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Network neighborhood for query Sequence : CAC1S_HUMAN

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CAC1S_HUMAN
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CAC1A_HUMAN
θ value	0 (rank : 1)	NC score	0.948006 (rank : 13)
Query Neighborhood Hits	92	Target Neighborhood Hits	387	Shared Neighborhood Hits	59
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_MOUSE
θ value	0 (rank : 2)	NC score	0.956604 (rank : 11)
Query Neighborhood Hits	92	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_HUMAN
θ value	0 (rank : 3)	NC score	0.957327 (rank : 10)
Query Neighborhood Hits	92	Target Neighborhood Hits	257	Shared Neighborhood Hits	58
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1B_MOUSE
θ value	0 (rank : 4)	NC score	0.952583 (rank : 12)
Query Neighborhood Hits	92	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_HUMAN
θ value	0 (rank : 5)	NC score	0.993726 (rank : 5)
Query Neighborhood Hits	92	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1C_MOUSE
θ value	0 (rank : 6)	NC score	0.994515 (rank : 4)
Query Neighborhood Hits	92	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1D_HUMAN
θ value	0 (rank : 7)	NC score	0.995599 (rank : 3)
Query Neighborhood Hits	92	Target Neighborhood Hits	118	Shared Neighborhood Hits	60
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1E_HUMAN
θ value	0 (rank : 8)	NC score	0.961510 (rank : 9)
Query Neighborhood Hits	92	Target Neighborhood Hits	148	Shared Neighborhood Hits	53
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	0 (rank : 9)	NC score	0.961648 (rank : 8)
Query Neighborhood Hits	92	Target Neighborhood Hits	167	Shared Neighborhood Hits	52
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1F_HUMAN
θ value	0 (rank : 10)	NC score	0.993545 (rank : 7)
Query Neighborhood Hits	92	Target Neighborhood Hits	141	Shared Neighborhood Hits	59
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_MOUSE
θ value	0 (rank : 11)	NC score	0.993549 (rank : 6)
Query Neighborhood Hits	92	Target Neighborhood Hits	142	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
θ value	0 (rank : 12)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
θ value	0 (rank : 13)	NC score	0.998457 (rank : 2)
Query Neighborhood Hits	92	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

SC11A_HUMAN
θ value	9.41505e-74 (rank : 14)	NC score	0.862934 (rank : 18)
Query Neighborhood Hits	92	Target Neighborhood Hits	111	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
θ value	8.81223e-72 (rank : 15)	NC score	0.864626 (rank : 17)
Query Neighborhood Hits	92	Target Neighborhood Hits	116	Shared Neighborhood Hits	60
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN2A_HUMAN
θ value	8.81223e-72 (rank : 16)	NC score	0.845884 (rank : 25)
Query Neighborhood Hits	92	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SC10A_MOUSE
θ value	1.50314e-71 (rank : 17)	NC score	0.847577 (rank : 24)
Query Neighborhood Hits	92	Target Neighborhood Hits	107	Shared Neighborhood Hits	57
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

CAC1I_HUMAN
θ value	1.96316e-71 (rank : 18)	NC score	0.900192 (rank : 14)
Query Neighborhood Hits	92	Target Neighborhood Hits	138	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SCN3A_HUMAN
θ value	1.27248e-70 (rank : 19)	NC score	0.848750 (rank : 23)
Query Neighborhood Hits	92	Target Neighborhood Hits	115	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN9A_HUMAN
θ value	3.13423e-69 (rank : 20)	NC score	0.845106 (rank : 27)
Query Neighborhood Hits	92	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN4A_HUMAN
θ value	1.19101e-68 (rank : 21)	NC score	0.855314 (rank : 21)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	61
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

CAC1H_HUMAN
θ value	5.91091e-68 (rank : 22)	NC score	0.872252 (rank : 16)
Query Neighborhood Hits	92	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

SC10A_HUMAN
θ value	5.91091e-68 (rank : 23)	NC score	0.842694 (rank : 29)
Query Neighborhood Hits	92	Target Neighborhood Hits	116	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

