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Network neighborhood for query Sequence : VPP2_HUMAN

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VPP2_HUMAN
SwissProt Accessions	Q9Y487	Gene names	ATP6V0A2
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (TJ6).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

VPP1_HUMAN
θ value	0 (rank : 1)	NC score	0.987313 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q93050, Q8N5G7, Q9NSX0	Gene names	ATP6V0A1, ATP6N1, VPP1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

VPP1_MOUSE
θ value	0 (rank : 2)	NC score	0.987074 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1G4, Q9JHJ4, Q9JL13, Q9JL14	Gene names	Atp6v0a1, Atp6n1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

VPP2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y487	Gene names	ATP6V0A2
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (TJ6).

VPP2_MOUSE
θ value	0 (rank : 4)	NC score	0.998238 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

VPP3_HUMAN
θ value	0 (rank : 5)	NC score	0.989286 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	Q13488, O75877	Gene names	TCIRG1, ATP6N1C, ATP6V0A3
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3 (V- ATPase 116 kDa isoform a3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T cell immune response cDNA7 protein) (TIRC7).

VPP4_HUMAN
θ value	0 (rank : 6)	NC score	0.984972 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBG4	Gene names	ATP6V0A4, ATP6N1B
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (V- ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform).

VPP4_MOUSE
θ value	0 (rank : 7)	NC score	0.984567 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	Q920R6, Q8CJ79, Q920B5	Gene names	Atp6v0a4, Atp6n1b
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (V- ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform).

CP135_HUMAN
θ value	0.279714 (rank : 8)	NC score	0.020983 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	1290	Shared Neighborhood Hits	21
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

BICD1_MOUSE
θ value	0.47712 (rank : 9)	NC score	0.029954 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	837	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

EEA1_MOUSE
θ value	0.813845 (rank : 10)	NC score	0.014839 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	1637	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SO1C1_MOUSE
θ value	0.813845 (rank : 11)	NC score	0.018686 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERB5, Q8BX54	Gene names	Slco1c1, Oatpf, Slc21a14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter 2) (OATP2).

INT2_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.035974 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q80UK8, Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q8CB15, Q9CSE0	Gene names	Ints2, Kiaa1287
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 2 (Int2).

NALP6_MOUSE
θ value	1.06291 (rank : 13)	NC score	0.018590 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

BICD1_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.027109 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	844	Shared Neighborhood Hits	21
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

DLG5_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.018675 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	1088	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

PDE6C_HUMAN
θ value	1.38821 (rank : 16)	NC score	0.015579 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

RAD50_MOUSE
θ value	1.38821 (rank : 17)	NC score	0.014965 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	1366	Shared Neighborhood Hits	21
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

SNX6_HUMAN
θ value	1.38821 (rank : 18)	NC score	0.027600 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNH7, Q9Y449	Gene names	SNX6
Domain Architecture
Description	Sorting nexin-6 (TRAF4-associated factor 2).

SNX6_MOUSE
θ value	1.38821 (rank : 19)	NC score	0.026776 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P8X1	Gene names	Snx6
Domain Architecture	No domain graphic available
Description	Sorting nexin-6.

SO1C1_HUMAN
θ value	1.38821 (rank : 20)	NC score	0.017276 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYB5	Gene names	SLCO1C1, OATPF, SLC21A14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATPRP5).

DESP_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.015042 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	1470	Shared Neighborhood Hits	23
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

SYNE2_HUMAN
θ value	2.36792 (rank : 22)	NC score	0.012076 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	1323	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

T2R48_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.006380 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P59542, Q645X8	Gene names	TAS2R48
Domain Architecture
Description	Taste receptor type 2 member 48 (T2R48).

ABI3_HUMAN
θ value	4.03905 (rank : 24)	NC score	0.014001 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

KINH_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.007937 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	1231	Shared Neighborhood Hits	21
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

NR6A1_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.007122 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	108	Shared Neighborhood Hits	3
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR6A1_MOUSE
θ value	4.03905 (rank : 27)	NC score	0.007113 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

SF3A3_HUMAN
θ value	4.03905 (rank : 28)	NC score	0.021856 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q12874, Q15460	Gene names	SF3A3, SAP61
Domain Architecture	No domain graphic available
Description	Splicing factor 3A subunit 3 (Spliceosome-associated protein 61) (SAP 61) (SF3a60).

