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Network neighborhood for query Sequence : NALP4_HUMAN

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NALP4_HUMAN
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NAL14_HUMAN
θ value	0 (rank : 1)	NC score	0.983506 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NAL11_HUMAN
θ value	1.37145e-157 (rank : 3)	NC score	0.965805 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NAL13_HUMAN
θ value	3.27947e-143 (rank : 4)	NC score	0.976122 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	43
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NAL12_HUMAN
θ value	2.19974e-139 (rank : 5)	NC score	0.973527 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NALP2_HUMAN
θ value	2.0589e-137 (rank : 6)	NC score	0.975627 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	65	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

CIAS1_HUMAN
θ value	2.689e-137 (rank : 7)	NC score	0.971967 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
θ value	1.6882e-131 (rank : 8)	NC score	0.971850 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	67	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NALP5_HUMAN
θ value	4.5974e-129 (rank : 9)	NC score	0.965515 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP5_MOUSE
θ value	4.02752e-125 (rank : 10)	NC score	0.897776 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	560	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP7_HUMAN
θ value	1.48236e-119 (rank : 11)	NC score	0.970014 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP1_HUMAN
θ value	1.49618e-87 (rank : 12)	NC score	0.919168 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	138	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP6_HUMAN
θ value	1.31376e-75 (rank : 13)	NC score	0.935168 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
θ value	1.60597e-73 (rank : 14)	NC score	0.934200 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NAL10_HUMAN
θ value	6.77864e-56 (rank : 15)	NC score	0.898128 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	32
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	7.01481e-53 (rank : 16)	NC score	0.895595 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

RINI_MOUSE
θ value	1.36902e-48 (rank : 17)	NC score	0.875030 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

RINI_HUMAN
θ value	6.58091e-43 (rank : 18)	NC score	0.876642 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	78	Shared Neighborhood Hits	37
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

CAR15_MOUSE
θ value	8.08199e-25 (rank : 19)	NC score	0.753117 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
θ value	2.87452e-22 (rank : 20)	NC score	0.732728 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	77	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_HUMAN
θ value	4.9032e-22 (rank : 21)	NC score	0.707845 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	102	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
θ value	4.29542e-18 (rank : 22)	NC score	0.709147 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	85	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

LRC34_MOUSE
θ value	1.133e-10 (rank : 23)	NC score	0.535279 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

C2TA_HUMAN
θ value	1.63604e-09 (rank : 24)	NC score	0.593350 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	34
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
θ value	2.13673e-09 (rank : 25)	NC score	0.571808 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

C2TA_MOUSE
θ value	6.21693e-09 (rank : 26)	NC score	0.615286 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

BIRC1_HUMAN
θ value	1.99992e-07 (rank : 27)	NC score	0.268038 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
θ value	3.41135e-07 (rank : 28)	NC score	0.250926 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

LRC31_HUMAN
θ value	2.21117e-06 (rank : 29)	NC score	0.514272 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

MEFV_HUMAN
θ value	1.09739e-05 (rank : 30)	NC score	0.097431 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

BIR1B_MOUSE
θ value	3.19293e-05 (rank : 31)	NC score	0.230941 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1F_MOUSE
θ value	5.44631e-05 (rank : 32)	NC score	0.244077 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	88	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

MEFV_MOUSE
θ value	0.000121331 (rank : 33)	NC score	0.171444 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

BIR1E_MOUSE
θ value	0.00020696 (rank : 34)	NC score	0.241814 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
θ value	0.000270298 (rank : 35)	NC score	0.236135 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

CF154_HUMAN
θ value	0.000786445 (rank : 36)	NC score	0.510317 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC45_MOUSE
θ value	0.00102713 (rank : 37)	NC score	0.180963 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
θ value	0.00175202 (rank : 38)	NC score	0.170261 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	933	Shared Neighborhood Hits	39
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CAR12_HUMAN
θ value	0.00869519 (rank : 39)	NC score	0.350604 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

FXL13_HUMAN
θ value	0.0148317 (rank : 40)	NC score	0.045019 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

RGP1_MOUSE
θ value	0.0252991 (rank : 41)	NC score	0.327309 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

TMOD4_HUMAN
θ value	0.0330416 (rank : 42)	NC score	0.086965 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	37	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZQ9, Q8WVL3, Q9UKH2	Gene names	TMOD4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

