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Network neighborhood for query Sequence : OPHN1_MOUSE

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OPHN1_MOUSE
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

OPHN1_HUMAN
θ value	0 (rank : 1)	NC score	0.992647 (rank : 2)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	119
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	174	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG26_HUMAN
θ value	1.90485e-175 (rank : 3)	NC score	0.907613 (rank : 3)
Query Neighborhood Hits	174	Target Neighborhood Hits	281	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CHIO_MOUSE
θ value	1.57365e-28 (rank : 4)	NC score	0.759918 (rank : 12)
Query Neighborhood Hits	174	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_HUMAN
θ value	3.50572e-28 (rank : 5)	NC score	0.728915 (rank : 15)
Query Neighborhood Hits	174	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
θ value	2.96777e-27 (rank : 6)	NC score	0.727822 (rank : 16)
Query Neighborhood Hits	174	Target Neighborhood Hits	229	Shared Neighborhood Hits	63
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
θ value	5.06226e-27 (rank : 7)	NC score	0.726686 (rank : 17)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG12_HUMAN
θ value	2.77775e-25 (rank : 8)	NC score	0.779594 (rank : 5)
Query Neighborhood Hits	174	Target Neighborhood Hits	190	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	6.18819e-25 (rank : 9)	NC score	0.778379 (rank : 6)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GRLF1_HUMAN
θ value	2.59989e-23 (rank : 10)	NC score	0.764068 (rank : 11)
Query Neighborhood Hits	174	Target Neighborhood Hits	167	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

RHG09_HUMAN
θ value	3.75424e-22 (rank : 11)	NC score	0.806950 (rank : 4)
Query Neighborhood Hits	174	Target Neighborhood Hits	186	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

GMIP_MOUSE
θ value	1.2077e-20 (rank : 12)	NC score	0.772354 (rank : 7)
Query Neighborhood Hits	174	Target Neighborhood Hits	202	Shared Neighborhood Hits	68
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG05_HUMAN
θ value	1.74391e-19 (rank : 13)	NC score	0.725524 (rank : 18)
Query Neighborhood Hits	174	Target Neighborhood Hits	158	Shared Neighborhood Hits	69
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

CENB5_HUMAN
θ value	2.27762e-19 (rank : 14)	NC score	0.286031 (rank : 66)
Query Neighborhood Hits	174	Target Neighborhood Hits	395	Shared Neighborhood Hits	28
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

RHG05_MOUSE
θ value	2.97466e-19 (rank : 15)	NC score	0.729187 (rank : 14)
Query Neighborhood Hits	174	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

TCGAP_HUMAN
θ value	3.88503e-19 (rank : 16)	NC score	0.644684 (rank : 40)
Query Neighborhood Hits	174	Target Neighborhood Hits	872	Shared Neighborhood Hits	70
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	5.07402e-19 (rank : 17)	NC score	0.724562 (rank : 19)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	66
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

FNBP2_HUMAN
θ value	1.13037e-18 (rank : 18)	NC score	0.657477 (rank : 37)
Query Neighborhood Hits	174	Target Neighborhood Hits	432	Shared Neighborhood Hits	88
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GMIP_HUMAN
θ value	1.92812e-18 (rank : 19)	NC score	0.764328 (rank : 10)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	66
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RGAP1_HUMAN
θ value	5.60996e-18 (rank : 20)	NC score	0.770196 (rank : 8)
Query Neighborhood Hits	174	Target Neighborhood Hits	189	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	3.63628e-17 (rank : 21)	NC score	0.767090 (rank : 9)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

SRGP1_HUMAN
θ value	3.63628e-17 (rank : 22)	NC score	0.659870 (rank : 36)
Query Neighborhood Hits	174	Target Neighborhood Hits	390	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	8.10077e-17 (rank : 23)	NC score	0.667656 (rank : 31)
Query Neighborhood Hits	174	Target Neighborhood Hits	331	Shared Neighborhood Hits	72
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

MYO9B_HUMAN
θ value	1.38178e-16 (rank : 24)	NC score	0.404975 (rank : 58)
Query Neighborhood Hits	174	Target Neighborhood Hits	641	Shared Neighborhood Hits	82
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

RHG01_HUMAN
θ value	1.38178e-16 (rank : 25)	NC score	0.719106 (rank : 21)
Query Neighborhood Hits	174	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

SRGP2_MOUSE
θ value	1.80466e-16 (rank : 26)	NC score	0.660795 (rank : 35)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	74
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

MYO9B_MOUSE
θ value	2.35696e-16 (rank : 27)	NC score	0.410653 (rank : 57)
Query Neighborhood Hits	174	Target Neighborhood Hits	311	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CENB2_HUMAN
θ value	1.16975e-15 (rank : 28)	NC score	0.288718 (rank : 65)
Query Neighborhood Hits	174	Target Neighborhood Hits	425	Shared Neighborhood Hits	32
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

ABR_HUMAN
θ value	1.52774e-15 (rank : 29)	NC score	0.678798 (rank : 28)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG04_HUMAN
θ value	2.60593e-15 (rank : 30)	NC score	0.675805 (rank : 30)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

BCR_HUMAN
θ value	7.58209e-15 (rank : 31)	NC score	0.667640 (rank : 32)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

DP13A_HUMAN
θ value	2.20605e-14 (rank : 32)	NC score	0.370453 (rank : 59)
Query Neighborhood Hits	174	Target Neighborhood Hits	107	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

3BP1_HUMAN
θ value	3.76295e-14 (rank : 33)	NC score	0.724331 (rank : 20)
Query Neighborhood Hits	174	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CENB1_HUMAN
θ value	6.41864e-14 (rank : 34)	NC score	0.270557 (rank : 69)
Query Neighborhood Hits	174	Target Neighborhood Hits	383	Shared Neighborhood Hits	26
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DP13A_MOUSE
θ value	1.42992e-13 (rank : 35)	NC score	0.367222 (rank : 60)
Query Neighborhood Hits	174	Target Neighborhood Hits	96	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

CEND2_HUMAN
θ value	5.43371e-13 (rank : 36)	NC score	0.645277 (rank : 39)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RBP1_MOUSE
θ value	1.2105e-12 (rank : 37)	NC score	0.676053 (rank : 29)
Query Neighborhood Hits	174	Target Neighborhood Hits	493	Shared Neighborhood Hits	95
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_HUMAN
θ value	3.52202e-12 (rank : 38)	NC score	0.660960 (rank : 34)
Query Neighborhood Hits	174	Target Neighborhood Hits	521	Shared Neighborhood Hits	101
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_MOUSE
θ value	6.00763e-12 (rank : 39)	NC score	0.667106 (rank : 33)
Query Neighborhood Hits	174	Target Neighborhood Hits	492	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

3BP1_MOUSE
θ value	7.84624e-12 (rank : 40)	NC score	0.736106 (rank : 13)
Query Neighborhood Hits	174	Target Neighborhood Hits	238	Shared Neighborhood Hits	66
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

DP13B_MOUSE
θ value	7.84624e-12 (rank : 41)	NC score	0.347783 (rank : 63)
Query Neighborhood Hits	174	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

RHG07_MOUSE
θ value	1.74796e-11 (rank : 42)	NC score	0.622149 (rank : 41)
Query Neighborhood Hits	174	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG08_MOUSE
θ value	1.74796e-11 (rank : 43)	NC score	0.696699 (rank : 26)
Query Neighborhood Hits	174	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CEND3_MOUSE
θ value	2.28291e-11 (rank : 44)	NC score	0.600676 (rank : 45)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

RHG08_HUMAN
θ value	2.28291e-11 (rank : 45)	NC score	0.692989 (rank : 27)
Query Neighborhood Hits	174	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CEND3_HUMAN
θ value	3.89403e-11 (rank : 46)	NC score	0.592279 (rank : 46)
Query Neighborhood Hits	174	Target Neighborhood Hits	275	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

RHG07_HUMAN
θ value	3.89403e-11 (rank : 47)	NC score	0.617663 (rank : 42)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG25_HUMAN
θ value	5.08577e-11 (rank : 48)	NC score	0.652195 (rank : 38)
Query Neighborhood Hits	174	Target Neighborhood Hits	550	Shared Neighborhood Hits	97
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG06_HUMAN
θ value	8.67504e-11 (rank : 49)	NC score	0.718867 (rank : 22)
Query Neighborhood Hits	174	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG18_HUMAN
θ value	1.133e-10 (rank : 50)	NC score	0.709029 (rank : 24)
Query Neighborhood Hits	174	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG06_MOUSE
θ value	2.52405e-10 (rank : 51)	NC score	0.716966 (rank : 23)
Query Neighborhood Hits	174	Target Neighborhood Hits	105	Shared Neighborhood Hits	62
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

DP13B_HUMAN
θ value	4.30538e-10 (rank : 52)	NC score	0.337092 (rank : 64)
Query Neighborhood Hits	174	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CEND1_MOUSE
θ value	5.62301e-10 (rank : 53)	NC score	0.557506 (rank : 53)
Query Neighborhood Hits	174	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CE005_HUMAN
θ value	7.34386e-10 (rank : 54)	NC score	0.590190 (rank : 47)
Query Neighborhood Hits	174	Target Neighborhood Hits	213	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
θ value	7.34386e-10 (rank : 55)	NC score	0.588871 (rank : 48)
Query Neighborhood Hits	174	Target Neighborhood Hits	238	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CEND1_HUMAN
θ value	2.13673e-09 (rank : 56)	NC score	0.536703 (rank : 54)
Query Neighborhood Hits	174	Target Neighborhood Hits	284	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RHG18_MOUSE
θ value	2.13673e-09 (rank : 57)	NC score	0.697045 (rank : 25)
Query Neighborhood Hits	174	Target Neighborhood Hits	110	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

STA13_HUMAN
θ value	1.06045e-08 (rank : 58)	NC score	0.575899 (rank : 49)
Query Neighborhood Hits	174	Target Neighborhood Hits	89	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
θ value	6.87365e-08 (rank : 59)	NC score	0.564423 (rank : 52)
Query Neighborhood Hits	174	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

STAR8_HUMAN
θ value	2.61198e-07 (rank : 60)	NC score	0.568100 (rank : 51)
Query Neighborhood Hits	174	Target Neighborhood Hits	216	Shared Neighborhood Hits	61
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_MOUSE
θ value	5.81887e-07 (rank : 61)	NC score	0.573282 (rank : 50)
Query Neighborhood Hits	174	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

DDEF2_HUMAN
θ value	2.88788e-06 (rank : 62)	NC score	0.215995 (rank : 70)
Query Neighborhood Hits	174	Target Neighborhood Hits	599	Shared Neighborhood Hits	34
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

