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Network neighborhood for query Sequence : SC10A_HUMAN

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SC10A_HUMAN
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SC10A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	116	Target Neighborhood Hits	116	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
θ value	0 (rank : 2)	NC score	0.997183 (rank : 2)
Query Neighborhood Hits	116	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC11A_HUMAN
θ value	0 (rank : 3)	NC score	0.983243 (rank : 12)
Query Neighborhood Hits	116	Target Neighborhood Hits	111	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
θ value	0 (rank : 4)	NC score	0.986145 (rank : 11)
Query Neighborhood Hits	116	Target Neighborhood Hits	116	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
θ value	0 (rank : 5)	NC score	0.992373 (rank : 7)
Query Neighborhood Hits	116	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0 (rank : 6)	NC score	0.992079 (rank : 8)
Query Neighborhood Hits	116	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
θ value	0 (rank : 7)	NC score	0.993277 (rank : 3)
Query Neighborhood Hits	116	Target Neighborhood Hits	115	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
θ value	0 (rank : 8)	NC score	0.989580 (rank : 10)
Query Neighborhood Hits	116	Target Neighborhood Hits	133	Shared Neighborhood Hits	70
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
θ value	0 (rank : 9)	NC score	0.992667 (rank : 4)
Query Neighborhood Hits	116	Target Neighborhood Hits	145	Shared Neighborhood Hits	69
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
θ value	0 (rank : 10)	NC score	0.981513 (rank : 13)
Query Neighborhood Hits	116	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN8A_HUMAN
θ value	0 (rank : 11)	NC score	0.992552 (rank : 5)
Query Neighborhood Hits	116	Target Neighborhood Hits	135	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0 (rank : 12)	NC score	0.992461 (rank : 6)
Query Neighborhood Hits	116	Target Neighborhood Hits	136	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
θ value	0 (rank : 13)	NC score	0.991707 (rank : 9)
Query Neighborhood Hits	116	Target Neighborhood Hits	157	Shared Neighborhood Hits	68
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1H_MOUSE
θ value	2.47765e-74 (rank : 14)	NC score	0.870888 (rank : 15)
Query Neighborhood Hits	116	Target Neighborhood Hits	230	Shared Neighborhood Hits	61
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1S_MOUSE
θ value	1.40689e-69 (rank : 15)	NC score	0.843991 (rank : 21)
Query Neighborhood Hits	116	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
θ value	3.13423e-69 (rank : 16)	NC score	0.843201 (rank : 22)
Query Neighborhood Hits	116	Target Neighborhood Hits	118	Shared Neighborhood Hits	57
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
θ value	5.91091e-68 (rank : 17)	NC score	0.842694 (rank : 23)
Query Neighborhood Hits	116	Target Neighborhood Hits	92	Shared Neighborhood Hits	54
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1A_MOUSE
θ value	2.93355e-67 (rank : 18)	NC score	0.848763 (rank : 19)
Query Neighborhood Hits	116	Target Neighborhood Hits	267	Shared Neighborhood Hits	62
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1I_HUMAN
θ value	1.90147e-66 (rank : 19)	NC score	0.890498 (rank : 14)
Query Neighborhood Hits	116	Target Neighborhood Hits	138	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1A_HUMAN
θ value	4.23606e-66 (rank : 20)	NC score	0.841357 (rank : 25)
Query Neighborhood Hits	116	Target Neighborhood Hits	387	Shared Neighborhood Hits	62
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1E_HUMAN
θ value	7.2256e-66 (rank : 21)	NC score	0.852816 (rank : 18)
Query Neighborhood Hits	116	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	3.58603e-65 (rank : 22)	NC score	0.853254 (rank : 17)
Query Neighborhood Hits	116	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1B_MOUSE
θ value	8.83269e-64 (rank : 23)	NC score	0.839589 (rank : 26)
Query Neighborhood Hits	116	Target Neighborhood Hits	351	Shared Neighborhood Hits	62
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
θ value	1.15359e-63 (rank : 24)	NC score	0.838026 (rank : 27)
Query Neighborhood Hits	116	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
θ value	1.50663e-63 (rank : 25)	NC score	0.835347 (rank : 29)
Query Neighborhood Hits	116	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1F_HUMAN
θ value	7.47731e-63 (rank : 26)	NC score	0.837087 (rank : 28)
Query Neighborhood Hits	116	Target Neighborhood Hits	141	Shared Neighborhood Hits	58
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1G_HUMAN
θ value	4.10295e-61 (rank : 27)	NC score	0.847021 (rank : 20)
Query Neighborhood Hits	116	Target Neighborhood Hits	587	Shared Neighborhood Hits	63
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1B_HUMAN
θ value	5.35859e-61 (rank : 28)	NC score	0.842624 (rank : 24)
Query Neighborhood Hits	116	Target Neighborhood Hits	257	Shared Neighborhood Hits	62
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1H_HUMAN
θ value	1.11734e-58 (rank : 29)	NC score	0.863336 (rank : 16)
Query Neighborhood Hits	116	Target Neighborhood Hits	307	Shared Neighborhood Hits	65
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1C_HUMAN
θ value	2.48917e-58 (rank : 30)	NC score	0.830420 (rank : 30)
Query Neighborhood Hits	116	Target Neighborhood Hits	158	Shared Neighborhood Hits	57
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

