Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : CEND3_MOUSE

For an explanation of this page, click here

CEND3_MOUSE
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CEND1_HUMAN
θ value	0 (rank : 1)	NC score	0.939446 (rank : 5)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	0 (rank : 2)	NC score	0.945697 (rank : 4)
Query Neighborhood Hits	228	Target Neighborhood Hits	260	Shared Neighborhood Hits	139
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	0 (rank : 3)	NC score	0.951394 (rank : 3)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	111
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	0 (rank : 4)	NC score	0.988977 (rank : 2)
Query Neighborhood Hits	228	Target Neighborhood Hits	275	Shared Neighborhood Hits	184
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	228
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CENG3_HUMAN
θ value	1.92812e-18 (rank : 6)	NC score	0.467062 (rank : 74)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	4.29542e-18 (rank : 7)	NC score	0.467325 (rank : 73)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DDFL1_HUMAN
θ value	2.7842e-17 (rank : 8)	NC score	0.508239 (rank : 51)
Query Neighborhood Hits	228	Target Neighborhood Hits	353	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

MYO9B_HUMAN
θ value	2.7842e-17 (rank : 9)	NC score	0.326012 (rank : 88)
Query Neighborhood Hits	228	Target Neighborhood Hits	641	Shared Neighborhood Hits	78
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	2.7842e-17 (rank : 10)	NC score	0.328412 (rank : 87)
Query Neighborhood Hits	228	Target Neighborhood Hits	311	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

DDFL1_MOUSE
θ value	1.38178e-16 (rank : 11)	NC score	0.485639 (rank : 61)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	58
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENG2_HUMAN
θ value	1.80466e-16 (rank : 12)	NC score	0.444266 (rank : 77)
Query Neighborhood Hits	228	Target Neighborhood Hits	471	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	3.07829e-16 (rank : 13)	NC score	0.446498 (rank : 76)
Query Neighborhood Hits	228	Target Neighborhood Hits	463	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

GRLF1_HUMAN
θ value	4.02038e-16 (rank : 14)	NC score	0.595937 (rank : 12)
Query Neighborhood Hits	228	Target Neighborhood Hits	167	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

CENB2_HUMAN
θ value	5.25075e-16 (rank : 15)	NC score	0.475939 (rank : 70)
Query Neighborhood Hits	228	Target Neighborhood Hits	425	Shared Neighborhood Hits	75
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG1_HUMAN
θ value	5.25075e-16 (rank : 16)	NC score	0.477039 (rank : 67)
Query Neighborhood Hits	228	Target Neighborhood Hits	544	Shared Neighborhood Hits	63
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	5.25075e-16 (rank : 17)	NC score	0.482021 (rank : 63)
Query Neighborhood Hits	228	Target Neighborhood Hits	531	Shared Neighborhood Hits	63
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

RHG05_MOUSE
θ value	6.85773e-16 (rank : 18)	NC score	0.581015 (rank : 19)
Query Neighborhood Hits	228	Target Neighborhood Hits	165	Shared Neighborhood Hits	61
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_HUMAN
θ value	3.40345e-15 (rank : 19)	NC score	0.576708 (rank : 21)
Query Neighborhood Hits	228	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

DDEF2_HUMAN
θ value	4.44505e-15 (rank : 20)	NC score	0.469856 (rank : 72)
Query Neighborhood Hits	228	Target Neighborhood Hits	599	Shared Neighborhood Hits	72
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RHG09_HUMAN
θ value	5.8054e-15 (rank : 21)	NC score	0.627304 (rank : 6)
Query Neighborhood Hits	228	Target Neighborhood Hits	186	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CENB5_HUMAN
θ value	7.58209e-15 (rank : 22)	NC score	0.479010 (rank : 65)
Query Neighborhood Hits	228	Target Neighborhood Hits	395	Shared Neighborhood Hits	70
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

DDEF1_MOUSE
θ value	7.58209e-15 (rank : 23)	NC score	0.476104 (rank : 69)
Query Neighborhood Hits	228	Target Neighborhood Hits	592	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

TCGAP_HUMAN
θ value	7.58209e-15 (rank : 24)	NC score	0.513004 (rank : 50)
Query Neighborhood Hits	228	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	7.58209e-15 (rank : 25)	NC score	0.567930 (rank : 23)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	75
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

DDEF2_MOUSE
θ value	1.68911e-14 (rank : 26)	NC score	0.465311 (rank : 75)
Query Neighborhood Hits	228	Target Neighborhood Hits	625	Shared Neighborhood Hits	73
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CENB1_HUMAN
θ value	4.91457e-14 (rank : 27)	NC score	0.478589 (rank : 66)
Query Neighborhood Hits	228	Target Neighborhood Hits	383	Shared Neighborhood Hits	72
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

RHG07_MOUSE
θ value	4.91457e-14 (rank : 28)	NC score	0.523691 (rank : 43)
Query Neighborhood Hits	228	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

ABR_HUMAN
θ value	8.38298e-14 (rank : 29)	NC score	0.545812 (rank : 33)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
θ value	1.09485e-13 (rank : 30)	NC score	0.535814 (rank : 36)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CHIO_MOUSE
θ value	1.86753e-13 (rank : 31)	NC score	0.560465 (rank : 28)
Query Neighborhood Hits	228	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG12_HUMAN
θ value	2.43908e-13 (rank : 32)	NC score	0.587450 (rank : 15)
Query Neighborhood Hits	228	Target Neighborhood Hits	190	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CHIO_HUMAN
θ value	3.18553e-13 (rank : 33)	NC score	0.535179 (rank : 37)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	64
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG06_MOUSE
θ value	3.18553e-13 (rank : 34)	NC score	0.597523 (rank : 11)
Query Neighborhood Hits	228	Target Neighborhood Hits	105	Shared Neighborhood Hits	60
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG12_MOUSE
θ value	3.18553e-13 (rank : 35)	NC score	0.586170 (rank : 18)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SMP1L_HUMAN
θ value	3.18553e-13 (rank : 36)	NC score	0.563986 (rank : 25)
Query Neighborhood Hits	228	Target Neighborhood Hits	74	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	3.18553e-13 (rank : 37)	NC score	0.563112 (rank : 26)
Query Neighborhood Hits	228	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

RHG06_HUMAN
θ value	4.16044e-13 (rank : 38)	NC score	0.598379 (rank : 10)
Query Neighborhood Hits	228	Target Neighborhood Hits	114	Shared Neighborhood Hits	62
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG07_HUMAN
θ value	4.16044e-13 (rank : 39)	NC score	0.517763 (rank : 48)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

GMIP_MOUSE
θ value	5.43371e-13 (rank : 40)	NC score	0.599900 (rank : 8)
Query Neighborhood Hits	228	Target Neighborhood Hits	202	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

CHIN_MOUSE
θ value	7.09661e-13 (rank : 41)	NC score	0.538831 (rank : 34)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	65
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SMAP1_HUMAN
θ value	7.09661e-13 (rank : 42)	NC score	0.559108 (rank : 29)
Query Neighborhood Hits	228	Target Neighborhood Hits	98	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	7.09661e-13 (rank : 43)	NC score	0.560795 (rank : 27)
Query Neighborhood Hits	228	Target Neighborhood Hits	120	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CHIN_HUMAN
θ value	9.26847e-13 (rank : 44)	NC score	0.537171 (rank : 35)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RGAP1_HUMAN
θ value	9.26847e-13 (rank : 45)	NC score	0.598448 (rank : 9)
Query Neighborhood Hits	228	Target Neighborhood Hits	189	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	2.69671e-12 (rank : 46)	NC score	0.595648 (rank : 13)
Query Neighborhood Hits	228	Target Neighborhood Hits	185	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RBP1_MOUSE
θ value	3.52202e-12 (rank : 47)	NC score	0.547495 (rank : 32)
Query Neighborhood Hits	228	Target Neighborhood Hits	493	Shared Neighborhood Hits	68
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG18_HUMAN
θ value	4.59992e-12 (rank : 48)	NC score	0.586559 (rank : 16)
Query Neighborhood Hits	228	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

GIT2_MOUSE
θ value	6.00763e-12 (rank : 49)	NC score	0.436736 (rank : 78)
Query Neighborhood Hits	228	Target Neighborhood Hits	323	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GMIP_HUMAN
θ value	6.00763e-12 (rank : 50)	NC score	0.586411 (rank : 17)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	65
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

3BP1_HUMAN
θ value	1.33837e-11 (rank : 51)	NC score	0.567702 (rank : 24)
Query Neighborhood Hits	228	Target Neighborhood Hits	376	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

FNBP2_HUMAN
θ value	1.74796e-11 (rank : 52)	NC score	0.494087 (rank : 56)
Query Neighborhood Hits	228	Target Neighborhood Hits	432	Shared Neighborhood Hits	70
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RBP1_HUMAN
θ value	1.74796e-11 (rank : 53)	NC score	0.532787 (rank : 38)
Query Neighborhood Hits	228	Target Neighborhood Hits	521	Shared Neighborhood Hits	68
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

GIT2_HUMAN
θ value	2.28291e-11 (rank : 54)	NC score	0.436522 (rank : 79)
Query Neighborhood Hits	228	Target Neighborhood Hits	381	Shared Neighborhood Hits	49
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

OPHN1_MOUSE
θ value	2.28291e-11 (rank : 55)	NC score	0.600676 (rank : 7)
Query Neighborhood Hits	228	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG04_HUMAN
θ value	5.08577e-11 (rank : 56)	NC score	0.521227 (rank : 45)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	64
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CENA1_HUMAN
θ value	1.133e-10 (rank : 57)	NC score	0.553683 (rank : 31)
Query Neighborhood Hits	228	Target Neighborhood Hits	87	Shared Neighborhood Hits	59
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

OPHN1_HUMAN
θ value	1.133e-10 (rank : 58)	NC score	0.590799 (rank : 14)
Query Neighborhood Hits	228	Target Neighborhood Hits	161	Shared Neighborhood Hits	69
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

CENA2_HUMAN
θ value	1.47974e-10 (rank : 59)	NC score	0.529268 (rank : 40)
Query Neighborhood Hits	228	Target Neighborhood Hits	83	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

STA13_MOUSE
θ value	1.47974e-10 (rank : 60)	NC score	0.484667 (rank : 62)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

GIT1_HUMAN
θ value	2.52405e-10 (rank : 61)	NC score	0.424091 (rank : 82)
Query Neighborhood Hits	228	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	2.52405e-10 (rank : 62)	NC score	0.422639 (rank : 83)
Query Neighborhood Hits	228	Target Neighborhood Hits	341	Shared Neighborhood Hits	44
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

STA13_HUMAN
θ value	2.52405e-10 (rank : 63)	NC score	0.486887 (rank : 60)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

ARFG3_MOUSE
θ value	3.29651e-10 (rank : 64)	NC score	0.517091 (rank : 49)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RHG18_MOUSE
θ value	4.30538e-10 (rank : 65)	NC score	0.577395 (rank : 20)
Query Neighborhood Hits	228	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

