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Network neighborhood for query Sequence : SESN1_HUMAN

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SESN1_HUMAN
SwissProt Accessions	Q9Y6P5, Q9NV00, Q9UPD5, Q9Y6P6	Gene names	SESN1, PA26, SEST1
Domain Architecture
Description	Sestrin-1 (p53-regulated protein PA26).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SESN1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6P5, Q9NV00, Q9UPD5, Q9Y6P6	Gene names	SESN1, PA26, SEST1
Domain Architecture
Description	Sestrin-1 (p53-regulated protein PA26).

SESN1_MOUSE
θ value	0 (rank : 2)	NC score	0.998820 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

SESN3_HUMAN
θ value	7.7336e-177 (rank : 3)	NC score	0.990324 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P58005, Q96AD1	Gene names	SESN3, SEST3
Domain Architecture
Description	Sestrin-3.

SESN3_MOUSE
θ value	6.34118e-171 (rank : 4)	NC score	0.990588 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CYP7, Q3U2A0	Gene names	Sesn3, Sest3
Domain Architecture
Description	Sestrin-3.

SESN2_MOUSE
θ value	8.61018e-152 (rank : 5)	NC score	0.985639 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P58043	Gene names	Sesn2, Sest2
Domain Architecture
Description	Sestrin-2.

SESN2_HUMAN
θ value	1.12453e-151 (rank : 6)	NC score	0.985241 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	P58004, Q96SI5	Gene names	SESN2, SEST2
Domain Architecture
Description	Sestrin-2 (Hi95).

PDE9A_HUMAN
θ value	0.0148317 (rank : 7)	NC score	0.053079 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
θ value	0.0736092 (rank : 8)	NC score	0.048988 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

EHMT2_HUMAN
θ value	1.38821 (rank : 9)	NC score	0.010904 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	498	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

UBP8_HUMAN
θ value	1.38821 (rank : 10)	NC score	0.008794 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	751	Shared Neighborhood Hits	4
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

EHMT2_MOUSE
θ value	1.81305 (rank : 11)	NC score	0.010269 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	750	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

DAXX_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.017332 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

GON4L_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.013042 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	555	Shared Neighborhood Hits	7
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

SF3B2_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.017431 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

SMCE1_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.009358 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	409	Shared Neighborhood Hits	7
SwissProt Accessions	O54941, Q8BPD9	Gene names	Smarce1, Baf57
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1 (BRG1-associated factor 57).

PELP1_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.006407 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	596	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

Hits sorted by NC score

SESN1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6P5, Q9NV00, Q9UPD5, Q9Y6P6	Gene names	SESN1, PA26, SEST1
Domain Architecture
Description	Sestrin-1 (p53-regulated protein PA26).

SESN1_MOUSE
NC score	0.998820 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P58006, Q7TNF3	Gene names	Sesn1, Pa26, Sest1
Domain Architecture	No domain graphic available
Description	Sestrin-1 (p53-regulated protein PA26).

SESN3_MOUSE
NC score	0.990588 (rank : 3)	θ value	6.34118e-171 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CYP7, Q3U2A0	Gene names	Sesn3, Sest3
Domain Architecture
Description	Sestrin-3.

SESN3_HUMAN
NC score	0.990324 (rank : 4)	θ value	7.7336e-177 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P58005, Q96AD1	Gene names	SESN3, SEST3
Domain Architecture
Description	Sestrin-3.

SESN2_MOUSE
NC score	0.985639 (rank : 5)	θ value	8.61018e-152 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P58043	Gene names	Sesn2, Sest2
Domain Architecture
Description	Sestrin-2.

SESN2_HUMAN
NC score	0.985241 (rank : 6)	θ value	1.12453e-151 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	P58004, Q96SI5	Gene names	SESN2, SEST2
Domain Architecture
Description	Sestrin-2 (Hi95).

PDE9A_HUMAN
NC score	0.053079 (rank : 7)	θ value	0.0148317 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
NC score	0.048988 (rank : 8)	θ value	0.0736092 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

SF3B2_HUMAN
NC score	0.017431 (rank : 9)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

DAXX_HUMAN
NC score	0.017332 (rank : 10)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

GON4L_HUMAN
NC score	0.013042 (rank : 11)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	555	Shared Neighborhood Hits	7
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

EHMT2_HUMAN
NC score	0.010904 (rank : 12)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	498	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EHMT2_MOUSE
NC score	0.010269 (rank : 13)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	750	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

SMCE1_MOUSE
NC score	0.009358 (rank : 14)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	409	Shared Neighborhood Hits	7
SwissProt Accessions	O54941, Q8BPD9	Gene names	Smarce1, Baf57
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1 (BRG1-associated factor 57).

UBP8_HUMAN
NC score	0.008794 (rank : 15)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	751	Shared Neighborhood Hits	4
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

PELP1_HUMAN
NC score	0.006407 (rank : 16)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	596	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).