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Network neighborhood for query Sequence : PDE4D_HUMAN

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PDE4D_HUMAN
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE4A_HUMAN
θ value	0 (rank : 1)	NC score	0.994788 (rank : 7)
Query Neighborhood Hits	122	Target Neighborhood Hits	73	Shared Neighborhood Hits	40
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
θ value	0 (rank : 2)	NC score	0.994999 (rank : 6)
Query Neighborhood Hits	122	Target Neighborhood Hits	66	Shared Neighborhood Hits	42
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4B_HUMAN
θ value	0 (rank : 3)	NC score	0.995957 (rank : 3)
Query Neighborhood Hits	122	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
θ value	0 (rank : 4)	NC score	0.995745 (rank : 4)
Query Neighborhood Hits	122	Target Neighborhood Hits	56	Shared Neighborhood Hits	41
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
θ value	0 (rank : 5)	NC score	0.995112 (rank : 5)
Query Neighborhood Hits	122	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_HUMAN
θ value	0 (rank : 6)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	122	Target Neighborhood Hits	122	Shared Neighborhood Hits	122
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
θ value	0 (rank : 7)	NC score	0.998441 (rank : 2)
Query Neighborhood Hits	122	Target Neighborhood Hits	98	Shared Neighborhood Hits	85
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE1A_HUMAN
θ value	2.10232e-65 (rank : 8)	NC score	0.933515 (rank : 14)
Query Neighborhood Hits	122	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1A_MOUSE
θ value	3.96481e-64 (rank : 9)	NC score	0.933728 (rank : 13)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1C_HUMAN
θ value	7.47731e-63 (rank : 10)	NC score	0.923249 (rank : 16)
Query Neighborhood Hits	122	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	1.27544e-62 (rank : 11)	NC score	0.922634 (rank : 18)
Query Neighborhood Hits	122	Target Neighborhood Hits	161	Shared Neighborhood Hits	43
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE1B_HUMAN
θ value	2.40537e-61 (rank : 12)	NC score	0.932122 (rank : 15)
Query Neighborhood Hits	122	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1B_MOUSE
θ value	4.10295e-61 (rank : 13)	NC score	0.933799 (rank : 12)
Query Neighborhood Hits	122	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE7B_HUMAN
θ value	1.01059e-59 (rank : 14)	NC score	0.938322 (rank : 9)
Query Neighborhood Hits	122	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_MOUSE
θ value	8.55514e-59 (rank : 15)	NC score	0.938330 (rank : 8)
Query Neighborhood Hits	122	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8A_HUMAN
θ value	1.36585e-56 (rank : 16)	NC score	0.922693 (rank : 17)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7A_MOUSE
θ value	8.28633e-54 (rank : 17)	NC score	0.935516 (rank : 11)
Query Neighborhood Hits	122	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7A_HUMAN
θ value	1.41344e-53 (rank : 18)	NC score	0.936160 (rank : 10)
Query Neighborhood Hits	122	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE8B_HUMAN
θ value	1.41344e-53 (rank : 19)	NC score	0.920576 (rank : 20)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE8A_MOUSE
θ value	5.37103e-53 (rank : 20)	NC score	0.917437 (rank : 22)
Query Neighborhood Hits	122	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE3B_HUMAN
θ value	4.40402e-47 (rank : 21)	NC score	0.907800 (rank : 23)
Query Neighborhood Hits	122	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE9A_HUMAN
θ value	2.67181e-44 (rank : 22)	NC score	0.919051 (rank : 21)
Query Neighborhood Hits	122	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
θ value	2.67181e-44 (rank : 23)	NC score	0.922355 (rank : 19)
Query Neighborhood Hits	122	Target Neighborhood Hits	72	Shared Neighborhood Hits	39
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE3A_HUMAN
θ value	3.85808e-43 (rank : 24)	NC score	0.891950 (rank : 24)
Query Neighborhood Hits	122	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
θ value	2.76489e-41 (rank : 25)	NC score	0.889414 (rank : 25)
Query Neighborhood Hits	122	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE6A_HUMAN
θ value	1.73584e-35 (rank : 26)	NC score	0.805528 (rank : 35)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE2A_MOUSE
θ value	5.0505e-35 (rank : 27)	NC score	0.853072 (rank : 26)
Query Neighborhood Hits	122	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
θ value	6.59618e-35 (rank : 28)	NC score	0.852154 (rank : 27)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE6A_MOUSE
θ value	3.27365e-34 (rank : 29)	NC score	0.801228 (rank : 37)
Query Neighborhood Hits	122	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_HUMAN
θ value	1.24399e-33 (rank : 30)	NC score	0.801247 (rank : 36)
Query Neighborhood Hits	122	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6C_HUMAN
θ value	1.6247e-33 (rank : 31)	NC score	0.806558 (rank : 34)
Query Neighborhood Hits	122	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6B_MOUSE
θ value	2.12192e-33 (rank : 32)	NC score	0.799339 (rank : 38)
Query Neighborhood Hits	122	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6C_MOUSE
θ value	8.06329e-33 (rank : 33)	NC score	0.807055 (rank : 33)
Query Neighborhood Hits	122	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE11_MOUSE
θ value	1.0531e-32 (rank : 34)	NC score	0.831248 (rank : 29)
Query Neighborhood Hits	122	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_HUMAN
θ value	2.34606e-32 (rank : 35)	NC score	0.831358 (rank : 28)
Query Neighborhood Hits	122	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE5A_HUMAN
θ value	2.68423e-28 (rank : 36)	NC score	0.811634 (rank : 32)
Query Neighborhood Hits	122	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_MOUSE
θ value	1.02001e-27 (rank : 37)	NC score	0.815060 (rank : 31)
Query Neighborhood Hits	122	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
θ value	9.54697e-26 (rank : 38)	NC score	0.830886 (rank : 30)
Query Neighborhood Hits	122	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

