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Network neighborhood for query Sequence : PDE9A_MOUSE

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PDE9A_MOUSE
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE9A_HUMAN
θ value	0 (rank : 1)	NC score	0.997194 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	93	Shared Neighborhood Hits	60
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE4B_HUMAN
θ value	1.41672e-45 (rank : 3)	NC score	0.924204 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4D_HUMAN
θ value	2.67181e-44 (rank : 4)	NC score	0.922355 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	122	Shared Neighborhood Hits	39
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
θ value	2.67181e-44 (rank : 5)	NC score	0.923069 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_HUMAN
θ value	7.77379e-44 (rank : 6)	NC score	0.922698 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
θ value	1.73182e-43 (rank : 7)	NC score	0.922923 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4C_HUMAN
θ value	1.91475e-42 (rank : 8)	NC score	0.925802 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE8A_HUMAN
θ value	9.50281e-42 (rank : 9)	NC score	0.919362 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE4C_MOUSE
θ value	1.62093e-41 (rank : 10)	NC score	0.927002 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE11_MOUSE
θ value	1.05066e-40 (rank : 11)	NC score	0.890492 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	39
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_HUMAN
θ value	2.34062e-40 (rank : 12)	NC score	0.890528 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE8A_MOUSE
θ value	5.21438e-40 (rank : 13)	NC score	0.915799 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	52	Shared Neighborhood Hits	40
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE7A_HUMAN
θ value	4.41421e-39 (rank : 14)	NC score	0.935508 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE8B_HUMAN
θ value	4.41421e-39 (rank : 15)	NC score	0.915944 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE2A_HUMAN
θ value	1.6774e-38 (rank : 16)	NC score	0.901562 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_MOUSE
θ value	1.6774e-38 (rank : 17)	NC score	0.902378 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE7B_HUMAN
θ value	1.6774e-38 (rank : 18)	NC score	0.932895 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_MOUSE
θ value	3.73686e-38 (rank : 19)	NC score	0.934719 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7B_MOUSE
θ value	6.37413e-38 (rank : 20)	NC score	0.933684 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	44	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE1B_MOUSE
θ value	4.13158e-37 (rank : 21)	NC score	0.920646 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	46	Shared Neighborhood Hits	39
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_MOUSE
θ value	7.04741e-37 (rank : 22)	NC score	0.918526 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1B_HUMAN
θ value	3.4976e-36 (rank : 23)	NC score	0.918136 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	40
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_HUMAN
θ value	5.96599e-36 (rank : 24)	NC score	0.916790 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1C_HUMAN
θ value	2.26708e-35 (rank : 25)	NC score	0.907003 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	4.27553e-34 (rank : 26)	NC score	0.905784 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE5A_HUMAN
θ value	1.52067e-31 (rank : 27)	NC score	0.869507 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_MOUSE
θ value	1.52067e-31 (rank : 28)	NC score	0.871677 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6B_MOUSE
θ value	1.85889e-29 (rank : 29)	NC score	0.845524 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_HUMAN
θ value	5.40856e-29 (rank : 30)	NC score	0.846765 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_HUMAN
θ value	1.57365e-28 (rank : 31)	NC score	0.848350 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE3A_HUMAN
θ value	2.05525e-28 (rank : 32)	NC score	0.878117 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3B_HUMAN
θ value	4.57862e-28 (rank : 33)	NC score	0.888910 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_MOUSE
θ value	7.80994e-28 (rank : 34)	NC score	0.876977 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE6C_MOUSE
θ value	7.80994e-28 (rank : 35)	NC score	0.852280 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
θ value	1.02001e-27 (rank : 36)	NC score	0.851321 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_MOUSE
θ value	3.28125e-26 (rank : 37)	NC score	0.843867 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE10_HUMAN
θ value	5.59698e-26 (rank : 38)	NC score	0.880106 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

SESN1_MOUSE
θ value	0.00390308 (rank : 39)	NC score	0.057115 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

PARC_HUMAN
θ value	0.0252991 (rank : 40)	NC score	0.040607 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

SESN1_HUMAN
θ value	0.0736092 (rank : 41)	NC score	0.048988 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6P5, Q9NV00, Q9UPD5, Q9Y6P6	Gene names	SESN1, PA26, SEST1
Domain Architecture
Description	Sestrin-1 (p53-regulated protein PA26).

