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Network neighborhood for query Sequence : PDE6C_HUMAN

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PDE6C_HUMAN
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE6A_HUMAN
θ value	0 (rank : 1)	NC score	0.996767 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6A_MOUSE
θ value	0 (rank : 2)	NC score	0.996882 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	39
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_HUMAN
θ value	0 (rank : 3)	NC score	0.997365 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
θ value	0 (rank : 4)	NC score	0.997253 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6C_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_MOUSE
θ value	0 (rank : 6)	NC score	0.999359 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	41
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE11_MOUSE
θ value	9.94316e-116 (rank : 7)	NC score	0.963381 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_HUMAN
θ value	1.29861e-115 (rank : 8)	NC score	0.963448 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE5A_MOUSE
θ value	8.73085e-104 (rank : 9)	NC score	0.960155 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
θ value	1.26073e-102 (rank : 10)	NC score	0.959139 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE2A_MOUSE
θ value	2.65329e-68 (rank : 11)	NC score	0.933088 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
θ value	3.4653e-68 (rank : 12)	NC score	0.931672 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE10_HUMAN
θ value	1.27544e-62 (rank : 13)	NC score	0.944663 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE4D_HUMAN
θ value	1.6247e-33 (rank : 14)	NC score	0.806558 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	122	Shared Neighborhood Hits	38
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4A_HUMAN
θ value	2.12192e-33 (rank : 15)	NC score	0.806304 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
θ value	2.77131e-33 (rank : 16)	NC score	0.806643 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4D_MOUSE
θ value	2.77131e-33 (rank : 17)	NC score	0.807305 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE9A_HUMAN
θ value	1.08979e-29 (rank : 18)	NC score	0.853302 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE4C_HUMAN
θ value	7.06379e-29 (rank : 19)	NC score	0.809267 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4B_HUMAN
θ value	1.57365e-28 (rank : 20)	NC score	0.798275 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_MOUSE
θ value	3.50572e-28 (rank : 21)	NC score	0.809858 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE9A_MOUSE
θ value	1.02001e-27 (rank : 22)	NC score	0.851321 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE1A_MOUSE
θ value	8.63488e-27 (rank : 23)	NC score	0.798865 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
θ value	2.51237e-26 (rank : 24)	NC score	0.796528 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1C_HUMAN
θ value	2.51237e-26 (rank : 25)	NC score	0.789127 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	2.51237e-26 (rank : 26)	NC score	0.788287 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE1B_MOUSE
θ value	4.28545e-26 (rank : 27)	NC score	0.799612 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1B_HUMAN
θ value	9.54697e-26 (rank : 28)	NC score	0.796338 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8A_HUMAN
θ value	1.05554e-24 (rank : 29)	NC score	0.784989 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7B_MOUSE
θ value	4.01107e-24 (rank : 30)	NC score	0.812390 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8A_MOUSE
θ value	8.93572e-24 (rank : 31)	NC score	0.779952 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE7B_HUMAN
θ value	1.99067e-23 (rank : 32)	NC score	0.809437 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8B_HUMAN
θ value	5.79196e-23 (rank : 33)	NC score	0.777284 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE7A_HUMAN
θ value	6.40375e-22 (rank : 34)	NC score	0.811582 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
θ value	5.42112e-21 (rank : 35)	NC score	0.807829 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE3A_HUMAN
θ value	4.02038e-16 (rank : 36)	NC score	0.730039 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
θ value	2.60593e-15 (rank : 37)	NC score	0.732570 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3B_HUMAN
θ value	1.42992e-13 (rank : 38)	NC score	0.733459 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

VPP2_MOUSE
θ value	0.21417 (rank : 39)	NC score	0.024216 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

ANGP2_MOUSE
θ value	1.06291 (rank : 40)	NC score	0.005291 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	397	Shared Neighborhood Hits	5
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

VPP2_HUMAN
θ value	1.38821 (rank : 41)	NC score	0.015579 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y487	Gene names	ATP6V0A2
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (TJ6).