PZRN3_MOUSE
θ value	0.0431538 (rank : 43)	NC score	0.015823 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	447	Shared Neighborhood Hits	3
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RGP1_HUMAN
θ value	0.0961366 (rank : 44)	NC score	0.341634 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

TMOD4_MOUSE
θ value	0.0961366 (rank : 45)	NC score	0.083618 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLH8	Gene names	Tmod4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

TLR3_MOUSE
θ value	0.21417 (rank : 46)	NC score	0.011861 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	298	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

AIM2_HUMAN
θ value	0.279714 (rank : 47)	NC score	0.054156 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	O14862	Gene names	AIM2
Domain Architecture
Description	Interferon-inducible protein AIM2 (Absent in melanoma 2).

TMOD2_MOUSE
θ value	0.365318 (rank : 48)	NC score	0.079906 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

YMEL1_HUMAN
θ value	0.365318 (rank : 49)	NC score	0.014973 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

YMEL1_MOUSE
θ value	0.365318 (rank : 50)	NC score	0.014684 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

ASC_MOUSE
θ value	0.62314 (rank : 51)	NC score	0.279750 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

KR121_HUMAN
θ value	0.62314 (rank : 52)	NC score	0.027376 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	P59990	Gene names	KRTAP12-1, KAP12.1, KRTAP12.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 12-1 (Keratin-associated protein 12.1) (High sulfur keratin-associated protein 12.1).

TMOD3_HUMAN
θ value	0.62314 (rank : 53)	NC score	0.073725 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NYL9, Q9NT43, Q9NZR0	Gene names	TMOD3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

KR410_HUMAN
θ value	0.813845 (rank : 54)	NC score	0.016851 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

NTBP1_MOUSE
θ value	0.813845 (rank : 55)	NC score	0.017440 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	528	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

TMOD2_HUMAN
θ value	1.06291 (rank : 56)	NC score	0.086653 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	29	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

KGUA_MOUSE
θ value	1.38821 (rank : 57)	NC score	0.017227 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.015673 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KR102_HUMAN
θ value	1.81305 (rank : 59)	NC score	0.008375 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

S13A4_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.010616 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKG4	Gene names	SLC13A4, SUT1
Domain Architecture
Description	Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1).

TMOD3_MOUSE
θ value	1.81305 (rank : 61)	NC score	0.079877 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	34	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

EMR1_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.000938 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	349	Shared Neighborhood Hits	2
SwissProt Accessions	Q61549	Gene names	Emr1, Gpf480
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor) (Cell surface glycoprotein F4/80).

RABE1_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.006093 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	1104	Shared Neighborhood Hits	9
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.006218 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	1105	Shared Neighborhood Hits	9
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

NU5M_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.013112 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P03915, Q34773, Q8WCY3	Gene names	MT-ND5, MTND5, NADH5, ND5
Domain Architecture
Description	NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5).

PZRN4_HUMAN
θ value	4.03905 (rank : 66)	NC score	0.011752 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

UBP34_MOUSE
θ value	4.03905 (rank : 67)	NC score	0.010619 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

ZN750_MOUSE
θ value	4.03905 (rank : 68)	NC score	0.008080 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	346	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

GOGA4_MOUSE
θ value	5.27518 (rank : 69)	NC score	-0.000016 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	1939	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

PHLPP_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.021183 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	394	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

U334_MOUSE
θ value	5.27518 (rank : 71)	NC score	0.012766 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQA9	Gene names
Domain Architecture	No domain graphic available
Description	Probable UPF0334 kinase-like protein C1orf57 homolog.

KR123_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.012188 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	75	Shared Neighborhood Hits	6
SwissProt Accessions	P60328	Gene names	KRTAP12-3, KAP12.3, KRTAP12.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 12-3 (Keratin-associated protein 12.3) (High sulfur keratin-associated protein 12.3).

NTBP1_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.018803 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T7V8, Q49A22, Q6P1P9, Q9HAE6, Q9Y350	Gene names	SCYL1BP1, NTKLBP1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

PRDM4_HUMAN
θ value	6.88961 (rank : 74)	NC score	-0.003421 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	749	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKN5, Q9UFA6	Gene names	PRDM4, PFM1
Domain Architecture
Description	PR domain zinc finger protein 4 (PR domain-containing protein 4).

