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Network neighborhood for query Sequence : PTN11_HUMAN

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PTN11_HUMAN
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PTN11_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	227
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0 (rank : 2)	NC score	0.999942 (rank : 2)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	226
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	0 (rank : 3)	NC score	0.988375 (rank : 4)
Query Neighborhood Hits	227	Target Neighborhood Hits	234	Shared Neighborhood Hits	193
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	0 (rank : 4)	NC score	0.990528 (rank : 3)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	200
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTPRT_HUMAN
θ value	1.08223e-53 (rank : 5)	NC score	0.813369 (rank : 41)
Query Neighborhood Hits	227	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	1.08223e-53 (rank : 6)	NC score	0.813371 (rank : 40)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	67
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRK_HUMAN
θ value	1.41344e-53 (rank : 7)	NC score	0.818841 (rank : 37)
Query Neighborhood Hits	227	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	1.41344e-53 (rank : 8)	NC score	0.816939 (rank : 38)
Query Neighborhood Hits	227	Target Neighborhood Hits	223	Shared Neighborhood Hits	67
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRE_MOUSE
θ value	1.32293e-51 (rank : 9)	NC score	0.873465 (rank : 20)
Query Neighborhood Hits	227	Target Neighborhood Hits	86	Shared Neighborhood Hits	71
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRM_MOUSE
θ value	2.25659e-51 (rank : 10)	NC score	0.800268 (rank : 43)
Query Neighborhood Hits	227	Target Neighborhood Hits	238	Shared Neighborhood Hits	68
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_HUMAN
θ value	2.94719e-51 (rank : 11)	NC score	0.798381 (rank : 44)
Query Neighborhood Hits	227	Target Neighborhood Hits	244	Shared Neighborhood Hits	68
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRE_HUMAN
θ value	1.11993e-50 (rank : 12)	NC score	0.873285 (rank : 22)
Query Neighborhood Hits	227	Target Neighborhood Hits	92	Shared Neighborhood Hits	71
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_HUMAN
θ value	2.49495e-50 (rank : 13)	NC score	0.871823 (rank : 24)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	69
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRG_MOUSE
θ value	4.25575e-50 (rank : 14)	NC score	0.785528 (rank : 47)
Query Neighborhood Hits	227	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_HUMAN
θ value	7.25919e-50 (rank : 15)	NC score	0.788719 (rank : 46)
Query Neighborhood Hits	227	Target Neighborhood Hits	231	Shared Neighborhood Hits	65
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRD_HUMAN
θ value	8.02596e-49 (rank : 16)	NC score	0.622914 (rank : 59)
Query Neighborhood Hits	227	Target Neighborhood Hits	485	Shared Neighborhood Hits	74
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRS_HUMAN
θ value	1.04822e-48 (rank : 17)	NC score	0.634921 (rank : 58)
Query Neighborhood Hits	227	Target Neighborhood Hits	472	Shared Neighborhood Hits	74
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRB_HUMAN
θ value	2.58187e-47 (rank : 18)	NC score	0.814866 (rank : 39)
Query Neighborhood Hits	227	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRD_MOUSE
θ value	5.7518e-47 (rank : 19)	NC score	0.613153 (rank : 61)
Query Neighborhood Hits	227	Target Neighborhood Hits	491	Shared Neighborhood Hits	74
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRZ_HUMAN
θ value	5.7518e-47 (rank : 20)	NC score	0.788962 (rank : 45)
Query Neighborhood Hits	227	Target Neighborhood Hits	255	Shared Neighborhood Hits	65
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTPRF_HUMAN
θ value	7.51208e-47 (rank : 21)	NC score	0.619783 (rank : 60)
Query Neighborhood Hits	227	Target Neighborhood Hits	489	Shared Neighborhood Hits	73
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTN1_MOUSE
θ value	9.81109e-47 (rank : 22)	NC score	0.888576 (rank : 5)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN1_HUMAN
θ value	1.28137e-46 (rank : 23)	NC score	0.888249 (rank : 6)
Query Neighborhood Hits	227	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTPRJ_MOUSE
θ value	2.18568e-46 (rank : 24)	NC score	0.848632 (rank : 34)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	71
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRA_MOUSE
θ value	6.35935e-46 (rank : 25)	NC score	0.869688 (rank : 26)
Query Neighborhood Hits	227	Target Neighborhood Hits	93	Shared Neighborhood Hits	69
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTN12_MOUSE
θ value	1.41672e-45 (rank : 26)	NC score	0.880708 (rank : 16)
Query Neighborhood Hits	227	Target Neighborhood Hits	123	Shared Neighborhood Hits	67
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTPRJ_HUMAN
θ value	1.85029e-45 (rank : 27)	NC score	0.844012 (rank : 35)
Query Neighborhood Hits	227	Target Neighborhood Hits	207	Shared Neighborhood Hits	72
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTN13_MOUSE
θ value	2.41655e-45 (rank : 28)	NC score	0.667848 (rank : 56)
Query Neighborhood Hits	227	Target Neighborhood Hits	426	Shared Neighborhood Hits	73
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN13_HUMAN
θ value	3.15612e-45 (rank : 29)	NC score	0.662234 (rank : 57)
Query Neighborhood Hits	227	Target Neighborhood Hits	471	Shared Neighborhood Hits	71
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN2_HUMAN
θ value	5.38352e-45 (rank : 30)	NC score	0.886655 (rank : 8)
Query Neighborhood Hits	227	Target Neighborhood Hits	92	Shared Neighborhood Hits	64
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN12_HUMAN
θ value	1.56636e-44 (rank : 31)	NC score	0.880775 (rank : 15)
Query Neighborhood Hits	227	Target Neighborhood Hits	102	Shared Neighborhood Hits	68
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN2_MOUSE
θ value	1.56636e-44 (rank : 32)	NC score	0.886596 (rank : 9)
Query Neighborhood Hits	227	Target Neighborhood Hits	107	Shared Neighborhood Hits	65
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTPRV_MOUSE
θ value	2.04573e-44 (rank : 33)	NC score	0.838930 (rank : 36)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	67
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTN5_MOUSE
θ value	3.48949e-44 (rank : 34)	NC score	0.882518 (rank : 13)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN22_HUMAN
θ value	4.55743e-44 (rank : 35)	NC score	0.879745 (rank : 17)
Query Neighborhood Hits	227	Target Neighborhood Hits	109	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTPRR_HUMAN
θ value	2.50074e-42 (rank : 36)	NC score	0.875887 (rank : 18)
Query Neighborhood Hits	227	Target Neighborhood Hits	77	Shared Neighborhood Hits	67
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTN5_HUMAN
θ value	4.2656e-42 (rank : 37)	NC score	0.881960 (rank : 14)
Query Neighborhood Hits	227	Target Neighborhood Hits	80	Shared Neighborhood Hits	71
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTPRU_HUMAN
θ value	4.2656e-42 (rank : 38)	NC score	0.802928 (rank : 42)
Query Neighborhood Hits	227	Target Neighborhood Hits	237	Shared Neighborhood Hits	67
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

CD45_HUMAN
θ value	5.57106e-42 (rank : 39)	NC score	0.863088 (rank : 32)
Query Neighborhood Hits	227	Target Neighborhood Hits	243	Shared Neighborhood Hits	66
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

PTN18_HUMAN
θ value	5.57106e-42 (rank : 40)	NC score	0.887603 (rank : 7)
Query Neighborhood Hits	227	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTPRR_MOUSE
θ value	9.50281e-42 (rank : 41)	NC score	0.875823 (rank : 19)
Query Neighborhood Hits	227	Target Neighborhood Hits	84	Shared Neighborhood Hits	69
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTN18_MOUSE
θ value	1.2411e-41 (rank : 42)	NC score	0.885965 (rank : 11)
Query Neighborhood Hits	227	Target Neighborhood Hits	134	Shared Neighborhood Hits	74
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN4_HUMAN
θ value	1.62093e-41 (rank : 43)	NC score	0.678794 (rank : 55)
Query Neighborhood Hits	227	Target Neighborhood Hits	303	Shared Neighborhood Hits	73
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTPRO_HUMAN
θ value	2.11701e-41 (rank : 44)	NC score	0.873343 (rank : 21)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	71
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTN22_MOUSE
θ value	2.76489e-41 (rank : 45)	NC score	0.872580 (rank : 23)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	65
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTPR2_HUMAN
θ value	6.15952e-41 (rank : 46)	NC score	0.870569 (rank : 25)
Query Neighborhood Hits	227	Target Neighborhood Hits	103	Shared Neighborhood Hits	67
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	1.05066e-40 (rank : 47)	NC score	0.868883 (rank : 27)
Query Neighborhood Hits	227	Target Neighborhood Hits	120	Shared Neighborhood Hits	67
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

CD45_MOUSE
θ value	1.3722e-40 (rank : 48)	NC score	0.867692 (rank : 30)
Query Neighborhood Hits	227	Target Neighborhood Hits	178	Shared Neighborhood Hits	65
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTPRN_HUMAN
θ value	5.21438e-40 (rank : 49)	NC score	0.864863 (rank : 31)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	68
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTN9_HUMAN
θ value	6.81017e-40 (rank : 50)	NC score	0.868128 (rank : 29)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	67
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN3_HUMAN
θ value	1.51715e-39 (rank : 51)	NC score	0.700870 (rank : 54)
Query Neighborhood Hits	227	Target Neighborhood Hits	258	Shared Neighborhood Hits	69
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN21_HUMAN
θ value	2.58786e-39 (rank : 52)	NC score	0.735316 (rank : 52)
Query Neighborhood Hits	227	Target Neighborhood Hits	143	Shared Neighborhood Hits	64
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN7_HUMAN
θ value	2.58786e-39 (rank : 53)	NC score	0.886031 (rank : 10)
Query Neighborhood Hits	227	Target Neighborhood Hits	75	Shared Neighborhood Hits	67
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN9_MOUSE
θ value	2.58786e-39 (rank : 54)	NC score	0.868345 (rank : 28)
Query Neighborhood Hits	227	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN21_MOUSE
θ value	3.37985e-39 (rank : 55)	NC score	0.733569 (rank : 53)
Query Neighborhood Hits	227	Target Neighborhood Hits	155	Shared Neighborhood Hits	62
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTPRN_MOUSE
θ value	3.37985e-39 (rank : 56)	NC score	0.860376 (rank : 33)
Query Neighborhood Hits	227	Target Neighborhood Hits	240	Shared Neighborhood Hits	67
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTN7_MOUSE
θ value	1.6774e-38 (rank : 57)	NC score	0.885915 (rank : 12)
Query Neighborhood Hits	227	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN14_HUMAN
θ value	2.86122e-38 (rank : 58)	NC score	0.747171 (rank : 50)
Query Neighborhood Hits	227	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN14_MOUSE
θ value	8.32485e-38 (rank : 59)	NC score	0.741760 (rank : 51)
Query Neighborhood Hits	227	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN23_HUMAN
θ value	2.86786e-30 (rank : 60)	NC score	0.752602 (rank : 48)
Query Neighborhood Hits	227	Target Neighborhood Hits	646	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	6.38894e-30 (rank : 61)	NC score	0.751428 (rank : 49)
Query Neighborhood Hits	227	Target Neighborhood Hits	726	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PLCG1_MOUSE
θ value	1.63225e-17 (rank : 62)	NC score	0.320571 (rank : 73)
Query Neighborhood Hits	227	Target Neighborhood Hits	314	Shared Neighborhood Hits	133
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
θ value	1.058e-16 (rank : 63)	NC score	0.322278 (rank : 71)
Query Neighborhood Hits	227	Target Neighborhood Hits	293	Shared Neighborhood Hits	133
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	1.38178e-16 (rank : 64)	NC score	0.317544 (rank : 75)
Query Neighborhood Hits	227	Target Neighborhood Hits	280	Shared Neighborhood Hits	126
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NCK2_HUMAN
θ value	8.67504e-11 (rank : 65)	NC score	0.333199 (rank : 66)
Query Neighborhood Hits	227	Target Neighborhood Hits	310	Shared Neighborhood Hits	136
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
θ value	1.9326e-10 (rank : 66)	NC score	0.330312 (rank : 67)
Query Neighborhood Hits	227	Target Neighborhood Hits	312	Shared Neighborhood Hits	131
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP2_HUMAN
θ value	3.29651e-10 (rank : 67)	NC score	0.329276 (rank : 68)
Query Neighborhood Hits	227	Target Neighborhood Hits	304	Shared Neighborhood Hits	121
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

RASA1_HUMAN
θ value	4.30538e-10 (rank : 68)	NC score	0.307944 (rank : 77)
Query Neighborhood Hits	227	Target Neighborhood Hits	258	Shared Neighborhood Hits	128
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

DAPP1_HUMAN
θ value	5.62301e-10 (rank : 69)	NC score	0.349013 (rank : 62)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

FGR_MOUSE
θ value	1.63604e-09 (rank : 70)	NC score	0.175429 (rank : 136)
Query Neighborhood Hits	227	Target Neighborhood Hits	1069	Shared Neighborhood Hits	142
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

DAPP1_MOUSE
θ value	2.13673e-09 (rank : 71)	NC score	0.342127 (rank : 63)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	136
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GRAP2_MOUSE
θ value	2.13673e-09 (rank : 72)	NC score	0.322189 (rank : 72)
Query Neighborhood Hits	227	Target Neighborhood Hits	297	Shared Neighborhood Hits	121
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

YES_HUMAN
θ value	1.06045e-08 (rank : 73)	NC score	0.164897 (rank : 139)
Query Neighborhood Hits	227	Target Neighborhood Hits	1059	Shared Neighborhood Hits	125
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ABL2_HUMAN
θ value	1.38499e-08 (rank : 74)	NC score	0.164612 (rank : 140)
Query Neighborhood Hits	227	Target Neighborhood Hits	1045	Shared Neighborhood Hits	138
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

GRB14_MOUSE
θ value	1.38499e-08 (rank : 75)	NC score	0.299971 (rank : 79)
Query Neighborhood Hits	227	Target Neighborhood Hits	149	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MATK_MOUSE
θ value	1.38499e-08 (rank : 76)	NC score	0.150481 (rank : 160)
Query Neighborhood Hits	227	Target Neighborhood Hits	952	Shared Neighborhood Hits	134
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

KSYK_MOUSE
θ value	1.80886e-08 (rank : 77)	NC score	0.144030 (rank : 168)
Query Neighborhood Hits	227	Target Neighborhood Hits	944	Shared Neighborhood Hits	127
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MATK_HUMAN
θ value	1.80886e-08 (rank : 78)	NC score	0.151736 (rank : 158)
Query Neighborhood Hits	227	Target Neighborhood Hits	954	Shared Neighborhood Hits	135
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ABL1_MOUSE
θ value	5.26297e-08 (rank : 79)	NC score	0.161729 (rank : 145)
Query Neighborhood Hits	227	Target Neighborhood Hits	1178	Shared Neighborhood Hits	138
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BLK_HUMAN
θ value	5.26297e-08 (rank : 80)	NC score	0.152929 (rank : 156)
Query Neighborhood Hits	227	Target Neighborhood Hits	994	Shared Neighborhood Hits	116
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

GRB14_HUMAN
θ value	5.26297e-08 (rank : 81)	NC score	0.293144 (rank : 81)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	114
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ABL1_HUMAN
θ value	6.87365e-08 (rank : 82)	NC score	0.161997 (rank : 143)
Query Neighborhood Hits	227	Target Neighborhood Hits	1220	Shared Neighborhood Hits	138
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FYN_MOUSE
θ value	8.97725e-08 (rank : 83)	NC score	0.162843 (rank : 142)
Query Neighborhood Hits	227	Target Neighborhood Hits	1073	Shared Neighborhood Hits	130
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GRAP_HUMAN
θ value	1.17247e-07 (rank : 84)	NC score	0.339688 (rank : 64)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	126
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

YES_MOUSE
θ value	1.17247e-07 (rank : 85)	NC score	0.164273 (rank : 141)
Query Neighborhood Hits	227	Target Neighborhood Hits	1052	Shared Neighborhood Hits	125
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CSK_HUMAN
θ value	1.99992e-07 (rank : 86)	NC score	0.158961 (rank : 148)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	138
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

FYN_HUMAN
θ value	1.99992e-07 (rank : 87)	NC score	0.161510 (rank : 146)
Query Neighborhood Hits	227	Target Neighborhood Hits	1078	Shared Neighborhood Hits	136
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

GRB2_HUMAN
θ value	1.99992e-07 (rank : 88)	NC score	0.325333 (rank : 70)
Query Neighborhood Hits	227	Target Neighborhood Hits	310	Shared Neighborhood Hits	132
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	1.99992e-07 (rank : 89)	NC score	0.325592 (rank : 69)
Query Neighborhood Hits	227	Target Neighborhood Hits	312	Shared Neighborhood Hits	132
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP_MOUSE
θ value	3.41135e-07 (rank : 90)	NC score	0.338365 (rank : 65)
Query Neighborhood Hits	227	Target Neighborhood Hits	309	Shared Neighborhood Hits	126
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

KSYK_HUMAN
θ value	3.41135e-07 (rank : 91)	NC score	0.142437 (rank : 170)
Query Neighborhood Hits	227	Target Neighborhood Hits	901	Shared Neighborhood Hits	127
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CSK_MOUSE
θ value	4.45536e-07 (rank : 92)	NC score	0.158700 (rank : 149)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	138
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

LCK_MOUSE
θ value	4.45536e-07 (rank : 93)	NC score	0.156497 (rank : 154)
Query Neighborhood Hits	227	Target Neighborhood Hits	981	Shared Neighborhood Hits	121
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

VAV2_HUMAN
θ value	5.81887e-07 (rank : 94)	NC score	0.231013 (rank : 121)
Query Neighborhood Hits	227	Target Neighborhood Hits	453	Shared Neighborhood Hits	124
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	5.81887e-07 (rank : 95)	NC score	0.227912 (rank : 123)
Query Neighborhood Hits	227	Target Neighborhood Hits	456	Shared Neighborhood Hits	121
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

BMX_HUMAN
θ value	7.59969e-07 (rank : 96)	NC score	0.137341 (rank : 179)
Query Neighborhood Hits	227	Target Neighborhood Hits	942	Shared Neighborhood Hits	115
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BLK_MOUSE
θ value	9.92553e-07 (rank : 97)	NC score	0.156560 (rank : 153)
Query Neighborhood Hits	227	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMX_MOUSE
θ value	9.92553e-07 (rank : 98)	NC score	0.137329 (rank : 180)
Query Neighborhood Hits	227	Target Neighborhood Hits	912	Shared Neighborhood Hits	114
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BCAR3_HUMAN
θ value	1.29631e-06 (rank : 99)	NC score	0.240256 (rank : 113)
Query Neighborhood Hits	227	Target Neighborhood Hits	129	Shared Neighborhood Hits	94
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

FGR_HUMAN
θ value	1.29631e-06 (rank : 100)	NC score	0.167392 (rank : 138)
Query Neighborhood Hits	227	Target Neighborhood Hits	1067	Shared Neighborhood Hits	138
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LCK_HUMAN
θ value	1.29631e-06 (rank : 101)	NC score	0.157925 (rank : 150)
Query Neighborhood Hits	227	Target Neighborhood Hits	987	Shared Neighborhood Hits	123
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SHC1_MOUSE
θ value	2.21117e-06 (rank : 102)	NC score	0.292195 (rank : 82)
Query Neighborhood Hits	227	Target Neighborhood Hits	180	Shared Neighborhood Hits	125
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC3_HUMAN
θ value	2.21117e-06 (rank : 103)	NC score	0.281981 (rank : 89)
Query Neighborhood Hits	227	Target Neighborhood Hits	155	Shared Neighborhood Hits	117
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC1_HUMAN
θ value	2.88788e-06 (rank : 104)	NC score	0.290818 (rank : 83)
Query Neighborhood Hits	227	Target Neighborhood Hits	170	Shared Neighborhood Hits	123
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

VAV3_HUMAN
θ value	2.88788e-06 (rank : 105)	NC score	0.239865 (rank : 114)
Query Neighborhood Hits	227	Target Neighborhood Hits	398	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	2.88788e-06 (rank : 106)	NC score	0.239287 (rank : 115)
Query Neighborhood Hits	227	Target Neighborhood Hits	404	Shared Neighborhood Hits	116
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

BTK_HUMAN
θ value	3.77169e-06 (rank : 107)	NC score	0.147983 (rank : 162)
Query Neighborhood Hits	227	Target Neighborhood Hits	1026	Shared Neighborhood Hits	116
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FRK_HUMAN
θ value	3.77169e-06 (rank : 108)	NC score	0.155886 (rank : 155)
Query Neighborhood Hits	227	Target Neighborhood Hits	1058	Shared Neighborhood Hits	134
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

GRB7_HUMAN
θ value	3.77169e-06 (rank : 109)	NC score	0.267081 (rank : 107)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	117
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

FER_HUMAN
θ value	4.92598e-06 (rank : 110)	NC score	0.137842 (rank : 177)
Query Neighborhood Hits	227	Target Neighborhood Hits	1278	Shared Neighborhood Hits	137
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CRKL_HUMAN
θ value	6.43352e-06 (rank : 111)	NC score	0.289388 (rank : 85)
Query Neighborhood Hits	227	Target Neighborhood Hits	313	Shared Neighborhood Hits	128
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

HCK_HUMAN
θ value	6.43352e-06 (rank : 112)	NC score	0.157706 (rank : 151)
Query Neighborhood Hits	227	Target Neighborhood Hits	1035	Shared Neighborhood Hits	124
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SH24A_HUMAN
θ value	6.43352e-06 (rank : 113)	NC score	0.236950 (rank : 117)
Query Neighborhood Hits	227	Target Neighborhood Hits	455	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

