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Network neighborhood for query Sequence : NALP6_MOUSE

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NALP6_MOUSE
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NALP6_HUMAN
θ value	0 (rank : 1)	NC score	0.993117 (rank : 2)
Query Neighborhood Hits	55	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	55
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

CIAS1_HUMAN
θ value	6.25694e-102 (rank : 3)	NC score	0.948892 (rank : 3)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
θ value	1.44246e-98 (rank : 4)	NC score	0.947681 (rank : 4)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL12_HUMAN
θ value	1.88391e-98 (rank : 5)	NC score	0.944673 (rank : 5)
Query Neighborhood Hits	55	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NAL14_HUMAN
θ value	4.82422e-78 (rank : 6)	NC score	0.930973 (rank : 8)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	34
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP1_HUMAN
θ value	1.22964e-73 (rank : 7)	NC score	0.910068 (rank : 13)
Query Neighborhood Hits	55	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP4_HUMAN
θ value	1.60597e-73 (rank : 8)	NC score	0.934200 (rank : 7)
Query Neighborhood Hits	55	Target Neighborhood Hits	81	Shared Neighborhood Hits	38
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
θ value	1.96316e-71 (rank : 9)	NC score	0.930387 (rank : 9)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP5_HUMAN
θ value	2.17557e-62 (rank : 10)	NC score	0.908555 (rank : 14)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	35
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP7_HUMAN
θ value	1.84173e-61 (rank : 11)	NC score	0.934865 (rank : 6)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL10_HUMAN
θ value	2.48917e-58 (rank : 12)	NC score	0.929837 (rank : 10)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	4.24587e-58 (rank : 13)	NC score	0.926400 (rank : 11)
Query Neighborhood Hits	55	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NAL13_HUMAN
θ value	1.78386e-56 (rank : 14)	NC score	0.917306 (rank : 12)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP5_MOUSE
θ value	1.19655e-52 (rank : 15)	NC score	0.843119 (rank : 16)
Query Neighborhood Hits	55	Target Neighborhood Hits	560	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NAL11_HUMAN
θ value	9.18288e-45 (rank : 16)	NC score	0.899936 (rank : 15)
Query Neighborhood Hits	55	Target Neighborhood Hits	66	Shared Neighborhood Hits	30
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

C2TA_MOUSE
θ value	2.06002e-20 (rank : 17)	NC score	0.665727 (rank : 22)
Query Neighborhood Hits	55	Target Neighborhood Hits	131	Shared Neighborhood Hits	35
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CAR15_HUMAN
θ value	2.13179e-17 (rank : 18)	NC score	0.698672 (rank : 20)
Query Neighborhood Hits	55	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

RINI_HUMAN
θ value	2.13179e-17 (rank : 19)	NC score	0.779237 (rank : 17)
Query Neighborhood Hits	55	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
θ value	4.44505e-15 (rank : 20)	NC score	0.768782 (rank : 18)
Query Neighborhood Hits	55	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CARD4_MOUSE
θ value	1.29331e-14 (rank : 21)	NC score	0.667781 (rank : 21)
Query Neighborhood Hits	55	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CAR15_MOUSE
θ value	2.20605e-14 (rank : 22)	NC score	0.713553 (rank : 19)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

C2TA_HUMAN
θ value	3.76295e-14 (rank : 23)	NC score	0.634721 (rank : 24)
Query Neighborhood Hits	55	Target Neighborhood Hits	190	Shared Neighborhood Hits	28
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

CARD4_HUMAN
θ value	3.76295e-14 (rank : 24)	NC score	0.659385 (rank : 23)
Query Neighborhood Hits	55	Target Neighborhood Hits	102	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

ASC_HUMAN
θ value	4.45536e-07 (rank : 25)	NC score	0.328139 (rank : 30)
Query Neighborhood Hits	55	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

ASC_MOUSE
θ value	6.43352e-06 (rank : 26)	NC score	0.384596 (rank : 29)
Query Neighborhood Hits	55	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

BIR1F_MOUSE
θ value	7.1131e-05 (rank : 27)	NC score	0.234559 (rank : 36)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1A_MOUSE
θ value	9.29e-05 (rank : 28)	NC score	0.239591 (rank : 35)
Query Neighborhood Hits	55	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1E_MOUSE
θ value	0.000158464 (rank : 29)	NC score	0.232699 (rank : 37)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
θ value	0.00035302 (rank : 30)	NC score	0.225984 (rank : 38)
Query Neighborhood Hits	55	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

