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Network neighborhood for query Sequence : PDE8B_HUMAN

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PDE8B_HUMAN
 
SwissProt Accessions O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2 Gene names PDE8B
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).
Rank Plots


Hits sorted by θ


PDE8A_HUMAN
 
θ value 0 (rank : 1) NC score 0.997486 (rank : 2)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7 Gene names PDE8A
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).
PDE8A_MOUSE
 
θ value 0 (rank : 2) NC score 0.997028 (rank : 3)
Query Neighborhood Hits 47 Target Neighborhood Hits 52 Shared Neighborhood Hits 38
SwissProt Accessions O88502 Gene names Pde8a, Pde8
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).
PDE8B_HUMAN
 
θ value 0 (rank : 3) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 47
SwissProt Accessions O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2 Gene names PDE8B
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).
PDE4B_HUMAN
 
θ value 3.0428e-56 (rank : 4) NC score 0.924870 (rank : 8)
Query Neighborhood Hits 47 Target Neighborhood Hits 65 Shared Neighborhood Hits 38
SwissProt Accessions Q07343, O15443 Gene names PDE4B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).
PDE4A_MOUSE
 
θ value 1.2784e-54 (rank : 5) NC score 0.921651 (rank : 9)
Query Neighborhood Hits 47 Target Neighborhood Hits 66 Shared Neighborhood Hits 38
SwissProt Accessions O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8 Gene names Pde4a
Domain
Architecture
Description cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).
PDE4A_HUMAN
 
θ value 1.66964e-54 (rank : 6) NC score 0.921080 (rank : 13)
Query Neighborhood Hits 47 Target Neighborhood Hits 73 Shared Neighborhood Hits 38
SwissProt Accessions P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3 Gene names PDE4A
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).
PDE4C_MOUSE
 
θ value 1.66964e-54 (rank : 7) NC score 0.926968 (rank : 5)
Query Neighborhood Hits 47 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q3UEI1, Q8K0P4 Gene names Pde4c
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).
PDE4C_HUMAN
 
θ value 6.34462e-54 (rank : 8) NC score 0.924949 (rank : 7)
Query Neighborhood Hits 47 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6 Gene names PDE4C
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).
PDE4D_HUMAN
 
θ value 1.41344e-53 (rank : 9) NC score 0.920576 (rank : 14)
Query Neighborhood Hits 47 Target Neighborhood Hits 122 Shared Neighborhood Hits 38
SwissProt Accessions Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7 Gene names PDE4D
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).
PDE4D_MOUSE
 
θ value 1.41344e-53 (rank : 10) NC score 0.921251 (rank : 12)
Query Neighborhood Hits 47 Target Neighborhood Hits 98 Shared Neighborhood Hits 38
SwissProt Accessions Q01063, Q6TRH9, Q8C4Q7, Q8CG05 Gene names Pde4d
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).
PDE7A_HUMAN
 
θ value 7.03111e-45 (rank : 11) NC score 0.927573 (rank : 4)
Query Neighborhood Hits 47 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions Q13946, O15380 Gene names PDE7A
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).
PDE7A_MOUSE
 
θ value 1.56636e-44 (rank : 12) NC score 0.926674 (rank : 6)
Query Neighborhood Hits 47 Target Neighborhood Hits 39 Shared Neighborhood Hits 38
SwissProt Accessions P70453, Q9ERB3 Gene names Pde7a
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).
PDE1C_MOUSE
 
θ value 4.2656e-42 (rank : 13) NC score 0.901718 (rank : 22)
Query Neighborhood Hits 47 Target Neighborhood Hits 161 Shared Neighborhood Hits 38
SwissProt Accessions Q64338, Q62045, Q8BSV6 Gene names Pde1c
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).
PDE1C_HUMAN
 
θ value 7.27602e-42 (rank : 14) NC score 0.902227 (rank : 21)
Query Neighborhood Hits 47 Target Neighborhood Hits 134 Shared Neighborhood Hits 38
SwissProt Accessions Q14123, Q14124 Gene names PDE1C
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).
PDE1A_MOUSE
 