CAC1G_HUMAN
θ value	1.31681e-67 (rank : 24)	NC score	0.856547 (rank : 20)
Query Neighborhood Hits	92	Target Neighborhood Hits	587	Shared Neighborhood Hits	61
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN5A_HUMAN
θ value	2.93355e-67 (rank : 25)	NC score	0.857126 (rank : 19)
Query Neighborhood Hits	92	Target Neighborhood Hits	145	Shared Neighborhood Hits	56
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN1A_HUMAN
θ value	6.53529e-67 (rank : 26)	NC score	0.843179 (rank : 28)
Query Neighborhood Hits	92	Target Neighborhood Hits	148	Shared Neighborhood Hits	55
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN8A_HUMAN
θ value	8.53533e-67 (rank : 27)	NC score	0.845260 (rank : 26)
Query Neighborhood Hits	92	Target Neighborhood Hits	135	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	1.45591e-66 (rank : 28)	NC score	0.842680 (rank : 30)
Query Neighborhood Hits	92	Target Neighborhood Hits	136	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1H_MOUSE
θ value	2.4834e-66 (rank : 29)	NC score	0.875917 (rank : 15)
Query Neighborhood Hits	92	Target Neighborhood Hits	230	Shared Neighborhood Hits	64
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

SCN7A_HUMAN
θ value	2.18062e-54 (rank : 30)	NC score	0.855059 (rank : 22)
Query Neighborhood Hits	92	Target Neighborhood Hits	135	Shared Neighborhood Hits	53
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

PK2L1_HUMAN
θ value	4.92598e-06 (rank : 31)	NC score	0.342728 (rank : 32)
Query Neighborhood Hits	92	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_HUMAN
θ value	1.87187e-05 (rank : 32)	NC score	0.374344 (rank : 31)
Query Neighborhood Hits	92	Target Neighborhood Hits	90	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCNB2_HUMAN
θ value	4.1701e-05 (rank : 33)	NC score	0.214094 (rank : 38)
Query Neighborhood Hits	92	Target Neighborhood Hits	212	Shared Neighborhood Hits	55
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNV2_HUMAN
θ value	7.1131e-05 (rank : 34)	NC score	0.232691 (rank : 37)
Query Neighborhood Hits	92	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

PKD2_MOUSE
θ value	0.000121331 (rank : 35)	NC score	0.328247 (rank : 34)
Query Neighborhood Hits	92	Target Neighborhood Hits	99	Shared Neighborhood Hits	37
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
θ value	0.000158464 (rank : 36)	NC score	0.321794 (rank : 35)
Query Neighborhood Hits	92	Target Neighborhood Hits	105	Shared Neighborhood Hits	35
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNB1_HUMAN
θ value	0.000270298 (rank : 37)	NC score	0.201413 (rank : 42)
Query Neighborhood Hits	92	Target Neighborhood Hits	169	Shared Neighborhood Hits	55
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	0.000270298 (rank : 38)	NC score	0.201444 (rank : 41)
Query Neighborhood Hits	92	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

PK2L2_MOUSE
θ value	0.000270298 (rank : 39)	NC score	0.337598 (rank : 33)
Query Neighborhood Hits	92	Target Neighborhood Hits	84	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCNS2_MOUSE
θ value	0.00175202 (rank : 40)	NC score	0.206592 (rank : 39)
Query Neighborhood Hits	92	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCND1_MOUSE
θ value	0.00298849 (rank : 41)	NC score	0.167427 (rank : 48)
Query Neighborhood Hits	92	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCNF1_HUMAN
θ value	0.00298849 (rank : 42)	NC score	0.243274 (rank : 36)
Query Neighborhood Hits	92	Target Neighborhood Hits	109	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNS2_HUMAN
θ value	0.00390308 (rank : 43)	NC score	0.202901 (rank : 40)
Query Neighborhood Hits	92	Target Neighborhood Hits	129	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCND3_HUMAN
θ value	0.00665767 (rank : 44)	NC score	0.183407 (rank : 44)
Query Neighborhood Hits	92	Target Neighborhood Hits	162	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.00665767 (rank : 45)	NC score	0.183528 (rank : 43)
Query Neighborhood Hits	92	Target Neighborhood Hits	162	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND1_HUMAN
θ value	0.0113563 (rank : 46)	NC score	0.163281 (rank : 49)
Query Neighborhood Hits	92	Target Neighborhood Hits	160	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCND2_HUMAN
θ value	0.0113563 (rank : 47)	NC score	0.177044 (rank : 47)
Query Neighborhood Hits	92	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.0113563 (rank : 48)	NC score	0.177206 (rank : 46)
Query Neighborhood Hits	92	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCNS3_HUMAN
θ value	0.0330416 (rank : 49)	NC score	0.179290 (rank : 45)
Query Neighborhood Hits	92	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCNS1_MOUSE
θ value	0.0431538 (rank : 50)	NC score	0.141605 (rank : 51)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	48
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNS1_HUMAN
θ value	0.279714 (rank : 51)	NC score	0.152482 (rank : 50)
Query Neighborhood Hits	92	Target Neighborhood Hits	116	Shared Neighborhood Hits	54
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

