain Architecture
Description	Lipin-1 (Fatty liver dystrophy protein).

LRIG1_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.010342 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	627	Shared Neighborhood Hits	19
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

ABCA9_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.009529 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

ABCD4_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.010154 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	O14678	Gene names	ABCD4, PXMP1L
Domain Architecture
Description	ATP-binding cassette sub-family D member 4 (Peroxisomal membrane protein 69) (PMP69) (Peroxisomal membrane protein 1-like) (PXMP1-L) (P70R).

KIF6_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.001563 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMV9, Q2MDE3, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4	Gene names	KIF6, C6orf102
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF6.

PHLPP_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.032112 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	394	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

ASC_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.125777 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

ASC_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.141336 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

CARD8_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.066817 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

LRC31_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.385807 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	139	Shared Neighborhood Hits	41
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC41_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.060242 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

LRC41_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.058611 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	37	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K1C9, Q91VX4	Gene names	Lrrc41, Muf1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

MEFV_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.076378 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

Hits sorted by NC score

CARD4_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CARD4_HUMAN
NC score	0.986679 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	102	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CAR15_MOUSE
NC score	0.926779 (rank : 3)	θ value	1.8752e-114 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.924702 (rank : 4)	θ value	6.44497e-115 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

NAL12_HUMAN
NC score	0.729326 (rank : 5)	θ value	5.97985e-28 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	96	Shared Neighborhood Hits	44
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_HUMAN
NC score	0.719134 (rank : 6)	θ value	6.61148e-27 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NAL14_HUMAN
NC score	0.715031 (rank : 7)	θ value	5.59698e-26 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP2_HUMAN
NC score	0.714711 (rank : 8)	θ value	5.59698e-26 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

CIAS1_MOUSE
NC score	0.714687 (rank : 9)	θ value	1.42661e-21 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	67	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NALP4_HUMAN
NC score	0.709147 (rank : 10)	θ value	4.29542e-18 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	81	Shared Neighborhood Hits	46
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP7_HUMAN
NC score	0.708218 (rank : 11)	θ value	2.20094e-22 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	65	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

RINI_HUMAN
NC score	0.699647 (rank : 12)	θ value	1.52774e-15 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	78	Shared Neighborhood Hits	41
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

NALP5_HUMAN
NC score	0.695862 (rank : 13)	θ value	2.06002e-20 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	41
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL13_HUMAN
NC score	0.694491 (rank : 14)	θ value	9.90251e-15 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

RINI_MOUSE
NC score	0.689774 (rank : 15)	θ value	4.91457e-14 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

NALP6_MOUSE
NC score	0.667781 (rank : 16)	θ value	1.29331e-14 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

LRC34_HUMAN
NC score	0.667300 (rank : 17)	θ value	1.99529e-15 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	67	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

C2TA_MOUSE
NC score	0.661870 (rank : 18)	θ value	3.28887e-18 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

NALP5_MOUSE
NC score	0.660486 (rank : 19)	θ value	1.80048e-24 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	560	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP6_HUMAN
NC score	0.654990 (rank : 20)	θ value	1.02475e-11 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	52	Shared Neighborhood Hits	34
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP1_HUMAN
NC score	0.653337 (rank : 21)	θ value	2.69671e-12 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	138	Shared Neighborhood Hits	38
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

LRC34_MOUSE
NC score	0.638140 (rank : 22)	θ value	9.90251e-15 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

NAL10_HUMAN
NC score	0.637299 (rank : 23)	θ value	4.76016e-09 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	55	Shared Neighborhood Hits	29
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

C2TA_HUMAN
NC score	0.633172 (rank : 24)	θ value	4.44505e-15 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

NAL10_MOUSE
NC score	0.632423 (rank : 25)	θ value	3.29651e-10 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	46	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NAL11_HUMAN
NC score	0.629426 (rank : 26)	θ value	0.000602161 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	66	Shared Neighborhood Hits	37
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

CF154_HUMAN
NC score	0.507500 (rank : 27)	θ value	0.000270298 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

RGP1_HUMAN
NC score	0.421028 (rank : 28)	θ value	1.43324e-05 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.389399 (rank : 29)	θ value	7.1131e-05 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

LRC31_HUMAN
NC score	0.385807 (rank : 30)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	139	Shared Neighborhood Hits	41
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

CAR12_HUMAN
NC score	0.332732 (rank : 31)	θ value	3.41135e-07 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	132	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