MEFV_MOUSE
θ value	0.00134147 (rank : 31)	NC score	0.176681 (rank : 40)
Query Neighborhood Hits	55	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

BIRC1_HUMAN
θ value	0.00509761 (rank : 32)	NC score	0.255729 (rank : 33)
Query Neighborhood Hits	55	Target Neighborhood Hits	61	Shared Neighborhood Hits	28
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1B_MOUSE
θ value	0.0252991 (rank : 33)	NC score	0.216269 (rank : 39)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

DYH9_HUMAN
θ value	0.0736092 (rank : 34)	NC score	0.022384 (rank : 50)
Query Neighborhood Hits	55	Target Neighborhood Hits	291	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

MYLIP_MOUSE
θ value	0.279714 (rank : 35)	NC score	0.014802 (rank : 53)
Query Neighborhood Hits	55	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CLPX_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.030041 (rank : 49)
Query Neighborhood Hits	55	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

VPP2_MOUSE
θ value	0.813845 (rank : 37)	NC score	0.019119 (rank : 51)
Query Neighborhood Hits	55	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

LRC34_HUMAN
θ value	1.06291 (rank : 38)	NC score	0.439672 (rank : 25)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

RASA2_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.009415 (rank : 59)
Query Neighborhood Hits	55	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

TMOD2_MOUSE
θ value	1.06291 (rank : 40)	NC score	0.051090 (rank : 47)
Query Neighborhood Hits	55	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

VPP2_HUMAN
θ value	1.06291 (rank : 41)	NC score	0.018590 (rank : 52)
Query Neighborhood Hits	55	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y487	Gene names	ATP6V0A2
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (TJ6).

ABTB2_MOUSE
θ value	1.38821 (rank : 42)	NC score	0.011062 (rank : 54)
Query Neighborhood Hits	55	Target Neighborhood Hits	414	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

CAR12_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.310367 (rank : 31)
Query Neighborhood Hits	55	Target Neighborhood Hits	132	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CF154_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.413047 (rank : 26)
Query Neighborhood Hits	55	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC34_MOUSE
θ value	2.36792 (rank : 45)	NC score	0.399470 (rank : 27)
Query Neighborhood Hits	55	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

ABTB2_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.009661 (rank : 57)
Query Neighborhood Hits	55	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

TMOD2_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.056333 (rank : 46)
Query Neighborhood Hits	55	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

COE1_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.010219 (rank : 55)
Query Neighborhood Hits	55	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UH73, Q8IW11	Gene names	EBF1, COE1, EBF
Domain Architecture
Description	Transcription factor COE1 (OE-1) (O/E-1) (Early B-cell factor).

COE1_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.010219 (rank : 56)
Query Neighborhood Hits	55	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q07802	Gene names	Ebf1, Coe1, Ebf
Domain Architecture
Description	Transcription factor COE1 (OE-1) (O/E-1) (Early B-cell factor).

ACLY_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.009538 (rank : 58)
Query Neighborhood Hits	55	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V92	Gene names	Acly
Domain Architecture
Description	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).

ETS1_MOUSE
θ value	6.88961 (rank : 51)	NC score	0.003506 (rank : 63)
Query Neighborhood Hits	55	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	P27577, Q61403	Gene names	Ets1, Ets-1
Domain Architecture
Description	C-ets-1 protein (p54).

HDAC7_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.004287 (rank : 62)
Query Neighborhood Hits	55	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

LIPB1_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.002933 (rank : 64)
Query Neighborhood Hits	55	Target Neighborhood Hits	640	Shared Neighborhood Hits	3
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

ESCO1_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.009228 (rank : 60)
Query Neighborhood Hits	55	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

LIPB1_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.004722 (rank : 61)
Query Neighborhood Hits	55	Target Neighborhood Hits	727	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

BIRC2_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.050842 (rank : 48)
Query Neighborhood Hits	55	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

CARD8_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.126744 (rank : 42)
Query Neighborhood Hits	55	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

LRC14_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.073139 (rank : 45)
Query Neighborhood Hits	55	Target Neighborhood Hits	57	Shared Neighborhood Hits	15
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

LRC31_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.398295 (rank : 28)
Query Neighborhood Hits	55	Target Neighborhood Hits	139	Shared Neighborhood Hits	29
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC45_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.122938 (rank : 43)
Query Neighborhood Hits	55	Target Neighborhood Hits	933	Shared Neighborhood Hits	26
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.132105 (rank : 41)
Query Neighborhood Hits	55	Target Neighborhood Hits	959	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MEFV_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.089046 (rank : 44)
Query Neighborhood Hits	55	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

