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Network neighborhood for query Sequence : NUPL_HUMAN

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NUPL_HUMAN
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NUPL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	0 (rank : 2)	NC score	0.985829 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	113	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

HRBL_MOUSE
θ value	5.00389e-67 (rank : 3)	NC score	0.847500 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	269	Shared Neighborhood Hits	44
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_HUMAN
θ value	2.48917e-58 (rank : 4)	NC score	0.878232 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

SMAP1_HUMAN
θ value	3.52202e-12 (rank : 5)	NC score	0.651969 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	3.52202e-12 (rank : 6)	NC score	0.647527 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	120	Shared Neighborhood Hits	37
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	3.89403e-11 (rank : 7)	NC score	0.639209 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	3.89403e-11 (rank : 8)	NC score	0.640016 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	70	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CENA1_HUMAN
θ value	1.133e-10 (rank : 9)	NC score	0.614595 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

ARFG1_HUMAN
θ value	4.30538e-10 (rank : 10)	NC score	0.589110 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENG2_MOUSE
θ value	4.76016e-09 (rank : 11)	NC score	0.440333 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	463	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
θ value	1.38499e-08 (rank : 12)	NC score	0.437143 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	471	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG3_HUMAN
θ value	2.61198e-07 (rank : 13)	NC score	0.443634 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	455	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	2.61198e-07 (rank : 14)	NC score	0.444022 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	467	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

ARFG1_MOUSE
θ value	9.92553e-07 (rank : 15)	NC score	0.576834 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	51	Shared Neighborhood Hits	36
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENA2_MOUSE
θ value	1.69304e-06 (rank : 16)	NC score	0.577606 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENB2_HUMAN
θ value	2.21117e-06 (rank : 17)	NC score	0.397499 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	425	Shared Neighborhood Hits	37
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	3.77169e-06 (rank : 18)	NC score	0.405287 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	395	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG1_MOUSE
θ value	3.77169e-06 (rank : 19)	NC score	0.443573 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	531	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
θ value	4.92598e-06 (rank : 20)	NC score	0.437593 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	544	Shared Neighborhood Hits	42
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENA2_HUMAN
θ value	8.40245e-06 (rank : 21)	NC score	0.566672 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	83	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ARFG3_MOUSE
θ value	1.09739e-05 (rank : 22)	NC score	0.526127 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	80	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_HUMAN
θ value	4.1701e-05 (rank : 23)	NC score	0.528640 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

CEND1_MOUSE
θ value	4.1701e-05 (rank : 24)	NC score	0.379255 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	260	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND3_MOUSE
θ value	9.29e-05 (rank : 25)	NC score	0.372094 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
θ value	0.000121331 (rank : 26)	NC score	0.371707 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND1_HUMAN
θ value	0.00020696 (rank : 27)	NC score	0.375709 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	284	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

GP112_HUMAN
θ value	0.000270298 (rank : 28)	NC score	0.054244 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	441	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

DDEF1_MOUSE
θ value	0.000786445 (rank : 29)	NC score	0.386915 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	592	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	0.00134147 (rank : 30)	NC score	0.377158 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	599	Shared Neighborhood Hits	38
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CENB1_HUMAN
θ value	0.00175202 (rank : 31)	NC score	0.395319 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	383	Shared Neighborhood Hits	37
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DDEF2_MOUSE
θ value	0.00228821 (rank : 32)	NC score	0.369260 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	625	Shared Neighborhood Hits	39
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GIT2_MOUSE
θ value	0.00665767 (rank : 33)	NC score	0.319408 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	323	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

CEND2_HUMAN
θ value	0.0113563 (rank : 34)	NC score	0.357714 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

DDFL1_HUMAN
θ value	0.0113563 (rank : 35)	NC score	0.398982 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	353	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
θ value	0.0148317 (rank : 36)	NC score	0.377536 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

GIT2_HUMAN
θ value	0.163984 (rank : 37)	NC score	0.309029 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	381	Shared Neighborhood Hits	38
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

MAGE1_HUMAN
θ value	0.163984 (rank : 38)	NC score	0.032573 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	1389	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PGCA_HUMAN
θ value	0.813845 (rank : 39)	NC score	0.033743 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	821	Shared Neighborhood Hits	16
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PICAL_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.025774 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q13492, O60700, Q86XZ9	Gene names	PICALM, CALM
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein).