θ value 1.62093e-41 (rank : 15) NC score 0.911898 (rank : 17)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions Q61481, O35388 Gene names Pde1a
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).
PDE1A_HUMAN
 
θ value 2.34062e-40 (rank : 16) NC score 0.910540 (rank : 18)
Query Neighborhood Hits 47 Target Neighborhood Hits 42 Shared Neighborhood Hits 38
SwissProt Accessions P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3 Gene names PDE1A
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).
PDE9A_HUMAN
 
θ value 2.34062e-40 (rank : 17) NC score 0.913086 (rank : 16)
Query Neighborhood Hits 47 Target Neighborhood Hits 93 Shared Neighborhood Hits 38
SwissProt Accessions O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0 Gene names PDE9A
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE7B_HUMAN
 
θ value 3.99248e-40 (rank : 18) NC score 0.921492 (rank : 11)
Query Neighborhood Hits 47 Target Neighborhood Hits 43 Shared Neighborhood Hits 38
SwissProt Accessions Q9NP56 Gene names PDE7B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE7B_MOUSE
 
θ value 5.21438e-40 (rank : 19) NC score 0.921643 (rank : 10)
Query Neighborhood Hits 47 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions Q9QXQ1 Gene names Pde7b
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE9A_MOUSE
 
θ value 4.41421e-39 (rank : 20) NC score 0.915944 (rank : 15)
Query Neighborhood Hits 47 Target Neighborhood Hits 72 Shared Neighborhood Hits 38
SwissProt Accessions O70628 Gene names Pde9a, Pde8b
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE1B_MOUSE
 
θ value 1.42001e-37 (rank : 21) NC score 0.910196 (rank : 19)
Query Neighborhood Hits 47 Target Neighborhood Hits 46 Shared Neighborhood Hits 38
SwissProt Accessions Q01065, O35384 Gene names Pde1b, Pde1b1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE3A_MOUSE
 
θ value 2.05049e-36 (rank : 22) NC score 0.886102 (rank : 25)
Query Neighborhood Hits 47 Target Neighborhood Hits 115 Shared Neighborhood Hits 38
SwissProt Accessions Q9Z0X4 Gene names Pde3a
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE1B_HUMAN
 
θ value 3.4976e-36 (rank : 23) NC score 0.907566 (rank : 20)
Query Neighborhood Hits 47 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions Q01064, Q92825 Gene names PDE1B, PDE1B1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE3A_HUMAN
 
θ value 3.4976e-36 (rank : 24) NC score 0.888103 (rank : 24)
Query Neighborhood Hits 47 Target Neighborhood Hits 79 Shared Neighborhood Hits 38
SwissProt Accessions Q14432, O60865, Q13348 Gene names PDE3A
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE3B_HUMAN
 
θ value 5.96599e-36 (rank : 25) NC score 0.898924 (rank : 23)
Query Neighborhood Hits 47 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q13370, O00639, Q14408 Gene names PDE3B
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).
PDE11_HUMAN
 
θ value 3.62785e-25 (rank : 26) NC score 0.808311 (rank : 28)
Query Neighborhood Hits 47 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45 Gene names PDE11A
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE11_MOUSE
 
θ value 4.01107e-24 (rank : 27) NC score 0.806912 (rank : 29)
Query Neighborhood Hits 47 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions P0C1Q2 Gene names Pde11a
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE6C_HUMAN
 
θ value 5.79196e-23 (rank : 28) NC score 0.777284 (rank : 34)
Query Neighborhood Hits 47 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions P51160, Q5VY29 Gene names PDE6C, PDEA2
Domain
Architecture
Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE6C_MOUSE
 
θ value 1.6852e-22 (rank : 29) NC score 0.778009 (rank : 32)
Query Neighborhood Hits 47 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions Q91ZQ1, Q8R0D4 Gene names Pde6c
Domain
Architecture

No domain graphic available

Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE2A_MOUSE
 
θ value 2.69047e-20 (rank : 30) NC score 0.817105 (rank : 26)
Query Neighborhood Hits 47 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q922S4, Q8K2U1 Gene names Pde2a
Domain
Architecture

