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Network neighborhood for query Sequence : PDE9A_HUMAN

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PDE9A_HUMAN
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE9A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
θ value	0 (rank : 2)	NC score	0.997194 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	72	Shared Neighborhood Hits	60
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE4D_MOUSE
θ value	2.04573e-44 (rank : 3)	NC score	0.919695 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4B_HUMAN
θ value	2.67181e-44 (rank : 4)	NC score	0.920494 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4D_HUMAN
θ value	2.67181e-44 (rank : 5)	NC score	0.919051 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	122	Shared Neighborhood Hits	41
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4A_HUMAN
θ value	3.48949e-44 (rank : 6)	NC score	0.919377 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
θ value	3.48949e-44 (rank : 7)	NC score	0.919635 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE8A_HUMAN
θ value	1.46607e-42 (rank : 8)	NC score	0.916591 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE4C_HUMAN
θ value	2.50074e-42 (rank : 9)	NC score	0.922384 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
θ value	8.04462e-41 (rank : 10)	NC score	0.923592 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE8B_HUMAN
θ value	2.34062e-40 (rank : 11)	NC score	0.913086 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE11_MOUSE
θ value	8.89434e-40 (rank : 12)	NC score	0.889898 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	39
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE8A_MOUSE
θ value	1.98146e-39 (rank : 13)	NC score	0.912621 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE11_HUMAN
θ value	3.37985e-39 (rank : 14)	NC score	0.889931 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE7A_HUMAN
θ value	1.28434e-38 (rank : 15)	NC score	0.931451 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
θ value	3.73686e-38 (rank : 16)	NC score	0.930596 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE2A_HUMAN
θ value	4.88048e-38 (rank : 17)	NC score	0.900231 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_MOUSE
θ value	4.88048e-38 (rank : 18)	NC score	0.901064 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE1B_MOUSE
θ value	2.42216e-37 (rank : 19)	NC score	0.917216 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	46	Shared Neighborhood Hits	39
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE7B_MOUSE
θ value	9.20422e-37 (rank : 20)	NC score	0.929270 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE1B_HUMAN
θ value	1.20211e-36 (rank : 21)	NC score	0.914837 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	41
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_MOUSE
θ value	1.57e-36 (rank : 22)	NC score	0.915018 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE7B_HUMAN
θ value	3.4976e-36 (rank : 23)	NC score	0.928468 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE1A_HUMAN
θ value	1.32909e-35 (rank : 24)	NC score	0.913256 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1C_HUMAN
θ value	6.59618e-35 (rank : 25)	NC score	0.903547 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	3.27365e-34 (rank : 26)	NC score	0.902329 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE5A_MOUSE
θ value	2.34606e-32 (rank : 27)	NC score	0.871769 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
θ value	3.06405e-32 (rank : 28)	NC score	0.869579 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6B_MOUSE
θ value	1.16434e-31 (rank : 29)	NC score	0.847671 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_HUMAN
θ value	1.28732e-30 (rank : 30)	NC score	0.850441 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6B_HUMAN
θ value	1.28732e-30 (rank : 31)	NC score	0.848812 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6C_HUMAN
θ value	1.08979e-29 (rank : 32)	NC score	0.853302 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_MOUSE
θ value	2.42779e-29 (rank : 33)	NC score	0.854186 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE3A_HUMAN
θ value	1.57365e-28 (rank : 34)	NC score	0.874453 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE6A_MOUSE
θ value	3.50572e-28 (rank : 35)	NC score	0.846012 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE3A_MOUSE
θ value	7.80994e-28 (rank : 36)	NC score	0.873256 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3B_HUMAN
θ value	2.96777e-27 (rank : 37)	NC score	0.884607 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE10_HUMAN
θ value	6.61148e-27 (rank : 38)	NC score	0.879796 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

SESN1_MOUSE
θ value	0.00134147 (rank : 39)	NC score	0.061199 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

SESN1_HUMAN
θ value	0.0148317 (rank : 40)	NC score	0.053079 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6P5, Q9NV00, Q9UPD5, Q9Y6P6	Gene names	SESN1, PA26, SEST1
Domain Architecture
Description	Sestrin-1 (p53-regulated protein PA26).