SRGP2_HUMAN
θ value	7.34386e-10 (rank : 66)	NC score	0.503200 (rank : 52)
Query Neighborhood Hits	228	Target Neighborhood Hits	331	Shared Neighborhood Hits	65
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ARFG3_HUMAN
θ value	9.59137e-10 (rank : 67)	NC score	0.517919 (rank : 47)
Query Neighborhood Hits	228	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

STAR8_MOUSE
θ value	9.59137e-10 (rank : 68)	NC score	0.476982 (rank : 68)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
θ value	1.25267e-09 (rank : 69)	NC score	0.474670 (rank : 71)
Query Neighborhood Hits	228	Target Neighborhood Hits	216	Shared Neighborhood Hits	65
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CENA2_MOUSE
θ value	2.13673e-09 (rank : 70)	NC score	0.522451 (rank : 44)
Query Neighborhood Hits	228	Target Neighborhood Hits	68	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

SRGP2_MOUSE
θ value	2.13673e-09 (rank : 71)	NC score	0.496526 (rank : 54)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	65
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

3BP1_MOUSE
θ value	4.76016e-09 (rank : 72)	NC score	0.567952 (rank : 22)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	74
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG26_HUMAN
θ value	8.11959e-09 (rank : 73)	NC score	0.558597 (rank : 30)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SRGP1_HUMAN
θ value	8.11959e-09 (rank : 74)	NC score	0.490862 (rank : 58)
Query Neighborhood Hits	228	Target Neighborhood Hits	390	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RHG25_MOUSE
θ value	4.0297e-08 (rank : 75)	NC score	0.519417 (rank : 46)
Query Neighborhood Hits	228	Target Neighborhood Hits	492	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
θ value	6.87365e-08 (rank : 76)	NC score	0.479564 (rank : 64)
Query Neighborhood Hits	228	Target Neighborhood Hits	550	Shared Neighborhood Hits	96
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TAGAP_HUMAN
θ value	5.81887e-07 (rank : 77)	NC score	0.528746 (rank : 41)
Query Neighborhood Hits	228	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
θ value	5.81887e-07 (rank : 78)	NC score	0.524399 (rank : 42)
Query Neighborhood Hits	228	Target Neighborhood Hits	83	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG01_HUMAN
θ value	7.59969e-07 (rank : 79)	NC score	0.529588 (rank : 39)
Query Neighborhood Hits	228	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

ARFG1_MOUSE
θ value	1.29631e-06 (rank : 80)	NC score	0.501444 (rank : 53)
Query Neighborhood Hits	228	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_HUMAN
θ value	2.88788e-06 (rank : 81)	NC score	0.488597 (rank : 59)
Query Neighborhood Hits	228	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

PKHA1_HUMAN
θ value	7.1131e-05 (rank : 82)	NC score	0.223200 (rank : 94)
Query Neighborhood Hits	228	Target Neighborhood Hits	127	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

NUPL_HUMAN
θ value	9.29e-05 (rank : 83)	NC score	0.372094 (rank : 84)
Query Neighborhood Hits	228	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	9.29e-05 (rank : 84)	NC score	0.369220 (rank : 85)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

CE005_HUMAN
θ value	0.000158464 (rank : 85)	NC score	0.431988 (rank : 80)
Query Neighborhood Hits	228	Target Neighborhood Hits	213	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

HRBL_HUMAN
θ value	0.00020696 (rank : 86)	NC score	0.328998 (rank : 86)
Query Neighborhood Hits	228	Target Neighborhood Hits	179	Shared Neighborhood Hits	43
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_MOUSE
θ value	0.00020696 (rank : 87)	NC score	0.314588 (rank : 89)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	43
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

DGKH_HUMAN
θ value	0.000270298 (rank : 88)	NC score	0.135747 (rank : 102)
Query Neighborhood Hits	228	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

P85A_HUMAN
θ value	0.000270298 (rank : 89)	NC score	0.281422 (rank : 92)
Query Neighborhood Hits	228	Target Neighborhood Hits	479	Shared Neighborhood Hits	62
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CE005_MOUSE
θ value	0.000461057 (rank : 90)	NC score	0.427712 (rank : 81)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

P85A_MOUSE
θ value	0.000461057 (rank : 91)	NC score	0.275815 (rank : 93)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	63
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

EPHB6_MOUSE
θ value	0.000602161 (rank : 92)	NC score	0.078470 (rank : 125)
Query Neighborhood Hits	228	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHB6_HUMAN
θ value	0.000786445 (rank : 93)	NC score	0.079383 (rank : 123)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	45
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

RHG08_HUMAN
θ value	0.000786445 (rank : 94)	NC score	0.491766 (rank : 57)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

EPHA4_HUMAN
θ value	0.00102713 (rank : 95)	NC score	0.069439 (rank : 133)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	43
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

PKHA1_MOUSE
θ value	0.00102713 (rank : 96)	NC score	0.216023 (rank : 95)
Query Neighborhood Hits	228	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

EPHA4_MOUSE
θ value	0.00175202 (rank : 97)	NC score	0.068117 (rank : 139)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA8_MOUSE
θ value	0.00175202 (rank : 98)	NC score	0.068262 (rank : 138)
Query Neighborhood Hits	228	Target Neighborhood Hits	969	Shared Neighborhood Hits	44
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

RHG08_MOUSE
θ value	0.00175202 (rank : 99)	NC score	0.494323 (rank : 55)
Query Neighborhood Hits	228	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

DGKD_HUMAN
θ value	0.00228821 (rank : 100)	NC score	0.120035 (rank : 103)
Query Neighborhood Hits	228	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

AATK_HUMAN
θ value	0.00298849 (rank : 101)	NC score	0.035327 (rank : 229)
Query Neighborhood Hits	228	Target Neighborhood Hits	1243	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EPHA5_HUMAN
θ value	0.00298849 (rank : 102)	NC score	0.065952 (rank : 145)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	48
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PKHA2_MOUSE
θ value	0.00298849 (rank : 103)	NC score	0.183719 (rank : 96)
Query Neighborhood Hits	228	Target Neighborhood Hits	116	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

EPHA1_MOUSE
θ value	0.00509761 (rank : 104)	NC score	0.068786 (rank : 134)
Query Neighborhood Hits	228	Target Neighborhood Hits	958	Shared Neighborhood Hits	43
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

HSF1_MOUSE
θ value	0.00509761 (rank : 105)	NC score	0.067230 (rank : 141)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	19
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

EPHA8_HUMAN
θ value	0.00869519 (rank : 106)	NC score	0.066119 (rank : 143)
Query Neighborhood Hits	228	Target Neighborhood Hits	956	Shared Neighborhood Hits	43
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

TNKS1_HUMAN
θ value	0.00869519 (rank : 107)	NC score	0.080473 (rank : 121)
Query Neighborhood Hits	228	Target Neighborhood Hits	477	Shared Neighborhood Hits	58
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

EPHB1_HUMAN
θ value	0.0148317 (rank : 108)	NC score	0.063899 (rank : 151)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHA1_HUMAN
θ value	0.0193708 (rank : 109)	NC score	0.066704 (rank : 142)
Query Neighborhood Hits	228	Target Neighborhood Hits	997	Shared Neighborhood Hits	41
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

HSF1_HUMAN
θ value	0.0252991 (rank : 110)	NC score	0.051503 (rank : 205)
Query Neighborhood Hits	228	Target Neighborhood Hits	163	Shared Neighborhood Hits	7
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

MDC1_MOUSE
θ value	0.0252991 (rank : 111)	NC score	0.045068 (rank : 218)
Query Neighborhood Hits	228	Target Neighborhood Hits	998	Shared Neighborhood Hits	39
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

EPHA5_MOUSE
θ value	0.0330416 (rank : 112)	NC score	0.055558 (rank : 182)
Query Neighborhood Hits	228	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA7_HUMAN
θ value	0.0330416 (rank : 113)	NC score	0.064803 (rank : 148)
Query Neighborhood Hits	228	Target Neighborhood Hits	1053	Shared Neighborhood Hits	47
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

CSKI1_HUMAN
θ value	0.0431538 (rank : 114)	NC score	0.098225 (rank : 107)
Query Neighborhood Hits	228	Target Neighborhood Hits	997	Shared Neighborhood Hits	103
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	0.0431538 (rank : 115)	NC score	0.095244 (rank : 109)
Query Neighborhood Hits	228	Target Neighborhood Hits	1031	Shared Neighborhood Hits	96
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MKL1_MOUSE
θ value	0.0431538 (rank : 116)	NC score	0.046802 (rank : 216)
Query Neighborhood Hits	228	Target Neighborhood Hits	667	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

TNKS2_HUMAN
θ value	0.0431538 (rank : 117)	NC score	0.072586 (rank : 130)
Query Neighborhood Hits	228	Target Neighborhood Hits	361	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

I20L2_HUMAN
θ value	0.0563607 (rank : 118)	NC score	0.047738 (rank : 215)
Query Neighborhood Hits	228	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H9L3, Q64KA2	Gene names	ISG20L2
Domain Architecture
Description	Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-).

EPHA7_MOUSE
θ value	0.0736092 (rank : 119)	NC score	0.064007 (rank : 150)
Query Neighborhood Hits	228	Target Neighborhood Hits	1025	Shared Neighborhood Hits	44
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB2_HUMAN
θ value	0.0736092 (rank : 120)	NC score	0.064325 (rank : 149)
Query Neighborhood Hits	228	Target Neighborhood Hits	983	Shared Neighborhood Hits	44
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	0.0736092 (rank : 121)	NC score	0.063824 (rank : 153)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

TULP4_HUMAN
θ value	0.0736092 (rank : 122)	NC score	0.038716 (rank : 223)
Query Neighborhood Hits	228	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

CSKI2_MOUSE
θ value	0.0961366 (rank : 123)	NC score	0.100515 (rank : 105)
Query Neighborhood Hits	228	Target Neighborhood Hits	812	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA2_MOUSE
θ value	0.0961366 (rank : 124)	NC score	0.063230 (rank : 155)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	44
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

PKHA6_MOUSE
θ value	0.0961366 (rank : 125)	NC score	0.155377 (rank : 100)
Query Neighborhood Hits	228	Target Neighborhood Hits	591	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CSKI2_HUMAN
θ value	0.125558 (rank : 126)	NC score	0.100377 (rank : 106)
Query Neighborhood Hits	228	Target Neighborhood Hits	747	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHB4_MOUSE
θ value	0.125558 (rank : 127)	NC score	0.060547 (rank : 166)
Query Neighborhood Hits	228	Target Neighborhood Hits	1013	Shared Neighborhood Hits	45
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

JADE2_MOUSE
θ value	0.125558 (rank : 128)	NC score	0.027787 (rank : 236)
Query Neighborhood Hits	228	Target Neighborhood Hits	560	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

PKHA2_HUMAN
θ value	0.125558 (rank : 129)	NC score	0.160173 (rank : 99)
Query Neighborhood Hits	228	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

EPHA6_HUMAN
θ value	0.163984 (rank : 130)	NC score	0.070559 (rank : 132)
Query Neighborhood Hits	228	Target Neighborhood Hits	959	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHB4_HUMAN
θ value	0.163984 (rank : 131)	NC score	0.060013 (rank : 167)
Query Neighborhood Hits	228	Target Neighborhood Hits	1056	Shared Neighborhood Hits	45
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

FARP1_HUMAN
θ value	0.163984 (rank : 132)	NC score	0.048905 (rank : 214)
Query Neighborhood Hits	228	Target Neighborhood Hits	241	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MYO10_HUMAN
θ value	0.163984 (rank : 133)	NC score	0.073364 (rank : 129)
Query Neighborhood Hits	228	Target Neighborhood Hits	920	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

SON_HUMAN
θ value	0.163984 (rank : 134)	NC score	0.036447 (rank : 226)
Query Neighborhood Hits	228	Target Neighborhood Hits	1568	Shared Neighborhood Hits	59
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CECR2_HUMAN
θ value	0.21417 (rank : 135)	NC score	0.029834 (rank : 233)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

EPHA2_HUMAN
θ value	0.21417 (rank : 136)	NC score	0.062643 (rank : 159)
Query Neighborhood Hits	228	Target Neighborhood Hits	1021	Shared Neighborhood Hits	44
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

PKHA6_HUMAN
θ value	0.21417 (rank : 137)	NC score	0.151640 (rank : 101)
Query Neighborhood Hits	228	Target Neighborhood Hits	556	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

EPHA6_MOUSE
θ value	0.279714 (rank : 138)	NC score	0.068365 (rank : 137)
Query Neighborhood Hits	228	Target Neighborhood Hits	946	Shared Neighborhood Hits	44
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHB3_HUMAN
θ value	0.279714 (rank : 139)	NC score	0.062808 (rank : 158)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	45
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	0.365318 (rank : 140)	NC score	0.061842 (rank : 163)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	43
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

SYNG_MOUSE
θ value	0.365318 (rank : 141)	NC score	0.036331 (rank : 228)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

CYH1_HUMAN
θ value	0.47712 (rank : 142)	NC score	0.083728 (rank : 118)
Query Neighborhood Hits	228	Target Neighborhood Hits	184	Shared Neighborhood Hits	40
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.47712 (rank : 143)	NC score	0.084639 (rank : 116)
Query Neighborhood Hits	228	Target Neighborhood Hits	176	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH2_HUMAN
θ value	0.47712 (rank : 144)	NC score	0.080633 (rank : 119)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.47712 (rank : 145)	NC score	0.080516 (rank : 120)
Query Neighborhood Hits	228	Target Neighborhood Hits	171	Shared Neighborhood Hits	41
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_HUMAN
θ value	0.47712 (rank : 146)	NC score	0.078575 (rank : 124)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

NCOA6_HUMAN
θ value	0.47712 (rank : 147)	NC score	0.040814 (rank : 221)
Query Neighborhood Hits	228	Target Neighborhood Hits	1202	Shared Neighborhood Hits	51
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SPR1B_MOUSE
θ value	0.47712 (rank : 148)	NC score	0.022800 (rank : 241)
Query Neighborhood Hits	228	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

MDC1_HUMAN
θ value	0.62314 (rank : 149)	NC score	0.037813 (rank : 224)
Query Neighborhood Hits	228	Target Neighborhood Hits	1446	Shared Neighborhood Hits	55
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NCOA6_MOUSE
θ value	0.62314 (rank : 150)	NC score	0.044017 (rank : 220)
Query Neighborhood Hits	228	Target Neighborhood Hits	1076	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SEPT9_MOUSE
θ value	0.62314 (rank : 151)	NC score	0.015588 (rank : 255)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	15
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

CO039_MOUSE
θ value	0.813845 (rank : 152)	NC score	0.022292 (rank : 244)
Query Neighborhood Hits	228	Target Neighborhood Hits	445	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

EPHAA_HUMAN
θ value	0.813845 (rank : 153)	NC score	0.065956 (rank : 144)
Query Neighborhood Hits	228	Target Neighborhood Hits	960	Shared Neighborhood Hits	42
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FARP2_HUMAN
θ value	0.813845 (rank : 154)	NC score	0.040281 (rank : 222)
Query Neighborhood Hits	228	Target Neighborhood Hits	240	Shared Neighborhood Hits	37
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MTMRD_HUMAN
θ value	0.813845 (rank : 155)	NC score	0.044362 (rank : 219)
Query Neighborhood Hits	228	Target Neighborhood Hits	135	Shared Neighborhood Hits	33
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

SHAN2_MOUSE
θ value	0.813845 (rank : 156)	NC score	0.050588 (rank : 209)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRRM2_HUMAN
θ value	0.813845 (rank : 157)	NC score	0.033050 (rank : 230)
Query Neighborhood Hits	228	Target Neighborhood Hits	1296	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CNKR1_HUMAN
θ value	1.06291 (rank : 158)	NC score	0.073885 (rank : 128)
Query Neighborhood Hits	228	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

INT1_HUMAN
θ value	1.06291 (rank : 159)	NC score	0.017603 (rank : 251)
Query Neighborhood Hits	228	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

CBL_HUMAN
θ value	1.38821 (rank : 160)	NC score	0.011010 (rank : 264)
Query Neighborhood Hits	228	Target Neighborhood Hits	353	Shared Neighborhood Hits	16
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

FARP2_MOUSE
θ value	1.38821 (rank : 161)	NC score	0.036976 (rank : 225)
Query Neighborhood Hits	228	Target Neighborhood Hits	209	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CYH3_MOUSE
θ value	1.81305 (rank : 162)	NC score	0.071474 (rank : 131)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

FMN2_HUMAN
θ value	1.81305 (rank : 163)	NC score	0.022283 (rank : 245)
Query Neighborhood Hits	228	Target Neighborhood Hits	484	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

JIP3_HUMAN
θ value	1.81305 (rank : 164)	NC score	0.011839 (rank : 262)
Query Neighborhood Hits	228	Target Neighborhood Hits	1039	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

SASH1_HUMAN
θ value	1.81305 (rank : 165)	NC score	0.062469 (rank : 161)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

EPO_MOUSE
θ value	2.36792 (rank : 166)	NC score	0.020136 (rank : 247)
Query Neighborhood Hits	228	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P07321	Gene names	Epo
Domain Architecture
Description	Erythropoietin precursor.

MLL3_MOUSE
θ value	2.36792 (rank : 167)	NC score	0.014623 (rank : 257)
Query Neighborhood Hits	228	Target Neighborhood Hits	1399	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SPA11_HUMAN
θ value	2.36792 (rank : 168)	NC score	0.001365 (rank : 280)
Query Neighborhood Hits	228	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q86U17	Gene names	SERPINA11
Domain Architecture	No domain graphic available
Description	Serpin A11 precursor.

WDR22_HUMAN
θ value	2.36792 (rank : 169)	NC score	0.005169 (rank : 276)
Query Neighborhood Hits	228	Target Neighborhood Hits	328	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

3BP2_HUMAN
θ value	3.0926 (rank : 170)	NC score	0.076596 (rank : 126)
Query Neighborhood Hits	228	Target Neighborhood Hits	296	Shared Neighborhood Hits	50
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CADH2_HUMAN
θ value	3.0926 (rank : 171)	NC score	-0.000958 (rank : 283)
Query Neighborhood Hits	228	Target Neighborhood Hits	161	Shared Neighborhood Hits	2
SwissProt Accessions	P19022, Q14923	Gene names	CDH2, CDHN, NCAD
Domain Architecture
Description	Cadherin-2 precursor (Neural-cadherin) (N-cadherin) (CDw325 antigen).

IRF3_HUMAN
θ value	3.0926 (rank : 172)	NC score	0.013446 (rank : 260)
Query Neighborhood Hits	228	Target Neighborhood Hits	129	Shared Neighborhood Hits	8
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

K1688_MOUSE
θ value	3.0926 (rank : 173)	NC score	0.306359 (rank : 90)
Query Neighborhood Hits	228	Target Neighborhood Hits	188	Shared Neighborhood Hits	68
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

MYLK_MOUSE
θ value	3.0926 (rank : 174)	NC score	0.009623 (rank : 270)
Query Neighborhood Hits	228	Target Neighborhood Hits	1489	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PCLO_HUMAN
θ value	3.0926 (rank : 175)	NC score	0.029663 (rank : 234)
Query Neighborhood Hits	228	Target Neighborhood Hits	2046	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RAPH1_HUMAN
θ value	3.0926 (rank : 176)	NC score	0.054688 (rank : 184)
Query Neighborhood Hits	228	Target Neighborhood Hits	593	Shared Neighborhood Hits	53
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SHAN2_HUMAN
θ value	3.0926 (rank : 177)	NC score	0.045333 (rank : 217)
Query Neighborhood Hits	228	Target Neighborhood Hits	346	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SNAG_MOUSE
θ value	3.0926 (rank : 178)	NC score	0.027984 (rank : 235)
Query Neighborhood Hits	228	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWZ7, Q3TPT4	Gene names	Napg, Snapg
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

SYNG_HUMAN
θ value	3.0926 (rank : 179)	NC score	0.023394 (rank : 239)
Query Neighborhood Hits	228	Target Neighborhood Hits	160	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

TESK2_HUMAN
θ value	3.0926 (rank : 180)	NC score	0.018999 (rank : 249)
Query Neighborhood Hits	228	Target Neighborhood Hits	851	Shared Neighborhood Hits	32
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ZN236_HUMAN
θ value	3.0926 (rank : 181)	NC score	-0.007024 (rank : 287)
Query Neighborhood Hits	228	Target Neighborhood Hits	844	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UL36, Q9UL37	Gene names	ZNF236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 236.

GRB7_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.022413 (rank : 243)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	18
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

JHD3C_HUMAN
θ value	4.03905 (rank : 183)	NC score	0.006719 (rank : 272)
Query Neighborhood Hits	228	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H3R0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3	Gene names	JMJD2C, GASC1, JHDM3C, KIAA0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein).

RTP3_MOUSE
θ value	4.03905 (rank : 184)	NC score	0.032228 (rank : 231)
Query Neighborhood Hits	228	Target Neighborhood Hits	374	Shared Neighborhood Hits	28
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SPR1A_MOUSE
θ value	4.03905 (rank : 185)	NC score	0.018350 (rank : 250)
Query Neighborhood Hits	228	Target Neighborhood Hits	343	Shared Neighborhood Hits	18
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SSBP4_HUMAN
θ value	4.03905 (rank : 186)	NC score	0.021132 (rank : 246)
Query Neighborhood Hits	228	Target Neighborhood Hits	753	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

SVIL_MOUSE
θ value	4.03905 (rank : 187)	NC score	0.014341 (rank : 258)
Query Neighborhood Hits	228	Target Neighborhood Hits	439	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TF3C2_HUMAN
θ value	4.03905 (rank : 188)	NC score	0.010205 (rank : 267)
Query Neighborhood Hits	228	Target Neighborhood Hits	168	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

TPO_MOUSE
θ value	4.03905 (rank : 189)	NC score	0.015583 (rank : 256)
Query Neighborhood Hits	228	Target Neighborhood Hits	258	Shared Neighborhood Hits	16
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

ABCA5_MOUSE
θ value	5.27518 (rank : 190)	NC score	0.003103 (rank : 278)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K448, Q3TE17, Q3UUB4, Q6P1Y0, Q6ZPG4, Q810C7, Q8BM46, Q8BXG7	Gene names	Abca5, Kiaa1888
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 5.

CENPF_HUMAN
θ value	5.27518 (rank : 191)	NC score	0.005628 (rank : 275)
Query Neighborhood Hits	228	Target Neighborhood Hits	1932	Shared Neighborhood Hits	40
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CN044_HUMAN
θ value	5.27518 (rank : 192)	NC score	0.008149 (rank : 271)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MY7	Gene names	C14orf44
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf44.

FAK1_MOUSE
θ value	5.27518 (rank : 193)	NC score	0.030587 (rank : 232)
Query Neighborhood Hits	228	Target Neighborhood Hits	850	Shared Neighborhood Hits	30
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

K1688_HUMAN
θ value	5.27518 (rank : 194)	NC score	0.297126 (rank : 91)
Query Neighborhood Hits	228	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

OPA1_HUMAN
θ value	5.27518 (rank : 195)	NC score	0.006274 (rank : 273)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

PLEK_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.074690 (rank : 127)
Query Neighborhood Hits	228	Target Neighborhood Hits	110	Shared Neighborhood Hits	40
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PSL1_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.017551 (rank : 252)
Query Neighborhood Hits	228	Target Neighborhood Hits	650	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

R3HD2_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.017276 (rank : 253)
Query Neighborhood Hits	228	Target Neighborhood Hits	397	Shared Neighborhood Hits	17
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

SNAG_HUMAN
θ value	5.27518 (rank : 199)	NC score	0.024492 (rank : 237)
Query Neighborhood Hits	228	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q99747, Q9BUV1	Gene names	NAPG, SNAPG
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

SP6_HUMAN
θ value	5.27518 (rank : 200)	NC score	-0.006126 (rank : 284)
Query Neighborhood Hits	228	Target Neighborhood Hits	700	Shared Neighborhood Hits	5
SwissProt Accessions	Q3SY56	Gene names	SP6, KLF14
Domain Architecture	No domain graphic available
Description	Transcription factor Sp6 (Krueppel-like factor 14).

STAU2_HUMAN
θ value	5.27518 (rank : 201)	NC score	0.010900 (rank : 265)
Query Neighborhood Hits	228	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NUL3, Q6AHY7, Q96HM0, Q96HM1, Q9NVI5, Q9UGG6	Gene names	STAU2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

STAU2_MOUSE
θ value	5.27518 (rank : 202)	NC score	0.010837 (rank : 266)
Query Neighborhood Hits	228	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CJ67, Q8BSY8, Q8CJ66, Q8R175, Q91Z19, Q9D5N7	Gene names	Stau2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

UBP44_HUMAN
θ value	5.27518 (rank : 203)	NC score	0.002651 (rank : 279)
Query Neighborhood Hits	228	Target Neighborhood Hits	91	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0E7	Gene names	USP44
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.1.2.15) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) (Deubiquitinating enzyme 44).

CNKR2_HUMAN
θ value	6.88961 (rank : 204)	NC score	0.052632 (rank : 194)
Query Neighborhood Hits	228	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	6.88961 (rank : 205)	NC score	0.053050 (rank : 190)
Query Neighborhood Hits	228	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

FBX34_MOUSE
θ value	6.88961 (rank : 206)	NC score	0.006229 (rank : 274)
Query Neighborhood Hits	228	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

MIB1_MOUSE
θ value	6.88961 (rank : 207)	NC score	0.036420 (rank : 227)
Query Neighborhood Hits	228	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

PKDRE_HUMAN
θ value	6.88961 (rank : 208)	NC score	0.009709 (rank : 269)
Query Neighborhood Hits	228	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PLCG1_HUMAN
θ value	6.88961 (rank : 209)	NC score	0.023004 (rank : 240)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SALL1_HUMAN
θ value	6.88961 (rank : 210)	NC score	-0.006217 (rank : 285)
Query Neighborhood Hits	228	Target Neighborhood Hits	821	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

SAPS1_HUMAN
θ value	6.88961 (rank : 211)	NC score	0.022484 (rank : 242)
Query Neighborhood Hits	228	Target Neighborhood Hits	704	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SP6_MOUSE
θ value	6.88961 (rank : 212)	NC score	-0.006320 (rank : 286)
Query Neighborhood Hits	228	Target Neighborhood Hits	704	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESX2, Q6VM22	Gene names	Sp6, Epfn, Klf14
Domain Architecture	No domain graphic available
Description	Transcription factor Sp6 (Krueppel-like factor 14) (Epiprofin).

ZN318_HUMAN
θ value	6.88961 (rank : 213)	NC score	0.017158 (rank : 254)
Query Neighborhood Hits	228	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

3BP2_MOUSE
θ value	8.99809 (rank : 214)	NC score	0.065142 (rank : 146)
Query Neighborhood Hits	228	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANKS1_MOUSE
θ value	8.99809 (rank : 215)	NC score	0.057283 (rank : 178)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	62
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

CYH4_HUMAN
θ value	8.99809 (rank : 216)	NC score	0.062210 (rank : 162)
Query Neighborhood Hits	228	Target Neighborhood Hits	135	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	8.99809 (rank : 217)	NC score	0.062885 (rank : 157)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

GAB2_MOUSE
θ value	8.99809 (rank : 218)	NC score	0.068562 (rank : 135)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GOGA6_HUMAN
θ value	8.99809 (rank : 219)	NC score	0.001320 (rank : 281)
Query Neighborhood Hits	228	Target Neighborhood Hits	1007	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

K1802_HUMAN
θ value	8.99809 (rank : 220)	NC score	0.020038 (rank : 248)
Query Neighborhood Hits	228	Target Neighborhood Hits	1378	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

KCNB2_HUMAN
θ value	8.99809 (rank : 221)	NC score	-0.000171 (rank : 282)
Query Neighborhood Hits	228	Target Neighborhood Hits	212	Shared Neighborhood Hits	7
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

MAP1A_HUMAN
θ value	8.99809 (rank : 222)	NC score	0.011409 (rank : 263)
Query Neighborhood Hits	228	Target Neighborhood Hits	1626	Shared Neighborhood Hits	46
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NEK1_MOUSE
θ value	8.99809 (rank : 223)	NC score	0.010049 (rank : 268)
Query Neighborhood Hits	228	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PKHF1_MOUSE
θ value	8.99809 (rank : 224)	NC score	0.013542 (rank : 259)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PLCG1_MOUSE
θ value	8.99809 (rank : 225)	NC score	0.023521 (rank : 238)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	24
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SASH1_MOUSE
θ value	8.99809 (rank : 226)	NC score	0.059264 (rank : 169)
Query Neighborhood Hits	228	Target Neighborhood Hits	263	Shared Neighborhood Hits	51
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SEZ6L_HUMAN
θ value	8.99809 (rank : 227)	NC score	0.003654 (rank : 277)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

TXLNB_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.012553 (rank : 261)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

ANK1_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.050127 (rank : 212)
Query Neighborhood Hits	228	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK1_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.050337 (rank : 210)
Query Neighborhood Hits	228	Target Neighborhood Hits	430	Shared Neighborhood Hits	29
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANKR2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.050950 (rank : 207)
Query Neighborhood Hits	228	Target Neighborhood Hits	321	Shared Neighborhood Hits	26
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKR6_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.051795 (rank : 202)
Query Neighborhood Hits	228	Target Neighborhood Hits	439	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANKS1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.052766 (rank : 193)
Query Neighborhood Hits	228	Target Neighborhood Hits	438	Shared Neighborhood Hits	61
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANR10_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.051517 (rank : 204)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR37_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.059146 (rank : 170)
Query Neighborhood Hits	228	Target Neighborhood Hits	247	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR37_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.068487 (rank : 136)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR39_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.061715 (rank : 164)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.062607 (rank : 160)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR41_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.068011 (rank : 140)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR42_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.052132 (rank : 198)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR46_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.063891 (rank : 152)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.063301 (rank : 154)
Query Neighborhood Hits	228	Target Neighborhood Hits	274	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANS4B_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.053593 (rank : 187)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANS4B_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.057834 (rank : 176)
Query Neighborhood Hits	228	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB10_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.051605 (rank : 203)
Query Neighborhood Hits	228	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CDN2D_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.051811 (rank : 201)
Query Neighborhood Hits	228	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CT086_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.080000 (rank : 122)
Query Neighborhood Hits	228	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

DAPP1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.089643 (rank : 114)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.091645 (rank : 112)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKK_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.058145 (rank : 174)
Query Neighborhood Hits	228	Target Neighborhood Hits	378	Shared Neighborhood Hits	46
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DP13A_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.094995 (rank : 110)
Query Neighborhood Hits	228	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.092285 (rank : 111)
Query Neighborhood Hits	228	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.084494 (rank : 117)
Query Neighborhood Hits	228	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.090268 (rank : 113)
Query Neighborhood Hits	228	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.052194 (rank : 197)
Query Neighborhood Hits	228	Target Neighborhood Hits	1005	Shared Neighborhood Hits	36
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.052849 (rank : 192)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	37
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

GAB1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.054614 (rank : 185)
Query Neighborhood Hits	228	Target Neighborhood Hits	279	Shared Neighborhood Hits	31
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.064812 (rank : 147)
Query Neighborhood Hits	228	Target Neighborhood Hits	188	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GABP2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.056672 (rank : 179)
Query Neighborhood Hits	228	Target Neighborhood Hits	454	Shared Neighborhood Hits	26
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.056577 (rank : 180)
Query Neighborhood Hits	228	Target Neighborhood Hits	429	Shared Neighborhood Hits	27
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GABP3_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.058796 (rank : 172)
Query Neighborhood Hits	228	Target Neighborhood Hits	330	Shared Neighborhood Hits	26
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

GRP3_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.051892 (rank : 199)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HECD1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.051020 (rank : 206)
Query Neighborhood Hits	228	Target Neighborhood Hits	371	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

I5P2_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.172722 (rank : 98)
Query Neighborhood Hits	228	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

IASPP_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.052319 (rank : 195)
Query Neighborhood Hits	228	Target Neighborhood Hits	688	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.058094 (rank : 175)
Query Neighborhood Hits	228	Target Neighborhood Hits	1024	Shared Neighborhood Hits	60
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBB_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.053497 (rank : 188)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

IKBB_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.060911 (rank : 165)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

ILK1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.055262 (rank : 183)
Query Neighborhood Hits	228	Target Neighborhood Hits	857	Shared Neighborhood Hits	55
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.056282 (rank : 181)
Query Neighborhood Hits	228	Target Neighborhood Hits	848	Shared Neighborhood Hits	55
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.054505 (rank : 186)
Query Neighborhood Hits	228	Target Neighborhood Hits	858	Shared Neighborhood Hits	55
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

MTPN_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.051885 (rank : 200)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.053393 (rank : 189)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MYPT1_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.050855 (rank : 208)
Query Neighborhood Hits	228	Target Neighborhood Hits	539	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

OCRL_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.174855 (rank : 97)
Query Neighborhood Hits	228	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

P85B_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.063143 (rank : 156)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCTL_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.052259 (rank : 196)
Query Neighborhood Hits	228	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.052870 (rank : 191)
Query Neighborhood Hits	228	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PKHA4_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.096004 (rank : 108)
Query Neighborhood Hits	228	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.104568 (rank : 104)
Query Neighborhood Hits	228	Target Neighborhood Hits	202	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.087279 (rank : 115)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.059386 (rank : 168)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.057455 (rank : 177)
Query Neighborhood Hits	228	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.059127 (rank : 171)
Query Neighborhood Hits	228	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

SHAN1_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.058368 (rank : 173)
Query Neighborhood Hits	228	Target Neighborhood Hits	1041	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

USH1G_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.050119 (rank : 213)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.050295 (rank : 211)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

Hits sorted by NC score

CEND3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	228
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.988977 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	228	Target Neighborhood Hits	275	Shared Neighborhood Hits	184
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND2_HUMAN
NC score	0.951394 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	111
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND1_MOUSE
NC score	0.945697 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	228	Target Neighborhood Hits	260	Shared Neighborhood Hits	139
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.939446 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RHG09_HUMAN
NC score	0.627304 (rank : 6)	θ value	5.8054e-15 (rank : 21)
Query Neighborhood Hits	228	Target Neighborhood Hits	186	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

OPHN1_MOUSE
NC score	0.600676 (rank : 7)	θ value	2.28291e-11 (rank : 55)
Query Neighborhood Hits	228	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

GMIP_MOUSE
NC score	0.599900 (rank : 8)	θ value	5.43371e-13 (rank : 40)
Query Neighborhood Hits	228	Target Neighborhood Hits	202	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RGAP1_HUMAN
NC score	0.598448 (rank : 9)	θ value	9.26847e-13 (rank : 45)
Query Neighborhood Hits	228	Target Neighborhood Hits	189	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG06_HUMAN
NC score	0.598379 (rank : 10)	θ value	4.16044e-13 (rank : 38)
Query Neighborhood Hits	228	Target Neighborhood Hits	114	Shared Neighborhood Hits	62
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.597523 (rank : 11)	θ value	3.18553e-13 (rank : 34)
Query Neighborhood Hits	228	Target Neighborhood Hits	105	Shared Neighborhood Hits	60
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

GRLF1_HUMAN
NC score	0.595937 (rank : 12)	θ value	4.02038e-16 (rank : 14)
Query Neighborhood Hits	228	Target Neighborhood Hits	167	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

RGAP1_MOUSE
NC score	0.595648 (rank : 13)	θ value	2.69671e-12 (rank : 46)
Query Neighborhood Hits	228	Target Neighborhood Hits	185	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

OPHN1_HUMAN
NC score	0.590799 (rank : 14)	θ value	1.133e-10 (rank : 58)
Query Neighborhood Hits	228	Target Neighborhood Hits	161	Shared Neighborhood Hits	69
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG12_HUMAN
NC score	0.587450 (rank : 15)	θ value	2.43908e-13 (rank : 32)
Query Neighborhood Hits	228	Target Neighborhood Hits	190	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG18_HUMAN
NC score	0.586559 (rank : 16)	θ value	4.59992e-12 (rank : 48)
Query Neighborhood Hits	228	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

GMIP_HUMAN
NC score	0.586411 (rank : 17)	θ value	6.00763e-12 (rank : 50)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	65
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG12_MOUSE
NC score	0.586170 (rank : 18)	θ value	3.18553e-13 (rank : 35)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG05_MOUSE
NC score	0.581015 (rank : 19)	θ value	6.85773e-16 (rank : 18)
Query Neighborhood Hits	228	Target Neighborhood Hits	165	Shared Neighborhood Hits	61
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_MOUSE
NC score	0.577395 (rank : 20)	θ value	4.30538e-10 (rank : 65)
Query Neighborhood Hits	228	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG05_HUMAN
NC score	0.576708 (rank : 21)	θ value	3.40345e-15 (rank : 19)
Query Neighborhood Hits	228	Target Neighborhood Hits	158	Shared Neighborhood Hits	61
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

3BP1_MOUSE
NC score	0.567952 (rank : 22)	θ value	4.76016e-09 (rank : 72)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	74
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TCGAP_MOUSE
NC score	0.567930 (rank : 23)	θ value	7.58209e-15 (rank : 25)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	75
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

3BP1_HUMAN
NC score	0.567702 (rank : 24)	θ value	1.33837e-11 (rank : 51)
Query Neighborhood Hits	228	Target Neighborhood Hits	376	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

SMP1L_HUMAN
NC score	0.563986 (rank : 25)	θ value	3.18553e-13 (rank : 36)
Query Neighborhood Hits	228	Target Neighborhood Hits	74	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
NC score	0.563112 (rank : 26)	θ value	3.18553e-13 (rank : 37)
Query Neighborhood Hits	228	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMAP1_MOUSE
NC score	0.560795 (rank : 27)	θ value	7.09661e-13 (rank : 43)
Query Neighborhood Hits	228	Target Neighborhood Hits	120	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CHIO_MOUSE
NC score	0.560465 (rank : 28)	θ value	1.86753e-13 (rank : 31)
Query Neighborhood Hits	228	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SMAP1_HUMAN
NC score	0.559108 (rank : 29)	θ value	7.09661e-13 (rank : 42)
Query Neighborhood Hits	228	Target Neighborhood Hits	98	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

RHG26_HUMAN
NC score	0.558597 (rank : 30)	θ value	8.11959e-09 (rank : 73)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CENA1_HUMAN
NC score	0.553683 (rank : 31)	θ value	1.133e-10 (rank : 57)
Query Neighborhood Hits	228	Target Neighborhood Hits	87	Shared Neighborhood Hits	59
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

RBP1_MOUSE
NC score	0.547495 (rank : 32)	θ value	3.52202e-12 (rank : 47)
Query Neighborhood Hits	228	Target Neighborhood Hits	493	Shared Neighborhood Hits	68
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

ABR_HUMAN
NC score	0.545812 (rank : 33)	θ value	8.38298e-14 (rank : 29)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

CHIN_MOUSE
NC score	0.538831 (rank : 34)	θ value	7.09661e-13 (rank : 41)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	65
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.537171 (rank : 35)	θ value	9.26847e-13 (rank : 44)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

BCR_HUMAN
NC score	0.535814 (rank : 36)	θ value	1.09485e-13 (rank : 30)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CHIO_HUMAN
NC score	0.535179 (rank : 37)	θ value	3.18553e-13 (rank : 33)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	64
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RBP1_HUMAN
NC score	0.532787 (rank : 38)	θ value	1.74796e-11 (rank : 53)
Query Neighborhood Hits	228	Target Neighborhood Hits	521	Shared Neighborhood Hits	68
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG01_HUMAN
NC score	0.529588 (rank : 39)	θ value	7.59969e-07 (rank : 79)
Query Neighborhood Hits	228	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

CENA2_HUMAN
NC score	0.529268 (rank : 40)	θ value	1.47974e-10 (rank : 59)
Query Neighborhood Hits	228	Target Neighborhood Hits	83	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

TAGAP_HUMAN
NC score	0.528746 (rank : 41)	θ value	5.81887e-07 (rank : 77)
Query Neighborhood Hits	228	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.524399 (rank : 42)	θ value	5.81887e-07 (rank : 78)
Query Neighborhood Hits	228	Target Neighborhood Hits	83	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG07_MOUSE
NC score	0.523691 (rank : 43)	θ value	4.91457e-14 (rank : 28)
Query Neighborhood Hits	228	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

CENA2_MOUSE
NC score	0.522451 (rank : 44)	θ value	2.13673e-09 (rank : 70)
Query Neighborhood Hits	228	Target Neighborhood Hits	68	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

RHG04_HUMAN
NC score	0.521227 (rank : 45)	θ value	5.08577e-11 (rank : 56)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	64
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG25_MOUSE
NC score	0.519417 (rank : 46)	θ value	4.0297e-08 (rank : 75)
Query Neighborhood Hits	228	Target Neighborhood Hits	492	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ARFG3_HUMAN
NC score	0.517919 (rank : 47)	θ value	9.59137e-10 (rank : 67)
Query Neighborhood Hits	228	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RHG07_HUMAN
NC score	0.517763 (rank : 48)	θ value	4.16044e-13 (rank : 39)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

ARFG3_MOUSE
NC score	0.517091 (rank : 49)	θ value	3.29651e-10 (rank : 64)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

TCGAP_HUMAN
NC score	0.513004 (rank : 50)	θ value	7.58209e-15 (rank : 24)
Query Neighborhood Hits	228	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

DDFL1_HUMAN
NC score	0.508239 (rank : 51)	θ value	2.7842e-17 (rank : 8)
Query Neighborhood Hits	228	Target Neighborhood Hits	353	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

SRGP2_HUMAN
NC score	0.503200 (rank : 52)	θ value	7.34386e-10 (rank : 66)
Query Neighborhood Hits	228	Target Neighborhood Hits	331	Shared Neighborhood Hits	65
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ARFG1_MOUSE
NC score	0.501444 (rank : 53)	θ value	1.29631e-06 (rank : 80)
Query Neighborhood Hits	228	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SRGP2_MOUSE
NC score	0.496526 (rank : 54)	θ value	2.13673e-09 (rank : 71)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	65
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RHG08_MOUSE
NC score	0.494323 (rank : 55)	θ value	0.00175202 (rank : 99)
Query Neighborhood Hits	228	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

FNBP2_HUMAN
NC score	0.494087 (rank : 56)	θ value	1.74796e-11 (rank : 52)
Query Neighborhood Hits	228	Target Neighborhood Hits	432	Shared Neighborhood Hits	70
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG08_HUMAN
NC score	0.491766 (rank : 57)	θ value	0.000786445 (rank : 94)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

SRGP1_HUMAN
NC score	0.490862 (rank : 58)	θ value	8.11959e-09 (rank : 74)
Query Neighborhood Hits	228	Target Neighborhood Hits	390	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ARFG1_HUMAN
NC score	0.488597 (rank : 59)	θ value	2.88788e-06 (rank : 81)
Query Neighborhood Hits	228	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

STA13_HUMAN
NC score	0.486887 (rank : 60)	θ value	2.52405e-10 (rank : 63)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

DDFL1_MOUSE
NC score	0.485639 (rank : 61)	θ value	1.38178e-16 (rank : 11)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	58
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

STA13_MOUSE
NC score	0.484667 (rank : 62)	θ value	1.47974e-10 (rank : 60)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CENG1_MOUSE
NC score	0.482021 (rank : 63)	θ value	5.25075e-16 (rank : 17)
Query Neighborhood Hits	228	Target Neighborhood Hits	531	Shared Neighborhood Hits	63
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

RHG25_HUMAN
NC score	0.479564 (rank : 64)	θ value	6.87365e-08 (rank : 76)
Query Neighborhood Hits	228	Target Neighborhood Hits	550	Shared Neighborhood Hits	96
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CENB5_HUMAN
NC score	0.479010 (rank : 65)	θ value	7.58209e-15 (rank : 22)
Query Neighborhood Hits	228	Target Neighborhood Hits	395	Shared Neighborhood Hits	70
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB1_HUMAN
NC score	0.478589 (rank : 66)	θ value	4.91457e-14 (rank : 27)
Query Neighborhood Hits	228	Target Neighborhood Hits	383	Shared Neighborhood Hits	72
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENG1_HUMAN
NC score	0.477039 (rank : 67)	θ value	5.25075e-16 (rank : 16)
Query Neighborhood Hits	228	Target Neighborhood Hits	544	Shared Neighborhood Hits	63
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

STAR8_MOUSE
NC score	0.476982 (rank : 68)	θ value	9.59137e-10 (rank : 68)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

DDEF1_MOUSE
NC score	0.476104 (rank : 69)	θ value	7.58209e-15 (rank : 23)
Query Neighborhood Hits	228	Target Neighborhood Hits	592	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CENB2_HUMAN
NC score	0.475939 (rank : 70)	θ value	5.25075e-16 (rank : 15)
Query Neighborhood Hits	228	Target Neighborhood Hits	425	Shared Neighborhood Hits	75
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

STAR8_HUMAN
NC score	0.474670 (rank : 71)	θ value	1.25267e-09 (rank : 69)
Query Neighborhood Hits	228	Target Neighborhood Hits	216	Shared Neighborhood Hits	65
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

DDEF2_HUMAN
NC score	0.469856 (rank : 72)	θ value	4.44505e-15 (rank : 20)
Query Neighborhood Hits	228	Target Neighborhood Hits	599	Shared Neighborhood Hits	72
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CENG3_MOUSE
NC score	0.467325 (rank : 73)	θ value	4.29542e-18 (rank : 7)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.467062 (rank : 74)	θ value	1.92812e-18 (rank : 6)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DDEF2_MOUSE
NC score	0.465311 (rank : 75)	θ value	1.68911e-14 (rank : 26)
Query Neighborhood Hits	228	Target Neighborhood Hits	625	Shared Neighborhood Hits	73
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CENG2_MOUSE
NC score	0.446498 (rank : 76)	θ value	3.07829e-16 (rank : 13)
Query Neighborhood Hits	228	Target Neighborhood Hits	463	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
NC score	0.444266 (rank : 77)	θ value	1.80466e-16 (rank : 12)
Query Neighborhood Hits	228	Target Neighborhood Hits	471	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT2_MOUSE
NC score	0.436736 (rank : 78)	θ value	6.00763e-12 (rank : 49)
Query Neighborhood Hits	228	Target Neighborhood Hits	323	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_HUMAN
NC score	0.436522 (rank : 79)	θ value	2.28291e-11 (rank : 54)
Query Neighborhood Hits	228	Target Neighborhood Hits	381	Shared Neighborhood Hits	49
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

CE005_HUMAN
NC score	0.431988 (rank : 80)	θ value	0.000158464 (rank : 85)
Query Neighborhood Hits	228	Target Neighborhood Hits	213	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.427712 (rank : 81)	θ value	0.000461057 (rank : 90)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

GIT1_HUMAN
NC score	0.424091 (rank : 82)	θ value	2.52405e-10 (rank : 61)
Query Neighborhood Hits	228	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.422639 (rank : 83)	θ value	2.52405e-10 (rank : 62)
Query Neighborhood Hits	228	Target Neighborhood Hits	341	Shared Neighborhood Hits	44
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

NUPL_HUMAN
NC score	0.372094 (rank : 84)	θ value	9.29e-05 (rank : 83)
Query Neighborhood Hits	228	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
NC score	0.369220 (rank : 85)	θ value	9.29e-05 (rank : 84)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

HRBL_HUMAN
NC score	0.328998 (rank : 86)	θ value	0.00020696 (rank : 86)
Query Neighborhood Hits	228	Target Neighborhood Hits	179	Shared Neighborhood Hits	43
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

MYO9B_MOUSE
NC score	0.328412 (rank : 87)	θ value	2.7842e-17 (rank : 10)
Query Neighborhood Hits	228	Target Neighborhood Hits	311	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.326012 (rank : 88)	θ value	2.7842e-17 (rank : 9)
Query Neighborhood Hits	228	Target Neighborhood Hits	641	Shared Neighborhood Hits	78
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

HRBL_MOUSE
NC score	0.314588 (rank : 89)	θ value	0.00020696 (rank : 87)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	43
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

K1688_MOUSE
NC score	0.306359 (rank : 90)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	228	Target Neighborhood Hits	188	Shared Neighborhood Hits	68
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.297126 (rank : 91)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	228	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

P85A_HUMAN
NC score	0.281422 (rank : 92)	θ value	0.000270298 (rank : 89)
Query Neighborhood Hits	228	Target Neighborhood Hits	479	Shared Neighborhood Hits	62
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.275815 (rank : 93)	θ value	0.000461057 (rank : 91)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	63
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PKHA1_HUMAN
NC score	0.223200 (rank : 94)	θ value	7.1131e-05 (rank : 82)
Query Neighborhood Hits	228	Target Neighborhood Hits	127	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.216023 (rank : 95)	θ value	0.00102713 (rank : 96)
Query Neighborhood Hits	228	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
NC score	0.183719 (rank : 96)	θ value	0.00298849 (rank : 103)
Query Neighborhood Hits	228	Target Neighborhood Hits	116	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

OCRL_HUMAN
NC score	0.174855 (rank : 97)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	228	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
NC score	0.172722 (rank : 98)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	228	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

PKHA2_HUMAN
NC score	0.160173 (rank : 99)	θ value	0.125558 (rank : 129)
Query Neighborhood Hits	228	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA6_MOUSE
NC score	0.155377 (rank : 100)	θ value	0.0961366 (rank : 125)
Query Neighborhood Hits	228	Target Neighborhood Hits	591	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
NC score	0.151640 (rank : 101)	θ value	0.21417 (rank : 137)
Query Neighborhood Hits	228	Target Neighborhood Hits	556	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DGKH_HUMAN
NC score	0.135747 (rank : 102)	θ value	0.000270298 (rank : 88)
Query Neighborhood Hits	228	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKD_HUMAN
NC score	0.120035 (rank : 103)	θ value	0.00228821 (rank : 100)
Query Neighborhood Hits	228	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PKHA4_MOUSE
NC score	0.104568 (rank : 104)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	228	Target Neighborhood Hits	202	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CSKI2_MOUSE
NC score	0.100515 (rank : 105)	θ value	0.0961366 (rank : 123)
Query Neighborhood Hits	228	Target Neighborhood Hits	812	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_HUMAN
NC score	0.100377 (rank : 106)	θ value	0.125558 (rank : 126)
Query Neighborhood Hits	228	Target Neighborhood Hits	747	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI1_HUMAN
NC score	0.098225 (rank : 107)	θ value	0.0431538 (rank : 114)
Query Neighborhood Hits	228	Target Neighborhood Hits	997	Shared Neighborhood Hits	103
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

PKHA4_HUMAN
NC score	0.096004 (rank : 108)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	228	Target Neighborhood Hits	283	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CSKI1_MOUSE
NC score	0.095244 (rank : 109)	θ value	0.0431538 (rank : 115)
Query Neighborhood Hits	228	Target Neighborhood Hits	1031	Shared Neighborhood Hits	96
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DP13A_HUMAN
NC score	0.094995 (rank : 110)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	228	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
NC score	0.092285 (rank : 111)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	228	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DAPP1_MOUSE
NC score	0.091645 (rank : 112)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DP13B_MOUSE
NC score	0.090268 (rank : 113)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	228	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DAPP1_HUMAN
NC score	0.089643 (rank : 114)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA5_HUMAN
NC score	0.087279 (rank : 115)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CYH1_MOUSE
NC score	0.084639 (rank : 116)	θ value	0.47712 (rank : 143)
Query Neighborhood Hits	228	Target Neighborhood Hits	176	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DP13B_HUMAN
NC score	0.084494 (rank : 117)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	228	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CYH1_HUMAN
NC score	0.083728 (rank : 118)	θ value	0.47712 (rank : 142)
Query Neighborhood Hits	228	Target Neighborhood Hits	184	Shared Neighborhood Hits	40
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH2_HUMAN
NC score	0.080633 (rank : 119)	θ value	0.47712 (rank : 144)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.080516 (rank : 120)	θ value	0.47712 (rank : 145)
Query Neighborhood Hits	228	Target Neighborhood Hits	171	Shared Neighborhood Hits	41
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

TNKS1_HUMAN
NC score	0.080473 (rank : 121)	θ value	0.00869519 (rank : 107)
Query Neighborhood Hits	228	Target Neighborhood Hits	477	Shared Neighborhood Hits	58
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

CT086_HUMAN
NC score	0.080000 (rank : 122)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	228	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

EPHB6_HUMAN
NC score	0.079383 (rank : 123)	θ value	0.000786445 (rank : 93)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	45
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

CYH3_HUMAN
NC score	0.078575 (rank : 124)	θ value	0.47712 (rank : 146)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

EPHB6_MOUSE
NC score	0.078470 (rank : 125)	θ value	0.000602161 (rank : 92)
Query Neighborhood Hits	228	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

3BP2_HUMAN
NC score	0.076596 (rank : 126)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	228	Target Neighborhood Hits	296	Shared Neighborhood Hits	50
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PLEK_HUMAN
NC score	0.074690 (rank : 127)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	228	Target Neighborhood Hits	110	Shared Neighborhood Hits	40
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CNKR1_HUMAN
NC score	0.073885 (rank : 128)	θ value	1.06291 (rank : 158)
Query Neighborhood Hits	228	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

MYO10_HUMAN
NC score	0.073364 (rank : 129)	θ value	0.163984 (rank : 133)
Query Neighborhood Hits	228	Target Neighborhood Hits	920	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TNKS2_HUMAN
NC score	0.072586 (rank : 130)	θ value	0.0431538 (rank : 117)
Query Neighborhood Hits	228	Target Neighborhood Hits	361	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

CYH3_MOUSE
NC score	0.071474 (rank : 131)	θ value	1.81305 (rank : 162)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

EPHA6_HUMAN
NC score	0.070559 (rank : 132)	θ value	0.163984 (rank : 130)
Query Neighborhood Hits	228	Target Neighborhood Hits	959	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA4_HUMAN
NC score	0.069439 (rank : 133)	θ value	0.00102713 (rank : 95)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	43
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA1_MOUSE
NC score	0.068786 (rank : 134)	θ value	0.00509761 (rank : 104)
Query Neighborhood Hits	228	Target Neighborhood Hits	958	Shared Neighborhood Hits	43
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

GAB2_MOUSE
NC score	0.068562 (rank : 135)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

ANR37_MOUSE
NC score	0.068487 (rank : 136)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

EPHA6_MOUSE
NC score	0.068365 (rank : 137)	θ value	0.279714 (rank : 138)
Query Neighborhood Hits	228	Target Neighborhood Hits	946	Shared Neighborhood Hits	44
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA8_MOUSE
NC score	0.068262 (rank : 138)	θ value	0.00175202 (rank : 98)
Query Neighborhood Hits	228	Target Neighborhood Hits	969	Shared Neighborhood Hits	44
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA4_MOUSE
NC score	0.068117 (rank : 139)	θ value	0.00175202 (rank : 97)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

ANR41_HUMAN
NC score	0.068011 (rank : 140)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

HSF1_MOUSE
NC score	0.067230 (rank : 141)	θ value	0.00509761 (rank : 105)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	19
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

EPHA1_HUMAN
NC score	0.066704 (rank : 142)	θ value	0.0193708 (rank : 109)
Query Neighborhood Hits	228	Target Neighborhood Hits	997	Shared Neighborhood Hits	41
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA8_HUMAN
NC score	0.066119 (rank : 143)	θ value	0.00869519 (rank : 106)
Query Neighborhood Hits	228	Target Neighborhood Hits	956	Shared Neighborhood Hits	43
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHAA_HUMAN
NC score	0.065956 (rank : 144)	θ value	0.813845 (rank : 153)
Query Neighborhood Hits	228	Target Neighborhood Hits	960	Shared Neighborhood Hits	42
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHA5_HUMAN
NC score	0.065952 (rank : 145)	θ value	0.00298849 (rank : 102)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	48
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

3BP2_MOUSE
NC score	0.065142 (rank : 146)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	228	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

GAB2_HUMAN
NC score	0.064812 (rank : 147)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	228	Target Neighborhood Hits	188	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

EPHA7_HUMAN
NC score	0.064803 (rank : 148)	θ value	0.0330416 (rank : 113)
Query Neighborhood Hits	228	Target Neighborhood Hits	1053	Shared Neighborhood Hits	47
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHB2_HUMAN
NC score	0.064325 (rank : 149)	θ value	0.0736092 (rank : 120)
Query Neighborhood Hits	228	Target Neighborhood Hits	983	Shared Neighborhood Hits	44
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA7_MOUSE
NC score	0.064007 (rank : 150)	θ value	0.0736092 (rank : 119)
Query Neighborhood Hits	228	Target Neighborhood Hits	1025	Shared Neighborhood Hits	44
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB1_HUMAN
NC score	0.063899 (rank : 151)	θ value	0.0148317 (rank : 108)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

ANR46_HUMAN
NC score	0.063891 (rank : 152)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

EPHB2_MOUSE
NC score	0.063824 (rank : 153)	θ value	0.0736092 (rank : 121)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

ANR46_MOUSE
NC score	0.063301 (rank : 154)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	228	Target Neighborhood Hits	274	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

EPHA2_MOUSE
NC score	0.063230 (rank : 155)	θ value	0.0961366 (rank : 124)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	44
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

P85B_HUMAN
NC score	0.063143 (rank : 156)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CYH4_MOUSE
NC score	0.062885 (rank : 157)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

EPHB3_HUMAN
NC score	0.062808 (rank : 158)	θ value	0.279714 (rank : 139)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	45
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA2_HUMAN
NC score	0.062643 (rank : 159)	θ value	0.21417 (rank : 136)
Query Neighborhood Hits	228	Target Neighborhood Hits	1021	Shared Neighborhood Hits	44
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ANR39_MOUSE
NC score	0.062607 (rank : 160)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

SASH1_HUMAN
NC score	0.062469 (rank : 161)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

CYH4_HUMAN
NC score	0.062210 (rank : 162)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	228	Target Neighborhood Hits	135	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

EPHB3_MOUSE
NC score	0.061842 (rank : 163)	θ value	0.365318 (rank : 140)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	43
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

ANR39_HUMAN
NC score	0.061715 (rank : 164)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

IKBB_MOUSE
NC score	0.060911 (rank : 165)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

EPHB4_MOUSE
NC score	0.060547 (rank : 166)	θ value	0.125558 (rank : 127)
Query Neighborhood Hits	228	Target Neighborhood Hits	1013	Shared Neighborhood Hits	45
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB4_HUMAN
NC score	0.060013 (rank : 167)	θ value	0.163984 (rank : 131)
Query Neighborhood Hits	228	Target Neighborhood Hits	1056	Shared Neighborhood Hits	45
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

PLEK2_HUMAN
NC score	0.059386 (rank : 168)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

SASH1_MOUSE
NC score	0.059264 (rank : 169)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	228	Target Neighborhood Hits	263	Shared Neighborhood Hits	51
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ANR37_HUMAN
NC score	0.059146 (rank : 170)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	228	Target Neighborhood Hits	247	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

PLEK_MOUSE
NC score	0.059127 (rank : 171)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	228	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

GABP3_MOUSE
NC score	0.058796 (rank : 172)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	228	Target Neighborhood Hits	330	Shared Neighborhood Hits	26
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

SHAN1_HUMAN
NC score	0.058368 (rank : 173)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	228	Target Neighborhood Hits	1041	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

DGKK_HUMAN
NC score	0.058145 (rank : 174)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	228	Target Neighborhood Hits	378	Shared Neighborhood Hits	46
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

IASPP_MOUSE
NC score	0.058094 (rank : 175)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	228	Target Neighborhood Hits	1024	Shared Neighborhood Hits	60
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANS4B_MOUSE
NC score	0.057834 (rank : 176)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	228	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

PLEK2_MOUSE
NC score	0.057455 (rank : 177)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	228	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

ANKS1_MOUSE
NC score	0.057283 (rank : 178)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	62
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

GABP2_HUMAN
NC score	0.056672 (rank : 179)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	228	Target Neighborhood Hits	454	Shared Neighborhood Hits	26
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
NC score	0.056577 (rank : 180)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	228	Target Neighborhood Hits	429	Shared Neighborhood Hits	27
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ILK2_HUMAN
NC score	0.056282 (rank : 181)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	228	Target Neighborhood Hits	848	Shared Neighborhood Hits	55
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

EPHA5_MOUSE
NC score	0.055558 (rank : 182)	θ value	0.0330416 (rank : 112)
Query Neighborhood Hits	228	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ILK1_HUMAN
NC score	0.055262 (rank : 183)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	228	Target Neighborhood Hits	857	Shared Neighborhood Hits	55
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

RAPH1_HUMAN
NC score	0.054688 (rank : 184)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	228	Target Neighborhood Hits	593	Shared Neighborhood Hits	53
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

GAB1_HUMAN
NC score	0.054614 (rank : 185)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	228	Target Neighborhood Hits	279	Shared Neighborhood Hits	31
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

ILK_MOUSE
NC score	0.054505 (rank : 186)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	228	Target Neighborhood Hits	858	Shared Neighborhood Hits	55
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ANS4B_HUMAN
NC score	0.053593 (rank : 187)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

IKBB_HUMAN
NC score	0.053497 (rank : 188)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

MTPN_MOUSE
NC score	0.053393 (rank : 189)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

CNKR2_MOUSE
NC score	0.053050 (rank : 190)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	228	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PCTL_MOUSE
NC score	0.052870 (rank : 191)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	228	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

EPHA3_MOUSE
NC score	0.052849 (rank : 192)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	37
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ANKS1_HUMAN
NC score	0.052766 (rank : 193)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	228	Target Neighborhood Hits	438	Shared Neighborhood Hits	61
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

CNKR2_HUMAN
NC score	0.052632 (rank : 194)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	228	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

IASPP_HUMAN
NC score	0.052319 (rank : 195)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	228	Target Neighborhood Hits	688	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PCTL_HUMAN
NC score	0.052259 (rank : 196)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	228	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

EPHA3_HUMAN
NC score	0.052194 (rank : 197)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	228	Target Neighborhood Hits	1005	Shared Neighborhood Hits	36
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

ANR42_HUMAN
NC score	0.052132 (rank : 198)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	228	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

GRP3_HUMAN
NC score	0.051892 (rank : 199)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

MTPN_HUMAN
NC score	0.051885 (rank : 200)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

CDN2D_HUMAN
NC score	0.051811 (rank : 201)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	228	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ANKR6_HUMAN
NC score	0.051795 (rank : 202)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	228	Target Neighborhood Hits	439	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ASB10_HUMAN
NC score	0.051605 (rank : 203)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	228	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANR10_HUMAN
NC score	0.051517 (rank : 204)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

HSF1_HUMAN
NC score	0.051503 (rank : 205)	θ value	0.0252991 (rank : 110)
Query Neighborhood Hits	228	Target Neighborhood Hits	163	Shared Neighborhood Hits	7
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

HECD1_HUMAN
NC score	0.051020 (rank : 206)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	228	Target Neighborhood Hits	371	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

ANKR2_HUMAN
NC score	0.050950 (rank : 207)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	228	Target Neighborhood Hits	321	Shared Neighborhood Hits	26
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

MYPT1_MOUSE
NC score	0.050855 (rank : 208)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	228	Target Neighborhood Hits	539	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

SHAN2_MOUSE
NC score	0.050588 (rank : 209)	θ value	0.813845 (rank : 156)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ANK1_MOUSE
NC score	0.050337 (rank : 210)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	228	Target Neighborhood Hits	430	Shared Neighborhood Hits	29
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

USH1G_MOUSE
NC score	0.050295 (rank : 211)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANK1_HUMAN
NC score	0.050127 (rank : 212)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	228	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

USH1G_HUMAN
NC score	0.050119 (rank : 213)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

FARP1_HUMAN
NC score	0.048905 (rank : 214)	θ value	0.163984 (rank : 132)
Query Neighborhood Hits	228	Target Neighborhood Hits	241	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

I20L2_HUMAN
NC score	0.047738 (rank : 215)	θ value	0.0563607 (rank : 118)
Query Neighborhood Hits	228	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H9L3, Q64KA2	Gene names	ISG20L2
Domain Architecture
Description	Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-).

MKL1_MOUSE
NC score	0.046802 (rank : 216)	θ value	0.0431538 (rank : 116)
Query Neighborhood Hits	228	Target Neighborhood Hits	667	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

SHAN2_HUMAN
NC score	0.045333 (rank : 217)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	228	Target Neighborhood Hits	346	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

MDC1_MOUSE
NC score	0.045068 (rank : 218)	θ value	0.0252991 (rank : 111)
Query Neighborhood Hits	228	Target Neighborhood Hits	998	Shared Neighborhood Hits	39
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MTMRD_HUMAN
NC score	0.044362 (rank : 219)	θ value	0.813845 (rank : 155)
Query Neighborhood Hits	228	Target Neighborhood Hits	135	Shared Neighborhood Hits	33
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

NCOA6_MOUSE
NC score	0.044017 (rank : 220)	θ value	0.62314 (rank : 150)
Query Neighborhood Hits	228	Target Neighborhood Hits	1076	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NCOA6_HUMAN
NC score	0.040814 (rank : 221)	θ value	0.47712 (rank : 147)
Query Neighborhood Hits	228	Target Neighborhood Hits	1202	Shared Neighborhood Hits	51
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

FARP2_HUMAN
NC score	0.040281 (rank : 222)	θ value	0.813845 (rank : 154)
Query Neighborhood Hits	228	Target Neighborhood Hits	240	Shared Neighborhood Hits	37
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

TULP4_HUMAN
NC score	0.038716 (rank : 223)	θ value	0.0736092 (rank : 122)
Query Neighborhood Hits	228	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

MDC1_HUMAN
NC score	0.037813 (rank : 224)	θ value	0.62314 (rank : 149)
Query Neighborhood Hits	228	Target Neighborhood Hits	1446	Shared Neighborhood Hits	55
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

FARP2_MOUSE
NC score	0.036976 (rank : 225)	θ value	1.38821 (rank : 161)
Query Neighborhood Hits	228	Target Neighborhood Hits	209	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SON_HUMAN
NC score	0.036447 (rank : 226)	θ value	0.163984 (rank : 134)
Query Neighborhood Hits	228	Target Neighborhood Hits	1568	Shared Neighborhood Hits	59
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MIB1_MOUSE
NC score	0.036420 (rank : 227)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	228	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

SYNG_MOUSE
NC score	0.036331 (rank : 228)	θ value	0.365318 (rank : 141)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

AATK_HUMAN
NC score	0.035327 (rank : 229)	θ value	0.00298849 (rank : 101)
Query Neighborhood Hits	228	Target Neighborhood Hits	1243	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

SRRM2_HUMAN
NC score	0.033050 (rank : 230)	θ value	0.813845 (rank : 157)
Query Neighborhood Hits	228	Target Neighborhood Hits	1296	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

RTP3_MOUSE
NC score	0.032228 (rank : 231)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	228	Target Neighborhood Hits	374	Shared Neighborhood Hits	28
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

FAK1_MOUSE
NC score	0.030587 (rank : 232)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	228	Target Neighborhood Hits	850	Shared Neighborhood Hits	30
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

CECR2_HUMAN
NC score	0.029834 (rank : 233)	θ value	0.21417 (rank : 135)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

PCLO_HUMAN
NC score	0.029663 (rank : 234)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	228	Target Neighborhood Hits	2046	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SNAG_MOUSE
NC score	0.027984 (rank : 235)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	228	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWZ7, Q3TPT4	Gene names	Napg, Snapg
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

JADE2_MOUSE
NC score	0.027787 (rank : 236)	θ value	0.125558 (rank : 128)
Query Neighborhood Hits	228	Target Neighborhood Hits	560	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

SNAG_HUMAN
NC score	0.024492 (rank : 237)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	228	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q99747, Q9BUV1	Gene names	NAPG, SNAPG
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

PLCG1_MOUSE
NC score	0.023521 (rank : 238)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	24
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SYNG_HUMAN
NC score	0.023394 (rank : 239)	θ value	3.0926 (rank : 179)
Query Neighborhood Hits	228	Target Neighborhood Hits	160	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

PLCG1_HUMAN
NC score	0.023004 (rank : 240)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SPR1B_MOUSE
NC score	0.022800 (rank : 241)	θ value	0.47712 (rank : 148)
Query Neighborhood Hits	228	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SAPS1_HUMAN
NC score	0.022484 (rank : 242)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	228	Target Neighborhood Hits	704	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

GRB7_HUMAN
NC score	0.022413 (rank : 243)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	18
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

CO039_MOUSE
NC score	0.022292 (rank : 244)	θ value	0.813845 (rank : 152)
Query Neighborhood Hits	228	Target Neighborhood Hits	445	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

FMN2_HUMAN
NC score	0.022283 (rank : 245)	θ value	1.81305 (rank : 163)
Query Neighborhood Hits	228	Target Neighborhood Hits	484	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

SSBP4_HUMAN
NC score	0.021132 (rank : 246)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	228	Target Neighborhood Hits	753	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

EPO_MOUSE
NC score	0.020136 (rank : 247)	θ value	2.36792 (rank : 166)
Query Neighborhood Hits	228	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P07321	Gene names	Epo
Domain Architecture
Description	Erythropoietin precursor.

K1802_HUMAN
NC score	0.020038 (rank : 248)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	228	Target Neighborhood Hits	1378	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

TESK2_HUMAN
NC score	0.018999 (rank : 249)	θ value	3.0926 (rank : 180)
Query Neighborhood Hits	228	Target Neighborhood Hits	851	Shared Neighborhood Hits	32
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

SPR1A_MOUSE
NC score	0.018350 (rank : 250)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	228	Target Neighborhood Hits	343	Shared Neighborhood Hits	18
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

INT1_HUMAN
NC score	0.017603 (rank : 251)	θ value	1.06291 (rank : 159)
Query Neighborhood Hits	228	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

PSL1_HUMAN
NC score	0.017551 (rank : 252)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	228	Target Neighborhood Hits	650	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

R3HD2_MOUSE
NC score	0.017276 (rank : 253)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	228	Target Neighborhood Hits	397	Shared Neighborhood Hits	17
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

ZN318_HUMAN
NC score	0.017158 (rank : 254)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	228	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

SEPT9_MOUSE
NC score	0.015588 (rank : 255)	θ value	0.62314 (rank : 151)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	15
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

TPO_MOUSE
NC score	0.015583 (rank : 256)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	228	Target Neighborhood Hits	258	Shared Neighborhood Hits	16
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

MLL3_MOUSE
NC score	0.014623 (rank : 257)	θ value	2.36792 (rank : 167)
Query Neighborhood Hits	228	Target Neighborhood Hits	1399	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SVIL_MOUSE
NC score	0.014341 (rank : 258)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	228	Target Neighborhood Hits	439	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

PKHF1_MOUSE
NC score	0.013542 (rank : 259)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

IRF3_HUMAN
NC score	0.013446 (rank : 260)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	228	Target Neighborhood Hits	129	Shared Neighborhood Hits	8
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

TXLNB_HUMAN
NC score	0.012553 (rank : 261)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

JIP3_HUMAN
NC score	0.011839 (rank : 262)	θ value	1.81305 (rank : 164)
Query Neighborhood Hits	228	Target Neighborhood Hits	1039	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

MAP1A_HUMAN
NC score	0.011409 (rank : 263)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	228	Target Neighborhood Hits	1626	Shared Neighborhood Hits	46
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

CBL_HUMAN
NC score	0.011010 (rank : 264)	θ value	1.38821 (rank : 160)
Query Neighborhood Hits	228	Target Neighborhood Hits	353	Shared Neighborhood Hits	16
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

STAU2_HUMAN
NC score	0.010900 (rank : 265)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	228	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NUL3, Q6AHY7, Q96HM0, Q96HM1, Q9NVI5, Q9UGG6	Gene names	STAU2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

STAU2_MOUSE
NC score	0.010837 (rank : 266)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	228	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CJ67, Q8BSY8, Q8CJ66, Q8R175, Q91Z19, Q9D5N7	Gene names	Stau2
Domain Architecture	No domain graphic available
Description	Double-stranded RNA-binding protein Staufen homolog 2.

TF3C2_HUMAN
NC score	0.010205 (rank : 267)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	228	Target Neighborhood Hits	168	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

NEK1_MOUSE
NC score	0.010049 (rank : 268)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	228	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PKDRE_HUMAN
NC score	0.009709 (rank : 269)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	228	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

MYLK_MOUSE
NC score	0.009623 (rank : 270)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	228	Target Neighborhood Hits	1489	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

CN044_HUMAN
NC score	0.008149 (rank : 271)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MY7	Gene names	C14orf44
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf44.

JHD3C_HUMAN
NC score	0.006719 (rank : 272)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	228	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H3R0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3	Gene names	JMJD2C, GASC1, JHDM3C, KIAA0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein).

OPA1_HUMAN
NC score	0.006274 (rank : 273)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

FBX34_MOUSE
NC score	0.006229 (rank : 274)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	228	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

CENPF_HUMAN
NC score	0.005628 (rank : 275)	θ value	5.27518 (rank : 191)
Query Neighborhood Hits	228	Target Neighborhood Hits	1932	Shared Neighborhood Hits	40
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

WDR22_HUMAN
NC score	0.005169 (rank : 276)	θ value	2.36792 (rank : 169)
Query Neighborhood Hits	228	Target Neighborhood Hits	328	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

SEZ6L_HUMAN
NC score	0.003654 (rank : 277)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

ABCA5_MOUSE
NC score	0.003103 (rank : 278)	θ value	5.27518 (rank : 190)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K448, Q3TE17, Q3UUB4, Q6P1Y0, Q6ZPG4, Q810C7, Q8BM46, Q8BXG7	Gene names	Abca5, Kiaa1888
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 5.

UBP44_HUMAN
NC score	0.002651 (rank : 279)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	228	Target Neighborhood Hits	91	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0E7	Gene names	USP44
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.1.2.15) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) (Deubiquitinating enzyme 44).

SPA11_HUMAN
NC score	0.001365 (rank : 280)	θ value	2.36792 (rank : 168)
Query Neighborhood Hits	228	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q86U17	Gene names	SERPINA11
Domain Architecture	No domain graphic available
Description	Serpin A11 precursor.

GOGA6_HUMAN
NC score	0.001320 (rank : 281)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	228	Target Neighborhood Hits	1007	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

KCNB2_HUMAN
NC score	-0.000171 (rank : 282)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	228	Target Neighborhood Hits	212	Shared Neighborhood Hits	7
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

CADH2_HUMAN
NC score	-0.000958 (rank : 283)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	228	Target Neighborhood Hits	161	Shared Neighborhood Hits	2
SwissProt Accessions	P19022, Q14923	Gene names	CDH2, CDHN, NCAD
Domain Architecture
Description	Cadherin-2 precursor (Neural-cadherin) (N-cadherin) (CDw325 antigen).

SP6_HUMAN
NC score	-0.006126 (rank : 284)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	228	Target Neighborhood Hits	700	Shared Neighborhood Hits	5
SwissProt Accessions	Q3SY56	Gene names	SP6, KLF14
Domain Architecture	No domain graphic available
Description	Transcription factor Sp6 (Krueppel-like factor 14).

SALL1_HUMAN
NC score	-0.006217 (rank : 285)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	228	Target Neighborhood Hits	821	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

SP6_MOUSE
NC score	-0.006320 (rank : 286)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	228	Target Neighborhood Hits	704	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESX2, Q6VM22	Gene names	Sp6, Epfn, Klf14
Domain Architecture	No domain graphic available
Description	Transcription factor Sp6 (Krueppel-like factor 14) (Epiprofin).

ZN236_HUMAN
NC score	-0.007024 (rank : 287)	θ value	3.0926 (rank : 181)
Query Neighborhood Hits	228	Target Neighborhood Hits	844	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UL36, Q9UL37	Gene names	ZNF236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 236.