AKTS1_MOUSE
θ value	0.0736092 (rank : 39)	NC score	0.053127 (rank : 39)
Query Neighborhood Hits	122	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D1F4	Gene names	Akt1s1, Pras
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (Proline-rich AKT substrate).

AKTS1_HUMAN
θ value	0.125558 (rank : 40)	NC score	0.043355 (rank : 40)
Query Neighborhood Hits	122	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q96B36, Q96BI4, Q96IK7, Q96NG2, Q9BWR5	Gene names	AKT1S1, PRAS40
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate).

POF1B_MOUSE
θ value	0.279714 (rank : 41)	NC score	0.021056 (rank : 43)
Query Neighborhood Hits	122	Target Neighborhood Hits	530	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

DMP1_HUMAN
θ value	0.365318 (rank : 42)	NC score	0.027938 (rank : 41)
Query Neighborhood Hits	122	Target Neighborhood Hits	491	Shared Neighborhood Hits	31
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

GCC2_HUMAN
θ value	0.813845 (rank : 43)	NC score	0.009595 (rank : 70)
Query Neighborhood Hits	122	Target Neighborhood Hits	1558	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

LEO1_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.019533 (rank : 44)
Query Neighborhood Hits	122	Target Neighborhood Hits	946	Shared Neighborhood Hits	37
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

RBP24_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.009582 (rank : 71)
Query Neighborhood Hits	122	Target Neighborhood Hits	1559	Shared Neighborhood Hits	29
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

WDFY3_MOUSE
θ value	0.813845 (rank : 46)	NC score	0.010092 (rank : 64)
Query Neighborhood Hits	122	Target Neighborhood Hits	332	Shared Neighborhood Hits	9
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

SFR12_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.017833 (rank : 45)
Query Neighborhood Hits	122	Target Neighborhood Hits	553	Shared Neighborhood Hits	19
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

CD2_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.010758 (rank : 62)
Query Neighborhood Hits	122	Target Neighborhood Hits	504	Shared Neighborhood Hits	11
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

NUPL_HUMAN
θ value	1.38821 (rank : 49)	NC score	0.016225 (rank : 51)
Query Neighborhood Hits	122	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

CALX_MOUSE
θ value	1.81305 (rank : 50)	NC score	0.016709 (rank : 49)
Query Neighborhood Hits	122	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	P35564	Gene names	Canx
Domain Architecture
Description	Calnexin precursor.

ERBB2_HUMAN
θ value	1.81305 (rank : 51)	NC score	-0.003467 (rank : 119)
Query Neighborhood Hits	122	Target Neighborhood Hits	1073	Shared Neighborhood Hits	7
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

GNL1_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.016173 (rank : 52)
Query Neighborhood Hits	122	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P36916	Gene names	Gnl1, Gna-rs1, Mmr1
Domain Architecture
Description	Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1).

KI21A_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.004531 (rank : 94)
Query Neighborhood Hits	122	Target Neighborhood Hits	1543	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

MYST4_HUMAN
θ value	1.81305 (rank : 54)	NC score	0.013136 (rank : 56)
Query Neighborhood Hits	122	Target Neighborhood Hits	671	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

MYT1_MOUSE
θ value	1.81305 (rank : 55)	NC score	0.011900 (rank : 58)
Query Neighborhood Hits	122	Target Neighborhood Hits	385	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

NSBP1_MOUSE
θ value	1.81305 (rank : 56)	NC score	0.016249 (rank : 50)
Query Neighborhood Hits	122	Target Neighborhood Hits	681	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

ADDB_MOUSE
θ value	2.36792 (rank : 57)	NC score	0.007311 (rank : 81)
Query Neighborhood Hits	122	Target Neighborhood Hits	574	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

BPTF_HUMAN
θ value	2.36792 (rank : 58)	NC score	0.007993 (rank : 78)
Query Neighborhood Hits	122	Target Neighborhood Hits	786	Shared Neighborhood Hits	34
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CRSP7_HUMAN
θ value	2.36792 (rank : 59)	NC score	0.011249 (rank : 61)
Query Neighborhood Hits	122	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

GCC2_MOUSE
θ value	2.36792 (rank : 60)	NC score	0.007308 (rank : 82)
Query Neighborhood Hits	122	Target Neighborhood Hits	1619	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

OSBL5_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.006222 (rank : 85)
Query Neighborhood Hits	122	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

