Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : TPTE2_HUMAN

For an explanation of this page, click here

TPTE2_HUMAN
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TPTE2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

TPTE_HUMAN
θ value	0 (rank : 2)	NC score	0.994589 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	53	Shared Neighborhood Hits	50
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

PTEN_HUMAN
θ value	7.24236e-58 (rank : 3)	NC score	0.872034 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	72	Shared Neighborhood Hits	31
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	7.24236e-58 (rank : 4)	NC score	0.872031 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	73	Shared Neighborhood Hits	31
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

GAK_HUMAN
θ value	1.02001e-27 (rank : 5)	NC score	0.247651 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	1028	Shared Neighborhood Hits	10
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_MOUSE
θ value	2.51237e-26 (rank : 6)	NC score	0.252498 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	964	Shared Neighborhood Hits	11
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

TENS1_HUMAN
θ value	2.77775e-25 (rank : 7)	NC score	0.596186 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	400	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

AUXI_HUMAN
θ value	6.40375e-22 (rank : 8)	NC score	0.674287 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	99	Shared Neighborhood Hits	10
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

AUXI_MOUSE
θ value	8.36355e-22 (rank : 9)	NC score	0.670803 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TZ3, Q6P2K9, Q8C7L9	Gene names	Dnajc6, Kiaa0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

CAC1I_HUMAN
θ value	3.19293e-05 (rank : 10)	NC score	0.192140 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	138	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_HUMAN
θ value	9.29e-05 (rank : 11)	NC score	0.191240 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1H_MOUSE
θ value	9.29e-05 (rank : 12)	NC score	0.192249 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	230	Shared Neighborhood Hits	27
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CC14B_HUMAN
θ value	0.00298849 (rank : 13)	NC score	0.178489 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	114	Shared Neighborhood Hits	32
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

PTPRB_HUMAN
θ value	0.00869519 (rank : 14)	NC score	0.074008 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

DUS11_HUMAN
θ value	0.0193708 (rank : 15)	NC score	0.183673 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	37	Shared Neighborhood Hits	19
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

CAC1G_HUMAN
θ value	0.0431538 (rank : 16)	NC score	0.170256 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	587	Shared Neighborhood Hits	27
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CC14B_MOUSE
θ value	0.0431538 (rank : 17)	NC score	0.155141 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

SCN3A_HUMAN
θ value	0.0563607 (rank : 18)	NC score	0.146835 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	115	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
θ value	0.0961366 (rank : 19)	NC score	0.146215 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	133	Shared Neighborhood Hits	26
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

CAC1A_MOUSE
θ value	0.125558 (rank : 20)	NC score	0.143095 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CC14A_HUMAN
θ value	0.125558 (rank : 21)	NC score	0.156648 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	133	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_MOUSE
θ value	0.125558 (rank : 22)	NC score	0.160840 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	117	Shared Neighborhood Hits	31
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CAC1E_HUMAN
θ value	0.163984 (rank : 23)	NC score	0.143716 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	148	Shared Neighborhood Hits	27
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	0.163984 (rank : 24)	NC score	0.143630 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	167	Shared Neighborhood Hits	26
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

DUS11_MOUSE
θ value	0.21417 (rank : 25)	NC score	0.159410 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

PTPRJ_HUMAN
θ value	0.21417 (rank : 26)	NC score	0.060519 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	207	Shared Neighborhood Hits	29
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

SCN2A_HUMAN
θ value	0.21417 (rank : 27)	NC score	0.140439 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

CAC1A_HUMAN
θ value	0.279714 (rank : 28)	NC score	0.140682 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	387	Shared Neighborhood Hits	26
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SCN1A_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.139556 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

PTPRJ_MOUSE
θ value	0.365318 (rank : 30)	NC score	0.058740 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

SC11A_MOUSE
θ value	0.365318 (rank : 31)	NC score	0.141193 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN5A_HUMAN
θ value	0.365318 (rank : 32)	NC score	0.140357 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	145	Shared Neighborhood Hits	26
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN9A_HUMAN
θ value	0.365318 (rank : 33)	NC score	0.138354 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1C_HUMAN
θ value	0.47712 (rank : 34)	NC score	0.130599 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	158	Shared Neighborhood Hits	26
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PTPM1_MOUSE
θ value	0.47712 (rank : 35)	NC score	0.119314 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

SC10A_HUMAN
θ value	0.47712 (rank : 36)	NC score	0.137739 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

DUS23_MOUSE
θ value	0.62314 (rank : 37)	NC score	0.163871 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	94	Shared Neighborhood Hits	29
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

DIAP3_MOUSE
θ value	0.813845 (rank : 38)	NC score	0.025829 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z207	Gene names	Diaph3, Diap3
Domain Architecture
Description	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2).