TRPA1_HUMAN
θ value	0.365318 (rank : 52)	NC score	0.010458 (rank : 95)
Query Neighborhood Hits	92	Target Neighborhood Hits	339	Shared Neighborhood Hits	9
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

KCNA2_MOUSE
θ value	0.62314 (rank : 53)	NC score	0.084597 (rank : 65)
Query Neighborhood Hits	92	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
θ value	0.813845 (rank : 54)	NC score	0.083575 (rank : 66)
Query Neighborhood Hits	92	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNC3_HUMAN
θ value	0.813845 (rank : 55)	NC score	0.114121 (rank : 57)
Query Neighborhood Hits	92	Target Neighborhood Hits	256	Shared Neighborhood Hits	50
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
θ value	0.813845 (rank : 56)	NC score	0.112727 (rank : 58)
Query Neighborhood Hits	92	Target Neighborhood Hits	173	Shared Neighborhood Hits	49
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

POTE1_MOUSE
θ value	0.813845 (rank : 57)	NC score	0.016058 (rank : 90)
Query Neighborhood Hits	92	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WC1, Q8BUH9	Gene names	Pot1
Domain Architecture	No domain graphic available
Description	Protection of telomeres 1 (mPot1) (POT1-like telomere end-binding protein).

GNPTA_MOUSE
θ value	1.06291 (rank : 58)	NC score	0.012378 (rank : 93)
Query Neighborhood Hits	92	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q69ZN6, Q3U3K6, Q3US34	Gene names	Gnptab, Gnpta, Kiaa1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

KCNQ1_MOUSE
θ value	1.38821 (rank : 59)	NC score	0.075590 (rank : 71)
Query Neighborhood Hits	92	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

MDN1_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.014611 (rank : 91)
Query Neighborhood Hits	92	Target Neighborhood Hits	662	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

CABP4_HUMAN
θ value	3.0926 (rank : 61)	NC score	0.007755 (rank : 98)
Query Neighborhood Hits	92	Target Neighborhood Hits	250	Shared Neighborhood Hits	7
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

ENL_HUMAN
θ value	3.0926 (rank : 62)	NC score	0.007382 (rank : 101)
Query Neighborhood Hits	92	Target Neighborhood Hits	305	Shared Neighborhood Hits	5
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

KCNA1_MOUSE
θ value	4.03905 (rank : 63)	NC score	0.086712 (rank : 63)
Query Neighborhood Hits	92	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

TF3C1_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.007473 (rank : 100)
Query Neighborhood Hits	92	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

TPTE2_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.128676 (rank : 54)
Query Neighborhood Hits	92	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNA1_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.084650 (rank : 64)
Query Neighborhood Hits	92	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

MAST4_HUMAN
θ value	5.27518 (rank : 67)	NC score	-0.002352 (rank : 116)
Query Neighborhood Hits	92	Target Neighborhood Hits	1804	Shared Neighborhood Hits	12
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MYH14_MOUSE
θ value	5.27518 (rank : 68)	NC score	-0.002936 (rank : 117)
Query Neighborhood Hits	92	Target Neighborhood Hits	1225	Shared Neighborhood Hits	8
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

NCOR2_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.009497 (rank : 96)
Query Neighborhood Hits	92	Target Neighborhood Hits	870	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

TFEB_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.009469 (rank : 97)
Query Neighborhood Hits	92	Target Neighborhood Hits	119	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

ACTN2_HUMAN
θ value	6.88961 (rank : 71)	NC score	0.006625 (rank : 104)
Query Neighborhood Hits	92	Target Neighborhood Hits	295	Shared Neighborhood Hits	11
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

CABIN_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.011146 (rank : 94)
Query Neighborhood Hits	92	Target Neighborhood Hits	490	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CP11A_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.000816 (rank : 111)
Query Neighborhood Hits	92	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P05108, Q15081, Q16805	Gene names	CYP11A1, CYP11A
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

DJBP_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.051293 (rank : 87)
Query Neighborhood Hits	92	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

GLUD1_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.006680 (rank : 103)
Query Neighborhood Hits	92	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TDP6, Q9NYJ0	Gene names	GLULD1, LGS
Domain Architecture	No domain graphic available
Description	Glutamate--ammonia ligase domain-containing protein 1 (Lengsin) (Lens glutamine synthase-like).