P85A_HUMAN
θ value	6.43352e-06 (rank : 63)	NC score	0.364619 (rank : 61)
Query Neighborhood Hits	174	Target Neighborhood Hits	479	Shared Neighborhood Hits	87
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DDEF2_MOUSE
θ value	8.40245e-06 (rank : 64)	NC score	0.212972 (rank : 71)
Query Neighborhood Hits	174	Target Neighborhood Hits	625	Shared Neighborhood Hits	35
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

TAGAP_HUMAN
θ value	8.40245e-06 (rank : 65)	NC score	0.615804 (rank : 43)
Query Neighborhood Hits	174	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

K1688_MOUSE
θ value	2.44474e-05 (rank : 66)	NC score	0.497552 (rank : 55)
Query Neighborhood Hits	174	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

P85A_MOUSE
θ value	2.44474e-05 (rank : 67)	NC score	0.357746 (rank : 62)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DDEF1_MOUSE
θ value	5.44631e-05 (rank : 68)	NC score	0.203230 (rank : 72)
Query Neighborhood Hits	174	Target Neighborhood Hits	592	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

K1688_HUMAN
θ value	5.44631e-05 (rank : 69)	NC score	0.483880 (rank : 56)
Query Neighborhood Hits	174	Target Neighborhood Hits	217	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

TAGAP_MOUSE
θ value	0.000121331 (rank : 70)	NC score	0.613719 (rank : 44)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

DDFL1_HUMAN
θ value	0.000461057 (rank : 71)	NC score	0.191845 (rank : 73)
Query Neighborhood Hits	174	Target Neighborhood Hits	353	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

CT2NL_HUMAN
θ value	0.00228821 (rank : 72)	NC score	0.062897 (rank : 119)
Query Neighborhood Hits	174	Target Neighborhood Hits	1059	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

DDFL1_MOUSE
θ value	0.0193708 (rank : 73)	NC score	0.171321 (rank : 74)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	20
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

OCRL_HUMAN
θ value	0.0252991 (rank : 74)	NC score	0.283732 (rank : 67)
Query Neighborhood Hits	174	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

LRC45_HUMAN
θ value	0.0431538 (rank : 75)	NC score	0.043064 (rank : 204)
Query Neighborhood Hits	174	Target Neighborhood Hits	933	Shared Neighborhood Hits	50
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MYH6_MOUSE
θ value	0.0563607 (rank : 76)	NC score	0.054250 (rank : 163)
Query Neighborhood Hits	174	Target Neighborhood Hits	1501	Shared Neighborhood Hits	76
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYO5A_HUMAN
θ value	0.0563607 (rank : 77)	NC score	0.059872 (rank : 128)
Query Neighborhood Hits	174	Target Neighborhood Hits	1092	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

ANGP2_HUMAN
θ value	0.0736092 (rank : 78)	NC score	0.025853 (rank : 238)
Query Neighborhood Hits	174	Target Neighborhood Hits	400	Shared Neighborhood Hits	41
SwissProt Accessions	O15123, Q9NRR7, Q9P2Y7	Gene names	ANGPT2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

EP400_MOUSE
θ value	0.0736092 (rank : 79)	NC score	0.030521 (rank : 227)
Query Neighborhood Hits	174	Target Neighborhood Hits	592	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

MYH6_HUMAN
θ value	0.0736092 (rank : 80)	NC score	0.053285 (rank : 172)
Query Neighborhood Hits	174	Target Neighborhood Hits	1426	Shared Neighborhood Hits	72
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYO5A_MOUSE
θ value	0.0961366 (rank : 81)	NC score	0.061109 (rank : 124)
Query Neighborhood Hits	174	Target Neighborhood Hits	1117	Shared Neighborhood Hits	61
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

RPB5_HUMAN
θ value	0.0961366 (rank : 82)	NC score	0.084116 (rank : 96)
Query Neighborhood Hits	174	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P19388, O43380, Q6PIH5, Q9BT06	Gene names	POLR2E
Domain Architecture
Description	DNA-directed RNA polymerase II 23 kDa polypeptide (EC 2.7.7.6) (RPB25) (RPB5) (RPABC1) (XAP4).

RPB5_MOUSE
θ value	0.0961366 (rank : 83)	NC score	0.083607 (rank : 97)
Query Neighborhood Hits	174	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q80UW8	Gene names	Polr2e
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase II 23 kDa polypeptide (EC 2.7.7.6) (RPB25) (RPB5) (RPABC1).

RAD50_HUMAN
θ value	0.125558 (rank : 84)	NC score	0.049880 (rank : 196)
Query Neighborhood Hits	174	Target Neighborhood Hits	1317	Shared Neighborhood Hits	68
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

MIPO1_HUMAN
θ value	0.279714 (rank : 85)	NC score	0.049961 (rank : 195)
Query Neighborhood Hits	174	Target Neighborhood Hits	486	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

BICD1_MOUSE
θ value	0.47712 (rank : 86)	NC score	0.045667 (rank : 198)
Query Neighborhood Hits	174	Target Neighborhood Hits	837	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CR034_MOUSE
θ value	0.47712 (rank : 87)	NC score	0.048471 (rank : 197)
Query Neighborhood Hits	174	Target Neighborhood Hits	643	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

RAD50_MOUSE
θ value	0.47712 (rank : 88)	NC score	0.050692 (rank : 189)
Query Neighborhood Hits	174	Target Neighborhood Hits	1366	Shared Neighborhood Hits	72
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

CP135_HUMAN
θ value	0.62314 (rank : 89)	NC score	0.040632 (rank : 210)
Query Neighborhood Hits	174	Target Neighborhood Hits	1290	Shared Neighborhood Hits	68
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

M3K13_HUMAN
θ value	0.62314 (rank : 90)	NC score	-0.003880 (rank : 278)
Query Neighborhood Hits	174	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

SYCP1_HUMAN
θ value	0.62314 (rank : 91)	NC score	0.044538 (rank : 201)
Query Neighborhood Hits	174	Target Neighborhood Hits	1313	Shared Neighborhood Hits	68
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

BICD1_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.042153 (rank : 207)
Query Neighborhood Hits	174	Target Neighborhood Hits	844	Shared Neighborhood Hits	61
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CE290_HUMAN
θ value	0.813845 (rank : 93)	NC score	0.043675 (rank : 203)
Query Neighborhood Hits	174	Target Neighborhood Hits	1553	Shared Neighborhood Hits	71
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CP250_HUMAN
θ value	0.813845 (rank : 94)	NC score	0.039067 (rank : 213)
Query Neighborhood Hits	174	Target Neighborhood Hits	1805	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CT096_HUMAN
θ value	0.813845 (rank : 95)	NC score	0.040787 (rank : 209)
Query Neighborhood Hits	174	Target Neighborhood Hits	438	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

FA47B_HUMAN
θ value	0.813845 (rank : 96)	NC score	0.020963 (rank : 248)
Query Neighborhood Hits	174	Target Neighborhood Hits	431	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MCPH1_MOUSE
θ value	0.813845 (rank : 97)	NC score	0.022146 (rank : 244)
Query Neighborhood Hits	174	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

MY18A_MOUSE
θ value	0.813845 (rank : 98)	NC score	0.056680 (rank : 147)
Query Neighborhood Hits	174	Target Neighborhood Hits	1989	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CCD46_HUMAN
θ value	1.06291 (rank : 99)	NC score	0.045068 (rank : 199)
Query Neighborhood Hits	174	Target Neighborhood Hits	1430	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

GP153_HUMAN
θ value	1.06291 (rank : 100)	NC score	0.018363 (rank : 252)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

CCD39_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.035092 (rank : 222)
Query Neighborhood Hits	174	Target Neighborhood Hits	868	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CYTSA_HUMAN
θ value	1.38821 (rank : 102)	NC score	0.037640 (rank : 216)
Query Neighborhood Hits	174	Target Neighborhood Hits	1138	Shared Neighborhood Hits	62
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

PSL1_HUMAN
θ value	1.38821 (rank : 103)	NC score	0.019512 (rank : 251)
Query Neighborhood Hits	174	Target Neighborhood Hits	650	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

TPR_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.040233 (rank : 212)
Query Neighborhood Hits	174	Target Neighborhood Hits	1921	Shared Neighborhood Hits	74
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CCHCR_MOUSE
θ value	1.81305 (rank : 105)	NC score	0.035867 (rank : 219)
Query Neighborhood Hits	174	Target Neighborhood Hits	932	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

LUZP1_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.040239 (rank : 211)
Query Neighborhood Hits	174	Target Neighborhood Hits	739	Shared Neighborhood Hits	51
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

RUFY2_HUMAN
θ value	1.81305 (rank : 107)	NC score	0.030585 (rank : 226)
Query Neighborhood Hits	174	Target Neighborhood Hits	1208	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TRI37_HUMAN
θ value	1.81305 (rank : 108)	NC score	0.021137 (rank : 246)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	1.81305 (rank : 109)	NC score	0.021086 (rank : 247)
Query Neighborhood Hits	174	Target Neighborhood Hits	316	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

A20A2_HUMAN
θ value	2.36792 (rank : 110)	NC score	0.027672 (rank : 233)
Query Neighborhood Hits	174	Target Neighborhood Hits	716	Shared Neighborhood Hits	51
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

COG7_HUMAN
θ value	2.36792 (rank : 111)	NC score	0.030432 (rank : 228)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	P83436, Q6UWU7	Gene names	COG7
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 7.