REST_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.006678 (rank : 83)
Query Neighborhood Hits	122	Target Neighborhood Hits	1506	Shared Neighborhood Hits	31
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SYCM_MOUSE
θ value	2.36792 (rank : 63)	NC score	0.021784 (rank : 42)
Query Neighborhood Hits	122	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BYM8, Q9D6U9	Gene names	Cars2
Domain Architecture	No domain graphic available
Description	Probable cysteinyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

ZHX3_HUMAN
θ value	2.36792 (rank : 64)	NC score	0.009859 (rank : 67)
Query Neighborhood Hits	122	Target Neighborhood Hits	331	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4I2, O43145	Gene names	ZHX3, KIAA0395, TIX1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

ANK2_HUMAN
θ value	3.0926 (rank : 65)	NC score	-0.000585 (rank : 113)
Query Neighborhood Hits	122	Target Neighborhood Hits	1615	Shared Neighborhood Hits	33
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

AP3B1_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.009727 (rank : 68)
Query Neighborhood Hits	122	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CD2L2_HUMAN
θ value	3.0926 (rank : 67)	NC score	-0.002278 (rank : 116)
Query Neighborhood Hits	122	Target Neighborhood Hits	1439	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

FMN1A_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.017666 (rank : 46)
Query Neighborhood Hits	122	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	3.0926 (rank : 69)	NC score	0.017322 (rank : 47)
Query Neighborhood Hits	122	Target Neighborhood Hits	447	Shared Neighborhood Hits	17
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

MDC1_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.005671 (rank : 89)
Query Neighborhood Hits	122	Target Neighborhood Hits	1446	Shared Neighborhood Hits	36
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MYH10_HUMAN
θ value	3.0926 (rank : 71)	NC score	0.000976 (rank : 112)
Query Neighborhood Hits	122	Target Neighborhood Hits	1620	Shared Neighborhood Hits	32
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYT1L_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.013798 (rank : 55)
Query Neighborhood Hits	122	Target Neighborhood Hits	461	Shared Neighborhood Hits	26
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

STIM1_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.011453 (rank : 60)
Query Neighborhood Hits	122	Target Neighborhood Hits	665	Shared Neighborhood Hits	24
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

K0146_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.009722 (rank : 69)
Query Neighborhood Hits	122	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q14159, Q96BI5	Gene names	KIAA0146
Domain Architecture	No domain graphic available
Description	Protein KIAA0146.

MLL3_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.001252 (rank : 111)
Query Neighborhood Hits	122	Target Neighborhood Hits	1644	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SNX23_HUMAN
θ value	4.03905 (rank : 76)	NC score	0.003280 (rank : 105)
Query Neighborhood Hits	122	Target Neighborhood Hits	944	Shared Neighborhood Hits	21
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

SVIL_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.005426 (rank : 90)
Query Neighborhood Hits	122	Target Neighborhood Hits	439	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

AN32B_HUMAN
θ value	5.27518 (rank : 78)	NC score	0.010617 (rank : 63)
Query Neighborhood Hits	122	Target Neighborhood Hits	243	Shared Neighborhood Hits	12
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

FACD2_MOUSE
θ value	5.27518 (rank : 79)	NC score	0.010022 (rank : 65)
Query Neighborhood Hits	122	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	Q80V62, Q9CWC7	Gene names	Fancd2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein homolog (Protein FACD2).

GOGA3_MOUSE
θ value	5.27518 (rank : 80)	NC score	0.003057 (rank : 106)
Query Neighborhood Hits	122	Target Neighborhood Hits	1437	Shared Neighborhood Hits	31
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

HUWE1_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.008949 (rank : 74)
Query Neighborhood Hits	122	Target Neighborhood Hits	443	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	5.27518 (rank : 82)	NC score	0.007530 (rank : 79)
Query Neighborhood Hits	122	Target Neighborhood Hits	406	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

JPH2_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.005218 (rank : 91)
Query Neighborhood Hits	122	Target Neighborhood Hits	639	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LAMA2_MOUSE
θ value	5.27518 (rank : 84)	NC score	0.001304 (rank : 110)
Query Neighborhood Hits	122	Target Neighborhood Hits	1198	Shared Neighborhood Hits	25
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LTBP3_HUMAN
θ value	5.27518 (rank : 85)	NC score	-0.000896 (rank : 114)
Query Neighborhood Hits	122	Target Neighborhood Hits	502	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

MYH4_MOUSE
θ value	5.27518 (rank : 86)	NC score	0.003042 (rank : 107)
Query Neighborhood Hits	122	Target Neighborhood Hits	1476	Shared Neighborhood Hits	36
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

SIP1_MOUSE
θ value	5.27518 (rank : 87)	NC score	-0.001970 (rank : 115)
Query Neighborhood Hits	122	Target Neighborhood Hits	870	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

STIM1_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.010000 (rank : 66)
Query Neighborhood Hits	122	Target Neighborhood Hits	660	Shared Neighborhood Hits	24
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

TP53B_HUMAN
θ value	5.27518 (rank : 89)	NC score	0.015153 (rank : 54)
Query Neighborhood Hits	122	Target Neighborhood Hits	413	Shared Neighborhood Hits	23
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