MYH2_HUMAN
θ value	0.21417 (rank : 42)	NC score	0.022669 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	1491	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH8_MOUSE
θ value	0.21417 (rank : 43)	NC score	0.022061 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	1600	Shared Neighborhood Hits	27
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PARC_MOUSE
θ value	0.279714 (rank : 44)	NC score	0.034391 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

SMC4_HUMAN
θ value	0.365318 (rank : 45)	NC score	0.020964 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	937	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

CCD41_MOUSE
θ value	0.47712 (rank : 46)	NC score	0.015436 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	1399	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

MYH1_HUMAN
θ value	0.47712 (rank : 47)	NC score	0.022189 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	1478	Shared Neighborhood Hits	27
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	0.47712 (rank : 48)	NC score	0.022550 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	1461	Shared Neighborhood Hits	27
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

BRE1B_HUMAN
θ value	0.813845 (rank : 49)	NC score	0.021186 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	1040	Shared Neighborhood Hits	27
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	0.813845 (rank : 50)	NC score	0.022173 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	970	Shared Neighborhood Hits	27
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

MACF1_HUMAN
θ value	0.813845 (rank : 51)	NC score	0.015607 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	1341	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	0.813845 (rank : 52)	NC score	0.018228 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	1321	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

PSIP1_MOUSE
θ value	0.813845 (rank : 53)	NC score	0.021106 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

MYH8_HUMAN
θ value	1.06291 (rank : 54)	NC score	0.020667 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	1610	Shared Neighborhood Hits	28
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PSIP1_HUMAN
θ value	1.06291 (rank : 55)	NC score	0.019112 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	341	Shared Neighborhood Hits	4
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

K1C10_MOUSE
θ value	1.38821 (rank : 56)	NC score	0.007243 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	P02535, P08731, Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4	Gene names	Krt10, Krt1-10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) (56 kDa cytokeratin) (Keratin, type I cytoskeletal 59 kDa).

MYH4_MOUSE
θ value	1.81305 (rank : 57)	NC score	0.022355 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	1476	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

TMF1_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.018108 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	987	Shared Neighborhood Hits	26
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

EEA1_MOUSE
θ value	3.0926 (rank : 59)	NC score	0.011507 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	1637	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MYH4_HUMAN
θ value	3.0926 (rank : 60)	NC score	0.021660 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	1377	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

TRFL_MOUSE
θ value	3.0926 (rank : 61)	NC score	0.008293 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P08071, P70690, Q61799, Q922P2	Gene names	Ltf
Domain Architecture
Description	Lactotransferrin precursor (EC 3.4.21.-) (Lactoferrin).

CP2C8_HUMAN
θ value	4.03905 (rank : 62)	NC score	0.000774 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	P10632	Gene names	CYP2C8
Domain Architecture
Description	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase).

CE290_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.013111 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	1553	Shared Neighborhood Hits	27
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

K1C10_HUMAN
θ value	5.27518 (rank : 64)	NC score	0.006380 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	526	Shared Neighborhood Hits	23
SwissProt Accessions	P13645, Q14664, Q8N175	Gene names	KRT10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10).