GEMI5_MOUSE
θ value	2.36792 (rank : 112)	NC score	0.012160 (rank : 260)
Query Neighborhood Hits	174	Target Neighborhood Hits	424	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

JIP2_HUMAN
θ value	2.36792 (rank : 113)	NC score	0.025444 (rank : 239)
Query Neighborhood Hits	174	Target Neighborhood Hits	288	Shared Neighborhood Hits	15
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

KIF4A_HUMAN
θ value	2.36792 (rank : 114)	NC score	0.025953 (rank : 237)
Query Neighborhood Hits	174	Target Neighborhood Hits	1159	Shared Neighborhood Hits	64
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MAST4_HUMAN
θ value	2.36792 (rank : 115)	NC score	-0.000200 (rank : 276)
Query Neighborhood Hits	174	Target Neighborhood Hits	1804	Shared Neighborhood Hits	32
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MYH13_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.050741 (rank : 188)
Query Neighborhood Hits	174	Target Neighborhood Hits	1504	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH14_MOUSE
θ value	2.36792 (rank : 117)	NC score	0.050112 (rank : 193)
Query Neighborhood Hits	174	Target Neighborhood Hits	1225	Shared Neighborhood Hits	61
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

SH3G2_MOUSE
θ value	2.36792 (rank : 118)	NC score	0.058350 (rank : 136)
Query Neighborhood Hits	174	Target Neighborhood Hits	319	Shared Neighborhood Hits	25
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ANR11_HUMAN
θ value	3.0926 (rank : 119)	NC score	0.028896 (rank : 232)
Query Neighborhood Hits	174	Target Neighborhood Hits	1289	Shared Neighborhood Hits	63
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ARHG8_MOUSE
θ value	3.0926 (rank : 120)	NC score	0.020365 (rank : 250)
Query Neighborhood Hits	174	Target Neighborhood Hits	79	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

CENPF_HUMAN
θ value	3.0926 (rank : 121)	NC score	0.044537 (rank : 202)
Query Neighborhood Hits	174	Target Neighborhood Hits	1932	Shared Neighborhood Hits	87
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CK5P2_HUMAN
θ value	3.0926 (rank : 122)	NC score	0.038599 (rank : 214)
Query Neighborhood Hits	174	Target Neighborhood Hits	1433	Shared Neighborhood Hits	73
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CP135_MOUSE
θ value	3.0926 (rank : 123)	NC score	0.035911 (rank : 218)
Query Neighborhood Hits	174	Target Neighborhood Hits	1278	Shared Neighborhood Hits	68
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

FER_HUMAN
θ value	3.0926 (rank : 124)	NC score	0.014391 (rank : 255)
Query Neighborhood Hits	174	Target Neighborhood Hits	1278	Shared Neighborhood Hits	51
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

K6PF_HUMAN
θ value	3.0926 (rank : 125)	NC score	0.011044 (rank : 263)
Query Neighborhood Hits	174	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P08237, Q16814, Q16815	Gene names	PFKM
Domain Architecture
Description	6-phosphofructokinase, muscle type (EC 2.7.1.11) (Phosphofructokinase 1) (Phosphohexokinase) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphofructokinase-M).

NEBU_HUMAN
θ value	3.0926 (rank : 126)	NC score	0.042525 (rank : 206)
Query Neighborhood Hits	174	Target Neighborhood Hits	420	Shared Neighborhood Hits	30
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

REST_MOUSE
θ value	3.0926 (rank : 127)	NC score	0.036039 (rank : 217)
Query Neighborhood Hits	174	Target Neighborhood Hits	1506	Shared Neighborhood Hits	75
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

T22D4_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.012009 (rank : 261)
Query Neighborhood Hits	174	Target Neighborhood Hits	403	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

TNNT1_MOUSE
θ value	3.0926 (rank : 129)	NC score	0.027153 (rank : 235)
Query Neighborhood Hits	174	Target Neighborhood Hits	212	Shared Neighborhood Hits	31
SwissProt Accessions	O88346, O88795, Q9QUP7	Gene names	Tnnt1
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

TTC28_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.013621 (rank : 257)
Query Neighborhood Hits	174	Target Neighborhood Hits	271	Shared Neighborhood Hits	7
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

VATH_HUMAN
θ value	3.0926 (rank : 131)	NC score	0.024146 (rank : 241)
Query Neighborhood Hits	174	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UI12, Q6PK44, Q9H3E3, Q9Y300	Gene names	ATP6V1H
Domain Architecture
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit SFD) (VMA13) (Nef-binding protein 1) (NBP1).

VATH_MOUSE
θ value	3.0926 (rank : 132)	NC score	0.024177 (rank : 240)
Query Neighborhood Hits	174	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BVE3, Q921X8	Gene names	Atp6v1h
Domain Architecture	No domain graphic available
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H).

ARHGC_HUMAN
θ value	4.03905 (rank : 133)	NC score	0.005396 (rank : 275)
Query Neighborhood Hits	174	Target Neighborhood Hits	351	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CYTSA_MOUSE
θ value	4.03905 (rank : 134)	NC score	0.038464 (rank : 215)
Query Neighborhood Hits	174	Target Neighborhood Hits	1104	Shared Neighborhood Hits	64
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

MYH11_MOUSE
θ value	4.03905 (rank : 135)	NC score	0.054019 (rank : 166)
Query Neighborhood Hits	174	Target Neighborhood Hits	1777	Shared Neighborhood Hits	84
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

RBCC1_MOUSE
θ value	4.03905 (rank : 136)	NC score	0.033639 (rank : 223)
Query Neighborhood Hits	174	Target Neighborhood Hits	1048	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RUFY2_MOUSE
θ value	4.03905 (rank : 137)	NC score	0.032601 (rank : 224)
Query Neighborhood Hits	174	Target Neighborhood Hits	820	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TXLNB_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.035726 (rank : 220)
Query Neighborhood Hits	174	Target Neighborhood Hits	912	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

CKAP2_HUMAN
θ value	5.27518 (rank : 139)	NC score	0.011195 (rank : 262)
Query Neighborhood Hits	174	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWK9, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4	Gene names	CKAP2, LB1, TMAP
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2 (Tumor-associated microtubule- associated protein) (CTCL tumor antigen se20-10).

HN1L_HUMAN
θ value	5.27518 (rank : 140)	NC score	0.016826 (rank : 253)
Query Neighborhood Hits	174	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

I5P2_HUMAN
θ value	5.27518 (rank : 141)	NC score	0.276923 (rank : 68)
Query Neighborhood Hits	174	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

K6PL_HUMAN
θ value	5.27518 (rank : 142)	NC score	0.009996 (rank : 267)
Query Neighborhood Hits	174	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P17858, Q96A64, Q96IH4, Q9BR91	Gene names	PFKL
Domain Architecture
Description	6-phosphofructokinase, liver type (EC 2.7.1.11) (Phosphofructokinase 1) (Phosphohexokinase) (Phosphofructo-1-kinase isozyme B) (PFK-B).

MMRN1_HUMAN
θ value	5.27518 (rank : 143)	NC score	0.026969 (rank : 236)
Query Neighborhood Hits	174	Target Neighborhood Hits	636	Shared Neighborhood Hits	44
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

MYH11_HUMAN
θ value	5.27518 (rank : 144)	NC score	0.053321 (rank : 171)
Query Neighborhood Hits	174	Target Neighborhood Hits	1806	Shared Neighborhood Hits	84
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

SH3G2_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.054871 (rank : 160)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

WWP1_HUMAN
θ value	5.27518 (rank : 146)	NC score	0.010665 (rank : 265)
Query Neighborhood Hits	174	Target Neighborhood Hits	262	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ZN467_MOUSE
θ value	5.27518 (rank : 147)	NC score	-0.006956 (rank : 279)
Query Neighborhood Hits	174	Target Neighborhood Hits	794	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZL0, Q9JJ98	Gene names	Znf467, Ezi, Zfp467
Domain Architecture	No domain graphic available
Description	Zinc finger protein 467 (Endothelial cell-derived zinc finger protein) (EZI).

ARP8_MOUSE
θ value	6.88961 (rank : 148)	NC score	0.007002 (rank : 272)
Query Neighborhood Hits	174	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R2S9, Q9CYC4	Gene names	Actr8
Domain Architecture
Description	Actin-related protein 8.

CT2NL_MOUSE
θ value	6.88961 (rank : 149)	NC score	0.035610 (rank : 221)
Query Neighborhood Hits	174	Target Neighborhood Hits	902	Shared Neighborhood Hits	56
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

EXOC3_MOUSE
θ value	6.88961 (rank : 150)	NC score	0.013788 (rank : 256)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q6KAR6	Gene names	Exoc3, Sec6l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 3 (Exocyst complex component Sec6).

HS74L_HUMAN
θ value	6.88961 (rank : 151)	NC score	0.005535 (rank : 274)
Query Neighborhood Hits	174	Target Neighborhood Hits	141	Shared Neighborhood Hits	13
SwissProt Accessions	O95757, Q4W5M5, Q8IWA2	Gene names	HSPA4L, APG1, OSP94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

HS74L_MOUSE
θ value	6.88961 (rank : 152)	NC score	0.006495 (rank : 273)
Query Neighborhood Hits	174	Target Neighborhood Hits	141	Shared Neighborhood Hits	10
SwissProt Accessions	P48722, P97854, Q8BQD0, Q8CC45, Q91X29	Gene names	Hspa4l, Apg1, Hsp4l, Osp94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

PICK1_MOUSE
θ value	6.88961 (rank : 153)	NC score	0.023692 (rank : 242)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

RADI_MOUSE
θ value	6.88961 (rank : 154)	NC score	0.023448 (rank : 243)
Query Neighborhood Hits	174	Target Neighborhood Hits	773	Shared Neighborhood Hits	51
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

SNIP_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.010730 (rank : 264)
Query Neighborhood Hits	174	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

TTC28_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.013534 (rank : 258)
Query Neighborhood Hits	174	Target Neighborhood Hits	194	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

AFF1_MOUSE
θ value	8.99809 (rank : 157)	NC score	0.009260 (rank : 268)
Query Neighborhood Hits	174	Target Neighborhood Hits	351	Shared Neighborhood Hits	11
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

BOC_HUMAN
θ value	8.99809 (rank : 158)	NC score	-0.002618 (rank : 277)
Query Neighborhood Hits	174	Target Neighborhood Hits	543	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CAYP2_MOUSE
θ value	8.99809 (rank : 159)	NC score	0.007429 (rank : 270)
Query Neighborhood Hits	174	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BUG5, Q8C1J6	Gene names	Caps2
Domain Architecture	No domain graphic available
Description	Calcyphosin-2 (Calcyphosine-2).

CCD46_MOUSE
θ value	8.99809 (rank : 160)	NC score	0.042753 (rank : 205)
Query Neighborhood Hits	174	Target Neighborhood Hits	1405	Shared Neighborhood Hits	75
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CK036_HUMAN
θ value	8.99809 (rank : 161)	NC score	0.014884 (rank : 254)
Query Neighborhood Hits	174	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q2M3A8, Q6TF48, Q8N7R8, Q8N9X7	Gene names	C11orf36
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf36.

DIAP3_MOUSE
θ value	8.99809 (rank : 162)	NC score	0.008876 (rank : 269)
Query Neighborhood Hits	174	Target Neighborhood Hits	221	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z207	Gene names	Diaph3, Diap3
Domain Architecture
Description	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2).

K0776_HUMAN
θ value	8.99809 (rank : 163)	NC score	0.007083 (rank : 271)
Query Neighborhood Hits	174	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	O94874, Q8N765, Q9NTQ0	Gene names	KIAA0776
Domain Architecture	No domain graphic available
Description	Protein KIAA0776.