TMOD2_HUMAN
NC score	0.321730 (rank : 32)	θ value	5.26297e-08 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD1_MOUSE
NC score	0.309856 (rank : 33)	θ value	6.43352e-06 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	P49813, Q9ERR9	Gene names	Tmod1, Tmod
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

TMOD2_MOUSE
NC score	0.308097 (rank : 34)	θ value	1.38499e-08 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD3_MOUSE
NC score	0.307262 (rank : 35)	θ value	1.69304e-06 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	34	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

TMOD1_HUMAN
NC score	0.306708 (rank : 36)	θ value	4.1701e-05 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	19
SwissProt Accessions	P28289, Q9BUF1	Gene names	TMOD1, TMOD
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

TMOD3_HUMAN
NC score	0.306520 (rank : 37)	θ value	1.53129e-07 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYL9, Q9NT43, Q9NZR0	Gene names	TMOD3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

TMOD4_HUMAN
NC score	0.293442 (rank : 38)	θ value	0.00020696 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	37	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZQ9, Q8WVL3, Q9UKH2	Gene names	TMOD4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

TMOD4_MOUSE
NC score	0.290822 (rank : 39)	θ value	0.000158464 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLH8	Gene names	Tmod4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

LMD1_HUMAN
NC score	0.288396 (rank : 40)	θ value	0.000158464 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	P29536	Gene names	LMOD1
Domain Architecture
Description	Leiomodin-1 (Leiomodin, muscle form) (64 kDa autoantigen D1) (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (Thyroid-associated ophthalmopathy autoantigen) (Smooth muscle leiomodin) (SM-Lmod).

LRC45_MOUSE
NC score	0.237327 (rank : 41)	θ value	1.25267e-09 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
NC score	0.223497 (rank : 42)	θ value	1.53129e-07 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	933	Shared Neighborhood Hits	35
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

BIRC1_HUMAN
NC score	0.184730 (rank : 43)	θ value	0.0961366 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1F_MOUSE
NC score	0.166460 (rank : 44)	θ value	0.62314 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1B_MOUSE
NC score	0.162787 (rank : 45)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1A_MOUSE
NC score	0.162669 (rank : 46)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1G_MOUSE
NC score	0.160902 (rank : 47)	θ value	0.47712 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1E_MOUSE
NC score	0.159097 (rank : 48)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

ASC_MOUSE
NC score	0.141336 (rank : 49)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

NOL3_HUMAN
NC score	0.129481 (rank : 50)	θ value	0.21417 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	7
SwissProt Accessions	O60936, O60937	Gene names	NOL3, ARC, NOP
Domain Architecture
Description	Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30).

ASC_HUMAN
NC score	0.125777 (rank : 51)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

NOL3_MOUSE
NC score	0.119235 (rank : 52)	θ value	0.0736092 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D1X0	Gene names	Nol3
Domain Architecture
Description	Nucleolar protein 3.

LRC14_HUMAN
NC score	0.080885 (rank : 53)	θ value	0.163984 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

MEFV_MOUSE
NC score	0.076378 (rank : 54)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

CARD8_HUMAN
NC score	0.066817 (rank : 55)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

LRC41_HUMAN
NC score	0.060242 (rank : 56)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

BIRC2_MOUSE
NC score	0.060231 (rank : 57)	θ value	0.279714 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	137	Shared Neighborhood Hits	15
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

LRC41_MOUSE
NC score	0.058611 (rank : 58)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	37	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K1C9, Q91VX4	Gene names	Lrrc41, Muf1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

BIRC2_HUMAN
NC score	0.055276 (rank : 59)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

LRC49_MOUSE
NC score	0.047318 (rank : 60)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	230	Shared Neighborhood Hits	18
SwissProt Accessions	Q91YK0, Q8C3S4, Q8C7T7	Gene names	Lrrc49
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79).

FXL16_HUMAN
NC score	0.042245 (rank : 61)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N461, Q2MHR2, Q96S14, Q9UJI0	Gene names	FBXL16, C16orf22, FBL16
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16).

PP1R7_MOUSE
NC score	0.041379 (rank : 62)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	256	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UM45, Q9CV31, Q9Z105	Gene names	Ppp1r7, Sds22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

PP1R7_HUMAN
NC score	0.038830 (rank : 63)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	265	Shared Neighborhood Hits	18
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

LRC40_MOUSE
NC score	0.036966 (rank : 64)	θ value	0.47712 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	311	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CRC8, Q78WQ9, Q8BS83	Gene names	Lrrc40
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 40.