PDCD7_MOUSE
θ value	5.27518 (rank : 65)	NC score	0.033928 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

SM1L2_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.014342 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	1019	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

BICD2_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.012272 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	856	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.012810 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	864	Shared Neighborhood Hits	24
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

MYH11_MOUSE
θ value	6.88961 (rank : 69)	NC score	0.017077 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	1777	Shared Neighborhood Hits	31
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH13_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.020407 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	1504	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PIBF1_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.010767 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	1041	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

SAMH1_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.006787 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

Hits sorted by NC score

PDE9A_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_HUMAN
NC score	0.997194 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	93	Shared Neighborhood Hits	60
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE7A_HUMAN
NC score	0.935508 (rank : 3)	θ value	4.41421e-39 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
NC score	0.934719 (rank : 4)	θ value	3.73686e-38 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7B_MOUSE
NC score	0.933684 (rank : 5)	θ value	6.37413e-38 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	44	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.932895 (rank : 6)	θ value	1.6774e-38 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE4C_MOUSE
NC score	0.927002 (rank : 7)	θ value	1.62093e-41 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4C_HUMAN
NC score	0.925802 (rank : 8)	θ value	1.91475e-42 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4B_HUMAN
NC score	0.924204 (rank : 9)	θ value	1.41672e-45 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4D_MOUSE
NC score	0.923069 (rank : 10)	θ value	2.67181e-44 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_MOUSE
NC score	0.922923 (rank : 11)	θ value	1.73182e-43 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4A_HUMAN
NC score	0.922698 (rank : 12)	θ value	7.77379e-44 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4D_HUMAN
NC score	0.922355 (rank : 13)	θ value	2.67181e-44 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	122	Shared Neighborhood Hits	39
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE1B_MOUSE
NC score	0.920646 (rank : 14)	θ value	4.13158e-37 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	46	Shared Neighborhood Hits	39
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8A_HUMAN
NC score	0.919362 (rank : 15)	θ value	9.50281e-42 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE1A_MOUSE
NC score	0.918526 (rank : 16)	θ value	7.04741e-37 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1B_HUMAN
NC score	0.918136 (rank : 17)	θ value	3.4976e-36 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	40
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.916790 (rank : 18)	θ value	5.96599e-36 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE8B_HUMAN
NC score	0.915944 (rank : 19)	θ value	4.41421e-39 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE8A_MOUSE
NC score	0.915799 (rank : 20)	θ value	5.21438e-40 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	52	Shared Neighborhood Hits	40
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE1C_HUMAN
NC score	0.907003 (rank : 21)	θ value	2.26708e-35 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.905784 (rank : 22)	θ value	4.27553e-34 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE2A_MOUSE
NC score	0.902378 (rank : 23)	θ value	1.6774e-38 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.901562 (rank : 24)	θ value	1.6774e-38 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.890528 (rank : 25)	θ value	2.34062e-40 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.890492 (rank : 26)	θ value	1.05066e-40 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	39
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE3B_HUMAN
NC score	0.888910 (rank : 27)	θ value	4.57862e-28 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE10_HUMAN
NC score	0.880106 (rank : 28)	θ value	5.59698e-26 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE3A_HUMAN
NC score	0.878117 (rank : 29)	θ value	2.05525e-28 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.876977 (rank : 30)	θ value	7.80994e-28 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE5A_MOUSE
NC score	0.871677 (rank : 31)	θ value	1.52067e-31 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.869507 (rank : 32)	θ value	1.52067e-31 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.852280 (rank : 33)	θ value	7.80994e-28 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.851321 (rank : 34)	θ value	1.02001e-27 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.848350 (rank : 35)	θ value	1.57365e-28 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6B_HUMAN
NC score	0.846765 (rank : 36)	θ value	5.40856e-29 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
NC score	0.845524 (rank : 37)	θ value	1.85889e-29 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_MOUSE
NC score	0.843867 (rank : 38)	θ value	3.28125e-26 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

SESN1_MOUSE
NC score	0.057115 (rank : 39)	θ value	0.00390308 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

SESN1_HUMAN
NC score	0.048988 (rank : 40)	θ value	0.0736092 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6P5, Q9NV00, Q9UPD5, Q9Y6P6	Gene names	SESN1, PA26, SEST1
Domain Architecture
Description	Sestrin-1 (p53-regulated protein PA26).