ILF3_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.007478 (rank : 99)
Query Neighborhood Hits	92	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	Q12906, O43409, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2	Gene names	ILF3, DRBF, MPHOSPH4, NF90
Domain Architecture
Description	Interleukin enhancer-binding factor 3 (Nuclear factor of activated T- cells 90 kDa) (NF-AT-90) (Double-stranded RNA-binding protein 76) (DRBP76) (Translational control protein 80) (TCP80) (Nuclear factor associated with dsRNA) (NFAR) (M-phase phosphoprotein 4) (MPP4).

KCNA6_MOUSE
θ value	6.88961 (rank : 77)	NC score	0.082326 (rank : 68)
Query Neighborhood Hits	92	Target Neighborhood Hits	106	Shared Neighborhood Hits	38
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG1_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.076659 (rank : 69)
Query Neighborhood Hits	92	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

PHLB1_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.007230 (rank : 102)
Query Neighborhood Hits	92	Target Neighborhood Hits	678	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SN_HUMAN
θ value	6.88961 (rank : 80)	NC score	-0.000657 (rank : 114)
Query Neighborhood Hits	92	Target Neighborhood Hits	434	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

TARA_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.019067 (rank : 89)
Query Neighborhood Hits	92	Target Neighborhood Hits	1626	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ACTN2_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.005555 (rank : 105)
Query Neighborhood Hits	92	Target Neighborhood Hits	287	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

COR1A_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.000015 (rank : 113)
Query Neighborhood Hits	92	Target Neighborhood Hits	240	Shared Neighborhood Hits	2
SwissProt Accessions	P31146	Gene names	CORO1A, CORO1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

CRSP7_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.003996 (rank : 107)
Query Neighborhood Hits	92	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

GCYA2_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.001513 (rank : 108)
Query Neighborhood Hits	92	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

K1802_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.000243 (rank : 112)
Query Neighborhood Hits	92	Target Neighborhood Hits	1596	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYPT2_HUMAN
θ value	8.99809 (rank : 87)	NC score	-0.001561 (rank : 115)
Query Neighborhood Hits	92	Target Neighborhood Hits	707	Shared Neighborhood Hits	5
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

NCKX6_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.004265 (rank : 106)
Query Neighborhood Hits	92	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q925Q3, Q3U067, Q80XM7	Gene names	Slc24a6, Nckx6
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 6 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 6) (Solute carrier family 24 member 6).

PDYN_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.013857 (rank : 92)
Query Neighborhood Hits	92	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

SMC3_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.001063 (rank : 110)
Query Neighborhood Hits	92	Target Neighborhood Hits	1186	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	8.99809 (rank : 91)	NC score	0.001084 (rank : 109)
Query Neighborhood Hits	92	Target Neighborhood Hits	1187	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

TPTE_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.088772 (rank : 62)
Query Neighborhood Hits	92	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

KCNA3_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.071256 (rank : 74)
Query Neighborhood Hits	92	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.070369 (rank : 75)
Query Neighborhood Hits	92	Target Neighborhood Hits	103	Shared Neighborhood Hits	32
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.060792 (rank : 81)
Query Neighborhood Hits	92	Target Neighborhood Hits	108	Shared Neighborhood Hits	27
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.061070 (rank : 80)
Query Neighborhood Hits	92	Target Neighborhood Hits	98	Shared Neighborhood Hits	27
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.068332 (rank : 76)
Query Neighborhood Hits	92	Target Neighborhood Hits	124	Shared Neighborhood Hits	32
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.073295 (rank : 72)
Query Neighborhood Hits	92	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.075794 (rank : 70)
Query Neighborhood Hits	92	Target Neighborhood Hits	100	Shared Neighborhood Hits	35
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNC1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.130836 (rank : 52)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.129124 (rank : 53)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC4_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.125243 (rank : 55)
Query Neighborhood Hits	92	Target Neighborhood Hits	141	Shared Neighborhood Hits	50
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.117069 (rank : 56)
Query Neighborhood Hits	92	Target Neighborhood Hits	130	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNG2_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.073049 (rank : 73)
Query Neighborhood Hits	92	Target Neighborhood Hits	83	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG3_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.106229 (rank : 59)
Query Neighborhood Hits	92	Target Neighborhood Hits	91	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.104923 (rank : 60)
Query Neighborhood Hits	92	Target Neighborhood Hits	91	Shared Neighborhood Hits	42
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG4_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.067625 (rank : 77)
Query Neighborhood Hits	92	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.062018 (rank : 79)
Query Neighborhood Hits	92	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ2_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.055555 (rank : 84)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	30
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ2_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.051778 (rank : 85)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ3_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.050842 (rank : 88)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	33
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ4_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.082913 (rank : 67)
Query Neighborhood Hits	92	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.059631 (rank : 82)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