No domain graphic available

Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE2A_HUMAN
 
θ value 3.51386e-20 (rank : 31) NC score 0.816134 (rank : 27)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O00408 Gene names PDE2A
Domain
Architecture
Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE6A_HUMAN
 
θ value 7.82807e-20 (rank : 32) NC score 0.769462 (rank : 35)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions P16499 Gene names PDE6A, PDEA
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).
PDE6A_MOUSE
 
θ value 1.02238e-19 (rank : 33) NC score 0.765707 (rank : 36)
Query Neighborhood Hits 47 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions P27664 Gene names Pde6a, Mpa, Pdea
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).
PDE6B_MOUSE
 
θ value 1.74391e-19 (rank : 34) NC score 0.764061 (rank : 38)
Query Neighborhood Hits 47 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions P23440 Gene names Pde6b, Mpb, Pdeb, rd
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).
PDE6B_HUMAN
 
θ value 8.65492e-19 (rank : 35) NC score 0.765486 (rank : 37)
Query Neighborhood Hits 47 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions P35913, Q9BWH5 Gene names PDE6B, PDEB
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).
PDE5A_MOUSE
 
θ value 2.7842e-17 (rank : 36) NC score 0.782015 (rank : 30)
Query Neighborhood Hits 47 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions Q8CG03 Gene names Pde5a, Pde5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
PDE5A_HUMAN
 
θ value 6.20254e-17 (rank : 37) NC score 0.777633 (rank : 33)
Query Neighborhood Hits 47 Target Neighborhood Hits 48 Shared Neighborhood Hits 38
SwissProt Accessions O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6 Gene names PDE5A, PDE5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
PDE10_HUMAN
 
θ value 1.133e-10 (rank : 38) NC score 0.780637 (rank : 31)
Query Neighborhood Hits 47 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q9Y233, Q9Y5T1 Gene names PDE10A
Domain
Architecture
Description cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).
M3K1_MOUSE
 
θ value 0.62314 (rank : 39) NC score -0.002071 (rank : 46)
Query Neighborhood Hits 47 Target Neighborhood Hits 952 Shared Neighborhood Hits 2
SwissProt Accessions P53349, Q60831, Q9R0U3, Q9R256 Gene names Map3k1, Mekk, Mekk1
Domain
Architecture
Description Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).
SYNJ1_HUMAN
 
θ value 2.36792 (rank : 40) NC score 0.005825 (rank : 41)
Query Neighborhood Hits 47 Target Neighborhood Hits 498 Shared Neighborhood Hits 2
SwissProt Accessions O43426, O43425, O94984 Gene names SYNJ1, KIAA0910
Domain
Architecture
Description Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).
AMBP_HUMAN
 
θ value 5.27518 (rank : 41) NC score 0.007055 (rank : 39)
Query Neighborhood Hits 47 Target Neighborhood Hits 46 Shared Neighborhood Hits 2
SwissProt Accessions P02760, P00977, P02759 Gene names AMBP, HCP, ITIL
Domain
Architecture
Description AMBP protein precursor [Contains: Alpha-1-microglobulin (Protein HC) (Complex-forming glycoprotein heterogeneous in charge) (Alpha-1 microglycoprotein); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].
AP4E1_MOUSE
 
θ value 5.27518 (rank : 42) NC score 0.005865 (rank : 40)
Query Neighborhood Hits 47 Target Neighborhood Hits 59 Shared Neighborhood Hits 2
SwissProt Accessions Q80V94 Gene names Ap4e1
Domain
Architecture

No domain graphic available

Description AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).
FBXW7_HUMAN
 
θ value 5.27518 (rank : 43) NC score 0.001302 (rank : 44)
Query Neighborhood Hits 47 Target Neighborhood Hits 433 Shared Neighborhood Hits 3
SwissProt Accessions Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6 Gene names FBXW7, FBW7, FBX30, SEL10
Domain
Architecture
Description F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).
FBXW7_MOUSE
 