NUDC3_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.012955 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IVD9, Q9BTI3, Q9H7W9, Q9UPT4	Gene names	NUDCD3, KIAA1068
Domain Architecture	No domain graphic available
Description	NudC domain-containing protein 3.

MOD5_HUMAN
θ value	3.0926 (rank : 43)	NC score	0.012018 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H3H1, Q6IAC9, Q96FJ3, Q96L45, Q9NXT7	Gene names	TRIT1, IPT, MOD5
Domain Architecture
Description	tRNA isopentenyltransferase, mitochondrial precursor (EC 2.5.1.8) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPTase) (IPPT) (hGRO1).

HIP1_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.000090 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	1016	Shared Neighborhood Hits	7
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

TLN1_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.008147 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	4.03905 (rank : 46)	NC score	0.008106 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	213	Shared Neighborhood Hits	5
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TXND3_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.010229 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q715T0, Q80W74	Gene names	Txndc3, Sptrx2
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 3 (Spermatid-specific thioredoxin-2) (Sptrx-2).

HMMR_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.002833 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	1178	Shared Neighborhood Hits	9
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

USH1C_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.004276 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	327	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.003641 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	557	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

ATR_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.006777 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.006790 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

CP24A_MOUSE
θ value	6.88961 (rank : 53)	NC score	0.000594 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	Q64441	Gene names	Cyp24a1, Cyp-24, Cyp24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

GRIK2_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.000930 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q13002	Gene names	GRIK2, GLUR6
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor 6) (GluR-6) (GluR6) (Excitatory amino acid receptor 4) (EAA4).

HPLN1_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.002010 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUP5, Q9D1G9, Q9Z1X7	Gene names	Hapln1, Crtl1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 1 precursor (Proteoglycan link protein) (Cartilage link protein) (LP).

NEST_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.003766 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	1305	Shared Neighborhood Hits	10
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

Hits sorted by NC score

PDE6C_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_MOUSE
NC score	0.999359 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	41
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6B_HUMAN
NC score	0.997365 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
NC score	0.997253 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_MOUSE
NC score	0.996882 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	39
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6A_HUMAN
NC score	0.996767 (rank : 6)	θ value	0 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE11_HUMAN
NC score	0.963448 (rank : 7)	θ value	1.29861e-115 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.963381 (rank : 8)	θ value	9.94316e-116 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE5A_MOUSE
NC score	0.960155 (rank : 9)	θ value	8.73085e-104 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.959139 (rank : 10)	θ value	1.26073e-102 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
NC score	0.944663 (rank : 11)	θ value	1.27544e-62 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE2A_MOUSE
NC score	0.933088 (rank : 12)	θ value	2.65329e-68 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.931672 (rank : 13)	θ value	3.4653e-68 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE9A_HUMAN
NC score	0.853302 (rank : 14)	θ value	1.08979e-29 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
NC score	0.851321 (rank : 15)	θ value	1.02001e-27 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE7B_MOUSE
NC score	0.812390 (rank : 16)	θ value	4.01107e-24 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_HUMAN
NC score	0.811582 (rank : 17)	θ value	6.40375e-22 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE4C_MOUSE
NC score	0.809858 (rank : 18)	θ value	3.50572e-28 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.809437 (rank : 19)	θ value	1.99067e-23 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE4C_HUMAN
NC score	0.809267 (rank : 20)	θ value	7.06379e-29 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE7A_MOUSE
NC score	0.807829 (rank : 21)	θ value	5.42112e-21 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE4D_MOUSE
NC score	0.807305 (rank : 22)	θ value	2.77131e-33 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_MOUSE
NC score	0.806643 (rank : 23)	θ value	2.77131e-33 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4D_HUMAN
NC score	0.806558 (rank : 24)	θ value	1.6247e-33 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	122	Shared Neighborhood Hits	38
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4A_HUMAN
NC score	0.806304 (rank : 25)	θ value	2.12192e-33 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE1B_MOUSE
NC score	0.799612 (rank : 26)	θ value	4.28545e-26 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_MOUSE
NC score	0.798865 (rank : 27)	θ value	8.63488e-27 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE4B_HUMAN
NC score	0.798275 (rank : 28)	θ value	1.57365e-28 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE1A_HUMAN
NC score	0.796528 (rank : 29)	θ value	2.51237e-26 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_HUMAN
NC score	0.796338 (rank : 30)	θ value	9.54697e-26 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1C_HUMAN
NC score	0.789127 (rank : 31)	θ value	2.51237e-26 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.788287 (rank : 32)	θ value	2.51237e-26 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE8A_HUMAN
NC score	0.784989 (rank : 33)	θ value	1.05554e-24 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE8A_MOUSE
NC score	0.779952 (rank : 34)	θ value	8.93572e-24 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE8B_HUMAN
NC score	0.777284 (rank : 35)	θ value	5.79196e-23 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE3B_HUMAN
NC score	0.733459 (rank : 36)	θ value	1.42992e-13 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_MOUSE
NC score	0.732570 (rank : 37)	θ value	2.60593e-15 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_HUMAN
NC score	0.730039 (rank : 38)	θ value	4.02038e-16 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