IF35_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.035584 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

PDE4D_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.016742 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4D_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.016225 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PGCA_MOUSE
θ value	1.38821 (rank : 44)	NC score	0.035929 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	643	Shared Neighborhood Hits	15
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

ARNT_MOUSE
θ value	1.81305 (rank : 45)	NC score	0.020780 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

DAB2_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.026760 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

EYA4_HUMAN
θ value	1.81305 (rank : 47)	NC score	0.015386 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	O95677, O95464, O95679, Q8IW39, Q9NTR7	Gene names	EYA4
Domain Architecture
Description	Eyes absent homolog 4 (EC 3.1.3.48).

MEGF9_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.013695 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	557	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

NU153_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.060644 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

COE3_HUMAN
θ value	2.36792 (rank : 50)	NC score	0.015022 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4W6, Q5T6H9, Q9H4W5	Gene names	EBF3, COE3
Domain Architecture	No domain graphic available
Description	Transcription factor COE3 (Early B-cell factor 3) (EBF-3) (Olf-1/EBF- like 2) (OE-2) (O/E-2).

TS1R2_MOUSE
θ value	2.36792 (rank : 51)	NC score	0.014543 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q925I4, Q923J8	Gene names	Tas1r2, Gpr71, T1r2, Tr2
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 2 precursor (G-protein coupled receptor 71) (Sweet taste receptor T1R2).

EP15_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.010835 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	1021	Shared Neighborhood Hits	7
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

BUB1B_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.015784 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	202	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CREM_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.019335 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q03060, Q16114, Q16116, Q9NZB9	Gene names	CREM
Domain Architecture
Description	cAMP-responsive element modulator.

EPN1_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.035222 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

RSMN_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.034705 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.034705 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

GLI2_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.001407 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	971	Shared Neighborhood Hits	10
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

OSR1_MOUSE
θ value	5.27518 (rank : 59)	NC score	-0.001404 (rank : 84)
Query Neighborhood Hits	68	Target Neighborhood Hits	706	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVG7	Gene names	Osr1, Odd1
Domain Architecture	No domain graphic available
Description	Protein odd-skipped-related 1.

TNKS1_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.040989 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	477	Shared Neighborhood Hits	23
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

CEP68_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.033619 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	128	Shared Neighborhood Hits	4
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

HIRA_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.005426 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	P54198, Q8IXN2	Gene names	HIRA, DGCR1, HIR, TUPLE1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

P3H3_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.012913 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CG70, O88836	Gene names	Leprel2, P3h3
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 3 precursor (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B).

TFR1_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.013900 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

UBP5_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.017628 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.017630 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

GLI3_HUMAN
θ value	8.99809 (rank : 67)	NC score	-0.000448 (rank : 83)
Query Neighborhood Hits	68	Target Neighborhood Hits	871	Shared Neighborhood Hits	6
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

LY75_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.010543 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q60767, Q8C7T3, Q91XL8, Q9QUZ6	Gene names	Ly75, Cd205
Domain Architecture
Description	Lymphocyte antigen 75 precursor (DEC-205) (CD205 antigen).

ANR46_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.051785 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

CT086_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.055517 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	277	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

DP13A_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.056741 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.056599 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	96	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.050485 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.054454 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

ELN_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.058422 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P15502, O15336, O15337, Q14233, Q14234, Q14235, Q14238, Q6P0L4, Q6ZWJ6, Q75MU5, Q7Z316, Q7Z3F5, Q9UMF5	Gene names	ELN
Domain Architecture	No domain graphic available
Description	Elastin precursor (Tropoelastin).

ELN_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.056522 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	P54320	Gene names	Eln
Domain Architecture	No domain graphic available
Description	Elastin precursor (Tropoelastin).

GIT1_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.272846 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	336	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.272199 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	341	Shared Neighborhood Hits	33
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

OPHN1_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.061687 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.066449 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

PKHA1_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.056469 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.055573 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PYGO2_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.056663 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	189	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

RHG26_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.058406 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	281	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

Hits sorted by NC score

NUPL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
NC score	0.985829 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	113	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

HRBL_HUMAN
NC score	0.878232 (rank : 3)	θ value	2.48917e-58 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_MOUSE
NC score	0.847500 (rank : 4)	θ value	5.00389e-67 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	269	Shared Neighborhood Hits	44
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

SMAP1_HUMAN
NC score	0.651969 (rank : 5)	θ value	3.52202e-12 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
NC score	0.647527 (rank : 6)	θ value	3.52202e-12 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	120	Shared Neighborhood Hits	37
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_MOUSE
NC score	0.640016 (rank : 7)	θ value	3.89403e-11 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	70	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMP1L_HUMAN
NC score	0.639209 (rank : 8)	θ value	3.89403e-11 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

CENA1_HUMAN
NC score	0.614595 (rank : 9)	θ value	1.133e-10 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