GRB7_MOUSE
θ value	8.40245e-06 (rank : 114)	NC score	0.277202 (rank : 101)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	120
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HCK_MOUSE
θ value	8.40245e-06 (rank : 115)	NC score	0.157562 (rank : 152)
Query Neighborhood Hits	227	Target Neighborhood Hits	1029	Shared Neighborhood Hits	119
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SHD_MOUSE
θ value	8.40245e-06 (rank : 116)	NC score	0.285919 (rank : 86)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	120
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC3_MOUSE
θ value	1.09739e-05 (rank : 117)	NC score	0.285010 (rank : 88)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	121
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SRC_HUMAN
θ value	1.09739e-05 (rank : 118)	NC score	0.161286 (rank : 147)
Query Neighborhood Hits	227	Target Neighborhood Hits	1058	Shared Neighborhood Hits	134
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	1.09739e-05 (rank : 119)	NC score	0.161870 (rank : 144)
Query Neighborhood Hits	227	Target Neighborhood Hits	1033	Shared Neighborhood Hits	134
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

BTK_MOUSE
θ value	1.43324e-05 (rank : 120)	NC score	0.147668 (rank : 163)
Query Neighborhood Hits	227	Target Neighborhood Hits	1017	Shared Neighborhood Hits	116
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CRKL_MOUSE
θ value	1.43324e-05 (rank : 121)	NC score	0.289669 (rank : 84)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

LYN_MOUSE
θ value	1.43324e-05 (rank : 122)	NC score	0.152583 (rank : 157)
Query Neighborhood Hits	227	Target Neighborhood Hits	1023	Shared Neighborhood Hits	123
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BCAR3_MOUSE
θ value	1.87187e-05 (rank : 123)	NC score	0.234873 (rank : 119)
Query Neighborhood Hits	227	Target Neighborhood Hits	127	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SRMS_HUMAN
θ value	1.87187e-05 (rank : 124)	NC score	0.148330 (rank : 161)
Query Neighborhood Hits	227	Target Neighborhood Hits	946	Shared Neighborhood Hits	122
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	1.87187e-05 (rank : 125)	NC score	0.147453 (rank : 164)
Query Neighborhood Hits	227	Target Neighborhood Hits	964	Shared Neighborhood Hits	128
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

CRK_HUMAN
θ value	2.44474e-05 (rank : 126)	NC score	0.285062 (rank : 87)
Query Neighborhood Hits	227	Target Neighborhood Hits	308	Shared Neighborhood Hits	131
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	2.44474e-05 (rank : 127)	NC score	0.281003 (rank : 95)
Query Neighborhood Hits	227	Target Neighborhood Hits	314	Shared Neighborhood Hits	131
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SHB_HUMAN
θ value	2.44474e-05 (rank : 128)	NC score	0.279816 (rank : 98)
Query Neighborhood Hits	227	Target Neighborhood Hits	141	Shared Neighborhood Hits	121
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

ITK_MOUSE
θ value	3.19293e-05 (rank : 129)	NC score	0.140479 (rank : 173)
Query Neighborhood Hits	227	Target Neighborhood Hits	985	Shared Neighborhood Hits	118
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

GRB10_HUMAN
θ value	4.1701e-05 (rank : 130)	NC score	0.249627 (rank : 110)
Query Neighborhood Hits	227	Target Neighborhood Hits	147	Shared Neighborhood Hits	113
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	4.1701e-05 (rank : 131)	NC score	0.249097 (rank : 111)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	112
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

LYN_HUMAN
θ value	4.1701e-05 (rank : 132)	NC score	0.151689 (rank : 159)
Query Neighborhood Hits	227	Target Neighborhood Hits	1022	Shared Neighborhood Hits	123
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SH21B_HUMAN
θ value	4.1701e-05 (rank : 133)	NC score	0.319147 (rank : 74)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	98
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHB_MOUSE
θ value	4.1701e-05 (rank : 134)	NC score	0.280279 (rank : 97)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	122
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_HUMAN
θ value	4.1701e-05 (rank : 135)	NC score	0.281507 (rank : 91)
Query Neighborhood Hits	227	Target Neighborhood Hits	204	Shared Neighborhood Hits	117
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

VAV_HUMAN
θ value	4.1701e-05 (rank : 136)	NC score	0.219891 (rank : 124)
Query Neighborhood Hits	227	Target Neighborhood Hits	452	Shared Neighborhood Hits	114
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

TEC_MOUSE
θ value	5.44631e-05 (rank : 137)	NC score	0.136810 (rank : 181)
Query Neighborhood Hits	227	Target Neighborhood Hits	1006	Shared Neighborhood Hits	108
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_HUMAN
θ value	7.1131e-05 (rank : 138)	NC score	0.140142 (rank : 174)
Query Neighborhood Hits	227	Target Neighborhood Hits	1006	Shared Neighborhood Hits	112
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VAV_MOUSE
θ value	0.000121331 (rank : 139)	NC score	0.207596 (rank : 130)
Query Neighborhood Hits	227	Target Neighborhood Hits	430	Shared Neighborhood Hits	108
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ZAP70_MOUSE
θ value	0.000121331 (rank : 140)	NC score	0.129592 (rank : 189)
Query Neighborhood Hits	227	Target Neighborhood Hits	905	Shared Neighborhood Hits	122
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

LCP2_MOUSE
θ value	0.000158464 (rank : 141)	NC score	0.206066 (rank : 132)
Query Neighborhood Hits	227	Target Neighborhood Hits	177	Shared Neighborhood Hits	76
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PTK6_MOUSE
θ value	0.000158464 (rank : 142)	NC score	0.143999 (rank : 169)
Query Neighborhood Hits	227	Target Neighborhood Hits	1026	Shared Neighborhood Hits	127
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TXK_MOUSE
θ value	0.00020696 (rank : 143)	NC score	0.145398 (rank : 167)
Query Neighborhood Hits	227	Target Neighborhood Hits	980	Shared Neighborhood Hits	126
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SH24A_MOUSE
θ value	0.000270298 (rank : 144)	NC score	0.208099 (rank : 129)
Query Neighborhood Hits	227	Target Neighborhood Hits	326	Shared Neighborhood Hits	89
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SHC2_MOUSE
θ value	0.000270298 (rank : 145)	NC score	0.279656 (rank : 99)
Query Neighborhood Hits	227	Target Neighborhood Hits	144	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

TXK_HUMAN
θ value	0.000270298 (rank : 146)	NC score	0.141914 (rank : 171)
Query Neighborhood Hits	227	Target Neighborhood Hits	971	Shared Neighborhood Hits	121
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

LNK_MOUSE
θ value	0.00035302 (rank : 147)	NC score	0.280978 (rank : 96)
Query Neighborhood Hits	227	Target Neighborhood Hits	132	Shared Neighborhood Hits	111
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

P55G_MOUSE
θ value	0.00035302 (rank : 148)	NC score	0.237020 (rank : 116)
Query Neighborhood Hits	227	Target Neighborhood Hits	401	Shared Neighborhood Hits	117
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ZAP70_HUMAN
θ value	0.00035302 (rank : 149)	NC score	0.127927 (rank : 191)
Query Neighborhood Hits	227	Target Neighborhood Hits	893	Shared Neighborhood Hits	121
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ITK_HUMAN
θ value	0.000461057 (rank : 150)	NC score	0.138898 (rank : 175)
Query Neighborhood Hits	227	Target Neighborhood Hits	1016	Shared Neighborhood Hits	121
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

CHIN_MOUSE
θ value	0.000602161 (rank : 151)	NC score	0.126262 (rank : 194)
Query Neighborhood Hits	227	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SHC2_HUMAN
θ value	0.000602161 (rank : 152)	NC score	0.278480 (rank : 100)
Query Neighborhood Hits	227	Target Neighborhood Hits	170	Shared Neighborhood Hits	122
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

APS_HUMAN
θ value	0.000786445 (rank : 153)	NC score	0.281149 (rank : 94)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	111
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CHIN_HUMAN
θ value	0.000786445 (rank : 154)	NC score	0.122561 (rank : 196)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	99
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

LNK_HUMAN
θ value	0.000786445 (rank : 155)	NC score	0.276326 (rank : 102)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

CHIO_HUMAN
θ value	0.00102713 (rank : 156)	NC score	0.109650 (rank : 211)
Query Neighborhood Hits	227	Target Neighborhood Hits	220	Shared Neighborhood Hits	93
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

P55G_HUMAN
θ value	0.00102713 (rank : 157)	NC score	0.236931 (rank : 118)
Query Neighborhood Hits	227	Target Neighborhood Hits	451	Shared Neighborhood Hits	120
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PTK6_HUMAN
θ value	0.00102713 (rank : 158)	NC score	0.141696 (rank : 172)
Query Neighborhood Hits	227	Target Neighborhood Hits	1020	Shared Neighborhood Hits	125
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SLAP2_HUMAN
θ value	0.00102713 (rank : 159)	NC score	0.314378 (rank : 76)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SH2D3_HUMAN
θ value	0.00175202 (rank : 160)	NC score	0.230744 (rank : 122)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

LCP2_HUMAN
θ value	0.00228821 (rank : 161)	NC score	0.168094 (rank : 137)
Query Neighborhood Hits	227	Target Neighborhood Hits	531	Shared Neighborhood Hits	78
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SH2D3_MOUSE
θ value	0.00228821 (rank : 162)	NC score	0.232206 (rank : 120)
Query Neighborhood Hits	227	Target Neighborhood Hits	174	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

HSH2D_HUMAN
θ value	0.00298849 (rank : 163)	NC score	0.272588 (rank : 105)
Query Neighborhood Hits	227	Target Neighborhood Hits	159	Shared Neighborhood Hits	118
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

APS_MOUSE
θ value	0.00390308 (rank : 164)	NC score	0.242016 (rank : 112)
Query Neighborhood Hits	227	Target Neighborhood Hits	134	Shared Neighborhood Hits	95
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH21A_HUMAN
θ value	0.00509761 (rank : 165)	NC score	0.271472 (rank : 106)
Query Neighborhood Hits	227	Target Neighborhood Hits	89	Shared Neighborhood Hits	87
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

P85A_MOUSE
θ value	0.00665767 (rank : 166)	NC score	0.209906 (rank : 128)
Query Neighborhood Hits	227	Target Neighborhood Hits	435	Shared Neighborhood Hits	124
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_HUMAN
θ value	0.00869519 (rank : 167)	NC score	0.204845 (rank : 133)
Query Neighborhood Hits	227	Target Neighborhood Hits	479	Shared Neighborhood Hits	121
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SH21A_MOUSE
θ value	0.00869519 (rank : 168)	NC score	0.274336 (rank : 103)
Query Neighborhood Hits	227	Target Neighborhood Hits	89	Shared Neighborhood Hits	88
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

BLNK_MOUSE
θ value	0.0113563 (rank : 169)	NC score	0.134107 (rank : 183)
Query Neighborhood Hits	227	Target Neighborhood Hits	296	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SH21B_MOUSE
θ value	0.0113563 (rank : 170)	NC score	0.293388 (rank : 80)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	93
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

P85B_MOUSE
θ value	0.0148317 (rank : 171)	NC score	0.213614 (rank : 126)
Query Neighborhood Hits	227	Target Neighborhood Hits	519	Shared Neighborhood Hits	129
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SH23A_HUMAN
θ value	0.0148317 (rank : 172)	NC score	0.217862 (rank : 125)
Query Neighborhood Hits	227	Target Neighborhood Hits	149	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SOCS3_HUMAN
θ value	0.0193708 (rank : 173)	NC score	0.137638 (rank : 178)
Query Neighborhood Hits	227	Target Neighborhood Hits	77	Shared Neighborhood Hits	61
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	0.0193708 (rank : 174)	NC score	0.138673 (rank : 176)
Query Neighborhood Hits	227	Target Neighborhood Hits	72	Shared Neighborhood Hits	62
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

FES_HUMAN
θ value	0.0252991 (rank : 175)	NC score	0.111394 (rank : 209)
Query Neighborhood Hits	227	Target Neighborhood Hits	978	Shared Neighborhood Hits	100
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TENS4_MOUSE
θ value	0.0252991 (rank : 176)	NC score	0.121515 (rank : 199)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

JAK1_MOUSE
θ value	0.0330416 (rank : 177)	NC score	0.085616 (rank : 342)
Query Neighborhood Hits	227	Target Neighborhood Hits	854	Shared Neighborhood Hits	56
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

P85B_HUMAN
θ value	0.0330416 (rank : 178)	NC score	0.212923 (rank : 127)
Query Neighborhood Hits	227	Target Neighborhood Hits	543	Shared Neighborhood Hits	133
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SH22A_MOUSE
θ value	0.0330416 (rank : 179)	NC score	0.204601 (rank : 134)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SLAP2_MOUSE
θ value	0.0330416 (rank : 180)	NC score	0.307933 (rank : 78)
Query Neighborhood Hits	227	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

BLNK_HUMAN
θ value	0.0431538 (rank : 181)	NC score	0.132248 (rank : 185)
Query Neighborhood Hits	227	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

FES_MOUSE
θ value	0.0736092 (rank : 182)	NC score	0.105530 (rank : 229)
Query Neighborhood Hits	227	Target Neighborhood Hits	980	Shared Neighborhood Hits	91
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

HSH2D_MOUSE
θ value	0.0961366 (rank : 183)	NC score	0.206320 (rank : 131)
Query Neighborhood Hits	227	Target Neighborhood Hits	124	Shared Neighborhood Hits	101
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SH22A_HUMAN
θ value	0.125558 (rank : 184)	NC score	0.190315 (rank : 135)
Query Neighborhood Hits	227	Target Neighborhood Hits	144	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SHE_MOUSE
θ value	0.125558 (rank : 185)	NC score	0.261384 (rank : 108)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	0.125558 (rank : 186)	NC score	0.281595 (rank : 90)
Query Neighborhood Hits	227	Target Neighborhood Hits	113	Shared Neighborhood Hits	107
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

TENS4_HUMAN
θ value	0.125558 (rank : 187)	NC score	0.119154 (rank : 200)
Query Neighborhood Hits	227	Target Neighborhood Hits	214	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

JAK1_HUMAN
θ value	0.163984 (rank : 188)	NC score	0.082988 (rank : 372)
Query Neighborhood Hits	227	Target Neighborhood Hits	858	Shared Neighborhood Hits	55
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

SLAP1_MOUSE
θ value	0.163984 (rank : 189)	NC score	0.281494 (rank : 92)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	107
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

TENS1_HUMAN
θ value	0.21417 (rank : 190)	NC score	0.075936 (rank : 417)
Query Neighborhood Hits	227	Target Neighborhood Hits	400	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

CC14B_HUMAN
θ value	0.365318 (rank : 191)	NC score	0.146645 (rank : 166)
Query Neighborhood Hits	227	Target Neighborhood Hits	114	Shared Neighborhood Hits	60
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14B_MOUSE
θ value	0.365318 (rank : 192)	NC score	0.147194 (rank : 165)
Query Neighborhood Hits	227	Target Neighborhood Hits	103	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

SHE_HUMAN
θ value	0.365318 (rank : 193)	NC score	0.254014 (rank : 109)
Query Neighborhood Hits	227	Target Neighborhood Hits	164	Shared Neighborhood Hits	123
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

RHG25_HUMAN
θ value	0.813845 (rank : 194)	NC score	0.024364 (rank : 620)
Query Neighborhood Hits	227	Target Neighborhood Hits	550	Shared Neighborhood Hits	18
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SOCS1_HUMAN
θ value	0.813845 (rank : 195)	NC score	0.108513 (rank : 217)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	57
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	0.813845 (rank : 196)	NC score	0.113469 (rank : 204)
Query Neighborhood Hits	227	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

STAT4_MOUSE
θ value	0.813845 (rank : 197)	NC score	0.012435 (rank : 624)
Query Neighborhood Hits	227	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	P42228	Gene names	Stat4
Domain Architecture
Description	Signal transducer and activator of transcription 4.

ZWINT_MOUSE
θ value	0.813845 (rank : 198)	NC score	0.009249 (rank : 628)
Query Neighborhood Hits	227	Target Neighborhood Hits	497	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

CC14A_HUMAN
θ value	1.06291 (rank : 199)	NC score	0.129994 (rank : 187)
Query Neighborhood Hits	227	Target Neighborhood Hits	133	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_MOUSE
θ value	1.06291 (rank : 200)	NC score	0.133043 (rank : 184)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	58
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

DUS23_HUMAN
θ value	1.06291 (rank : 201)	NC score	0.272774 (rank : 104)
Query Neighborhood Hits	227	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

NALP5_MOUSE
θ value	1.06291 (rank : 202)	NC score	0.003596 (rank : 632)
Query Neighborhood Hits	227	Target Neighborhood Hits	560	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

STAT4_HUMAN
θ value	1.06291 (rank : 203)	NC score	0.011612 (rank : 625)
Query Neighborhood Hits	227	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q14765, Q96NZ6	Gene names	STAT4
Domain Architecture
Description	Signal transducer and activator of transcription 4.

DZIP1_HUMAN
θ value	1.38821 (rank : 204)	NC score	0.012542 (rank : 623)
Query Neighborhood Hits	227	Target Neighborhood Hits	675	Shared Neighborhood Hits	14
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

TP4A3_MOUSE
θ value	1.38821 (rank : 205)	NC score	0.095513 (rank : 278)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

CCD19_HUMAN
θ value	1.81305 (rank : 206)	NC score	0.003245 (rank : 633)
Query Neighborhood Hits	227	Target Neighborhood Hits	639	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

LUZP1_HUMAN
θ value	1.81305 (rank : 207)	NC score	0.002603 (rank : 634)
Query Neighborhood Hits	227	Target Neighborhood Hits	739	Shared Neighborhood Hits	13
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

SIA8C_HUMAN
θ value	1.81305 (rank : 208)	NC score	0.010082 (rank : 627)
Query Neighborhood Hits	227	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	O43173, Q9NS41	Gene names	ST8SIA3, SIAT8C
Domain Architecture
Description	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase (EC 2.4.99.-) (ST8 alpha-N-acetyl-neuraminide alpha-2,8- sialyltransferase 3) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8- sialyltransferase III) (ST8Sia III).

SIA8C_MOUSE
θ value	1.81305 (rank : 209)	NC score	0.010261 (rank : 626)
Query Neighborhood Hits	227	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q64689	Gene names	St8sia3, Siat8c
Domain Architecture
Description	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase (EC 2.4.99.-) (ST8 alpha-N-acetyl-neuraminide alpha-2,8- sialyltransferase 3) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8- sialyltransferase III) (ST8Sia III).

TP4A2_HUMAN
θ value	1.81305 (rank : 210)	NC score	0.106293 (rank : 223)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	36
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
θ value	1.81305 (rank : 211)	NC score	0.106293 (rank : 224)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	36
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

LUZP1_MOUSE
θ value	2.36792 (rank : 212)	NC score	0.000912 (rank : 636)
Query Neighborhood Hits	227	Target Neighborhood Hits	940	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

SOCS2_MOUSE
θ value	2.36792 (rank : 213)	NC score	0.136470 (rank : 182)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

TP4A1_HUMAN
θ value	2.36792 (rank : 214)	NC score	0.122322 (rank : 197)
Query Neighborhood Hits	227	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
θ value	2.36792 (rank : 215)	NC score	0.122322 (rank : 198)
Query Neighborhood Hits	227	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

HM20A_HUMAN
θ value	3.0926 (rank : 216)	NC score	0.007271 (rank : 630)
Query Neighborhood Hits	227	Target Neighborhood Hits	343	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NP66, Q53G31, Q9NSF6	Gene names	HMG20A, HMGX1
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein HMGX1).

HM20A_MOUSE
θ value	3.0926 (rank : 217)	NC score	0.007186 (rank : 631)
Query Neighborhood Hits	227	Target Neighborhood Hits	348	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DC33, Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2	Gene names	Hmg20a, Ibraf
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (iBRAF) (Inhibitor of BRAF35) (HMG domain protein HMGX1).

CISH_HUMAN
θ value	4.03905 (rank : 218)	NC score	0.107256 (rank : 220)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
θ value	4.03905 (rank : 219)	NC score	0.108668 (rank : 216)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

GOGA4_HUMAN
θ value	4.03905 (rank : 220)	NC score	-0.003549 (rank : 637)
Query Neighborhood Hits	227	Target Neighborhood Hits	2034	Shared Neighborhood Hits	27
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

ITA9_HUMAN
θ value	4.03905 (rank : 221)	NC score	0.001882 (rank : 635)
Query Neighborhood Hits	227	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q13797, Q14638	Gene names	ITGA9
Domain Architecture
Description	Integrin alpha-9 precursor (Integrin alpha-RLC).

TP4A3_HUMAN
θ value	4.03905 (rank : 222)	NC score	0.103187 (rank : 243)
Query Neighborhood Hits	227	Target Neighborhood Hits	62	Shared Neighborhood Hits	35
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

DUS23_MOUSE
θ value	5.27518 (rank : 223)	NC score	0.281352 (rank : 93)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	58
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

ROCK1_MOUSE
θ value	5.27518 (rank : 224)	NC score	0.018931 (rank : 622)
Query Neighborhood Hits	227	Target Neighborhood Hits	2126	Shared Neighborhood Hits	66
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RPF53_HUMAN
θ value	6.88961 (rank : 225)	NC score	0.008975 (rank : 629)
Query Neighborhood Hits	227	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9GZS1, Q5VZT3, Q8NBA9, Q96L20	Gene names	PRAF1, PAF53
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase I-associated factor 53 kDa subunit (EC 2.7.7.6) (RNA polymerase I-associated factor 1).