PHLPP_HUMAN
NC score	0.036667 (rank : 65)	θ value	1.81305 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	604	Shared Neighborhood Hits	26
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

LRC39_MOUSE
NC score	0.035586 (rank : 66)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	269	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BGI7	Gene names	Lrrc39
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 39.

CASP1_MOUSE
NC score	0.032496 (rank : 67)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

PHLPP_MOUSE
NC score	0.032112 (rank : 68)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	394	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PGS2_MOUSE
NC score	0.031799 (rank : 69)	θ value	0.0113563 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	285	Shared Neighborhood Hits	19
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

FBXL7_HUMAN
NC score	0.030910 (rank : 70)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	91	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UJT9, O94926	Gene names	FBXL7, FBL6, FBL7, KIAA0840
Domain Architecture
Description	F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7).

LAP2_HUMAN
NC score	0.028994 (rank : 71)	θ value	0.125558 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	499	Shared Neighborhood Hits	20
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PON3_MOUSE
NC score	0.027946 (rank : 72)	θ value	1.06291 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q62087, Q8C2I7	Gene names	Pon3
Domain Architecture
Description	Serum paraoxonase/lactonase 3 (EC 3.1.1.-).

RIPK2_HUMAN
NC score	0.024827 (rank : 73)	θ value	0.0113563 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	774	Shared Neighborhood Hits	7
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

LRTM3_HUMAN
NC score	0.024317 (rank : 74)	θ value	1.06291 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	276	Shared Neighborhood Hits	18
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

LRTM3_MOUSE
NC score	0.023482 (rank : 75)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

RSU1_MOUSE
NC score	0.022895 (rank : 76)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	Q01730	Gene names	Rsu1, Rsp1
Domain Architecture	No domain graphic available
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

RIPK2_MOUSE
NC score	0.021822 (rank : 77)	θ value	0.0193708 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	776	Shared Neighborhood Hits	8
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RSU1_HUMAN
NC score	0.020087 (rank : 78)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	250	Shared Neighborhood Hits	15
SwissProt Accessions	Q15404	Gene names	RSU1, RSP1
Domain Architecture
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

PGS2_HUMAN
NC score	0.019753 (rank : 79)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	271	Shared Neighborhood Hits	17
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

CD180_MOUSE
NC score	0.016641 (rank : 80)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

ABCAA_HUMAN
NC score	0.012417 (rank : 81)	θ value	1.06291 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWZ4, Q6PIQ6, Q7Z2I9, Q7Z7P7, Q86TD2	Gene names	ABCA10
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 10.

ABCA8_HUMAN
NC score	0.011746 (rank : 82)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	O94911, Q86WW0	Gene names	ABCA8, KIAA0822
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 8.

TTC3_HUMAN
NC score	0.010954 (rank : 83)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	664	Shared Neighborhood Hits	5
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

LRIG1_MOUSE
NC score	0.010342 (rank : 84)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	627	Shared Neighborhood Hits	19
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

ABCD4_HUMAN
NC score	0.010154 (rank : 85)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	O14678	Gene names	ABCD4, PXMP1L
Domain Architecture
Description	ATP-binding cassette sub-family D member 4 (Peroxisomal membrane protein 69) (PMP69) (Peroxisomal membrane protein 1-like) (PXMP1-L) (P70R).

ABCA9_HUMAN
NC score	0.009529 (rank : 86)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

IPO4_HUMAN
NC score	0.008639 (rank : 87)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

SYNE2_HUMAN
NC score	0.007622 (rank : 88)	θ value	1.06291 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	1323	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

LPIN1_MOUSE
NC score	0.006308 (rank : 89)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q91ZP3, Q9CQI2, Q9JLG6	Gene names	Lpin1, Fld
Domain Architecture
Description	Lipin-1 (Fatty liver dystrophy protein).

C11B2_HUMAN
NC score	0.005373 (rank : 90)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P19099, Q16726	Gene names	CYP11B2
Domain Architecture
Description	Cytochrome P450 11B2, mitochondrial precursor (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P-450Aldo) (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (Steroid 18-hydroxylase) (P-450C18).

ROBO3_HUMAN
NC score	0.002638 (rank : 91)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	570	Shared Neighborhood Hits	3
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

KIF6_HUMAN
NC score	0.001563 (rank : 92)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMV9, Q2MDE3, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4	Gene names	KIF6, C6orf102
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF6.