RGP1_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.263275 (rank : 32)
Query Neighborhood Hits	55	Target Neighborhood Hits	124	Shared Neighborhood Hits	20
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.251852 (rank : 34)
Query Neighborhood Hits	55	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

Hits sorted by NC score

NALP6_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	55
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP6_HUMAN
NC score	0.993117 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	55	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

CIAS1_HUMAN
NC score	0.948892 (rank : 3)	θ value	6.25694e-102 (rank : 3)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
NC score	0.947681 (rank : 4)	θ value	1.44246e-98 (rank : 4)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL12_HUMAN
NC score	0.944673 (rank : 5)	θ value	1.88391e-98 (rank : 5)
Query Neighborhood Hits	55	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NALP7_HUMAN
NC score	0.934865 (rank : 6)	θ value	1.84173e-61 (rank : 11)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP4_HUMAN
NC score	0.934200 (rank : 7)	θ value	1.60597e-73 (rank : 8)
Query Neighborhood Hits	55	Target Neighborhood Hits	81	Shared Neighborhood Hits	38
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NAL14_HUMAN
NC score	0.930973 (rank : 8)	θ value	4.82422e-78 (rank : 6)
Query Neighborhood Hits	55	Target Neighborhood Hits	76	Shared Neighborhood Hits	34
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP2_HUMAN
NC score	0.930387 (rank : 9)	θ value	1.96316e-71 (rank : 9)
Query Neighborhood Hits	55	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL10_HUMAN
NC score	0.929837 (rank : 10)	θ value	2.48917e-58 (rank : 12)
Query Neighborhood Hits	55	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
NC score	0.926400 (rank : 11)	θ value	4.24587e-58 (rank : 13)
Query Neighborhood Hits	55	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NAL13_HUMAN
NC score	0.917306 (rank : 12)	θ value	1.78386e-56 (rank : 14)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP1_HUMAN
NC score	0.910068 (rank : 13)	θ value	1.22964e-73 (rank : 7)
Query Neighborhood Hits	55	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP5_HUMAN
NC score	0.908555 (rank : 14)	θ value	2.17557e-62 (rank : 10)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	35
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL11_HUMAN
NC score	0.899936 (rank : 15)	θ value	9.18288e-45 (rank : 16)
Query Neighborhood Hits	55	Target Neighborhood Hits	66	Shared Neighborhood Hits	30
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP5_MOUSE
NC score	0.843119 (rank : 16)	θ value	1.19655e-52 (rank : 15)
Query Neighborhood Hits	55	Target Neighborhood Hits	560	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RINI_HUMAN
NC score	0.779237 (rank : 17)	θ value	2.13179e-17 (rank : 19)
Query Neighborhood Hits	55	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
NC score	0.768782 (rank : 18)	θ value	4.44505e-15 (rank : 20)
Query Neighborhood Hits	55	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CAR15_MOUSE
NC score	0.713553 (rank : 19)	θ value	2.20605e-14 (rank : 22)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.698672 (rank : 20)	θ value	2.13179e-17 (rank : 18)
Query Neighborhood Hits	55	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_MOUSE
NC score	0.667781 (rank : 21)	θ value	1.29331e-14 (rank : 21)
Query Neighborhood Hits	55	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_MOUSE
NC score	0.665727 (rank : 22)	θ value	2.06002e-20 (rank : 17)
Query Neighborhood Hits	55	Target Neighborhood Hits	131	Shared Neighborhood Hits	35
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CARD4_HUMAN
NC score	0.659385 (rank : 23)	θ value	3.76295e-14 (rank : 24)
Query Neighborhood Hits	55	Target Neighborhood Hits	102	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

C2TA_HUMAN
NC score	0.634721 (rank : 24)	θ value	3.76295e-14 (rank : 23)
Query Neighborhood Hits	55	Target Neighborhood Hits	190	Shared Neighborhood Hits	28
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
NC score	0.439672 (rank : 25)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	55	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CF154_HUMAN
NC score	0.413047 (rank : 26)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	55	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC34_MOUSE
NC score	0.399470 (rank : 27)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	55	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC31_HUMAN
NC score	0.398295 (rank : 28)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	55	Target Neighborhood Hits	139	Shared Neighborhood Hits	29
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

ASC_MOUSE
NC score	0.384596 (rank : 29)	θ value	6.43352e-06 (rank : 26)
Query Neighborhood Hits	55	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

ASC_HUMAN
NC score	0.328139 (rank : 30)	θ value	4.45536e-07 (rank : 25)
Query Neighborhood Hits	55	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