PDCD7_MOUSE
θ value	0.0330416 (rank : 41)	NC score	0.054919 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	214	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

MYH2_HUMAN
θ value	0.0431538 (rank : 42)	NC score	0.039144 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	1491	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH8_MOUSE
θ value	0.0563607 (rank : 43)	NC score	0.038204 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	1600	Shared Neighborhood Hits	45
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH1_HUMAN
θ value	0.0736092 (rank : 44)	NC score	0.038709 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	1478	Shared Neighborhood Hits	45
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	0.0736092 (rank : 45)	NC score	0.038961 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	1461	Shared Neighborhood Hits	45
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

PARC_HUMAN
θ value	0.0736092 (rank : 46)	NC score	0.037135 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

MYH4_MOUSE
θ value	0.279714 (rank : 47)	NC score	0.038377 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	1476	Shared Neighborhood Hits	45
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH8_HUMAN
θ value	0.279714 (rank : 48)	NC score	0.036697 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	1610	Shared Neighborhood Hits	46
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

CING_HUMAN
θ value	0.47712 (rank : 49)	NC score	0.028873 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	1275	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

RADI_HUMAN
θ value	0.47712 (rank : 50)	NC score	0.016916 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	741	Shared Neighborhood Hits	41
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

CCD41_MOUSE
θ value	0.62314 (rank : 51)	NC score	0.024103 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	1399	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

MYH4_HUMAN
θ value	0.62314 (rank : 52)	NC score	0.037698 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	1377	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

PARC_MOUSE
θ value	0.62314 (rank : 53)	NC score	0.030997 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

SPEG_MOUSE
θ value	0.813845 (rank : 54)	NC score	-0.004046 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	1959	Shared Neighborhood Hits	5
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CENPF_HUMAN
θ value	1.38821 (rank : 55)	NC score	0.021983 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	1932	Shared Neighborhood Hits	43
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CING_MOUSE
θ value	1.81305 (rank : 56)	NC score	0.025808 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	1432	Shared Neighborhood Hits	44
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

MYH13_HUMAN
θ value	1.81305 (rank : 57)	NC score	0.036120 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	1504	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PDCD7_HUMAN
θ value	2.36792 (rank : 58)	NC score	0.033366 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	255	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

TMF1_HUMAN
θ value	2.36792 (rank : 59)	NC score	0.025413 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	987	Shared Neighborhood Hits	40
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

JPH3_MOUSE
θ value	3.0926 (rank : 60)	NC score	0.007104 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ET77, Q9EQZ2	Gene names	Jph3, Jp3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

LZTS1_MOUSE
θ value	3.0926 (rank : 61)	NC score	0.020468 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	540	Shared Neighborhood Hits	36
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

MACF1_HUMAN
θ value	3.0926 (rank : 62)	NC score	0.022404 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	1341	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF1_MOUSE
θ value	3.0926 (rank : 63)	NC score	0.019817 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	1313	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACF4_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.025595 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	1321	Shared Neighborhood Hits	42
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MYH11_MOUSE
θ value	3.0926 (rank : 65)	NC score	0.031605 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	1777	Shared Neighborhood Hits	47
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PIAS1_HUMAN
θ value	3.0926 (rank : 66)	NC score	0.006752 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

SM1L2_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.022935 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	1019	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SMC4_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.027022 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	937	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

CCD21_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.017238 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	1228	Shared Neighborhood Hits	43
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

MYH11_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.029893 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	1806	Shared Neighborhood Hits	44
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

BRE1B_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.026060 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	1040	Shared Neighborhood Hits	44
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	5.27518 (rank : 72)	NC score	0.027058 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	970	Shared Neighborhood Hits	42
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

LAD1_HUMAN
θ value	5.27518 (rank : 73)	NC score	0.008927 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	441	Shared Neighborhood Hits	11
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

MYH14_MOUSE
θ value	5.27518 (rank : 74)	NC score	0.031939 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	1225	Shared Neighborhood Hits	41
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH3_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.033227 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	1660	Shared Neighborhood Hits	45
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

2A5A_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.004129 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PD03, Q8R1U7	Gene names	Ppp2r5a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit, B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, B subunit, R5 alpha isoform) (PR61alpha).