θ value 5.27518 (rank : 44) NC score 0.001443 (rank : 43)
Query Neighborhood Hits 47 Target Neighborhood Hits 365 Shared Neighborhood Hits 3
SwissProt Accessions Q8VBV4, Q8CCS5, Q8VHP4 Gene names Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain
Architecture
Description F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).
LTBP4_MOUSE
 
θ value 5.27518 (rank : 45) NC score -0.000772 (rank : 45)
Query Neighborhood Hits 47 Target Neighborhood Hits 607 Shared Neighborhood Hits 2
SwissProt Accessions Q8K4G1, Q8K4G0 Gene names Ltbp4
Domain
Architecture
Description Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).
PDZD3_HUMAN
 
θ value 5.27518 (rank : 46) NC score 0.004171 (rank : 42)
Query Neighborhood Hits 47 Target Neighborhood Hits 180 Shared Neighborhood Hits 2
SwissProt Accessions Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3 Gene names PDZD3, IKEPP, PDZK2
Domain
Architecture

No domain graphic available

Description PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).
ZN418_HUMAN
 
θ value 6.88961 (rank : 47) NC score -0.004678 (rank : 47)
Query Neighborhood Hits 47 Target Neighborhood Hits 776 Shared Neighborhood Hits 2
SwissProt Accessions Q8TF45, Q670L5, Q96N18 Gene names ZNF418, KIAA1956
Domain
Architecture
Description Zinc finger protein 418.

Hits sorted by NC score


PDE8B_HUMAN
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 3)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 47
SwissProt Accessions O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2 Gene names PDE8B
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).
PDE8A_HUMAN
 
NC score 0.997486 (rank : 2) θ value 0 (rank : 1)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7 Gene names PDE8A
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).
PDE8A_MOUSE
 
NC score 0.997028 (rank : 3) θ value 0 (rank : 2)
Query Neighborhood Hits 47 Target Neighborhood Hits 52 Shared Neighborhood Hits 38
SwissProt Accessions O88502 Gene names Pde8a, Pde8
Domain
Architecture
Description High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).
PDE7A_HUMAN
 
NC score 0.927573 (rank : 4) θ value 7.03111e-45 (rank : 11)
Query Neighborhood Hits 47 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions Q13946, O15380 Gene names PDE7A
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).
PDE4C_MOUSE
 
NC score 0.926968 (rank : 5) θ value 1.66964e-54 (rank : 7)
Query Neighborhood Hits 47 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q3UEI1, Q8K0P4 Gene names Pde4c
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).
PDE7A_MOUSE
 
NC score 0.926674 (rank : 6) θ value 1.56636e-44 (rank : 12)
Query Neighborhood Hits 47 Target Neighborhood Hits 39 Shared Neighborhood Hits 38
SwissProt Accessions P70453, Q9ERB3 Gene names Pde7a
Domain
Architecture
Description High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).
PDE4C_HUMAN
 
NC score 0.924949 (rank : 7) θ value 6.34462e-54 (rank : 8)
Query Neighborhood Hits 47 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6 Gene names PDE4C
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).
PDE4B_HUMAN
 
NC score 0.924870 (rank : 8) θ value 3.0428e-56 (rank : 4)
Query Neighborhood Hits 47 Target Neighborhood Hits 65 Shared Neighborhood Hits 38
SwissProt Accessions Q07343, O15443 Gene names PDE4B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).
PDE4A_MOUSE
 
NC score 0.921651 (rank : 9) θ value 1.2784e-54 (rank : 5)
Query Neighborhood Hits 47 Target Neighborhood Hits 66 Shared Neighborhood Hits 38
SwissProt Accessions O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8 Gene names Pde4a
Domain
Architecture
Description cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).
PDE7B_MOUSE
 
NC score 0.921643 (rank : 10) θ value 5.21438e-40 (rank : 19)
Query Neighborhood Hits 47 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions Q9QXQ1 Gene names Pde7b
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE7B_HUMAN
 
