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Network neighborhood for query Sequence : TENS4_HUMAN

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TENS4_HUMAN
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TENS4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	214	Target Neighborhood Hits	214	Shared Neighborhood Hits	214
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	0 (rank : 2)	NC score	0.933118 (rank : 2)
Query Neighborhood Hits	214	Target Neighborhood Hits	225	Shared Neighborhood Hits	103
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TENS1_HUMAN
θ value	4.21644e-82 (rank : 3)	NC score	0.625696 (rank : 3)
Query Neighborhood Hits	214	Target Neighborhood Hits	400	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

CSK_MOUSE
θ value	0.000270298 (rank : 4)	NC score	0.107092 (rank : 68)
Query Neighborhood Hits	214	Target Neighborhood Hits	1009	Shared Neighborhood Hits	85
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
θ value	0.000461057 (rank : 5)	NC score	0.106152 (rank : 72)
Query Neighborhood Hits	214	Target Neighborhood Hits	1009	Shared Neighborhood Hits	85
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ATX2_HUMAN
θ value	0.000786445 (rank : 6)	NC score	0.115067 (rank : 61)
Query Neighborhood Hits	214	Target Neighborhood Hits	375	Shared Neighborhood Hits	28
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

RIN1_HUMAN
θ value	0.00102713 (rank : 7)	NC score	0.176156 (rank : 21)
Query Neighborhood Hits	214	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	Q13671, O15010, Q00427, Q96CC8	Gene names	RIN1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1) (Ras inhibitor JC99).

SLAP2_HUMAN
θ value	0.00228821 (rank : 8)	NC score	0.240988 (rank : 5)
Query Neighborhood Hits	214	Target Neighborhood Hits	139	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	0.00390308 (rank : 9)	NC score	0.241709 (rank : 4)
Query Neighborhood Hits	214	Target Neighborhood Hits	136	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

TXK_MOUSE
θ value	0.00390308 (rank : 10)	NC score	0.099174 (rank : 77)
Query Neighborhood Hits	214	Target Neighborhood Hits	980	Shared Neighborhood Hits	75
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

MAGE1_HUMAN
θ value	0.00509761 (rank : 11)	NC score	0.075005 (rank : 140)
Query Neighborhood Hits	214	Target Neighborhood Hits	1389	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

BTK_HUMAN
θ value	0.00869519 (rank : 12)	NC score	0.099024 (rank : 78)
Query Neighborhood Hits	214	Target Neighborhood Hits	1026	Shared Neighborhood Hits	74
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

P85B_HUMAN
θ value	0.0113563 (rank : 13)	NC score	0.185081 (rank : 15)
Query Neighborhood Hits	214	Target Neighborhood Hits	543	Shared Neighborhood Hits	82
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ATX2_MOUSE
θ value	0.0148317 (rank : 14)	NC score	0.110111 (rank : 66)
Query Neighborhood Hits	214	Target Neighborhood Hits	445	Shared Neighborhood Hits	37
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

GRB14_MOUSE
θ value	0.0148317 (rank : 15)	NC score	0.190927 (rank : 11)
Query Neighborhood Hits	214	Target Neighborhood Hits	149	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SOCS1_HUMAN
θ value	0.0148317 (rank : 16)	NC score	0.163974 (rank : 25)
Query Neighborhood Hits	214	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

BTK_MOUSE
θ value	0.0252991 (rank : 17)	NC score	0.097266 (rank : 83)
Query Neighborhood Hits	214	Target Neighborhood Hits	1017	Shared Neighborhood Hits	73
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

GRAP2_HUMAN
θ value	0.0252991 (rank : 18)	NC score	0.208656 (rank : 6)
Query Neighborhood Hits	214	Target Neighborhood Hits	304	Shared Neighborhood Hits	74
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	0.0252991 (rank : 19)	NC score	0.202339 (rank : 7)
Query Neighborhood Hits	214	Target Neighborhood Hits	297	Shared Neighborhood Hits	72
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

RIN1_MOUSE
θ value	0.0252991 (rank : 20)	NC score	0.143893 (rank : 41)
Query Neighborhood Hits	214	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

TXK_HUMAN
θ value	0.0252991 (rank : 21)	NC score	0.095557 (rank : 86)
Query Neighborhood Hits	214	Target Neighborhood Hits	971	Shared Neighborhood Hits	73
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

SOCS1_MOUSE
θ value	0.0330416 (rank : 22)	NC score	0.161696 (rank : 28)
Query Neighborhood Hits	214	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

BSN_MOUSE
θ value	0.0431538 (rank : 23)	NC score	0.098909 (rank : 79)
Query Neighborhood Hits	214	Target Neighborhood Hits	2057	Shared Neighborhood Hits	95
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CISH_MOUSE
θ value	0.0431538 (rank : 24)	NC score	0.155316 (rank : 33)
Query Neighborhood Hits	214	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

PCLO_MOUSE
θ value	0.0431538 (rank : 25)	NC score	0.073411 (rank : 143)
Query Neighborhood Hits	214	Target Neighborhood Hits	2275	Shared Neighborhood Hits	97
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PRG4_HUMAN
θ value	0.0431538 (rank : 26)	NC score	0.072162 (rank : 144)
Query Neighborhood Hits	214	Target Neighborhood Hits	764	Shared Neighborhood Hits	38
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

TEC_MOUSE
θ value	0.0431538 (rank : 27)	NC score	0.089884 (rank : 100)
Query Neighborhood Hits	214	Target Neighborhood Hits	1006	Shared Neighborhood Hits	65
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VAV2_HUMAN
θ value	0.0431538 (rank : 28)	NC score	0.134839 (rank : 49)
Query Neighborhood Hits	214	Target Neighborhood Hits	453	Shared Neighborhood Hits	74
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

NFH_MOUSE
θ value	0.0563607 (rank : 29)	NC score	0.053119 (rank : 225)
Query Neighborhood Hits	214	Target Neighborhood Hits	2247	Shared Neighborhood Hits	84
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TEC_HUMAN
θ value	0.0563607 (rank : 30)	NC score	0.090910 (rank : 98)
Query Neighborhood Hits	214	Target Neighborhood Hits	1006	Shared Neighborhood Hits	69
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VAV2_MOUSE
θ value	0.0563607 (rank : 31)	NC score	0.132568 (rank : 50)
Query Neighborhood Hits	214	Target Neighborhood Hits	456	Shared Neighborhood Hits	73
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CRK_HUMAN
θ value	0.0736092 (rank : 32)	NC score	0.198320 (rank : 8)
Query Neighborhood Hits	214	Target Neighborhood Hits	308	Shared Neighborhood Hits	79
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0736092 (rank : 33)	NC score	0.195605 (rank : 9)
Query Neighborhood Hits	214	Target Neighborhood Hits	314	Shared Neighborhood Hits	79
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRB10_MOUSE
θ value	0.0736092 (rank : 34)	NC score	0.162685 (rank : 27)
Query Neighborhood Hits	214	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

MUC2_HUMAN
θ value	0.0736092 (rank : 35)	NC score	0.068931 (rank : 159)
Query Neighborhood Hits	214	Target Neighborhood Hits	906	Shared Neighborhood Hits	45
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MUC7_HUMAN
θ value	0.0736092 (rank : 36)	NC score	0.093448 (rank : 90)
Query Neighborhood Hits	214	Target Neighborhood Hits	538	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

GRB10_HUMAN
θ value	0.0961366 (rank : 37)	NC score	0.161544 (rank : 29)
Query Neighborhood Hits	214	Target Neighborhood Hits	147	Shared Neighborhood Hits	62
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

RIN2_MOUSE
θ value	0.0961366 (rank : 38)	NC score	0.112608 (rank : 63)
Query Neighborhood Hits	214	Target Neighborhood Hits	72	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

SH24A_MOUSE
θ value	0.0961366 (rank : 39)	NC score	0.154310 (rank : 35)
Query Neighborhood Hits	214	Target Neighborhood Hits	326	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SRMS_HUMAN
θ value	0.0961366 (rank : 40)	NC score	0.092621 (rank : 91)
Query Neighborhood Hits	214	Target Neighborhood Hits	946	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

DOT1L_HUMAN
θ value	0.125558 (rank : 41)	NC score	0.080287 (rank : 133)
Query Neighborhood Hits	214	Target Neighborhood Hits	660	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

PTN11_HUMAN
θ value	0.125558 (rank : 42)	NC score	0.119154 (rank : 57)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.125558 (rank : 43)	NC score	0.119168 (rank : 56)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

ARI5B_MOUSE
θ value	0.163984 (rank : 44)	NC score	0.049217 (rank : 251)
Query Neighborhood Hits	214	Target Neighborhood Hits	158	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BM75, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4	Gene names	Arid5b, Desrt, Mrf2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (MRF1-like) (Modulator recognition factor protein 2) (MRF-2) (Developmentally and sexually retarded with transient immune abnormalities protein).

BMX_HUMAN
θ value	0.163984 (rank : 45)	NC score	0.083636 (rank : 127)
Query Neighborhood Hits	214	Target Neighborhood Hits	942	Shared Neighborhood Hits	73
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

GRB2_HUMAN
θ value	0.163984 (rank : 46)	NC score	0.188017 (rank : 13)
Query Neighborhood Hits	214	Target Neighborhood Hits	310	Shared Neighborhood Hits	74
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.163984 (rank : 47)	NC score	0.188072 (rank : 12)
Query Neighborhood Hits	214	Target Neighborhood Hits	312	Shared Neighborhood Hits	74
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

MBD5_HUMAN
θ value	0.163984 (rank : 48)	NC score	0.074596 (rank : 141)
Query Neighborhood Hits	214	Target Neighborhood Hits	176	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

RERE_MOUSE
θ value	0.163984 (rank : 49)	NC score	0.073437 (rank : 142)
Query Neighborhood Hits	214	Target Neighborhood Hits	785	Shared Neighborhood Hits	50
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TTLL4_MOUSE
θ value	0.163984 (rank : 50)	NC score	0.039549 (rank : 268)
Query Neighborhood Hits	214	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

CIC_MOUSE
θ value	0.21417 (rank : 51)	NC score	0.069083 (rank : 158)
Query Neighborhood Hits	214	Target Neighborhood Hits	742	Shared Neighborhood Hits	59
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CISH_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.139237 (rank : 45)
Query Neighborhood Hits	214	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

SSPO_MOUSE
θ value	0.21417 (rank : 53)	NC score	0.028289 (rank : 288)
Query Neighborhood Hits	214	Target Neighborhood Hits	800	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

TTC15_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.055764 (rank : 200)
Query Neighborhood Hits	214	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVT3, Q8WVW1, Q9Y395	Gene names	TTC15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

YLPM1_MOUSE
θ value	0.21417 (rank : 55)	NC score	0.066345 (rank : 172)
Query Neighborhood Hits	214	Target Neighborhood Hits	505	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ACD_HUMAN
θ value	0.279714 (rank : 56)	NC score	0.068659 (rank : 162)
Query Neighborhood Hits	214	Target Neighborhood Hits	143	Shared Neighborhood Hits	23
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

BMX_MOUSE
θ value	0.279714 (rank : 57)	NC score	0.083079 (rank : 128)
Query Neighborhood Hits	214	Target Neighborhood Hits	912	Shared Neighborhood Hits	73
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

HAIR_MOUSE
θ value	0.279714 (rank : 58)	NC score	0.048056 (rank : 252)
Query Neighborhood Hits	214	Target Neighborhood Hits	97	Shared Neighborhood Hits	9
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

HCN2_MOUSE
θ value	0.279714 (rank : 59)	NC score	0.027306 (rank : 290)
Query Neighborhood Hits	214	Target Neighborhood Hits	278	Shared Neighborhood Hits	25
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

MATK_HUMAN
θ value	0.279714 (rank : 60)	NC score	0.089668 (rank : 103)
Query Neighborhood Hits	214	Target Neighborhood Hits	954	Shared Neighborhood Hits	83
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MINT_MOUSE
θ value	0.279714 (rank : 61)	NC score	0.068274 (rank : 166)
Query Neighborhood Hits	214	Target Neighborhood Hits	1514	Shared Neighborhood Hits	73
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PITM1_HUMAN
θ value	0.279714 (rank : 62)	NC score	0.032043 (rank : 280)
Query Neighborhood Hits	214	Target Neighborhood Hits	129	Shared Neighborhood Hits	15
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

SEPT9_HUMAN
θ value	0.279714 (rank : 63)	NC score	0.047927 (rank : 254)
Query Neighborhood Hits	214	Target Neighborhood Hits	706	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

TARA_HUMAN
θ value	0.279714 (rank : 64)	NC score	0.066752 (rank : 168)
Query Neighborhood Hits	214	Target Neighborhood Hits	1626	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

BLK_MOUSE
θ value	0.365318 (rank : 65)	NC score	0.094428 (rank : 89)
Query Neighborhood Hits	214	Target Neighborhood Hits	992	Shared Neighborhood Hits	83
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CA103_MOUSE
θ value	0.365318 (rank : 66)	NC score	0.047770 (rank : 256)
Query Neighborhood Hits	214	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDD9, Q8C893	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf103 homolog.

LYN_MOUSE
θ value	0.365318 (rank : 67)	NC score	0.091632 (rank : 93)
Query Neighborhood Hits	214	Target Neighborhood Hits	1023	Shared Neighborhood Hits	80
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

P55G_HUMAN
θ value	0.365318 (rank : 68)	NC score	0.180589 (rank : 18)
Query Neighborhood Hits	214	Target Neighborhood Hits	451	Shared Neighborhood Hits	71
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	0.365318 (rank : 69)	NC score	0.187407 (rank : 14)
Query Neighborhood Hits	214	Target Neighborhood Hits	401	Shared Neighborhood Hits	69
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GRB7_HUMAN
θ value	0.47712 (rank : 70)	NC score	0.146056 (rank : 39)
Query Neighborhood Hits	214	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SC24C_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.077843 (rank : 138)
Query Neighborhood Hits	214	Target Neighborhood Hits	662	Shared Neighborhood Hits	59
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SHAN1_HUMAN
θ value	0.47712 (rank : 72)	NC score	0.042426 (rank : 262)
Query Neighborhood Hits	214	Target Neighborhood Hits	1041	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SRMS_MOUSE
θ value	0.47712 (rank : 73)	NC score	0.088582 (rank : 110)
Query Neighborhood Hits	214	Target Neighborhood Hits	964	Shared Neighborhood Hits	80
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

WASIP_MOUSE
θ value	0.47712 (rank : 74)	NC score	0.070903 (rank : 149)
Query Neighborhood Hits	214	Target Neighborhood Hits	392	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ZN598_MOUSE
θ value	0.47712 (rank : 75)	NC score	0.043661 (rank : 259)
Query Neighborhood Hits	214	Target Neighborhood Hits	255	Shared Neighborhood Hits	11
SwissProt Accessions	Q80YR4, Q6KAT0, Q8R3S1	Gene names	Znf598, Zfp598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

3BP1_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.039216 (rank : 269)
Query Neighborhood Hits	214	Target Neighborhood Hits	376	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

DNMT1_MOUSE
θ value	0.62314 (rank : 77)	NC score	0.037228 (rank : 271)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	8
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

GRAP_HUMAN
θ value	0.62314 (rank : 78)	NC score	0.184803 (rank : 17)
Query Neighborhood Hits	214	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

LYN_HUMAN
θ value	0.62314 (rank : 79)	NC score	0.090231 (rank : 99)
Query Neighborhood Hits	214	Target Neighborhood Hits	1022	Shared Neighborhood Hits	79
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MAST4_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.034067 (rank : 277)
Query Neighborhood Hits	214	Target Neighborhood Hits	1804	Shared Neighborhood Hits	91
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NPAS4_MOUSE
θ value	0.62314 (rank : 81)	NC score	0.062548 (rank : 184)
Query Neighborhood Hits	214	Target Neighborhood Hits	245	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PRDM2_HUMAN
θ value	0.62314 (rank : 82)	NC score	0.019629 (rank : 307)
Query Neighborhood Hits	214	Target Neighborhood Hits	1135	Shared Neighborhood Hits	36
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

PTN6_MOUSE
θ value	0.62314 (rank : 83)	NC score	0.098049 (rank : 80)
Query Neighborhood Hits	214	Target Neighborhood Hits	225	Shared Neighborhood Hits	72
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RERE_HUMAN
θ value	0.62314 (rank : 84)	NC score	0.063078 (rank : 181)
Query Neighborhood Hits	214	Target Neighborhood Hits	779	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SPEG_HUMAN
θ value	0.62314 (rank : 85)	NC score	0.034577 (rank : 276)
Query Neighborhood Hits	214	Target Neighborhood Hits	1762	Shared Neighborhood Hits	78
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

GRAP_MOUSE
θ value	0.813845 (rank : 86)	NC score	0.184951 (rank : 16)
Query Neighborhood Hits	214	Target Neighborhood Hits	309	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

HSH2D_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.180199 (rank : 19)
Query Neighborhood Hits	214	Target Neighborhood Hits	124	Shared Neighborhood Hits	61
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ZN619_HUMAN
θ value	0.813845 (rank : 88)	NC score	-0.000609 (rank : 343)
Query Neighborhood Hits	214	Target Neighborhood Hits	749	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N2I2	Gene names	ZNF619
Domain Architecture	No domain graphic available
Description	Zinc finger protein 619.

BLK_HUMAN
θ value	1.06291 (rank : 89)	NC score	0.088847 (rank : 107)
Query Neighborhood Hits	214	Target Neighborhood Hits	994	Shared Neighborhood Hits	76
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

EFS_MOUSE
θ value	1.06291 (rank : 90)	NC score	0.062669 (rank : 183)
Query Neighborhood Hits	214	Target Neighborhood Hits	389	Shared Neighborhood Hits	58
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MATK_MOUSE
θ value	1.06291 (rank : 91)	NC score	0.087670 (rank : 116)
Query Neighborhood Hits	214	Target Neighborhood Hits	952	Shared Neighborhood Hits	84
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

P85B_MOUSE
θ value	1.06291 (rank : 92)	NC score	0.167522 (rank : 23)
Query Neighborhood Hits	214	Target Neighborhood Hits	519	Shared Neighborhood Hits	81
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PHC2_HUMAN
θ value	1.06291 (rank : 93)	NC score	0.041877 (rank : 264)
Query Neighborhood Hits	214	Target Neighborhood Hits	388	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

RIMB1_HUMAN
θ value	1.06291 (rank : 94)	NC score	0.043543 (rank : 260)
Query Neighborhood Hits	214	Target Neighborhood Hits	1479	Shared Neighborhood Hits	70
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SH24A_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.131067 (rank : 51)
Query Neighborhood Hits	214	Target Neighborhood Hits	455	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

UNC5A_HUMAN
θ value	1.06291 (rank : 96)	NC score	0.025777 (rank : 293)
Query Neighborhood Hits	214	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5A_MOUSE
θ value	1.06291 (rank : 97)	NC score	0.023799 (rank : 299)
Query Neighborhood Hits	214	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

CDN1C_HUMAN
θ value	1.38821 (rank : 98)	NC score	0.054725 (rank : 212)
Query Neighborhood Hits	214	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CIC_HUMAN
θ value	1.38821 (rank : 99)	NC score	0.062869 (rank : 182)
Query Neighborhood Hits	214	Target Neighborhood Hits	992	Shared Neighborhood Hits	72
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CS016_HUMAN
θ value	1.38821 (rank : 100)	NC score	0.095714 (rank : 85)
Query Neighborhood Hits	214	Target Neighborhood Hits	310	Shared Neighborhood Hits	29
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

NCK1_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.167110 (rank : 24)
Query Neighborhood Hits	214	Target Neighborhood Hits	312	Shared Neighborhood Hits	73
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SOCS3_HUMAN
θ value	1.38821 (rank : 102)	NC score	0.157383 (rank : 32)
Query Neighborhood Hits	214	Target Neighborhood Hits	77	Shared Neighborhood Hits	44
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	1.38821 (rank : 103)	NC score	0.160486 (rank : 31)
Query Neighborhood Hits	214	Target Neighborhood Hits	72	Shared Neighborhood Hits	44
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

TMPS9_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.006418 (rank : 337)
Query Neighborhood Hits	214	Target Neighborhood Hits	276	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

CRKL_MOUSE
θ value	1.81305 (rank : 105)	NC score	0.177279 (rank : 20)
Query Neighborhood Hits	214	Target Neighborhood Hits	307	Shared Neighborhood Hits	74
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

GRB14_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.152541 (rank : 37)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	61
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HAIR_HUMAN
θ value	1.81305 (rank : 107)	NC score	0.043042 (rank : 261)
Query Neighborhood Hits	214	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

LNK_MOUSE
θ value	1.81305 (rank : 108)	NC score	0.145442 (rank : 40)
Query Neighborhood Hits	214	Target Neighborhood Hits	132	Shared Neighborhood Hits	59
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

PDE3A_MOUSE
θ value	1.81305 (rank : 109)	NC score	0.018601 (rank : 309)
Query Neighborhood Hits	214	Target Neighborhood Hits	115	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

SNG4_MOUSE
θ value	1.81305 (rank : 110)	NC score	0.025659 (rank : 294)
Query Neighborhood Hits	214	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1L2, Q80ZT0, Q9DA94	Gene names	Syngr4
Domain Architecture
Description	Synaptogyrin-4.

TAF4_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.060322 (rank : 189)
Query Neighborhood Hits	214	Target Neighborhood Hits	687	Shared Neighborhood Hits	40
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TRI66_HUMAN
θ value	1.81305 (rank : 112)	NC score	0.043793 (rank : 258)
Query Neighborhood Hits	214	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ZF106_HUMAN
θ value	1.81305 (rank : 113)	NC score	0.017711 (rank : 310)
Query Neighborhood Hits	214	Target Neighborhood Hits	470	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

ABL2_HUMAN
θ value	2.36792 (rank : 114)	NC score	0.091317 (rank : 97)
Query Neighborhood Hits	214	Target Neighborhood Hits	1045	Shared Neighborhood Hits	89
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ATX7_MOUSE
θ value	2.36792 (rank : 115)	NC score	0.046692 (rank : 257)
Query Neighborhood Hits	214	Target Neighborhood Hits	328	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

CD248_MOUSE
θ value	2.36792 (rank : 116)	NC score	0.032786 (rank : 278)
Query Neighborhood Hits	214	Target Neighborhood Hits	578	Shared Neighborhood Hits	46
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CMTA2_MOUSE
θ value	2.36792 (rank : 117)	NC score	0.022623 (rank : 303)
Query Neighborhood Hits	214	Target Neighborhood Hits	216	Shared Neighborhood Hits	10
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

FGR_MOUSE
θ value	2.36792 (rank : 118)	NC score	0.096910 (rank : 84)
Query Neighborhood Hits	214	Target Neighborhood Hits	1069	Shared Neighborhood Hits	88
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MINT_HUMAN
θ value	2.36792 (rank : 119)	NC score	0.047822 (rank : 255)
Query Neighborhood Hits	214	Target Neighborhood Hits	1291	Shared Neighborhood Hits	50
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

P2RX2_HUMAN
θ value	2.36792 (rank : 120)	NC score	0.024867 (rank : 296)
Query Neighborhood Hits	214	Target Neighborhood Hits	110	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBL9, Q6V9R6, Q9NR37, Q9NR38, Q9UHD5, Q9UHD6, Q9UHD7, Q9Y637, Q9Y638	Gene names	P2RX2, P2X2
Domain Architecture
Description	P2X purinoceptor 2 (ATP receptor) (P2X2) (Purinergic receptor).

PELP1_MOUSE
θ value	2.36792 (rank : 121)	NC score	0.047972 (rank : 253)
Query Neighborhood Hits	214	Target Neighborhood Hits	709	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PININ_MOUSE
θ value	2.36792 (rank : 122)	NC score	0.029303 (rank : 287)
Query Neighborhood Hits	214	Target Neighborhood Hits	777	Shared Neighborhood Hits	18
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

SRRM2_MOUSE
θ value	2.36792 (rank : 123)	NC score	0.071626 (rank : 146)
Query Neighborhood Hits	214	Target Neighborhood Hits	1470	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TM108_MOUSE
θ value	2.36792 (rank : 124)	NC score	0.053538 (rank : 223)
Query Neighborhood Hits	214	Target Neighborhood Hits	336	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

DDR1_HUMAN
θ value	3.0926 (rank : 125)	NC score	0.054878 (rank : 211)
Query Neighborhood Hits	214	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

FARP2_HUMAN
θ value	3.0926 (rank : 126)	NC score	0.008017 (rank : 334)
Query Neighborhood Hits	214	Target Neighborhood Hits	240	Shared Neighborhood Hits	8
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FYN_HUMAN
θ value	3.0926 (rank : 127)	NC score	0.091627 (rank : 94)
Query Neighborhood Hits	214	Target Neighborhood Hits	1078	Shared Neighborhood Hits	86
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

HSH2D_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.191480 (rank : 10)
Query Neighborhood Hits	214	Target Neighborhood Hits	159	Shared Neighborhood Hits	71
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HXA3_MOUSE
θ value	3.0926 (rank : 129)	NC score	0.016509 (rank : 312)
Query Neighborhood Hits	214	Target Neighborhood Hits	558	Shared Neighborhood Hits	25
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

KCNKF_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.013455 (rank : 322)
Query Neighborhood Hits	214	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

LNK_HUMAN
θ value	3.0926 (rank : 131)	NC score	0.130897 (rank : 52)
Query Neighborhood Hits	214	Target Neighborhood Hits	151	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

NCK2_HUMAN
θ value	3.0926 (rank : 132)	NC score	0.162999 (rank : 26)
Query Neighborhood Hits	214	Target Neighborhood Hits	310	Shared Neighborhood Hits	79
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

P85A_HUMAN
θ value	3.0926 (rank : 133)	NC score	0.146660 (rank : 38)
Query Neighborhood Hits	214	Target Neighborhood Hits	479	Shared Neighborhood Hits	69
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	3.0926 (rank : 134)	NC score	0.153917 (rank : 36)
Query Neighborhood Hits	214	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PLCG1_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.137786 (rank : 46)
Query Neighborhood Hits	214	Target Neighborhood Hits	293	Shared Neighborhood Hits	75
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	3.0926 (rank : 136)	NC score	0.136962 (rank : 47)
Query Neighborhood Hits	214	Target Neighborhood Hits	314	Shared Neighborhood Hits	75
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PSB2_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.035878 (rank : 274)
Query Neighborhood Hits	214	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P49721, P31145	Gene names	PSMB2
Domain Architecture
Description	Proteasome subunit beta type 2 (EC 3.4.25.1) (Proteasome component C7- I) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I).

PSB2_MOUSE
θ value	3.0926 (rank : 138)	NC score	0.035811 (rank : 275)
Query Neighborhood Hits	214	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1P3	Gene names	Psmb2
Domain Architecture
Description	Proteasome subunit beta type 2 (EC 3.4.25.1) (Proteasome component C7- I) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I).

PTN6_HUMAN
θ value	3.0926 (rank : 139)	NC score	0.089107 (rank : 105)
Query Neighborhood Hits	214	Target Neighborhood Hits	234	Shared Neighborhood Hits	69
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SOX9_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.016330 (rank : 314)
Query Neighborhood Hits	214	Target Neighborhood Hits	210	Shared Neighborhood Hits	16
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

ENAH_MOUSE
θ value	4.03905 (rank : 141)	NC score	0.049652 (rank : 250)
Query Neighborhood Hits	214	Target Neighborhood Hits	919	Shared Neighborhood Hits	49
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

K0056_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.025489 (rank : 295)
Query Neighborhood Hits	214	Target Neighborhood Hits	107	Shared Neighborhood Hits	16
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

LCK_HUMAN
θ value	4.03905 (rank : 143)	NC score	0.086898 (rank : 117)
Query Neighborhood Hits	214	Target Neighborhood Hits	987	Shared Neighborhood Hits	75
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	4.03905 (rank : 144)	NC score	0.085828 (rank : 121)
Query Neighborhood Hits	214	Target Neighborhood Hits	981	Shared Neighborhood Hits	75
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PHLB1_HUMAN
θ value	4.03905 (rank : 145)	NC score	0.030811 (rank : 283)
Query Neighborhood Hits	214	Target Neighborhood Hits	1038	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PO6F2_HUMAN
θ value	4.03905 (rank : 146)	NC score	0.022812 (rank : 302)
Query Neighborhood Hits	214	Target Neighborhood Hits	618	Shared Neighborhood Hits	31
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

SMAD5_MOUSE
θ value	4.03905 (rank : 147)	NC score	0.016453 (rank : 313)
Query Neighborhood Hits	214	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

CHIO_HUMAN
θ value	5.27518 (rank : 148)	NC score	0.057351 (rank : 196)
Query Neighborhood Hits	214	Target Neighborhood Hits	220	Shared Neighborhood Hits	50
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CRKL_HUMAN
θ value	5.27518 (rank : 149)	NC score	0.173062 (rank : 22)
Query Neighborhood Hits	214	Target Neighborhood Hits	313	Shared Neighborhood Hits	74
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DDR1_MOUSE
θ value	5.27518 (rank : 150)	NC score	0.054053 (rank : 219)
Query Neighborhood Hits	214	Target Neighborhood Hits	818	Shared Neighborhood Hits	35
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DIDO1_HUMAN
θ value	5.27518 (rank : 151)	NC score	0.036427 (rank : 272)
Query Neighborhood Hits	214	Target Neighborhood Hits	960	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

GGN_MOUSE
θ value	5.27518 (rank : 152)	NC score	0.041021 (rank : 265)
Query Neighborhood Hits	214	Target Neighborhood Hits	311	Shared Neighborhood Hits	29
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

HXA3_HUMAN
θ value	5.27518 (rank : 153)	NC score	0.014685 (rank : 318)
Query Neighborhood Hits	214	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

MILK2_HUMAN
θ value	5.27518 (rank : 154)	NC score	0.040559 (rank : 266)
Query Neighborhood Hits	214	Target Neighborhood Hits	457	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

PARM1_HUMAN
θ value	5.27518 (rank : 155)	NC score	0.036283 (rank : 273)
Query Neighborhood Hits	214	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UWI2, Q96DV8, Q9Y4S1	Gene names	ames=UNQ1879/PRO4322
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

RIN2_HUMAN
θ value	5.27518 (rank : 156)	NC score	0.086791 (rank : 118)
Query Neighborhood Hits	214	Target Neighborhood Hits	50	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WYP3, Q00425, Q5TFT8, Q9BQL3, Q9H071	Gene names	RIN2, RASSF4
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2) (Ras inhibitor JC265) (Ras association domain family 4).

SFPQ_MOUSE
θ value	5.27518 (rank : 157)	NC score	0.029767 (rank : 285)
Query Neighborhood Hits	214	Target Neighborhood Hits	958	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SIAH2_MOUSE
θ value	5.27518 (rank : 158)	NC score	0.013710 (rank : 320)
Query Neighborhood Hits	214	Target Neighborhood Hits	101	Shared Neighborhood Hits	7
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

SLAP1_HUMAN
θ value	5.27518 (rank : 159)	NC score	0.161170 (rank : 30)
Query Neighborhood Hits	214	Target Neighborhood Hits	113	Shared Neighborhood Hits	64
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SMAD5_HUMAN
θ value	5.27518 (rank : 160)	NC score	0.015804 (rank : 317)
Query Neighborhood Hits	214	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

SN1L2_HUMAN
θ value	5.27518 (rank : 161)	NC score	0.029361 (rank : 286)
Query Neighborhood Hits	214	Target Neighborhood Hits	964	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SP7_MOUSE
θ value	5.27518 (rank : 162)	NC score	0.003275 (rank : 341)
Query Neighborhood Hits	214	Target Neighborhood Hits	756	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VI67, Q8C5R3, Q8C6A7	Gene names	Sp7, Osx
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix) (C22).

SREC2_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.012367 (rank : 324)
Query Neighborhood Hits	214	Target Neighborhood Hits	645	Shared Neighborhood Hits	19
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

ZBP1_HUMAN
θ value	5.27518 (rank : 164)	NC score	0.022915 (rank : 301)
Query Neighborhood Hits	214	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

CEP68_MOUSE
θ value	6.88961 (rank : 165)	NC score	0.016205 (rank : 315)
Query Neighborhood Hits	214	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

IRTF_HUMAN
θ value	6.88961 (rank : 166)	NC score	0.010061 (rank : 329)
Query Neighborhood Hits	214	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q00978	Gene names	ISGF3G, IRF9
Domain Architecture
Description	Transcriptional regulator ISGF3 subunit gamma (Interferon regulatory factor 9) (IRF-9) (IFN-alpha-responsive transcription factor subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF3 p48 subunit) (ISGF- 3 gamma).

KCNH3_MOUSE
θ value	6.88961 (rank : 167)	NC score	0.013679 (rank : 321)
Query Neighborhood Hits	214	Target Neighborhood Hits	133	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

LPP_MOUSE
θ value	6.88961 (rank : 168)	NC score	0.010902 (rank : 326)
Query Neighborhood Hits	214	Target Neighborhood Hits	247	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

LRSM1_MOUSE
θ value	6.88961 (rank : 169)	NC score	0.005207 (rank : 339)
Query Neighborhood Hits	214	Target Neighborhood Hits	874	Shared Neighborhood Hits	14
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MNT_MOUSE
θ value	6.88961 (rank : 170)	NC score	0.051769 (rank : 236)
Query Neighborhood Hits	214	Target Neighborhood Hits	432	Shared Neighborhood Hits	30
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYPN_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.010002 (rank : 330)
Query Neighborhood Hits	214	Target Neighborhood Hits	421	Shared Neighborhood Hits	17
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NCOA6_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.068730 (rank : 160)
Query Neighborhood Hits	214	Target Neighborhood Hits	1202	Shared Neighborhood Hits	86
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PCLO_HUMAN
θ value	6.88961 (rank : 173)	NC score	0.063359 (rank : 179)
Query Neighborhood Hits	214	Target Neighborhood Hits	2046	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PININ_HUMAN
θ value	6.88961 (rank : 174)	NC score	0.026531 (rank : 291)
Query Neighborhood Hits	214	Target Neighborhood Hits	753	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PKN3_MOUSE
θ value	6.88961 (rank : 175)	NC score	0.024091 (rank : 298)
Query Neighborhood Hits	214	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

SALL3_HUMAN
θ value	6.88961 (rank : 176)	NC score	0.006766 (rank : 336)
Query Neighborhood Hits	214	Target Neighborhood Hits	1066	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

SFR15_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.032539 (rank : 279)
Query Neighborhood Hits	214	Target Neighborhood Hits	368	Shared Neighborhood Hits	23
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SHE_MOUSE
θ value	6.88961 (rank : 178)	NC score	0.141361 (rank : 42)
Query Neighborhood Hits	214	Target Neighborhood Hits	169	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SMAD9_MOUSE
θ value	6.88961 (rank : 179)	NC score	0.015862 (rank : 316)
Query Neighborhood Hits	214	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JIW5, Q8CFF9	Gene names	Smad9, Madh8, Madh9, Smad8
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Smad8).

SMCA2_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.013965 (rank : 319)
Query Neighborhood Hits	214	Target Neighborhood Hits	503	Shared Neighborhood Hits	25
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SO2B1_HUMAN
θ value	6.88961 (rank : 181)	NC score	0.006247 (rank : 338)
Query Neighborhood Hits	214	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	O94956, Q9H2Z0, Q9UFU1	Gene names	SLCO2B1, KIAA0880, OATPB, SLC21A9
Domain Architecture
Description	Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9) (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2).

STK6_MOUSE
θ value	6.88961 (rank : 182)	NC score	0.024506 (rank : 297)
Query Neighborhood Hits	214	Target Neighborhood Hits	886	Shared Neighborhood Hits	36
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TOR3A_MOUSE
θ value	6.88961 (rank : 183)	NC score	0.010452 (rank : 328)
Query Neighborhood Hits	214	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER38, Q3T9Q6, Q3TDA9, Q3U5X1, Q3U8F2, Q9CR17, Q9CU67	Gene names	Tor3a, Adir
Domain Architecture	No domain graphic available
Description	Torsin-3A precursor (Torsin family 3 member A) (ATP-dependent interferon-responsive protein).

WASIP_HUMAN
θ value	6.88961 (rank : 184)	NC score	0.057132 (rank : 197)
Query Neighborhood Hits	214	Target Neighborhood Hits	458	Shared Neighborhood Hits	34
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WBS14_HUMAN
θ value	6.88961 (rank : 185)	NC score	0.027842 (rank : 289)
Query Neighborhood Hits	214	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

ZBTB4_HUMAN
θ value	6.88961 (rank : 186)	NC score	0.011804 (rank : 325)
Query Neighborhood Hits	214	Target Neighborhood Hits	926	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

ZN319_MOUSE
θ value	6.88961 (rank : 187)	NC score	-0.001225 (rank : 344)
Query Neighborhood Hits	214	Target Neighborhood Hits	762	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERR8	Gene names	Znf319, Zfp319
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ABLM3_MOUSE
θ value	8.99809 (rank : 188)	NC score	0.003683 (rank : 340)
Query Neighborhood Hits	214	Target Neighborhood Hits	294	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZX8, Q52KR1, Q6PAI7	Gene names	Ablim3, Kiaa0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

ALEX_HUMAN
θ value	8.99809 (rank : 189)	NC score	0.061647 (rank : 186)
Query Neighborhood Hits	214	Target Neighborhood Hits	361	Shared Neighborhood Hits	37
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

BLNK_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.071823 (rank : 145)
Query Neighborhood Hits	214	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CBL_HUMAN
θ value	8.99809 (rank : 191)	NC score	0.016905 (rank : 311)
Query Neighborhood Hits	214	Target Neighborhood Hits	353	Shared Neighborhood Hits	26
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CHD4_HUMAN
θ value	8.99809 (rank : 192)	NC score	0.008657 (rank : 333)
Query Neighborhood Hits	214	Target Neighborhood Hits	365	Shared Neighborhood Hits	10
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	8.99809 (rank : 193)	NC score	0.010871 (rank : 327)
Query Neighborhood Hits	214	Target Neighborhood Hits	408	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CTND2_HUMAN
θ value	8.99809 (rank : 194)	NC score	0.031564 (rank : 281)
Query Neighborhood Hits	214	Target Neighborhood Hits	333	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

GORS2_HUMAN
θ value	8.99809 (rank : 195)	NC score	0.021145 (rank : 304)
Query Neighborhood Hits	214	Target Neighborhood Hits	82	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

HCK_HUMAN
θ value	8.99809 (rank : 196)	NC score	0.089034 (rank : 106)
Query Neighborhood Hits	214	Target Neighborhood Hits	1035	Shared Neighborhood Hits	81
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KSR1_MOUSE
θ value	8.99809 (rank : 197)	NC score	0.042062 (rank : 263)
Query Neighborhood Hits	214	Target Neighborhood Hits	870	Shared Neighborhood Hits	36
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MAML1_HUMAN
θ value	8.99809 (rank : 198)	NC score	0.023013 (rank : 300)
Query Neighborhood Hits	214	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MEF2B_MOUSE
θ value	8.99809 (rank : 199)	NC score	0.020928 (rank : 305)
Query Neighborhood Hits	214	Target Neighborhood Hits	218	Shared Neighborhood Hits	20
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

MLL4_HUMAN
θ value	8.99809 (rank : 200)	NC score	0.026496 (rank : 292)
Query Neighborhood Hits	214	Target Neighborhood Hits	722	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

OSBL5_HUMAN
θ value	8.99809 (rank : 201)	NC score	0.007391 (rank : 335)
Query Neighborhood Hits	214	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

PO2F2_HUMAN
θ value	8.99809 (rank : 202)	NC score	0.009950 (rank : 331)
Query Neighborhood Hits	214	Target Neighborhood Hits	379	Shared Neighborhood Hits	16
SwissProt Accessions	P09086, Q16648, Q9BRS4	Gene names	POU2F2, OCT2, OTF2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).

PO2F2_MOUSE
θ value	8.99809 (rank : 203)	NC score	0.009802 (rank : 332)
Query Neighborhood Hits	214	Target Neighborhood Hits	353	Shared Neighborhood Hits	14
SwissProt Accessions	Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q61995, Q61996, Q64245	Gene names	Pou2f2, Oct2, Otf2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).

PO6F2_MOUSE
θ value	8.99809 (rank : 204)	NC score	0.018649 (rank : 308)
Query Neighborhood Hits	214	Target Neighborhood Hits	639	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PRR12_HUMAN
θ value	8.99809 (rank : 205)	NC score	0.038308 (rank : 270)
Query Neighborhood Hits	214	Target Neighborhood Hits	460	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

R4RL1_HUMAN
θ value	8.99809 (rank : 206)	NC score	0.001191 (rank : 342)
Query Neighborhood Hits	214	Target Neighborhood Hits	240	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

SETBP_MOUSE
θ value	8.99809 (rank : 207)	NC score	0.030498 (rank : 284)
Query Neighborhood Hits	214	Target Neighborhood Hits	352	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SF3A1_HUMAN
θ value	8.99809 (rank : 208)	NC score	0.019672 (rank : 306)
Query Neighborhood Hits	214	Target Neighborhood Hits	199	Shared Neighborhood Hits	18
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

SH22A_MOUSE
θ value	8.99809 (rank : 209)	NC score	0.118016 (rank : 58)
Query Neighborhood Hits	214	Target Neighborhood Hits	179	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SRRM1_MOUSE
θ value	8.99809 (rank : 210)	NC score	0.056728 (rank : 199)
Query Neighborhood Hits	214	Target Neighborhood Hits	966	Shared Neighborhood Hits	54
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

T22D2_HUMAN
θ value	8.99809 (rank : 211)	NC score	0.040523 (rank : 267)
Query Neighborhood Hits	214	Target Neighborhood Hits	250	Shared Neighborhood Hits	24
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TISD_HUMAN
θ value	8.99809 (rank : 212)	NC score	0.012621 (rank : 323)
Query Neighborhood Hits	214	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

WASL_MOUSE
θ value	8.99809 (rank : 213)	NC score	0.031306 (rank : 282)
Query Neighborhood Hits	214	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ZN319_HUMAN
θ value	8.99809 (rank : 214)	NC score	-0.001440 (rank : 345)
Query Neighborhood Hits	214	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P2F9	Gene names	ZNF319, KIAA1388
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

AATK_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.054719 (rank : 213)
Query Neighborhood Hits	214	Target Neighborhood Hits	1243	Shared Neighborhood Hits	70
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.055129 (rank : 210)
Query Neighborhood Hits	214	Target Neighborhood Hits	942	Shared Neighborhood Hits	47
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

AB1IP_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.052552 (rank : 228)
Query Neighborhood Hits	214	Target Neighborhood Hits	213	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.055277 (rank : 209)
Query Neighborhood Hits	214	Target Neighborhood Hits	181	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ABL1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.088356 (rank : 113)
Query Neighborhood Hits	214	Target Neighborhood Hits	1220	Shared Neighborhood Hits	102
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.088690 (rank : 109)
Query Neighborhood Hits	214	Target Neighborhood Hits	1178	Shared Neighborhood Hits	100
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ACK1_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.055673 (rank : 202)
Query Neighborhood Hits	214	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.055689 (rank : 201)
Query Neighborhood Hits	214	Target Neighborhood Hits	1080	Shared Neighborhood Hits	67
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ALK_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.051412 (rank : 239)
Query Neighborhood Hits	214	Target Neighborhood Hits	795	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.051770 (rank : 235)
Query Neighborhood Hits	214	Target Neighborhood Hits	811	Shared Neighborhood Hits	36
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

APS_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.112359 (rank : 64)
Query Neighborhood Hits	214	Target Neighborhood Hits	162	Shared Neighborhood Hits	62
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.097858 (rank : 82)
Query Neighborhood Hits	214	Target Neighborhood Hits	134	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ATN1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.054244 (rank : 218)
Query Neighborhood Hits	214	Target Neighborhood Hits	676	Shared Neighborhood Hits	43
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

ATX2L_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.069743 (rank : 155)
Query Neighborhood Hits	214	Target Neighborhood Hits	443	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

ATX2L_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.070152 (rank : 153)
Query Neighborhood Hits	214	Target Neighborhood Hits	401	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

AUXI_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.068548 (rank : 164)
Query Neighborhood Hits	214	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

AUXI_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.068674 (rank : 161)
Query Neighborhood Hits	214	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TZ3, Q6P2K9, Q8C7L9	Gene names	Dnajc6, Kiaa0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

BCAR1_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.056930 (rank : 198)
Query Neighborhood Hits	214	Target Neighborhood Hits	554	Shared Neighborhood Hits	65
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR3_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.068300 (rank : 165)
Query Neighborhood Hits	214	Target Neighborhood Hits	129	Shared Neighborhood Hits	47
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.064481 (rank : 175)
Query Neighborhood Hits	214	Target Neighborhood Hits	127	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BLNK_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.083700 (rank : 126)
Query Neighborhood Hits	214	Target Neighborhood Hits	296	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BSN_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.066375 (rank : 171)
Query Neighborhood Hits	214	Target Neighborhood Hits	1537	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CBP_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.050984 (rank : 241)
Query Neighborhood Hits	214	Target Neighborhood Hits	1051	Shared Neighborhood Hits	67
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CD2AP_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.054442 (rank : 216)
Query Neighborhood Hits	214	Target Neighborhood Hits	315	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.051477 (rank : 238)
Query Neighborhood Hits	214	Target Neighborhood Hits	336	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CHIN_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.053433 (rank : 224)
Query Neighborhood Hits	214	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

DAPP1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.136418 (rank : 48)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.139625 (rank : 44)
Query Neighborhood Hits	214	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DNMBP_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.053579 (rank : 221)
Query Neighborhood Hits	214	Target Neighborhood Hits	413	Shared Neighborhood Hits	45
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EFS_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.054307 (rank : 217)
Query Neighborhood Hits	214	Target Neighborhood Hits	348	Shared Neighborhood Hits	49
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

FER_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.069261 (rank : 157)
Query Neighborhood Hits	214	Target Neighborhood Hits	1278	Shared Neighborhood Hits	84
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.055342 (rank : 207)
Query Neighborhood Hits	214	Target Neighborhood Hits	978	Shared Neighborhood Hits	58
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.053806 (rank : 220)
Query Neighborhood Hits	214	Target Neighborhood Hits	980	Shared Neighborhood Hits	57
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.089832 (rank : 101)
Query Neighborhood Hits	214	Target Neighborhood Hits	1067	Shared Neighborhood Hits	85
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FRK_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.082943 (rank : 129)
Query Neighborhood Hits	214	Target Neighborhood Hits	1058	Shared Neighborhood Hits	82
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.085666 (rank : 122)
Query Neighborhood Hits	214	Target Neighborhood Hits	1073	Shared Neighborhood Hits	82
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GAK_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.050207 (rank : 246)
Query Neighborhood Hits	214	Target Neighborhood Hits	1028	Shared Neighborhood Hits	46
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GRB7_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.140144 (rank : 43)
Query Neighborhood Hits	214	Target Neighborhood Hits	157	Shared Neighborhood Hits	67
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GSCR1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.055325 (rank : 208)
Query Neighborhood Hits	214	Target Neighborhood Hits	674	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HCK_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.087674 (rank : 115)
Query Neighborhood Hits	214	Target Neighborhood Hits	1029	Shared Neighborhood Hits	75
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCLS1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.050540 (rank : 245)
Query Neighborhood Hits	214	Target Neighborhood Hits	358	Shared Neighborhood Hits	57
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ITK_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.084566 (rank : 124)
Query Neighborhood Hits	214	Target Neighborhood Hits	1016	Shared Neighborhood Hits	78
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.084603 (rank : 123)
Query Neighborhood Hits	214	Target Neighborhood Hits	985	Shared Neighborhood Hits	77
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KSYK_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.068652 (rank : 163)
Query Neighborhood Hits	214	Target Neighborhood Hits	901	Shared Neighborhood Hits	75
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.069349 (rank : 156)
Query Neighborhood Hits	214	Target Neighborhood Hits	944	Shared Neighborhood Hits	77
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LCP2_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.101836 (rank : 74)
Query Neighborhood Hits	214	Target Neighborhood Hits	531	Shared Neighborhood Hits	84
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.068055 (rank : 167)
Query Neighborhood Hits	214	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LTK_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.052131 (rank : 232)
Query Neighborhood Hits	214	Target Neighborhood Hits	774	Shared Neighborhood Hits	32
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.052138 (rank : 231)
Query Neighborhood Hits	214	Target Neighborhood Hits	770	Shared Neighborhood Hits	34
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MDC1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.059959 (rank : 191)
Query Neighborhood Hits	214	Target Neighborhood Hits	1446	Shared Neighborhood Hits	79
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.071526 (rank : 147)
Query Neighborhood Hits	214	Target Neighborhood Hits	998	Shared Neighborhood Hits	68
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MUC1_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.064105 (rank : 178)
Query Neighborhood Hits	214	Target Neighborhood Hits	975	Shared Neighborhood Hits	66
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NACAM_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.070429 (rank : 152)
Query Neighborhood Hits	214	Target Neighborhood Hits	1866	Shared Neighborhood Hits	93
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCF2_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.052225 (rank : 230)
Query Neighborhood Hits	214	Target Neighborhood Hits	229	Shared Neighborhood Hits	38
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCOA6_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.058751 (rank : 194)
Query Neighborhood Hits	214	Target Neighborhood Hits	1076	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NPHP1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.071167 (rank : 148)
Query Neighborhood Hits	214	Target Neighborhood Hits	288	Shared Neighborhood Hits	40
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.070431 (rank : 151)
Query Neighborhood Hits	214	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OGFR_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.055544 (rank : 206)
Query Neighborhood Hits	214	Target Neighborhood Hits	1582	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OSTF1_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.050795 (rank : 244)
Query Neighborhood Hits	214	Target Neighborhood Hits	466	Shared Neighborhood Hits	37
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PLCG2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.119437 (rank : 55)
Query Neighborhood Hits	214	Target Neighborhood Hits	280	Shared Neighborhood Hits	70
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.050164 (rank : 247)
Query Neighborhood Hits	214	Target Neighborhood Hits	389	Shared Neighborhood Hits	44
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PRRT3_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.069893 (rank : 154)
Query Neighborhood Hits	214	Target Neighborhood Hits	998	Shared Neighborhood Hits	71
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PTEN_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.091337 (rank : 96)
Query Neighborhood Hits	214	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.091338 (rank : 95)
Query Neighborhood Hits	214	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

PTK6_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.078030 (rank : 137)
Query Neighborhood Hits	214	Target Neighborhood Hits	1020	Shared Neighborhood Hits	77
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.078657 (rank : 136)
Query Neighborhood Hits	214	Target Neighborhood Hits	1026	Shared Neighborhood Hits	78
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RAPH1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.070602 (rank : 150)
Query Neighborhood Hits	214	Target Neighborhood Hits	593	Shared Neighborhood Hits	49
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.125680 (rank : 53)
Query Neighborhood Hits	214	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RGS3_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.060392 (rank : 188)
Query Neighborhood Hits	214	Target Neighborhood Hits	1621	Shared Neighborhood Hits	89
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RIN3_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.059928 (rank : 192)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIN3_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.057872 (rank : 195)
Query Neighborhood Hits	214	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RYK_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.051176 (rank : 240)
Query Neighborhood Hits	214	Target Neighborhood Hits	701	Shared Neighborhood Hits	32
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.050893 (rank : 243)
Query Neighborhood Hits	214	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SAPS1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.051719 (rank : 237)
Query Neighborhood Hits	214	Target Neighborhood Hits	704	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SELPL_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.060232 (rank : 190)
Query Neighborhood Hits	214	Target Neighborhood Hits	588	Shared Neighborhood Hits	53
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SH21A_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.092569 (rank : 92)
Query Neighborhood Hits	214	Target Neighborhood Hits	89	Shared Neighborhood Hits	44
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.099738 (rank : 76)
Query Neighborhood Hits	214	Target Neighborhood Hits	89	Shared Neighborhood Hits	46
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.122613 (rank : 54)
Query Neighborhood Hits	214	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.117206 (rank : 60)
Query Neighborhood Hits	214	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.088469 (rank : 111)
Query Neighborhood Hits	214	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH23A_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.063124 (rank : 180)
Query Neighborhood Hits	214	Target Neighborhood Hits	149	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH2D3_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.066733 (rank : 169)
Query Neighborhood Hits	214	Target Neighborhood Hits	188	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.065539 (rank : 173)
Query Neighborhood Hits	214	Target Neighborhood Hits	174	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.106434 (rank : 71)
Query Neighborhood Hits	214	Target Neighborhood Hits	141	Shared Neighborhood Hits	70
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.110966 (rank : 65)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	70
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.087903 (rank : 114)
Query Neighborhood Hits	214	Target Neighborhood Hits	170	Shared Neighborhood Hits	64
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.088733 (rank : 108)
Query Neighborhood Hits	214	Target Neighborhood Hits	180	Shared Neighborhood Hits	70
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.080790 (rank : 132)
Query Neighborhood Hits	214	Target Neighborhood Hits	170	Shared Neighborhood Hits	63
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.081547 (rank : 131)
Query Neighborhood Hits	214	Target Neighborhood Hits	144	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.083953 (rank : 125)
Query Neighborhood Hits	214	Target Neighborhood Hits	155	Shared Neighborhood Hits	60
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.095187 (rank : 87)
Query Neighborhood Hits	214	Target Neighborhood Hits	151	Shared Neighborhood Hits	61
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.097865 (rank : 81)
Query Neighborhood Hits	214	Target Neighborhood Hits	204	Shared Neighborhood Hits	70
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.104304 (rank : 73)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	68
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.113815 (rank : 62)
Query Neighborhood Hits	214	Target Neighborhood Hits	164	Shared Neighborhood Hits	73
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.154815 (rank : 34)
Query Neighborhood Hits	214	Target Neighborhood Hits	117	Shared Neighborhood Hits	65
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SOCS2_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.106622 (rank : 69)
Query Neighborhood Hits	214	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.117419 (rank : 59)
Query Neighborhood Hits	214	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.079884 (rank : 134)
Query Neighborhood Hits	214	Target Neighborhood Hits	126	Shared Neighborhood Hits	49
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.079665 (rank : 135)
Query Neighborhood Hits	214	Target Neighborhood Hits	146	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.089692 (rank : 102)
Query Neighborhood Hits	214	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SON_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.052414 (rank : 229)
Query Neighborhood Hits	214	Target Neighborhood Hits	1568	Shared Neighborhood Hits	89
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPN90_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.053046 (rank : 226)
Query Neighborhood Hits	214	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.050076 (rank : 248)
Query Neighborhood Hits	214	Target Neighborhood Hits	157	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.064423 (rank : 176)
Query Neighborhood Hits	214	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.064294 (rank : 177)
Query Neighborhood Hits	214	Target Neighborhood Hits	409	Shared Neighborhood Hits	59
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.088422 (rank : 112)
Query Neighborhood Hits	214	Target Neighborhood Hits	1058	Shared Neighborhood Hits	82
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.089470 (rank : 104)
Query Neighborhood Hits	214	Target Neighborhood Hits	1033	Shared Neighborhood Hits	82
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRRM2_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.060790 (rank : 187)
Query Neighborhood Hits	214	Target Neighborhood Hits	1296	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STAC3_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.050975 (rank : 242)
Query Neighborhood Hits	214	Target Neighborhood Hits	228	Shared Neighborhood Hits	36
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.050056 (rank : 249)
Query Neighborhood Hits	214	Target Neighborhood Hits	232	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.053563 (rank : 222)
Query Neighborhood Hits	214	Target Neighborhood Hits	276	Shared Neighborhood Hits	38
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.055611 (rank : 205)
Query Neighborhood Hits	214	Target Neighborhood Hits	268	Shared Neighborhood Hits	36
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.054606 (rank : 215)
Query Neighborhood Hits	214	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.055627 (rank : 203)
Query Neighborhood Hits	214	Target Neighborhood Hits	273	Shared Neighborhood Hits	36
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.055617 (rank : 204)
Query Neighborhood Hits	214	Target Neighborhood Hits	288	Shared Neighborhood Hits	36
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.052070 (rank : 233)
Query Neighborhood Hits	214	Target Neighborhood Hits	285	Shared Neighborhood Hits	33
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STYK1_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.052815 (rank : 227)
Query Neighborhood Hits	214	Target Neighborhood Hits	786	Shared Neighborhood Hits	32
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.051816 (rank : 234)
Query Neighborhood Hits	214	Target Neighborhood Hits	779	Shared Neighborhood Hits	32
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TCGAP_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.054666 (rank : 214)
Query Neighborhood Hits	214	Target Neighborhood Hits	872	Shared Neighborhood Hits	81
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TPTE2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.077659 (rank : 139)
Query Neighborhood Hits	214	Target Neighborhood Hits	68	Shared Neighborhood Hits	1
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

TPTE_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.082569 (rank : 130)
Query Neighborhood Hits	214	Target Neighborhood Hits	53	Shared Neighborhood Hits	1
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

VAV3_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.107578 (rank : 67)
Query Neighborhood Hits	214	Target Neighborhood Hits	398	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.106558 (rank : 70)
Query Neighborhood Hits	214	Target Neighborhood Hits	404	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.101758 (rank : 75)
Query Neighborhood Hits	214	Target Neighborhood Hits	452	Shared Neighborhood Hits	68
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.094751 (rank : 88)
Query Neighborhood Hits	214	Target Neighborhood Hits	430	Shared Neighborhood Hits	65
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VINEX_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.059100 (rank : 193)
Query Neighborhood Hits	214	Target Neighborhood Hits	270	Shared Neighborhood Hits	46
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.061806 (rank : 185)
Query Neighborhood Hits	214	Target Neighborhood Hits	286	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YES_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.086281 (rank : 119)
Query Neighborhood Hits	214	Target Neighborhood Hits	1059	Shared Neighborhood Hits	77
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.086195 (rank : 120)
Query Neighborhood Hits	214	Target Neighborhood Hits	1052	Shared Neighborhood Hits	76
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.065517 (rank : 174)
Query Neighborhood Hits	214	Target Neighborhood Hits	893	Shared Neighborhood Hits	74
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.066584 (rank : 170)
Query Neighborhood Hits	214	Target Neighborhood Hits	905	Shared Neighborhood Hits	74
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

TENS4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	214	Target Neighborhood Hits	214	Shared Neighborhood Hits	214
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
NC score	0.933118 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	214	Target Neighborhood Hits	225	Shared Neighborhood Hits	103
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TENS1_HUMAN
NC score	0.625696 (rank : 3)	θ value	4.21644e-82 (rank : 3)
Query Neighborhood Hits	214	Target Neighborhood Hits	400	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

SLAP2_MOUSE
NC score	0.241709 (rank : 4)	θ value	0.00390308 (rank : 9)
Query Neighborhood Hits	214	Target Neighborhood Hits	136	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.240988 (rank : 5)	θ value	0.00228821 (rank : 8)
Query Neighborhood Hits	214	Target Neighborhood Hits	139	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

GRAP2_HUMAN
NC score	0.208656 (rank : 6)	θ value	0.0252991 (rank : 18)
Query Neighborhood Hits	214	Target Neighborhood Hits	304	Shared Neighborhood Hits	74
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.202339 (rank : 7)	θ value	0.0252991 (rank : 19)
Query Neighborhood Hits	214	Target Neighborhood Hits	297	Shared Neighborhood Hits	72
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CRK_HUMAN
NC score	0.198320 (rank : 8)	θ value	0.0736092 (rank : 32)
Query Neighborhood Hits	214	Target Neighborhood Hits	308	Shared Neighborhood Hits	79
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.195605 (rank : 9)	θ value	0.0736092 (rank : 33)
Query Neighborhood Hits	214	Target Neighborhood Hits	314	Shared Neighborhood Hits	79
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

HSH2D_HUMAN
NC score	0.191480 (rank : 10)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	214	Target Neighborhood Hits	159	Shared Neighborhood Hits	71
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

GRB14_MOUSE
NC score	0.190927 (rank : 11)	θ value	0.0148317 (rank : 15)
Query Neighborhood Hits	214	Target Neighborhood Hits	149	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_MOUSE
NC score	0.188072 (rank : 12)	θ value	0.163984 (rank : 47)
Query Neighborhood Hits	214	Target Neighborhood Hits	312	Shared Neighborhood Hits	74
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.188017 (rank : 13)	θ value	0.163984 (rank : 46)
Query Neighborhood Hits	214	Target Neighborhood Hits	310	Shared Neighborhood Hits	74
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

P55G_MOUSE
NC score	0.187407 (rank : 14)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	214	Target Neighborhood Hits	401	Shared Neighborhood Hits	69
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
NC score	0.185081 (rank : 15)	θ value	0.0113563 (rank : 13)
Query Neighborhood Hits	214	Target Neighborhood Hits	543	Shared Neighborhood Hits	82
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

GRAP_MOUSE
NC score	0.184951 (rank : 16)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	214	Target Neighborhood Hits	309	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.184803 (rank : 17)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	214	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

P55G_HUMAN
NC score	0.180589 (rank : 18)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	214	Target Neighborhood Hits	451	Shared Neighborhood Hits	71
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

HSH2D_MOUSE
NC score	0.180199 (rank : 19)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	214	Target Neighborhood Hits	124	Shared Neighborhood Hits	61
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

CRKL_MOUSE
NC score	0.177279 (rank : 20)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	214	Target Neighborhood Hits	307	Shared Neighborhood Hits	74
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

RIN1_HUMAN
NC score	0.176156 (rank : 21)	θ value	0.00102713 (rank : 7)
Query Neighborhood Hits	214	Target Neighborhood Hits	52	Shared Neighborhood Hits	14
SwissProt Accessions	Q13671, O15010, Q00427, Q96CC8	Gene names	RIN1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1) (Ras inhibitor JC99).

CRKL_HUMAN
NC score	0.173062 (rank : 22)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	214	Target Neighborhood Hits	313	Shared Neighborhood Hits	74
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

P85B_MOUSE
NC score	0.167522 (rank : 23)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	214	Target Neighborhood Hits	519	Shared Neighborhood Hits	81
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

NCK1_HUMAN
NC score	0.167110 (rank : 24)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	214	Target Neighborhood Hits	312	Shared Neighborhood Hits	73
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SOCS1_HUMAN
NC score	0.163974 (rank : 25)	θ value	0.0148317 (rank : 16)
Query Neighborhood Hits	214	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

NCK2_HUMAN
NC score	0.162999 (rank : 26)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	214	Target Neighborhood Hits	310	Shared Neighborhood Hits	79
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRB10_MOUSE
NC score	0.162685 (rank : 27)	θ value	0.0736092 (rank : 34)
Query Neighborhood Hits	214	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

SOCS1_MOUSE
NC score	0.161696 (rank : 28)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	214	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

GRB10_HUMAN
NC score	0.161544 (rank : 29)	θ value	0.0961366 (rank : 37)
Query Neighborhood Hits	214	Target Neighborhood Hits	147	Shared Neighborhood Hits	62
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

SLAP1_HUMAN
NC score	0.161170 (rank : 30)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	214	Target Neighborhood Hits	113	Shared Neighborhood Hits	64
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SOCS3_MOUSE
NC score	0.160486 (rank : 31)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	214	Target Neighborhood Hits	72	Shared Neighborhood Hits	44
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS3_HUMAN
NC score	0.157383 (rank : 32)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	214	Target Neighborhood Hits	77	Shared Neighborhood Hits	44
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

CISH_MOUSE
NC score	0.155316 (rank : 33)	θ value	0.0431538 (rank : 24)
Query Neighborhood Hits	214	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SLAP1_MOUSE
NC score	0.154815 (rank : 34)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	214	Target Neighborhood Hits	117	Shared Neighborhood Hits	65
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SH24A_MOUSE
NC score	0.154310 (rank : 35)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	214	Target Neighborhood Hits	326	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

P85A_MOUSE
NC score	0.153917 (rank : 36)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	214	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

GRB14_HUMAN
NC score	0.152541 (rank : 37)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	61
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

P85A_HUMAN
NC score	0.146660 (rank : 38)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	214	Target Neighborhood Hits	479	Shared Neighborhood Hits	69
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

GRB7_HUMAN
NC score	0.146056 (rank : 39)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	214	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

LNK_MOUSE
NC score	0.145442 (rank : 40)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	214	Target Neighborhood Hits	132	Shared Neighborhood Hits	59
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

RIN1_MOUSE
NC score	0.143893 (rank : 41)	θ value	0.0252991 (rank : 20)
Query Neighborhood Hits	214	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

SHE_MOUSE
NC score	0.141361 (rank : 42)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	214	Target Neighborhood Hits	169	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

GRB7_MOUSE
NC score	0.140144 (rank : 43)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	214	Target Neighborhood Hits	157	Shared Neighborhood Hits	67
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

DAPP1_MOUSE
NC score	0.139625 (rank : 44)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	214	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CISH_HUMAN
NC score	0.139237 (rank : 45)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	214	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

PLCG1_HUMAN
NC score	0.137786 (rank : 46)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	214	Target Neighborhood Hits	293	Shared Neighborhood Hits	75
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.136962 (rank : 47)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	214	Target Neighborhood Hits	314	Shared Neighborhood Hits	75
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DAPP1_HUMAN
NC score	0.136418 (rank : 48)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

VAV2_HUMAN
NC score	0.134839 (rank : 49)	θ value	0.0431538 (rank : 28)
Query Neighborhood Hits	214	Target Neighborhood Hits	453	Shared Neighborhood Hits	74
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.132568 (rank : 50)	θ value	0.0563607 (rank : 31)
Query Neighborhood Hits	214	Target Neighborhood Hits	456	Shared Neighborhood Hits	73
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SH24A_HUMAN
NC score	0.131067 (rank : 51)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	214	Target Neighborhood Hits	455	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

LNK_HUMAN
NC score	0.130897 (rank : 52)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	214	Target Neighborhood Hits	151	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

RASA1_HUMAN
NC score	0.125680 (rank : 53)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	214	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21B_HUMAN
NC score	0.122613 (rank : 54)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	214	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PLCG2_HUMAN
NC score	0.119437 (rank : 55)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	214	Target Neighborhood Hits	280	Shared Neighborhood Hits	70
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PTN11_MOUSE
NC score	0.119168 (rank : 56)	θ value	0.125558 (rank : 43)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.119154 (rank : 57)	θ value	0.125558 (rank : 42)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

SH22A_MOUSE
NC score	0.118016 (rank : 58)	θ value	8.99809 (rank : 209)
Query Neighborhood Hits	214	Target Neighborhood Hits	179	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SOCS2_MOUSE
NC score	0.117419 (rank : 59)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	214	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SH21B_MOUSE
NC score	0.117206 (rank : 60)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	214	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ATX2_HUMAN
NC score	0.115067 (rank : 61)	θ value	0.000786445 (rank : 6)
Query Neighborhood Hits	214	Target Neighborhood Hits	375	Shared Neighborhood Hits	28
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

SHE_HUMAN
NC score	0.113815 (rank : 62)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	214	Target Neighborhood Hits	164	Shared Neighborhood Hits	73
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

RIN2_MOUSE
NC score	0.112608 (rank : 63)	θ value	0.0961366 (rank : 38)
Query Neighborhood Hits	214	Target Neighborhood Hits	72	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

APS_HUMAN
NC score	0.112359 (rank : 64)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	214	Target Neighborhood Hits	162	Shared Neighborhood Hits	62
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SHB_MOUSE
NC score	0.110966 (rank : 65)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	70
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

ATX2_MOUSE
NC score	0.110111 (rank : 66)	θ value	0.0148317 (rank : 14)
Query Neighborhood Hits	214	Target Neighborhood Hits	445	Shared Neighborhood Hits	37
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

VAV3_HUMAN
NC score	0.107578 (rank : 67)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	214	Target Neighborhood Hits	398	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CSK_MOUSE
NC score	0.107092 (rank : 68)	θ value	0.000270298 (rank : 4)
Query Neighborhood Hits	214	Target Neighborhood Hits	1009	Shared Neighborhood Hits	85
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

SOCS2_HUMAN
NC score	0.106622 (rank : 69)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	214	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

VAV3_MOUSE
NC score	0.106558 (rank : 70)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	214	Target Neighborhood Hits	404	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SHB_HUMAN
NC score	0.106434 (rank : 71)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	214	Target Neighborhood Hits	141	Shared Neighborhood Hits	70
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

CSK_HUMAN
NC score	0.106152 (rank : 72)	θ value	0.000461057 (rank : 5)
Query Neighborhood Hits	214	Target Neighborhood Hits	1009	Shared Neighborhood Hits	85
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

SHD_MOUSE
NC score	0.104304 (rank : 73)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	68
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

LCP2_HUMAN
NC score	0.101836 (rank : 74)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	214	Target Neighborhood Hits	531	Shared Neighborhood Hits	84
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

VAV_HUMAN
NC score	0.101758 (rank : 75)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	214	Target Neighborhood Hits	452	Shared Neighborhood Hits	68
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SH21A_MOUSE
NC score	0.099738 (rank : 76)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	214	Target Neighborhood Hits	89	Shared Neighborhood Hits	46
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

TXK_MOUSE
NC score	0.099174 (rank : 77)	θ value	0.00390308 (rank : 10)
Query Neighborhood Hits	214	Target Neighborhood Hits	980	Shared Neighborhood Hits	75
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BTK_HUMAN
NC score	0.099024 (rank : 78)	θ value	0.00869519 (rank : 12)
Query Neighborhood Hits	214	Target Neighborhood Hits	1026	Shared Neighborhood Hits	74
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BSN_MOUSE
NC score	0.098909 (rank : 79)	θ value	0.0431538 (rank : 23)
Query Neighborhood Hits	214	Target Neighborhood Hits	2057	Shared Neighborhood Hits	95
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PTN6_MOUSE
NC score	0.098049 (rank : 80)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	214	Target Neighborhood Hits	225	Shared Neighborhood Hits	72
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SHD_HUMAN
NC score	0.097865 (rank : 81)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	214	Target Neighborhood Hits	204	Shared Neighborhood Hits	70
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

APS_MOUSE
NC score	0.097858 (rank : 82)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	214	Target Neighborhood Hits	134	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

BTK_MOUSE
NC score	0.097266 (rank : 83)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	214	Target Neighborhood Hits	1017	Shared Neighborhood Hits	73
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FGR_MOUSE
NC score	0.096910 (rank : 84)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	214	Target Neighborhood Hits	1069	Shared Neighborhood Hits	88
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

CS016_HUMAN
NC score	0.095714 (rank : 85)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	214	Target Neighborhood Hits	310	Shared Neighborhood Hits	29
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

TXK_HUMAN
NC score	0.095557 (rank : 86)	θ value	0.0252991 (rank : 21)
Query Neighborhood Hits	214	Target Neighborhood Hits	971	Shared Neighborhood Hits	73
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

SHC3_MOUSE
NC score	0.095187 (rank : 87)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	214	Target Neighborhood Hits	151	Shared Neighborhood Hits	61
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

VAV_MOUSE
NC score	0.094751 (rank : 88)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	214	Target Neighborhood Hits	430	Shared Neighborhood Hits	65
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

BLK_MOUSE
NC score	0.094428 (rank : 89)	θ value	0.365318 (rank : 65)
Query Neighborhood Hits	214	Target Neighborhood Hits	992	Shared Neighborhood Hits	83
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MUC7_HUMAN
NC score	0.093448 (rank : 90)	θ value	0.0736092 (rank : 36)
Query Neighborhood Hits	214	Target Neighborhood Hits	538	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SRMS_HUMAN
NC score	0.092621 (rank : 91)	θ value	0.0961366 (rank : 40)
Query Neighborhood Hits	214	Target Neighborhood Hits	946	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SH21A_HUMAN
NC score	0.092569 (rank : 92)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	214	Target Neighborhood Hits	89	Shared Neighborhood Hits	44
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

LYN_MOUSE
NC score	0.091632 (rank : 93)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	214	Target Neighborhood Hits	1023	Shared Neighborhood Hits	80
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FYN_HUMAN
NC score	0.091627 (rank : 94)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	214	Target Neighborhood Hits	1078	Shared Neighborhood Hits	86
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

PTEN_MOUSE
NC score	0.091338 (rank : 95)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	214	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

PTEN_HUMAN
NC score	0.091337 (rank : 96)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	214	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

ABL2_HUMAN
NC score	0.091317 (rank : 97)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	214	Target Neighborhood Hits	1045	Shared Neighborhood Hits	89
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

TEC_HUMAN
NC score	0.090910 (rank : 98)	θ value	0.0563607 (rank : 30)
Query Neighborhood Hits	214	Target Neighborhood Hits	1006	Shared Neighborhood Hits	69
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LYN_HUMAN
NC score	0.090231 (rank : 99)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	214	Target Neighborhood Hits	1022	Shared Neighborhood Hits	79
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TEC_MOUSE
NC score	0.089884 (rank : 100)	θ value	0.0431538 (rank : 27)
Query Neighborhood Hits	214	Target Neighborhood Hits	1006	Shared Neighborhood Hits	65
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

FGR_HUMAN
NC score	0.089832 (rank : 101)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	214	Target Neighborhood Hits	1067	Shared Neighborhood Hits	85
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SOCS7_MOUSE
NC score	0.089692 (rank : 102)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	214	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

MATK_HUMAN
NC score	0.089668 (rank : 103)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	214	Target Neighborhood Hits	954	Shared Neighborhood Hits	83
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SRC_MOUSE
NC score	0.089470 (rank : 104)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	214	Target Neighborhood Hits	1033	Shared Neighborhood Hits	82
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

PTN6_HUMAN
NC score	0.089107 (rank : 105)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	214	Target Neighborhood Hits	234	Shared Neighborhood Hits	69
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

HCK_HUMAN
NC score	0.089034 (rank : 106)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	214	Target Neighborhood Hits	1035	Shared Neighborhood Hits	81
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

BLK_HUMAN
NC score	0.088847 (rank : 107)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	214	Target Neighborhood Hits	994	Shared Neighborhood Hits	76
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SHC1_MOUSE
NC score	0.088733 (rank : 108)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	214	Target Neighborhood Hits	180	Shared Neighborhood Hits	70
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ABL1_MOUSE
NC score	0.088690 (rank : 109)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	214	Target Neighborhood Hits	1178	Shared Neighborhood Hits	100
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SRMS_MOUSE
NC score	0.088582 (rank : 110)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	214	Target Neighborhood Hits	964	Shared Neighborhood Hits	80
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SH22A_HUMAN
NC score	0.088469 (rank : 111)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	214	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SRC_HUMAN
NC score	0.088422 (rank : 112)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	214	Target Neighborhood Hits	1058	Shared Neighborhood Hits	82
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ABL1_HUMAN
NC score	0.088356 (rank : 113)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	214	Target Neighborhood Hits	1220	Shared Neighborhood Hits	102
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SHC1_HUMAN
NC score	0.087903 (rank : 114)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	214	Target Neighborhood Hits	170	Shared Neighborhood Hits	64
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

HCK_MOUSE
NC score	0.087674 (rank : 115)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	214	Target Neighborhood Hits	1029	Shared Neighborhood Hits	75
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MATK_MOUSE
NC score	0.087670 (rank : 116)	θ value	1.06291 (rank : 91)
Query Neighborhood Hits	214	Target Neighborhood Hits	952	Shared Neighborhood Hits	84
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

LCK_HUMAN
NC score	0.086898 (rank : 117)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	214	Target Neighborhood Hits	987	Shared Neighborhood Hits	75
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

RIN2_HUMAN
NC score	0.086791 (rank : 118)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	214	Target Neighborhood Hits	50	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WYP3, Q00425, Q5TFT8, Q9BQL3, Q9H071	Gene names	RIN2, RASSF4
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2) (Ras inhibitor JC265) (Ras association domain family 4).

YES_HUMAN
NC score	0.086281 (rank : 119)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	214	Target Neighborhood Hits	1059	Shared Neighborhood Hits	77
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.086195 (rank : 120)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	214	Target Neighborhood Hits	1052	Shared Neighborhood Hits	76
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

LCK_MOUSE
NC score	0.085828 (rank : 121)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	214	Target Neighborhood Hits	981	Shared Neighborhood Hits	75
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

FYN_MOUSE
NC score	0.085666 (rank : 122)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	214	Target Neighborhood Hits	1073	Shared Neighborhood Hits	82
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ITK_MOUSE
NC score	0.084603 (rank : 123)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	214	Target Neighborhood Hits	985	Shared Neighborhood Hits	77
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.084566 (rank : 124)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	214	Target Neighborhood Hits	1016	Shared Neighborhood Hits	78
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SHC3_HUMAN
NC score	0.083953 (rank : 125)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	214	Target Neighborhood Hits	155	Shared Neighborhood Hits	60
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

BLNK_MOUSE
NC score	0.083700 (rank : 126)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	214	Target Neighborhood Hits	296	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
NC score	0.083636 (rank : 127)	θ value	0.163984 (rank : 45)
Query Neighborhood Hits	214	Target Neighborhood Hits	942	Shared Neighborhood Hits	73
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.083079 (rank : 128)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	214	Target Neighborhood Hits	912	Shared Neighborhood Hits	73
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

FRK_HUMAN
NC score	0.082943 (rank : 129)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	214	Target Neighborhood Hits	1058	Shared Neighborhood Hits	82
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

TPTE_HUMAN
NC score	0.082569 (rank : 130)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	214	Target Neighborhood Hits	53	Shared Neighborhood Hits	1
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

SHC2_MOUSE
NC score	0.081547 (rank : 131)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	214	Target Neighborhood Hits	144	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.080790 (rank : 132)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	214	Target Neighborhood Hits	170	Shared Neighborhood Hits	63
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

DOT1L_HUMAN
NC score	0.080287 (rank : 133)	θ value	0.125558 (rank : 41)
Query Neighborhood Hits	214	Target Neighborhood Hits	660	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

SOCS6_HUMAN
NC score	0.079884 (rank : 134)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	214	Target Neighborhood Hits	126	Shared Neighborhood Hits	49
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.079665 (rank : 135)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	214	Target Neighborhood Hits	146	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

PTK6_MOUSE
NC score	0.078657 (rank : 136)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	214	Target Neighborhood Hits	1026	Shared Neighborhood Hits	78
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTK6_HUMAN
NC score	0.078030 (rank : 137)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	214	Target Neighborhood Hits	1020	Shared Neighborhood Hits	77
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SC24C_HUMAN
NC score	0.077843 (rank : 138)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	214	Target Neighborhood Hits	662	Shared Neighborhood Hits	59
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

TPTE2_HUMAN
NC score	0.077659 (rank : 139)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	214	Target Neighborhood Hits	68	Shared Neighborhood Hits	1
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

MAGE1_HUMAN
NC score	0.075005 (rank : 140)	θ value	0.00509761 (rank : 11)
Query Neighborhood Hits	214	Target Neighborhood Hits	1389	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MBD5_HUMAN
NC score	0.074596 (rank : 141)	θ value	0.163984 (rank : 48)
Query Neighborhood Hits	214	Target Neighborhood Hits	176	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

RERE_MOUSE
NC score	0.073437 (rank : 142)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	214	Target Neighborhood Hits	785	Shared Neighborhood Hits	50
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

PCLO_MOUSE
NC score	0.073411 (rank : 143)	θ value	0.0431538 (rank : 25)
Query Neighborhood Hits	214	Target Neighborhood Hits	2275	Shared Neighborhood Hits	97
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PRG4_HUMAN
NC score	0.072162 (rank : 144)	θ value	0.0431538 (rank : 26)
Query Neighborhood Hits	214	Target Neighborhood Hits	764	Shared Neighborhood Hits	38
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

BLNK_HUMAN
NC score	0.071823 (rank : 145)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	214	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

SRRM2_MOUSE
NC score	0.071626 (rank : 146)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	214	Target Neighborhood Hits	1470	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

MDC1_MOUSE
NC score	0.071526 (rank : 147)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	214	Target Neighborhood Hits	998	Shared Neighborhood Hits	68
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NPHP1_HUMAN
NC score	0.071167 (rank : 148)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	214	Target Neighborhood Hits	288	Shared Neighborhood Hits	40
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

WASIP_MOUSE
NC score	0.070903 (rank : 149)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	214	Target Neighborhood Hits	392	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

RAPH1_HUMAN
NC score	0.070602 (rank : 150)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	214	Target Neighborhood Hits	593	Shared Neighborhood Hits	49
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

NPHP1_MOUSE
NC score	0.070431 (rank : 151)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	214	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NACAM_MOUSE
NC score	0.070429 (rank : 152)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	214	Target Neighborhood Hits	1866	Shared Neighborhood Hits	93
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ATX2L_MOUSE
NC score	0.070152 (rank : 153)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	214	Target Neighborhood Hits	401	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

PRRT3_HUMAN
NC score	0.069893 (rank : 154)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	214	Target Neighborhood Hits	998	Shared Neighborhood Hits	71
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ATX2L_HUMAN
NC score	0.069743 (rank : 155)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	214	Target Neighborhood Hits	443	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

KSYK_MOUSE
NC score	0.069349 (rank : 156)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	214	Target Neighborhood Hits	944	Shared Neighborhood Hits	77
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FER_HUMAN
NC score	0.069261 (rank : 157)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	214	Target Neighborhood Hits	1278	Shared Neighborhood Hits	84
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CIC_MOUSE
NC score	0.069083 (rank : 158)	θ value	0.21417 (rank : 51)
Query Neighborhood Hits	214	Target Neighborhood Hits	742	Shared Neighborhood Hits	59
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

MUC2_HUMAN
NC score	0.068931 (rank : 159)	θ value	0.0736092 (rank : 35)
Query Neighborhood Hits	214	Target Neighborhood Hits	906	Shared Neighborhood Hits	45
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NCOA6_HUMAN
NC score	0.068730 (rank : 160)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	214	Target Neighborhood Hits	1202	Shared Neighborhood Hits	86
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

AUXI_MOUSE
NC score	0.068674 (rank : 161)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	214	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TZ3, Q6P2K9, Q8C7L9	Gene names	Dnajc6, Kiaa0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

ACD_HUMAN
NC score	0.068659 (rank : 162)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	214	Target Neighborhood Hits	143	Shared Neighborhood Hits	23
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

KSYK_HUMAN
NC score	0.068652 (rank : 163)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	214	Target Neighborhood Hits	901	Shared Neighborhood Hits	75
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

AUXI_HUMAN
NC score	0.068548 (rank : 164)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	214	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

BCAR3_HUMAN
NC score	0.068300 (rank : 165)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	214	Target Neighborhood Hits	129	Shared Neighborhood Hits	47
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

MINT_MOUSE
NC score	0.068274 (rank : 166)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	214	Target Neighborhood Hits	1514	Shared Neighborhood Hits	73
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

LCP2_MOUSE
NC score	0.068055 (rank : 167)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	214	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

TARA_HUMAN
NC score	0.066752 (rank : 168)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	214	Target Neighborhood Hits	1626	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SH2D3_HUMAN
NC score	0.066733 (rank : 169)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	214	Target Neighborhood Hits	188	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

ZAP70_MOUSE
NC score	0.066584 (rank : 170)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	214	Target Neighborhood Hits	905	Shared Neighborhood Hits	74
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

BSN_HUMAN
NC score	0.066375 (rank : 171)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	214	Target Neighborhood Hits	1537	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

YLPM1_MOUSE
NC score	0.066345 (rank : 172)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	214	Target Neighborhood Hits	505	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

SH2D3_MOUSE
NC score	0.065539 (rank : 173)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	214	Target Neighborhood Hits	174	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

ZAP70_HUMAN
NC score	0.065517 (rank : 174)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	214	Target Neighborhood Hits	893	Shared Neighborhood Hits	74
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

BCAR3_MOUSE
NC score	0.064481 (rank : 175)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	214	Target Neighborhood Hits	127	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SRBS1_HUMAN
NC score	0.064423 (rank : 176)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	214	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.064294 (rank : 177)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	214	Target Neighborhood Hits	409	Shared Neighborhood Hits	59
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MUC1_HUMAN
NC score	0.064105 (rank : 178)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	214	Target Neighborhood Hits	975	Shared Neighborhood Hits	66
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PCLO_HUMAN
NC score	0.063359 (rank : 179)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	214	Target Neighborhood Hits	2046	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SH23A_HUMAN
NC score	0.063124 (rank : 180)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	214	Target Neighborhood Hits	149	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

RERE_HUMAN
NC score	0.063078 (rank : 181)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	214	Target Neighborhood Hits	779	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

CIC_HUMAN
NC score	0.062869 (rank : 182)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	214	Target Neighborhood Hits	992	Shared Neighborhood Hits	72
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

EFS_MOUSE
NC score	0.062669 (rank : 183)	θ value	1.06291 (rank : 90)
Query Neighborhood Hits	214	Target Neighborhood Hits	389	Shared Neighborhood Hits	58
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

NPAS4_MOUSE
NC score	0.062548 (rank : 184)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	214	Target Neighborhood Hits	245	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

VINEX_MOUSE
NC score	0.061806 (rank : 185)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	214	Target Neighborhood Hits	286	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ALEX_HUMAN
NC score	0.061647 (rank : 186)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	214	Target Neighborhood Hits	361	Shared Neighborhood Hits	37
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

SRRM2_HUMAN
NC score	0.060790 (rank : 187)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	214	Target Neighborhood Hits	1296	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

RGS3_MOUSE
NC score	0.060392 (rank : 188)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	214	Target Neighborhood Hits	1621	Shared Neighborhood Hits	89
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TAF4_HUMAN
NC score	0.060322 (rank : 189)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	214	Target Neighborhood Hits	687	Shared Neighborhood Hits	40
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

SELPL_MOUSE
NC score	0.060232 (rank : 190)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	214	Target Neighborhood Hits	588	Shared Neighborhood Hits	53
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

MDC1_HUMAN
NC score	0.059959 (rank : 191)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	214	Target Neighborhood Hits	1446	Shared Neighborhood Hits	79
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

RIN3_HUMAN
NC score	0.059928 (rank : 192)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	214	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

VINEX_HUMAN
NC score	0.059100 (rank : 193)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	214	Target Neighborhood Hits	270	Shared Neighborhood Hits	46
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCOA6_MOUSE
NC score	0.058751 (rank : 194)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	214	Target Neighborhood Hits	1076	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RIN3_MOUSE
NC score	0.057872 (rank : 195)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	214	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

CHIO_HUMAN
NC score	0.057351 (rank : 196)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	214	Target Neighborhood Hits	220	Shared Neighborhood Hits	50
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

WASIP_HUMAN
NC score	0.057132 (rank : 197)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	214	Target Neighborhood Hits	458	Shared Neighborhood Hits	34
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

BCAR1_HUMAN
NC score	0.056930 (rank : 198)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	214	Target Neighborhood Hits	554	Shared Neighborhood Hits	65
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SRRM1_MOUSE
NC score	0.056728 (rank : 199)	θ value	8.99809 (rank : 210)
Query Neighborhood Hits	214	Target Neighborhood Hits	966	Shared Neighborhood Hits	54
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TTC15_HUMAN
NC score	0.055764 (rank : 200)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	214	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVT3, Q8WVW1, Q9Y395	Gene names	TTC15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

ACK1_MOUSE
NC score	0.055689 (rank : 201)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	214	Target Neighborhood Hits	1080	Shared Neighborhood Hits	67
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACK1_HUMAN
NC score	0.055673 (rank : 202)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	214	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

STAM1_MOUSE
NC score	0.055627 (rank : 203)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	214	Target Neighborhood Hits	273	Shared Neighborhood Hits	36
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
NC score	0.055617 (rank : 204)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	214	Target Neighborhood Hits	288	Shared Neighborhood Hits	36
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAC_MOUSE
NC score	0.055611 (rank : 205)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	214	Target Neighborhood Hits	268	Shared Neighborhood Hits	36
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

OGFR_HUMAN
NC score	0.055544 (rank : 206)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	214	Target Neighborhood Hits	1582	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

FES_HUMAN
NC score	0.055342 (rank : 207)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	214	Target Neighborhood Hits	978	Shared Neighborhood Hits	58
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

GSCR1_HUMAN
NC score	0.055325 (rank : 208)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	214	Target Neighborhood Hits	674	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

AB1IP_MOUSE
NC score	0.055277 (rank : 209)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	214	Target Neighborhood Hits	181	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

AATK_MOUSE
NC score	0.055129 (rank : 210)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	214	Target Neighborhood Hits	942	Shared Neighborhood Hits	47
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

DDR1_HUMAN
NC score	0.054878 (rank : 211)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	214	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

CDN1C_HUMAN
NC score	0.054725 (rank : 212)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	214	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

AATK_HUMAN
NC score	0.054719 (rank : 213)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	214	Target Neighborhood Hits	1243	Shared Neighborhood Hits	70
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

TCGAP_HUMAN
NC score	0.054666 (rank : 214)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	214	Target Neighborhood Hits	872	Shared Neighborhood Hits	81
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STAM1_HUMAN
NC score	0.054606 (rank : 215)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	214	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CD2AP_HUMAN
NC score	0.054442 (rank : 216)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	214	Target Neighborhood Hits	315	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

EFS_HUMAN
NC score	0.054307 (rank : 217)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	214	Target Neighborhood Hits	348	Shared Neighborhood Hits	49
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ATN1_HUMAN
NC score	0.054244 (rank : 218)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	214	Target Neighborhood Hits	676	Shared Neighborhood Hits	43
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

DDR1_MOUSE
NC score	0.054053 (rank : 219)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	214	Target Neighborhood Hits	818	Shared Neighborhood Hits	35
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

FES_MOUSE
NC score	0.053806 (rank : 220)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	214	Target Neighborhood Hits	980	Shared Neighborhood Hits	57
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

DNMBP_HUMAN
NC score	0.053579 (rank : 221)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	214	Target Neighborhood Hits	413	Shared Neighborhood Hits	45
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAC_HUMAN
NC score	0.053563 (rank : 222)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	214	Target Neighborhood Hits	276	Shared Neighborhood Hits	38
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TM108_MOUSE
NC score	0.053538 (rank : 223)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	214	Target Neighborhood Hits	336	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

CHIN_MOUSE
NC score	0.053433 (rank : 224)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	214	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

NFH_MOUSE
NC score	0.053119 (rank : 225)	θ value	0.0563607 (rank : 29)
Query Neighborhood Hits	214	Target Neighborhood Hits	2247	Shared Neighborhood Hits	84
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SPN90_HUMAN
NC score	0.053046 (rank : 226)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	214	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

STYK1_HUMAN
NC score	0.052815 (rank : 227)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	214	Target Neighborhood Hits	786	Shared Neighborhood Hits	32
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

AB1IP_HUMAN
NC score	0.052552 (rank : 228)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	214	Target Neighborhood Hits	213	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

SON_HUMAN
NC score	0.052414 (rank : 229)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	214	Target Neighborhood Hits	1568	Shared Neighborhood Hits	89
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NCF2_HUMAN
NC score	0.052225 (rank : 230)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	214	Target Neighborhood Hits	229	Shared Neighborhood Hits	38
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

LTK_MOUSE
NC score	0.052138 (rank : 231)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	214	Target Neighborhood Hits	770	Shared Neighborhood Hits	34
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LTK_HUMAN
NC score	0.052131 (rank : 232)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	214	Target Neighborhood Hits	774	Shared Neighborhood Hits	32
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

STAM2_MOUSE
NC score	0.052070 (rank : 233)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	214	Target Neighborhood Hits	285	Shared Neighborhood Hits	33
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STYK1_MOUSE
NC score	0.051816 (rank : 234)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	214	Target Neighborhood Hits	779	Shared Neighborhood Hits	32
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

ALK_MOUSE
NC score	0.051770 (rank : 235)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	214	Target Neighborhood Hits	811	Shared Neighborhood Hits	36
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

MNT_MOUSE
NC score	0.051769 (rank : 236)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	214	Target Neighborhood Hits	432	Shared Neighborhood Hits	30
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

SAPS1_HUMAN
NC score	0.051719 (rank : 237)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	214	Target Neighborhood Hits	704	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

CD2AP_MOUSE
NC score	0.051477 (rank : 238)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	214	Target Neighborhood Hits	336	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ALK_HUMAN
NC score	0.051412 (rank : 239)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	214	Target Neighborhood Hits	795	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

RYK_HUMAN
NC score	0.051176 (rank : 240)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	214	Target Neighborhood Hits	701	Shared Neighborhood Hits	32
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

CBP_MOUSE
NC score	0.050984 (rank : 241)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	214	Target Neighborhood Hits	1051	Shared Neighborhood Hits	67
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

STAC3_HUMAN
NC score	0.050975 (rank : 242)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	214	Target Neighborhood Hits	228	Shared Neighborhood Hits	36
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

RYK_MOUSE
NC score	0.050893 (rank : 243)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	214	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

OSTF1_HUMAN
NC score	0.050795 (rank : 244)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	214	Target Neighborhood Hits	466	Shared Neighborhood Hits	37
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

HCLS1_HUMAN
NC score	0.050540 (rank : 245)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	214	Target Neighborhood Hits	358	Shared Neighborhood Hits	57
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GAK_HUMAN
NC score	0.050207 (rank : 246)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	214	Target Neighborhood Hits	1028	Shared Neighborhood Hits	46
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PPIP1_HUMAN
NC score	0.050164 (rank : 247)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	214	Target Neighborhood Hits	389	Shared Neighborhood Hits	44
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SPN90_MOUSE
NC score	0.050076 (rank : 248)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	214	Target Neighborhood Hits	157	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

STAC3_MOUSE
NC score	0.050056 (rank : 249)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	214	Target Neighborhood Hits	232	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ENAH_MOUSE
NC score	0.049652 (rank : 250)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	214	Target Neighborhood Hits	919	Shared Neighborhood Hits	49
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

ARI5B_MOUSE
NC score	0.049217 (rank : 251)	θ value	0.163984 (rank : 44)
Query Neighborhood Hits	214	Target Neighborhood Hits	158	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BM75, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4	Gene names	Arid5b, Desrt, Mrf2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (MRF1-like) (Modulator recognition factor protein 2) (MRF-2) (Developmentally and sexually retarded with transient immune abnormalities protein).

HAIR_MOUSE
NC score	0.048056 (rank : 252)	θ value	0.279714 (rank : 58)
Query Neighborhood Hits	214	Target Neighborhood Hits	97	Shared Neighborhood Hits	9
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

PELP1_MOUSE
NC score	0.047972 (rank : 253)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	214	Target Neighborhood Hits	709	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

SEPT9_HUMAN
NC score	0.047927 (rank : 254)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	214	Target Neighborhood Hits	706	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

MINT_HUMAN
NC score	0.047822 (rank : 255)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	214	Target Neighborhood Hits	1291	Shared Neighborhood Hits	50
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CA103_MOUSE
NC score	0.047770 (rank : 256)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	214	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDD9, Q8C893	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf103 homolog.

ATX7_MOUSE
NC score	0.046692 (rank : 257)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	214	Target Neighborhood Hits	328	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

TRI66_HUMAN
NC score	0.043793 (rank : 258)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	214	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ZN598_MOUSE
NC score	0.043661 (rank : 259)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	214	Target Neighborhood Hits	255	Shared Neighborhood Hits	11
SwissProt Accessions	Q80YR4, Q6KAT0, Q8R3S1	Gene names	Znf598, Zfp598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

RIMB1_HUMAN
NC score	0.043543 (rank : 260)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	214	Target Neighborhood Hits	1479	Shared Neighborhood Hits	70
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

HAIR_HUMAN
NC score	0.043042 (rank : 261)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	214	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

SHAN1_HUMAN
NC score	0.042426 (rank : 262)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	214	Target Neighborhood Hits	1041	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

KSR1_MOUSE
NC score	0.042062 (rank : 263)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	214	Target Neighborhood Hits	870	Shared Neighborhood Hits	36
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

PHC2_HUMAN
NC score	0.041877 (rank : 264)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	214	Target Neighborhood Hits	388	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

GGN_MOUSE
NC score	0.041021 (rank : 265)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	214	Target Neighborhood Hits	311	Shared Neighborhood Hits	29
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

MILK2_HUMAN
NC score	0.040559 (rank : 266)	θ value	5.27518 (rank : 154)
Query Neighborhood Hits	214	Target Neighborhood Hits	457	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

T22D2_HUMAN
NC score	0.040523 (rank : 267)	θ value	8.99809 (rank : 211)
Query Neighborhood Hits	214	Target Neighborhood Hits	250	Shared Neighborhood Hits	24
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TTLL4_MOUSE
NC score	0.039549 (rank : 268)	θ value	0.163984 (rank : 50)
Query Neighborhood Hits	214	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

3BP1_HUMAN
NC score	0.039216 (rank : 269)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	214	Target Neighborhood Hits	376	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

PRR12_HUMAN
NC score	0.038308 (rank : 270)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	214	Target Neighborhood Hits	460	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

DNMT1_MOUSE
NC score	0.037228 (rank : 271)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	214	Target Neighborhood Hits	137	Shared Neighborhood Hits	8
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

DIDO1_HUMAN
NC score	0.036427 (rank : 272)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	214	Target Neighborhood Hits	960	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

PARM1_HUMAN
NC score	0.036283 (rank : 273)	θ value	5.27518 (rank : 155)
Query Neighborhood Hits	214	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UWI2, Q96DV8, Q9Y4S1	Gene names	ames=UNQ1879/PRO4322
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

PSB2_HUMAN
NC score	0.035878 (rank : 274)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	214	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P49721, P31145	Gene names	PSMB2
Domain Architecture
Description	Proteasome subunit beta type 2 (EC 3.4.25.1) (Proteasome component C7- I) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I).

PSB2_MOUSE
NC score	0.035811 (rank : 275)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	214	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1P3	Gene names	Psmb2
Domain Architecture
Description	Proteasome subunit beta type 2 (EC 3.4.25.1) (Proteasome component C7- I) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I).

SPEG_HUMAN
NC score	0.034577 (rank : 276)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	214	Target Neighborhood Hits	1762	Shared Neighborhood Hits	78
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MAST4_HUMAN
NC score	0.034067 (rank : 277)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	214	Target Neighborhood Hits	1804	Shared Neighborhood Hits	91
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

CD248_MOUSE
NC score	0.032786 (rank : 278)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	214	Target Neighborhood Hits	578	Shared Neighborhood Hits	46
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

SFR15_HUMAN
NC score	0.032539 (rank : 279)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	214	Target Neighborhood Hits	368	Shared Neighborhood Hits	23
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

PITM1_HUMAN
NC score	0.032043 (rank : 280)	θ value	0.279714 (rank : 62)
Query Neighborhood Hits	214	Target Neighborhood Hits	129	Shared Neighborhood Hits	15
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

CTND2_HUMAN
NC score	0.031564 (rank : 281)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	214	Target Neighborhood Hits	333	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

WASL_MOUSE
NC score	0.031306 (rank : 282)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	214	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

PHLB1_HUMAN
NC score	0.030811 (rank : 283)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	214	Target Neighborhood Hits	1038	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SETBP_MOUSE
NC score	0.030498 (rank : 284)	θ value	8.99809 (rank : 207)
Query Neighborhood Hits	214	Target Neighborhood Hits	352	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SFPQ_MOUSE
NC score	0.029767 (rank : 285)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	214	Target Neighborhood Hits	958	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SN1L2_HUMAN
NC score	0.029361 (rank : 286)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	214	Target Neighborhood Hits	964	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

PININ_MOUSE
NC score	0.029303 (rank : 287)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	214	Target Neighborhood Hits	777	Shared Neighborhood Hits	18
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

SSPO_MOUSE
NC score	0.028289 (rank : 288)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	214	Target Neighborhood Hits	800	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

WBS14_HUMAN
NC score	0.027842 (rank : 289)	θ value	6.88961 (rank : 185)
Query Neighborhood Hits	214	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

HCN2_MOUSE
NC score	0.027306 (rank : 290)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	214	Target Neighborhood Hits	278	Shared Neighborhood Hits	25
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

PININ_HUMAN
NC score	0.026531 (rank : 291)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	214	Target Neighborhood Hits	753	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

MLL4_HUMAN
NC score	0.026496 (rank : 292)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	214	Target Neighborhood Hits	722	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

UNC5A_HUMAN
NC score	0.025777 (rank : 293)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	214	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

SNG4_MOUSE
NC score	0.025659 (rank : 294)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	214	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1L2, Q80ZT0, Q9DA94	Gene names	Syngr4
Domain Architecture
Description	Synaptogyrin-4.

K0056_HUMAN
NC score	0.025489 (rank : 295)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	214	Target Neighborhood Hits	107	Shared Neighborhood Hits	16
SwissProt Accessions	P42695	Gene names	KIAA0056
Domain Architecture	No domain graphic available
Description	Protein KIAA0056.

P2RX2_HUMAN
NC score	0.024867 (rank : 296)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	214	Target Neighborhood Hits	110	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBL9, Q6V9R6, Q9NR37, Q9NR38, Q9UHD5, Q9UHD6, Q9UHD7, Q9Y637, Q9Y638	Gene names	P2RX2, P2X2
Domain Architecture
Description	P2X purinoceptor 2 (ATP receptor) (P2X2) (Purinergic receptor).

STK6_MOUSE
NC score	0.024506 (rank : 297)	θ value	6.88961 (rank : 182)
Query Neighborhood Hits	214	Target Neighborhood Hits	886	Shared Neighborhood Hits	36
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

PKN3_MOUSE
NC score	0.024091 (rank : 298)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	214	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

UNC5A_MOUSE
NC score	0.023799 (rank : 299)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	214	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

MAML1_HUMAN
NC score	0.023013 (rank : 300)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	214	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

ZBP1_HUMAN
NC score	0.022915 (rank : 301)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	214	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

PO6F2_HUMAN
NC score	0.022812 (rank : 302)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	214	Target Neighborhood Hits	618	Shared Neighborhood Hits	31
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

CMTA2_MOUSE
NC score	0.022623 (rank : 303)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	214	Target Neighborhood Hits	216	Shared Neighborhood Hits	10
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

GORS2_HUMAN
NC score	0.021145 (rank : 304)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	214	Target Neighborhood Hits	82	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

MEF2B_MOUSE
NC score	0.020928 (rank : 305)	θ value	8.99809 (rank : 199)
Query Neighborhood Hits	214	Target Neighborhood Hits	218	Shared Neighborhood Hits	20
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

SF3A1_HUMAN
NC score	0.019672 (rank : 306)	θ value	8.99809 (rank : 208)
Query Neighborhood Hits	214	Target Neighborhood Hits	199	Shared Neighborhood Hits	18
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

PRDM2_HUMAN
NC score	0.019629 (rank : 307)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	214	Target Neighborhood Hits	1135	Shared Neighborhood Hits	36
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

PO6F2_MOUSE
NC score	0.018649 (rank : 308)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	214	Target Neighborhood Hits	639	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PDE3A_MOUSE
NC score	0.018601 (rank : 309)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	214	Target Neighborhood Hits	115	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

ZF106_HUMAN
NC score	0.017711 (rank : 310)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	214	Target Neighborhood Hits	470	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

CBL_HUMAN
NC score	0.016905 (rank : 311)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	214	Target Neighborhood Hits	353	Shared Neighborhood Hits	26
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

HXA3_MOUSE
NC score	0.016509 (rank : 312)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	214	Target Neighborhood Hits	558	Shared Neighborhood Hits	25
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

SMAD5_MOUSE
NC score	0.016453 (rank : 313)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	214	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

SOX9_HUMAN
NC score	0.016330 (rank : 314)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	214	Target Neighborhood Hits	210	Shared Neighborhood Hits	16
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

CEP68_MOUSE
NC score	0.016205 (rank : 315)	θ value	6.88961 (rank : 165)
Query Neighborhood Hits	214	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

SMAD9_MOUSE
NC score	0.015862 (rank : 316)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	214	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JIW5, Q8CFF9	Gene names	Smad9, Madh8, Madh9, Smad8
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Smad8).

SMAD5_HUMAN
NC score	0.015804 (rank : 317)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	214	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

HXA3_HUMAN
NC score	0.014685 (rank : 318)	θ value	5.27518 (rank : 153)
Query Neighborhood Hits	214	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

SMCA2_HUMAN
NC score	0.013965 (rank : 319)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	214	Target Neighborhood Hits	503	Shared Neighborhood Hits	25
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SIAH2_MOUSE
NC score	0.013710 (rank : 320)	θ value	5.27518 (rank : 158)
Query Neighborhood Hits	214	Target Neighborhood Hits	101	Shared Neighborhood Hits	7
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

KCNH3_MOUSE
NC score	0.013679 (rank : 321)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	214	Target Neighborhood Hits	133	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNKF_HUMAN
NC score	0.013455 (rank : 322)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	214	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

TISD_HUMAN
NC score	0.012621 (rank : 323)	θ value	8.99809 (rank : 212)
Query Neighborhood Hits	214	Target Neighborhood Hits	78	Shared Neighborhood Hits	6
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

SREC2_HUMAN
NC score	0.012367 (rank : 324)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	214	Target Neighborhood Hits	645	Shared Neighborhood Hits	19
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

ZBTB4_HUMAN
NC score	0.011804 (rank : 325)	θ value	6.88961 (rank : 186)
Query Neighborhood Hits	214	Target Neighborhood Hits	926	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

LPP_MOUSE
NC score	0.010902 (rank : 326)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	214	Target Neighborhood Hits	247	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

CHD4_MOUSE
NC score	0.010871 (rank : 327)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	214	Target Neighborhood Hits	408	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

TOR3A_MOUSE
NC score	0.010452 (rank : 328)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	214	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER38, Q3T9Q6, Q3TDA9, Q3U5X1, Q3U8F2, Q9CR17, Q9CU67	Gene names	Tor3a, Adir
Domain Architecture	No domain graphic available
Description	Torsin-3A precursor (Torsin family 3 member A) (ATP-dependent interferon-responsive protein).

IRTF_HUMAN
NC score	0.010061 (rank : 329)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	214	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q00978	Gene names	ISGF3G, IRF9
Domain Architecture
Description	Transcriptional regulator ISGF3 subunit gamma (Interferon regulatory factor 9) (IRF-9) (IFN-alpha-responsive transcription factor subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF3 p48 subunit) (ISGF- 3 gamma).

MYPN_MOUSE
NC score	0.010002 (rank : 330)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	214	Target Neighborhood Hits	421	Shared Neighborhood Hits	17
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

PO2F2_HUMAN
NC score	0.009950 (rank : 331)	θ value	8.99809 (rank : 202)
Query Neighborhood Hits	214	Target Neighborhood Hits	379	Shared Neighborhood Hits	16
SwissProt Accessions	P09086, Q16648, Q9BRS4	Gene names	POU2F2, OCT2, OTF2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).

PO2F2_MOUSE
NC score	0.009802 (rank : 332)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	214	Target Neighborhood Hits	353	Shared Neighborhood Hits	14
SwissProt Accessions	Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q61995, Q61996, Q64245	Gene names	Pou2f2, Oct2, Otf2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).

CHD4_HUMAN
NC score	0.008657 (rank : 333)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	214	Target Neighborhood Hits	365	Shared Neighborhood Hits	10
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

FARP2_HUMAN
NC score	0.008017 (rank : 334)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	214	Target Neighborhood Hits	240	Shared Neighborhood Hits	8
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

OSBL5_HUMAN
NC score	0.007391 (rank : 335)	θ value	8.99809 (rank : 201)
Query Neighborhood Hits	214	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

SALL3_HUMAN
NC score	0.006766 (rank : 336)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	214	Target Neighborhood Hits	1066	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

TMPS9_HUMAN
NC score	0.006418 (rank : 337)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	214	Target Neighborhood Hits	276	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

SO2B1_HUMAN
NC score	0.006247 (rank : 338)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	214	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	O94956, Q9H2Z0, Q9UFU1	Gene names	SLCO2B1, KIAA0880, OATPB, SLC21A9
Domain Architecture
Description	Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9) (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2).

LRSM1_MOUSE
NC score	0.005207 (rank : 339)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	214	Target Neighborhood Hits	874	Shared Neighborhood Hits	14
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

ABLM3_MOUSE
NC score	0.003683 (rank : 340)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	214	Target Neighborhood Hits	294	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZX8, Q52KR1, Q6PAI7	Gene names	Ablim3, Kiaa0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

SP7_MOUSE
NC score	0.003275 (rank : 341)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	214	Target Neighborhood Hits	756	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VI67, Q8C5R3, Q8C6A7	Gene names	Sp7, Osx
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix) (C22).

R4RL1_HUMAN
NC score	0.001191 (rank : 342)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	214	Target Neighborhood Hits	240	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

ZN619_HUMAN
NC score	-0.000609 (rank : 343)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	214	Target Neighborhood Hits	749	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N2I2	Gene names	ZNF619
Domain Architecture	No domain graphic available
Description	Zinc finger protein 619.

ZN319_MOUSE
NC score	-0.001225 (rank : 344)	θ value	6.88961 (rank : 187)
Query Neighborhood Hits	214	Target Neighborhood Hits	762	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERR8	Gene names	Znf319, Zfp319
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ZN319_HUMAN
NC score	-0.001440 (rank : 345)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	214	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P2F9	Gene names	ZNF319, KIAA1388
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.