PRDM4_MOUSE
θ value	6.88961 (rank : 75)	NC score	-0.003427 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	744	Shared Neighborhood Hits	4
SwissProt Accessions	Q80V63	Gene names	Prdm4
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 4 (PR domain-containing protein 4).

TRP13_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.016032 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

JIP3_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.002824 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	759	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

KR10B_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.005171 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	269	Shared Neighborhood Hits	6
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

LRC14_HUMAN
θ value	8.99809 (rank : 79)	NC score	0.089966 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

TRP13_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.015288 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

ZN558_HUMAN
θ value	8.99809 (rank : 81)	NC score	-0.004358 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	748	Shared Neighborhood Hits	4
SwissProt Accessions	Q96NG5	Gene names	ZNF558
Domain Architecture	No domain graphic available
Description	Zinc finger protein 558.

ASC_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.219026 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

BIRC2_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.053742 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.054900 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC4_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.050275 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.051370 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

CARD8_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.115685 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

CD14_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.055877 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	104	Shared Neighborhood Hits	7
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

LMD1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.061973 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	169	Shared Neighborhood Hits	14
SwissProt Accessions	P29536	Gene names	LMOD1
Domain Architecture
Description	Leiomodin-1 (Leiomodin, muscle form) (64 kDa autoantigen D1) (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (Thyroid-associated ophthalmopathy autoantigen) (Smooth muscle leiomodin) (SM-Lmod).

MAPE_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.052117 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

TMOD1_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.071431 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	32	Shared Neighborhood Hits	16
SwissProt Accessions	P28289, Q9BUF1	Gene names	TMOD1, TMOD
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

TMOD1_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.072721 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P49813, Q9ERR9	Gene names	Tmod1, Tmod
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

Hits sorted by NC score

NALP4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NAL14_HUMAN
NC score	0.983506 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NAL13_HUMAN
NC score	0.976122 (rank : 3)	θ value	3.27947e-143 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	43
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP2_HUMAN
NC score	0.975627 (rank : 4)	θ value	2.0589e-137 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	65	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL12_HUMAN
NC score	0.973527 (rank : 5)	θ value	2.19974e-139 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_HUMAN
NC score	0.971967 (rank : 6)	θ value	2.689e-137 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
NC score	0.971850 (rank : 7)	θ value	1.6882e-131 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	67	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NALP7_HUMAN
NC score	0.970014 (rank : 8)	θ value	1.48236e-119 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL11_HUMAN
NC score	0.965805 (rank : 9)	θ value	1.37145e-157 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP5_HUMAN
NC score	0.965515 (rank : 10)	θ value	4.5974e-129 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP6_HUMAN
NC score	0.935168 (rank : 11)	θ value	1.31376e-75 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
NC score	0.934200 (rank : 12)	θ value	1.60597e-73 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP1_HUMAN
NC score	0.919168 (rank : 13)	θ value	1.49618e-87 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	138	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NAL10_HUMAN
NC score	0.898128 (rank : 14)	θ value	6.77864e-56 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	32
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NALP5_MOUSE
NC score	0.897776 (rank : 15)	θ value	4.02752e-125 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	560	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NAL10_MOUSE
NC score	0.895595 (rank : 16)	θ value	7.01481e-53 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

RINI_HUMAN
NC score	0.876642 (rank : 17)	θ value	6.58091e-43 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	78	Shared Neighborhood Hits	37
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
NC score	0.875030 (rank : 18)	θ value	1.36902e-48 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CAR15_MOUSE
NC score	0.753117 (rank : 19)	θ value	8.08199e-25 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.732728 (rank : 20)	θ value	2.87452e-22 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	77	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_MOUSE
NC score	0.709147 (rank : 21)	θ value	4.29542e-18 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	85	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CARD4_HUMAN
NC score	0.707845 (rank : 22)	θ value	4.9032e-22 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	102	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

C2TA_MOUSE
NC score	0.615286 (rank : 23)	θ value	6.21693e-09 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
NC score	0.593350 (rank : 24)	θ value	1.63604e-09 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	34
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
NC score	0.571808 (rank : 25)	θ value	2.13673e-09 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC34_MOUSE
NC score	0.535279 (rank : 26)	θ value	1.133e-10 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC31_HUMAN
NC score	0.514272 (rank : 27)	θ value	2.21117e-06 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