MCLN2_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.056948 (rank : 83)
Query Neighborhood Hits	92	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

PKDRE_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.093217 (rank : 61)
Query Neighborhood Hits	92	Target Neighborhood Hits	64	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.065576 (rank : 78)
Query Neighborhood Hits	92	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TRPV3_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.051733 (rank : 86)
Query Neighborhood Hits	92	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

Hits sorted by NC score

CAC1S_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 12)
Query Neighborhood Hits	92	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
NC score	0.998457 (rank : 2)	θ value	0 (rank : 13)
Query Neighborhood Hits	92	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
NC score	0.995599 (rank : 3)	θ value	0 (rank : 7)
Query Neighborhood Hits	92	Target Neighborhood Hits	118	Shared Neighborhood Hits	60
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1C_MOUSE
NC score	0.994515 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	92	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.993726 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	92	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1F_MOUSE
NC score	0.993549 (rank : 6)	θ value	0 (rank : 11)
Query Neighborhood Hits	92	Target Neighborhood Hits	142	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.993545 (rank : 7)	θ value	0 (rank : 10)
Query Neighborhood Hits	92	Target Neighborhood Hits	141	Shared Neighborhood Hits	59
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1E_MOUSE
NC score	0.961648 (rank : 8)	θ value	0 (rank : 9)
Query Neighborhood Hits	92	Target Neighborhood Hits	167	Shared Neighborhood Hits	52
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.961510 (rank : 9)	θ value	0 (rank : 8)
Query Neighborhood Hits	92	Target Neighborhood Hits	148	Shared Neighborhood Hits	53
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1B_HUMAN
NC score	0.957327 (rank : 10)	θ value	0 (rank : 3)
Query Neighborhood Hits	92	Target Neighborhood Hits	257	Shared Neighborhood Hits	58
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_MOUSE
NC score	0.956604 (rank : 11)	θ value	0 (rank : 2)
Query Neighborhood Hits	92	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.952583 (rank : 12)	θ value	0 (rank : 4)
Query Neighborhood Hits	92	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_HUMAN
NC score	0.948006 (rank : 13)	θ value	0 (rank : 1)
Query Neighborhood Hits	92	Target Neighborhood Hits	387	Shared Neighborhood Hits	59
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1I_HUMAN
NC score	0.900192 (rank : 14)	θ value	1.96316e-71 (rank : 18)
Query Neighborhood Hits	92	Target Neighborhood Hits	138	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.875917 (rank : 15)	θ value	2.4834e-66 (rank : 29)
Query Neighborhood Hits	92	Target Neighborhood Hits	230	Shared Neighborhood Hits	64
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.872252 (rank : 16)	θ value	5.91091e-68 (rank : 22)
Query Neighborhood Hits	92	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

SC11A_MOUSE
NC score	0.864626 (rank : 17)	θ value	8.81223e-72 (rank : 15)
Query Neighborhood Hits	92	Target Neighborhood Hits	116	Shared Neighborhood Hits	60
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC11A_HUMAN
NC score	0.862934 (rank : 18)	θ value	9.41505e-74 (rank : 14)
Query Neighborhood Hits	92	Target Neighborhood Hits	111	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN5A_HUMAN
NC score	0.857126 (rank : 19)	θ value	2.93355e-67 (rank : 25)
Query Neighborhood Hits	92	Target Neighborhood Hits	145	Shared Neighborhood Hits	56
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