PTPM1_HUMAN
θ value	0.813845 (rank : 39)	NC score	0.112269 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	60	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

CAC1C_MOUSE
θ value	1.06291 (rank : 40)	NC score	0.130424 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	130	Shared Neighborhood Hits	26
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

PTN4_HUMAN
θ value	1.38821 (rank : 41)	NC score	0.034864 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	303	Shared Neighborhood Hits	25
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTPRA_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.059799 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	101	Shared Neighborhood Hits	29
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

MCE1_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.105268 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	34	Shared Neighborhood Hits	20
SwissProt Accessions	O60942, O43483, O60257, O60351	Gene names	RNGTT, CAP1A
Domain Architecture
Description	mRNA capping enzyme (HCE) (HCAP1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

PTPRA_MOUSE
θ value	1.81305 (rank : 44)	NC score	0.060925 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

S26A3_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.018950 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P40879	Gene names	SLC26A3, DRA
Domain Architecture
Description	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3).

MCE1_MOUSE
θ value	2.36792 (rank : 46)	NC score	0.101793 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O55236	Gene names	Rngtt, Cap1a
Domain Architecture
Description	mRNA capping enzyme (HCE) (MCE1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

PTPRU_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.044112 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	237	Shared Neighborhood Hits	26
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRV_MOUSE
θ value	2.36792 (rank : 48)	NC score	0.054711 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	25
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

SC10A_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.134844 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	107	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

DUS23_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.131298 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

CAC1S_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.128676 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

OR7D2_HUMAN
θ value	4.03905 (rank : 52)	NC score	-0.000353 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	809	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RA2, Q8N133	Gene names	OR7D2
Domain Architecture
Description	Olfactory receptor 7D2 (Olfactory receptor 19-4) (OR19-4) (HTPCRH03).

PTPRT_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.039630 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.039613 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	219	Shared Neighborhood Hits	22
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

TP4A3_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.082963 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	60	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

CAC1F_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.129135 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	141	Shared Neighborhood Hits	26
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

PTN12_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.049328 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	102	Shared Neighborhood Hits	21
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTPRO_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.046890 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	139	Shared Neighborhood Hits	23
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

S26A3_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.016249 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVC8	Gene names	Slc26a3, Dra
Domain Architecture
Description	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3).

ABC8B_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.003903 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K440, Q69ZY4, Q8BRQ1, Q9JL38	Gene names	Abca8b, Abca8, Kiaa0822
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 8-B.

PGBM_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.000025 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CAC1B_MOUSE
θ value	8.99809 (rank : 62)	NC score	0.127501 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	351	Shared Neighborhood Hits	25
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.127509 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.126259 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CD45_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.049155 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	243	Shared Neighborhood Hits	25
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.048218 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTN12_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.047770 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	123	Shared Neighborhood Hits	20
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN18_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.041946 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	134	Shared Neighborhood Hits	24
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

CAC1B_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.125491 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1D_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.123751 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	118	Shared Neighborhood Hits	24
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

PTN22_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.053911 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	21
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

SC11A_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.131288 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN7A_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.129866 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	135	Shared Neighborhood Hits	24
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN8A_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.127691 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	135	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.127647 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	136	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

TENS4_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.077659 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	214	Shared Neighborhood Hits	1
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.078327 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	225	Shared Neighborhood Hits	1
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TP4A1_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.075686 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.075686 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TP4A2_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.072294 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	19
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.072294 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	19
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

TP4A3_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.072776 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

Hits sorted by NC score

TPTE2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

TPTE_HUMAN
NC score	0.994589 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	53	Shared Neighborhood Hits	50
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

PTEN_HUMAN
NC score	0.872034 (rank : 3)	θ value	7.24236e-58 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	72	Shared Neighborhood Hits	31
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
NC score	0.872031 (rank : 4)	θ value	7.24236e-58 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	73	Shared Neighborhood Hits	31
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