ARFG1_HUMAN
NC score	0.589110 (rank : 10)	θ value	4.30538e-10 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENA2_MOUSE
NC score	0.577606 (rank : 11)	θ value	1.69304e-06 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

ARFG1_MOUSE
NC score	0.576834 (rank : 12)	θ value	9.92553e-07 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	51	Shared Neighborhood Hits	36
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENA2_HUMAN
NC score	0.566672 (rank : 13)	θ value	8.40245e-06 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	83	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ARFG3_HUMAN
NC score	0.528640 (rank : 14)	θ value	4.1701e-05 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
NC score	0.526127 (rank : 15)	θ value	1.09739e-05 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	80	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

CENG3_MOUSE
NC score	0.444022 (rank : 16)	θ value	2.61198e-07 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	467	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.443634 (rank : 17)	θ value	2.61198e-07 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	455	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG1_MOUSE
NC score	0.443573 (rank : 18)	θ value	3.77169e-06 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	531	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_MOUSE
NC score	0.440333 (rank : 19)	θ value	4.76016e-09 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	463	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG1_HUMAN
NC score	0.437593 (rank : 20)	θ value	4.92598e-06 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	544	Shared Neighborhood Hits	42
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG2_HUMAN
NC score	0.437143 (rank : 21)	θ value	1.38499e-08 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	471	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENB5_HUMAN
NC score	0.405287 (rank : 22)	θ value	3.77169e-06 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	395	Shared Neighborhood Hits	37
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

DDFL1_HUMAN
NC score	0.398982 (rank : 23)	θ value	0.0113563 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	353	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

CENB2_HUMAN
NC score	0.397499 (rank : 24)	θ value	2.21117e-06 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	425	Shared Neighborhood Hits	37
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB1_HUMAN
NC score	0.395319 (rank : 25)	θ value	0.00175202 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	383	Shared Neighborhood Hits	37
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DDEF1_MOUSE
NC score	0.386915 (rank : 26)	θ value	0.000786445 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	592	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CEND1_MOUSE
NC score	0.379255 (rank : 27)	θ value	4.1701e-05 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	260	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

DDFL1_MOUSE
NC score	0.377536 (rank : 28)	θ value	0.0148317 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DDEF2_HUMAN
NC score	0.377158 (rank : 29)	θ value	0.00134147 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	599	Shared Neighborhood Hits	38
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CEND1_HUMAN
NC score	0.375709 (rank : 30)	θ value	0.00020696 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	284	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND3_MOUSE
NC score	0.372094 (rank : 31)	θ value	9.29e-05 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.371707 (rank : 32)	θ value	0.000121331 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

DDEF2_MOUSE
NC score	0.369260 (rank : 33)	θ value	0.00228821 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	625	Shared Neighborhood Hits	39
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CEND2_HUMAN
NC score	0.357714 (rank : 34)	θ value	0.0113563 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

GIT2_MOUSE
NC score	0.319408 (rank : 35)	θ value	0.00665767 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	323	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_HUMAN
NC score	0.309029 (rank : 36)	θ value	0.163984 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	381	Shared Neighborhood Hits	38
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT1_HUMAN
NC score	0.272846 (rank : 37)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	336	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.272199 (rank : 38)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	341	Shared Neighborhood Hits	33
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

OPHN1_MOUSE
NC score	0.066449 (rank : 39)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_HUMAN
NC score	0.061687 (rank : 40)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

NU153_HUMAN
NC score	0.060644 (rank : 41)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

ELN_HUMAN
NC score	0.058422 (rank : 42)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P15502, O15336, O15337, Q14233, Q14234, Q14235, Q14238, Q6P0L4, Q6ZWJ6, Q75MU5, Q7Z316, Q7Z3F5, Q9UMF5	Gene names	ELN
Domain Architecture	No domain graphic available
Description	Elastin precursor (Tropoelastin).

RHG26_HUMAN
NC score	0.058406 (rank : 43)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	68	Target Neighborhood Hits	281	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

DP13A_HUMAN
NC score	0.056741 (rank : 44)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

PYGO2_HUMAN
NC score	0.056663 (rank : 45)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	68	Target Neighborhood Hits	189	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

DP13A_MOUSE
NC score	0.056599 (rank : 46)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	96	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

ELN_MOUSE
NC score	0.056522 (rank : 47)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	P54320	Gene names	Eln
Domain Architecture	No domain graphic available
Description	Elastin precursor (Tropoelastin).