DESM_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.006961 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	495	Shared Neighborhood Hits	36
SwissProt Accessions	P17661, Q15787, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80	Gene names	DES
Domain Architecture
Description	Desmin.

E41L2_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.004000 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	459	Shared Neighborhood Hits	14
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

GOGA3_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.021145 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	1437	Shared Neighborhood Hits	44
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

MYH6_MOUSE
θ value	6.88961 (rank : 80)	NC score	0.034163 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	1501	Shared Neighborhood Hits	46
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.033789 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	1559	Shared Neighborhood Hits	46
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH9_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.029271 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	1762	Shared Neighborhood Hits	44
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RADI_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.014008 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	773	Shared Neighborhood Hits	41
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

SM1L2_MOUSE
θ value	6.88961 (rank : 84)	NC score	0.023909 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	918	Shared Neighborhood Hits	42
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SMCA2_HUMAN
θ value	6.88961 (rank : 85)	NC score	0.006943 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	503	Shared Neighborhood Hits	24
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SPAST_MOUSE
θ value	6.88961 (rank : 86)	NC score	0.001796 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

AKAP9_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.016849 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	1710	Shared Neighborhood Hits	42
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ANR47_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.002642 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	350	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

CD2L1_MOUSE
θ value	8.99809 (rank : 89)	NC score	-0.002737 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	1463	Shared Neighborhood Hits	29
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

ERC2_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.018993 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	1156	Shared Neighborhood Hits	42
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	8.99809 (rank : 91)	NC score	0.018894 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	1166	Shared Neighborhood Hits	42
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

MYH6_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.034101 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	1426	Shared Neighborhood Hits	46
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH9_MOUSE
θ value	8.99809 (rank : 93)	NC score	0.028956 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	1829	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

Hits sorted by NC score

PDE9A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
NC score	0.997194 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	72	Shared Neighborhood Hits	60
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE7A_HUMAN
NC score	0.931451 (rank : 3)	θ value	1.28434e-38 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
NC score	0.930596 (rank : 4)	θ value	3.73686e-38 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7B_MOUSE
NC score	0.929270 (rank : 5)	θ value	9.20422e-37 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.928468 (rank : 6)	θ value	3.4976e-36 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE4C_MOUSE
NC score	0.923592 (rank : 7)	θ value	8.04462e-41 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4C_HUMAN
NC score	0.922384 (rank : 8)	θ value	2.50074e-42 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4B_HUMAN
NC score	0.920494 (rank : 9)	θ value	2.67181e-44 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4D_MOUSE
NC score	0.919695 (rank : 10)	θ value	2.04573e-44 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_MOUSE
NC score	0.919635 (rank : 11)	θ value	3.48949e-44 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4A_HUMAN
NC score	0.919377 (rank : 12)	θ value	3.48949e-44 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4D_HUMAN
NC score	0.919051 (rank : 13)	θ value	2.67181e-44 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	122	Shared Neighborhood Hits	41
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE1B_MOUSE
NC score	0.917216 (rank : 14)	θ value	2.42216e-37 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	46	Shared Neighborhood Hits	39
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8A_HUMAN
NC score	0.916591 (rank : 15)	θ value	1.46607e-42 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE1A_MOUSE
NC score	0.915018 (rank : 16)	θ value	1.57e-36 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1B_HUMAN
NC score	0.914837 (rank : 17)	θ value	1.20211e-36 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	41
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.913256 (rank : 18)	θ value	1.32909e-35 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE8B_HUMAN
NC score	0.913086 (rank : 19)	θ value	2.34062e-40 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE8A_MOUSE
NC score	0.912621 (rank : 20)	θ value	1.98146e-39 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE1C_HUMAN
NC score	0.903547 (rank : 21)	θ value	6.59618e-35 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.902329 (rank : 22)	θ value	3.27365e-34 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE2A_MOUSE
NC score	0.901064 (rank : 23)	θ value	4.88048e-38 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.900231 (rank : 24)	θ value	4.88048e-38 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.889931 (rank : 25)	θ value	3.37985e-39 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.889898 (rank : 26)	θ value	8.89434e-40 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	39
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE3B_HUMAN
NC score	0.884607 (rank : 27)	θ value	2.96777e-27 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE10_HUMAN
NC score	0.879796 (rank : 28)	θ value	6.61148e-27 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE3A_HUMAN
NC score	0.874453 (rank : 29)	θ value	1.57365e-28 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.873256 (rank : 30)	θ value	7.80994e-28 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE5A_MOUSE
NC score	0.871769 (rank : 31)	θ value	2.34606e-32 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.869579 (rank : 32)	θ value	3.06405e-32 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.854186 (rank : 33)	θ value	2.42779e-29 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.853302 (rank : 34)	θ value	1.08979e-29 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.850441 (rank : 35)	θ value	1.28732e-30 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6B_HUMAN
NC score	0.848812 (rank : 36)	θ value	1.28732e-30 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
NC score	0.847671 (rank : 37)	θ value	1.16434e-31 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_MOUSE
NC score	0.846012 (rank : 38)	θ value	3.50572e-28 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