ROCK1_HUMAN
θ value	8.99809 (rank : 226)	NC score	0.019164 (rank : 621)
Query Neighborhood Hits	227	Target Neighborhood Hits	2000	Shared Neighborhood Hits	64
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

SOCS2_HUMAN
θ value	8.99809 (rank : 227)	NC score	0.125511 (rank : 195)
Query Neighborhood Hits	227	Target Neighborhood Hits	104	Shared Neighborhood Hits	78
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

41_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.102439 (rank : 249)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.101896 (rank : 251)
Query Neighborhood Hits	227	Target Neighborhood Hits	184	Shared Neighborhood Hits	13
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

AATK_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.084197 (rank : 364)
Query Neighborhood Hits	227	Target Neighborhood Hits	1243	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.086357 (rank : 332)
Query Neighborhood Hits	227	Target Neighborhood Hits	942	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

AB1IP_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.052034 (rank : 605)
Query Neighborhood Hits	227	Target Neighborhood Hits	213	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.051069 (rank : 612)
Query Neighborhood Hits	227	Target Neighborhood Hits	181	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ABI1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.061588 (rank : 525)
Query Neighborhood Hits	227	Target Neighborhood Hits	257	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.064182 (rank : 502)
Query Neighborhood Hits	227	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.074798 (rank : 427)
Query Neighborhood Hits	227	Target Neighborhood Hits	350	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.073474 (rank : 436)
Query Neighborhood Hits	227	Target Neighborhood Hits	266	Shared Neighborhood Hits	48
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.061499 (rank : 526)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.062187 (rank : 518)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ACK1_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.092362 (rank : 289)
Query Neighborhood Hits	227	Target Neighborhood Hits	1140	Shared Neighborhood Hits	59
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.093558 (rank : 282)
Query Neighborhood Hits	227	Target Neighborhood Hits	1080	Shared Neighborhood Hits	60
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.055434 (rank : 579)
Query Neighborhood Hits	227	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.055481 (rank : 578)
Query Neighborhood Hits	227	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.057910 (rank : 557)
Query Neighborhood Hits	227	Target Neighborhood Hits	709	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.057421 (rank : 563)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.058636 (rank : 549)
Query Neighborhood Hits	227	Target Neighborhood Hits	716	Shared Neighborhood Hits	49
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.058511 (rank : 553)
Query Neighborhood Hits	227	Target Neighborhood Hits	739	Shared Neighborhood Hits	49
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.053409 (rank : 592)
Query Neighborhood Hits	227	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.053683 (rank : 589)
Query Neighborhood Hits	227	Target Neighborhood Hits	768	Shared Neighborhood Hits	49
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AHI1_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.075160 (rank : 424)
Query Neighborhood Hits	227	Target Neighborhood Hits	537	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.072419 (rank : 447)
Query Neighborhood Hits	227	Target Neighborhood Hits	496	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALK_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.090089 (rank : 308)
Query Neighborhood Hits	227	Target Neighborhood Hits	795	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.091194 (rank : 299)
Query Neighborhood Hits	227	Target Neighborhood Hits	811	Shared Neighborhood Hits	52
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.055179 (rank : 582)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANM2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.064990 (rank : 495)
Query Neighborhood Hits	227	Target Neighborhood Hits	175	Shared Neighborhood Hits	47
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.060761 (rank : 535)
Query Neighborhood Hits	227	Target Neighborhood Hits	175	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANPRA_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.072926 (rank : 443)
Query Neighborhood Hits	227	Target Neighborhood Hits	612	Shared Neighborhood Hits	49
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.072934 (rank : 442)
Query Neighborhood Hits	227	Target Neighborhood Hits	600	Shared Neighborhood Hits	49
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.068537 (rank : 472)
Query Neighborhood Hits	227	Target Neighborhood Hits	646	Shared Neighborhood Hits	53
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.069058 (rank : 469)
Query Neighborhood Hits	227	Target Neighborhood Hits	607	Shared Neighborhood Hits	53
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.069357 (rank : 463)
Query Neighborhood Hits	227	Target Neighborhood Hits	924	Shared Neighborhood Hits	58
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.069118 (rank : 467)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	56
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG4_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.054858 (rank : 585)
Query Neighborhood Hits	227	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.077355 (rank : 409)
Query Neighborhood Hits	227	Target Neighborhood Hits	376	Shared Neighborhood Hits	49
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.072261 (rank : 448)
Query Neighborhood Hits	227	Target Neighborhood Hits	394	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.077185 (rank : 410)
Query Neighborhood Hits	227	Target Neighborhood Hits	347	Shared Neighborhood Hits	48
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.078404 (rank : 398)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

BMR1A_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.062044 (rank : 521)
Query Neighborhood Hits	227	Target Neighborhood Hits	759	Shared Neighborhood Hits	49
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.062141 (rank : 520)
Query Neighborhood Hits	227	Target Neighborhood Hits	758	Shared Neighborhood Hits	49
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.064227 (rank : 500)
Query Neighborhood Hits	227	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.064117 (rank : 503)
Query Neighborhood Hits	227	Target Neighborhood Hits	758	Shared Neighborhood Hits	49
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BRAF1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.069169 (rank : 466)
Query Neighborhood Hits	227	Target Neighborhood Hits	883	Shared Neighborhood Hits	59
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CAH12_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.053455 (rank : 591)
Query Neighborhood Hits	227	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	O43570, Q53YE5, Q9BWG2	Gene names	CA12
Domain Architecture
Description	Carbonic anhydrase 12 precursor (EC 4.2.1.1) (Carbonic anhydrase XII) (Carbonate dehydratase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3).

CAH12_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.053369 (rank : 593)
Query Neighborhood Hits	227	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CI85, Q8BKG6	Gene names	Ca12, Car12
Domain Architecture
Description	Carbonic anhydrase 12 precursor (EC 4.2.1.1) (Carbonic anhydrase XII) (Carbonate dehydratase XII) (CA-XII).

CAH14_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.054998 (rank : 583)
Query Neighborhood Hits	227	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULX7, Q5TB24, Q8NCF4	Gene names	CA14
Domain Architecture
Description	Carbonic anhydrase 14 precursor (EC 4.2.1.1) (Carbonic anhydrase XIV) (Carbonate dehydratase XIV) (CA-XIV).

CAH14_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.052328 (rank : 604)
Query Neighborhood Hits	227	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVT6	Gene names	Ca14, Car14, Catm
Domain Architecture
Description	Carbonic anhydrase 14 precursor (EC 4.2.1.1) (Carbonic anhydrase XIV) (Carbonate dehydratase XIV) (CA-XIV).

CAH15_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.052667 (rank : 601)
Query Neighborhood Hits	227	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q99N23	Gene names	Ca15, Car15
Domain Architecture
Description	Carbonic anhydrase 15 precursor (EC 4.2.1.1) (Carbonic anhydrase XV) (Carbonate dehydratase XV) (CA-XV).

CAH4_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.053798 (rank : 588)
Query Neighborhood Hits	227	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	P22748	Gene names	CA4
Domain Architecture
Description	Carbonic anhydrase 4 precursor (EC 4.2.1.1) (Carbonic anhydrase IV) (Carbonate dehydratase IV) (CA-IV).

CAH4_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.052885 (rank : 598)
Query Neighborhood Hits	227	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q64444	Gene names	Ca4, Car4
Domain Architecture
Description	Carbonic anhydrase 4 precursor (EC 4.2.1.1) (Carbonic anhydrase IV) (Carbonate dehydratase IV) (CA-IV).

CAH6_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.051142 (rank : 611)
Query Neighborhood Hits	227	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	P18761, O88625	Gene names	Ca6, Car6
Domain Architecture
Description	Carbonic anhydrase 6 precursor (EC 4.2.1.1) (Carbonic anhydrase VI) (Carbonate dehydratase VI) (CA-VI) (Secreted carbonic anhydrase) (Salivary carbonic anhydrase).

CD2AP_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.088690 (rank : 316)
Query Neighborhood Hits	227	Target Neighborhood Hits	315	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.087671 (rank : 320)
Query Neighborhood Hits	227	Target Neighborhood Hits	336	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CDKN3_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.074491 (rank : 431)
Query Neighborhood Hits	227	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

CHL1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.052001 (rank : 606)
Query Neighborhood Hits	227	Target Neighborhood Hits	413	Shared Neighborhood Hits	11
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CHL1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.050458 (rank : 614)
Query Neighborhood Hits	227	Target Neighborhood Hits	402	Shared Neighborhood Hits	14
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CIP4_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.062533 (rank : 515)
Query Neighborhood Hits	227	Target Neighborhood Hits	374	Shared Neighborhood Hits	45
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CNTN1_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.062142 (rank : 519)
Query Neighborhood Hits	227	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.063507 (rank : 509)
Query Neighborhood Hits	227	Target Neighborhood Hits	422	Shared Neighborhood Hits	12
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN2_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.067000 (rank : 480)
Query Neighborhood Hits	227	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.066858 (rank : 481)
Query Neighborhood Hits	227	Target Neighborhood Hits	450	Shared Neighborhood Hits	12
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN3_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.058629 (rank : 550)
Query Neighborhood Hits	227	Target Neighborhood Hits	455	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN3_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.061306 (rank : 528)
Query Neighborhood Hits	227	Target Neighborhood Hits	447	Shared Neighborhood Hits	16
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN4_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.053518 (rank : 590)
Query Neighborhood Hits	227	Target Neighborhood Hits	449	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.052983 (rank : 597)
Query Neighborhood Hits	227	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN5_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.069206 (rank : 465)
Query Neighborhood Hits	227	Target Neighborhood Hits	446	Shared Neighborhood Hits	15
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CNTN5_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.067610 (rank : 475)
Query Neighborhood Hits	227	Target Neighborhood Hits	434	Shared Neighborhood Hits	14
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

CNTN6_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.060210 (rank : 538)
Query Neighborhood Hits	227	Target Neighborhood Hits	422	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN6_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.052738 (rank : 600)
Query Neighborhood Hits	227	Target Neighborhood Hits	429	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CO7A1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.064617 (rank : 498)
Query Neighborhood Hits	227	Target Neighborhood Hits	807	Shared Neighborhood Hits	16
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

COCA1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.083183 (rank : 370)
Query Neighborhood Hits	227	Target Neighborhood Hits	458	Shared Neighborhood Hits	22
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COCA1_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.085519 (rank : 345)
Query Neighborhood Hits	227	Target Neighborhood Hits	467	Shared Neighborhood Hits	20
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COEA1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.061387 (rank : 527)
Query Neighborhood Hits	227	Target Neighborhood Hits	427	Shared Neighborhood Hits	14
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

COEA1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.069096 (rank : 468)
Query Neighborhood Hits	227	Target Neighborhood Hits	402	Shared Neighborhood Hits	15
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

COKA1_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.055987 (rank : 574)
Query Neighborhood Hits	227	Target Neighborhood Hits	403	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

CSF1R_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.090060 (rank : 309)
Query Neighborhood Hits	227	Target Neighborhood Hits	943	Shared Neighborhood Hits	53
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.087435 (rank : 321)
Query Neighborhood Hits	227	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

DBNL_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.060902 (rank : 532)
Query Neighborhood Hits	227	Target Neighborhood Hits	244	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.059806 (rank : 542)
Query Neighborhood Hits	227	Target Neighborhood Hits	306	Shared Neighborhood Hits	48
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DCC_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.096167 (rank : 275)
Query Neighborhood Hits	227	Target Neighborhood Hits	583	Shared Neighborhood Hits	21
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.092722 (rank : 286)
Query Neighborhood Hits	227	Target Neighborhood Hits	896	Shared Neighborhood Hits	24
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DDR1_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.086872 (rank : 326)
Query Neighborhood Hits	227	Target Neighborhood Hits	819	Shared Neighborhood Hits	52
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.087161 (rank : 324)
Query Neighborhood Hits	227	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.082762 (rank : 373)
Query Neighborhood Hits	227	Target Neighborhood Hits	818	Shared Neighborhood Hits	49
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.082618 (rank : 376)
Query Neighborhood Hits	227	Target Neighborhood Hits	813	Shared Neighborhood Hits	49
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DNMBP_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.080319 (rank : 388)
Query Neighborhood Hits	227	Target Neighborhood Hits	413	Shared Neighborhood Hits	58
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.075234 (rank : 423)
Query Neighborhood Hits	227	Target Neighborhood Hits	435	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DSCAM_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.070614 (rank : 457)
Query Neighborhood Hits	227	Target Neighborhood Hits	524	Shared Neighborhood Hits	17
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.070546 (rank : 458)
Query Neighborhood Hits	227	Target Neighborhood Hits	589	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DUET_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.050067 (rank : 618)
Query Neighborhood Hits	227	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

E41L1_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.099909 (rank : 259)
Query Neighborhood Hits	227	Target Neighborhood Hits	180	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.100465 (rank : 257)
Query Neighborhood Hits	227	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.101098 (rank : 254)
Query Neighborhood Hits	227	Target Neighborhood Hits	287	Shared Neighborhood Hits	12
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.095847 (rank : 276)
Query Neighborhood Hits	227	Target Neighborhood Hits	459	Shared Neighborhood Hits	8
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.102459 (rank : 248)
Query Neighborhood Hits	227	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.099163 (rank : 261)
Query Neighborhood Hits	227	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.104445 (rank : 235)
Query Neighborhood Hits	227	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.109511 (rank : 212)
Query Neighborhood Hits	227	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.109961 (rank : 210)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.103693 (rank : 240)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.106068 (rank : 225)
Query Neighborhood Hits	227	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EGFR_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.082672 (rank : 375)
Query Neighborhood Hits	227	Target Neighborhood Hits	939	Shared Neighborhood Hits	49
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.083153 (rank : 371)
Query Neighborhood Hits	227	Target Neighborhood Hits	927	Shared Neighborhood Hits	50
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.090100 (rank : 306)
Query Neighborhood Hits	227	Target Neighborhood Hits	997	Shared Neighborhood Hits	54
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.090099 (rank : 307)
Query Neighborhood Hits	227	Target Neighborhood Hits	958	Shared Neighborhood Hits	56
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.094647 (rank : 280)
Query Neighborhood Hits	227	Target Neighborhood Hits	1021	Shared Neighborhood Hits	61
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.091799 (rank : 294)
Query Neighborhood Hits	227	Target Neighborhood Hits	1020	Shared Neighborhood Hits	59
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.103444 (rank : 241)
Query Neighborhood Hits	227	Target Neighborhood Hits	1005	Shared Neighborhood Hits	63
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.105516 (rank : 230)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	63
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.103986 (rank : 237)
Query Neighborhood Hits	227	Target Neighborhood Hits	975	Shared Neighborhood Hits	63
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.104371 (rank : 236)
Query Neighborhood Hits	227	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.102610 (rank : 246)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	65
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.103874 (rank : 238)
Query Neighborhood Hits	227	Target Neighborhood Hits	950	Shared Neighborhood Hits	65
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.103050 (rank : 244)
Query Neighborhood Hits	227	Target Neighborhood Hits	959	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.100889 (rank : 256)
Query Neighborhood Hits	227	Target Neighborhood Hits	946	Shared Neighborhood Hits	62
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.105597 (rank : 228)
Query Neighborhood Hits	227	Target Neighborhood Hits	1053	Shared Neighborhood Hits	65
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.106002 (rank : 227)
Query Neighborhood Hits	227	Target Neighborhood Hits	1025	Shared Neighborhood Hits	66
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.105182 (rank : 232)
Query Neighborhood Hits	227	Target Neighborhood Hits	956	Shared Neighborhood Hits	65
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.105316 (rank : 231)
Query Neighborhood Hits	227	Target Neighborhood Hits	969	Shared Neighborhood Hits	65
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.096453 (rank : 273)
Query Neighborhood Hits	227	Target Neighborhood Hits	960	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.096953 (rank : 270)
Query Neighborhood Hits	227	Target Neighborhood Hits	988	Shared Neighborhood Hits	61
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.099141 (rank : 262)
Query Neighborhood Hits	227	Target Neighborhood Hits	983	Shared Neighborhood Hits	62
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.099175 (rank : 260)
Query Neighborhood Hits	227	Target Neighborhood Hits	982	Shared Neighborhood Hits	62
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.097407 (rank : 267)
Query Neighborhood Hits	227	Target Neighborhood Hits	996	Shared Neighborhood Hits	62
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.098619 (rank : 265)
Query Neighborhood Hits	227	Target Neighborhood Hits	996	Shared Neighborhood Hits	63
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.096833 (rank : 271)
Query Neighborhood Hits	227	Target Neighborhood Hits	1056	Shared Neighborhood Hits	64
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.097847 (rank : 266)
Query Neighborhood Hits	227	Target Neighborhood Hits	1013	Shared Neighborhood Hits	64
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.113525 (rank : 203)
Query Neighborhood Hits	227	Target Neighborhood Hits	912	Shared Neighborhood Hits	65
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.112501 (rank : 208)
Query Neighborhood Hits	227	Target Neighborhood Hits	906	Shared Neighborhood Hits	63
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPS8_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.051199 (rank : 610)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.053300 (rank : 595)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ERBB2_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.085375 (rank : 347)
Query Neighborhood Hits	227	Target Neighborhood Hits	1073	Shared Neighborhood Hits	52
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.084992 (rank : 355)
Query Neighborhood Hits	227	Target Neighborhood Hits	918	Shared Neighborhood Hits	49
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.085865 (rank : 339)
Query Neighborhood Hits	227	Target Neighborhood Hits	918	Shared Neighborhood Hits	49
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.085573 (rank : 343)
Query Neighborhood Hits	227	Target Neighborhood Hits	898	Shared Neighborhood Hits	49
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.085364 (rank : 348)
Query Neighborhood Hits	227	Target Neighborhood Hits	910	Shared Neighborhood Hits	51
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.064461 (rank : 499)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.052450 (rank : 603)
Query Neighborhood Hits	227	Target Neighborhood Hits	143	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.065921 (rank : 487)
Query Neighborhood Hits	227	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.067356 (rank : 476)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	54
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.079955 (rank : 389)
Query Neighborhood Hits	227	Target Neighborhood Hits	206	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.072075 (rank : 449)
Query Neighborhood Hits	227	Target Neighborhood Hits	168	Shared Neighborhood Hits	50
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EZRI_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.077977 (rank : 403)
Query Neighborhood Hits	227	Target Neighborhood Hits	663	Shared Neighborhood Hits	22
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.077156 (rank : 411)
Query Neighborhood Hits	227	Target Neighborhood Hits	693	Shared Neighborhood Hits	22
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FAK1_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.083600 (rank : 369)
Query Neighborhood Hits	227	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.083639 (rank : 368)
Query Neighborhood Hits	227	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.087364 (rank : 322)
Query Neighborhood Hits	227	Target Neighborhood Hits	847	Shared Neighborhood Hits	49
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.086783 (rank : 327)
Query Neighborhood Hits	227	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FARP1_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.086123 (rank : 334)
Query Neighborhood Hits	227	Target Neighborhood Hits	241	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.084108 (rank : 366)
Query Neighborhood Hits	227	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.089200 (rank : 314)
Query Neighborhood Hits	227	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGFR1_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.085218 (rank : 351)
Query Neighborhood Hits	227	Target Neighborhood Hits	1069	Shared Neighborhood Hits	53
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.085148 (rank : 353)
Query Neighborhood Hits	227	Target Neighborhood Hits	1068	Shared Neighborhood Hits	53
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.086309 (rank : 333)
Query Neighborhood Hits	227	Target Neighborhood Hits	1062	Shared Neighborhood Hits	53
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.085490 (rank : 346)
Query Neighborhood Hits	227	Target Neighborhood Hits	1062	Shared Neighborhood Hits	53
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.085899 (rank : 338)
Query Neighborhood Hits	227	Target Neighborhood Hits	1042	Shared Neighborhood Hits	53
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.085791 (rank : 340)
Query Neighborhood Hits	227	Target Neighborhood Hits	1059	Shared Neighborhood Hits	53
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.089225 (rank : 313)
Query Neighborhood Hits	227	Target Neighborhood Hits	1037	Shared Neighborhood Hits	53
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.091652 (rank : 296)
Query Neighborhood Hits	227	Target Neighborhood Hits	1026	Shared Neighborhood Hits	53
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FINC_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.128176 (rank : 190)
Query Neighborhood Hits	227	Target Neighborhood Hits	302	Shared Neighborhood Hits	20
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

FINC_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.127609 (rank : 193)
Query Neighborhood Hits	227	Target Neighborhood Hits	309	Shared Neighborhood Hits	22
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

FLT3_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.085280 (rank : 350)
Query Neighborhood Hits	227	Target Neighborhood Hits	843	Shared Neighborhood Hits	49
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.085620 (rank : 341)
Query Neighborhood Hits	227	Target Neighborhood Hits	847	Shared Neighborhood Hits	49
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FNBP2_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.052521 (rank : 602)
Query Neighborhood Hits	227	Target Neighborhood Hits	432	Shared Neighborhood Hits	56
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FNDC3_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.116828 (rank : 202)
Query Neighborhood Hits	227	Target Neighborhood Hits	196	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.108964 (rank : 215)
Query Neighborhood Hits	227	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FRM4A_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.090304 (rank : 305)
Query Neighborhood Hits	227	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.088573 (rank : 318)
Query Neighborhood Hits	227	Target Neighborhood Hits	108	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4B_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.090670 (rank : 301)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.092104 (rank : 293)
Query Neighborhood Hits	227	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

FRMD1_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.117785 (rank : 201)
Query Neighborhood Hits	227	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

FRMD5_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.101532 (rank : 252)
Query Neighborhood Hits	227	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.102460 (rank : 247)
Query Neighborhood Hits	227	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD6_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.109288 (rank : 213)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	8
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.112877 (rank : 206)
Query Neighborhood Hits	227	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