KCNS2_MOUSE
θ value	1.43324e-05 (rank : 31)	NC score	0.206304 (rank : 39)
Query Neighborhood Hits	116	Target Neighborhood Hits	130	Shared Neighborhood Hits	54
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
θ value	3.19293e-05 (rank : 32)	NC score	0.201008 (rank : 40)
Query Neighborhood Hits	116	Target Neighborhood Hits	129	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB2_HUMAN
θ value	0.000461057 (rank : 33)	NC score	0.210427 (rank : 38)
Query Neighborhood Hits	116	Target Neighborhood Hits	212	Shared Neighborhood Hits	53
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS3_HUMAN
θ value	0.000602161 (rank : 34)	NC score	0.174968 (rank : 43)
Query Neighborhood Hits	116	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

PKD2_MOUSE
θ value	0.000602161 (rank : 35)	NC score	0.273798 (rank : 34)
Query Neighborhood Hits	116	Target Neighborhood Hits	99	Shared Neighborhood Hits	48
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

KCNF1_HUMAN
θ value	0.00298849 (rank : 36)	NC score	0.226159 (rank : 36)
Query Neighborhood Hits	116	Target Neighborhood Hits	109	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNC1_HUMAN
θ value	0.00390308 (rank : 37)	NC score	0.138547 (rank : 51)
Query Neighborhood Hits	116	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
θ value	0.00509761 (rank : 38)	NC score	0.136226 (rank : 53)
Query Neighborhood Hits	116	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

PK2L2_MOUSE
θ value	0.00665767 (rank : 39)	NC score	0.273964 (rank : 33)
Query Neighborhood Hits	116	Target Neighborhood Hits	84	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

BRD2_HUMAN
θ value	0.00869519 (rank : 40)	NC score	0.016697 (rank : 105)
Query Neighborhood Hits	116	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

PKD2_HUMAN
θ value	0.0113563 (rank : 41)	NC score	0.268482 (rank : 35)
Query Neighborhood Hits	116	Target Neighborhood Hits	105	Shared Neighborhood Hits	48
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PKDRE_MOUSE
θ value	0.0148317 (rank : 42)	NC score	0.107034 (rank : 60)
Query Neighborhood Hits	116	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNB1_HUMAN
θ value	0.0252991 (rank : 43)	NC score	0.189933 (rank : 42)
Query Neighborhood Hits	116	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	0.0252991 (rank : 44)	NC score	0.189985 (rank : 41)
Query Neighborhood Hits	116	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

PKDRE_HUMAN
θ value	0.0252991 (rank : 45)	NC score	0.132002 (rank : 54)
Query Neighborhood Hits	116	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNV2_HUMAN
θ value	0.0431538 (rank : 46)	NC score	0.210664 (rank : 37)
Query Neighborhood Hits	116	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

PK2L2_HUMAN
θ value	0.0431538 (rank : 47)	NC score	0.308681 (rank : 31)
Query Neighborhood Hits	116	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCND3_HUMAN
θ value	0.0736092 (rank : 48)	NC score	0.170419 (rank : 45)
Query Neighborhood Hits	116	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.0736092 (rank : 49)	NC score	0.170557 (rank : 44)
Query Neighborhood Hits	116	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNQ4_HUMAN
θ value	0.0736092 (rank : 50)	NC score	0.080788 (rank : 65)
Query Neighborhood Hits	116	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

TAU_HUMAN
θ value	0.0736092 (rank : 51)	NC score	0.020025 (rank : 99)
Query Neighborhood Hits	116	Target Neighborhood Hits	448	Shared Neighborhood Hits	8
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

KCND1_HUMAN
θ value	0.125558 (rank : 52)	NC score	0.143644 (rank : 49)
Query Neighborhood Hits	116	Target Neighborhood Hits	160	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCND2_HUMAN
θ value	0.125558 (rank : 53)	NC score	0.163136 (rank : 47)
Query Neighborhood Hits	116	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.125558 (rank : 54)	NC score	0.163320 (rank : 46)
Query Neighborhood Hits	116	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCNS1_MOUSE
θ value	0.125558 (rank : 55)	NC score	0.120629 (rank : 55)
Query Neighborhood Hits	116	Target Neighborhood Hits	114	Shared Neighborhood Hits	46
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNS1_HUMAN
θ value	0.163984 (rank : 56)	NC score	0.138700 (rank : 50)
Query Neighborhood Hits	116	Target Neighborhood Hits	116	Shared Neighborhood Hits	52
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

TRPC5_HUMAN
θ value	0.163984 (rank : 57)	NC score	0.033452 (rank : 96)
Query Neighborhood Hits	116	Target Neighborhood Hits	122	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
θ value	0.163984 (rank : 58)	NC score	0.033444 (rank : 97)
Query Neighborhood Hits	116	Target Neighborhood Hits	124	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

KCND1_MOUSE
θ value	0.21417 (rank : 59)	NC score	0.145397 (rank : 48)
Query Neighborhood Hits	116	Target Neighborhood Hits	165	Shared Neighborhood Hits	52
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

TRPV4_HUMAN
θ value	0.21417 (rank : 60)	NC score	0.067138 (rank : 79)
Query Neighborhood Hits	116	Target Neighborhood Hits	150	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

GOGA2_HUMAN
θ value	0.279714 (rank : 61)	NC score	0.003805 (rank : 121)
Query Neighborhood Hits	116	Target Neighborhood Hits	856	Shared Neighborhood Hits	5
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

PK2L1_HUMAN
θ value	0.279714 (rank : 62)	NC score	0.286213 (rank : 32)
Query Neighborhood Hits	116	Target Neighborhood Hits	132	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

TRPV4_MOUSE
θ value	0.365318 (rank : 63)	NC score	0.068542 (rank : 76)
Query Neighborhood Hits	116	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TPTE2_HUMAN
θ value	0.47712 (rank : 64)	NC score	0.137739 (rank : 52)
Query Neighborhood Hits	116	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

LC7L2_MOUSE
θ value	0.813845 (rank : 65)	NC score	0.017039 (rank : 104)
Query Neighborhood Hits	116	Target Neighborhood Hits	244	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TNC4, Q99LM5, Q99PC3	Gene names	Luc7l2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog).