SESN1_MOUSE
NC score	0.061199 (rank : 39)	θ value	0.00134147 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

PDCD7_MOUSE
NC score	0.054919 (rank : 40)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	214	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

SESN1_HUMAN
NC score	0.053079 (rank : 41)	θ value	0.0148317 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6P5, Q9NV00, Q9UPD5, Q9Y6P6	Gene names	SESN1, PA26, SEST1
Domain Architecture
Description	Sestrin-1 (p53-regulated protein PA26).

MYH2_HUMAN
NC score	0.039144 (rank : 42)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	1491	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH1_MOUSE
NC score	0.038961 (rank : 43)	θ value	0.0736092 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	1461	Shared Neighborhood Hits	45
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH1_HUMAN
NC score	0.038709 (rank : 44)	θ value	0.0736092 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	1478	Shared Neighborhood Hits	45
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH4_MOUSE
NC score	0.038377 (rank : 45)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	1476	Shared Neighborhood Hits	45
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH8_MOUSE
NC score	0.038204 (rank : 46)	θ value	0.0563607 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	1600	Shared Neighborhood Hits	45
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH4_HUMAN
NC score	0.037698 (rank : 47)	θ value	0.62314 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	1377	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

PARC_HUMAN
NC score	0.037135 (rank : 48)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

MYH8_HUMAN
NC score	0.036697 (rank : 49)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	1610	Shared Neighborhood Hits	46
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH13_HUMAN
NC score	0.036120 (rank : 50)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	1504	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH6_MOUSE
NC score	0.034163 (rank : 51)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	1501	Shared Neighborhood Hits	46
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_HUMAN
NC score	0.034101 (rank : 52)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	1426	Shared Neighborhood Hits	46
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
NC score	0.033789 (rank : 53)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	1559	Shared Neighborhood Hits	46
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

PDCD7_HUMAN
NC score	0.033366 (rank : 54)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	255	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

MYH3_HUMAN
NC score	0.033227 (rank : 55)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	1660	Shared Neighborhood Hits	45
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH14_MOUSE
NC score	0.031939 (rank : 56)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	1225	Shared Neighborhood Hits	41
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH11_MOUSE
NC score	0.031605 (rank : 57)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	1777	Shared Neighborhood Hits	47
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PARC_MOUSE
NC score	0.030997 (rank : 58)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

MYH11_HUMAN
NC score	0.029893 (rank : 59)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	1806	Shared Neighborhood Hits	44
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH9_HUMAN
NC score	0.029271 (rank : 60)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	1762	Shared Neighborhood Hits	44
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
NC score	0.028956 (rank : 61)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	1829	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CING_HUMAN
NC score	0.028873 (rank : 62)	θ value	0.47712 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	1275	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