CAR12_HUMAN
NC score	0.310367 (rank : 31)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	55	Target Neighborhood Hits	132	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

RGP1_HUMAN
NC score	0.263275 (rank : 32)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	55	Target Neighborhood Hits	124	Shared Neighborhood Hits	20
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

BIRC1_HUMAN
NC score	0.255729 (rank : 33)	θ value	0.00509761 (rank : 32)
Query Neighborhood Hits	55	Target Neighborhood Hits	61	Shared Neighborhood Hits	28
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

RGP1_MOUSE
NC score	0.251852 (rank : 34)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	55	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

BIR1A_MOUSE
NC score	0.239591 (rank : 35)	θ value	9.29e-05 (rank : 28)
Query Neighborhood Hits	55	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1F_MOUSE
NC score	0.234559 (rank : 36)	θ value	7.1131e-05 (rank : 27)
Query Neighborhood Hits	55	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.232699 (rank : 37)	θ value	0.000158464 (rank : 29)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.225984 (rank : 38)	θ value	0.00035302 (rank : 30)
Query Neighborhood Hits	55	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.216269 (rank : 39)	θ value	0.0252991 (rank : 33)
Query Neighborhood Hits	55	Target Neighborhood Hits	93	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

MEFV_MOUSE
NC score	0.176681 (rank : 40)	θ value	0.00134147 (rank : 31)
Query Neighborhood Hits	55	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

LRC45_MOUSE
NC score	0.132105 (rank : 41)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	55	Target Neighborhood Hits	959	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CARD8_HUMAN
NC score	0.126744 (rank : 42)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	55	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

LRC45_HUMAN
NC score	0.122938 (rank : 43)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	55	Target Neighborhood Hits	933	Shared Neighborhood Hits	26
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MEFV_HUMAN
NC score	0.089046 (rank : 44)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	55	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LRC14_HUMAN
NC score	0.073139 (rank : 45)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	55	Target Neighborhood Hits	57	Shared Neighborhood Hits	15
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

TMOD2_HUMAN
NC score	0.056333 (rank : 46)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	55	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD2_MOUSE
NC score	0.051090 (rank : 47)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	55	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

BIRC2_MOUSE
NC score	0.050842 (rank : 48)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	55	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

CLPX_HUMAN
NC score	0.030041 (rank : 49)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	55	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

DYH9_HUMAN
NC score	0.022384 (rank : 50)	θ value	0.0736092 (rank : 34)
Query Neighborhood Hits	55	Target Neighborhood Hits	291	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

VPP2_MOUSE
NC score	0.019119 (rank : 51)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	55	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

VPP2_HUMAN
NC score	0.018590 (rank : 52)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	55	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y487	Gene names	ATP6V0A2
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (TJ6).

MYLIP_MOUSE
NC score	0.014802 (rank : 53)	θ value	0.279714 (rank : 35)
Query Neighborhood Hits	55	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

ABTB2_MOUSE
NC score	0.011062 (rank : 54)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	55	Target Neighborhood Hits	414	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

COE1_HUMAN
NC score	0.010219 (rank : 55)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	55	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UH73, Q8IW11	Gene names	EBF1, COE1, EBF
Domain Architecture
Description	Transcription factor COE1 (OE-1) (O/E-1) (Early B-cell factor).

COE1_MOUSE
NC score	0.010219 (rank : 56)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	55	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q07802	Gene names	Ebf1, Coe1, Ebf
Domain Architecture
Description	Transcription factor COE1 (OE-1) (O/E-1) (Early B-cell factor).

ABTB2_HUMAN
NC score	0.009661 (rank : 57)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	55	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ACLY_MOUSE
NC score	0.009538 (rank : 58)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	55	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V92	Gene names	Acly
Domain Architecture
Description	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).

RASA2_HUMAN
NC score	0.009415 (rank : 59)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	55	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

ESCO1_HUMAN
NC score	0.009228 (rank : 60)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	55	Target Neighborhood Hits	361	Shared Neighborhood Hits	4
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

LIPB1_MOUSE
NC score	0.004722 (rank : 61)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	55	Target Neighborhood Hits	727	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

HDAC7_MOUSE
NC score	0.004287 (rank : 62)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	55	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

ETS1_MOUSE
NC score	0.003506 (rank : 63)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	55	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	P27577, Q61403	Gene names	Ets1, Ets-1
Domain Architecture
Description	C-ets-1 protein (p54).

LIPB1_HUMAN
NC score	0.002933 (rank : 64)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	55	Target Neighborhood Hits	640	Shared Neighborhood Hits	3
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).