MACF1_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.020799 (rank : 249)
Query Neighborhood Hits	174	Target Neighborhood Hits	1341	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

PRP40_HUMAN
θ value	8.99809 (rank : 165)	NC score	0.044555 (rank : 200)
Query Neighborhood Hits	174	Target Neighborhood Hits	442	Shared Neighborhood Hits	30
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	8.99809 (rank : 166)	NC score	0.040830 (rank : 208)
Query Neighborhood Hits	174	Target Neighborhood Hits	447	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

SMC3_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.029190 (rank : 230)
Query Neighborhood Hits	174	Target Neighborhood Hits	1186	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.029662 (rank : 229)
Query Neighborhood Hits	174	Target Neighborhood Hits	1187	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SYNE1_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.031024 (rank : 225)
Query Neighborhood Hits	174	Target Neighborhood Hits	1484	Shared Neighborhood Hits	73
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TNNT1_HUMAN
θ value	8.99809 (rank : 170)	NC score	0.021314 (rank : 245)
Query Neighborhood Hits	174	Target Neighborhood Hits	211	Shared Neighborhood Hits	26
SwissProt Accessions	P13805, O95472, Q16061	Gene names	TNNT1, TNT
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

TNNT3_HUMAN
θ value	8.99809 (rank : 171)	NC score	0.028936 (rank : 231)
Query Neighborhood Hits	174	Target Neighborhood Hits	327	Shared Neighborhood Hits	41
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

TNNT3_MOUSE
θ value	8.99809 (rank : 172)	NC score	0.027433 (rank : 234)
Query Neighborhood Hits	174	Target Neighborhood Hits	317	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZ47, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46	Gene names	Tnnt3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT).

TPX2_HUMAN
θ value	8.99809 (rank : 173)	NC score	0.012925 (rank : 259)
Query Neighborhood Hits	174	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULW0, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1	Gene names	TPX2, C20orf1, C20orf2, DIL2, HCA519
Domain Architecture	No domain graphic available
Description	Targeting protein for Xklp2 (Restricted expression proliferation- associated protein 100) (p100) (Differentially expressed in cancerous and noncancerous lung cells 2) (DIL-2) (Protein FLS353) (Hepatocellular carcinoma-associated antigen 519).

VATD_MOUSE
θ value	8.99809 (rank : 174)	NC score	0.010222 (rank : 266)
Query Neighborhood Hits	174	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P57746	Gene names	Atp6v1d, Atp6m, Vatd
Domain Architecture
Description	Vacuolar ATP synthase subunit D (EC 3.6.3.14) (V-ATPase D subunit) (Vacuolar proton pump D subunit) (V-ATPase 28 kDa accessory protein).

ABI1_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.051723 (rank : 183)
Query Neighborhood Hits	174	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.058708 (rank : 132)
Query Neighborhood Hits	174	Target Neighborhood Hits	350	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.058690 (rank : 133)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	17
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ARFG1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.111631 (rank : 85)
Query Neighborhood Hits	174	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.116540 (rank : 81)
Query Neighborhood Hits	174	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.112969 (rank : 83)
Query Neighborhood Hits	174	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.112508 (rank : 84)
Query Neighborhood Hits	174	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARHG7_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.050343 (rank : 191)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CD2AP_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.062765 (rank : 120)
Query Neighborhood Hits	174	Target Neighborhood Hits	315	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.055004 (rank : 158)
Query Neighborhood Hits	174	Target Neighborhood Hits	336	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CENA1_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.120436 (rank : 78)
Query Neighborhood Hits	174	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.117982 (rank : 80)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.113636 (rank : 82)
Query Neighborhood Hits	174	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENG1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.101262 (rank : 88)
Query Neighborhood Hits	174	Target Neighborhood Hits	544	Shared Neighborhood Hits	20
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.103583 (rank : 87)
Query Neighborhood Hits	174	Target Neighborhood Hits	531	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.087809 (rank : 92)
Query Neighborhood Hits	174	Target Neighborhood Hits	471	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.088020 (rank : 91)
Query Neighborhood Hits	174	Target Neighborhood Hits	463	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG3_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.093776 (rank : 90)
Query Neighborhood Hits	174	Target Neighborhood Hits	455	Shared Neighborhood Hits	15
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.094986 (rank : 89)
Query Neighborhood Hits	174	Target Neighborhood Hits	467	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CIP4_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.070630 (rank : 104)
Query Neighborhood Hits	174	Target Neighborhood Hits	374	Shared Neighborhood Hits	41
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRKL_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.051188 (rank : 186)
Query Neighborhood Hits	174	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.067404 (rank : 105)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.071510 (rank : 102)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKD_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.050321 (rank : 192)
Query Neighborhood Hits	174	Target Neighborhood Hits	231	Shared Neighborhood Hits	21
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.055805 (rank : 152)
Query Neighborhood Hits	174	Target Neighborhood Hits	255	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DNMBP_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.053929 (rank : 167)
Query Neighborhood Hits	174	Target Neighborhood Hits	413	Shared Neighborhood Hits	30
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.050975 (rank : 187)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	37
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FA13A_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.058292 (rank : 138)
Query Neighborhood Hits	174	Target Neighborhood Hits	102	Shared Neighborhood Hits	12
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

FA13A_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.058055 (rank : 140)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

GIT1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.084970 (rank : 95)
Query Neighborhood Hits	174	Target Neighborhood Hits	336	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.083128 (rank : 98)
Query Neighborhood Hits	174	Target Neighborhood Hits	341	Shared Neighborhood Hits	23
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GIT2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.087300 (rank : 93)
Query Neighborhood Hits	174	Target Neighborhood Hits	381	Shared Neighborhood Hits	32
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.085943 (rank : 94)
Query Neighborhood Hits	174	Target Neighborhood Hits	323	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GRAP2_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.056385 (rank : 150)
Query Neighborhood Hits	174	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.053490 (rank : 169)
Query Neighborhood Hits	174	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.064515 (rank : 113)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.062408 (rank : 121)
Query Neighborhood Hits	174	Target Neighborhood Hits	309	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.064083 (rank : 116)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.064012 (rank : 117)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.081522 (rank : 99)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.056965 (rank : 146)
Query Neighborhood Hits	174	Target Neighborhood Hits	358	Shared Neighborhood Hits	18
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.055225 (rank : 157)
Query Neighborhood Hits	174	Target Neighborhood Hits	329	Shared Neighborhood Hits	22
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HRBL_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.059430 (rank : 129)
Query Neighborhood Hits	174	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.057824 (rank : 142)
Query Neighborhood Hits	174	Target Neighborhood Hits	269	Shared Neighborhood Hits	14
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

ITSN1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.061586 (rank : 123)
Query Neighborhood Hits	174	Target Neighborhood Hits	1757	Shared Neighborhood Hits	82
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.060690 (rank : 126)
Query Neighborhood Hits	174	Target Neighborhood Hits	1669	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.058532 (rank : 135)
Query Neighborhood Hits	174	Target Neighborhood Hits	1173	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.059228 (rank : 130)
Query Neighborhood Hits	174	Target Neighborhood Hits	1371	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MY18A_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.055652 (rank : 153)
Query Neighborhood Hits	174	Target Neighborhood Hits	1929	Shared Neighborhood Hits	86
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH10_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.050099 (rank : 194)
Query Neighborhood Hits	174	Target Neighborhood Hits	1612	Shared Neighborhood Hits	73
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.054149 (rank : 165)
Query Neighborhood Hits	174	Target Neighborhood Hits	1478	Shared Neighborhood Hits	77
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.054639 (rank : 161)
Query Neighborhood Hits	174	Target Neighborhood Hits	1461	Shared Neighborhood Hits	80
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.052933 (rank : 173)
Query Neighborhood Hits	174	Target Neighborhood Hits	1491	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH3_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.057011 (rank : 145)
Query Neighborhood Hits	174	Target Neighborhood Hits	1660	Shared Neighborhood Hits	83
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH4_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.055430 (rank : 156)
Query Neighborhood Hits	174	Target Neighborhood Hits	1377	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.052894 (rank : 175)
Query Neighborhood Hits	174	Target Neighborhood Hits	1476	Shared Neighborhood Hits	78
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH8_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.057127 (rank : 144)
Query Neighborhood Hits	174	Target Neighborhood Hits	1610	Shared Neighborhood Hits	82
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.055622 (rank : 154)
Query Neighborhood Hits	174	Target Neighborhood Hits	1600	Shared Neighborhood Hits	80
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.051311 (rank : 184)
Query Neighborhood Hits	174	Target Neighborhood Hits	1762	Shared Neighborhood Hits	77
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.052488 (rank : 178)
Query Neighborhood Hits	174	Target Neighborhood Hits	1829	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYO10_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.070748 (rank : 103)
Query Neighborhood Hits	174	Target Neighborhood Hits	920	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYO15_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.052025 (rank : 182)
Query Neighborhood Hits	174	Target Neighborhood Hits	671	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO15_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.052790 (rank : 176)
Query Neighborhood Hits	174	Target Neighborhood Hits	467	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO1E_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.064514 (rank : 114)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.064725 (rank : 112)
Query Neighborhood Hits	174	Target Neighborhood Hits	275	Shared Neighborhood Hits	27
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.065343 (rank : 110)
Query Neighborhood Hits	174	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO5B_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.056497 (rank : 149)
Query Neighborhood Hits	174	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

MYO5C_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.056359 (rank : 151)
Query Neighborhood Hits	174	Target Neighborhood Hits	1206	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYO6_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.050369 (rank : 190)
Query Neighborhood Hits	174	Target Neighborhood Hits	727	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO7A_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.052270 (rank : 180)
Query Neighborhood Hits	174	Target Neighborhood Hits	209	Shared Neighborhood Hits	23
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO7A_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.052925 (rank : 174)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	23
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

NCF2_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.054467 (rank : 162)
Query Neighborhood Hits	174	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.057806 (rank : 143)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	12
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.062981 (rank : 118)
Query Neighborhood Hits	174	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.054156 (rank : 164)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	19
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.064776 (rank : 111)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NUPL_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.066449 (rank : 107)
Query Neighborhood Hits	174	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.065805 (rank : 109)
Query Neighborhood Hits	174	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