CAC1G_HUMAN
NC score	0.856547 (rank : 20)	θ value	1.31681e-67 (rank : 24)
Query Neighborhood Hits	92	Target Neighborhood Hits	587	Shared Neighborhood Hits	61
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN4A_HUMAN
NC score	0.855314 (rank : 21)	θ value	1.19101e-68 (rank : 21)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	61
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN7A_HUMAN
NC score	0.855059 (rank : 22)	θ value	2.18062e-54 (rank : 30)
Query Neighborhood Hits	92	Target Neighborhood Hits	135	Shared Neighborhood Hits	53
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN3A_HUMAN
NC score	0.848750 (rank : 23)	θ value	1.27248e-70 (rank : 19)
Query Neighborhood Hits	92	Target Neighborhood Hits	115	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SC10A_MOUSE
NC score	0.847577 (rank : 24)	θ value	1.50314e-71 (rank : 17)
Query Neighborhood Hits	92	Target Neighborhood Hits	107	Shared Neighborhood Hits	57
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN2A_HUMAN
NC score	0.845884 (rank : 25)	θ value	8.81223e-72 (rank : 16)
Query Neighborhood Hits	92	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN8A_HUMAN
NC score	0.845260 (rank : 26)	θ value	8.53533e-67 (rank : 27)
Query Neighborhood Hits	92	Target Neighborhood Hits	135	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
NC score	0.845106 (rank : 27)	θ value	3.13423e-69 (rank : 20)
Query Neighborhood Hits	92	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN1A_HUMAN
NC score	0.843179 (rank : 28)	θ value	6.53529e-67 (rank : 26)
Query Neighborhood Hits	92	Target Neighborhood Hits	148	Shared Neighborhood Hits	55
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SC10A_HUMAN
NC score	0.842694 (rank : 29)	θ value	5.91091e-68 (rank : 23)
Query Neighborhood Hits	92	Target Neighborhood Hits	116	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN8A_MOUSE
NC score	0.842680 (rank : 30)	θ value	1.45591e-66 (rank : 28)
Query Neighborhood Hits	92	Target Neighborhood Hits	136	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

PK2L2_HUMAN
NC score	0.374344 (rank : 31)	θ value	1.87187e-05 (rank : 32)
Query Neighborhood Hits	92	Target Neighborhood Hits	90	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.342728 (rank : 32)	θ value	4.92598e-06 (rank : 31)
Query Neighborhood Hits	92	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.337598 (rank : 33)	θ value	0.000270298 (rank : 39)
Query Neighborhood Hits	92	Target Neighborhood Hits	84	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_MOUSE
NC score	0.328247 (rank : 34)	θ value	0.000121331 (rank : 35)
Query Neighborhood Hits	92	Target Neighborhood Hits	99	Shared Neighborhood Hits	37
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.321794 (rank : 35)	θ value	0.000158464 (rank : 36)
Query Neighborhood Hits	92	Target Neighborhood Hits	105	Shared Neighborhood Hits	35
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.243274 (rank : 36)	θ value	0.00298849 (rank : 42)
Query Neighborhood Hits	92	Target Neighborhood Hits	109	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNV2_HUMAN
NC score	0.232691 (rank : 37)	θ value	7.1131e-05 (rank : 34)
Query Neighborhood Hits	92	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNB2_HUMAN
NC score	0.214094 (rank : 38)	θ value	4.1701e-05 (rank : 33)
Query Neighborhood Hits	92	Target Neighborhood Hits	212	Shared Neighborhood Hits	55
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS2_MOUSE
NC score	0.206592 (rank : 39)	θ value	0.00175202 (rank : 40)
Query Neighborhood Hits	92	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.202901 (rank : 40)	θ value	0.00390308 (rank : 43)
Query Neighborhood Hits	92	Target Neighborhood Hits	129	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_MOUSE
NC score	0.201444 (rank : 41)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	92	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB1_HUMAN
NC score	0.201413 (rank : 42)	θ value	0.000270298 (rank : 37)
Query Neighborhood Hits	92	Target Neighborhood Hits	169	Shared Neighborhood Hits	55
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCND3_MOUSE
NC score	0.183528 (rank : 43)	θ value	0.00665767 (rank : 45)
Query Neighborhood Hits	92	Target Neighborhood Hits	162	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.183407 (rank : 44)	θ value	0.00665767 (rank : 44)
Query Neighborhood Hits	92	Target Neighborhood Hits	162	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
NC score	0.179290 (rank : 45)	θ value	0.0330416 (rank : 49)
Query Neighborhood Hits	92	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_MOUSE
NC score	0.177206 (rank : 46)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	92	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.177044 (rank : 47)	θ value	0.0113563 (rank : 47)
Query Neighborhood Hits	92	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.167427 (rank : 48)	θ value	0.00298849 (rank : 41)
Query Neighborhood Hits	92	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.163281 (rank : 49)	θ value	0.0113563 (rank : 46)
Query Neighborhood Hits	92	Target Neighborhood Hits	160	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNS1_HUMAN
NC score	0.152482 (rank : 50)	θ value	0.279714 (rank : 51)
Query Neighborhood Hits	92	Target Neighborhood Hits	116	Shared Neighborhood Hits	54
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNS1_MOUSE
NC score	0.141605 (rank : 51)	θ value	0.0431538 (rank : 50)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	48
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC1_HUMAN
NC score	0.130836 (rank : 52)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
NC score	0.129124 (rank : 53)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	92	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