NC score 0.921492 (rank : 11) θ value 3.99248e-40 (rank : 18)
Query Neighborhood Hits 47 Target Neighborhood Hits 43 Shared Neighborhood Hits 38
SwissProt Accessions Q9NP56 Gene names PDE7B
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).
PDE4D_MOUSE
 
NC score 0.921251 (rank : 12) θ value 1.41344e-53 (rank : 10)
Query Neighborhood Hits 47 Target Neighborhood Hits 98 Shared Neighborhood Hits 38
SwissProt Accessions Q01063, Q6TRH9, Q8C4Q7, Q8CG05 Gene names Pde4d
Domain
Architecture

No domain graphic available

Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).
PDE4A_HUMAN
 
NC score 0.921080 (rank : 13) θ value 1.66964e-54 (rank : 6)
Query Neighborhood Hits 47 Target Neighborhood Hits 73 Shared Neighborhood Hits 38
SwissProt Accessions P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3 Gene names PDE4A
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).
PDE4D_HUMAN
 
NC score 0.920576 (rank : 14) θ value 1.41344e-53 (rank : 9)
Query Neighborhood Hits 47 Target Neighborhood Hits 122 Shared Neighborhood Hits 38
SwissProt Accessions Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7 Gene names PDE4D
Domain
Architecture
Description cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).
PDE9A_MOUSE
 
NC score 0.915944 (rank : 15) θ value 4.41421e-39 (rank : 20)
Query Neighborhood Hits 47 Target Neighborhood Hits 72 Shared Neighborhood Hits 38
SwissProt Accessions O70628 Gene names Pde9a, Pde8b
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE9A_HUMAN
 
NC score 0.913086 (rank : 16) θ value 2.34062e-40 (rank : 17)
Query Neighborhood Hits 47 Target Neighborhood Hits 93 Shared Neighborhood Hits 38
SwissProt Accessions O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0 Gene names PDE9A
Domain
Architecture
Description High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
PDE1A_MOUSE
 
NC score 0.911898 (rank : 17) θ value 1.62093e-41 (rank : 15)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions Q61481, O35388 Gene names Pde1a
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).
PDE1A_HUMAN
 
NC score 0.910540 (rank : 18) θ value 2.34062e-40 (rank : 16)
Query Neighborhood Hits 47 Target Neighborhood Hits 42 Shared Neighborhood Hits 38
SwissProt Accessions P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3 Gene names PDE1A
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).
PDE1B_MOUSE
 
NC score 0.910196 (rank : 19) θ value 1.42001e-37 (rank : 21)
Query Neighborhood Hits 47 Target Neighborhood Hits 46 Shared Neighborhood Hits 38
SwissProt Accessions Q01065, O35384 Gene names Pde1b, Pde1b1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE1B_HUMAN
 
NC score 0.907566 (rank : 20) θ value 3.4976e-36 (rank : 23)
Query Neighborhood Hits 47 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions Q01064, Q92825 Gene names PDE1B, PDE1B1
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).
PDE1C_HUMAN
 
NC score 0.902227 (rank : 21) θ value 7.27602e-42 (rank : 14)
Query Neighborhood Hits 47 Target Neighborhood Hits 134 Shared Neighborhood Hits 38
SwissProt Accessions Q14123, Q14124 Gene names PDE1C
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).
PDE1C_MOUSE
 
NC score 0.901718 (rank : 22) θ value 4.2656e-42 (rank : 13)
Query Neighborhood Hits 47 Target Neighborhood Hits 161 Shared Neighborhood Hits 38
SwissProt Accessions Q64338, Q62045, Q8BSV6 Gene names Pde1c
Domain
Architecture
Description Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).
PDE3B_HUMAN
 
NC score 0.898924 (rank : 23) θ value 5.96599e-36 (rank : 25)
Query Neighborhood Hits 47 Target Neighborhood Hits 60 Shared Neighborhood Hits 38
SwissProt Accessions Q13370, O00639, Q14408 Gene names PDE3B
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).
PDE3A_HUMAN
 