UBP36_HUMAN
θ value	5.27518 (rank : 90)	NC score	0.002559 (rank : 108)
Query Neighborhood Hits	122	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

ZHX3_MOUSE
θ value	5.27518 (rank : 91)	NC score	0.007322 (rank : 80)
Query Neighborhood Hits	122	Target Neighborhood Hits	321	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0Q2, Q80U14	Gene names	Zhx3, Kiaa0395, Tix1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

ZN282_HUMAN
θ value	5.27518 (rank : 92)	NC score	-0.004812 (rank : 121)
Query Neighborhood Hits	122	Target Neighborhood Hits	796	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UDV7, O43691, Q6DKK0	Gene names	ZNF282, HUB1
Domain Architecture
Description	Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1).

ZN645_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.008451 (rank : 76)
Query Neighborhood Hits	122	Target Neighborhood Hits	265	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

AFF3_HUMAN
θ value	6.88961 (rank : 94)	NC score	0.009489 (rank : 73)
Query Neighborhood Hits	122	Target Neighborhood Hits	190	Shared Neighborhood Hits	12
SwissProt Accessions	P51826	Gene names	AFF3, LAF4
Domain Architecture
Description	AF4/FMR2 family member 3 (Protein LAF-4) (Lymphoid nuclear protein related to AF4).

AKA12_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.008205 (rank : 77)
Query Neighborhood Hits	122	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

AMPD3_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.004258 (rank : 96)
Query Neighborhood Hits	122	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q01432	Gene names	AMPD3
Domain Architecture
Description	AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase).

B3A3_HUMAN
θ value	6.88961 (rank : 97)	NC score	0.003635 (rank : 103)
Query Neighborhood Hits	122	Target Neighborhood Hits	119	Shared Neighborhood Hits	6
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

BAZ2B_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.005855 (rank : 88)
Query Neighborhood Hits	122	Target Neighborhood Hits	803	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BCCIP_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.011963 (rank : 57)
Query Neighborhood Hits	122	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P287, Q8ND15, Q96GC4, Q9P288	Gene names	BCCIP, TOK1
Domain Architecture	No domain graphic available
Description	BRCA2 and CDKN1A-interacting protein (Protein TOK-1).

CALX_HUMAN
θ value	6.88961 (rank : 100)	NC score	0.011784 (rank : 59)
Query Neighborhood Hits	122	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	P27824	Gene names	CANX
Domain Architecture
Description	Calnexin precursor (Major histocompatibility complex class I antigen- binding protein p88) (p90) (IP90).

CD2L1_HUMAN
θ value	6.88961 (rank : 101)	NC score	-0.002606 (rank : 117)
Query Neighborhood Hits	122	Target Neighborhood Hits	1467	Shared Neighborhood Hits	30
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CEP72_HUMAN
θ value	6.88961 (rank : 102)	NC score	0.006210 (rank : 86)
Query Neighborhood Hits	122	Target Neighborhood Hits	374	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

GPS2_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.006305 (rank : 84)
Query Neighborhood Hits	122	Target Neighborhood Hits	459	Shared Neighborhood Hits	15
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

NBN_HUMAN
θ value	6.88961 (rank : 104)	NC score	0.008464 (rank : 75)
Query Neighborhood Hits	122	Target Neighborhood Hits	226	Shared Neighborhood Hits	10
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

PP1R7_HUMAN
θ value	6.88961 (rank : 105)	NC score	0.002142 (rank : 109)
Query Neighborhood Hits	122	Target Neighborhood Hits	265	Shared Neighborhood Hits	5
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

SMOC1_MOUSE
θ value	6.88961 (rank : 106)	NC score	0.003785 (rank : 100)
Query Neighborhood Hits	122	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SYNE2_HUMAN
θ value	6.88961 (rank : 107)	NC score	0.004138 (rank : 98)
Query Neighborhood Hits	122	Target Neighborhood Hits	1323	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TTC1_HUMAN
θ value	6.88961 (rank : 108)	NC score	0.004346 (rank : 95)
Query Neighborhood Hits	122	Target Neighborhood Hits	417	Shared Neighborhood Hits	27
SwissProt Accessions	Q99614, Q9BVT3	Gene names	TTC1, TPR1
Domain Architecture
Description	Tetratricopeptide repeat protein 1 (TPR repeat protein 1).

AFF1_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.006119 (rank : 87)
Query Neighborhood Hits	122	Target Neighborhood Hits	351	Shared Neighborhood Hits	16
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

AQR_MOUSE
θ value	8.99809 (rank : 110)	NC score	0.003889 (rank : 99)
Query Neighborhood Hits	122	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

B3A3_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.003569 (rank : 104)
Query Neighborhood Hits	122	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

CD2L1_MOUSE
θ value	8.99809 (rank : 112)	NC score	-0.003488 (rank : 120)
Query Neighborhood Hits	122	Target Neighborhood Hits	1463	Shared Neighborhood Hits	27
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CE025_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.017301 (rank : 48)
Query Neighborhood Hits	122	Target Neighborhood Hits	114	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NDZ2, Q6NXN8, Q6ZTU4, Q8IZ15	Gene names	C5orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf25.