TPTE2_HUMAN
NC score	0.128676 (rank : 54)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	92	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC4_HUMAN
NC score	0.125243 (rank : 55)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	92	Target Neighborhood Hits	141	Shared Neighborhood Hits	50
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
NC score	0.117069 (rank : 56)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	92	Target Neighborhood Hits	130	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_HUMAN
NC score	0.114121 (rank : 57)	θ value	0.813845 (rank : 55)
Query Neighborhood Hits	92	Target Neighborhood Hits	256	Shared Neighborhood Hits	50
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
NC score	0.112727 (rank : 58)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	92	Target Neighborhood Hits	173	Shared Neighborhood Hits	49
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNG3_HUMAN
NC score	0.106229 (rank : 59)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	92	Target Neighborhood Hits	91	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_MOUSE
NC score	0.104923 (rank : 60)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	92	Target Neighborhood Hits	91	Shared Neighborhood Hits	42
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

PKDRE_HUMAN
NC score	0.093217 (rank : 61)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	92	Target Neighborhood Hits	64	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TPTE_HUMAN
NC score	0.088772 (rank : 62)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	92	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

KCNA1_MOUSE
NC score	0.086712 (rank : 63)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	92	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA1_HUMAN
NC score	0.084650 (rank : 64)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	92	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_MOUSE
NC score	0.084597 (rank : 65)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	92	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
NC score	0.083575 (rank : 66)	θ value	0.813845 (rank : 54)
Query Neighborhood Hits	92	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNQ4_HUMAN
NC score	0.082913 (rank : 67)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	92	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNA6_MOUSE
NC score	0.082326 (rank : 68)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	92	Target Neighborhood Hits	106	Shared Neighborhood Hits	38
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG1_HUMAN
NC score	0.076659 (rank : 69)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	92	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNA6_HUMAN
NC score	0.075794 (rank : 70)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	92	Target Neighborhood Hits	100	Shared Neighborhood Hits	35
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNQ1_MOUSE
NC score	0.075590 (rank : 71)	θ value	1.38821 (rank : 59)
Query Neighborhood Hits	92	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA5_MOUSE
NC score	0.073295 (rank : 72)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	92	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNG2_HUMAN
NC score	0.073049 (rank : 73)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	92	Target Neighborhood Hits	83	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNA3_HUMAN
NC score	0.071256 (rank : 74)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	92	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
NC score	0.070369 (rank : 75)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	92	Target Neighborhood Hits	103	Shared Neighborhood Hits	32
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA5_HUMAN
NC score	0.068332 (rank : 76)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	92	Target Neighborhood Hits	124	Shared Neighborhood Hits	32
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNG4_HUMAN
NC score	0.067625 (rank : 77)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	92	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

PKDRE_MOUSE
NC score	0.065576 (rank : 78)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	92	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNQ1_HUMAN
NC score	0.062018 (rank : 79)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	92	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA4_MOUSE
NC score	0.061070 (rank : 80)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	92	Target Neighborhood Hits	98	Shared Neighborhood Hits	27
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA4_HUMAN
NC score	0.060792 (rank : 81)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	92	Target Neighborhood Hits	108	Shared Neighborhood Hits	27
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNQ5_HUMAN
NC score	0.059631 (rank : 82)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

MCLN2_MOUSE
NC score	0.056948 (rank : 83)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	92	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

KCNQ2_HUMAN
NC score	0.055555 (rank : 84)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	30
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ2_MOUSE
NC score	0.051778 (rank : 85)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	92	Target Neighborhood Hits	163	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

TRPV3_HUMAN
NC score	0.051733 (rank : 86)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	92	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

DJBP_MOUSE
NC score	0.051293 (rank : 87)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	92	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

KCNQ3_HUMAN
NC score	0.050842 (rank : 88)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	92	Target Neighborhood Hits	114	Shared Neighborhood Hits	33
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

TARA_HUMAN
NC score	0.019067 (rank : 89)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	92	Target Neighborhood Hits	1626	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

POTE1_MOUSE
NC score	0.016058 (rank : 90)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	92	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WC1, Q8BUH9	Gene names	Pot1
Domain Architecture	No domain graphic available
Description	Protection of telomeres 1 (mPot1) (POT1-like telomere end-binding protein).