AUXI_HUMAN
NC score	0.674287 (rank : 5)	θ value	6.40375e-22 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	99	Shared Neighborhood Hits	10
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

AUXI_MOUSE
NC score	0.670803 (rank : 6)	θ value	8.36355e-22 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TZ3, Q6P2K9, Q8C7L9	Gene names	Dnajc6, Kiaa0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

TENS1_HUMAN
NC score	0.596186 (rank : 7)	θ value	2.77775e-25 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	400	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

GAK_MOUSE
NC score	0.252498 (rank : 8)	θ value	2.51237e-26 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	964	Shared Neighborhood Hits	11
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_HUMAN
NC score	0.247651 (rank : 9)	θ value	1.02001e-27 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	1028	Shared Neighborhood Hits	10
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

CAC1H_MOUSE
NC score	0.192249 (rank : 10)	θ value	9.29e-05 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	230	Shared Neighborhood Hits	27
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1I_HUMAN
NC score	0.192140 (rank : 11)	θ value	3.19293e-05 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	138	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_HUMAN
NC score	0.191240 (rank : 12)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

DUS11_HUMAN
NC score	0.183673 (rank : 13)	θ value	0.0193708 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	37	Shared Neighborhood Hits	19
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

CC14B_HUMAN
NC score	0.178489 (rank : 14)	θ value	0.00298849 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	114	Shared Neighborhood Hits	32
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CAC1G_HUMAN
NC score	0.170256 (rank : 15)	θ value	0.0431538 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	587	Shared Neighborhood Hits	27
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

DUS23_MOUSE
NC score	0.163871 (rank : 16)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	94	Shared Neighborhood Hits	29
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

CC14A_MOUSE
NC score	0.160840 (rank : 17)	θ value	0.125558 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	117	Shared Neighborhood Hits	31
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

DUS11_MOUSE
NC score	0.159410 (rank : 18)	θ value	0.21417 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

CC14A_HUMAN
NC score	0.156648 (rank : 19)	θ value	0.125558 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	133	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14B_MOUSE
NC score	0.155141 (rank : 20)	θ value	0.0431538 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

SCN3A_HUMAN
NC score	0.146835 (rank : 21)	θ value	0.0563607 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	115	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
NC score	0.146215 (rank : 22)	θ value	0.0961366 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	133	Shared Neighborhood Hits	26
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

CAC1E_HUMAN
NC score	0.143716 (rank : 23)	θ value	0.163984 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	148	Shared Neighborhood Hits	27
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
NC score	0.143630 (rank : 24)	θ value	0.163984 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	167	Shared Neighborhood Hits	26
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1A_MOUSE
NC score	0.143095 (rank : 25)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SC11A_MOUSE
NC score	0.141193 (rank : 26)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

CAC1A_HUMAN
NC score	0.140682 (rank : 27)	θ value	0.279714 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	387	Shared Neighborhood Hits	26
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SCN2A_HUMAN
NC score	0.140439 (rank : 28)	θ value	0.21417 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN5A_HUMAN
NC score	0.140357 (rank : 29)	θ value	0.365318 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	145	Shared Neighborhood Hits	26
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN1A_HUMAN
NC score	0.139556 (rank : 30)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN9A_HUMAN
NC score	0.138354 (rank : 31)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	157	Shared Neighborhood Hits	26
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SC10A_HUMAN
NC score	0.137739 (rank : 32)	θ value	0.47712 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
NC score	0.134844 (rank : 33)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	107	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

DUS23_HUMAN
NC score	0.131298 (rank : 34)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

SC11A_HUMAN
NC score	0.131288 (rank : 35)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

CAC1C_HUMAN
NC score	0.130599 (rank : 36)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	158	Shared Neighborhood Hits	26
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1C_MOUSE
NC score	0.130424 (rank : 37)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	130	Shared Neighborhood Hits	26
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

SCN7A_HUMAN
NC score	0.129866 (rank : 38)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	135	Shared Neighborhood Hits	24
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

CAC1F_HUMAN
NC score	0.129135 (rank : 39)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	141	Shared Neighborhood Hits	26
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
NC score	0.128676 (rank : 40)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

SCN8A_HUMAN
NC score	0.127691 (rank : 41)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	135	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
NC score	0.127647 (rank : 42)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	136	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1F_MOUSE
NC score	0.127509 (rank : 43)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1B_MOUSE
NC score	0.127501 (rank : 44)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	351	Shared Neighborhood Hits	25
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_MOUSE
NC score	0.126259 (rank : 45)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_HUMAN
NC score	0.125491 (rank : 46)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1D_HUMAN
NC score	0.123751 (rank : 47)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	118	Shared Neighborhood Hits	24
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

PTPM1_MOUSE
NC score	0.119314 (rank : 48)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

PTPM1_HUMAN
NC score	0.112269 (rank : 49)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	60	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

MCE1_HUMAN
NC score	0.105268 (rank : 50)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	34	Shared Neighborhood Hits	20
SwissProt Accessions	O60942, O43483, O60257, O60351	Gene names	RNGTT, CAP1A
Domain Architecture
Description	mRNA capping enzyme (HCE) (HCAP1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

MCE1_MOUSE
NC score	0.101793 (rank : 51)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O55236	Gene names	Rngtt, Cap1a
Domain Architecture
Description	mRNA capping enzyme (HCE) (MCE1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

TP4A3_MOUSE
NC score	0.082963 (rank : 52)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	60	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

TENS4_MOUSE
NC score	0.078327 (rank : 53)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	225	Shared Neighborhood Hits	1
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TENS4_HUMAN
NC score	0.077659 (rank : 54)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	214	Shared Neighborhood Hits	1
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TP4A1_HUMAN
NC score	0.075686 (rank : 55)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
NC score	0.075686 (rank : 56)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

PTPRB_HUMAN
NC score	0.074008 (rank : 57)	θ value	0.00869519 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

TP4A3_HUMAN
NC score	0.072776 (rank : 58)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

TP4A2_HUMAN
NC score	0.072294 (rank : 59)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	19
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
NC score	0.072294 (rank : 60)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	19
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

PTPRA_MOUSE
NC score	0.060925 (rank : 61)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRJ_HUMAN
NC score	0.060519 (rank : 62)	θ value	0.21417 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	207	Shared Neighborhood Hits	29
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRA_HUMAN
NC score	0.059799 (rank : 63)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	101	Shared Neighborhood Hits	29
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRJ_MOUSE
NC score	0.058740 (rank : 64)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRV_MOUSE
NC score	0.054711 (rank : 65)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	25
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTN22_MOUSE
NC score	0.053911 (rank : 66)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	21
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN12_HUMAN
NC score	0.049328 (rank : 67)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	102	Shared Neighborhood Hits	21
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

CD45_HUMAN
NC score	0.049155 (rank : 68)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	243	Shared Neighborhood Hits	25
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
NC score	0.048218 (rank : 69)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTN12_MOUSE
NC score	0.047770 (rank : 70)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	123	Shared Neighborhood Hits	20
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTPRO_HUMAN
NC score	0.046890 (rank : 71)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	139	Shared Neighborhood Hits	23
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRU_HUMAN
NC score	0.044112 (rank : 72)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	237	Shared Neighborhood Hits	26
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTN18_MOUSE
NC score	0.041946 (rank : 73)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	134	Shared Neighborhood Hits	24
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTPRT_HUMAN
NC score	0.039630 (rank : 74)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
NC score	0.039613 (rank : 75)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	219	Shared Neighborhood Hits	22
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTN4_HUMAN
NC score	0.034864 (rank : 76)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	303	Shared Neighborhood Hits	25
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

DIAP3_MOUSE
NC score	0.025829 (rank : 77)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z207	Gene names	Diaph3, Diap3
Domain Architecture
Description	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2).

S26A3_HUMAN
NC score	0.018950 (rank : 78)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P40879	Gene names	SLC26A3, DRA
Domain Architecture
Description	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3).

S26A3_MOUSE
NC score	0.016249 (rank : 79)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVC8	Gene names	Slc26a3, Dra
Domain Architecture
Description	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3).

ABC8B_MOUSE
NC score	0.003903 (rank : 80)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K440, Q69ZY4, Q8BRQ1, Q9JL38	Gene names	Abca8b, Abca8, Kiaa0822
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 8-B.

PGBM_MOUSE
NC score	0.000025 (rank : 81)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

OR7D2_HUMAN
NC score	-0.000353 (rank : 82)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	809	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RA2, Q8N133	Gene names	OR7D2
Domain Architecture
Description	Olfactory receptor 7D2 (Olfactory receptor 19-4) (OR19-4) (HTPCRH03).