HMMR_HUMAN
θ value	8.99809 (rank : 114)	NC score	0.004146 (rank : 97)
Query Neighborhood Hits	122	Target Neighborhood Hits	1082	Shared Neighborhood Hits	26
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

K0562_MOUSE
θ value	8.99809 (rank : 115)	NC score	0.005099 (rank : 92)
Query Neighborhood Hits	122	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q80V31, Q6ZQ95	Gene names	Kiaa0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

K1794_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.015330 (rank : 53)
Query Neighborhood Hits	122	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NVI1, Q96JN1, Q96ST0, Q9BT96	Gene names	KIAA1794
Domain Architecture	No domain graphic available
Description	Protein KIAA1794.

KI21A_MOUSE
θ value	8.99809 (rank : 117)	NC score	0.003636 (rank : 102)
Query Neighborhood Hits	122	Target Neighborhood Hits	1317	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

SF01_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.003717 (rank : 101)
Query Neighborhood Hits	122	Target Neighborhood Hits	287	Shared Neighborhood Hits	9
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SF3A1_HUMAN
θ value	8.99809 (rank : 119)	NC score	0.004671 (rank : 93)
Query Neighborhood Hits	122	Target Neighborhood Hits	199	Shared Neighborhood Hits	6
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

SIP1_HUMAN
θ value	8.99809 (rank : 120)	NC score	-0.002759 (rank : 118)
Query Neighborhood Hits	122	Target Neighborhood Hits	832	Shared Neighborhood Hits	13
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

TCAL5_HUMAN
θ value	8.99809 (rank : 121)	NC score	0.009505 (rank : 72)
Query Neighborhood Hits	122	Target Neighborhood Hits	806	Shared Neighborhood Hits	32
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

ZN516_MOUSE
θ value	8.99809 (rank : 122)	NC score	-0.004887 (rank : 122)
Query Neighborhood Hits	122	Target Neighborhood Hits	1197	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

Hits sorted by NC score

PDE4D_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 6)
Query Neighborhood Hits	122	Target Neighborhood Hits	122	Shared Neighborhood Hits	122
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
NC score	0.998441 (rank : 2)	θ value	0 (rank : 7)
Query Neighborhood Hits	122	Target Neighborhood Hits	98	Shared Neighborhood Hits	85
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4B_HUMAN
NC score	0.995957 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	122	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
NC score	0.995745 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	122	Target Neighborhood Hits	56	Shared Neighborhood Hits	41
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
NC score	0.995112 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	122	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4A_MOUSE
NC score	0.994999 (rank : 6)	θ value	0 (rank : 2)
Query Neighborhood Hits	122	Target Neighborhood Hits	66	Shared Neighborhood Hits	42
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4A_HUMAN
NC score	0.994788 (rank : 7)	θ value	0 (rank : 1)
Query Neighborhood Hits	122	Target Neighborhood Hits	73	Shared Neighborhood Hits	40
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE7B_MOUSE
NC score	0.938330 (rank : 8)	θ value	8.55514e-59 (rank : 15)
Query Neighborhood Hits	122	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.938322 (rank : 9)	θ value	1.01059e-59 (rank : 14)
Query Neighborhood Hits	122	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_HUMAN
NC score	0.936160 (rank : 10)	θ value	1.41344e-53 (rank : 18)
Query Neighborhood Hits	122	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
NC score	0.935516 (rank : 11)	θ value	8.28633e-54 (rank : 17)
Query Neighborhood Hits	122	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE1B_MOUSE
NC score	0.933799 (rank : 12)	θ value	4.10295e-61 (rank : 13)
Query Neighborhood Hits	122	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_MOUSE
NC score	0.933728 (rank : 13)	θ value	3.96481e-64 (rank : 9)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.933515 (rank : 14)	θ value	2.10232e-65 (rank : 8)
Query Neighborhood Hits	122	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_HUMAN
NC score	0.932122 (rank : 15)	θ value	2.40537e-61 (rank : 12)
Query Neighborhood Hits	122	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1C_HUMAN
NC score	0.923249 (rank : 16)	θ value	7.47731e-63 (rank : 10)
Query Neighborhood Hits	122	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE8A_HUMAN
NC score	0.922693 (rank : 17)	θ value	1.36585e-56 (rank : 16)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE1C_MOUSE
NC score	0.922634 (rank : 18)	θ value	1.27544e-62 (rank : 11)
Query Neighborhood Hits	122	Target Neighborhood Hits	161	Shared Neighborhood Hits	43
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE9A_MOUSE
NC score	0.922355 (rank : 19)	θ value	2.67181e-44 (rank : 23)
Query Neighborhood Hits	122	Target Neighborhood Hits	72	Shared Neighborhood Hits	39
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE8B_HUMAN
NC score	0.920576 (rank : 20)	θ value	1.41344e-53 (rank : 19)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE9A_HUMAN
NC score	0.919051 (rank : 21)	θ value	2.67181e-44 (rank : 22)
Query Neighborhood Hits	122	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE8A_MOUSE
NC score	0.917437 (rank : 22)	θ value	5.37103e-53 (rank : 20)
Query Neighborhood Hits	122	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE3B_HUMAN
NC score	0.907800 (rank : 23)	θ value	4.40402e-47 (rank : 21)
Query Neighborhood Hits	122	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_HUMAN
NC score	0.891950 (rank : 24)	θ value	3.85808e-43 (rank : 24)
Query Neighborhood Hits	122	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.889414 (rank : 25)	θ value	2.76489e-41 (rank : 25)
Query Neighborhood Hits	122	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE2A_MOUSE
NC score	0.853072 (rank : 26)	θ value	5.0505e-35 (rank : 27)
Query Neighborhood Hits	122	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.852154 (rank : 27)	θ value	6.59618e-35 (rank : 28)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.831358 (rank : 28)	θ value	2.34606e-32 (rank : 35)
Query Neighborhood Hits	122	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.831248 (rank : 29)	θ value	1.0531e-32 (rank : 34)
Query Neighborhood Hits	122	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE10_HUMAN
NC score	0.830886 (rank : 30)	θ value	9.54697e-26 (rank : 38)
Query Neighborhood Hits	122	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_MOUSE
NC score	0.815060 (rank : 31)	θ value	1.02001e-27 (rank : 37)
Query Neighborhood Hits	122	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.811634 (rank : 32)	θ value	2.68423e-28 (rank : 36)
Query Neighborhood Hits	122	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.807055 (rank : 33)	θ value	8.06329e-33 (rank : 33)
Query Neighborhood Hits	122	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.806558 (rank : 34)	θ value	1.6247e-33 (rank : 31)
Query Neighborhood Hits	122	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.805528 (rank : 35)	θ value	1.73584e-35 (rank : 26)
Query Neighborhood Hits	122	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6B_HUMAN
NC score	0.801247 (rank : 36)	θ value	1.24399e-33 (rank : 30)
Query Neighborhood Hits	122	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_MOUSE
NC score	0.801228 (rank : 37)	θ value	3.27365e-34 (rank : 29)
Query Neighborhood Hits	122	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_MOUSE
NC score	0.799339 (rank : 38)	θ value	2.12192e-33 (rank : 32)
Query Neighborhood Hits	122	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