P55G_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.055530 (rank : 155)
Query Neighborhood Hits	174	Target Neighborhood Hits	451	Shared Neighborhood Hits	37
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.052401 (rank : 179)
Query Neighborhood Hits	174	Target Neighborhood Hits	401	Shared Neighborhood Hits	31
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.104055 (rank : 86)
Query Neighborhood Hits	174	Target Neighborhood Hits	543	Shared Neighborhood Hits	54
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.072913 (rank : 100)
Query Neighborhood Hits	174	Target Neighborhood Hits	519	Shared Neighborhood Hits	54
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCTL_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.052136 (rank : 181)
Query Neighborhood Hits	174	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.052742 (rank : 177)
Query Neighborhood Hits	174	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PDZD8_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.058299 (rank : 137)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PKHA1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.072681 (rank : 101)
Query Neighborhood Hits	174	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.066717 (rank : 106)
Query Neighborhood Hits	174	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.051232 (rank : 185)
Query Neighborhood Hits	174	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA6_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.056537 (rank : 148)
Query Neighborhood Hits	174	Target Neighborhood Hits	556	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.057911 (rank : 141)
Query Neighborhood Hits	174	Target Neighborhood Hits	591	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SH3K1_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.058624 (rank : 134)
Query Neighborhood Hits	174	Target Neighborhood Hits	341	Shared Neighborhood Hits	26
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.064135 (rank : 115)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SMAP1_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.120378 (rank : 79)
Query Neighborhood Hits	174	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.121716 (rank : 77)
Query Neighborhood Hits	174	Target Neighborhood Hits	120	Shared Neighborhood Hits	13
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.122317 (rank : 75)
Query Neighborhood Hits	174	Target Neighborhood Hits	74	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.121874 (rank : 76)
Query Neighborhood Hits	174	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SRBS1_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.061589 (rank : 122)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.058253 (rank : 139)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	28
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC3_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.058835 (rank : 131)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.060761 (rank : 125)
Query Neighborhood Hits	174	Target Neighborhood Hits	232	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.053488 (rank : 170)
Query Neighborhood Hits	174	Target Neighborhood Hits	268	Shared Neighborhood Hits	18
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV3_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.054943 (rank : 159)
Query Neighborhood Hits	174	Target Neighborhood Hits	398	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.053858 (rank : 168)
Query Neighborhood Hits	174	Target Neighborhood Hits	404	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VINEX_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.060605 (rank : 127)
Query Neighborhood Hits	174	Target Neighborhood Hits	270	Shared Neighborhood Hits	20
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.065863 (rank : 108)
Query Neighborhood Hits	174	Target Neighborhood Hits	286	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

OPHN1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	174	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_HUMAN
NC score	0.992647 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	119
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG26_HUMAN
NC score	0.907613 (rank : 3)	θ value	1.90485e-175 (rank : 3)
Query Neighborhood Hits	174	Target Neighborhood Hits	281	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG09_HUMAN
NC score	0.806950 (rank : 4)	θ value	3.75424e-22 (rank : 11)
Query Neighborhood Hits	174	Target Neighborhood Hits	186	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
NC score	0.779594 (rank : 5)	θ value	2.77775e-25 (rank : 8)
Query Neighborhood Hits	174	Target Neighborhood Hits	190	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.778379 (rank : 6)	θ value	6.18819e-25 (rank : 9)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GMIP_MOUSE
NC score	0.772354 (rank : 7)	θ value	1.2077e-20 (rank : 12)
Query Neighborhood Hits	174	Target Neighborhood Hits	202	Shared Neighborhood Hits	68
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RGAP1_HUMAN
NC score	0.770196 (rank : 8)	θ value	5.60996e-18 (rank : 20)
Query Neighborhood Hits	174	Target Neighborhood Hits	189	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
NC score	0.767090 (rank : 9)	θ value	3.63628e-17 (rank : 21)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GMIP_HUMAN
NC score	0.764328 (rank : 10)	θ value	1.92812e-18 (rank : 19)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	66
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GRLF1_HUMAN
NC score	0.764068 (rank : 11)	θ value	2.59989e-23 (rank : 10)
Query Neighborhood Hits	174	Target Neighborhood Hits	167	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

CHIO_MOUSE
NC score	0.759918 (rank : 12)	θ value	1.57365e-28 (rank : 4)
Query Neighborhood Hits	174	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

3BP1_MOUSE
NC score	0.736106 (rank : 13)	θ value	7.84624e-12 (rank : 40)
Query Neighborhood Hits	174	Target Neighborhood Hits	238	Shared Neighborhood Hits	66
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG05_MOUSE
NC score	0.729187 (rank : 14)	θ value	2.97466e-19 (rank : 15)
Query Neighborhood Hits	174	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

CHIO_HUMAN
NC score	0.728915 (rank : 15)	θ value	3.50572e-28 (rank : 5)
Query Neighborhood Hits	174	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
NC score	0.727822 (rank : 16)	θ value	2.96777e-27 (rank : 6)
Query Neighborhood Hits	174	Target Neighborhood Hits	229	Shared Neighborhood Hits	63
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.726686 (rank : 17)	θ value	5.06226e-27 (rank : 7)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG05_HUMAN
NC score	0.725524 (rank : 18)	θ value	1.74391e-19 (rank : 13)
Query Neighborhood Hits	174	Target Neighborhood Hits	158	Shared Neighborhood Hits	69
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

TCGAP_MOUSE
NC score	0.724562 (rank : 19)	θ value	5.07402e-19 (rank : 17)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	66
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

3BP1_HUMAN
NC score	0.724331 (rank : 20)	θ value	3.76295e-14 (rank : 33)
Query Neighborhood Hits	174	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG01_HUMAN
NC score	0.719106 (rank : 21)	θ value	1.38178e-16 (rank : 25)
Query Neighborhood Hits	174	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG06_HUMAN
NC score	0.718867 (rank : 22)	θ value	8.67504e-11 (rank : 49)
Query Neighborhood Hits	174	Target Neighborhood Hits	114	Shared Neighborhood Hits	63
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.716966 (rank : 23)	θ value	2.52405e-10 (rank : 51)
Query Neighborhood Hits	174	Target Neighborhood Hits	105	Shared Neighborhood Hits	62
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG18_HUMAN
NC score	0.709029 (rank : 24)	θ value	1.133e-10 (rank : 50)
Query Neighborhood Hits	174	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG18_MOUSE
NC score	0.697045 (rank : 25)	θ value	2.13673e-09 (rank : 57)
Query Neighborhood Hits	174	Target Neighborhood Hits	110	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG08_MOUSE
NC score	0.696699 (rank : 26)	θ value	1.74796e-11 (rank : 43)
Query Neighborhood Hits	174	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_HUMAN
NC score	0.692989 (rank : 27)	θ value	2.28291e-11 (rank : 45)
Query Neighborhood Hits	174	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

ABR_HUMAN
NC score	0.678798 (rank : 28)	θ value	1.52774e-15 (rank : 29)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RBP1_MOUSE
NC score	0.676053 (rank : 29)	θ value	1.2105e-12 (rank : 37)
Query Neighborhood Hits	174	Target Neighborhood Hits	493	Shared Neighborhood Hits	95
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG04_HUMAN
NC score	0.675805 (rank : 30)	θ value	2.60593e-15 (rank : 30)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP2_HUMAN
NC score	0.667656 (rank : 31)	θ value	8.10077e-17 (rank : 23)
Query Neighborhood Hits	174	Target Neighborhood Hits	331	Shared Neighborhood Hits	72
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

BCR_HUMAN
NC score	0.667640 (rank : 32)	θ value	7.58209e-15 (rank : 31)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RHG25_MOUSE
NC score	0.667106 (rank : 33)	θ value	6.00763e-12 (rank : 39)
Query Neighborhood Hits	174	Target Neighborhood Hits	492	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RBP1_HUMAN
NC score	0.660960 (rank : 34)	θ value	3.52202e-12 (rank : 38)
Query Neighborhood Hits	174	Target Neighborhood Hits	521	Shared Neighborhood Hits	101
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

SRGP2_MOUSE
NC score	0.660795 (rank : 35)	θ value	1.80466e-16 (rank : 26)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	74
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
NC score	0.659870 (rank : 36)	θ value	3.63628e-17 (rank : 22)
Query Neighborhood Hits	174	Target Neighborhood Hits	390	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.657477 (rank : 37)	θ value	1.13037e-18 (rank : 18)
Query Neighborhood Hits	174	Target Neighborhood Hits	432	Shared Neighborhood Hits	88
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG25_HUMAN
NC score	0.652195 (rank : 38)	θ value	5.08577e-11 (rank : 48)
Query Neighborhood Hits	174	Target Neighborhood Hits	550	Shared Neighborhood Hits	97
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CEND2_HUMAN
NC score	0.645277 (rank : 39)	θ value	5.43371e-13 (rank : 36)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

TCGAP_HUMAN
NC score	0.644684 (rank : 40)	θ value	3.88503e-19 (rank : 16)
Query Neighborhood Hits	174	Target Neighborhood Hits	872	Shared Neighborhood Hits	70
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG07_MOUSE
NC score	0.622149 (rank : 41)	θ value	1.74796e-11 (rank : 42)
Query Neighborhood Hits	174	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.617663 (rank : 42)	θ value	3.89403e-11 (rank : 47)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

TAGAP_HUMAN
NC score	0.615804 (rank : 43)	θ value	8.40245e-06 (rank : 65)
Query Neighborhood Hits	174	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.613719 (rank : 44)	θ value	0.000121331 (rank : 70)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CEND3_MOUSE
NC score	0.600676 (rank : 45)	θ value	2.28291e-11 (rank : 44)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.592279 (rank : 46)	θ value	3.89403e-11 (rank : 46)
Query Neighborhood Hits	174	Target Neighborhood Hits	275	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CE005_HUMAN
NC score	0.590190 (rank : 47)	θ value	7.34386e-10 (rank : 54)
Query Neighborhood Hits	174	Target Neighborhood Hits	213	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.588871 (rank : 48)	θ value	7.34386e-10 (rank : 55)
Query Neighborhood Hits	174	Target Neighborhood Hits	238	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

STA13_HUMAN
NC score	0.575899 (rank : 49)	θ value	1.06045e-08 (rank : 58)
Query Neighborhood Hits	174	Target Neighborhood Hits	89	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STAR8_MOUSE
NC score	0.573282 (rank : 50)	θ value	5.81887e-07 (rank : 61)
Query Neighborhood Hits	174	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
NC score	0.568100 (rank : 51)	θ value	2.61198e-07 (rank : 60)
Query Neighborhood Hits	174	Target Neighborhood Hits	216	Shared Neighborhood Hits	61
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_MOUSE
NC score	0.564423 (rank : 52)	θ value	6.87365e-08 (rank : 59)
Query Neighborhood Hits	174	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CEND1_MOUSE
NC score	0.557506 (rank : 53)	θ value	5.62301e-10 (rank : 53)
Query Neighborhood Hits	174	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.536703 (rank : 54)	θ value	2.13673e-09 (rank : 56)
Query Neighborhood Hits	174	Target Neighborhood Hits	284	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

K1688_MOUSE
NC score	0.497552 (rank : 55)	θ value	2.44474e-05 (rank : 66)
Query Neighborhood Hits	174	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.483880 (rank : 56)	θ value	5.44631e-05 (rank : 69)
Query Neighborhood Hits	174	Target Neighborhood Hits	217	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