GUC2C_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.074075 (rank : 432)
Query Neighborhood Hits	227	Target Neighborhood Hits	624	Shared Neighborhood Hits	49
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.065539 (rank : 490)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.066651 (rank : 483)
Query Neighborhood Hits	227	Target Neighborhood Hits	692	Shared Neighborhood Hits	48
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.075253 (rank : 422)
Query Neighborhood Hits	227	Target Neighborhood Hits	740	Shared Neighborhood Hits	49
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.065070 (rank : 494)
Query Neighborhood Hits	227	Target Neighborhood Hits	644	Shared Neighborhood Hits	46
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCLS1_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.077599 (rank : 406)
Query Neighborhood Hits	227	Target Neighborhood Hits	358	Shared Neighborhood Hits	50
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.077419 (rank : 408)
Query Neighborhood Hits	227	Target Neighborhood Hits	329	Shared Neighborhood Hits	54
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IGF1R_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.105107 (rank : 233)
Query Neighborhood Hits	227	Target Neighborhood Hits	977	Shared Neighborhood Hits	61
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.104988 (rank : 234)
Query Neighborhood Hits	227	Target Neighborhood Hits	973	Shared Neighborhood Hits	61
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IL6RB_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.051477 (rank : 608)
Query Neighborhood Hits	227	Target Neighborhood Hits	181	Shared Neighborhood Hits	9
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

ILK1_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.070772 (rank : 456)
Query Neighborhood Hits	227	Target Neighborhood Hits	857	Shared Neighborhood Hits	49
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.070001 (rank : 461)
Query Neighborhood Hits	227	Target Neighborhood Hits	848	Shared Neighborhood Hits	49
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.071487 (rank : 452)
Query Neighborhood Hits	227	Target Neighborhood Hits	858	Shared Neighborhood Hits	49
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.101320 (rank : 253)
Query Neighborhood Hits	227	Target Neighborhood Hits	950	Shared Neighborhood Hits	62
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.097013 (rank : 269)
Query Neighborhood Hits	227	Target Neighborhood Hits	961	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.098838 (rank : 264)
Query Neighborhood Hits	227	Target Neighborhood Hits	963	Shared Neighborhood Hits	60
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.099122 (rank : 263)
Query Neighborhood Hits	227	Target Neighborhood Hits	968	Shared Neighborhood Hits	60
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.061040 (rank : 530)
Query Neighborhood Hits	227	Target Neighborhood Hits	820	Shared Neighborhood Hits	49
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.065177 (rank : 492)
Query Neighborhood Hits	227	Target Neighborhood Hits	784	Shared Neighborhood Hits	50
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.054861 (rank : 584)
Query Neighborhood Hits	227	Target Neighborhood Hits	714	Shared Neighborhood Hits	46
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.063928 (rank : 507)
Query Neighborhood Hits	227	Target Neighborhood Hits	644	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.066131 (rank : 485)
Query Neighborhood Hits	227	Target Neighborhood Hits	628	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.059851 (rank : 541)
Query Neighborhood Hits	227	Target Neighborhood Hits	816	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.057376 (rank : 564)
Query Neighborhood Hits	227	Target Neighborhood Hits	820	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITB4_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.074626 (rank : 429)
Query Neighborhood Hits	227	Target Neighborhood Hits	458	Shared Neighborhood Hits	16
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

ITSN1_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.058282 (rank : 555)
Query Neighborhood Hits	227	Target Neighborhood Hits	1757	Shared Neighborhood Hits	78
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.059322 (rank : 545)
Query Neighborhood Hits	227	Target Neighborhood Hits	1669	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.066670 (rank : 482)
Query Neighborhood Hits	227	Target Neighborhood Hits	1173	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.062579 (rank : 514)
Query Neighborhood Hits	227	Target Neighborhood Hits	1371	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JAK2_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.072828 (rank : 444)
Query Neighborhood Hits	227	Target Neighborhood Hits	847	Shared Neighborhood Hits	51
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.073443 (rank : 437)
Query Neighborhood Hits	227	Target Neighborhood Hits	839	Shared Neighborhood Hits	52
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.075415 (rank : 420)
Query Neighborhood Hits	227	Target Neighborhood Hits	827	Shared Neighborhood Hits	49
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.072810 (rank : 445)
Query Neighborhood Hits	227	Target Neighborhood Hits	821	Shared Neighborhood Hits	49
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KALM_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.051416 (rank : 609)
Query Neighborhood Hits	227	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

KIT_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.085948 (rank : 337)
Query Neighborhood Hits	227	Target Neighborhood Hits	953	Shared Neighborhood Hits	53
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.087139 (rank : 325)
Query Neighborhood Hits	227	Target Neighborhood Hits	949	Shared Neighborhood Hits	53
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSR1_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.065116 (rank : 493)
Query Neighborhood Hits	227	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.064723 (rank : 497)
Query Neighborhood Hits	227	Target Neighborhood Hits	870	Shared Neighborhood Hits	53
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.064018 (rank : 505)
Query Neighborhood Hits	227	Target Neighborhood Hits	920	Shared Neighborhood Hits	53
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

L1CAM_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.071546 (rank : 451)
Query Neighborhood Hits	227	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.072447 (rank : 446)
Query Neighborhood Hits	227	Target Neighborhood Hits	457	Shared Neighborhood Hits	21
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LASP1_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.060223 (rank : 537)
Query Neighborhood Hits	227	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.059594 (rank : 544)
Query Neighborhood Hits	227	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LIFR_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.058571 (rank : 552)
Query Neighborhood Hits	227	Target Neighborhood Hits	127	Shared Neighborhood Hits	11
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

LIMK1_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.058836 (rank : 546)
Query Neighborhood Hits	227	Target Neighborhood Hits	1005	Shared Neighborhood Hits	51
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.058825 (rank : 547)
Query Neighborhood Hits	227	Target Neighborhood Hits	1008	Shared Neighborhood Hits	51
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.056952 (rank : 567)
Query Neighborhood Hits	227	Target Neighborhood Hits	986	Shared Neighborhood Hits	51
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.057612 (rank : 559)
Query Neighborhood Hits	227	Target Neighborhood Hits	998	Shared Neighborhood Hits	51
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRRK1_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.050122 (rank : 616)
Query Neighborhood Hits	227	Target Neighborhood Hits	1267	Shared Neighborhood Hits	49
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.091535 (rank : 297)
Query Neighborhood Hits	227	Target Neighborhood Hits	774	Shared Neighborhood Hits	49
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.090621 (rank : 302)
Query Neighborhood Hits	227	Target Neighborhood Hits	770	Shared Neighborhood Hits	49
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K10_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.075626 (rank : 419)
Query Neighborhood Hits	227	Target Neighborhood Hits	1071	Shared Neighborhood Hits	71
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.078397 (rank : 399)
Query Neighborhood Hits	227	Target Neighborhood Hits	1136	Shared Neighborhood Hits	71
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.063959 (rank : 506)
Query Neighborhood Hits	227	Target Neighborhood Hits	940	Shared Neighborhood Hits	51
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.063517 (rank : 508)
Query Neighborhood Hits	227	Target Neighborhood Hits	957	Shared Neighborhood Hits	51
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.062882 (rank : 512)
Query Neighborhood Hits	227	Target Neighborhood Hits	911	Shared Neighborhood Hits	49
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K7_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.060777 (rank : 534)
Query Neighborhood Hits	227	Target Neighborhood Hits	892	Shared Neighborhood Hits	51
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.060811 (rank : 533)
Query Neighborhood Hits	227	Target Neighborhood Hits	892	Shared Neighborhood Hits	51
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K9_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.076018 (rank : 416)
Query Neighborhood Hits	227	Target Neighborhood Hits	1123	Shared Neighborhood Hits	72
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.079503 (rank : 392)
Query Neighborhood Hits	227	Target Neighborhood Hits	1087	Shared Neighborhood Hits	73
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MAMC1_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.064928 (rank : 496)
Query Neighborhood Hits	227	Target Neighborhood Hits	357	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
θ value	θ > 10 (rank : 466)	NC score	0.066097 (rank : 486)
Query Neighborhood Hits	227	Target Neighborhood Hits	357	Shared Neighborhood Hits	11
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC2_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.087259 (rank : 323)
Query Neighborhood Hits	227	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAMC2_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.091015 (rank : 300)
Query Neighborhood Hits	227	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MDGA1_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.069245 (rank : 464)
Query Neighborhood Hits	227	Target Neighborhood Hits	358	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

MERL_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.089475 (rank : 311)
Query Neighborhood Hits	227	Target Neighborhood Hits	532	Shared Neighborhood Hits	15
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.089752 (rank : 310)
Query Neighborhood Hits	227	Target Neighborhood Hits	524	Shared Neighborhood Hits	15
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MERTK_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.106018 (rank : 226)
Query Neighborhood Hits	227	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.103708 (rank : 239)
Query Neighborhood Hits	227	Target Neighborhood Hits	974	Shared Neighborhood Hits	55
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.081211 (rank : 383)
Query Neighborhood Hits	227	Target Neighborhood Hits	831	Shared Neighborhood Hits	49
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.081541 (rank : 380)
Query Neighborhood Hits	227	Target Neighborhood Hits	844	Shared Neighborhood Hits	49
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLKL_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.076797 (rank : 413)
Query Neighborhood Hits	227	Target Neighborhood Hits	600	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.074750 (rank : 428)
Query Neighborhood Hits	227	Target Neighborhood Hits	707	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.067291 (rank : 477)
Query Neighborhood Hits	227	Target Neighborhood Hits	911	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.067232 (rank : 478)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOES_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.071786 (rank : 450)
Query Neighborhood Hits	227	Target Neighborhood Hits	892	Shared Neighborhood Hits	21
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.070794 (rank : 455)
Query Neighborhood Hits	227	Target Neighborhood Hits	923	Shared Neighborhood Hits	23
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOS_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.066516 (rank : 484)
Query Neighborhood Hits	227	Target Neighborhood Hits	829	Shared Neighborhood Hits	49
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.065528 (rank : 491)
Query Neighborhood Hits	227	Target Neighborhood Hits	833	Shared Neighborhood Hits	49
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MUSK_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.097173 (rank : 268)
Query Neighborhood Hits	227	Target Neighborhood Hits	1074	Shared Neighborhood Hits	55
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.096719 (rank : 272)
Query Neighborhood Hits	227	Target Neighborhood Hits	1057	Shared Neighborhood Hits	55
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYLIP_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.095192 (rank : 279)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.100066 (rank : 258)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLK_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.050098 (rank : 617)
Query Neighborhood Hits	227	Target Neighborhood Hits	1328	Shared Neighborhood Hits	61
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYOM1_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.059885 (rank : 540)
Query Neighborhood Hits	227	Target Neighborhood Hits	405	Shared Neighborhood Hits	12
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.064023 (rank : 504)
Query Neighborhood Hits	227	Target Neighborhood Hits	415	Shared Neighborhood Hits	15
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM2_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.055705 (rank : 577)
Query Neighborhood Hits	227	Target Neighborhood Hits	341	Shared Neighborhood Hits	15
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

NCF1_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.077859 (rank : 404)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.077729 (rank : 405)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.080760 (rank : 385)
Query Neighborhood Hits	227	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NEBL_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.058807 (rank : 548)
Query Neighborhood Hits	227	Target Neighborhood Hits	457	Shared Neighborhood Hits	54
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEO1_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.091372 (rank : 298)
Query Neighborhood Hits	227	Target Neighborhood Hits	530	Shared Neighborhood Hits	21
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.094255 (rank : 281)
Query Neighborhood Hits	227	Target Neighborhood Hits	523	Shared Neighborhood Hits	21
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NFASC_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.062369 (rank : 516)
Query Neighborhood Hits	227	Target Neighborhood Hits	497	Shared Neighborhood Hits	14
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.059969 (rank : 539)
Query Neighborhood Hits	227	Target Neighborhood Hits	475	Shared Neighborhood Hits	14
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NPHP1_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.103322 (rank : 242)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.113069 (rank : 205)
Query Neighborhood Hits	227	Target Neighborhood Hits	267	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NRCAM_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.069016 (rank : 470)
Query Neighborhood Hits	227	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.071132 (rank : 453)
Query Neighborhood Hits	227	Target Neighborhood Hits	432	Shared Neighborhood Hits	15
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NTRK1_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.084754 (rank : 357)
Query Neighborhood Hits	227	Target Neighborhood Hits	1023	Shared Neighborhood Hits	50
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.084996 (rank : 354)
Query Neighborhood Hits	227	Target Neighborhood Hits	1081	Shared Neighborhood Hits	53
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.084912 (rank : 356)
Query Neighborhood Hits	227	Target Neighborhood Hits	1088	Shared Neighborhood Hits	53
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.086621 (rank : 330)
Query Neighborhood Hits	227	Target Neighborhood Hits	1115	Shared Neighborhood Hits	53
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

OSTF1_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.078811 (rank : 395)
Query Neighborhood Hits	227	Target Neighborhood Hits	466	Shared Neighborhood Hits	50
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.074035 (rank : 434)
Query Neighborhood Hits	227	Target Neighborhood Hits	467	Shared Neighborhood Hits	50
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN1_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.072963 (rank : 441)
Query Neighborhood Hits	227	Target Neighborhood Hits	320	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.073050 (rank : 440)
Query Neighborhood Hits	227	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.075827 (rank : 418)
Query Neighborhood Hits	227	Target Neighborhood Hits	339	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.074074 (rank : 433)
Query Neighborhood Hits	227	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.069549 (rank : 462)
Query Neighborhood Hits	227	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.070330 (rank : 459)
Query Neighborhood Hits	227	Target Neighborhood Hits	380	Shared Neighborhood Hits	58
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PDC6I_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.050492 (rank : 613)
Query Neighborhood Hits	227	Target Neighborhood Hits	275	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

PEX13_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.052877 (rank : 599)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	31
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PGFRA_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.092288 (rank : 290)
Query Neighborhood Hits	227	Target Neighborhood Hits	980	Shared Neighborhood Hits	53
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.092780 (rank : 285)
Query Neighborhood Hits	227	Target Neighborhood Hits	975	Shared Neighborhood Hits	53
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.084580 (rank : 358)
Query Neighborhood Hits	227	Target Neighborhood Hits	962	Shared Neighborhood Hits	52
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.084465 (rank : 360)
Query Neighborhood Hits	227	Target Neighborhood Hits	960	Shared Neighborhood Hits	53
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PPIP1_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.081181 (rank : 384)
Query Neighborhood Hits	227	Target Neighborhood Hits	389	Shared Neighborhood Hits	63
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.078273 (rank : 402)
Query Neighborhood Hits	227	Target Neighborhood Hits	377	Shared Neighborhood Hits	60
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTEN_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.092220 (rank : 291)
Query Neighborhood Hits	227	Target Neighborhood Hits	72	Shared Neighborhood Hits	40
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.092220 (rank : 292)
Query Neighborhood Hits	227	Target Neighborhood Hits	73	Shared Neighborhood Hits	40
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

PTK7_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.089046 (rank : 315)
Query Neighborhood Hits	227	Target Neighborhood Hits	1103	Shared Neighborhood Hits	54
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PUNC_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.058452 (rank : 554)
Query Neighborhood Hits	227	Target Neighborhood Hits	449	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.053359 (rank : 594)
Query Neighborhood Hits	227	Target Neighborhood Hits	501	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

RADI_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.079742 (rank : 390)
Query Neighborhood Hits	227	Target Neighborhood Hits	741	Shared Neighborhood Hits	23
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.078328 (rank : 401)
Query Neighborhood Hits	227	Target Neighborhood Hits	773	Shared Neighborhood Hits	21
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

RAF1_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.068896 (rank : 471)
Query Neighborhood Hits	227	Target Neighborhood Hits	886	Shared Neighborhood Hits	57
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.068455 (rank : 473)
Query Neighborhood Hits	227	Target Neighborhood Hits	886	Shared Neighborhood Hits	57
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RES18_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.065914 (rank : 488)
Query Neighborhood Hits	227	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P47939	Gene names	Resp18
Domain Architecture	No domain graphic available
Description	Regulated endocrine-specific protein 18 precursor [Contains: Regulated endocrine-specific protein 18; Triskadecapeptide].

RET_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.082287 (rank : 377)
Query Neighborhood Hits	227	Target Neighborhood Hits	873	Shared Neighborhood Hits	49
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.081600 (rank : 379)
Query Neighborhood Hits	227	Target Neighborhood Hits	884	Shared Neighborhood Hits	49
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RHG04_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.057561 (rank : 562)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB2_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.068177 (rank : 474)
Query Neighborhood Hits	227	Target Neighborhood Hits	263	Shared Neighborhood Hits	31
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.070295 (rank : 460)
Query Neighborhood Hits	227	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIPK1_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.065777 (rank : 489)
Query Neighborhood Hits	227	Target Neighborhood Hits	891	Shared Neighborhood Hits	49
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.067035 (rank : 479)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	49
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.062192 (rank : 517)
Query Neighborhood Hits	227	Target Neighborhood Hits	774	Shared Neighborhood Hits	49
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.063489 (rank : 510)
Query Neighborhood Hits	227	Target Neighborhood Hits	776	Shared Neighborhood Hits	49
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.061827 (rank : 523)
Query Neighborhood Hits	227	Target Neighborhood Hits	828	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.061644 (rank : 524)
Query Neighborhood Hits	227	Target Neighborhood Hits	867	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK5_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.056984 (rank : 566)
Query Neighborhood Hits	227	Target Neighborhood Hits	864	Shared Neighborhood Hits	50
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.056875 (rank : 568)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	51
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

ROBO2_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.050008 (rank : 619)
Query Neighborhood Hits	227	Target Neighborhood Hits	479	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.050440 (rank : 615)
Query Neighborhood Hits	227	Target Neighborhood Hits	504	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.053228 (rank : 596)
Query Neighborhood Hits	227	Target Neighborhood Hits	570	Shared Neighborhood Hits	16
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ROBO3_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.059640 (rank : 543)
Query Neighborhood Hits	227	Target Neighborhood Hits	524	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

RON_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.082697 (rank : 374)
Query Neighborhood Hits	227	Target Neighborhood Hits	842	Shared Neighborhood Hits	49
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.084118 (rank : 365)
Query Neighborhood Hits	227	Target Neighborhood Hits	836	Shared Neighborhood Hits	49
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.088575 (rank : 317)
Query Neighborhood Hits	227	Target Neighborhood Hits	1018	Shared Neighborhood Hits	53
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.089408 (rank : 312)
Query Neighborhood Hits	227	Target Neighborhood Hits	1025	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.090390 (rank : 304)
Query Neighborhood Hits	227	Target Neighborhood Hits	1014	Shared Neighborhood Hits	55
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.093361 (rank : 284)
Query Neighborhood Hits	227	Target Neighborhood Hits	1000	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.108158 (rank : 218)
Query Neighborhood Hits	227	Target Neighborhood Hits	907	Shared Neighborhood Hits	63
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RYK_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.093549 (rank : 283)
Query Neighborhood Hits	227	Target Neighborhood Hits	701	Shared Neighborhood Hits	47
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.092717 (rank : 287)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	47
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SDK1_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.077511 (rank : 407)
Query Neighborhood Hits	227	Target Neighborhood Hits	511	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.079001 (rank : 394)
Query Neighborhood Hits	227	Target Neighborhood Hits	495	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.078491 (rank : 397)
Query Neighborhood Hits	227	Target Neighborhood Hits	495	Shared Neighborhood Hits	19
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.081475 (rank : 381)
Query Neighborhood Hits	227	Target Neighborhood Hits	480	Shared Neighborhood Hits	18
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SH3G1_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.055933 (rank : 575)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.058043 (rank : 556)
Query Neighborhood Hits	227	Target Neighborhood Hits	291	Shared Neighborhood Hits	50
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.060230 (rank : 536)
Query Neighborhood Hits	227	Target Neighborhood Hits	324	Shared Neighborhood Hits	51
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.055333 (rank : 581)
Query Neighborhood Hits	227	Target Neighborhood Hits	319	Shared Neighborhood Hits	45
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.056422 (rank : 571)
Query Neighborhood Hits	227	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.061159 (rank : 529)
Query Neighborhood Hits	227	Target Neighborhood Hits	236	Shared Neighborhood Hits	47
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.078556 (rank : 396)
Query Neighborhood Hits	227	Target Neighborhood Hits	341	Shared Neighborhood Hits	49
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.079317 (rank : 393)
Query Neighborhood Hits	227	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SOCS5_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.062611 (rank : 513)
Query Neighborhood Hits	227	Target Neighborhood Hits	91	Shared Neighborhood Hits	66
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.061983 (rank : 522)
Query Neighborhood Hits	227	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SOCS6_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.127822 (rank : 192)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	89
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.129619 (rank : 188)
Query Neighborhood Hits	227	Target Neighborhood Hits	146	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.131664 (rank : 186)
Query Neighborhood Hits	227	Target Neighborhood Hits	154	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPN90_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.078342 (rank : 400)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.071012 (rank : 454)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.084070 (rank : 367)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.084326 (rank : 362)
Query Neighborhood Hits	227	Target Neighborhood Hits	409	Shared Neighborhood Hits	56
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.076990 (rank : 412)
Query Neighborhood Hits	227	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.075114 (rank : 425)
Query Neighborhood Hits	227	Target Neighborhood Hits	292	Shared Neighborhood Hits	53
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.051849 (rank : 607)
Query Neighborhood Hits	227	Target Neighborhood Hits	390	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.056116 (rank : 573)
Query Neighborhood Hits	227	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 585)	NC score	0.055404 (rank : 580)
Query Neighborhood Hits	227	Target Neighborhood Hits	324	Shared Neighborhood Hits	56
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.095754 (rank : 277)
Query Neighborhood Hits	227	Target Neighborhood Hits	228	Shared Neighborhood Hits	54
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.096213 (rank : 274)
Query Neighborhood Hits	227	Target Neighborhood Hits	232	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.085565 (rank : 344)
Query Neighborhood Hits	227	Target Neighborhood Hits	276	Shared Neighborhood Hits	55
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 589)	NC score	0.090449 (rank : 303)
Query Neighborhood Hits	227	Target Neighborhood Hits	268	Shared Neighborhood Hits	53
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.084368 (rank : 361)
Query Neighborhood Hits	227	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 591)	NC score	0.084285 (rank : 363)
Query Neighborhood Hits	227	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.085962 (rank : 336)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.086760 (rank : 328)
Query Neighborhood Hits	227	Target Neighborhood Hits	285	Shared Neighborhood Hits	50
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STYK1_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.092683 (rank : 288)
Query Neighborhood Hits	227	Target Neighborhood Hits	786	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.091782 (rank : 295)
Query Neighborhood Hits	227	Target Neighborhood Hits	779	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TARSH_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.064209 (rank : 501)
Query Neighborhood Hits	227	Target Neighborhood Hits	768	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TENA_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.063065 (rank : 511)
Query Neighborhood Hits	227	Target Neighborhood Hits	631	Shared Neighborhood Hits	19
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENA_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.057328 (rank : 565)
Query Neighborhood Hits	227	Target Neighborhood Hits	596	Shared Neighborhood Hits	17
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