AKTS1_MOUSE
NC score	0.053127 (rank : 39)	θ value	0.0736092 (rank : 39)
Query Neighborhood Hits	122	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D1F4	Gene names	Akt1s1, Pras
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (Proline-rich AKT substrate).

AKTS1_HUMAN
NC score	0.043355 (rank : 40)	θ value	0.125558 (rank : 40)
Query Neighborhood Hits	122	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q96B36, Q96BI4, Q96IK7, Q96NG2, Q9BWR5	Gene names	AKT1S1, PRAS40
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate).

DMP1_HUMAN
NC score	0.027938 (rank : 41)	θ value	0.365318 (rank : 42)
Query Neighborhood Hits	122	Target Neighborhood Hits	491	Shared Neighborhood Hits	31
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

SYCM_MOUSE
NC score	0.021784 (rank : 42)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	122	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BYM8, Q9D6U9	Gene names	Cars2
Domain Architecture	No domain graphic available
Description	Probable cysteinyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

POF1B_MOUSE
NC score	0.021056 (rank : 43)	θ value	0.279714 (rank : 41)
Query Neighborhood Hits	122	Target Neighborhood Hits	530	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

LEO1_MOUSE
NC score	0.019533 (rank : 44)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	122	Target Neighborhood Hits	946	Shared Neighborhood Hits	37
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

SFR12_HUMAN
NC score	0.017833 (rank : 45)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	122	Target Neighborhood Hits	553	Shared Neighborhood Hits	19
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

FMN1A_MOUSE
NC score	0.017666 (rank : 46)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	122	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
NC score	0.017322 (rank : 47)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	122	Target Neighborhood Hits	447	Shared Neighborhood Hits	17
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

CE025_HUMAN
NC score	0.017301 (rank : 48)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	122	Target Neighborhood Hits	114	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NDZ2, Q6NXN8, Q6ZTU4, Q8IZ15	Gene names	C5orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf25.

CALX_MOUSE
NC score	0.016709 (rank : 49)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	122	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	P35564	Gene names	Canx
Domain Architecture
Description	Calnexin precursor.

NSBP1_MOUSE
NC score	0.016249 (rank : 50)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	122	Target Neighborhood Hits	681	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

NUPL_HUMAN
NC score	0.016225 (rank : 51)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	122	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

GNL1_MOUSE
NC score	0.016173 (rank : 52)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	122	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P36916	Gene names	Gnl1, Gna-rs1, Mmr1
Domain Architecture
Description	Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1).

K1794_HUMAN
NC score	0.015330 (rank : 53)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	122	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NVI1, Q96JN1, Q96ST0, Q9BT96	Gene names	KIAA1794
Domain Architecture	No domain graphic available
Description	Protein KIAA1794.