VPP2_MOUSE
NC score	0.024216 (rank : 39)	θ value	0.21417 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

VPP2_HUMAN
NC score	0.015579 (rank : 40)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y487	Gene names	ATP6V0A2
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (TJ6).

NUDC3_HUMAN
NC score	0.012955 (rank : 41)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IVD9, Q9BTI3, Q9H7W9, Q9UPT4	Gene names	NUDCD3, KIAA1068
Domain Architecture	No domain graphic available
Description	NudC domain-containing protein 3.

MOD5_HUMAN
NC score	0.012018 (rank : 42)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H3H1, Q6IAC9, Q96FJ3, Q96L45, Q9NXT7	Gene names	TRIT1, IPT, MOD5
Domain Architecture
Description	tRNA isopentenyltransferase, mitochondrial precursor (EC 2.5.1.8) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPTase) (IPPT) (hGRO1).

TXND3_MOUSE
NC score	0.010229 (rank : 43)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q715T0, Q80W74	Gene names	Txndc3, Sptrx2
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 3 (Spermatid-specific thioredoxin-2) (Sptrx-2).

TLN1_HUMAN
NC score	0.008147 (rank : 44)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
NC score	0.008106 (rank : 45)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	213	Shared Neighborhood Hits	5
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

ATR_MOUSE
NC score	0.006790 (rank : 46)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATR_HUMAN
NC score	0.006777 (rank : 47)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ANGP2_MOUSE
NC score	0.005291 (rank : 48)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	397	Shared Neighborhood Hits	5
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

USH1C_HUMAN
NC score	0.004276 (rank : 49)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	327	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

NEST_HUMAN
NC score	0.003766 (rank : 50)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	1305	Shared Neighborhood Hits	10
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

USH1C_MOUSE
NC score	0.003641 (rank : 51)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	557	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

HMMR_MOUSE
NC score	0.002833 (rank : 52)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	1178	Shared Neighborhood Hits	9
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

HPLN1_MOUSE
NC score	0.002010 (rank : 53)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUP5, Q9D1G9, Q9Z1X7	Gene names	Hapln1, Crtl1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 1 precursor (Proteoglycan link protein) (Cartilage link protein) (LP).

GRIK2_HUMAN
NC score	0.000930 (rank : 54)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q13002	Gene names	GRIK2, GLUR6
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor 6) (GluR-6) (GluR6) (Excitatory amino acid receptor 4) (EAA4).

CP24A_MOUSE
NC score	0.000594 (rank : 55)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	Q64441	Gene names	Cyp24a1, Cyp-24, Cyp24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

HIP1_HUMAN
NC score	0.000090 (rank : 56)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	1016	Shared Neighborhood Hits	7
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).