NC score 0.888103 (rank : 24) θ value 3.4976e-36 (rank : 24)
Query Neighborhood Hits 47 Target Neighborhood Hits 79 Shared Neighborhood Hits 38
SwissProt Accessions Q14432, O60865, Q13348 Gene names PDE3A
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE3A_MOUSE
 
NC score 0.886102 (rank : 25) θ value 2.05049e-36 (rank : 22)
Query Neighborhood Hits 47 Target Neighborhood Hits 115 Shared Neighborhood Hits 38
SwissProt Accessions Q9Z0X4 Gene names Pde3a
Domain
Architecture
Description cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
PDE2A_MOUSE
 
NC score 0.817105 (rank : 26) θ value 2.69047e-20 (rank : 30)
Query Neighborhood Hits 47 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q922S4, Q8K2U1 Gene names Pde2a
Domain
Architecture

No domain graphic available

Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE2A_HUMAN
 
NC score 0.816134 (rank : 27) θ value 3.51386e-20 (rank : 31)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions O00408 Gene names PDE2A
Domain
Architecture
Description cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).
PDE11_HUMAN
 
NC score 0.808311 (rank : 28) θ value 3.62785e-25 (rank : 26)
Query Neighborhood Hits 47 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45 Gene names PDE11A
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE11_MOUSE
 
NC score 0.806912 (rank : 29) θ value 4.01107e-24 (rank : 27)
Query Neighborhood Hits 47 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions P0C1Q2 Gene names Pde11a
Domain
Architecture

No domain graphic available

Description Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).
PDE5A_MOUSE
 
NC score 0.782015 (rank : 30) θ value 2.7842e-17 (rank : 36)
Query Neighborhood Hits 47 Target Neighborhood Hits 50 Shared Neighborhood Hits 38
SwissProt Accessions Q8CG03 Gene names Pde5a, Pde5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
PDE10_HUMAN
 
NC score 0.780637 (rank : 31) θ value 1.133e-10 (rank : 38)
Query Neighborhood Hits 47 Target Neighborhood Hits 49 Shared Neighborhood Hits 38
SwissProt Accessions Q9Y233, Q9Y5T1 Gene names PDE10A
Domain
Architecture
Description cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).
PDE6C_MOUSE
 
NC score 0.778009 (rank : 32) θ value 1.6852e-22 (rank : 29)
Query Neighborhood Hits 47 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions Q91ZQ1, Q8R0D4 Gene names Pde6c
Domain
Architecture

No domain graphic available

Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE5A_HUMAN
 
NC score 0.777633 (rank : 33) θ value 6.20254e-17 (rank : 37)
Query Neighborhood Hits 47 Target Neighborhood Hits 48 Shared Neighborhood Hits 38
SwissProt Accessions O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6 Gene names PDE5A, PDE5
Domain
Architecture
Description cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).
PDE6C_HUMAN
 
NC score 0.777284 (rank : 34) θ value 5.79196e-23 (rank : 28)
Query Neighborhood Hits 47 Target Neighborhood Hits 56 Shared Neighborhood Hits 38
SwissProt Accessions P51160, Q5VY29 Gene names PDE6C, PDEA2
Domain
Architecture
Description Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).
PDE6A_HUMAN
 
NC score 0.769462 (rank : 35) θ value 7.82807e-20 (rank : 32)
Query Neighborhood Hits 47 Target Neighborhood Hits 47 Shared Neighborhood Hits 38
SwissProt Accessions P16499 Gene names PDE6A, PDEA
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).
PDE6A_MOUSE
 
NC score 0.765707 (rank : 36) θ value 1.02238e-19 (rank : 33)
Query Neighborhood Hits 47 Target Neighborhood Hits 45 Shared Neighborhood Hits 38
SwissProt Accessions P27664 Gene names Pde6a, Mpa, Pdea
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).
PDE6B_HUMAN
 
NC score 0.765486 (rank : 37) θ value 8.65492e-19 (rank : 35)
Query Neighborhood Hits 47 Target Neighborhood Hits 44 Shared Neighborhood Hits 38
SwissProt Accessions P35913, Q9BWH5 Gene names PDE6B, PDEB
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).
PDE6B_MOUSE
 