TP53B_HUMAN
NC score	0.015153 (rank : 54)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	122	Target Neighborhood Hits	413	Shared Neighborhood Hits	23
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

MYT1L_MOUSE
NC score	0.013798 (rank : 55)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	122	Target Neighborhood Hits	461	Shared Neighborhood Hits	26
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

MYST4_HUMAN
NC score	0.013136 (rank : 56)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	122	Target Neighborhood Hits	671	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

BCCIP_HUMAN
NC score	0.011963 (rank : 57)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	122	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P287, Q8ND15, Q96GC4, Q9P288	Gene names	BCCIP, TOK1
Domain Architecture	No domain graphic available
Description	BRCA2 and CDKN1A-interacting protein (Protein TOK-1).

MYT1_MOUSE
NC score	0.011900 (rank : 58)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	122	Target Neighborhood Hits	385	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

CALX_HUMAN
NC score	0.011784 (rank : 59)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	122	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	P27824	Gene names	CANX
Domain Architecture
Description	Calnexin precursor (Major histocompatibility complex class I antigen- binding protein p88) (p90) (IP90).

STIM1_HUMAN
NC score	0.011453 (rank : 60)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	122	Target Neighborhood Hits	665	Shared Neighborhood Hits	24
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

CRSP7_HUMAN
NC score	0.011249 (rank : 61)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	122	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

CD2_HUMAN
NC score	0.010758 (rank : 62)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	122	Target Neighborhood Hits	504	Shared Neighborhood Hits	11
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

AN32B_HUMAN
NC score	0.010617 (rank : 63)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	122	Target Neighborhood Hits	243	Shared Neighborhood Hits	12
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

WDFY3_MOUSE
NC score	0.010092 (rank : 64)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	122	Target Neighborhood Hits	332	Shared Neighborhood Hits	9
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

FACD2_MOUSE
NC score	0.010022 (rank : 65)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	122	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	Q80V62, Q9CWC7	Gene names	Fancd2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein homolog (Protein FACD2).

STIM1_MOUSE
NC score	0.010000 (rank : 66)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	122	Target Neighborhood Hits	660	Shared Neighborhood Hits	24
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

ZHX3_HUMAN
NC score	0.009859 (rank : 67)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	122	Target Neighborhood Hits	331	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4I2, O43145	Gene names	ZHX3, KIAA0395, TIX1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

AP3B1_MOUSE
NC score	0.009727 (rank : 68)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	122	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

K0146_HUMAN
NC score	0.009722 (rank : 69)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	122	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q14159, Q96BI5	Gene names	KIAA0146
Domain Architecture	No domain graphic available
Description	Protein KIAA0146.

GCC2_HUMAN
NC score	0.009595 (rank : 70)	θ value	0.813845 (rank : 43)
Query Neighborhood Hits	122	Target Neighborhood Hits	1558	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.009582 (rank : 71)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	122	Target Neighborhood Hits	1559	Shared Neighborhood Hits	29
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

TCAL5_HUMAN
NC score	0.009505 (rank : 72)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	122	Target Neighborhood Hits	806	Shared Neighborhood Hits	32
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

AFF3_HUMAN
NC score	0.009489 (rank : 73)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	122	Target Neighborhood Hits	190	Shared Neighborhood Hits	12
SwissProt Accessions	P51826	Gene names	AFF3, LAF4
Domain Architecture
Description	AF4/FMR2 family member 3 (Protein LAF-4) (Lymphoid nuclear protein related to AF4).

HUWE1_HUMAN
NC score	0.008949 (rank : 74)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	122	Target Neighborhood Hits	443	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

NBN_HUMAN
NC score	0.008464 (rank : 75)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	122	Target Neighborhood Hits	226	Shared Neighborhood Hits	10
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

ZN645_HUMAN
NC score	0.008451 (rank : 76)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	122	Target Neighborhood Hits	265	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

AKA12_HUMAN
NC score	0.008205 (rank : 77)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	122	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

BPTF_HUMAN
NC score	0.007993 (rank : 78)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	122	Target Neighborhood Hits	786	Shared Neighborhood Hits	34
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

HUWE1_MOUSE
NC score	0.007530 (rank : 79)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	122	Target Neighborhood Hits	406	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ZHX3_MOUSE
NC score	0.007322 (rank : 80)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	122	Target Neighborhood Hits	321	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0Q2, Q80U14	Gene names	Zhx3, Kiaa0395, Tix1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

ADDB_MOUSE
NC score	0.007311 (rank : 81)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	122	Target Neighborhood Hits	574	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

GCC2_MOUSE
NC score	0.007308 (rank : 82)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	122	Target Neighborhood Hits	1619	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

REST_MOUSE
NC score	0.006678 (rank : 83)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	122	Target Neighborhood Hits	1506	Shared Neighborhood Hits	31
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

GPS2_HUMAN
NC score	0.006305 (rank : 84)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	122	Target Neighborhood Hits	459	Shared Neighborhood Hits	15
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

OSBL5_HUMAN
NC score	0.006222 (rank : 85)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	122	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

CEP72_HUMAN
NC score	0.006210 (rank : 86)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	122	Target Neighborhood Hits	374	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

AFF1_MOUSE
NC score	0.006119 (rank : 87)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	122	Target Neighborhood Hits	351	Shared Neighborhood Hits	16
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