MYO9B_MOUSE
NC score	0.410653 (rank : 57)	θ value	2.35696e-16 (rank : 27)
Query Neighborhood Hits	174	Target Neighborhood Hits	311	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.404975 (rank : 58)	θ value	1.38178e-16 (rank : 24)
Query Neighborhood Hits	174	Target Neighborhood Hits	641	Shared Neighborhood Hits	82
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

DP13A_HUMAN
NC score	0.370453 (rank : 59)	θ value	2.20605e-14 (rank : 32)
Query Neighborhood Hits	174	Target Neighborhood Hits	107	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
NC score	0.367222 (rank : 60)	θ value	1.42992e-13 (rank : 35)
Query Neighborhood Hits	174	Target Neighborhood Hits	96	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

P85A_HUMAN
NC score	0.364619 (rank : 61)	θ value	6.43352e-06 (rank : 63)
Query Neighborhood Hits	174	Target Neighborhood Hits	479	Shared Neighborhood Hits	87
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.357746 (rank : 62)	θ value	2.44474e-05 (rank : 67)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	82
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DP13B_MOUSE
NC score	0.347783 (rank : 63)	θ value	7.84624e-12 (rank : 41)
Query Neighborhood Hits	174	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_HUMAN
NC score	0.337092 (rank : 64)	θ value	4.30538e-10 (rank : 52)
Query Neighborhood Hits	174	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CENB2_HUMAN
NC score	0.288718 (rank : 65)	θ value	1.16975e-15 (rank : 28)
Query Neighborhood Hits	174	Target Neighborhood Hits	425	Shared Neighborhood Hits	32
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
NC score	0.286031 (rank : 66)	θ value	2.27762e-19 (rank : 14)
Query Neighborhood Hits	174	Target Neighborhood Hits	395	Shared Neighborhood Hits	28
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

OCRL_HUMAN
NC score	0.283732 (rank : 67)	θ value	0.0252991 (rank : 74)
Query Neighborhood Hits	174	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
NC score	0.276923 (rank : 68)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	174	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

CENB1_HUMAN
NC score	0.270557 (rank : 69)	θ value	6.41864e-14 (rank : 34)
Query Neighborhood Hits	174	Target Neighborhood Hits	383	Shared Neighborhood Hits	26
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DDEF2_HUMAN
NC score	0.215995 (rank : 70)	θ value	2.88788e-06 (rank : 62)
Query Neighborhood Hits	174	Target Neighborhood Hits	599	Shared Neighborhood Hits	34
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.212972 (rank : 71)	θ value	8.40245e-06 (rank : 64)
Query Neighborhood Hits	174	Target Neighborhood Hits	625	Shared Neighborhood Hits	35
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF1_MOUSE
NC score	0.203230 (rank : 72)	θ value	5.44631e-05 (rank : 68)
Query Neighborhood Hits	174	Target Neighborhood Hits	592	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDFL1_HUMAN
NC score	0.191845 (rank : 73)	θ value	0.000461057 (rank : 71)
Query Neighborhood Hits	174	Target Neighborhood Hits	353	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
NC score	0.171321 (rank : 74)	θ value	0.0193708 (rank : 73)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	20
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

SMP1L_HUMAN
NC score	0.122317 (rank : 75)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	174	Target Neighborhood Hits	74	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
NC score	0.121874 (rank : 76)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	174	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMAP1_MOUSE
NC score	0.121716 (rank : 77)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	174	Target Neighborhood Hits	120	Shared Neighborhood Hits	13
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CENA1_HUMAN
NC score	0.120436 (rank : 78)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	174	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SMAP1_HUMAN
NC score	0.120378 (rank : 79)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	174	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CENA2_HUMAN
NC score	0.117982 (rank : 80)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ARFG1_MOUSE
NC score	0.116540 (rank : 81)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	174	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENA2_MOUSE
NC score	0.113636 (rank : 82)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	174	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

ARFG3_HUMAN
NC score	0.112969 (rank : 83)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	174	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
NC score	0.112508 (rank : 84)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	174	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG1_HUMAN
NC score	0.111631 (rank : 85)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	174	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

P85B_HUMAN
NC score	0.104055 (rank : 86)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	174	Target Neighborhood Hits	543	Shared Neighborhood Hits	54
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CENG1_MOUSE
NC score	0.103583 (rank : 87)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	174	Target Neighborhood Hits	531	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
NC score	0.101262 (rank : 88)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	174	Target Neighborhood Hits	544	Shared Neighborhood Hits	20
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG3_MOUSE
NC score	0.094986 (rank : 89)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	174	Target Neighborhood Hits	467	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.093776 (rank : 90)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	174	Target Neighborhood Hits	455	Shared Neighborhood Hits	15
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG2_MOUSE
NC score	0.088020 (rank : 91)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	174	Target Neighborhood Hits	463	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
NC score	0.087809 (rank : 92)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	174	Target Neighborhood Hits	471	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT2_HUMAN
NC score	0.087300 (rank : 93)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	174	Target Neighborhood Hits	381	Shared Neighborhood Hits	32
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
NC score	0.085943 (rank : 94)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	174	Target Neighborhood Hits	323	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GIT1_HUMAN
NC score	0.084970 (rank : 95)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	174	Target Neighborhood Hits	336	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

RPB5_HUMAN
NC score	0.084116 (rank : 96)	θ value	0.0961366 (rank : 82)
Query Neighborhood Hits	174	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P19388, O43380, Q6PIH5, Q9BT06	Gene names	POLR2E
Domain Architecture
Description	DNA-directed RNA polymerase II 23 kDa polypeptide (EC 2.7.7.6) (RPB25) (RPB5) (RPABC1) (XAP4).

RPB5_MOUSE
NC score	0.083607 (rank : 97)	θ value	0.0961366 (rank : 83)
Query Neighborhood Hits	174	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q80UW8	Gene names	Polr2e
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase II 23 kDa polypeptide (EC 2.7.7.6) (RPB25) (RPB5) (RPABC1).

GIT1_MOUSE
NC score	0.083128 (rank : 98)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	174	Target Neighborhood Hits	341	Shared Neighborhood Hits	23
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GRP3_HUMAN
NC score	0.081522 (rank : 99)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

P85B_MOUSE
NC score	0.072913 (rank : 100)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	174	Target Neighborhood Hits	519	Shared Neighborhood Hits	54
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PKHA1_HUMAN
NC score	0.072681 (rank : 101)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	174	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

DAPP1_MOUSE
NC score	0.071510 (rank : 102)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

MYO10_HUMAN
NC score	0.070748 (rank : 103)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	174	Target Neighborhood Hits	920	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CIP4_HUMAN
NC score	0.070630 (rank : 104)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	174	Target Neighborhood Hits	374	Shared Neighborhood Hits	41
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

DAPP1_HUMAN
NC score	0.067404 (rank : 105)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA1_MOUSE
NC score	0.066717 (rank : 106)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	174	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

NUPL_HUMAN
NC score	0.066449 (rank : 107)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	174	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

VINEX_MOUSE
NC score	0.065863 (rank : 108)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	174	Target Neighborhood Hits	286	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NUPL_MOUSE
NC score	0.065805 (rank : 109)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	174	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

MYO1F_MOUSE
NC score	0.065343 (rank : 110)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	174	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCK2_HUMAN
NC score	0.064776 (rank : 111)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

MYO1F_HUMAN
NC score	0.064725 (rank : 112)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	174	Target Neighborhood Hits	275	Shared Neighborhood Hits	27
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

GRAP_HUMAN
NC score	0.064515 (rank : 113)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

MYO1E_HUMAN
NC score	0.064514 (rank : 114)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SH3K1_MOUSE
NC score	0.064135 (rank : 115)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

GRB2_HUMAN
NC score	0.064083 (rank : 116)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.064012 (rank : 117)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF4_MOUSE
NC score	0.062981 (rank : 118)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	174	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CT2NL_HUMAN
NC score	0.062897 (rank : 119)	θ value	0.00228821 (rank : 72)
Query Neighborhood Hits	174	Target Neighborhood Hits	1059	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CD2AP_HUMAN
NC score	0.062765 (rank : 120)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	174	Target Neighborhood Hits	315	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

GRAP_MOUSE
NC score	0.062408 (rank : 121)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	174	Target Neighborhood Hits	309	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SRBS1_HUMAN
NC score	0.061589 (rank : 122)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ITSN1_HUMAN
NC score	0.061586 (rank : 123)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	174	Target Neighborhood Hits	1757	Shared Neighborhood Hits	82
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MYO5A_MOUSE
NC score	0.061109 (rank : 124)	θ value	0.0961366 (rank : 81)
Query Neighborhood Hits	174	Target Neighborhood Hits	1117	Shared Neighborhood Hits	61
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

STAC3_MOUSE
NC score	0.060761 (rank : 125)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	174	Target Neighborhood Hits	232	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ITSN1_MOUSE
NC score	0.060690 (rank : 126)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	174	Target Neighborhood Hits	1669	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VINEX_HUMAN
NC score	0.060605 (rank : 127)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	174	Target Neighborhood Hits	270	Shared Neighborhood Hits	20
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

MYO5A_HUMAN
NC score	0.059872 (rank : 128)	θ value	0.0563607 (rank : 77)
Query Neighborhood Hits	174	Target Neighborhood Hits	1092	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

HRBL_HUMAN
NC score	0.059430 (rank : 129)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	174	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

ITSN2_MOUSE
NC score	0.059228 (rank : 130)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	174	Target Neighborhood Hits	1371	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

STAC3_HUMAN
NC score	0.058835 (rank : 131)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ABI2_HUMAN
NC score	0.058708 (rank : 132)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	174	Target Neighborhood Hits	350	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.058690 (rank : 133)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	17
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SH3K1_HUMAN
NC score	0.058624 (rank : 134)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	174	Target Neighborhood Hits	341	Shared Neighborhood Hits	26
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ITSN2_HUMAN
NC score	0.058532 (rank : 135)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	174	Target Neighborhood Hits	1173	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SH3G2_MOUSE
NC score	0.058350 (rank : 136)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	174	Target Neighborhood Hits	319	Shared Neighborhood Hits	25
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PDZD8_HUMAN
NC score	0.058299 (rank : 137)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

FA13A_HUMAN
NC score	0.058292 (rank : 138)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	174	Target Neighborhood Hits	102	Shared Neighborhood Hits	12
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

SRBS1_MOUSE
NC score	0.058253 (rank : 139)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	28
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

FA13A_MOUSE
NC score	0.058055 (rank : 140)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

PKHA6_MOUSE
NC score	0.057911 (rank : 141)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	174	Target Neighborhood Hits	591	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