NC score 0.764061 (rank : 38) θ value 1.74391e-19 (rank : 34)
Query Neighborhood Hits 47 Target Neighborhood Hits 41 Shared Neighborhood Hits 38
SwissProt Accessions P23440 Gene names Pde6b, Mpb, Pdeb, rd
Domain
Architecture
Description Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).
AMBP_HUMAN
 
NC score 0.007055 (rank : 39) θ value 5.27518 (rank : 41)
Query Neighborhood Hits 47 Target Neighborhood Hits 46 Shared Neighborhood Hits 2
SwissProt Accessions P02760, P00977, P02759 Gene names AMBP, HCP, ITIL
Domain
Architecture
Description AMBP protein precursor [Contains: Alpha-1-microglobulin (Protein HC) (Complex-forming glycoprotein heterogeneous in charge) (Alpha-1 microglycoprotein); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].
AP4E1_MOUSE
 
NC score 0.005865 (rank : 40) θ value 5.27518 (rank : 42)
Query Neighborhood Hits 47 Target Neighborhood Hits 59 Shared Neighborhood Hits 2
SwissProt Accessions Q80V94 Gene names Ap4e1
Domain
Architecture

No domain graphic available

Description AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 epsilon-1 subunit) (Epsilon subunit of AP-4) (AP-4 adapter complex epsilon subunit).
SYNJ1_HUMAN
 
NC score 0.005825 (rank : 41) θ value 2.36792 (rank : 40)
Query Neighborhood Hits 47 Target Neighborhood Hits 498 Shared Neighborhood Hits 2
SwissProt Accessions O43426, O43425, O94984 Gene names SYNJ1, KIAA0910
Domain
Architecture
Description Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).
PDZD3_HUMAN
 
NC score 0.004171 (rank : 42) θ value 5.27518 (rank : 46)
Query Neighborhood Hits 47 Target Neighborhood Hits 180 Shared Neighborhood Hits 2
SwissProt Accessions Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3 Gene names PDZD3, IKEPP, PDZK2
Domain
Architecture

No domain graphic available

Description PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).
FBXW7_MOUSE
 
NC score 0.001443 (rank : 43) θ value 5.27518 (rank : 44)
Query Neighborhood Hits 47 Target Neighborhood Hits 365 Shared Neighborhood Hits 3
SwissProt Accessions Q8VBV4, Q8CCS5, Q8VHP4 Gene names Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain
Architecture
Description F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).
FBXW7_HUMAN
 
NC score 0.001302 (rank : 44) θ value 5.27518 (rank : 43)
Query Neighborhood Hits 47 Target Neighborhood Hits 433 Shared Neighborhood Hits 3
SwissProt Accessions Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6 Gene names FBXW7, FBW7, FBX30, SEL10
Domain
Architecture
Description F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).
LTBP4_MOUSE
 
NC score -0.000772 (rank : 45) θ value 5.27518 (rank : 45)
Query Neighborhood Hits 47 Target Neighborhood Hits 607 Shared Neighborhood Hits 2
SwissProt Accessions Q8K4G1, Q8K4G0 Gene names Ltbp4
Domain
Architecture
Description Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).
M3K1_MOUSE
 
NC score -0.002071 (rank : 46) θ value 0.62314 (rank : 39)
Query Neighborhood Hits 47 Target Neighborhood Hits 952 Shared Neighborhood Hits 2
SwissProt Accessions P53349, Q60831, Q9R0U3, Q9R256 Gene names Map3k1, Mekk, Mekk1
Domain
Architecture
Description Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).
ZN418_HUMAN
 
NC score -0.004678 (rank : 47) θ value 6.88961 (rank : 47)
Query Neighborhood Hits 47 Target Neighborhood Hits 776 Shared Neighborhood Hits 2
SwissProt Accessions Q8TF45, Q670L5, Q96N18 Gene names ZNF418, KIAA1956
Domain
Architecture
Description Zinc finger protein 418.