CF154_HUMAN
NC score	0.510317 (rank : 28)	θ value	0.000786445 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

CAR12_HUMAN
NC score	0.350604 (rank : 29)	θ value	0.00869519 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

RGP1_HUMAN
NC score	0.341634 (rank : 30)	θ value	0.0961366 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.327309 (rank : 31)	θ value	0.0252991 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

ASC_MOUSE
NC score	0.279750 (rank : 32)	θ value	0.62314 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

BIRC1_HUMAN
NC score	0.268038 (rank : 33)	θ value	1.99992e-07 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
NC score	0.250926 (rank : 34)	θ value	3.41135e-07 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1F_MOUSE
NC score	0.244077 (rank : 35)	θ value	5.44631e-05 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	88	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.241814 (rank : 36)	θ value	0.00020696 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.236135 (rank : 37)	θ value	0.000270298 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.230941 (rank : 38)	θ value	3.19293e-05 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

ASC_HUMAN
NC score	0.219026 (rank : 39)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

LRC45_MOUSE
NC score	0.180963 (rank : 40)	θ value	0.00102713 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MEFV_MOUSE
NC score	0.171444 (rank : 41)	θ value	0.000121331 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

LRC45_HUMAN
NC score	0.170261 (rank : 42)	θ value	0.00175202 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	933	Shared Neighborhood Hits	39
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CARD8_HUMAN
NC score	0.115685 (rank : 43)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

MEFV_HUMAN
NC score	0.097431 (rank : 44)	θ value	1.09739e-05 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LRC14_HUMAN
NC score	0.089966 (rank : 45)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

TMOD4_HUMAN
NC score	0.086965 (rank : 46)	θ value	0.0330416 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	37	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZQ9, Q8WVL3, Q9UKH2	Gene names	TMOD4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

TMOD2_HUMAN
NC score	0.086653 (rank : 47)	θ value	1.06291 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	29	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD4_MOUSE
NC score	0.083618 (rank : 48)	θ value	0.0961366 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLH8	Gene names	Tmod4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

TMOD2_MOUSE
NC score	0.079906 (rank : 49)	θ value	0.365318 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD3_MOUSE
NC score	0.079877 (rank : 50)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	34	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

TMOD3_HUMAN
NC score	0.073725 (rank : 51)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NYL9, Q9NT43, Q9NZR0	Gene names	TMOD3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

TMOD1_MOUSE
NC score	0.072721 (rank : 52)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P49813, Q9ERR9	Gene names	Tmod1, Tmod
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

TMOD1_HUMAN
NC score	0.071431 (rank : 53)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	32	Shared Neighborhood Hits	16
SwissProt Accessions	P28289, Q9BUF1	Gene names	TMOD1, TMOD
Domain Architecture
Description	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod).

LMD1_HUMAN
NC score	0.061973 (rank : 54)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	169	Shared Neighborhood Hits	14
SwissProt Accessions	P29536	Gene names	LMOD1
Domain Architecture
Description	Leiomodin-1 (Leiomodin, muscle form) (64 kDa autoantigen D1) (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (Thyroid-associated ophthalmopathy autoantigen) (Smooth muscle leiomodin) (SM-Lmod).

CD14_MOUSE
NC score	0.055877 (rank : 55)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	104	Shared Neighborhood Hits	7
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

BIRC2_MOUSE
NC score	0.054900 (rank : 56)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

AIM2_HUMAN
NC score	0.054156 (rank : 57)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	O14862	Gene names	AIM2
Domain Architecture
Description	Interferon-inducible protein AIM2 (Absent in melanoma 2).

BIRC2_HUMAN
NC score	0.053742 (rank : 58)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

MAPE_HUMAN
NC score	0.052117 (rank : 59)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

BIRC4_MOUSE
NC score	0.051370 (rank : 60)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC4_HUMAN
NC score	0.050275 (rank : 61)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

FXL13_HUMAN
NC score	0.045019 (rank : 62)	θ value	0.0148317 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

KR121_HUMAN
NC score	0.027376 (rank : 63)	θ value	0.62314 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	P59990	Gene names	KRTAP12-1, KAP12.1, KRTAP12.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 12-1 (Keratin-associated protein 12.1) (High sulfur keratin-associated protein 12.1).