MDN1_HUMAN
NC score	0.014611 (rank : 91)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	92	Target Neighborhood Hits	662	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

PDYN_HUMAN
NC score	0.013857 (rank : 92)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	92	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

GNPTA_MOUSE
NC score	0.012378 (rank : 93)	θ value	1.06291 (rank : 58)
Query Neighborhood Hits	92	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q69ZN6, Q3U3K6, Q3US34	Gene names	Gnptab, Gnpta, Kiaa1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

CABIN_HUMAN
NC score	0.011146 (rank : 94)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	92	Target Neighborhood Hits	490	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

TRPA1_HUMAN
NC score	0.010458 (rank : 95)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	92	Target Neighborhood Hits	339	Shared Neighborhood Hits	9
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

NCOR2_HUMAN
NC score	0.009497 (rank : 96)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	92	Target Neighborhood Hits	870	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

TFEB_MOUSE
NC score	0.009469 (rank : 97)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	92	Target Neighborhood Hits	119	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

CABP4_HUMAN
NC score	0.007755 (rank : 98)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	92	Target Neighborhood Hits	250	Shared Neighborhood Hits	7
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

ILF3_HUMAN
NC score	0.007478 (rank : 99)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	92	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	Q12906, O43409, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2	Gene names	ILF3, DRBF, MPHOSPH4, NF90
Domain Architecture
Description	Interleukin enhancer-binding factor 3 (Nuclear factor of activated T- cells 90 kDa) (NF-AT-90) (Double-stranded RNA-binding protein 76) (DRBP76) (Translational control protein 80) (TCP80) (Nuclear factor associated with dsRNA) (NFAR) (M-phase phosphoprotein 4) (MPP4).

TF3C1_HUMAN
NC score	0.007473 (rank : 100)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	92	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

ENL_HUMAN
NC score	0.007382 (rank : 101)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	92	Target Neighborhood Hits	305	Shared Neighborhood Hits	5
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

PHLB1_MOUSE
NC score	0.007230 (rank : 102)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	92	Target Neighborhood Hits	678	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

GLUD1_HUMAN
NC score	0.006680 (rank : 103)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	92	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TDP6, Q9NYJ0	Gene names	GLULD1, LGS
Domain Architecture	No domain graphic available
Description	Glutamate--ammonia ligase domain-containing protein 1 (Lengsin) (Lens glutamine synthase-like).

ACTN2_HUMAN
NC score	0.006625 (rank : 104)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	92	Target Neighborhood Hits	295	Shared Neighborhood Hits	11
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ACTN2_MOUSE
NC score	0.005555 (rank : 105)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	92	Target Neighborhood Hits	287	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

NCKX6_MOUSE
NC score	0.004265 (rank : 106)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	92	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q925Q3, Q3U067, Q80XM7	Gene names	Slc24a6, Nckx6
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 6 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 6) (Solute carrier family 24 member 6).

CRSP7_HUMAN
NC score	0.003996 (rank : 107)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	92	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

GCYA2_HUMAN
NC score	0.001513 (rank : 108)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	92	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

SMC3_MOUSE
NC score	0.001084 (rank : 109)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	92	Target Neighborhood Hits	1187	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.001063 (rank : 110)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	92	Target Neighborhood Hits	1186	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

CP11A_HUMAN
NC score	0.000816 (rank : 111)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	92	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P05108, Q15081, Q16805	Gene names	CYP11A1, CYP11A
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

K1802_MOUSE
NC score	0.000243 (rank : 112)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	92	Target Neighborhood Hits	1596	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

COR1A_HUMAN
NC score	0.000015 (rank : 113)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	92	Target Neighborhood Hits	240	Shared Neighborhood Hits	2
SwissProt Accessions	P31146	Gene names	CORO1A, CORO1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

SN_HUMAN
NC score	-0.000657 (rank : 114)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	92	Target Neighborhood Hits	434	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

MYPT2_HUMAN
NC score	-0.001561 (rank : 115)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	92	Target Neighborhood Hits	707	Shared Neighborhood Hits	5
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

MAST4_HUMAN
NC score	-0.002352 (rank : 116)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	92	Target Neighborhood Hits	1804	Shared Neighborhood Hits	12
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MYH14_MOUSE
NC score	-0.002936 (rank : 117)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	92	Target Neighborhood Hits	1225	Shared Neighborhood Hits	8
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).