TENN_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.074516 (rank : 430)
Query Neighborhood Hits	227	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TENN_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.088105 (rank : 319)
Query Neighborhood Hits	227	Target Neighborhood Hits	484	Shared Neighborhood Hits	19
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TENR_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.073634 (rank : 435)
Query Neighborhood Hits	227	Target Neighborhood Hits	526	Shared Neighborhood Hits	17
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

TENR_MOUSE
θ value	θ > 10 (rank : 602)	NC score	0.073358 (rank : 438)
Query Neighborhood Hits	227	Target Neighborhood Hits	531	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

TESK1_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.056230 (rank : 572)
Query Neighborhood Hits	227	Target Neighborhood Hits	864	Shared Neighborhood Hits	50
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.055867 (rank : 576)
Query Neighborhood Hits	227	Target Neighborhood Hits	862	Shared Neighborhood Hits	49
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.058621 (rank : 551)
Query Neighborhood Hits	227	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.057794 (rank : 558)
Query Neighborhood Hits	227	Target Neighborhood Hits	833	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.075380 (rank : 421)
Query Neighborhood Hits	227	Target Neighborhood Hits	1103	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.073075 (rank : 439)
Query Neighborhood Hits	227	Target Neighborhood Hits	1333	Shared Neighborhood Hits	54
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.056788 (rank : 569)
Query Neighborhood Hits	227	Target Neighborhood Hits	755	Shared Neighborhood Hits	49
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.056713 (rank : 570)
Query Neighborhood Hits	227	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TIE1_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.108121 (rank : 219)
Query Neighborhood Hits	227	Target Neighborhood Hits	1241	Shared Neighborhood Hits	65
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.112592 (rank : 207)
Query Neighborhood Hits	227	Target Neighborhood Hits	1266	Shared Neighborhood Hits	65
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.106691 (rank : 221)
Query Neighborhood Hits	227	Target Neighborhood Hits	1192	Shared Neighborhood Hits	63
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.109081 (rank : 214)
Query Neighborhood Hits	227	Target Neighborhood Hits	1204	Shared Neighborhood Hits	62
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TITIN_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.061002 (rank : 531)
Query Neighborhood Hits	227	Target Neighborhood Hits	2923	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TNI3K_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.054120 (rank : 587)
Query Neighborhood Hits	227	Target Neighborhood Hits	1084	Shared Neighborhood Hits	49
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.054237 (rank : 586)
Query Neighborhood Hits	227	Target Neighborhood Hits	1079	Shared Neighborhood Hits	49
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNK1_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.086567 (rank : 331)
Query Neighborhood Hits	227	Target Neighborhood Hits	815	Shared Neighborhood Hits	53
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 619)	NC score	0.086009 (rank : 335)
Query Neighborhood Hits	227	Target Neighborhood Hits	806	Shared Neighborhood Hits	56
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.057572 (rank : 561)
Query Neighborhood Hits	227	Target Neighborhood Hits	605	Shared Neighborhood Hits	47
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.057590 (rank : 560)
Query Neighborhood Hits	227	Target Neighborhood Hits	618	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.074877 (rank : 426)
Query Neighborhood Hits	227	Target Neighborhood Hits	841	Shared Neighborhood Hits	49
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.076303 (rank : 415)
Query Neighborhood Hits	227	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.101084 (rank : 255)
Query Neighborhood Hits	227	Target Neighborhood Hits	995	Shared Neighborhood Hits	54
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.102882 (rank : 245)
Query Neighborhood Hits	227	Target Neighborhood Hits	1007	Shared Neighborhood Hits	56
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.106469 (rank : 222)
Query Neighborhood Hits	227	Target Neighborhood Hits	981	Shared Neighborhood Hits	61
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.102041 (rank : 250)
Query Neighborhood Hits	227	Target Neighborhood Hits	988	Shared Neighborhood Hits	57
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

USH2A_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.079557 (rank : 391)
Query Neighborhood Hits	227	Target Neighborhood Hits	600	Shared Neighborhood Hits	21
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

USH2A_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.076747 (rank : 414)
Query Neighborhood Hits	227	Target Neighborhood Hits	626	Shared Neighborhood Hits	20
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VGFR1_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.080572 (rank : 386)
Query Neighborhood Hits	227	Target Neighborhood Hits	1109	Shared Neighborhood Hits	53
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.082015 (rank : 378)
Query Neighborhood Hits	227	Target Neighborhood Hits	1118	Shared Neighborhood Hits	54
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.086693 (rank : 329)
Query Neighborhood Hits	227	Target Neighborhood Hits	1103	Shared Neighborhood Hits	53
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.085169 (rank : 352)
Query Neighborhood Hits	227	Target Neighborhood Hits	1089	Shared Neighborhood Hits	54
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.081282 (rank : 382)
Query Neighborhood Hits	227	Target Neighborhood Hits	1037	Shared Neighborhood Hits	53
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 635)	NC score	0.080456 (rank : 387)
Query Neighborhood Hits	227	Target Neighborhood Hits	1056	Shared Neighborhood Hits	53
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VINEX_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.084543 (rank : 359)
Query Neighborhood Hits	227	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.085351 (rank : 349)
Query Neighborhood Hits	227	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

PTN11_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	227
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
NC score	0.999942 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	226
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_MOUSE
NC score	0.990528 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	200
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN6_HUMAN
NC score	0.988375 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	227	Target Neighborhood Hits	234	Shared Neighborhood Hits	193
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN1_MOUSE
NC score	0.888576 (rank : 5)	θ value	9.81109e-47 (rank : 22)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN1_HUMAN
NC score	0.888249 (rank : 6)	θ value	1.28137e-46 (rank : 23)
Query Neighborhood Hits	227	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN18_HUMAN
NC score	0.887603 (rank : 7)	θ value	5.57106e-42 (rank : 40)
Query Neighborhood Hits	227	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN2_HUMAN
NC score	0.886655 (rank : 8)	θ value	5.38352e-45 (rank : 30)
Query Neighborhood Hits	227	Target Neighborhood Hits	92	Shared Neighborhood Hits	64
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
NC score	0.886596 (rank : 9)	θ value	1.56636e-44 (rank : 32)
Query Neighborhood Hits	227	Target Neighborhood Hits	107	Shared Neighborhood Hits	65
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN7_HUMAN
NC score	0.886031 (rank : 10)	θ value	2.58786e-39 (rank : 53)
Query Neighborhood Hits	227	Target Neighborhood Hits	75	Shared Neighborhood Hits	67
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN18_MOUSE
NC score	0.885965 (rank : 11)	θ value	1.2411e-41 (rank : 42)
Query Neighborhood Hits	227	Target Neighborhood Hits	134	Shared Neighborhood Hits	74
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN7_MOUSE
NC score	0.885915 (rank : 12)	θ value	1.6774e-38 (rank : 57)
Query Neighborhood Hits	227	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN5_MOUSE
NC score	0.882518 (rank : 13)	θ value	3.48949e-44 (rank : 34)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_HUMAN
NC score	0.881960 (rank : 14)	θ value	4.2656e-42 (rank : 37)
Query Neighborhood Hits	227	Target Neighborhood Hits	80	Shared Neighborhood Hits	71
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN12_HUMAN
NC score	0.880775 (rank : 15)	θ value	1.56636e-44 (rank : 31)
Query Neighborhood Hits	227	Target Neighborhood Hits	102	Shared Neighborhood Hits	68
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
NC score	0.880708 (rank : 16)	θ value	1.41672e-45 (rank : 26)
Query Neighborhood Hits	227	Target Neighborhood Hits	123	Shared Neighborhood Hits	67
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN22_HUMAN
NC score	0.879745 (rank : 17)	θ value	4.55743e-44 (rank : 35)
Query Neighborhood Hits	227	Target Neighborhood Hits	109	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTPRR_HUMAN
NC score	0.875887 (rank : 18)	θ value	2.50074e-42 (rank : 36)
Query Neighborhood Hits	227	Target Neighborhood Hits	77	Shared Neighborhood Hits	67
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
NC score	0.875823 (rank : 19)	θ value	9.50281e-42 (rank : 41)
Query Neighborhood Hits	227	Target Neighborhood Hits	84	Shared Neighborhood Hits	69
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRE_MOUSE
NC score	0.873465 (rank : 20)	θ value	1.32293e-51 (rank : 9)
Query Neighborhood Hits	227	Target Neighborhood Hits	86	Shared Neighborhood Hits	71
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRO_HUMAN
NC score	0.873343 (rank : 21)	θ value	2.11701e-41 (rank : 44)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	71
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRE_HUMAN
NC score	0.873285 (rank : 22)	θ value	1.11993e-50 (rank : 12)
Query Neighborhood Hits	227	Target Neighborhood Hits	92	Shared Neighborhood Hits	71
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTN22_MOUSE
NC score	0.872580 (rank : 23)	θ value	2.76489e-41 (rank : 45)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	65
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTPRA_HUMAN
NC score	0.871823 (rank : 24)	θ value	2.49495e-50 (rank : 13)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	69
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPR2_HUMAN
NC score	0.870569 (rank : 25)	θ value	6.15952e-41 (rank : 46)
Query Neighborhood Hits	227	Target Neighborhood Hits	103	Shared Neighborhood Hits	67
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPRA_MOUSE
NC score	0.869688 (rank : 26)	θ value	6.35935e-46 (rank : 25)
Query Neighborhood Hits	227	Target Neighborhood Hits	93	Shared Neighborhood Hits	69
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPR2_MOUSE
NC score	0.868883 (rank : 27)	θ value	1.05066e-40 (rank : 47)
Query Neighborhood Hits	227	Target Neighborhood Hits	120	Shared Neighborhood Hits	67
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTN9_MOUSE
NC score	0.868345 (rank : 28)	θ value	2.58786e-39 (rank : 54)
Query Neighborhood Hits	227	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_HUMAN
NC score	0.868128 (rank : 29)	θ value	6.81017e-40 (rank : 50)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	67
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

CD45_MOUSE
NC score	0.867692 (rank : 30)	θ value	1.3722e-40 (rank : 48)
Query Neighborhood Hits	227	Target Neighborhood Hits	178	Shared Neighborhood Hits	65
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTPRN_HUMAN
NC score	0.864863 (rank : 31)	θ value	5.21438e-40 (rank : 49)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	68
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

CD45_HUMAN
NC score	0.863088 (rank : 32)	θ value	5.57106e-42 (rank : 39)
Query Neighborhood Hits	227	Target Neighborhood Hits	243	Shared Neighborhood Hits	66
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

PTPRN_MOUSE
NC score	0.860376 (rank : 33)	θ value	3.37985e-39 (rank : 56)
Query Neighborhood Hits	227	Target Neighborhood Hits	240	Shared Neighborhood Hits	67
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRJ_MOUSE
NC score	0.848632 (rank : 34)	θ value	2.18568e-46 (rank : 24)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	71
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRJ_HUMAN
NC score	0.844012 (rank : 35)	θ value	1.85029e-45 (rank : 27)
Query Neighborhood Hits	227	Target Neighborhood Hits	207	Shared Neighborhood Hits	72
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRV_MOUSE
NC score	0.838930 (rank : 36)	θ value	2.04573e-44 (rank : 33)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	67
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRK_HUMAN
NC score	0.818841 (rank : 37)	θ value	1.41344e-53 (rank : 7)
Query Neighborhood Hits	227	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
NC score	0.816939 (rank : 38)	θ value	1.41344e-53 (rank : 8)
Query Neighborhood Hits	227	Target Neighborhood Hits	223	Shared Neighborhood Hits	67
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRB_HUMAN
NC score	0.814866 (rank : 39)	θ value	2.58187e-47 (rank : 18)
Query Neighborhood Hits	227	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRT_MOUSE
NC score	0.813371 (rank : 40)	θ value	1.08223e-53 (rank : 6)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	67
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRT_HUMAN
NC score	0.813369 (rank : 41)	θ value	1.08223e-53 (rank : 5)
Query Neighborhood Hits	227	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRU_HUMAN
NC score	0.802928 (rank : 42)	θ value	4.2656e-42 (rank : 38)
Query Neighborhood Hits	227	Target Neighborhood Hits	237	Shared Neighborhood Hits	67
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRM_MOUSE
NC score	0.800268 (rank : 43)	θ value	2.25659e-51 (rank : 10)
Query Neighborhood Hits	227	Target Neighborhood Hits	238	Shared Neighborhood Hits	68
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_HUMAN
NC score	0.798381 (rank : 44)	θ value	2.94719e-51 (rank : 11)
Query Neighborhood Hits	227	Target Neighborhood Hits	244	Shared Neighborhood Hits	68
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRZ_HUMAN
NC score	0.788962 (rank : 45)	θ value	5.7518e-47 (rank : 20)
Query Neighborhood Hits	227	Target Neighborhood Hits	255	Shared Neighborhood Hits	65
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTPRG_HUMAN
NC score	0.788719 (rank : 46)	θ value	7.25919e-50 (rank : 15)
Query Neighborhood Hits	227	Target Neighborhood Hits	231	Shared Neighborhood Hits	65
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
NC score	0.785528 (rank : 47)	θ value	4.25575e-50 (rank : 14)
Query Neighborhood Hits	227	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTN23_HUMAN
NC score	0.752602 (rank : 48)	θ value	2.86786e-30 (rank : 60)
Query Neighborhood Hits	227	Target Neighborhood Hits	646	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
NC score	0.751428 (rank : 49)	θ value	6.38894e-30 (rank : 61)
Query Neighborhood Hits	227	Target Neighborhood Hits	726	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN14_HUMAN
NC score	0.747171 (rank : 50)	θ value	2.86122e-38 (rank : 58)
Query Neighborhood Hits	227	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN14_MOUSE
NC score	0.741760 (rank : 51)	θ value	8.32485e-38 (rank : 59)
Query Neighborhood Hits	227	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN21_HUMAN
NC score	0.735316 (rank : 52)	θ value	2.58786e-39 (rank : 52)
Query Neighborhood Hits	227	Target Neighborhood Hits	143	Shared Neighborhood Hits	64
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN21_MOUSE
NC score	0.733569 (rank : 53)	θ value	3.37985e-39 (rank : 55)
Query Neighborhood Hits	227	Target Neighborhood Hits	155	Shared Neighborhood Hits	62
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN3_HUMAN
NC score	0.700870 (rank : 54)	θ value	1.51715e-39 (rank : 51)
Query Neighborhood Hits	227	Target Neighborhood Hits	258	Shared Neighborhood Hits	69
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN4_HUMAN
NC score	0.678794 (rank : 55)	θ value	1.62093e-41 (rank : 43)
Query Neighborhood Hits	227	Target Neighborhood Hits	303	Shared Neighborhood Hits	73
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN13_MOUSE
NC score	0.667848 (rank : 56)	θ value	2.41655e-45 (rank : 28)
Query Neighborhood Hits	227	Target Neighborhood Hits	426	Shared Neighborhood Hits	73
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN13_HUMAN
NC score	0.662234 (rank : 57)	θ value	3.15612e-45 (rank : 29)
Query Neighborhood Hits	227	Target Neighborhood Hits	471	Shared Neighborhood Hits	71
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTPRS_HUMAN
NC score	0.634921 (rank : 58)	θ value	1.04822e-48 (rank : 17)
Query Neighborhood Hits	227	Target Neighborhood Hits	472	Shared Neighborhood Hits	74
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRD_HUMAN
NC score	0.622914 (rank : 59)	θ value	8.02596e-49 (rank : 16)
Query Neighborhood Hits	227	Target Neighborhood Hits	485	Shared Neighborhood Hits	74
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
NC score	0.619783 (rank : 60)	θ value	7.51208e-47 (rank : 21)
Query Neighborhood Hits	227	Target Neighborhood Hits	489	Shared Neighborhood Hits	73
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRD_MOUSE
NC score	0.613153 (rank : 61)	θ value	5.7518e-47 (rank : 19)
Query Neighborhood Hits	227	Target Neighborhood Hits	491	Shared Neighborhood Hits	74
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

DAPP1_HUMAN
NC score	0.349013 (rank : 62)	θ value	5.62301e-10 (rank : 69)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.342127 (rank : 63)	θ value	2.13673e-09 (rank : 71)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	136
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GRAP_HUMAN
NC score	0.339688 (rank : 64)	θ value	1.17247e-07 (rank : 84)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	126
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.338365 (rank : 65)	θ value	3.41135e-07 (rank : 90)
Query Neighborhood Hits	227	Target Neighborhood Hits	309	Shared Neighborhood Hits	126
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.333199 (rank : 66)	θ value	8.67504e-11 (rank : 65)
Query Neighborhood Hits	227	Target Neighborhood Hits	310	Shared Neighborhood Hits	136
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.330312 (rank : 67)	θ value	1.9326e-10 (rank : 66)
Query Neighborhood Hits	227	Target Neighborhood Hits	312	Shared Neighborhood Hits	131
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP2_HUMAN
NC score	0.329276 (rank : 68)	θ value	3.29651e-10 (rank : 67)
Query Neighborhood Hits	227	Target Neighborhood Hits	304	Shared Neighborhood Hits	121
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRB2_MOUSE
NC score	0.325592 (rank : 69)	θ value	1.99992e-07 (rank : 89)
Query Neighborhood Hits	227	Target Neighborhood Hits	312	Shared Neighborhood Hits	132
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.325333 (rank : 70)	θ value	1.99992e-07 (rank : 88)
Query Neighborhood Hits	227	Target Neighborhood Hits	310	Shared Neighborhood Hits	132
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

PLCG1_HUMAN
NC score	0.322278 (rank : 71)	θ value	1.058e-16 (rank : 63)
Query Neighborhood Hits	227	Target Neighborhood Hits	293	Shared Neighborhood Hits	133
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

GRAP2_MOUSE
NC score	0.322189 (rank : 72)	θ value	2.13673e-09 (rank : 72)
Query Neighborhood Hits	227	Target Neighborhood Hits	297	Shared Neighborhood Hits	121
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PLCG1_MOUSE
NC score	0.320571 (rank : 73)	θ value	1.63225e-17 (rank : 62)
Query Neighborhood Hits	227	Target Neighborhood Hits	314	Shared Neighborhood Hits	133
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH21B_HUMAN
NC score	0.319147 (rank : 74)	θ value	4.1701e-05 (rank : 133)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	98
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PLCG2_HUMAN
NC score	0.317544 (rank : 75)	θ value	1.38178e-16 (rank : 64)
Query Neighborhood Hits	227	Target Neighborhood Hits	280	Shared Neighborhood Hits	126
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SLAP2_HUMAN
NC score	0.314378 (rank : 76)	θ value	0.00102713 (rank : 159)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

RASA1_HUMAN
NC score	0.307944 (rank : 77)	θ value	4.30538e-10 (rank : 68)
Query Neighborhood Hits	227	Target Neighborhood Hits	258	Shared Neighborhood Hits	128
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SLAP2_MOUSE
NC score	0.307933 (rank : 78)	θ value	0.0330416 (rank : 180)
Query Neighborhood Hits	227	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

GRB14_MOUSE
NC score	0.299971 (rank : 79)	θ value	1.38499e-08 (rank : 75)
Query Neighborhood Hits	227	Target Neighborhood Hits	149	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SH21B_MOUSE
NC score	0.293388 (rank : 80)	θ value	0.0113563 (rank : 170)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	93
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

GRB14_HUMAN
NC score	0.293144 (rank : 81)	θ value	5.26297e-08 (rank : 81)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	114
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHC1_MOUSE
NC score	0.292195 (rank : 82)	θ value	2.21117e-06 (rank : 102)
Query Neighborhood Hits	227	Target Neighborhood Hits	180	Shared Neighborhood Hits	125
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_HUMAN
NC score	0.290818 (rank : 83)	θ value	2.88788e-06 (rank : 104)
Query Neighborhood Hits	227	Target Neighborhood Hits	170	Shared Neighborhood Hits	123
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

CRKL_MOUSE
NC score	0.289669 (rank : 84)	θ value	1.43324e-05 (rank : 121)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.289388 (rank : 85)	θ value	6.43352e-06 (rank : 111)
Query Neighborhood Hits	227	Target Neighborhood Hits	313	Shared Neighborhood Hits	128
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SHD_MOUSE
NC score	0.285919 (rank : 86)	θ value	8.40245e-06 (rank : 116)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	120
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