PHLPP_MOUSE
NC score	0.021183 (rank : 64)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	394	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

NTBP1_HUMAN
NC score	0.018803 (rank : 65)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T7V8, Q49A22, Q6P1P9, Q9HAE6, Q9Y350	Gene names	SCYL1BP1, NTKLBP1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

NTBP1_MOUSE
NC score	0.017440 (rank : 66)	θ value	0.813845 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	528	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

KGUA_MOUSE
NC score	0.017227 (rank : 67)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KR410_HUMAN
NC score	0.016851 (rank : 68)	θ value	0.813845 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

TRP13_MOUSE
NC score	0.016032 (rank : 69)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

PZRN3_MOUSE
NC score	0.015823 (rank : 70)	θ value	0.0431538 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	447	Shared Neighborhood Hits	3
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

KGUA_HUMAN
NC score	0.015673 (rank : 71)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

TRP13_HUMAN
NC score	0.015288 (rank : 72)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

YMEL1_HUMAN
NC score	0.014973 (rank : 73)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

YMEL1_MOUSE
NC score	0.014684 (rank : 74)	θ value	0.365318 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

NU5M_HUMAN
NC score	0.013112 (rank : 75)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P03915, Q34773, Q8WCY3	Gene names	MT-ND5, MTND5, NADH5, ND5
Domain Architecture
Description	NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3) (NADH dehydrogenase subunit 5).

U334_MOUSE
NC score	0.012766 (rank : 76)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQA9	Gene names
Domain Architecture	No domain graphic available
Description	Probable UPF0334 kinase-like protein C1orf57 homolog.

KR123_HUMAN
NC score	0.012188 (rank : 77)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	75	Shared Neighborhood Hits	6
SwissProt Accessions	P60328	Gene names	KRTAP12-3, KAP12.3, KRTAP12.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 12-3 (Keratin-associated protein 12.3) (High sulfur keratin-associated protein 12.3).

TLR3_MOUSE
NC score	0.011861 (rank : 78)	θ value	0.21417 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	298	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

PZRN4_HUMAN
NC score	0.011752 (rank : 79)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

UBP34_MOUSE
NC score	0.010619 (rank : 80)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

S13A4_HUMAN
NC score	0.010616 (rank : 81)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKG4	Gene names	SLC13A4, SUT1
Domain Architecture
Description	Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1).

KR102_HUMAN
NC score	0.008375 (rank : 82)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

ZN750_MOUSE
NC score	0.008080 (rank : 83)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	346	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

RABE1_MOUSE
NC score	0.006218 (rank : 84)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	1105	Shared Neighborhood Hits	9
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RABE1_HUMAN
NC score	0.006093 (rank : 85)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	1104	Shared Neighborhood Hits	9
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

KR10B_HUMAN
NC score	0.005171 (rank : 86)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	269	Shared Neighborhood Hits	6
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

JIP3_MOUSE
NC score	0.002824 (rank : 87)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	759	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

EMR1_MOUSE
NC score	0.000938 (rank : 88)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	349	Shared Neighborhood Hits	2
SwissProt Accessions	Q61549	Gene names	Emr1, Gpf480
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor) (Cell surface glycoprotein F4/80).

GOGA4_MOUSE
NC score	-0.000016 (rank : 89)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	1939	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

PRDM4_HUMAN
NC score	-0.003421 (rank : 90)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	749	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKN5, Q9UFA6	Gene names	PRDM4, PFM1
Domain Architecture
Description	PR domain zinc finger protein 4 (PR domain-containing protein 4).

PRDM4_MOUSE
NC score	-0.003427 (rank : 91)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	744	Shared Neighborhood Hits	4
SwissProt Accessions	Q80V63	Gene names	Prdm4
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 4 (PR domain-containing protein 4).

ZN558_HUMAN
NC score	-0.004358 (rank : 92)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	748	Shared Neighborhood Hits	4
SwissProt Accessions	Q96NG5	Gene names	ZNF558
Domain Architecture	No domain graphic available
Description	Zinc finger protein 558.