PKHA1_HUMAN
NC score	0.056469 (rank : 48)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.055573 (rank : 49)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CT086_HUMAN
NC score	0.055517 (rank : 50)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	277	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

DP13B_MOUSE
NC score	0.054454 (rank : 51)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

GP112_HUMAN
NC score	0.054244 (rank : 52)	θ value	0.000270298 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	441	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

ANR46_HUMAN
NC score	0.051785 (rank : 53)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

DP13B_HUMAN
NC score	0.050485 (rank : 54)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

TNKS1_HUMAN
NC score	0.040989 (rank : 55)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	477	Shared Neighborhood Hits	23
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

PGCA_MOUSE
NC score	0.035929 (rank : 56)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	643	Shared Neighborhood Hits	15
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

IF35_MOUSE
NC score	0.035584 (rank : 57)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

EPN1_MOUSE
NC score	0.035222 (rank : 58)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	240	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

RSMN_HUMAN
NC score	0.034705 (rank : 59)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
NC score	0.034705 (rank : 60)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

PGCA_HUMAN
NC score	0.033743 (rank : 61)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	821	Shared Neighborhood Hits	16
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

CEP68_HUMAN
NC score	0.033619 (rank : 62)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	128	Shared Neighborhood Hits	4
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

MAGE1_HUMAN
NC score	0.032573 (rank : 63)	θ value	0.163984 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	1389	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

DAB2_HUMAN
NC score	0.026760 (rank : 64)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

PICAL_HUMAN
NC score	0.025774 (rank : 65)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q13492, O60700, Q86XZ9	Gene names	PICALM, CALM
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein).

ARNT_MOUSE
NC score	0.020780 (rank : 66)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CREM_HUMAN
NC score	0.019335 (rank : 67)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q03060, Q16114, Q16116, Q9NZB9	Gene names	CREM
Domain Architecture
Description	cAMP-responsive element modulator.

UBP5_MOUSE
NC score	0.017630 (rank : 68)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_HUMAN
NC score	0.017628 (rank : 69)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

PDE4D_MOUSE
NC score	0.016742 (rank : 70)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4D_HUMAN
NC score	0.016225 (rank : 71)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

BUB1B_MOUSE
NC score	0.015784 (rank : 72)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	202	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

EYA4_HUMAN
NC score	0.015386 (rank : 73)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	O95677, O95464, O95679, Q8IW39, Q9NTR7	Gene names	EYA4
Domain Architecture
Description	Eyes absent homolog 4 (EC 3.1.3.48).

COE3_HUMAN
NC score	0.015022 (rank : 74)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4W6, Q5T6H9, Q9H4W5	Gene names	EBF3, COE3
Domain Architecture	No domain graphic available
Description	Transcription factor COE3 (Early B-cell factor 3) (EBF-3) (Olf-1/EBF- like 2) (OE-2) (O/E-2).

TS1R2_MOUSE
NC score	0.014543 (rank : 75)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q925I4, Q923J8	Gene names	Tas1r2, Gpr71, T1r2, Tr2
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 2 precursor (G-protein coupled receptor 71) (Sweet taste receptor T1R2).

TFR1_MOUSE
NC score	0.013900 (rank : 76)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q62351, Q61560	Gene names	Tfrc, Trfr
Domain Architecture
Description	Transferrin receptor protein 1 (TfR1) (TR) (TfR) (Trfr) (CD71 antigen).

MEGF9_HUMAN
NC score	0.013695 (rank : 77)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	557	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

P3H3_MOUSE
NC score	0.012913 (rank : 78)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CG70, O88836	Gene names	Leprel2, P3h3
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 3 precursor (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B).

EP15_HUMAN
NC score	0.010835 (rank : 79)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	1021	Shared Neighborhood Hits	7
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

LY75_MOUSE
NC score	0.010543 (rank : 80)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	5
SwissProt Accessions	Q60767, Q8C7T3, Q91XL8, Q9QUZ6	Gene names	Ly75, Cd205
Domain Architecture
Description	Lymphocyte antigen 75 precursor (DEC-205) (CD205 antigen).

HIRA_HUMAN
NC score	0.005426 (rank : 81)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	P54198, Q8IXN2	Gene names	HIRA, DGCR1, HIR, TUPLE1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

GLI2_HUMAN
NC score	0.001407 (rank : 82)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	971	Shared Neighborhood Hits	10
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

GLI3_HUMAN
NC score	-0.000448 (rank : 83)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	871	Shared Neighborhood Hits	6
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

OSR1_MOUSE
NC score	-0.001404 (rank : 84)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	706	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVG7	Gene names	Osr1, Odd1
Domain Architecture	No domain graphic available
Description	Protein odd-skipped-related 1.