CRK_HUMAN
NC score	0.285062 (rank : 87)	θ value	2.44474e-05 (rank : 126)
Query Neighborhood Hits	227	Target Neighborhood Hits	308	Shared Neighborhood Hits	131
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SHC3_MOUSE
NC score	0.285010 (rank : 88)	θ value	1.09739e-05 (rank : 117)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	121
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHC3_HUMAN
NC score	0.281981 (rank : 89)	θ value	2.21117e-06 (rank : 103)
Query Neighborhood Hits	227	Target Neighborhood Hits	155	Shared Neighborhood Hits	117
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SLAP1_HUMAN
NC score	0.281595 (rank : 90)	θ value	0.125558 (rank : 186)
Query Neighborhood Hits	227	Target Neighborhood Hits	113	Shared Neighborhood Hits	107
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SHD_HUMAN
NC score	0.281507 (rank : 91)	θ value	4.1701e-05 (rank : 135)
Query Neighborhood Hits	227	Target Neighborhood Hits	204	Shared Neighborhood Hits	117
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SLAP1_MOUSE
NC score	0.281494 (rank : 92)	θ value	0.163984 (rank : 189)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	107
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

DUS23_MOUSE
NC score	0.281352 (rank : 93)	θ value	5.27518 (rank : 223)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	58
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

APS_HUMAN
NC score	0.281149 (rank : 94)	θ value	0.000786445 (rank : 153)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	111
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CRK_MOUSE
NC score	0.281003 (rank : 95)	θ value	2.44474e-05 (rank : 127)
Query Neighborhood Hits	227	Target Neighborhood Hits	314	Shared Neighborhood Hits	131
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

LNK_MOUSE
NC score	0.280978 (rank : 96)	θ value	0.00035302 (rank : 147)
Query Neighborhood Hits	227	Target Neighborhood Hits	132	Shared Neighborhood Hits	111
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHB_MOUSE
NC score	0.280279 (rank : 97)	θ value	4.1701e-05 (rank : 134)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	122
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_HUMAN
NC score	0.279816 (rank : 98)	θ value	2.44474e-05 (rank : 128)
Query Neighborhood Hits	227	Target Neighborhood Hits	141	Shared Neighborhood Hits	121
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC2_MOUSE
NC score	0.279656 (rank : 99)	θ value	0.000270298 (rank : 145)
Query Neighborhood Hits	227	Target Neighborhood Hits	144	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.278480 (rank : 100)	θ value	0.000602161 (rank : 152)
Query Neighborhood Hits	227	Target Neighborhood Hits	170	Shared Neighborhood Hits	122
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

GRB7_MOUSE
NC score	0.277202 (rank : 101)	θ value	8.40245e-06 (rank : 114)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	120
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LNK_HUMAN
NC score	0.276326 (rank : 102)	θ value	0.000786445 (rank : 155)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SH21A_MOUSE
NC score	0.274336 (rank : 103)	θ value	0.00869519 (rank : 168)
Query Neighborhood Hits	227	Target Neighborhood Hits	89	Shared Neighborhood Hits	88
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

DUS23_HUMAN
NC score	0.272774 (rank : 104)	θ value	1.06291 (rank : 201)
Query Neighborhood Hits	227	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

HSH2D_HUMAN
NC score	0.272588 (rank : 105)	θ value	0.00298849 (rank : 163)
Query Neighborhood Hits	227	Target Neighborhood Hits	159	Shared Neighborhood Hits	118
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SH21A_HUMAN
NC score	0.271472 (rank : 106)	θ value	0.00509761 (rank : 165)
Query Neighborhood Hits	227	Target Neighborhood Hits	89	Shared Neighborhood Hits	87
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

GRB7_HUMAN
NC score	0.267081 (rank : 107)	θ value	3.77169e-06 (rank : 109)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	117
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SHE_MOUSE
NC score	0.261384 (rank : 108)	θ value	0.125558 (rank : 185)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_HUMAN
NC score	0.254014 (rank : 109)	θ value	0.365318 (rank : 193)
Query Neighborhood Hits	227	Target Neighborhood Hits	164	Shared Neighborhood Hits	123
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

GRB10_HUMAN
NC score	0.249627 (rank : 110)	θ value	4.1701e-05 (rank : 130)
Query Neighborhood Hits	227	Target Neighborhood Hits	147	Shared Neighborhood Hits	113
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
NC score	0.249097 (rank : 111)	θ value	4.1701e-05 (rank : 131)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	112
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

APS_MOUSE
NC score	0.242016 (rank : 112)	θ value	0.00390308 (rank : 164)
Query Neighborhood Hits	227	Target Neighborhood Hits	134	Shared Neighborhood Hits	95
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

BCAR3_HUMAN
NC score	0.240256 (rank : 113)	θ value	1.29631e-06 (rank : 99)
Query Neighborhood Hits	227	Target Neighborhood Hits	129	Shared Neighborhood Hits	94
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

VAV3_HUMAN
NC score	0.239865 (rank : 114)	θ value	2.88788e-06 (rank : 105)
Query Neighborhood Hits	227	Target Neighborhood Hits	398	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.239287 (rank : 115)	θ value	2.88788e-06 (rank : 106)
Query Neighborhood Hits	227	Target Neighborhood Hits	404	Shared Neighborhood Hits	116
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

P55G_MOUSE
NC score	0.237020 (rank : 116)	θ value	0.00035302 (rank : 148)
Query Neighborhood Hits	227	Target Neighborhood Hits	401	Shared Neighborhood Hits	117
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH24A_HUMAN
NC score	0.236950 (rank : 117)	θ value	6.43352e-06 (rank : 113)
Query Neighborhood Hits	227	Target Neighborhood Hits	455	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

P55G_HUMAN
NC score	0.236931 (rank : 118)	θ value	0.00102713 (rank : 157)
Query Neighborhood Hits	227	Target Neighborhood Hits	451	Shared Neighborhood Hits	120
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

BCAR3_MOUSE
NC score	0.234873 (rank : 119)	θ value	1.87187e-05 (rank : 123)
Query Neighborhood Hits	227	Target Neighborhood Hits	127	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SH2D3_MOUSE
NC score	0.232206 (rank : 120)	θ value	0.00228821 (rank : 162)
Query Neighborhood Hits	227	Target Neighborhood Hits	174	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

VAV2_HUMAN
NC score	0.231013 (rank : 121)	θ value	5.81887e-07 (rank : 94)
Query Neighborhood Hits	227	Target Neighborhood Hits	453	Shared Neighborhood Hits	124
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SH2D3_HUMAN
NC score	0.230744 (rank : 122)	θ value	0.00175202 (rank : 160)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

VAV2_MOUSE
NC score	0.227912 (rank : 123)	θ value	5.81887e-07 (rank : 95)
Query Neighborhood Hits	227	Target Neighborhood Hits	456	Shared Neighborhood Hits	121
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
NC score	0.219891 (rank : 124)	θ value	4.1701e-05 (rank : 136)
Query Neighborhood Hits	227	Target Neighborhood Hits	452	Shared Neighborhood Hits	114
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SH23A_HUMAN
NC score	0.217862 (rank : 125)	θ value	0.0148317 (rank : 172)
Query Neighborhood Hits	227	Target Neighborhood Hits	149	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

P85B_MOUSE
NC score	0.213614 (rank : 126)	θ value	0.0148317 (rank : 171)
Query Neighborhood Hits	227	Target Neighborhood Hits	519	Shared Neighborhood Hits	129
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_HUMAN
NC score	0.212923 (rank : 127)	θ value	0.0330416 (rank : 178)
Query Neighborhood Hits	227	Target Neighborhood Hits	543	Shared Neighborhood Hits	133
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85A_MOUSE
NC score	0.209906 (rank : 128)	θ value	0.00665767 (rank : 166)
Query Neighborhood Hits	227	Target Neighborhood Hits	435	Shared Neighborhood Hits	124
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SH24A_MOUSE
NC score	0.208099 (rank : 129)	θ value	0.000270298 (rank : 144)
Query Neighborhood Hits	227	Target Neighborhood Hits	326	Shared Neighborhood Hits	89
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

VAV_MOUSE
NC score	0.207596 (rank : 130)	θ value	0.000121331 (rank : 139)
Query Neighborhood Hits	227	Target Neighborhood Hits	430	Shared Neighborhood Hits	108
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

HSH2D_MOUSE
NC score	0.206320 (rank : 131)	θ value	0.0961366 (rank : 183)
Query Neighborhood Hits	227	Target Neighborhood Hits	124	Shared Neighborhood Hits	101
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

LCP2_MOUSE
NC score	0.206066 (rank : 132)	θ value	0.000158464 (rank : 141)
Query Neighborhood Hits	227	Target Neighborhood Hits	177	Shared Neighborhood Hits	76
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

P85A_HUMAN
NC score	0.204845 (rank : 133)	θ value	0.00869519 (rank : 167)
Query Neighborhood Hits	227	Target Neighborhood Hits	479	Shared Neighborhood Hits	121
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SH22A_MOUSE
NC score	0.204601 (rank : 134)	θ value	0.0330416 (rank : 179)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH22A_HUMAN
NC score	0.190315 (rank : 135)	θ value	0.125558 (rank : 184)
Query Neighborhood Hits	227	Target Neighborhood Hits	144	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

FGR_MOUSE
NC score	0.175429 (rank : 136)	θ value	1.63604e-09 (rank : 70)
Query Neighborhood Hits	227	Target Neighborhood Hits	1069	Shared Neighborhood Hits	142
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LCP2_HUMAN
NC score	0.168094 (rank : 137)	θ value	0.00228821 (rank : 161)
Query Neighborhood Hits	227	Target Neighborhood Hits	531	Shared Neighborhood Hits	78
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

FGR_HUMAN
NC score	0.167392 (rank : 138)	θ value	1.29631e-06 (rank : 100)
Query Neighborhood Hits	227	Target Neighborhood Hits	1067	Shared Neighborhood Hits	138
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_HUMAN
NC score	0.164897 (rank : 139)	θ value	1.06045e-08 (rank : 73)
Query Neighborhood Hits	227	Target Neighborhood Hits	1059	Shared Neighborhood Hits	125
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ABL2_HUMAN
NC score	0.164612 (rank : 140)	θ value	1.38499e-08 (rank : 74)
Query Neighborhood Hits	227	Target Neighborhood Hits	1045	Shared Neighborhood Hits	138
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

YES_MOUSE
NC score	0.164273 (rank : 141)	θ value	1.17247e-07 (rank : 85)
Query Neighborhood Hits	227	Target Neighborhood Hits	1052	Shared Neighborhood Hits	125
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.162843 (rank : 142)	θ value	8.97725e-08 (rank : 83)
Query Neighborhood Hits	227	Target Neighborhood Hits	1073	Shared Neighborhood Hits	130
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ABL1_HUMAN
NC score	0.161997 (rank : 143)	θ value	6.87365e-08 (rank : 82)
Query Neighborhood Hits	227	Target Neighborhood Hits	1220	Shared Neighborhood Hits	138
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SRC_MOUSE
NC score	0.161870 (rank : 144)	θ value	1.09739e-05 (rank : 119)
Query Neighborhood Hits	227	Target Neighborhood Hits	1033	Shared Neighborhood Hits	134
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ABL1_MOUSE
NC score	0.161729 (rank : 145)	θ value	5.26297e-08 (rank : 79)
Query Neighborhood Hits	227	Target Neighborhood Hits	1178	Shared Neighborhood Hits	138
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FYN_HUMAN
NC score	0.161510 (rank : 146)	θ value	1.99992e-07 (rank : 87)
Query Neighborhood Hits	227	Target Neighborhood Hits	1078	Shared Neighborhood Hits	136
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRC_HUMAN
NC score	0.161286 (rank : 147)	θ value	1.09739e-05 (rank : 118)
Query Neighborhood Hits	227	Target Neighborhood Hits	1058	Shared Neighborhood Hits	134
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

CSK_HUMAN
NC score	0.158961 (rank : 148)	θ value	1.99992e-07 (rank : 86)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	138
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.158700 (rank : 149)	θ value	4.45536e-07 (rank : 92)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	138
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

LCK_HUMAN
NC score	0.157925 (rank : 150)	θ value	1.29631e-06 (rank : 101)
Query Neighborhood Hits	227	Target Neighborhood Hits	987	Shared Neighborhood Hits	123
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

HCK_HUMAN
NC score	0.157706 (rank : 151)	θ value	6.43352e-06 (rank : 112)
Query Neighborhood Hits	227	Target Neighborhood Hits	1035	Shared Neighborhood Hits	124
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
NC score	0.157562 (rank : 152)	θ value	8.40245e-06 (rank : 115)
Query Neighborhood Hits	227	Target Neighborhood Hits	1029	Shared Neighborhood Hits	119
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

BLK_MOUSE
NC score	0.156560 (rank : 153)	θ value	9.92553e-07 (rank : 97)
Query Neighborhood Hits	227	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LCK_MOUSE
NC score	0.156497 (rank : 154)	θ value	4.45536e-07 (rank : 93)
Query Neighborhood Hits	227	Target Neighborhood Hits	981	Shared Neighborhood Hits	121
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

FRK_HUMAN
NC score	0.155886 (rank : 155)	θ value	3.77169e-06 (rank : 108)
Query Neighborhood Hits	227	Target Neighborhood Hits	1058	Shared Neighborhood Hits	134
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

BLK_HUMAN
NC score	0.152929 (rank : 156)	θ value	5.26297e-08 (rank : 80)
Query Neighborhood Hits	227	Target Neighborhood Hits	994	Shared Neighborhood Hits	116
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LYN_MOUSE
NC score	0.152583 (rank : 157)	θ value	1.43324e-05 (rank : 122)
Query Neighborhood Hits	227	Target Neighborhood Hits	1023	Shared Neighborhood Hits	123
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MATK_HUMAN
NC score	0.151736 (rank : 158)	θ value	1.80886e-08 (rank : 78)
Query Neighborhood Hits	227	Target Neighborhood Hits	954	Shared Neighborhood Hits	135
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

LYN_HUMAN
NC score	0.151689 (rank : 159)	θ value	4.1701e-05 (rank : 132)
Query Neighborhood Hits	227	Target Neighborhood Hits	1022	Shared Neighborhood Hits	123
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MATK_MOUSE
NC score	0.150481 (rank : 160)	θ value	1.38499e-08 (rank : 76)
Query Neighborhood Hits	227	Target Neighborhood Hits	952	Shared Neighborhood Hits	134
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SRMS_HUMAN
NC score	0.148330 (rank : 161)	θ value	1.87187e-05 (rank : 124)
Query Neighborhood Hits	227	Target Neighborhood Hits	946	Shared Neighborhood Hits	122
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

BTK_HUMAN
NC score	0.147983 (rank : 162)	θ value	3.77169e-06 (rank : 107)
Query Neighborhood Hits	227	Target Neighborhood Hits	1026	Shared Neighborhood Hits	116
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.147668 (rank : 163)	θ value	1.43324e-05 (rank : 120)
Query Neighborhood Hits	227	Target Neighborhood Hits	1017	Shared Neighborhood Hits	116
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SRMS_MOUSE
NC score	0.147453 (rank : 164)	θ value	1.87187e-05 (rank : 125)
Query Neighborhood Hits	227	Target Neighborhood Hits	964	Shared Neighborhood Hits	128
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

CC14B_MOUSE
NC score	0.147194 (rank : 165)	θ value	0.365318 (rank : 192)
Query Neighborhood Hits	227	Target Neighborhood Hits	103	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14B_HUMAN
NC score	0.146645 (rank : 166)	θ value	0.365318 (rank : 191)
Query Neighborhood Hits	227	Target Neighborhood Hits	114	Shared Neighborhood Hits	60
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

TXK_MOUSE
NC score	0.145398 (rank : 167)	θ value	0.00020696 (rank : 143)
Query Neighborhood Hits	227	Target Neighborhood Hits	980	Shared Neighborhood Hits	126
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

KSYK_MOUSE
NC score	0.144030 (rank : 168)	θ value	1.80886e-08 (rank : 77)
Query Neighborhood Hits	227	Target Neighborhood Hits	944	Shared Neighborhood Hits	127
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

PTK6_MOUSE
NC score	0.143999 (rank : 169)	θ value	0.000158464 (rank : 142)
Query Neighborhood Hits	227	Target Neighborhood Hits	1026	Shared Neighborhood Hits	127
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

KSYK_HUMAN
NC score	0.142437 (rank : 170)	θ value	3.41135e-07 (rank : 91)
Query Neighborhood Hits	227	Target Neighborhood Hits	901	Shared Neighborhood Hits	127
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TXK_HUMAN
NC score	0.141914 (rank : 171)	θ value	0.000270298 (rank : 146)
Query Neighborhood Hits	227	Target Neighborhood Hits	971	Shared Neighborhood Hits	121
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.141696 (rank : 172)	θ value	0.00102713 (rank : 158)
Query Neighborhood Hits	227	Target Neighborhood Hits	1020	Shared Neighborhood Hits	125
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

ITK_MOUSE
NC score	0.140479 (rank : 173)	θ value	3.19293e-05 (rank : 129)
Query Neighborhood Hits	227	Target Neighborhood Hits	985	Shared Neighborhood Hits	118
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

TEC_HUMAN
NC score	0.140142 (rank : 174)	θ value	7.1131e-05 (rank : 138)
Query Neighborhood Hits	227	Target Neighborhood Hits	1006	Shared Neighborhood Hits	112
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ITK_HUMAN
NC score	0.138898 (rank : 175)	θ value	0.000461057 (rank : 150)
Query Neighborhood Hits	227	Target Neighborhood Hits	1016	Shared Neighborhood Hits	121
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SOCS3_MOUSE
NC score	0.138673 (rank : 176)	θ value	0.0193708 (rank : 174)
Query Neighborhood Hits	227	Target Neighborhood Hits	72	Shared Neighborhood Hits	62
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

FER_HUMAN
NC score	0.137842 (rank : 177)	θ value	4.92598e-06 (rank : 110)
Query Neighborhood Hits	227	Target Neighborhood Hits	1278	Shared Neighborhood Hits	137
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SOCS3_HUMAN
NC score	0.137638 (rank : 178)	θ value	0.0193708 (rank : 173)
Query Neighborhood Hits	227	Target Neighborhood Hits	77	Shared Neighborhood Hits	61
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

BMX_HUMAN
NC score	0.137341 (rank : 179)	θ value	7.59969e-07 (rank : 96)
Query Neighborhood Hits	227	Target Neighborhood Hits	942	Shared Neighborhood Hits	115
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.137329 (rank : 180)	θ value	9.92553e-07 (rank : 98)
Query Neighborhood Hits	227	Target Neighborhood Hits	912	Shared Neighborhood Hits	114
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

TEC_MOUSE
NC score	0.136810 (rank : 181)	θ value	5.44631e-05 (rank : 137)
Query Neighborhood Hits	227	Target Neighborhood Hits	1006	Shared Neighborhood Hits	108
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SOCS2_MOUSE
NC score	0.136470 (rank : 182)	θ value	2.36792 (rank : 213)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

BLNK_MOUSE
NC score	0.134107 (rank : 183)	θ value	0.0113563 (rank : 169)
Query Neighborhood Hits	227	Target Neighborhood Hits	296	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CC14A_MOUSE
NC score	0.133043 (rank : 184)	θ value	1.06291 (rank : 200)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	58
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

BLNK_HUMAN
NC score	0.132248 (rank : 185)	θ value	0.0431538 (rank : 181)
Query Neighborhood Hits	227	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

SOCS7_MOUSE
NC score	0.131664 (rank : 186)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	227	Target Neighborhood Hits	154	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

CC14A_HUMAN
NC score	0.129994 (rank : 187)	θ value	1.06291 (rank : 199)
Query Neighborhood Hits	227	Target Neighborhood Hits	133	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

SOCS6_MOUSE
NC score	0.129619 (rank : 188)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	227	Target Neighborhood Hits	146	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

ZAP70_MOUSE
NC score	0.129592 (rank : 189)	θ value	0.000121331 (rank : 140)
Query Neighborhood Hits	227	Target Neighborhood Hits	905	Shared Neighborhood Hits	122
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FINC_HUMAN
NC score	0.128176 (rank : 190)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	227	Target Neighborhood Hits	302	Shared Neighborhood Hits	20
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

ZAP70_HUMAN
NC score	0.127927 (rank : 191)	θ value	0.00035302 (rank : 149)
Query Neighborhood Hits	227	Target Neighborhood Hits	893	Shared Neighborhood Hits	121
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SOCS6_HUMAN
NC score	0.127822 (rank : 192)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	89
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

FINC_MOUSE
NC score	0.127609 (rank : 193)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	227	Target Neighborhood Hits	309	Shared Neighborhood Hits	22
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

CHIN_MOUSE
NC score	0.126262 (rank : 194)	θ value	0.000602161 (rank : 151)
Query Neighborhood Hits	227	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SOCS2_HUMAN
NC score	0.125511 (rank : 195)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	227	Target Neighborhood Hits	104	Shared Neighborhood Hits	78
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

CHIN_HUMAN
NC score	0.122561 (rank : 196)	θ value	0.000786445 (rank : 154)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	99
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

TP4A1_HUMAN
NC score	0.122322 (rank : 197)	θ value	2.36792 (rank : 214)
Query Neighborhood Hits	227	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
NC score	0.122322 (rank : 198)	θ value	2.36792 (rank : 215)
Query Neighborhood Hits	227	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TENS4_MOUSE
NC score	0.121515 (rank : 199)	θ value	0.0252991 (rank : 176)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TENS4_HUMAN
NC score	0.119154 (rank : 200)	θ value	0.125558 (rank : 187)
Query Neighborhood Hits	227	Target Neighborhood Hits	214	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

FRMD1_HUMAN
NC score	0.117785 (rank : 201)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	227	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

FNDC3_HUMAN
NC score	0.116828 (rank : 202)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	227	Target Neighborhood Hits	196	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