NCOAT_HUMAN
θ value	0.813845 (rank : 66)	NC score	0.020274 (rank : 98)
Query Neighborhood Hits	116	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0	Gene names	MGEA5, HEXC, KIAA0679, MEA5
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

LC7L2_HUMAN
θ value	1.06291 (rank : 67)	NC score	0.017130 (rank : 103)
Query Neighborhood Hits	116	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y383, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1	Gene names	LUC7L2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2.

NCOAT_MOUSE
θ value	1.06291 (rank : 68)	NC score	0.019677 (rank : 100)
Query Neighborhood Hits	116	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQQ9, Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7	Gene names	Mgea5, Hexc, Kiaa0679
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

TRPC4_HUMAN
θ value	1.06291 (rank : 69)	NC score	0.051671 (rank : 90)
Query Neighborhood Hits	116	Target Neighborhood Hits	140	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

ZN185_HUMAN
θ value	1.06291 (rank : 70)	NC score	0.014716 (rank : 106)
Query Neighborhood Hits	116	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

MYST3_MOUSE
θ value	1.38821 (rank : 71)	NC score	0.007068 (rank : 112)
Query Neighborhood Hits	116	Target Neighborhood Hits	688	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

OGFR_HUMAN
θ value	1.38821 (rank : 72)	NC score	0.007584 (rank : 111)
Query Neighborhood Hits	116	Target Neighborhood Hits	1582	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PDXL2_MOUSE
θ value	1.38821 (rank : 73)	NC score	0.011344 (rank : 108)
Query Neighborhood Hits	116	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

TRPC4_MOUSE
θ value	1.38821 (rank : 74)	NC score	0.050864 (rank : 91)
Query Neighborhood Hits	116	Target Neighborhood Hits	141	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPV1_HUMAN
θ value	1.38821 (rank : 75)	NC score	0.045888 (rank : 92)
Query Neighborhood Hits	116	Target Neighborhood Hits	184	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	1.38821 (rank : 76)	NC score	0.034109 (rank : 95)
Query Neighborhood Hits	116	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

KCNQ1_HUMAN
θ value	1.81305 (rank : 77)	NC score	0.062905 (rank : 83)
Query Neighborhood Hits	116	Target Neighborhood Hits	99	Shared Neighborhood Hits	30
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

TRPC1_HUMAN
θ value	1.81305 (rank : 78)	NC score	0.077093 (rank : 67)
Query Neighborhood Hits	116	Target Neighborhood Hits	91	Shared Neighborhood Hits	27
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	1.81305 (rank : 79)	NC score	0.077196 (rank : 66)
Query Neighborhood Hits	116	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

ZFP28_HUMAN
θ value	1.81305 (rank : 80)	NC score	-0.004118 (rank : 135)
Query Neighborhood Hits	116	Target Neighborhood Hits	843	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NHY6, Q9BY30, Q9P2B6	Gene names	ZFP28, KIAA1431
Domain Architecture
Description	Zinc finger protein 28 homolog (Zfp-28) (Krueppel-like zinc finger factor X6).

AR13B_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.006968 (rank : 113)
Query Neighborhood Hits	116	Target Neighborhood Hits	528	Shared Neighborhood Hits	7
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

KCNG3_MOUSE
θ value	2.36792 (rank : 82)	NC score	0.088852 (rank : 63)
Query Neighborhood Hits	116	Target Neighborhood Hits	91	Shared Neighborhood Hits	40
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

MTSS1_HUMAN
θ value	2.36792 (rank : 83)	NC score	0.009704 (rank : 110)
Query Neighborhood Hits	116	Target Neighborhood Hits	504	Shared Neighborhood Hits	6
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

TRPM8_MOUSE
θ value	2.36792 (rank : 84)	NC score	0.044653 (rank : 93)
Query Neighborhood Hits	116	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPV3_HUMAN
θ value	2.36792 (rank : 85)	NC score	0.097779 (rank : 61)
Query Neighborhood Hits	116	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

M3K13_HUMAN
θ value	3.0926 (rank : 86)	NC score	-0.004701 (rank : 136)
Query Neighborhood Hits	116	Target Neighborhood Hits	911	Shared Neighborhood Hits	3
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

SIP1_MOUSE
θ value	3.0926 (rank : 87)	NC score	-0.002843 (rank : 132)
Query Neighborhood Hits	116	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

CABP5_MOUSE
θ value	4.03905 (rank : 88)	NC score	0.053196 (rank : 88)
Query Neighborhood Hits	116	Target Neighborhood Hits	207	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

CHD4_HUMAN
θ value	4.03905 (rank : 89)	NC score	0.002495 (rank : 124)
Query Neighborhood Hits	116	Target Neighborhood Hits	365	Shared Neighborhood Hits	5
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	4.03905 (rank : 90)	NC score	0.002486 (rank : 125)
Query Neighborhood Hits	116	Target Neighborhood Hits	408	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

OTX2_HUMAN
θ value	4.03905 (rank : 91)	NC score	0.001000 (rank : 129)
Query Neighborhood Hits	116	Target Neighborhood Hits	341	Shared Neighborhood Hits	3
SwissProt Accessions	P32243, Q6GTV3, Q9HAW3, Q9P2R1	Gene names	OTX2
Domain Architecture
Description	Homeobox protein OTX2.

OTX2_MOUSE
θ value	4.03905 (rank : 92)	NC score	0.001041 (rank : 128)
Query Neighborhood Hits	116	Target Neighborhood Hits	345	Shared Neighborhood Hits	5
SwissProt Accessions	P80206	Gene names	Otx2, Otx-2
Domain Architecture
Description	Homeobox protein OTX2.

RBL2_MOUSE
θ value	4.03905 (rank : 93)	NC score	0.005308 (rank : 117)
Query Neighborhood Hits	116	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q64700	Gene names	Rbl2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

WNK4_HUMAN
θ value	4.03905 (rank : 94)	NC score	-0.002637 (rank : 131)
Query Neighborhood Hits	116	Target Neighborhood Hits	1043	Shared Neighborhood Hits	9
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ZN445_HUMAN
θ value	4.03905 (rank : 95)	NC score	-0.004111 (rank : 134)
Query Neighborhood Hits	116	Target Neighborhood Hits	764	Shared Neighborhood Hits	5
SwissProt Accessions	P59923	Gene names	ZNF445, ZNF168
Domain Architecture
Description	Zinc finger protein 445.

ASXL1_MOUSE
θ value	5.27518 (rank : 96)	NC score	0.005650 (rank : 115)
Query Neighborhood Hits	116	Target Neighborhood Hits	182	Shared Neighborhood Hits	2
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

KCNG3_HUMAN
θ value	5.27518 (rank : 97)	NC score	0.088447 (rank : 64)
Query Neighborhood Hits	116	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNQ1_MOUSE
θ value	5.27518 (rank : 98)	NC score	0.070847 (rank : 73)
Query Neighborhood Hits	116	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

TPTE_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.093258 (rank : 62)
Query Neighborhood Hits	116	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

CIR_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.004035 (rank : 119)
Query Neighborhood Hits	116	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

HRH1_HUMAN
θ value	6.88961 (rank : 101)	NC score	-0.001328 (rank : 130)
Query Neighborhood Hits	116	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	P35367	Gene names	HRH1
Domain Architecture
Description	Histamine H1 receptor.

HS90B_HUMAN
θ value	6.88961 (rank : 102)	NC score	0.003020 (rank : 123)
Query Neighborhood Hits	116	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	P08238, Q5T9W7, Q9NQW0	Gene names	HSP90AB1, HSP90B, HSPC2, HSPCB
Domain Architecture
Description	Heat shock protein HSP 90-beta (HSP 84) (HSP 90).

K1967_MOUSE
θ value	6.88961 (rank : 103)	NC score	0.004094 (rank : 118)
Query Neighborhood Hits	116	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDP4, Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1967 homolog.

SIP1_HUMAN
θ value	6.88961 (rank : 104)	NC score	-0.003206 (rank : 133)
Query Neighborhood Hits	116	Target Neighborhood Hits	832	Shared Neighborhood Hits	5
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

TOP1_MOUSE
θ value	6.88961 (rank : 105)	NC score	0.003591 (rank : 122)
Query Neighborhood Hits	116	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

TRPV3_MOUSE
θ value	6.88961 (rank : 106)	NC score	0.070190 (rank : 74)
Query Neighborhood Hits	116	Target Neighborhood Hits	188	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

CAC2D_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.003993 (rank : 120)
Query Neighborhood Hits	116	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

DHX29_MOUSE
θ value	8.99809 (rank : 108)	NC score	0.001191 (rank : 127)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9	Gene names	Dhx29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29).

LBR_HUMAN
θ value	8.99809 (rank : 109)	NC score	0.013578 (rank : 107)
Query Neighborhood Hits	116	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q14739, Q14740, Q53GU7, Q59FE6	Gene names	LBR
Domain Architecture
Description	Lamin-B receptor (Integral nuclear envelope inner membrane protein) (LMN2R).

LUC7L_MOUSE
θ value	8.99809 (rank : 110)	NC score	0.010678 (rank : 109)
Query Neighborhood Hits	116	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYI4, Q8K247, Q9CWM1	Gene names	Luc7l
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 1.

MTSS1_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.006906 (rank : 114)
Query Neighborhood Hits	116	Target Neighborhood Hits	592	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

TEX9_MOUSE
θ value	8.99809 (rank : 112)	NC score	0.005466 (rank : 116)
Query Neighborhood Hits	116	Target Neighborhood Hits	581	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

TRPC7_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.019463 (rank : 102)
Query Neighborhood Hits	116	Target Neighborhood Hits	123	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC7_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.019526 (rank : 101)
Query Neighborhood Hits	116	Target Neighborhood Hits	114	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPM8_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.038364 (rank : 94)
Query Neighborhood Hits	116	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

ZHX3_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.001231 (rank : 126)
Query Neighborhood Hits	116	Target Neighborhood Hits	331	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H4I2, O43145	Gene names	ZHX3, KIAA0395, TIX1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

KCNA1_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.075473 (rank : 69)
Query Neighborhood Hits	116	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.076815 (rank : 68)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.073780 (rank : 71)
Query Neighborhood Hits	116	Target Neighborhood Hits	101	Shared Neighborhood Hits	33
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.074583 (rank : 70)
Query Neighborhood Hits	116	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA3_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.066854 (rank : 80)
Query Neighborhood Hits	116	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.065882 (rank : 81)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	30
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.053172 (rank : 89)
Query Neighborhood Hits	116	Target Neighborhood Hits	108	Shared Neighborhood Hits	25
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.053627 (rank : 87)
Query Neighborhood Hits	116	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.062984 (rank : 82)
Query Neighborhood Hits	116	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.068211 (rank : 77)
Query Neighborhood Hits	116	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.068586 (rank : 75)
Query Neighborhood Hits	116	Target Neighborhood Hits	100	Shared Neighborhood Hits	33
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA6_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.071210 (rank : 72)
Query Neighborhood Hits	116	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNC3_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.111429 (rank : 57)
Query Neighborhood Hits	116	Target Neighborhood Hits	256	Shared Neighborhood Hits	51
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.109154 (rank : 59)
Query Neighborhood Hits	116	Target Neighborhood Hits	173	Shared Neighborhood Hits	50
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC4_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.117792 (rank : 56)
Query Neighborhood Hits	116	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.111224 (rank : 58)
Query Neighborhood Hits	116	Target Neighborhood Hits	130	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNG1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.067282 (rank : 78)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNG2_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.062173 (rank : 84)
Query Neighborhood Hits	116	Target Neighborhood Hits	83	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG4_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.060305 (rank : 85)
Query Neighborhood Hits	116	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.057038 (rank : 86)
Query Neighborhood Hits	116	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

Hits sorted by NC score

SC10A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	116	Target Neighborhood Hits	116	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
NC score	0.997183 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	116	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN3A_HUMAN
NC score	0.993277 (rank : 3)	θ value	0 (rank : 7)
Query Neighborhood Hits	116	Target Neighborhood Hits	115	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN5A_HUMAN
NC score	0.992667 (rank : 4)	θ value	0 (rank : 9)
Query Neighborhood Hits	116	Target Neighborhood Hits	145	Shared Neighborhood Hits	69
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN8A_HUMAN
NC score	0.992552 (rank : 5)	θ value	0 (rank : 11)
Query Neighborhood Hits	116	Target Neighborhood Hits	135	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
NC score	0.992461 (rank : 6)	θ value	0 (rank : 12)
Query Neighborhood Hits	116	Target Neighborhood Hits	136	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN1A_HUMAN
NC score	0.992373 (rank : 7)	θ value	0 (rank : 5)
Query Neighborhood Hits	116	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
NC score	0.992079 (rank : 8)	θ value	0 (rank : 6)
Query Neighborhood Hits	116	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN9A_HUMAN
NC score	0.991707 (rank : 9)	θ value	0 (rank : 13)
Query Neighborhood Hits	116	Target Neighborhood Hits	157	Shared Neighborhood Hits	68
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN4A_HUMAN
NC score	0.989580 (rank : 10)	θ value	0 (rank : 8)
Query Neighborhood Hits	116	Target Neighborhood Hits	133	Shared Neighborhood Hits	70
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SC11A_MOUSE
NC score	0.986145 (rank : 11)	θ value	0 (rank : 4)
Query Neighborhood Hits	116	Target Neighborhood Hits	116	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC11A_HUMAN
NC score	0.983243 (rank : 12)	θ value	0 (rank : 3)
Query Neighborhood Hits	116	Target Neighborhood Hits	111	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN7A_HUMAN
NC score	0.981513 (rank : 13)	θ value	0 (rank : 10)
Query Neighborhood Hits	116	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

CAC1I_HUMAN
NC score	0.890498 (rank : 14)	θ value	1.90147e-66 (rank : 19)
Query Neighborhood Hits	116	Target Neighborhood Hits	138	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.870888 (rank : 15)	θ value	2.47765e-74 (rank : 14)
Query Neighborhood Hits	116	Target Neighborhood Hits	230	Shared Neighborhood Hits	61
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.863336 (rank : 16)	θ value	1.11734e-58 (rank : 29)
Query Neighborhood Hits	116	Target Neighborhood Hits	307	Shared Neighborhood Hits	65
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_MOUSE
NC score	0.853254 (rank : 17)	θ value	3.58603e-65 (rank : 22)
Query Neighborhood Hits	116	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.852816 (rank : 18)	θ value	7.2256e-66 (rank : 21)
Query Neighborhood Hits	116	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1A_MOUSE
NC score	0.848763 (rank : 19)	θ value	2.93355e-67 (rank : 18)
Query Neighborhood Hits	116	Target Neighborhood Hits	267	Shared Neighborhood Hits	62
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1G_HUMAN
NC score	0.847021 (rank : 20)	θ value	4.10295e-61 (rank : 27)
Query Neighborhood Hits	116	Target Neighborhood Hits	587	Shared Neighborhood Hits	63
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1S_MOUSE
NC score	0.843991 (rank : 21)	θ value	1.40689e-69 (rank : 15)
Query Neighborhood Hits	116	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
NC score	0.843201 (rank : 22)	θ value	3.13423e-69 (rank : 16)
Query Neighborhood Hits	116	Target Neighborhood Hits	118	Shared Neighborhood Hits	57
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
NC score	0.842694 (rank : 23)	θ value	5.91091e-68 (rank : 17)
Query Neighborhood Hits	116	Target Neighborhood Hits	92	Shared Neighborhood Hits	54
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_HUMAN
NC score	0.842624 (rank : 24)	θ value	5.35859e-61 (rank : 28)
Query Neighborhood Hits	116	Target Neighborhood Hits	257	Shared Neighborhood Hits	62
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_HUMAN
NC score	0.841357 (rank : 25)	θ value	4.23606e-66 (rank : 20)
Query Neighborhood Hits	116	Target Neighborhood Hits	387	Shared Neighborhood Hits	62
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.839589 (rank : 26)	θ value	8.83269e-64 (rank : 23)
Query Neighborhood Hits	116	Target Neighborhood Hits	351	Shared Neighborhood Hits	62
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
NC score	0.838026 (rank : 27)	θ value	1.15359e-63 (rank : 24)
Query Neighborhood Hits	116	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.837087 (rank : 28)	θ value	7.47731e-63 (rank : 26)
Query Neighborhood Hits	116	Target Neighborhood Hits	141	Shared Neighborhood Hits	58
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.835347 (rank : 29)	θ value	1.50663e-63 (rank : 25)
Query Neighborhood Hits	116	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.830420 (rank : 30)	θ value	2.48917e-58 (rank : 30)
Query Neighborhood Hits	116	Target Neighborhood Hits	158	Shared Neighborhood Hits	57
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PK2L2_HUMAN
NC score	0.308681 (rank : 31)	θ value	0.0431538 (rank : 47)
Query Neighborhood Hits	116	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.286213 (rank : 32)	θ value	0.279714 (rank : 62)
Query Neighborhood Hits	116	Target Neighborhood Hits	132	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.273964 (rank : 33)	θ value	0.00665767 (rank : 39)
Query Neighborhood Hits	116	Target Neighborhood Hits	84	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_MOUSE
NC score	0.273798 (rank : 34)	θ value	0.000602161 (rank : 35)
Query Neighborhood Hits	116	Target Neighborhood Hits	99	Shared Neighborhood Hits	48
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.268482 (rank : 35)	θ value	0.0113563 (rank : 41)
Query Neighborhood Hits	116	Target Neighborhood Hits	105	Shared Neighborhood Hits	48
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.226159 (rank : 36)	θ value	0.00298849 (rank : 36)
Query Neighborhood Hits	116	Target Neighborhood Hits	109	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNV2_HUMAN
NC score	0.210664 (rank : 37)	θ value	0.0431538 (rank : 46)
Query Neighborhood Hits	116	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNB2_HUMAN
NC score	0.210427 (rank : 38)	θ value	0.000461057 (rank : 33)
Query Neighborhood Hits	116	Target Neighborhood Hits	212	Shared Neighborhood Hits	53
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS2_MOUSE
NC score	0.206304 (rank : 39)	θ value	1.43324e-05 (rank : 31)
Query Neighborhood Hits	116	Target Neighborhood Hits	130	Shared Neighborhood Hits	54
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.201008 (rank : 40)	θ value	3.19293e-05 (rank : 32)
Query Neighborhood Hits	116	Target Neighborhood Hits	129	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_MOUSE
NC score	0.189985 (rank : 41)	θ value	0.0252991 (rank : 44)
Query Neighborhood Hits	116	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB1_HUMAN
NC score	0.189933 (rank : 42)	θ value	0.0252991 (rank : 43)
Query Neighborhood Hits	116	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNS3_HUMAN
NC score	0.174968 (rank : 43)	θ value	0.000602161 (rank : 34)
Query Neighborhood Hits	116	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND3_MOUSE
NC score	0.170557 (rank : 44)	θ value	0.0736092 (rank : 49)
Query Neighborhood Hits	116	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.170419 (rank : 45)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	116	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND2_MOUSE
NC score	0.163320 (rank : 46)	θ value	0.125558 (rank : 54)
Query Neighborhood Hits	116	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.163136 (rank : 47)	θ value	0.125558 (rank : 53)
Query Neighborhood Hits	116	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.145397 (rank : 48)	θ value	0.21417 (rank : 59)
Query Neighborhood Hits	116	Target Neighborhood Hits	165	Shared Neighborhood Hits	52
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.143644 (rank : 49)	θ value	0.125558 (rank : 52)
Query Neighborhood Hits	116	Target Neighborhood Hits	160	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNS1_HUMAN
NC score	0.138700 (rank : 50)	θ value	0.163984 (rank : 56)
Query Neighborhood Hits	116	Target Neighborhood Hits	116	Shared Neighborhood Hits	52
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC1_HUMAN
NC score	0.138547 (rank : 51)	θ value	0.00390308 (rank : 37)
Query Neighborhood Hits	116	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

TPTE2_HUMAN
NC score	0.137739 (rank : 52)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	116	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC1_MOUSE
NC score	0.136226 (rank : 53)	θ value	0.00509761 (rank : 38)
Query Neighborhood Hits	116	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

PKDRE_HUMAN
NC score	0.132002 (rank : 54)	θ value	0.0252991 (rank : 45)
Query Neighborhood Hits	116	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNS1_MOUSE
NC score	0.120629 (rank : 55)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	116	Target Neighborhood Hits	114	Shared Neighborhood Hits	46
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_HUMAN
NC score	0.117792 (rank : 56)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	116	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC3_HUMAN
NC score	0.111429 (rank : 57)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	116	Target Neighborhood Hits	256	Shared Neighborhood Hits	51
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC4_MOUSE
NC score	0.111224 (rank : 58)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	116	Target Neighborhood Hits	130	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_MOUSE
NC score	0.109154 (rank : 59)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	116	Target Neighborhood Hits	173	Shared Neighborhood Hits	50
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

PKDRE_MOUSE
NC score	0.107034 (rank : 60)	θ value	0.0148317 (rank : 42)
Query Neighborhood Hits	116	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TRPV3_HUMAN
NC score	0.097779 (rank : 61)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	116	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TPTE_HUMAN
NC score	0.093258 (rank : 62)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	116	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

KCNG3_MOUSE
NC score	0.088852 (rank : 63)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	116	Target Neighborhood Hits	91	Shared Neighborhood Hits	40
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_HUMAN
NC score	0.088447 (rank : 64)	θ value	5.27518 (rank : 97)
Query Neighborhood Hits	116	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNQ4_HUMAN
NC score	0.080788 (rank : 65)	θ value	0.0736092 (rank : 50)
Query Neighborhood Hits	116	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

TRPC1_MOUSE
NC score	0.077196 (rank : 66)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	116	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.077093 (rank : 67)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	116	Target Neighborhood Hits	91	Shared Neighborhood Hits	27
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

KCNA1_MOUSE
NC score	0.076815 (rank : 68)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA1_HUMAN
NC score	0.075473 (rank : 69)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	116	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_MOUSE
NC score	0.074583 (rank : 70)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	116	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
NC score	0.073780 (rank : 71)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	116	Target Neighborhood Hits	101	Shared Neighborhood Hits	33
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA6_MOUSE
NC score	0.071210 (rank : 72)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	116	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNQ1_MOUSE
NC score	0.070847 (rank : 73)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	116	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

TRPV3_MOUSE
NC score	0.070190 (rank : 74)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	116	Target Neighborhood Hits	188	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

KCNA6_HUMAN
NC score	0.068586 (rank : 75)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	116	Target Neighborhood Hits	100	Shared Neighborhood Hits	33
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

TRPV4_MOUSE
NC score	0.068542 (rank : 76)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	116	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

KCNA5_MOUSE
NC score	0.068211 (rank : 77)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	116	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNG1_HUMAN
NC score	0.067282 (rank : 78)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

TRPV4_HUMAN
NC score	0.067138 (rank : 79)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	116	Target Neighborhood Hits	150	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

KCNA3_HUMAN
NC score	0.066854 (rank : 80)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	116	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
NC score	0.065882 (rank : 81)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	30
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA5_HUMAN
NC score	0.062984 (rank : 82)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	116	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNQ1_HUMAN
NC score	0.062905 (rank : 83)	θ value	1.81305 (rank : 77)
Query Neighborhood Hits	116	Target Neighborhood Hits	99	Shared Neighborhood Hits	30
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNG2_HUMAN
NC score	0.062173 (rank : 84)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	116	Target Neighborhood Hits	83	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG4_HUMAN
NC score	0.060305 (rank : 85)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	116	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ5_HUMAN
NC score	0.057038 (rank : 86)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	116	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

KCNA4_MOUSE
NC score	0.053627 (rank : 87)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	116	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

CABP5_MOUSE
NC score	0.053196 (rank : 88)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	116	Target Neighborhood Hits	207	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCNA4_HUMAN
NC score	0.053172 (rank : 89)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	116	Target Neighborhood Hits	108	Shared Neighborhood Hits	25
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

TRPC4_HUMAN
NC score	0.051671 (rank : 90)	θ value	1.06291 (rank : 69)
Query Neighborhood Hits	116	Target Neighborhood Hits	140	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.050864 (rank : 91)	θ value	1.38821 (rank : 74)
Query Neighborhood Hits	116	Target Neighborhood Hits	141	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPV1_HUMAN
NC score	0.045888 (rank : 92)	θ value	1.38821 (rank : 75)
Query Neighborhood Hits	116	Target Neighborhood Hits	184	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPM8_MOUSE
NC score	0.044653 (rank : 93)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	116	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPM8_HUMAN
NC score	0.038364 (rank : 94)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	116	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPV1_MOUSE
NC score	0.034109 (rank : 95)	θ value	1.38821 (rank : 76)
Query Neighborhood Hits	116	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPC5_HUMAN
NC score	0.033452 (rank : 96)	θ value	0.163984 (rank : 57)
Query Neighborhood Hits	116	Target Neighborhood Hits	122	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
NC score	0.033444 (rank : 97)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	116	Target Neighborhood Hits	124	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

NCOAT_HUMAN
NC score	0.020274 (rank : 98)	θ value	0.813845 (rank : 66)
Query Neighborhood Hits	116	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0	Gene names	MGEA5, HEXC, KIAA0679, MEA5
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

TAU_HUMAN
NC score	0.020025 (rank : 99)	θ value	0.0736092 (rank : 51)
Query Neighborhood Hits	116	Target Neighborhood Hits	448	Shared Neighborhood Hits	8
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

NCOAT_MOUSE
NC score	0.019677 (rank : 100)	θ value	1.06291 (rank : 68)
Query Neighborhood Hits	116	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQQ9, Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7	Gene names	Mgea5, Hexc, Kiaa0679
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

TRPC7_MOUSE
NC score	0.019526 (rank : 101)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	116	Target Neighborhood Hits	114	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPC7_HUMAN
NC score	0.019463 (rank : 102)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	116	Target Neighborhood Hits	123	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

LC7L2_HUMAN
NC score	0.017130 (rank : 103)	θ value	1.06291 (rank : 67)
Query Neighborhood Hits	116	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y383, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1	Gene names	LUC7L2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2.

LC7L2_MOUSE
NC score	0.017039 (rank : 104)	θ value	0.813845 (rank : 65)
Query Neighborhood Hits	116	Target Neighborhood Hits	244	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TNC4, Q99LM5, Q99PC3	Gene names	Luc7l2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog).

BRD2_HUMAN
NC score	0.016697 (rank : 105)	θ value	0.00869519 (rank : 40)
Query Neighborhood Hits	116	Target Neighborhood Hits	242	Shared Neighborhood Hits	3
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

ZN185_HUMAN
NC score	0.014716 (rank : 106)	θ value	1.06291 (rank : 70)
Query Neighborhood Hits	116	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

LBR_HUMAN
NC score	0.013578 (rank : 107)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	116	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q14739, Q14740, Q53GU7, Q59FE6	Gene names	LBR
Domain Architecture
Description	Lamin-B receptor (Integral nuclear envelope inner membrane protein) (LMN2R).

PDXL2_MOUSE
NC score	0.011344 (rank : 108)	θ value	1.38821 (rank : 73)
Query Neighborhood Hits	116	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

LUC7L_MOUSE
NC score	0.010678 (rank : 109)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	116	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYI4, Q8K247, Q9CWM1	Gene names	Luc7l
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 1.

MTSS1_HUMAN
NC score	0.009704 (rank : 110)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	116	Target Neighborhood Hits	504	Shared Neighborhood Hits	6
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

OGFR_HUMAN
NC score	0.007584 (rank : 111)	θ value	1.38821 (rank : 72)
Query Neighborhood Hits	116	Target Neighborhood Hits	1582	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

MYST3_MOUSE
NC score	0.007068 (rank : 112)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	116	Target Neighborhood Hits	688	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

AR13B_HUMAN
NC score	0.006968 (rank : 113)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	116	Target Neighborhood Hits	528	Shared Neighborhood Hits	7
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

MTSS1_MOUSE
NC score	0.006906 (rank : 114)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	116	Target Neighborhood Hits	592	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

ASXL1_MOUSE
NC score	0.005650 (rank : 115)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	116	Target Neighborhood Hits	182	Shared Neighborhood Hits	2
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

TEX9_MOUSE
NC score	0.005466 (rank : 116)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	116	Target Neighborhood Hits	581	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

RBL2_MOUSE
NC score	0.005308 (rank : 117)	θ value	4.03905 (rank : 93)
Query Neighborhood Hits	116	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q64700	Gene names	Rbl2
Domain Architecture
Description	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).

K1967_MOUSE
NC score	0.004094 (rank : 118)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	116	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDP4, Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1967 homolog.

CIR_MOUSE
NC score	0.004035 (rank : 119)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	116	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

CAC2D_MOUSE
NC score	0.003993 (rank : 120)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	116	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

GOGA2_HUMAN
NC score	0.003805 (rank : 121)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	116	Target Neighborhood Hits	856	Shared Neighborhood Hits	5
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

TOP1_MOUSE
NC score	0.003591 (rank : 122)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	116	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

HS90B_HUMAN
NC score	0.003020 (rank : 123)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	116	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	P08238, Q5T9W7, Q9NQW0	Gene names	HSP90AB1, HSP90B, HSPC2, HSPCB
Domain Architecture
Description	Heat shock protein HSP 90-beta (HSP 84) (HSP 90).

CHD4_HUMAN
NC score	0.002495 (rank : 124)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	116	Target Neighborhood Hits	365	Shared Neighborhood Hits	5
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
NC score	0.002486 (rank : 125)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	116	Target Neighborhood Hits	408	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

ZHX3_HUMAN
NC score	0.001231 (rank : 126)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	116	Target Neighborhood Hits	331	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H4I2, O43145	Gene names	ZHX3, KIAA0395, TIX1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

DHX29_MOUSE
NC score	0.001191 (rank : 127)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	116	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9	Gene names	Dhx29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29).

OTX2_MOUSE
NC score	0.001041 (rank : 128)	θ value	4.03905 (rank : 92)
Query Neighborhood Hits	116	Target Neighborhood Hits	345	Shared Neighborhood Hits	5
SwissProt Accessions	P80206	Gene names	Otx2, Otx-2
Domain Architecture
Description	Homeobox protein OTX2.

OTX2_HUMAN
NC score	0.001000 (rank : 129)	θ value	4.03905 (rank : 91)
Query Neighborhood Hits	116	Target Neighborhood Hits	341	Shared Neighborhood Hits	3
SwissProt Accessions	P32243, Q6GTV3, Q9HAW3, Q9P2R1	Gene names	OTX2
Domain Architecture
Description	Homeobox protein OTX2.

HRH1_HUMAN
NC score	-0.001328 (rank : 130)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	116	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	P35367	Gene names	HRH1
Domain Architecture
Description	Histamine H1 receptor.

WNK4_HUMAN
NC score	-0.002637 (rank : 131)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	116	Target Neighborhood Hits	1043	Shared Neighborhood Hits	9
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

SIP1_MOUSE
NC score	-0.002843 (rank : 132)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	116	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

SIP1_HUMAN
NC score	-0.003206 (rank : 133)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	116	Target Neighborhood Hits	832	Shared Neighborhood Hits	5
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

ZN445_HUMAN
NC score	-0.004111 (rank : 134)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	116	Target Neighborhood Hits	764	Shared Neighborhood Hits	5
SwissProt Accessions	P59923	Gene names	ZNF445, ZNF168
Domain Architecture
Description	Zinc finger protein 445.

ZFP28_HUMAN
NC score	-0.004118 (rank : 135)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	116	Target Neighborhood Hits	843	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NHY6, Q9BY30, Q9P2B6	Gene names	ZFP28, KIAA1431
Domain Architecture
Description	Zinc finger protein 28 homolog (Zfp-28) (Krueppel-like zinc finger factor X6).

M3K13_HUMAN
NC score	-0.004701 (rank : 136)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	116	Target Neighborhood Hits	911	Shared Neighborhood Hits	3
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).