SF3A3_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.021561 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D554	Gene names	Sf3a3, Sap61
Domain Architecture	No domain graphic available
Description	Splicing factor 3A subunit 3 (Spliceosome-associated protein 61) (SAP 61) (SF3a60).

BICD2_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.022933 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	856	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	5.27518 (rank : 31)	NC score	0.022488 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	864	Shared Neighborhood Hits	21
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

MYH1_MOUSE
θ value	5.27518 (rank : 32)	NC score	0.010434 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	1461	Shared Neighborhood Hits	22
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

PTPRT_MOUSE
θ value	5.27518 (rank : 33)	NC score	0.003696 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

RBCC1_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.012838 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	1023	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

SIA8F_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.013977 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4T1	Gene names	St8sia6, Siat8f
Domain Architecture
Description	Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (ST8Sia VI).

T2R39_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.007242 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	P59534, Q645W4	Gene names	TAS2R39
Domain Architecture
Description	Taste receptor type 2 member 39 (T2R39) (T2R57).

T2R40_MOUSE
θ value	5.27518 (rank : 37)	NC score	0.008475 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQB8	Gene names	Tas2r40, T2r33, Tas2r144, Tas2r44
Domain Architecture
Description	Taste receptor type 2 member 40 (T2R40) (mT2R33).

TRAP1_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.008782 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q12931, O43642, O75235, Q9UHL5	Gene names	TRAP1, HSP75
Domain Architecture
Description	Heat shock protein 75 kDa, mitochondrial precursor (HSP 75) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) (TNFR- associated protein 1).

BRE1B_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.014509 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	1040	Shared Neighborhood Hits	21
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.014892 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	970	Shared Neighborhood Hits	21
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

CP135_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.014717 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	1278	Shared Neighborhood Hits	22
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

MYH1_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.009682 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	1478	Shared Neighborhood Hits	22
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH3_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.009270 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	1660	Shared Neighborhood Hits	22
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

RAD50_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.013781 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	1317	Shared Neighborhood Hits	21
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

INT2_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.019337 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0H0, Q9ULD3	Gene names	INTS2, KIAA1287
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 2 (Int2).

STIM2_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.007858 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	420	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

Hits sorted by NC score

VPP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y487	Gene names	ATP6V0A2
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (TJ6).

VPP2_MOUSE
NC score	0.998238 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

VPP3_HUMAN
NC score	0.989286 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	Q13488, O75877	Gene names	TCIRG1, ATP6N1C, ATP6V0A3
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3 (V- ATPase 116 kDa isoform a3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T cell immune response cDNA7 protein) (TIRC7).

VPP1_HUMAN
NC score	0.987313 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q93050, Q8N5G7, Q9NSX0	Gene names	ATP6V0A1, ATP6N1, VPP1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

VPP1_MOUSE
NC score	0.987074 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1G4, Q9JHJ4, Q9JL13, Q9JL14	Gene names	Atp6v0a1, Atp6n1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

VPP4_HUMAN
NC score	0.984972 (rank : 6)	θ value	0 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HBG4	Gene names	ATP6V0A4, ATP6N1B
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (V- ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform).

VPP4_MOUSE
NC score	0.984567 (rank : 7)	θ value	0 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	Q920R6, Q8CJ79, Q920B5	Gene names	Atp6v0a4, Atp6n1b
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (V- ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform).

INT2_MOUSE
NC score	0.035974 (rank : 8)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q80UK8, Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q8CB15, Q9CSE0	Gene names	Ints2, Kiaa1287
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 2 (Int2).

BICD1_MOUSE
NC score	0.029954 (rank : 9)	θ value	0.47712 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	837	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

SNX6_HUMAN
NC score	0.027600 (rank : 10)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNH7, Q9Y449	Gene names	SNX6
Domain Architecture
Description	Sorting nexin-6 (TRAF4-associated factor 2).

BICD1_HUMAN
NC score	0.027109 (rank : 11)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	844	Shared Neighborhood Hits	21
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

SNX6_MOUSE
NC score	0.026776 (rank : 12)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P8X1	Gene names	Snx6
Domain Architecture	No domain graphic available
Description	Sorting nexin-6.

BICD2_HUMAN
NC score	0.022933 (rank : 13)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	856	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
NC score	0.022488 (rank : 14)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	864	Shared Neighborhood Hits	21
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

SF3A3_HUMAN
NC score	0.021856 (rank : 15)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q12874, Q15460	Gene names	SF3A3, SAP61
Domain Architecture	No domain graphic available
Description	Splicing factor 3A subunit 3 (Spliceosome-associated protein 61) (SAP 61) (SF3a60).