HRBL_MOUSE
NC score	0.057824 (rank : 142)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	174	Target Neighborhood Hits	269	Shared Neighborhood Hits	14
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

NCF4_HUMAN
NC score	0.057806 (rank : 143)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	12
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

MYH8_HUMAN
NC score	0.057127 (rank : 144)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	174	Target Neighborhood Hits	1610	Shared Neighborhood Hits	82
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH3_HUMAN
NC score	0.057011 (rank : 145)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	174	Target Neighborhood Hits	1660	Shared Neighborhood Hits	83
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

HCLS1_HUMAN
NC score	0.056965 (rank : 146)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	174	Target Neighborhood Hits	358	Shared Neighborhood Hits	18
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MY18A_MOUSE
NC score	0.056680 (rank : 147)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	174	Target Neighborhood Hits	1989	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PKHA6_HUMAN
NC score	0.056537 (rank : 148)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	174	Target Neighborhood Hits	556	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

MYO5B_HUMAN
NC score	0.056497 (rank : 149)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	174	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

GRAP2_HUMAN
NC score	0.056385 (rank : 150)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	174	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

MYO5C_HUMAN
NC score	0.056359 (rank : 151)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	174	Target Neighborhood Hits	1206	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

DGKH_HUMAN
NC score	0.055805 (rank : 152)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	174	Target Neighborhood Hits	255	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MY18A_HUMAN
NC score	0.055652 (rank : 153)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	174	Target Neighborhood Hits	1929	Shared Neighborhood Hits	86
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH8_MOUSE
NC score	0.055622 (rank : 154)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	174	Target Neighborhood Hits	1600	Shared Neighborhood Hits	80
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

P55G_HUMAN
NC score	0.055530 (rank : 155)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	174	Target Neighborhood Hits	451	Shared Neighborhood Hits	37
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

MYH4_HUMAN
NC score	0.055430 (rank : 156)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	174	Target Neighborhood Hits	1377	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

HCLS1_MOUSE
NC score	0.055225 (rank : 157)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	174	Target Neighborhood Hits	329	Shared Neighborhood Hits	22
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CD2AP_MOUSE
NC score	0.055004 (rank : 158)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	174	Target Neighborhood Hits	336	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

VAV3_HUMAN
NC score	0.054943 (rank : 159)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	174	Target Neighborhood Hits	398	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SH3G2_HUMAN
NC score	0.054871 (rank : 160)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

MYH1_MOUSE
NC score	0.054639 (rank : 161)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	174	Target Neighborhood Hits	1461	Shared Neighborhood Hits	80
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

NCF2_HUMAN
NC score	0.054467 (rank : 162)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	174	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

MYH6_MOUSE
NC score	0.054250 (rank : 163)	θ value	0.0563607 (rank : 76)
Query Neighborhood Hits	174	Target Neighborhood Hits	1501	Shared Neighborhood Hits	76
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

NCK1_HUMAN
NC score	0.054156 (rank : 164)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	19
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

MYH1_HUMAN
NC score	0.054149 (rank : 165)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	174	Target Neighborhood Hits	1478	Shared Neighborhood Hits	77
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH11_MOUSE
NC score	0.054019 (rank : 166)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	174	Target Neighborhood Hits	1777	Shared Neighborhood Hits	84
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

DNMBP_HUMAN
NC score	0.053929 (rank : 167)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	174	Target Neighborhood Hits	413	Shared Neighborhood Hits	30
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV3_MOUSE
NC score	0.053858 (rank : 168)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	174	Target Neighborhood Hits	404	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GRAP2_MOUSE
NC score	0.053490 (rank : 169)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	174	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAC_MOUSE
NC score	0.053488 (rank : 170)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	174	Target Neighborhood Hits	268	Shared Neighborhood Hits	18
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MYH11_HUMAN
NC score	0.053321 (rank : 171)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	174	Target Neighborhood Hits	1806	Shared Neighborhood Hits	84
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH6_HUMAN
NC score	0.053285 (rank : 172)	θ value	0.0736092 (rank : 80)
Query Neighborhood Hits	174	Target Neighborhood Hits	1426	Shared Neighborhood Hits	72
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH2_HUMAN
NC score	0.052933 (rank : 173)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	174	Target Neighborhood Hits	1491	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYO7A_MOUSE
NC score	0.052925 (rank : 174)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	23
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYH4_MOUSE
NC score	0.052894 (rank : 175)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	174	Target Neighborhood Hits	1476	Shared Neighborhood Hits	78
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYO15_MOUSE
NC score	0.052790 (rank : 176)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	174	Target Neighborhood Hits	467	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PCTL_MOUSE
NC score	0.052742 (rank : 177)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	174	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

MYH9_MOUSE
NC score	0.052488 (rank : 178)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	174	Target Neighborhood Hits	1829	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

P55G_MOUSE
NC score	0.052401 (rank : 179)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	174	Target Neighborhood Hits	401	Shared Neighborhood Hits	31
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

MYO7A_HUMAN
NC score	0.052270 (rank : 180)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	174	Target Neighborhood Hits	209	Shared Neighborhood Hits	23
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

PCTL_HUMAN
NC score	0.052136 (rank : 181)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	174	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

MYO15_HUMAN
NC score	0.052025 (rank : 182)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	174	Target Neighborhood Hits	671	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ABI1_MOUSE
NC score	0.051723 (rank : 183)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	174	Target Neighborhood Hits	246	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

MYH9_HUMAN
NC score	0.051311 (rank : 184)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	174	Target Neighborhood Hits	1762	Shared Neighborhood Hits	77
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PKHA2_MOUSE
NC score	0.051232 (rank : 185)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	174	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CRKL_HUMAN
NC score	0.051188 (rank : 186)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	174	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DNMBP_MOUSE
NC score	0.050975 (rank : 187)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	37
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MYH13_HUMAN
NC score	0.050741 (rank : 188)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	174	Target Neighborhood Hits	1504	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

RAD50_MOUSE
NC score	0.050692 (rank : 189)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	174	Target Neighborhood Hits	1366	Shared Neighborhood Hits	72
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

MYO6_HUMAN
NC score	0.050369 (rank : 190)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	174	Target Neighborhood Hits	727	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

ARHG7_MOUSE
NC score	0.050343 (rank : 191)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DGKD_HUMAN
NC score	0.050321 (rank : 192)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	174	Target Neighborhood Hits	231	Shared Neighborhood Hits	21
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

MYH14_MOUSE
NC score	0.050112 (rank : 193)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	174	Target Neighborhood Hits	1225	Shared Neighborhood Hits	61
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH10_MOUSE
NC score	0.050099 (rank : 194)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	174	Target Neighborhood Hits	1612	Shared Neighborhood Hits	73
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MIPO1_HUMAN
NC score	0.049961 (rank : 195)	θ value	0.279714 (rank : 85)
Query Neighborhood Hits	174	Target Neighborhood Hits	486	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

RAD50_HUMAN
NC score	0.049880 (rank : 196)	θ value	0.125558 (rank : 84)
Query Neighborhood Hits	174	Target Neighborhood Hits	1317	Shared Neighborhood Hits	68
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

CR034_MOUSE
NC score	0.048471 (rank : 197)	θ value	0.47712 (rank : 87)
Query Neighborhood Hits	174	Target Neighborhood Hits	643	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

BICD1_MOUSE
NC score	0.045667 (rank : 198)	θ value	0.47712 (rank : 86)
Query Neighborhood Hits	174	Target Neighborhood Hits	837	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CCD46_HUMAN
NC score	0.045068 (rank : 199)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	174	Target Neighborhood Hits	1430	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

PRP40_HUMAN
NC score	0.044555 (rank : 200)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	174	Target Neighborhood Hits	442	Shared Neighborhood Hits	30
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

SYCP1_HUMAN
NC score	0.044538 (rank : 201)	θ value	0.62314 (rank : 91)
Query Neighborhood Hits	174	Target Neighborhood Hits	1313	Shared Neighborhood Hits	68
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CENPF_HUMAN
NC score	0.044537 (rank : 202)	θ value	3.0926 (rank : 121)
Query Neighborhood Hits	174	Target Neighborhood Hits	1932	Shared Neighborhood Hits	87
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CE290_HUMAN
NC score	0.043675 (rank : 203)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	174	Target Neighborhood Hits	1553	Shared Neighborhood Hits	71
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

LRC45_HUMAN
NC score	0.043064 (rank : 204)	θ value	0.0431538 (rank : 75)
Query Neighborhood Hits	174	Target Neighborhood Hits	933	Shared Neighborhood Hits	50
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CCD46_MOUSE
NC score	0.042753 (rank : 205)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	174	Target Neighborhood Hits	1405	Shared Neighborhood Hits	75
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

NEBU_HUMAN
NC score	0.042525 (rank : 206)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	174	Target Neighborhood Hits	420	Shared Neighborhood Hits	30
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

BICD1_HUMAN
NC score	0.042153 (rank : 207)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	174	Target Neighborhood Hits	844	Shared Neighborhood Hits	61
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

PRP40_MOUSE
NC score	0.040830 (rank : 208)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	174	Target Neighborhood Hits	447	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

CT096_HUMAN
NC score	0.040787 (rank : 209)	θ value	0.813845 (rank : 95)
Query Neighborhood Hits	174	Target Neighborhood Hits	438	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

CP135_HUMAN
NC score	0.040632 (rank : 210)	θ value	0.62314 (rank : 89)
Query Neighborhood Hits	174	Target Neighborhood Hits	1290	Shared Neighborhood Hits	68
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

LUZP1_HUMAN
NC score	0.040239 (rank : 211)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	174	Target Neighborhood Hits	739	Shared Neighborhood Hits	51
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

TPR_HUMAN
NC score	0.040233 (rank : 212)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	174	Target Neighborhood Hits	1921	Shared Neighborhood Hits	74
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CP250_HUMAN
NC score	0.039067 (rank : 213)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	174	Target Neighborhood Hits	1805	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CK5P2_HUMAN
NC score	0.038599 (rank : 214)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	174	Target Neighborhood Hits	1433	Shared Neighborhood Hits	73
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CYTSA_MOUSE
NC score	0.038464 (rank : 215)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	174	Target Neighborhood Hits	1104	Shared Neighborhood Hits	64
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

CYTSA_HUMAN
NC score	0.037640 (rank : 216)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	174	Target Neighborhood Hits	1138	Shared Neighborhood Hits	62
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

REST_MOUSE
NC score	0.036039 (rank : 217)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	174	Target Neighborhood Hits	1506	Shared Neighborhood Hits	75
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

CP135_MOUSE
NC score	0.035911 (rank : 218)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	174	Target Neighborhood Hits	1278	Shared Neighborhood Hits	68
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CCHCR_MOUSE
NC score	0.035867 (rank : 219)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	174	Target Neighborhood Hits	932	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

TXLNB_HUMAN
NC score	0.035726 (rank : 220)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	174	Target Neighborhood Hits	912	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

CT2NL_MOUSE
NC score	0.035610 (rank : 221)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	174	Target Neighborhood Hits	902	Shared Neighborhood Hits	56
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CCD39_HUMAN
NC score	0.035092 (rank : 222)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	174	Target Neighborhood Hits	868	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

RBCC1_MOUSE
NC score	0.033639 (rank : 223)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	174	Target Neighborhood Hits	1048	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RUFY2_MOUSE
NC score	0.032601 (rank : 224)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	174	Target Neighborhood Hits	820	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SYNE1_HUMAN
NC score	0.031024 (rank : 225)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	174	Target Neighborhood Hits	1484	Shared Neighborhood Hits	73
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

RUFY2_HUMAN
NC score	0.030585 (rank : 226)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	174	Target Neighborhood Hits	1208	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

EP400_MOUSE
NC score	0.030521 (rank : 227)	θ value	0.0736092 (rank : 79)
Query Neighborhood Hits	174	Target Neighborhood Hits	592	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

COG7_HUMAN
NC score	0.030432 (rank : 228)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	P83436, Q6UWU7	Gene names	COG7
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 7.