BRE1B_MOUSE
NC score	0.027058 (rank : 63)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	970	Shared Neighborhood Hits	42
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

SMC4_HUMAN
NC score	0.027022 (rank : 64)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	937	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

BRE1B_HUMAN
NC score	0.026060 (rank : 65)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	1040	Shared Neighborhood Hits	44
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CING_MOUSE
NC score	0.025808 (rank : 66)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	1432	Shared Neighborhood Hits	44
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

MACF4_HUMAN
NC score	0.025595 (rank : 67)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	1321	Shared Neighborhood Hits	42
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

TMF1_HUMAN
NC score	0.025413 (rank : 68)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	987	Shared Neighborhood Hits	40
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

CCD41_MOUSE
NC score	0.024103 (rank : 69)	θ value	0.62314 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	1399	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

SM1L2_MOUSE
NC score	0.023909 (rank : 70)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	918	Shared Neighborhood Hits	42
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SM1L2_HUMAN
NC score	0.022935 (rank : 71)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	1019	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

MACF1_HUMAN
NC score	0.022404 (rank : 72)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	1341	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

CENPF_HUMAN
NC score	0.021983 (rank : 73)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	1932	Shared Neighborhood Hits	43
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

GOGA3_MOUSE
NC score	0.021145 (rank : 74)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	1437	Shared Neighborhood Hits	44
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

LZTS1_MOUSE
NC score	0.020468 (rank : 75)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	540	Shared Neighborhood Hits	36
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

MACF1_MOUSE
NC score	0.019817 (rank : 76)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	1313	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

ERC2_HUMAN
NC score	0.018993 (rank : 77)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	1156	Shared Neighborhood Hits	42
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
NC score	0.018894 (rank : 78)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	1166	Shared Neighborhood Hits	42
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

CCD21_HUMAN
NC score	0.017238 (rank : 79)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	1228	Shared Neighborhood Hits	43
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

RADI_HUMAN
NC score	0.016916 (rank : 80)	θ value	0.47712 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	741	Shared Neighborhood Hits	41
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

AKAP9_HUMAN
NC score	0.016849 (rank : 81)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	1710	Shared Neighborhood Hits	42
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

RADI_MOUSE
NC score	0.014008 (rank : 82)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	773	Shared Neighborhood Hits	41
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

LAD1_HUMAN
NC score	0.008927 (rank : 83)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	441	Shared Neighborhood Hits	11
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

JPH3_MOUSE
NC score	0.007104 (rank : 84)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ET77, Q9EQZ2	Gene names	Jph3, Jp3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

DESM_HUMAN
NC score	0.006961 (rank : 85)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	495	Shared Neighborhood Hits	36
SwissProt Accessions	P17661, Q15787, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80	Gene names	DES
Domain Architecture
Description	Desmin.

SMCA2_HUMAN
NC score	0.006943 (rank : 86)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	503	Shared Neighborhood Hits	24
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

PIAS1_HUMAN
NC score	0.006752 (rank : 87)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

2A5A_MOUSE
NC score	0.004129 (rank : 88)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PD03, Q8R1U7	Gene names	Ppp2r5a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A, B subunit, B' alpha isoform) (PP2A, B subunit, B56 alpha isoform) (PP2A, B subunit, PR61 alpha isoform) (PP2A, B subunit, R5 alpha isoform) (PR61alpha).

E41L2_MOUSE
NC score	0.004000 (rank : 89)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	459	Shared Neighborhood Hits	14
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

ANR47_MOUSE
NC score	0.002642 (rank : 90)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	350	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

SPAST_MOUSE
NC score	0.001796 (rank : 91)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

CD2L1_MOUSE
NC score	-0.002737 (rank : 92)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	1463	Shared Neighborhood Hits	29
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

SPEG_MOUSE
NC score	-0.004046 (rank : 93)	θ value	0.813845 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	1959	Shared Neighborhood Hits	5
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).