EPHB6_HUMAN
NC score	0.113525 (rank : 203)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	227	Target Neighborhood Hits	912	Shared Neighborhood Hits	65
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

SOCS1_MOUSE
NC score	0.113469 (rank : 204)	θ value	0.813845 (rank : 196)
Query Neighborhood Hits	227	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

NPHP1_MOUSE
NC score	0.113069 (rank : 205)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	227	Target Neighborhood Hits	267	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

FRMD6_MOUSE
NC score	0.112877 (rank : 206)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	227	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

TIE1_MOUSE
NC score	0.112592 (rank : 207)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	227	Target Neighborhood Hits	1266	Shared Neighborhood Hits	65
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHB6_MOUSE
NC score	0.112501 (rank : 208)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	227	Target Neighborhood Hits	906	Shared Neighborhood Hits	63
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

FES_HUMAN
NC score	0.111394 (rank : 209)	θ value	0.0252991 (rank : 175)
Query Neighborhood Hits	227	Target Neighborhood Hits	978	Shared Neighborhood Hits	100
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

E41LA_MOUSE
NC score	0.109961 (rank : 210)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

CHIO_HUMAN
NC score	0.109650 (rank : 211)	θ value	0.00102713 (rank : 156)
Query Neighborhood Hits	227	Target Neighborhood Hits	220	Shared Neighborhood Hits	93
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

E41LA_HUMAN
NC score	0.109511 (rank : 212)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	227	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

FRMD6_HUMAN
NC score	0.109288 (rank : 213)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	8
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

TIE2_MOUSE
NC score	0.109081 (rank : 214)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	227	Target Neighborhood Hits	1204	Shared Neighborhood Hits	62
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

FNDC3_MOUSE
NC score	0.108964 (rank : 215)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	227	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

CISH_MOUSE
NC score	0.108668 (rank : 216)	θ value	4.03905 (rank : 219)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SOCS1_HUMAN
NC score	0.108513 (rank : 217)	θ value	0.813845 (rank : 195)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	57
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

ROS_HUMAN
NC score	0.108158 (rank : 218)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	227	Target Neighborhood Hits	907	Shared Neighborhood Hits	63
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

TIE1_HUMAN
NC score	0.108121 (rank : 219)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	227	Target Neighborhood Hits	1241	Shared Neighborhood Hits	65
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

CISH_HUMAN
NC score	0.107256 (rank : 220)	θ value	4.03905 (rank : 218)
Query Neighborhood Hits	227	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

TIE2_HUMAN
NC score	0.106691 (rank : 221)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	227	Target Neighborhood Hits	1192	Shared Neighborhood Hits	63
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

UFO_HUMAN
NC score	0.106469 (rank : 222)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	227	Target Neighborhood Hits	981	Shared Neighborhood Hits	61
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

TP4A2_HUMAN
NC score	0.106293 (rank : 223)	θ value	1.81305 (rank : 210)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	36
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
NC score	0.106293 (rank : 224)	θ value	1.81305 (rank : 211)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	36
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

E41LB_MOUSE
NC score	0.106068 (rank : 225)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	227	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

MERTK_HUMAN
NC score	0.106018 (rank : 226)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	227	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

EPHA7_MOUSE
NC score	0.106002 (rank : 227)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	227	Target Neighborhood Hits	1025	Shared Neighborhood Hits	66
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA7_HUMAN
NC score	0.105597 (rank : 228)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	227	Target Neighborhood Hits	1053	Shared Neighborhood Hits	65
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

FES_MOUSE
NC score	0.105530 (rank : 229)	θ value	0.0736092 (rank : 182)
Query Neighborhood Hits	227	Target Neighborhood Hits	980	Shared Neighborhood Hits	91
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

EPHA3_MOUSE
NC score	0.105516 (rank : 230)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	63
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA8_MOUSE
NC score	0.105316 (rank : 231)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	227	Target Neighborhood Hits	969	Shared Neighborhood Hits	65
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA8_HUMAN
NC score	0.105182 (rank : 232)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	227	Target Neighborhood Hits	956	Shared Neighborhood Hits	65
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

IGF1R_HUMAN
NC score	0.105107 (rank : 233)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	227	Target Neighborhood Hits	977	Shared Neighborhood Hits	61
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
NC score	0.104988 (rank : 234)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	227	Target Neighborhood Hits	973	Shared Neighborhood Hits	61
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

E41L5_HUMAN
NC score	0.104445 (rank : 235)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	227	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

EPHA4_MOUSE
NC score	0.104371 (rank : 236)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	227	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.103986 (rank : 237)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	227	Target Neighborhood Hits	975	Shared Neighborhood Hits	63
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA5_MOUSE
NC score	0.103874 (rank : 238)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	227	Target Neighborhood Hits	950	Shared Neighborhood Hits	65
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

MERTK_MOUSE
NC score	0.103708 (rank : 239)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	227	Target Neighborhood Hits	974	Shared Neighborhood Hits	55
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

E41LB_HUMAN
NC score	0.103693 (rank : 240)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

EPHA3_HUMAN
NC score	0.103444 (rank : 241)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	227	Target Neighborhood Hits	1005	Shared Neighborhood Hits	63
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

NPHP1_HUMAN
NC score	0.103322 (rank : 242)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

TP4A3_HUMAN
NC score	0.103187 (rank : 243)	θ value	4.03905 (rank : 222)
Query Neighborhood Hits	227	Target Neighborhood Hits	62	Shared Neighborhood Hits	35
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

EPHA6_HUMAN
NC score	0.103050 (rank : 244)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	227	Target Neighborhood Hits	959	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

TYRO3_MOUSE
NC score	0.102882 (rank : 245)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	227	Target Neighborhood Hits	1007	Shared Neighborhood Hits	56
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

EPHA5_HUMAN
NC score	0.102610 (rank : 246)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	227	Target Neighborhood Hits	1009	Shared Neighborhood Hits	65
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

FRMD5_MOUSE
NC score	0.102460 (rank : 247)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	227	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L3_HUMAN
NC score	0.102459 (rank : 248)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	227	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

41_HUMAN
NC score	0.102439 (rank : 249)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

UFO_MOUSE
NC score	0.102041 (rank : 250)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	227	Target Neighborhood Hits	988	Shared Neighborhood Hits	57
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

41_MOUSE
NC score	0.101896 (rank : 251)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	227	Target Neighborhood Hits	184	Shared Neighborhood Hits	13
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

FRMD5_HUMAN
NC score	0.101532 (rank : 252)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	227	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

INSRR_HUMAN
NC score	0.101320 (rank : 253)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	227	Target Neighborhood Hits	950	Shared Neighborhood Hits	62
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

E41L2_HUMAN
NC score	0.101098 (rank : 254)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	227	Target Neighborhood Hits	287	Shared Neighborhood Hits	12
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

TYRO3_HUMAN
NC score	0.101084 (rank : 255)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	227	Target Neighborhood Hits	995	Shared Neighborhood Hits	54
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHA6_MOUSE
NC score	0.100889 (rank : 256)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	227	Target Neighborhood Hits	946	Shared Neighborhood Hits	62
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

E41L1_MOUSE
NC score	0.100465 (rank : 257)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	227	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

MYLIP_MOUSE
NC score	0.100066 (rank : 258)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

E41L1_HUMAN
NC score	0.099909 (rank : 259)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	227	Target Neighborhood Hits	180	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

EPHB2_MOUSE
NC score	0.099175 (rank : 260)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	227	Target Neighborhood Hits	982	Shared Neighborhood Hits	62
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

E41L3_MOUSE
NC score	0.099163 (rank : 261)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	227	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

EPHB2_HUMAN
NC score	0.099141 (rank : 262)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	227	Target Neighborhood Hits	983	Shared Neighborhood Hits	62
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

INSR_MOUSE
NC score	0.099122 (rank : 263)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	227	Target Neighborhood Hits	968	Shared Neighborhood Hits	60
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_HUMAN
NC score	0.098838 (rank : 264)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	227	Target Neighborhood Hits	963	Shared Neighborhood Hits	60
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHB3_MOUSE
NC score	0.098619 (rank : 265)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	227	Target Neighborhood Hits	996	Shared Neighborhood Hits	63
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_MOUSE
NC score	0.097847 (rank : 266)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	227	Target Neighborhood Hits	1013	Shared Neighborhood Hits	64
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB3_HUMAN
NC score	0.097407 (rank : 267)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	227	Target Neighborhood Hits	996	Shared Neighborhood Hits	62
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

MUSK_HUMAN
NC score	0.097173 (rank : 268)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	227	Target Neighborhood Hits	1074	Shared Neighborhood Hits	55
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

INSRR_MOUSE
NC score	0.097013 (rank : 269)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	227	Target Neighborhood Hits	961	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

EPHB1_HUMAN
NC score	0.096953 (rank : 270)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	227	Target Neighborhood Hits	988	Shared Neighborhood Hits	61
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB4_HUMAN
NC score	0.096833 (rank : 271)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	227	Target Neighborhood Hits	1056	Shared Neighborhood Hits	64
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

MUSK_MOUSE
NC score	0.096719 (rank : 272)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	227	Target Neighborhood Hits	1057	Shared Neighborhood Hits	55
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

EPHAA_HUMAN
NC score	0.096453 (rank : 273)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	227	Target Neighborhood Hits	960	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

STAC3_MOUSE
NC score	0.096213 (rank : 274)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	227	Target Neighborhood Hits	232	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DCC_HUMAN
NC score	0.096167 (rank : 275)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	227	Target Neighborhood Hits	583	Shared Neighborhood Hits	21
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

E41L2_MOUSE
NC score	0.095847 (rank : 276)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	227	Target Neighborhood Hits	459	Shared Neighborhood Hits	8
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

STAC3_HUMAN
NC score	0.095754 (rank : 277)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	227	Target Neighborhood Hits	228	Shared Neighborhood Hits	54
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TP4A3_MOUSE
NC score	0.095513 (rank : 278)	θ value	1.38821 (rank : 205)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

MYLIP_HUMAN
NC score	0.095192 (rank : 279)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

EPHA2_HUMAN
NC score	0.094647 (rank : 280)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	227	Target Neighborhood Hits	1021	Shared Neighborhood Hits	61
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

NEO1_MOUSE
NC score	0.094255 (rank : 281)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	227	Target Neighborhood Hits	523	Shared Neighborhood Hits	21
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

ACK1_MOUSE
NC score	0.093558 (rank : 282)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	227	Target Neighborhood Hits	1080	Shared Neighborhood Hits	60
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

RYK_HUMAN
NC score	0.093549 (rank : 283)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	227	Target Neighborhood Hits	701	Shared Neighborhood Hits	47
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

ROR2_MOUSE
NC score	0.093361 (rank : 284)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	227	Target Neighborhood Hits	1000	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

PGFRA_MOUSE
NC score	0.092780 (rank : 285)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	227	Target Neighborhood Hits	975	Shared Neighborhood Hits	53
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

DCC_MOUSE
NC score	0.092722 (rank : 286)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	227	Target Neighborhood Hits	896	Shared Neighborhood Hits	24
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

RYK_MOUSE
NC score	0.092717 (rank : 287)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	47
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

STYK1_HUMAN
NC score	0.092683 (rank : 288)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	227	Target Neighborhood Hits	786	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

ACK1_HUMAN
NC score	0.092362 (rank : 289)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	227	Target Neighborhood Hits	1140	Shared Neighborhood Hits	59
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

PGFRA_HUMAN
NC score	0.092288 (rank : 290)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	227	Target Neighborhood Hits	980	Shared Neighborhood Hits	53
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PTEN_HUMAN
NC score	0.092220 (rank : 291)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	227	Target Neighborhood Hits	72	Shared Neighborhood Hits	40
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
NC score	0.092220 (rank : 292)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	227	Target Neighborhood Hits	73	Shared Neighborhood Hits	40
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

FRM4B_MOUSE
NC score	0.092104 (rank : 293)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	227	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

EPHA2_MOUSE
NC score	0.091799 (rank : 294)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	227	Target Neighborhood Hits	1020	Shared Neighborhood Hits	59
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

STYK1_MOUSE
NC score	0.091782 (rank : 295)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	227	Target Neighborhood Hits	779	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

FGFR4_MOUSE
NC score	0.091652 (rank : 296)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	227	Target Neighborhood Hits	1026	Shared Neighborhood Hits	53
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

LTK_HUMAN
NC score	0.091535 (rank : 297)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	227	Target Neighborhood Hits	774	Shared Neighborhood Hits	49
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

NEO1_HUMAN
NC score	0.091372 (rank : 298)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	227	Target Neighborhood Hits	530	Shared Neighborhood Hits	21
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

ALK_MOUSE
NC score	0.091194 (rank : 299)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	227	Target Neighborhood Hits	811	Shared Neighborhood Hits	52
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

MAMC2_MOUSE
NC score	0.091015 (rank : 300)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	227	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

FRM4B_HUMAN
NC score	0.090670 (rank : 301)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

LTK_MOUSE
NC score	0.090621 (rank : 302)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	227	Target Neighborhood Hits	770	Shared Neighborhood Hits	49
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

STAC_MOUSE
NC score	0.090449 (rank : 303)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	227	Target Neighborhood Hits	268	Shared Neighborhood Hits	53
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ROR2_HUMAN
NC score	0.090390 (rank : 304)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	227	Target Neighborhood Hits	1014	Shared Neighborhood Hits	55
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

FRM4A_HUMAN
NC score	0.090304 (rank : 305)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	227	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

EPHA1_HUMAN
NC score	0.090100 (rank : 306)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	227	Target Neighborhood Hits	997	Shared Neighborhood Hits	54
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
NC score	0.090099 (rank : 307)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	227	Target Neighborhood Hits	958	Shared Neighborhood Hits	56
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

ALK_HUMAN
NC score	0.090089 (rank : 308)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	227	Target Neighborhood Hits	795	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

CSF1R_HUMAN
NC score	0.090060 (rank : 309)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	227	Target Neighborhood Hits	943	Shared Neighborhood Hits	53
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

MERL_MOUSE
NC score	0.089752 (rank : 310)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	227	Target Neighborhood Hits	524	Shared Neighborhood Hits	15
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MERL_HUMAN
NC score	0.089475 (rank : 311)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	227	Target Neighborhood Hits	532	Shared Neighborhood Hits	15
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

ROR1_MOUSE
NC score	0.089408 (rank : 312)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	227	Target Neighborhood Hits	1025	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

FGFR4_HUMAN
NC score	0.089225 (rank : 313)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	227	Target Neighborhood Hits	1037	Shared Neighborhood Hits	53
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FARP2_MOUSE
NC score	0.089200 (rank : 314)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	227	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PTK7_HUMAN
NC score	0.089046 (rank : 315)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	227	Target Neighborhood Hits	1103	Shared Neighborhood Hits	54
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

CD2AP_HUMAN
NC score	0.088690 (rank : 316)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	227	Target Neighborhood Hits	315	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ROR1_HUMAN
NC score	0.088575 (rank : 317)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	227	Target Neighborhood Hits	1018	Shared Neighborhood Hits	53
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

FRM4A_MOUSE
NC score	0.088573 (rank : 318)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	227	Target Neighborhood Hits	108	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

TENN_MOUSE
NC score	0.088105 (rank : 319)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	227	Target Neighborhood Hits	484	Shared Neighborhood Hits	19
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

CD2AP_MOUSE
NC score	0.087671 (rank : 320)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	227	Target Neighborhood Hits	336	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CSF1R_MOUSE
NC score	0.087435 (rank : 321)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	227	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FAK2_HUMAN
NC score	0.087364 (rank : 322)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	227	Target Neighborhood Hits	847	Shared Neighborhood Hits	49
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

MAMC2_HUMAN
NC score	0.087259 (rank : 323)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	227	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

DDR1_MOUSE
NC score	0.087161 (rank : 324)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	227	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

KIT_MOUSE
NC score	0.087139 (rank : 325)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	227	Target Neighborhood Hits	949	Shared Neighborhood Hits	53
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

DDR1_HUMAN
NC score	0.086872 (rank : 326)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	227	Target Neighborhood Hits	819	Shared Neighborhood Hits	52
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

FAK2_MOUSE
NC score	0.086783 (rank : 327)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	227	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

STAM2_MOUSE
NC score	0.086760 (rank : 328)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	227	Target Neighborhood Hits	285	Shared Neighborhood Hits	50
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VGFR2_HUMAN
NC score	0.086693 (rank : 329)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	227	Target Neighborhood Hits	1103	Shared Neighborhood Hits	53
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

NTRK3_HUMAN
NC score	0.086621 (rank : 330)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	227	Target Neighborhood Hits	1115	Shared Neighborhood Hits	53
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

TNK1_HUMAN
NC score	0.086567 (rank : 331)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	227	Target Neighborhood Hits	815	Shared Neighborhood Hits	53
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

AATK_MOUSE
NC score	0.086357 (rank : 332)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	227	Target Neighborhood Hits	942	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

FGFR2_HUMAN
NC score	0.086309 (rank : 333)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	227	Target Neighborhood Hits	1062	Shared Neighborhood Hits	53
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FARP1_HUMAN
NC score	0.086123 (rank : 334)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	227	Target Neighborhood Hits	241	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TNK1_MOUSE
NC score	0.086009 (rank : 335)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	227	Target Neighborhood Hits	806	Shared Neighborhood Hits	56
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

STAM2_HUMAN
NC score	0.085962 (rank : 336)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

KIT_HUMAN
NC score	0.085948 (rank : 337)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	227	Target Neighborhood Hits	953	Shared Neighborhood Hits	53
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

FGFR3_HUMAN
NC score	0.085899 (rank : 338)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	227	Target Neighborhood Hits	1042	Shared Neighborhood Hits	53
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

ERBB3_HUMAN
NC score	0.085865 (rank : 339)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	227	Target Neighborhood Hits	918	Shared Neighborhood Hits	49
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

FGFR3_MOUSE
NC score	0.085791 (rank : 340)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	227	Target Neighborhood Hits	1059	Shared Neighborhood Hits	53
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FLT3_MOUSE
NC score	0.085620 (rank : 341)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	227	Target Neighborhood Hits	847	Shared Neighborhood Hits	49
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

JAK1_MOUSE
NC score	0.085616 (rank : 342)	θ value	0.0330416 (rank : 177)
Query Neighborhood Hits	227	Target Neighborhood Hits	854	Shared Neighborhood Hits	56
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

ERBB3_MOUSE
NC score	0.085573 (rank : 343)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	227	Target Neighborhood Hits	898	Shared Neighborhood Hits	49
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

STAC_HUMAN
NC score	0.085565 (rank : 344)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	227	Target Neighborhood Hits	276	Shared Neighborhood Hits	55
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

COCA1_MOUSE
NC score	0.085519 (rank : 345)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	227	Target Neighborhood Hits	467	Shared Neighborhood Hits	20
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

FGFR2_MOUSE
NC score	0.085490 (rank : 346)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	227	Target Neighborhood Hits	1062	Shared Neighborhood Hits	53
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

ERBB2_HUMAN
NC score	0.085375 (rank : 347)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	227	Target Neighborhood Hits	1073	Shared Neighborhood Hits	52
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB4_HUMAN
NC score	0.085364 (rank : 348)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	227	Target Neighborhood Hits	910	Shared Neighborhood Hits	51
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

VINEX_MOUSE
NC score	0.085351 (rank : 349)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	227	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

FLT3_HUMAN
NC score	0.085280 (rank : 350)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	227	Target Neighborhood Hits	843	Shared Neighborhood Hits	49
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FGFR1_HUMAN
NC score	0.085218 (rank : 351)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	227	Target Neighborhood Hits	1069	Shared Neighborhood Hits	53
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

VGFR2_MOUSE
NC score	0.085169 (rank : 352)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	227	Target Neighborhood Hits	1089	Shared Neighborhood Hits	54
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

FGFR1_MOUSE
NC score	0.085148 (rank : 353)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	227	Target Neighborhood Hits	1068	Shared Neighborhood Hits	53
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

NTRK2_HUMAN
NC score	0.084996 (rank : 354)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	227	Target Neighborhood Hits	1081	Shared Neighborhood Hits	53
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

ERBB2_MOUSE
NC score	0.084992 (rank : 355)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	227	Target Neighborhood Hits	918	Shared Neighborhood Hits	49
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

NTRK2_MOUSE
NC score	0.084912 (rank : 356)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	227	Target Neighborhood Hits	1088	Shared Neighborhood Hits	53
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK1_HUMAN
NC score	0.084754 (rank : 357)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	227	Target Neighborhood Hits	1023	Shared Neighborhood Hits	50
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

PGFRB_HUMAN
NC score	0.084580 (rank : 358)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	227	Target Neighborhood Hits	962	Shared Neighborhood Hits	52
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

VINEX_HUMAN
NC score	0.084543 (rank : 359)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	227	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PGFRB_MOUSE
NC score	0.084465 (rank : 360)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	227	Target Neighborhood Hits	960	Shared Neighborhood Hits	53
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

STAM1_HUMAN
NC score	0.084368 (rank : 361)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	227	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SRBS1_MOUSE
NC score	0.084326 (rank : 362)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	227	Target Neighborhood Hits	409	Shared Neighborhood Hits	56
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM1_MOUSE
NC score	0.084285 (rank : 363)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	227	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

AATK_HUMAN
NC score	0.084197 (rank : 364)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	227	Target Neighborhood Hits	1243	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

RON_MOUSE
NC score	0.084118 (rank : 365)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	227	Target Neighborhood Hits	836	Shared Neighborhood Hits	49
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FARP2_HUMAN
NC score	0.084108 (rank : 366)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	227	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SRBS1_HUMAN
NC score	0.084070 (rank : 367)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

FAK1_MOUSE
NC score	0.083639 (rank : 368)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	227	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.083600 (rank : 369)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	227	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