BAZ2B_HUMAN
NC score	0.005855 (rank : 88)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	122	Target Neighborhood Hits	803	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

MDC1_HUMAN
NC score	0.005671 (rank : 89)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	122	Target Neighborhood Hits	1446	Shared Neighborhood Hits	36
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SVIL_MOUSE
NC score	0.005426 (rank : 90)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	122	Target Neighborhood Hits	439	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

JPH2_HUMAN
NC score	0.005218 (rank : 91)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	122	Target Neighborhood Hits	639	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

K0562_MOUSE
NC score	0.005099 (rank : 92)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	122	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q80V31, Q6ZQ95	Gene names	Kiaa0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

SF3A1_HUMAN
NC score	0.004671 (rank : 93)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	122	Target Neighborhood Hits	199	Shared Neighborhood Hits	6
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

KI21A_HUMAN
NC score	0.004531 (rank : 94)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	122	Target Neighborhood Hits	1543	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

TTC1_HUMAN
NC score	0.004346 (rank : 95)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	122	Target Neighborhood Hits	417	Shared Neighborhood Hits	27
SwissProt Accessions	Q99614, Q9BVT3	Gene names	TTC1, TPR1
Domain Architecture
Description	Tetratricopeptide repeat protein 1 (TPR repeat protein 1).

AMPD3_HUMAN
NC score	0.004258 (rank : 96)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	122	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q01432	Gene names	AMPD3
Domain Architecture
Description	AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase).

HMMR_HUMAN
NC score	0.004146 (rank : 97)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	122	Target Neighborhood Hits	1082	Shared Neighborhood Hits	26
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

SYNE2_HUMAN
NC score	0.004138 (rank : 98)	θ value	6.88961 (rank : 107)
Query Neighborhood Hits	122	Target Neighborhood Hits	1323	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

AQR_MOUSE
NC score	0.003889 (rank : 99)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	122	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

SMOC1_MOUSE
NC score	0.003785 (rank : 100)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	122	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SF01_HUMAN
NC score	0.003717 (rank : 101)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	122	Target Neighborhood Hits	287	Shared Neighborhood Hits	9
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

KI21A_MOUSE
NC score	0.003636 (rank : 102)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	122	Target Neighborhood Hits	1317	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

B3A3_HUMAN
NC score	0.003635 (rank : 103)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	122	Target Neighborhood Hits	119	Shared Neighborhood Hits	6
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

B3A3_MOUSE
NC score	0.003569 (rank : 104)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	122	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

SNX23_HUMAN
NC score	0.003280 (rank : 105)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	122	Target Neighborhood Hits	944	Shared Neighborhood Hits	21
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

GOGA3_MOUSE
NC score	0.003057 (rank : 106)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	122	Target Neighborhood Hits	1437	Shared Neighborhood Hits	31
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

MYH4_MOUSE
NC score	0.003042 (rank : 107)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	122	Target Neighborhood Hits	1476	Shared Neighborhood Hits	36
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

UBP36_HUMAN
NC score	0.002559 (rank : 108)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	122	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

PP1R7_HUMAN
NC score	0.002142 (rank : 109)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	122	Target Neighborhood Hits	265	Shared Neighborhood Hits	5
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

LAMA2_MOUSE
NC score	0.001304 (rank : 110)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	122	Target Neighborhood Hits	1198	Shared Neighborhood Hits	25
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MLL3_HUMAN
NC score	0.001252 (rank : 111)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	122	Target Neighborhood Hits	1644	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MYH10_HUMAN
NC score	0.000976 (rank : 112)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	122	Target Neighborhood Hits	1620	Shared Neighborhood Hits	32
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

ANK2_HUMAN
NC score	-0.000585 (rank : 113)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	122	Target Neighborhood Hits	1615	Shared Neighborhood Hits	33
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

LTBP3_HUMAN
NC score	-0.000896 (rank : 114)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	122	Target Neighborhood Hits	502	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

SIP1_MOUSE
NC score	-0.001970 (rank : 115)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	122	Target Neighborhood Hits	870	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

CD2L2_HUMAN
NC score	-0.002278 (rank : 116)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	122	Target Neighborhood Hits	1439	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CD2L1_HUMAN
NC score	-0.002606 (rank : 117)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	122	Target Neighborhood Hits	1467	Shared Neighborhood Hits	30
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

SIP1_HUMAN
NC score	-0.002759 (rank : 118)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	122	Target Neighborhood Hits	832	Shared Neighborhood Hits	13
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

ERBB2_HUMAN
NC score	-0.003467 (rank : 119)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	122	Target Neighborhood Hits	1073	Shared Neighborhood Hits	7
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

CD2L1_MOUSE
NC score	-0.003488 (rank : 120)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	122	Target Neighborhood Hits	1463	Shared Neighborhood Hits	27
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

ZN282_HUMAN
NC score	-0.004812 (rank : 121)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	122	Target Neighborhood Hits	796	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UDV7, O43691, Q6DKK0	Gene names	ZNF282, HUB1
Domain Architecture
Description	Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1).

ZN516_MOUSE
NC score	-0.004887 (rank : 122)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	122	Target Neighborhood Hits	1197	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.