PARC_HUMAN
NC score	0.040607 (rank : 41)	θ value	0.0252991 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
NC score	0.034391 (rank : 42)	θ value	0.279714 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PDCD7_MOUSE
NC score	0.033928 (rank : 43)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

MYH2_HUMAN
NC score	0.022669 (rank : 44)	θ value	0.21417 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	1491	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH1_MOUSE
NC score	0.022550 (rank : 45)	θ value	0.47712 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	1461	Shared Neighborhood Hits	27
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH4_MOUSE
NC score	0.022355 (rank : 46)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	1476	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH1_HUMAN
NC score	0.022189 (rank : 47)	θ value	0.47712 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	1478	Shared Neighborhood Hits	27
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

BRE1B_MOUSE
NC score	0.022173 (rank : 48)	θ value	0.813845 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	970	Shared Neighborhood Hits	27
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

MYH8_MOUSE
NC score	0.022061 (rank : 49)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	1600	Shared Neighborhood Hits	27
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH4_HUMAN
NC score	0.021660 (rank : 50)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	1377	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

BRE1B_HUMAN
NC score	0.021186 (rank : 51)	θ value	0.813845 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	1040	Shared Neighborhood Hits	27
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

PSIP1_MOUSE
NC score	0.021106 (rank : 52)	θ value	0.813845 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

SMC4_HUMAN
NC score	0.020964 (rank : 53)	θ value	0.365318 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	937	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

MYH8_HUMAN
NC score	0.020667 (rank : 54)	θ value	1.06291 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	1610	Shared Neighborhood Hits	28
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH13_HUMAN
NC score	0.020407 (rank : 55)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	1504	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PSIP1_HUMAN
NC score	0.019112 (rank : 56)	θ value	1.06291 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	341	Shared Neighborhood Hits	4
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

MACF4_HUMAN
NC score	0.018228 (rank : 57)	θ value	0.813845 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	1321	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

TMF1_HUMAN
NC score	0.018108 (rank : 58)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	987	Shared Neighborhood Hits	26
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

MYH11_MOUSE
NC score	0.017077 (rank : 59)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	1777	Shared Neighborhood Hits	31
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MACF1_HUMAN
NC score	0.015607 (rank : 60)	θ value	0.813845 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	1341	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

CCD41_MOUSE
NC score	0.015436 (rank : 61)	θ value	0.47712 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	1399	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

SM1L2_HUMAN
NC score	0.014342 (rank : 62)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	1019	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

CE290_HUMAN
NC score	0.013111 (rank : 63)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	1553	Shared Neighborhood Hits	27
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

BICD2_MOUSE
NC score	0.012810 (rank : 64)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	864	Shared Neighborhood Hits	24
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_HUMAN
NC score	0.012272 (rank : 65)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	856	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

EEA1_MOUSE
NC score	0.011507 (rank : 66)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	1637	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

PIBF1_HUMAN
NC score	0.010767 (rank : 67)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	1041	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

TRFL_MOUSE
NC score	0.008293 (rank : 68)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P08071, P70690, Q61799, Q922P2	Gene names	Ltf
Domain Architecture
Description	Lactotransferrin precursor (EC 3.4.21.-) (Lactoferrin).

K1C10_MOUSE
NC score	0.007243 (rank : 69)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	P02535, P08731, Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4	Gene names	Krt10, Krt1-10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) (56 kDa cytokeratin) (Keratin, type I cytoskeletal 59 kDa).

SAMH1_HUMAN
NC score	0.006787 (rank : 70)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

K1C10_HUMAN
NC score	0.006380 (rank : 71)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	526	Shared Neighborhood Hits	23
SwissProt Accessions	P13645, Q14664, Q8N175	Gene names	KRT10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10).

CP2C8_HUMAN
NC score	0.000774 (rank : 72)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	P10632	Gene names	CYP2C8
Domain Architecture
Description	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase).