Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PKDRE_HUMAN

For an explanation of this page, click here

PKDRE_HUMAN
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKDRE_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	64	Target Neighborhood Hits	64	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	0 (rank : 2)	NC score	0.984787 (rank : 2)
Query Neighborhood Hits	64	Target Neighborhood Hits	76	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
θ value	1.28732e-30 (rank : 3)	NC score	0.604179 (rank : 5)
Query Neighborhood Hits	64	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PK2L1_HUMAN
θ value	2.12685e-25 (rank : 4)	NC score	0.601621 (rank : 6)
Query Neighborhood Hits	64	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_MOUSE
θ value	1.80048e-24 (rank : 5)	NC score	0.607761 (rank : 3)
Query Neighborhood Hits	64	Target Neighborhood Hits	99	Shared Neighborhood Hits	34
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
θ value	1.5242e-23 (rank : 6)	NC score	0.600242 (rank : 7)
Query Neighborhood Hits	64	Target Neighborhood Hits	105	Shared Neighborhood Hits	33
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L2_MOUSE
θ value	9.24701e-21 (rank : 7)	NC score	0.604381 (rank : 4)
Query Neighborhood Hits	64	Target Neighborhood Hits	84	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_HUMAN
θ value	2.5182e-18 (rank : 8)	NC score	0.587415 (rank : 8)
Query Neighborhood Hits	64	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD1_HUMAN
θ value	1.63225e-17 (rank : 9)	NC score	0.325663 (rank : 13)
Query Neighborhood Hits	64	Target Neighborhood Hits	387	Shared Neighborhood Hits	16
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

LOX5_HUMAN
θ value	1.47974e-10 (rank : 10)	NC score	0.189461 (rank : 16)
Query Neighborhood Hits	64	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P09917	Gene names	ALOX5, LOG5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

LOX5_MOUSE
θ value	6.21693e-09 (rank : 11)	NC score	0.178279 (rank : 17)
Query Neighborhood Hits	64	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P48999	Gene names	Alox5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

MCLN1_HUMAN
θ value	1.17247e-07 (rank : 12)	NC score	0.337938 (rank : 9)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

MCLN1_MOUSE
θ value	1.99992e-07 (rank : 13)	NC score	0.331424 (rank : 11)
Query Neighborhood Hits	64	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

MCLN3_HUMAN
θ value	4.45536e-07 (rank : 14)	NC score	0.333927 (rank : 10)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN3_MOUSE
θ value	9.92553e-07 (rank : 15)	NC score	0.329507 (rank : 12)
Query Neighborhood Hits	64	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN2_HUMAN
θ value	0.00020696 (rank : 16)	NC score	0.316608 (rank : 14)
Query Neighborhood Hits	64	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN2_MOUSE
θ value	0.000461057 (rank : 17)	NC score	0.309969 (rank : 15)
Query Neighborhood Hits	64	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

SCN5A_HUMAN
θ value	0.000602161 (rank : 18)	NC score	0.148035 (rank : 18)
Query Neighborhood Hits	64	Target Neighborhood Hits	145	Shared Neighborhood Hits	26
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SC11A_MOUSE
θ value	0.00390308 (rank : 19)	NC score	0.125784 (rank : 22)
Query Neighborhood Hits	64	Target Neighborhood Hits	116	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC10A_HUMAN
θ value	0.0252991 (rank : 20)	NC score	0.132002 (rank : 19)
Query Neighborhood Hits	64	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

RA6I1_HUMAN
θ value	0.0736092 (rank : 21)	NC score	0.097460 (rank : 42)
Query Neighborhood Hits	64	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

RA6I1_MOUSE
θ value	0.125558 (rank : 22)	NC score	0.093160 (rank : 46)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

CAC1C_MOUSE
θ value	0.163984 (rank : 23)	NC score	0.107530 (rank : 32)
Query Neighborhood Hits	64	Target Neighborhood Hits	130	Shared Neighborhood Hits	25
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

SC10A_MOUSE
θ value	0.163984 (rank : 24)	NC score	0.125789 (rank : 21)
Query Neighborhood Hits	64	Target Neighborhood Hits	107	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

HPS6_HUMAN
θ value	0.21417 (rank : 25)	NC score	0.046115 (rank : 62)
Query Neighborhood Hits	64	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YV9, Q9H685	Gene names	HPS6
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 6 protein (Ruby-eye protein homolog) (Ru).

SCN1A_HUMAN
θ value	0.279714 (rank : 26)	NC score	0.119512 (rank : 23)
Query Neighborhood Hits	64	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0.279714 (rank : 27)	NC score	0.119034 (rank : 24)
Query Neighborhood Hits	64	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

TXND2_MOUSE
θ value	0.279714 (rank : 28)	NC score	0.020234 (rank : 69)
Query Neighborhood Hits	64	Target Neighborhood Hits	828	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

CAC1G_HUMAN
θ value	0.365318 (rank : 29)	NC score	0.101955 (rank : 36)
Query Neighborhood Hits	64	Target Neighborhood Hits	587	Shared Neighborhood Hits	29
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

LIPE_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.046177 (rank : 61)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5X9, Q6UW82	Gene names	LIPG
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL).

LX12B_HUMAN
θ value	0.365318 (rank : 31)	NC score	0.109577 (rank : 30)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	O75342	Gene names	ALOX12B
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX).

SCN3A_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.118674 (rank : 25)
Query Neighborhood Hits	64	Target Neighborhood Hits	115	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SC11A_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.127851 (rank : 20)
Query Neighborhood Hits	64	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

CAC1F_MOUSE
θ value	0.813845 (rank : 34)	NC score	0.107784 (rank : 31)
Query Neighborhood Hits	64	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

SNX10_HUMAN
θ value	0.813845 (rank : 35)	NC score	0.041957 (rank : 64)
Query Neighborhood Hits	64	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5X0	Gene names	SNX10
Domain Architecture
Description	Sorting nexin-10.

SNX10_MOUSE
θ value	0.813845 (rank : 36)	NC score	0.041871 (rank : 65)
Query Neighborhood Hits	64	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWT3, Q8C1E0	Gene names	Snx10
Domain Architecture	No domain graphic available
Description	Sorting nexin-10.

LX12B_MOUSE
θ value	1.06291 (rank : 37)	NC score	0.102062 (rank : 35)
Query Neighborhood Hits	64	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	O70582	Gene names	Alox12b, Aloxe2
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX) (Epidermis-type lipoxygenase 2) (e-LOX 2).

LIPE_MOUSE
θ value	1.38821 (rank : 38)	NC score	0.044901 (rank : 63)
Query Neighborhood Hits	64	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVG5, Q8VDU2	Gene names	Lipg
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL).

SCN8A_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.111722 (rank : 29)
Query Neighborhood Hits	64	Target Neighborhood Hits	135	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	1.38821 (rank : 40)	NC score	0.111879 (rank : 28)
Query Neighborhood Hits	64	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1H_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.090949 (rank : 48)
Query Neighborhood Hits	64	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

DEK_HUMAN
θ value	1.81305 (rank : 42)	NC score	0.031667 (rank : 66)
Query Neighborhood Hits	64	Target Neighborhood Hits	199	Shared Neighborhood Hits	3
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

LAMA1_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.006363 (rank : 77)
Query Neighborhood Hits	64	Target Neighborhood Hits	804	Shared Neighborhood Hits	3
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LOXE3_MOUSE
θ value	1.81305 (rank : 44)	NC score	0.090142 (rank : 49)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WV07	Gene names	Aloxe3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

SCN4A_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.113899 (rank : 27)
Query Neighborhood Hits	64	Target Neighborhood Hits	133	Shared Neighborhood Hits	26
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

LRC27_MOUSE
θ value	2.36792 (rank : 46)	NC score	0.021454 (rank : 68)
Query Neighborhood Hits	64	Target Neighborhood Hits	290	Shared Neighborhood Hits	4
SwissProt Accessions	Q80YS5, Q9D6Z2	Gene names	Lrrc27
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

TRY3_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.003657 (rank : 82)
Query Neighborhood Hits	64	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

O12D2_HUMAN
θ value	3.0926 (rank : 48)	NC score	-0.000858 (rank : 83)
Query Neighborhood Hits	64	Target Neighborhood Hits	682	Shared Neighborhood Hits	2
SwissProt Accessions	P58182	Gene names	OR12D2
Domain Architecture
Description	Olfactory receptor 12D2 (Hs6M1-20).

SCN9A_HUMAN
θ value	3.0926 (rank : 49)	NC score	0.118177 (rank : 26)
Query Neighborhood Hits	64	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

AFAD_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.010332 (rank : 74)
Query Neighborhood Hits	64	Target Neighborhood Hits	689	Shared Neighborhood Hits	4
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

ARY3_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.016843 (rank : 70)
Query Neighborhood Hits	64	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P50296	Gene names	Nat3, Aac3
Domain Architecture
Description	Arylamine N-acetyltransferase 3 (EC 2.3.1.5) (Arylamide acetylase 3) (N-acetyltransferase type 3) (NAT-3).

CEND3_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.024195 (rank : 67)
Query Neighborhood Hits	64	Target Neighborhood Hits	275	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

HB2P_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.004764 (rank : 78)
Query Neighborhood Hits	64	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	P04440, O19698, O19700, O19702	Gene names	HLA-DPB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W4) beta chain precursor.

HB2Q_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.004705 (rank : 80)
Query Neighborhood Hits	64	Target Neighborhood Hits	212	Shared Neighborhood Hits	3
SwissProt Accessions	P13763	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W2) beta chain precursor (SB-2-beta).

LRC8B_MOUSE
θ value	5.27518 (rank : 55)	NC score	0.004756 (rank : 79)
Query Neighborhood Hits	64	Target Neighborhood Hits	283	Shared Neighborhood Hits	3
SwissProt Accessions	Q5DU41	Gene names	Lrrc8b, Kiaa0231
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8B.

TCEA2_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.011417 (rank : 71)
Query Neighborhood Hits	64	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q15560, Q8TD37, Q8TD38	Gene names	TCEA2
Domain Architecture
Description	Transcription elongation factor A protein 2 (Transcription elongation factor S-II protein 2) (Testis-specific S-II) (Transcription elongation factor TFIIS.l).

ABCA4_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.004078 (rank : 81)
Query Neighborhood Hits	64	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P78363, O15112, O60438, O60915	Gene names	ABCA4, ABCR
Domain Architecture
Description	Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) (Stargardt disease protein).

CAC1C_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.101153 (rank : 37)
Query Neighborhood Hits	64	Target Neighborhood Hits	158	Shared Neighborhood Hits	25
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1E_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.107096 (rank : 34)
Query Neighborhood Hits	64	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.107262 (rank : 33)
Query Neighborhood Hits	64	Target Neighborhood Hits	167	Shared Neighborhood Hits	28
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CEND3_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.009709 (rank : 75)
Query Neighborhood Hits	64	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

GPR88_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.011177 (rank : 72)
Query Neighborhood Hits	64	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPB7	Gene names	Gpr88, Strg
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 88 (Striatum-specific G-protein coupled receptor).

ALMS1_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.008428 (rank : 76)
Query Neighborhood Hits	64	Target Neighborhood Hits	356	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

COG1_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.010963 (rank : 73)
Query Neighborhood Hits	64	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WTW3, Q9NPV9, Q9P2G6	Gene names	COG1, KIAA1381
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 1.

CAC1A_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.088986 (rank : 51)
Query Neighborhood Hits	64	Target Neighborhood Hits	387	Shared Neighborhood Hits	29
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.089350 (rank : 50)
Query Neighborhood Hits	64	Target Neighborhood Hits	267	Shared Neighborhood Hits	28
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.098972 (rank : 39)
Query Neighborhood Hits	64	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1B_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.094989 (rank : 44)
Query Neighborhood Hits	64	Target Neighborhood Hits	351	Shared Neighborhood Hits	30
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1D_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.097186 (rank : 43)
Query Neighborhood Hits	64	Target Neighborhood Hits	118	Shared Neighborhood Hits	25
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1F_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.100316 (rank : 38)
Query Neighborhood Hits	64	Target Neighborhood Hits	141	Shared Neighborhood Hits	24
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1H_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.083230 (rank : 52)
Query Neighborhood Hits	64	Target Neighborhood Hits	230	Shared Neighborhood Hits	25
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1I_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.098614 (rank : 40)
Query Neighborhood Hits	64	Target Neighborhood Hits	138	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1S_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.093217 (rank : 45)
Query Neighborhood Hits	64	Target Neighborhood Hits	92	Shared Neighborhood Hits	24
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.092659 (rank : 47)
Query Neighborhood Hits	64	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

LOX12_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.076807 (rank : 56)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P18054, O95569, Q6ISF8, Q9UQM4	Gene names	ALOX12, LOG12
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

LOX12_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.073961 (rank : 58)
Query Neighborhood Hits	64	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	P39655, Q8BHG4	Gene names	Alox12, Alox12p
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

LOX15_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.066564 (rank : 60)
Query Neighborhood Hits	64	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	P16050, Q8N6R7, Q99657	Gene names	ALOX15, LOG15
Domain Architecture
Description	Arachidonate 15-lipoxygenase (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (15-LOX).

LOXE3_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.082312 (rank : 53)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYJ1, Q9H4F2, Q9HC22	Gene names	ALOXE3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

LX12E_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.070990 (rank : 59)
Query Neighborhood Hits	64	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P55249, Q91YW6	Gene names	Alox12e, Alox12-ps2, Aloxe
Domain Architecture
Description	Arachidonate 12-lipoxygenase, epidermal-type (EC 1.13.11.31) (12-LOX).

LX12L_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.076560 (rank : 57)
Query Neighborhood Hits	64	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	P39654, Q4FJY9, Q5F2E3, Q6PHB2	Gene names	Alox12l, Alox15
Domain Architecture
Description	Arachidonate 12-lipoxygenase, leukocyte-type (EC 1.13.11.31) (12-LOX).

LX15B_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.077278 (rank : 55)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	7
SwissProt Accessions	O15296, Q8IYQ2, Q8TEV3, Q8TEV4, Q8TEV5, Q8TEV6, Q9UKM4	Gene names	ALOX15B
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (15- lipoxygenase 2).

LX15B_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.081033 (rank : 54)
Query Neighborhood Hits	64	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	O35936	Gene names	Alox15b, Alox8
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (8S- lipoxygenase) (8S-LOX).

SCN7A_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.097757 (rank : 41)
Query Neighborhood Hits	64	Target Neighborhood Hits	135	Shared Neighborhood Hits	23
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

Hits sorted by NC score

PKDRE_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	64	Target Neighborhood Hits	64	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
NC score	0.984787 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	64	Target Neighborhood Hits	76	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKD2_MOUSE
NC score	0.607761 (rank : 3)	θ value	1.80048e-24 (rank : 5)
Query Neighborhood Hits	64	Target Neighborhood Hits	99	Shared Neighborhood Hits	34
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L2_MOUSE
NC score	0.604381 (rank : 4)	θ value	9.24701e-21 (rank : 7)
Query Neighborhood Hits	64	Target Neighborhood Hits	84	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK1L1_HUMAN
NC score	0.604179 (rank : 5)	θ value	1.28732e-30 (rank : 3)
Query Neighborhood Hits	64	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PK2L1_HUMAN
NC score	0.601621 (rank : 6)	θ value	2.12685e-25 (rank : 4)
Query Neighborhood Hits	64	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_HUMAN
NC score	0.600242 (rank : 7)	θ value	1.5242e-23 (rank : 6)
Query Neighborhood Hits	64	Target Neighborhood Hits	105	Shared Neighborhood Hits	33
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L2_HUMAN
NC score	0.587415 (rank : 8)	θ value	2.5182e-18 (rank : 8)
Query Neighborhood Hits	64	Target Neighborhood Hits	90	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

MCLN1_HUMAN
NC score	0.337938 (rank : 9)	θ value	1.17247e-07 (rank : 12)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

MCLN3_HUMAN
NC score	0.333927 (rank : 10)	θ value	4.45536e-07 (rank : 14)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN1_MOUSE
NC score	0.331424 (rank : 11)	θ value	1.99992e-07 (rank : 13)
Query Neighborhood Hits	64	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

MCLN3_MOUSE
NC score	0.329507 (rank : 12)	θ value	9.92553e-07 (rank : 15)
Query Neighborhood Hits	64	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

PKD1_HUMAN
NC score	0.325663 (rank : 13)	θ value	1.63225e-17 (rank : 9)
Query Neighborhood Hits	64	Target Neighborhood Hits	387	Shared Neighborhood Hits	16
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

MCLN2_HUMAN
NC score	0.316608 (rank : 14)	θ value	0.00020696 (rank : 16)
Query Neighborhood Hits	64	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN2_MOUSE
NC score	0.309969 (rank : 15)	θ value	0.000461057 (rank : 17)
Query Neighborhood Hits	64	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

LOX5_HUMAN
NC score	0.189461 (rank : 16)	θ value	1.47974e-10 (rank : 10)
Query Neighborhood Hits	64	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P09917	Gene names	ALOX5, LOG5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

LOX5_MOUSE
NC score	0.178279 (rank : 17)	θ value	6.21693e-09 (rank : 11)
Query Neighborhood Hits	64	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P48999	Gene names	Alox5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

SCN5A_HUMAN
NC score	0.148035 (rank : 18)	θ value	0.000602161 (rank : 18)
Query Neighborhood Hits	64	Target Neighborhood Hits	145	Shared Neighborhood Hits	26
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SC10A_HUMAN
NC score	0.132002 (rank : 19)	θ value	0.0252991 (rank : 20)
Query Neighborhood Hits	64	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC11A_HUMAN
NC score	0.127851 (rank : 20)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	64	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC10A_MOUSE
NC score	0.125789 (rank : 21)	θ value	0.163984 (rank : 24)
Query Neighborhood Hits	64	Target Neighborhood Hits	107	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC11A_MOUSE
NC score	0.125784 (rank : 22)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	64	Target Neighborhood Hits	116	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
NC score	0.119512 (rank : 23)	θ value	0.279714 (rank : 26)
Query Neighborhood Hits	64	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
NC score	0.119034 (rank : 24)	θ value	0.279714 (rank : 27)
Query Neighborhood Hits	64	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
NC score	0.118674 (rank : 25)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	64	Target Neighborhood Hits	115	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN9A_HUMAN
NC score	0.118177 (rank : 26)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	64	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN4A_HUMAN
NC score	0.113899 (rank : 27)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	64	Target Neighborhood Hits	133	Shared Neighborhood Hits	26
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN8A_MOUSE
NC score	0.111879 (rank : 28)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	64	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_HUMAN
NC score	0.111722 (rank : 29)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	64	Target Neighborhood Hits	135	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

LX12B_HUMAN
NC score	0.109577 (rank : 30)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	64	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	O75342	Gene names	ALOX12B
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX).

CAC1F_MOUSE
NC score	0.107784 (rank : 31)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	64	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.107530 (rank : 32)	θ value	0.163984 (rank : 23)
Query Neighborhood Hits	64	Target Neighborhood Hits	130	Shared Neighborhood Hits	25
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1E_MOUSE
NC score	0.107262 (rank : 33)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	64	Target Neighborhood Hits	167	Shared Neighborhood Hits	28
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.107096 (rank : 34)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	64	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

LX12B_MOUSE
NC score	0.102062 (rank : 35)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	64	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	O70582	Gene names	Alox12b, Aloxe2
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX) (Epidermis-type lipoxygenase 2) (e-LOX 2).

CAC1G_HUMAN
NC score	0.101955 (rank : 36)	θ value	0.365318 (rank : 29)
Query Neighborhood Hits	64	Target Neighborhood Hits	587	Shared Neighborhood Hits	29
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1C_HUMAN
NC score	0.101153 (rank : 37)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	64	Target Neighborhood Hits	158	Shared Neighborhood Hits	25
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1F_HUMAN
NC score	0.100316 (rank : 38)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	64	Target Neighborhood Hits	141	Shared Neighborhood Hits	24
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1B_HUMAN
NC score	0.098972 (rank : 39)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	64	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1I_HUMAN
NC score	0.098614 (rank : 40)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	64	Target Neighborhood Hits	138	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SCN7A_HUMAN
NC score	0.097757 (rank : 41)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	64	Target Neighborhood Hits	135	Shared Neighborhood Hits	23
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

RA6I1_HUMAN
NC score	0.097460 (rank : 42)	θ value	0.0736092 (rank : 21)
Query Neighborhood Hits	64	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

CAC1D_HUMAN
NC score	0.097186 (rank : 43)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	64	Target Neighborhood Hits	118	Shared Neighborhood Hits	25
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1B_MOUSE
NC score	0.094989 (rank : 44)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	64	Target Neighborhood Hits	351	Shared Neighborhood Hits	30
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_HUMAN
NC score	0.093217 (rank : 45)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	64	Target Neighborhood Hits	92	Shared Neighborhood Hits	24
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

RA6I1_MOUSE
NC score	0.093160 (rank : 46)	θ value	0.125558 (rank : 22)
Query Neighborhood Hits	64	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

CAC1S_MOUSE
NC score	0.092659 (rank : 47)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	64	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1H_HUMAN
NC score	0.090949 (rank : 48)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	64	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

LOXE3_MOUSE
NC score	0.090142 (rank : 49)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WV07	Gene names	Aloxe3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

CAC1A_MOUSE
NC score	0.089350 (rank : 50)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	64	Target Neighborhood Hits	267	Shared Neighborhood Hits	28
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_HUMAN
NC score	0.088986 (rank : 51)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	64	Target Neighborhood Hits	387	Shared Neighborhood Hits	29
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1H_MOUSE
NC score	0.083230 (rank : 52)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	64	Target Neighborhood Hits	230	Shared Neighborhood Hits	25
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

LOXE3_HUMAN
NC score	0.082312 (rank : 53)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYJ1, Q9H4F2, Q9HC22	Gene names	ALOXE3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

LX15B_MOUSE
NC score	0.081033 (rank : 54)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	64	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	O35936	Gene names	Alox15b, Alox8
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (8S- lipoxygenase) (8S-LOX).

LX15B_HUMAN
NC score	0.077278 (rank : 55)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	7
SwissProt Accessions	O15296, Q8IYQ2, Q8TEV3, Q8TEV4, Q8TEV5, Q8TEV6, Q9UKM4	Gene names	ALOX15B
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (15- lipoxygenase 2).

LOX12_HUMAN
NC score	0.076807 (rank : 56)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	64	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P18054, O95569, Q6ISF8, Q9UQM4	Gene names	ALOX12, LOG12
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

LX12L_MOUSE
NC score	0.076560 (rank : 57)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	64	Target Neighborhood Hits	15	Shared Neighborhood Hits	7
SwissProt Accessions	P39654, Q4FJY9, Q5F2E3, Q6PHB2	Gene names	Alox12l, Alox15
Domain Architecture
Description	Arachidonate 12-lipoxygenase, leukocyte-type (EC 1.13.11.31) (12-LOX).

LOX12_MOUSE
NC score	0.073961 (rank : 58)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	64	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	P39655, Q8BHG4	Gene names	Alox12, Alox12p
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

LX12E_MOUSE
NC score	0.070990 (rank : 59)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	64	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P55249, Q91YW6	Gene names	Alox12e, Alox12-ps2, Aloxe
Domain Architecture
Description	Arachidonate 12-lipoxygenase, epidermal-type (EC 1.13.11.31) (12-LOX).

LOX15_HUMAN
NC score	0.066564 (rank : 60)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	64	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	P16050, Q8N6R7, Q99657	Gene names	ALOX15, LOG15
Domain Architecture
Description	Arachidonate 15-lipoxygenase (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (15-LOX).

LIPE_HUMAN
NC score	0.046177 (rank : 61)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	64	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5X9, Q6UW82	Gene names	LIPG
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL).

HPS6_HUMAN
NC score	0.046115 (rank : 62)	θ value	0.21417 (rank : 25)
Query Neighborhood Hits	64	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YV9, Q9H685	Gene names	HPS6
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 6 protein (Ruby-eye protein homolog) (Ru).

LIPE_MOUSE
NC score	0.044901 (rank : 63)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	64	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVG5, Q8VDU2	Gene names	Lipg
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL).

SNX10_HUMAN
NC score	0.041957 (rank : 64)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	64	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5X0	Gene names	SNX10
Domain Architecture
Description	Sorting nexin-10.

SNX10_MOUSE
NC score	0.041871 (rank : 65)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	64	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWT3, Q8C1E0	Gene names	Snx10
Domain Architecture	No domain graphic available
Description	Sorting nexin-10.

DEK_HUMAN
NC score	0.031667 (rank : 66)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	64	Target Neighborhood Hits	199	Shared Neighborhood Hits	3
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

CEND3_HUMAN
NC score	0.024195 (rank : 67)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	64	Target Neighborhood Hits	275	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

LRC27_MOUSE
NC score	0.021454 (rank : 68)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	64	Target Neighborhood Hits	290	Shared Neighborhood Hits	4
SwissProt Accessions	Q80YS5, Q9D6Z2	Gene names	Lrrc27
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

TXND2_MOUSE
NC score	0.020234 (rank : 69)	θ value	0.279714 (rank : 28)
Query Neighborhood Hits	64	Target Neighborhood Hits	828	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

ARY3_MOUSE
NC score	0.016843 (rank : 70)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	64	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P50296	Gene names	Nat3, Aac3
Domain Architecture
Description	Arylamine N-acetyltransferase 3 (EC 2.3.1.5) (Arylamide acetylase 3) (N-acetyltransferase type 3) (NAT-3).

TCEA2_HUMAN
NC score	0.011417 (rank : 71)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	64	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q15560, Q8TD37, Q8TD38	Gene names	TCEA2
Domain Architecture
Description	Transcription elongation factor A protein 2 (Transcription elongation factor S-II protein 2) (Testis-specific S-II) (Transcription elongation factor TFIIS.l).

GPR88_MOUSE
NC score	0.011177 (rank : 72)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	64	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPB7	Gene names	Gpr88, Strg
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 88 (Striatum-specific G-protein coupled receptor).

COG1_HUMAN
NC score	0.010963 (rank : 73)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	64	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WTW3, Q9NPV9, Q9P2G6	Gene names	COG1, KIAA1381
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 1.

AFAD_HUMAN
NC score	0.010332 (rank : 74)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	64	Target Neighborhood Hits	689	Shared Neighborhood Hits	4
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

CEND3_MOUSE
NC score	0.009709 (rank : 75)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	64	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

ALMS1_HUMAN
NC score	0.008428 (rank : 76)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	64	Target Neighborhood Hits	356	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

LAMA1_HUMAN
NC score	0.006363 (rank : 77)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	64	Target Neighborhood Hits	804	Shared Neighborhood Hits	3
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

HB2P_HUMAN
NC score	0.004764 (rank : 78)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	64	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	P04440, O19698, O19700, O19702	Gene names	HLA-DPB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W4) beta chain precursor.

LRC8B_MOUSE
NC score	0.004756 (rank : 79)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	64	Target Neighborhood Hits	283	Shared Neighborhood Hits	3
SwissProt Accessions	Q5DU41	Gene names	Lrrc8b, Kiaa0231
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8B.

HB2Q_HUMAN
NC score	0.004705 (rank : 80)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	64	Target Neighborhood Hits	212	Shared Neighborhood Hits	3
SwissProt Accessions	P13763	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W2) beta chain precursor (SB-2-beta).

ABCA4_HUMAN
NC score	0.004078 (rank : 81)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	64	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P78363, O15112, O60438, O60915	Gene names	ABCA4, ABCR
Domain Architecture
Description	Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) (Stargardt disease protein).

TRY3_HUMAN
NC score	0.003657 (rank : 82)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	64	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	P35030, P15951, Q15665, Q9UQV3	Gene names	PRSS3, PRSS4, TRY3, TRY4
Domain Architecture
Description	Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).

O12D2_HUMAN
NC score	-0.000858 (rank : 83)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	64	Target Neighborhood Hits	682	Shared Neighborhood Hits	2
SwissProt Accessions	P58182	Gene names	OR12D2
Domain Architecture
Description	Olfactory receptor 12D2 (Hs6M1-20).