SMC3_MOUSE
NC score	0.029662 (rank : 229)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	174	Target Neighborhood Hits	1187	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.029190 (rank : 230)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	174	Target Neighborhood Hits	1186	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

TNNT3_HUMAN
NC score	0.028936 (rank : 231)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	174	Target Neighborhood Hits	327	Shared Neighborhood Hits	41
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

ANR11_HUMAN
NC score	0.028896 (rank : 232)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	174	Target Neighborhood Hits	1289	Shared Neighborhood Hits	63
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

A20A2_HUMAN
NC score	0.027672 (rank : 233)	θ value	2.36792 (rank : 110)
Query Neighborhood Hits	174	Target Neighborhood Hits	716	Shared Neighborhood Hits	51
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

TNNT3_MOUSE
NC score	0.027433 (rank : 234)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	174	Target Neighborhood Hits	317	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZ47, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46	Gene names	Tnnt3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT).

TNNT1_MOUSE
NC score	0.027153 (rank : 235)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	174	Target Neighborhood Hits	212	Shared Neighborhood Hits	31
SwissProt Accessions	O88346, O88795, Q9QUP7	Gene names	Tnnt1
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

MMRN1_HUMAN
NC score	0.026969 (rank : 236)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	174	Target Neighborhood Hits	636	Shared Neighborhood Hits	44
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

KIF4A_HUMAN
NC score	0.025953 (rank : 237)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	174	Target Neighborhood Hits	1159	Shared Neighborhood Hits	64
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

ANGP2_HUMAN
NC score	0.025853 (rank : 238)	θ value	0.0736092 (rank : 78)
Query Neighborhood Hits	174	Target Neighborhood Hits	400	Shared Neighborhood Hits	41
SwissProt Accessions	O15123, Q9NRR7, Q9P2Y7	Gene names	ANGPT2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

JIP2_HUMAN
NC score	0.025444 (rank : 239)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	174	Target Neighborhood Hits	288	Shared Neighborhood Hits	15
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

VATH_MOUSE
NC score	0.024177 (rank : 240)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	174	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BVE3, Q921X8	Gene names	Atp6v1h
Domain Architecture	No domain graphic available
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H).

VATH_HUMAN
NC score	0.024146 (rank : 241)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	174	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UI12, Q6PK44, Q9H3E3, Q9Y300	Gene names	ATP6V1H
Domain Architecture
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit SFD) (VMA13) (Nef-binding protein 1) (NBP1).

PICK1_MOUSE
NC score	0.023692 (rank : 242)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

RADI_MOUSE
NC score	0.023448 (rank : 243)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	174	Target Neighborhood Hits	773	Shared Neighborhood Hits	51
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

MCPH1_MOUSE
NC score	0.022146 (rank : 244)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	174	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

TNNT1_HUMAN
NC score	0.021314 (rank : 245)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	174	Target Neighborhood Hits	211	Shared Neighborhood Hits	26
SwissProt Accessions	P13805, O95472, Q16061	Gene names	TNNT1, TNT
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

TRI37_HUMAN
NC score	0.021137 (rank : 246)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
NC score	0.021086 (rank : 247)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	174	Target Neighborhood Hits	316	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

FA47B_HUMAN
NC score	0.020963 (rank : 248)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	174	Target Neighborhood Hits	431	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MACF1_HUMAN
NC score	0.020799 (rank : 249)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	174	Target Neighborhood Hits	1341	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

ARHG8_MOUSE
NC score	0.020365 (rank : 250)	θ value	3.0926 (rank : 120)
Query Neighborhood Hits	174	Target Neighborhood Hits	79	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

PSL1_HUMAN
NC score	0.019512 (rank : 251)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	174	Target Neighborhood Hits	650	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

GP153_HUMAN
NC score	0.018363 (rank : 252)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

HN1L_HUMAN
NC score	0.016826 (rank : 253)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	174	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

CK036_HUMAN
NC score	0.014884 (rank : 254)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	174	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q2M3A8, Q6TF48, Q8N7R8, Q8N9X7	Gene names	C11orf36
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf36.

FER_HUMAN
NC score	0.014391 (rank : 255)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	174	Target Neighborhood Hits	1278	Shared Neighborhood Hits	51
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

EXOC3_MOUSE
NC score	0.013788 (rank : 256)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q6KAR6	Gene names	Exoc3, Sec6l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 3 (Exocyst complex component Sec6).

TTC28_HUMAN
NC score	0.013621 (rank : 257)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	174	Target Neighborhood Hits	271	Shared Neighborhood Hits	7
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_MOUSE
NC score	0.013534 (rank : 258)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	174	Target Neighborhood Hits	194	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TPX2_HUMAN
NC score	0.012925 (rank : 259)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	174	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULW0, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1	Gene names	TPX2, C20orf1, C20orf2, DIL2, HCA519
Domain Architecture	No domain graphic available
Description	Targeting protein for Xklp2 (Restricted expression proliferation- associated protein 100) (p100) (Differentially expressed in cancerous and noncancerous lung cells 2) (DIL-2) (Protein FLS353) (Hepatocellular carcinoma-associated antigen 519).

GEMI5_MOUSE
NC score	0.012160 (rank : 260)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	174	Target Neighborhood Hits	424	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

T22D4_HUMAN
NC score	0.012009 (rank : 261)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	174	Target Neighborhood Hits	403	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

CKAP2_HUMAN
NC score	0.011195 (rank : 262)	θ value	5.27518 (rank : 139)
Query Neighborhood Hits	174	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWK9, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4	Gene names	CKAP2, LB1, TMAP
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2 (Tumor-associated microtubule- associated protein) (CTCL tumor antigen se20-10).

K6PF_HUMAN
NC score	0.011044 (rank : 263)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	174	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P08237, Q16814, Q16815	Gene names	PFKM
Domain Architecture
Description	6-phosphofructokinase, muscle type (EC 2.7.1.11) (Phosphofructokinase 1) (Phosphohexokinase) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphofructokinase-M).

SNIP_HUMAN
NC score	0.010730 (rank : 264)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	174	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

WWP1_HUMAN
NC score	0.010665 (rank : 265)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	174	Target Neighborhood Hits	262	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

VATD_MOUSE
NC score	0.010222 (rank : 266)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	174	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P57746	Gene names	Atp6v1d, Atp6m, Vatd
Domain Architecture
Description	Vacuolar ATP synthase subunit D (EC 3.6.3.14) (V-ATPase D subunit) (Vacuolar proton pump D subunit) (V-ATPase 28 kDa accessory protein).

K6PL_HUMAN
NC score	0.009996 (rank : 267)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	174	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P17858, Q96A64, Q96IH4, Q9BR91	Gene names	PFKL
Domain Architecture
Description	6-phosphofructokinase, liver type (EC 2.7.1.11) (Phosphofructokinase 1) (Phosphohexokinase) (Phosphofructo-1-kinase isozyme B) (PFK-B).

AFF1_MOUSE
NC score	0.009260 (rank : 268)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	174	Target Neighborhood Hits	351	Shared Neighborhood Hits	11
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

DIAP3_MOUSE
NC score	0.008876 (rank : 269)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	174	Target Neighborhood Hits	221	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z207	Gene names	Diaph3, Diap3
Domain Architecture
Description	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2).

CAYP2_MOUSE
NC score	0.007429 (rank : 270)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	174	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BUG5, Q8C1J6	Gene names	Caps2
Domain Architecture	No domain graphic available
Description	Calcyphosin-2 (Calcyphosine-2).

K0776_HUMAN
NC score	0.007083 (rank : 271)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	174	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	O94874, Q8N765, Q9NTQ0	Gene names	KIAA0776
Domain Architecture	No domain graphic available
Description	Protein KIAA0776.

ARP8_MOUSE
NC score	0.007002 (rank : 272)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	174	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R2S9, Q9CYC4	Gene names	Actr8
Domain Architecture
Description	Actin-related protein 8.

HS74L_MOUSE
NC score	0.006495 (rank : 273)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	174	Target Neighborhood Hits	141	Shared Neighborhood Hits	10
SwissProt Accessions	P48722, P97854, Q8BQD0, Q8CC45, Q91X29	Gene names	Hspa4l, Apg1, Hsp4l, Osp94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

HS74L_HUMAN
NC score	0.005535 (rank : 274)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	174	Target Neighborhood Hits	141	Shared Neighborhood Hits	13
SwissProt Accessions	O95757, Q4W5M5, Q8IWA2	Gene names	HSPA4L, APG1, OSP94
Domain Architecture
Description	Heat shock 70 kDa protein 4L (Osmotic stress protein 94) (Heat shock 70-related protein APG-1).

ARHGC_HUMAN
NC score	0.005396 (rank : 275)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	174	Target Neighborhood Hits	351	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MAST4_HUMAN
NC score	-0.000200 (rank : 276)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	174	Target Neighborhood Hits	1804	Shared Neighborhood Hits	32
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

BOC_HUMAN
NC score	-0.002618 (rank : 277)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	174	Target Neighborhood Hits	543	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

M3K13_HUMAN
NC score	-0.003880 (rank : 278)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	174	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

ZN467_MOUSE
NC score	-0.006956 (rank : 279)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	174	Target Neighborhood Hits	794	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZL0, Q9JJ98	Gene names	Znf467, Ezi, Zfp467
Domain Architecture	No domain graphic available
Description	Zinc finger protein 467 (Endothelial cell-derived zinc finger protein) (EZI).