SF3A3_MOUSE
NC score	0.021561 (rank : 16)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D554	Gene names	Sf3a3, Sap61
Domain Architecture	No domain graphic available
Description	Splicing factor 3A subunit 3 (Spliceosome-associated protein 61) (SAP 61) (SF3a60).

CP135_HUMAN
NC score	0.020983 (rank : 17)	θ value	0.279714 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	1290	Shared Neighborhood Hits	21
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

INT2_HUMAN
NC score	0.019337 (rank : 18)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0H0, Q9ULD3	Gene names	INTS2, KIAA1287
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 2 (Int2).

SO1C1_MOUSE
NC score	0.018686 (rank : 19)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERB5, Q8BX54	Gene names	Slco1c1, Oatpf, Slc21a14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter 2) (OATP2).

DLG5_HUMAN
NC score	0.018675 (rank : 20)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	1088	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

NALP6_MOUSE
NC score	0.018590 (rank : 21)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

SO1C1_HUMAN
NC score	0.017276 (rank : 22)	θ value	1.38821 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NYB5	Gene names	SLCO1C1, OATPF, SLC21A14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATPRP5).

PDE6C_HUMAN
NC score	0.015579 (rank : 23)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

DESP_HUMAN
NC score	0.015042 (rank : 24)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	1470	Shared Neighborhood Hits	23
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

RAD50_MOUSE
NC score	0.014965 (rank : 25)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	1366	Shared Neighborhood Hits	21
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

BRE1B_MOUSE
NC score	0.014892 (rank : 26)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	970	Shared Neighborhood Hits	21
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

EEA1_MOUSE
NC score	0.014839 (rank : 27)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	1637	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

CP135_MOUSE
NC score	0.014717 (rank : 28)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	1278	Shared Neighborhood Hits	22
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

BRE1B_HUMAN
NC score	0.014509 (rank : 29)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	1040	Shared Neighborhood Hits	21
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

ABI3_HUMAN
NC score	0.014001 (rank : 30)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SIA8F_MOUSE
NC score	0.013977 (rank : 31)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4T1	Gene names	St8sia6, Siat8f
Domain Architecture
Description	Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (ST8Sia VI).

RAD50_HUMAN
NC score	0.013781 (rank : 32)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	1317	Shared Neighborhood Hits	21
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RBCC1_HUMAN
NC score	0.012838 (rank : 33)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	1023	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

SYNE2_HUMAN
NC score	0.012076 (rank : 34)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	1323	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MYH1_MOUSE
NC score	0.010434 (rank : 35)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	1461	Shared Neighborhood Hits	22
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH1_HUMAN
NC score	0.009682 (rank : 36)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	1478	Shared Neighborhood Hits	22
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH3_HUMAN
NC score	0.009270 (rank : 37)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	1660	Shared Neighborhood Hits	22
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

TRAP1_HUMAN
NC score	0.008782 (rank : 38)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q12931, O43642, O75235, Q9UHL5	Gene names	TRAP1, HSP75
Domain Architecture
Description	Heat shock protein 75 kDa, mitochondrial precursor (HSP 75) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) (TNFR- associated protein 1).

T2R40_MOUSE
NC score	0.008475 (rank : 39)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQB8	Gene names	Tas2r40, T2r33, Tas2r144, Tas2r44
Domain Architecture
Description	Taste receptor type 2 member 40 (T2R40) (mT2R33).

KINH_HUMAN
NC score	0.007937 (rank : 40)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	1231	Shared Neighborhood Hits	21
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

STIM2_HUMAN
NC score	0.007858 (rank : 41)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	420	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

T2R39_HUMAN
NC score	0.007242 (rank : 42)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	P59534, Q645W4	Gene names	TAS2R39
Domain Architecture
Description	Taste receptor type 2 member 39 (T2R39) (T2R57).

NR6A1_HUMAN
NC score	0.007122 (rank : 43)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	108	Shared Neighborhood Hits	3
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR6A1_MOUSE
NC score	0.007113 (rank : 44)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

T2R48_HUMAN
NC score	0.006380 (rank : 45)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P59542, Q645X8	Gene names	TAS2R48
Domain Architecture
Description	Taste receptor type 2 member 48 (T2R48).

PTPRT_MOUSE
NC score	0.003696 (rank : 46)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).