COCA1_HUMAN
NC score	0.083183 (rank : 370)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	227	Target Neighborhood Hits	458	Shared Neighborhood Hits	22
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

EGFR_MOUSE
NC score	0.083153 (rank : 371)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	227	Target Neighborhood Hits	927	Shared Neighborhood Hits	50
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

JAK1_HUMAN
NC score	0.082988 (rank : 372)	θ value	0.163984 (rank : 188)
Query Neighborhood Hits	227	Target Neighborhood Hits	858	Shared Neighborhood Hits	55
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

DDR2_HUMAN
NC score	0.082762 (rank : 373)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	227	Target Neighborhood Hits	818	Shared Neighborhood Hits	49
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

RON_HUMAN
NC score	0.082697 (rank : 374)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	227	Target Neighborhood Hits	842	Shared Neighborhood Hits	49
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

EGFR_HUMAN
NC score	0.082672 (rank : 375)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	227	Target Neighborhood Hits	939	Shared Neighborhood Hits	49
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

DDR2_MOUSE
NC score	0.082618 (rank : 376)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	227	Target Neighborhood Hits	813	Shared Neighborhood Hits	49
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

RET_HUMAN
NC score	0.082287 (rank : 377)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	227	Target Neighborhood Hits	873	Shared Neighborhood Hits	49
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

VGFR1_MOUSE
NC score	0.082015 (rank : 378)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	227	Target Neighborhood Hits	1118	Shared Neighborhood Hits	54
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

RET_MOUSE
NC score	0.081600 (rank : 379)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	227	Target Neighborhood Hits	884	Shared Neighborhood Hits	49
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

MET_MOUSE
NC score	0.081541 (rank : 380)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	227	Target Neighborhood Hits	844	Shared Neighborhood Hits	49
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

SDK2_MOUSE
NC score	0.081475 (rank : 381)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	227	Target Neighborhood Hits	480	Shared Neighborhood Hits	18
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

VGFR3_HUMAN
NC score	0.081282 (rank : 382)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	227	Target Neighborhood Hits	1037	Shared Neighborhood Hits	53
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

MET_HUMAN
NC score	0.081211 (rank : 383)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	227	Target Neighborhood Hits	831	Shared Neighborhood Hits	49
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

PPIP1_HUMAN
NC score	0.081181 (rank : 384)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	227	Target Neighborhood Hits	389	Shared Neighborhood Hits	63
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

NCF2_HUMAN
NC score	0.080760 (rank : 385)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	227	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VGFR1_HUMAN
NC score	0.080572 (rank : 386)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	227	Target Neighborhood Hits	1109	Shared Neighborhood Hits	53
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR3_MOUSE
NC score	0.080456 (rank : 387)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	227	Target Neighborhood Hits	1056	Shared Neighborhood Hits	53
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

DNMBP_HUMAN
NC score	0.080319 (rank : 388)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	227	Target Neighborhood Hits	413	Shared Neighborhood Hits	58
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ES8L3_HUMAN
NC score	0.079955 (rank : 389)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	227	Target Neighborhood Hits	206	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

RADI_HUMAN
NC score	0.079742 (rank : 390)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	227	Target Neighborhood Hits	741	Shared Neighborhood Hits	23
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

USH2A_HUMAN
NC score	0.079557 (rank : 391)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	227	Target Neighborhood Hits	600	Shared Neighborhood Hits	21
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

M3KL4_HUMAN
NC score	0.079503 (rank : 392)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	227	Target Neighborhood Hits	1087	Shared Neighborhood Hits	73
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SH3K1_MOUSE
NC score	0.079317 (rank : 393)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	227	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SDK1_MOUSE
NC score	0.079001 (rank : 394)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	227	Target Neighborhood Hits	495	Shared Neighborhood Hits	22
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

OSTF1_HUMAN
NC score	0.078811 (rank : 395)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	227	Target Neighborhood Hits	466	Shared Neighborhood Hits	50
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3K1_HUMAN
NC score	0.078556 (rank : 396)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	227	Target Neighborhood Hits	341	Shared Neighborhood Hits	49
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SDK2_HUMAN
NC score	0.078491 (rank : 397)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	227	Target Neighborhood Hits	495	Shared Neighborhood Hits	19
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

ARHG7_MOUSE
NC score	0.078404 (rank : 398)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

M3K11_HUMAN
NC score	0.078397 (rank : 399)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	227	Target Neighborhood Hits	1136	Shared Neighborhood Hits	71
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SPN90_HUMAN
NC score	0.078342 (rank : 400)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

RADI_MOUSE
NC score	0.078328 (rank : 401)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	227	Target Neighborhood Hits	773	Shared Neighborhood Hits	21
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

PPIP1_MOUSE
NC score	0.078273 (rank : 402)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	227	Target Neighborhood Hits	377	Shared Neighborhood Hits	60
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

EZRI_HUMAN
NC score	0.077977 (rank : 403)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	227	Target Neighborhood Hits	663	Shared Neighborhood Hits	22
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

NCF1_HUMAN
NC score	0.077859 (rank : 404)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
NC score	0.077729 (rank : 405)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

HCLS1_HUMAN
NC score	0.077599 (rank : 406)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	227	Target Neighborhood Hits	358	Shared Neighborhood Hits	50
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SDK1_HUMAN
NC score	0.077511 (rank : 407)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	227	Target Neighborhood Hits	511	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

HCLS1_MOUSE
NC score	0.077419 (rank : 408)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	227	Target Neighborhood Hits	329	Shared Neighborhood Hits	54
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ARHG6_HUMAN
NC score	0.077355 (rank : 409)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	227	Target Neighborhood Hits	376	Shared Neighborhood Hits	49
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_HUMAN
NC score	0.077185 (rank : 410)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	227	Target Neighborhood Hits	347	Shared Neighborhood Hits	48
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

EZRI_MOUSE
NC score	0.077156 (rank : 411)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	227	Target Neighborhood Hits	693	Shared Neighborhood Hits	22
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

SRC8_HUMAN
NC score	0.076990 (rank : 412)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	227	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

MLKL_HUMAN
NC score	0.076797 (rank : 413)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	227	Target Neighborhood Hits	600	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

USH2A_MOUSE
NC score	0.076747 (rank : 414)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	227	Target Neighborhood Hits	626	Shared Neighborhood Hits	20
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

TYK2_MOUSE
NC score	0.076303 (rank : 415)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	227	Target Neighborhood Hits	850	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

M3K9_HUMAN
NC score	0.076018 (rank : 416)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	227	Target Neighborhood Hits	1123	Shared Neighborhood Hits	72
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

TENS1_HUMAN
NC score	0.075936 (rank : 417)	θ value	0.21417 (rank : 190)
Query Neighborhood Hits	227	Target Neighborhood Hits	400	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

PACN2_HUMAN
NC score	0.075827 (rank : 418)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	227	Target Neighborhood Hits	339	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

M3K10_HUMAN
NC score	0.075626 (rank : 419)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	227	Target Neighborhood Hits	1071	Shared Neighborhood Hits	71
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

JAK3_HUMAN
NC score	0.075415 (rank : 420)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	227	Target Neighborhood Hits	827	Shared Neighborhood Hits	49
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

TEX14_HUMAN
NC score	0.075380 (rank : 421)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	227	Target Neighborhood Hits	1103	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

GUC2F_HUMAN
NC score	0.075253 (rank : 422)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	227	Target Neighborhood Hits	740	Shared Neighborhood Hits	49
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

DNMBP_MOUSE
NC score	0.075234 (rank : 423)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	227	Target Neighborhood Hits	435	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

AHI1_HUMAN
NC score	0.075160 (rank : 424)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	227	Target Neighborhood Hits	537	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SRC8_MOUSE
NC score	0.075114 (rank : 425)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	227	Target Neighborhood Hits	292	Shared Neighborhood Hits	53
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

TYK2_HUMAN
NC score	0.074877 (rank : 426)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	227	Target Neighborhood Hits	841	Shared Neighborhood Hits	49
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

ABI2_HUMAN
NC score	0.074798 (rank : 427)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	227	Target Neighborhood Hits	350	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

MLKL_MOUSE
NC score	0.074750 (rank : 428)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	227	Target Neighborhood Hits	707	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ITB4_HUMAN
NC score	0.074626 (rank : 429)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	227	Target Neighborhood Hits	458	Shared Neighborhood Hits	16
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

TENN_HUMAN
NC score	0.074516 (rank : 430)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	227	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

CDKN3_HUMAN
NC score	0.074491 (rank : 431)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	227	Target Neighborhood Hits	27	Shared Neighborhood Hits	19
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

GUC2C_HUMAN
NC score	0.074075 (rank : 432)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	227	Target Neighborhood Hits	624	Shared Neighborhood Hits	49
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

PACN2_MOUSE
NC score	0.074074 (rank : 433)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	227	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

OSTF1_MOUSE
NC score	0.074035 (rank : 434)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	227	Target Neighborhood Hits	467	Shared Neighborhood Hits	50
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

TENR_HUMAN
NC score	0.073634 (rank : 435)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	227	Target Neighborhood Hits	526	Shared Neighborhood Hits	17
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

ABI2_MOUSE
NC score	0.073474 (rank : 436)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	227	Target Neighborhood Hits	266	Shared Neighborhood Hits	48
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

JAK2_MOUSE
NC score	0.073443 (rank : 437)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	227	Target Neighborhood Hits	839	Shared Neighborhood Hits	52
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

TENR_MOUSE
NC score	0.073358 (rank : 438)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	227	Target Neighborhood Hits	531	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

TEX14_MOUSE
NC score	0.073075 (rank : 439)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	227	Target Neighborhood Hits	1333	Shared Neighborhood Hits	54
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

PACN1_MOUSE
NC score	0.073050 (rank : 440)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	227	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.072963 (rank : 441)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	227	Target Neighborhood Hits	320	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ANPRA_MOUSE
NC score	0.072934 (rank : 442)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	227	Target Neighborhood Hits	600	Shared Neighborhood Hits	49
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.072926 (rank : 443)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	227	Target Neighborhood Hits	612	Shared Neighborhood Hits	49
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

JAK2_HUMAN
NC score	0.072828 (rank : 444)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	227	Target Neighborhood Hits	847	Shared Neighborhood Hits	51
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_MOUSE
NC score	0.072810 (rank : 445)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	227	Target Neighborhood Hits	821	Shared Neighborhood Hits	49
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

L1CAM_MOUSE
NC score	0.072447 (rank : 446)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	227	Target Neighborhood Hits	457	Shared Neighborhood Hits	21
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

AHI1_MOUSE
NC score	0.072419 (rank : 447)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	227	Target Neighborhood Hits	496	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG6_MOUSE
NC score	0.072261 (rank : 448)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	227	Target Neighborhood Hits	394	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ES8L3_MOUSE
NC score	0.072075 (rank : 449)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	227	Target Neighborhood Hits	168	Shared Neighborhood Hits	50
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

MOES_HUMAN
NC score	0.071786 (rank : 450)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	227	Target Neighborhood Hits	892	Shared Neighborhood Hits	21
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

L1CAM_HUMAN
NC score	0.071546 (rank : 451)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	227	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

ILK_MOUSE
NC score	0.071487 (rank : 452)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	227	Target Neighborhood Hits	858	Shared Neighborhood Hits	49
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

NRCAM_MOUSE
NC score	0.071132 (rank : 453)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	227	Target Neighborhood Hits	432	Shared Neighborhood Hits	15
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

SPN90_MOUSE
NC score	0.071012 (rank : 454)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

MOES_MOUSE
NC score	0.070794 (rank : 455)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	227	Target Neighborhood Hits	923	Shared Neighborhood Hits	23
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

ILK1_HUMAN
NC score	0.070772 (rank : 456)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	227	Target Neighborhood Hits	857	Shared Neighborhood Hits	49
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

DSCAM_HUMAN
NC score	0.070614 (rank : 457)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	227	Target Neighborhood Hits	524	Shared Neighborhood Hits	17
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
NC score	0.070546 (rank : 458)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	227	Target Neighborhood Hits	589	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

PACN3_MOUSE
NC score	0.070330 (rank : 459)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	227	Target Neighborhood Hits	380	Shared Neighborhood Hits	58
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

RIMB2_MOUSE
NC score	0.070295 (rank : 460)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	227	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ILK2_HUMAN
NC score	0.070001 (rank : 461)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	227	Target Neighborhood Hits	848	Shared Neighborhood Hits	49
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

PACN3_HUMAN
NC score	0.069549 (rank : 462)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	227	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ARAF_HUMAN
NC score	0.069357 (rank : 463)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	227	Target Neighborhood Hits	924	Shared Neighborhood Hits	58
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

MDGA1_HUMAN
NC score	0.069245 (rank : 464)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	227	Target Neighborhood Hits	358	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

CNTN5_HUMAN
NC score	0.069206 (rank : 465)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	227	Target Neighborhood Hits	446	Shared Neighborhood Hits	15
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

BRAF1_HUMAN
NC score	0.069169 (rank : 466)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	227	Target Neighborhood Hits	883	Shared Neighborhood Hits	59
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

ARAF_MOUSE
NC score	0.069118 (rank : 467)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	56
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

COEA1_MOUSE
NC score	0.069096 (rank : 468)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	227	Target Neighborhood Hits	402	Shared Neighborhood Hits	15
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

ANPRB_MOUSE
NC score	0.069058 (rank : 469)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	227	Target Neighborhood Hits	607	Shared Neighborhood Hits	53
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

NRCAM_HUMAN
NC score	0.069016 (rank : 470)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	227	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

RAF1_HUMAN
NC score	0.068896 (rank : 471)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	227	Target Neighborhood Hits	886	Shared Neighborhood Hits	57
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ANPRB_HUMAN
NC score	0.068537 (rank : 472)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	227	Target Neighborhood Hits	646	Shared Neighborhood Hits	53
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

RAF1_MOUSE
NC score	0.068455 (rank : 473)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	227	Target Neighborhood Hits	886	Shared Neighborhood Hits	57
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RIMB2_HUMAN
NC score	0.068177 (rank : 474)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	227	Target Neighborhood Hits	263	Shared Neighborhood Hits	31
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CNTN5_MOUSE
NC score	0.067610 (rank : 475)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	227	Target Neighborhood Hits	434	Shared Neighborhood Hits	14
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

ES8L2_MOUSE
NC score	0.067356 (rank : 476)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	54
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MLTK_HUMAN
NC score	0.067291 (rank : 477)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	227	Target Neighborhood Hits	911	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
NC score	0.067232 (rank : 478)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

RIPK1_MOUSE
NC score	0.067035 (rank : 479)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	49
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

CNTN2_HUMAN
NC score	0.067000 (rank : 480)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	227	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
NC score	0.066858 (rank : 481)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	227	Target Neighborhood Hits	450	Shared Neighborhood Hits	12
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

ITSN2_HUMAN
NC score	0.066670 (rank : 482)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	227	Target Neighborhood Hits	1173	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

GUC2E_MOUSE
NC score	0.066651 (rank : 483)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	227	Target Neighborhood Hits	692	Shared Neighborhood Hits	48
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

MOS_HUMAN
NC score	0.066516 (rank : 484)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	227	Target Neighborhood Hits	829	Shared Neighborhood Hits	49
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

IRAK3_MOUSE
NC score	0.066131 (rank : 485)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	227	Target Neighborhood Hits	628	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MAMC1_MOUSE
NC score	0.066097 (rank : 486)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	227	Target Neighborhood Hits	357	Shared Neighborhood Hits	11
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

ES8L2_HUMAN
NC score	0.065921 (rank : 487)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	227	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

RES18_MOUSE
NC score	0.065914 (rank : 488)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	227	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P47939	Gene names	Resp18
Domain Architecture	No domain graphic available
Description	Regulated endocrine-specific protein 18 precursor [Contains: Regulated endocrine-specific protein 18; Triskadecapeptide].

RIPK1_HUMAN
NC score	0.065777 (rank : 489)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	227	Target Neighborhood Hits	891	Shared Neighborhood Hits	49
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

GUC2D_HUMAN
NC score	0.065539 (rank : 490)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

MOS_MOUSE
NC score	0.065528 (rank : 491)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	227	Target Neighborhood Hits	833	Shared Neighborhood Hits	49
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

IRAK1_MOUSE
NC score	0.065177 (rank : 492)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	227	Target Neighborhood Hits	784	Shared Neighborhood Hits	50
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

KSR1_HUMAN
NC score	0.065116 (rank : 493)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	227	Target Neighborhood Hits	867	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

GUC2G_MOUSE
NC score	0.065070 (rank : 494)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	227	Target Neighborhood Hits	644	Shared Neighborhood Hits	46
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANM2_HUMAN
NC score	0.064990 (rank : 495)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	227	Target Neighborhood Hits	175	Shared Neighborhood Hits	47
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

MAMC1_HUMAN
NC score	0.064928 (rank : 496)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	227	Target Neighborhood Hits	357	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

KSR1_MOUSE
NC score	0.064723 (rank : 497)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	227	Target Neighborhood Hits	870	Shared Neighborhood Hits	53
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

CO7A1_HUMAN
NC score	0.064617 (rank : 498)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	227	Target Neighborhood Hits	807	Shared Neighborhood Hits	16
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

ES8L1_HUMAN
NC score	0.064461 (rank : 499)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

BMR1B_HUMAN
NC score	0.064227 (rank : 500)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	227	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

TARSH_HUMAN
NC score	0.064209 (rank : 501)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	227	Target Neighborhood Hits	768	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ABI1_MOUSE
NC score	0.064182 (rank : 502)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	227	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

BMR1B_MOUSE
NC score	0.064117 (rank : 503)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	227	Target Neighborhood Hits	758	Shared Neighborhood Hits	49
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

MYOM1_MOUSE
NC score	0.064023 (rank : 504)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	227	Target Neighborhood Hits	415	Shared Neighborhood Hits	15
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

KSR2_HUMAN
NC score	0.064018 (rank : 505)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	227	Target Neighborhood Hits	920	Shared Neighborhood Hits	53
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

M3K12_HUMAN
NC score	0.063959 (rank : 506)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	227	Target Neighborhood Hits	940	Shared Neighborhood Hits	51
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

IRAK3_HUMAN
NC score	0.063928 (rank : 507)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	227	Target Neighborhood Hits	644	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

M3K12_MOUSE
NC score	0.063517 (rank : 508)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	227	Target Neighborhood Hits	957	Shared Neighborhood Hits	51
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CNTN1_MOUSE
NC score	0.063507 (rank : 509)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	227	Target Neighborhood Hits	422	Shared Neighborhood Hits	12
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

RIPK2_MOUSE
NC score	0.063489 (rank : 510)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	227	Target Neighborhood Hits	776	Shared Neighborhood Hits	49
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

TENA_HUMAN
NC score	0.063065 (rank : 511)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	227	Target Neighborhood Hits	631	Shared Neighborhood Hits	19
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

M3K13_HUMAN
NC score	0.062882 (rank : 512)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	227	Target Neighborhood Hits	911	Shared Neighborhood Hits	49
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

SOCS5_HUMAN
NC score	0.062611 (rank : 513)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	227	Target Neighborhood Hits	91	Shared Neighborhood Hits	66
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

ITSN2_MOUSE
NC score	0.062579 (rank : 514)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	227	Target Neighborhood Hits	1371	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CIP4_HUMAN
NC score	0.062533 (rank : 515)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	227	Target Neighborhood Hits	374	Shared Neighborhood Hits	45
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

NFASC_HUMAN
NC score	0.062369 (rank : 516)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	227	Target Neighborhood Hits	497	Shared Neighborhood Hits	14
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

RIPK2_HUMAN
NC score	0.062192 (rank : 517)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	227	Target Neighborhood Hits	774	Shared Neighborhood Hits	49
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

ABI3_MOUSE
NC score	0.062187 (rank : 518)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CNTN1_HUMAN
NC score	0.062142 (rank : 519)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	227	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

BMR1A_MOUSE
NC score	0.062141 (rank : 520)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	227	Target Neighborhood Hits	758	Shared Neighborhood Hits	49
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1A_HUMAN
NC score	0.062044 (rank : 521)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	227	Target Neighborhood Hits	759	Shared Neighborhood Hits	49
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

SOCS5_MOUSE
NC score	0.061983 (rank : 522)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	227	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

RIPK3_HUMAN
NC score	0.061827 (rank : 523)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	227	Target Neighborhood Hits	828	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
NC score	0.061644 (rank : 524)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	227	Target Neighborhood Hits	867	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

ABI1_HUMAN
NC score	0.061588 (rank : 525)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	227	Target Neighborhood Hits	257	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI3_HUMAN
NC score	0.061499 (rank : 526)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

COEA1_HUMAN
NC score	0.061387 (rank : 527)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	227	Target Neighborhood Hits	427	Shared Neighborhood Hits	14
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

CNTN3_MOUSE
NC score	0.061306 (rank : 528)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	227	Target Neighborhood Hits	447	Shared Neighborhood Hits	16
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

SH3G3_MOUSE
NC score	0.061159 (rank : 529)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	227	Target Neighborhood Hits	236	Shared Neighborhood Hits	47
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

IRAK1_HUMAN
NC score	0.061040 (rank : 530)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	227	Target Neighborhood Hits	820	Shared Neighborhood Hits	49
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TITIN_HUMAN
NC score	0.061002 (rank : 531)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	227	Target Neighborhood Hits	2923	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

DBNL_HUMAN
NC score	0.060902 (rank : 532)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	227	Target Neighborhood Hits	244	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

M3K7_MOUSE
NC score	0.060811 (rank : 533)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	227	Target Neighborhood Hits	892	Shared Neighborhood Hits	51
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.060777 (rank : 534)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	227	Target Neighborhood Hits	892	Shared Neighborhood Hits	51
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

ANM2_MOUSE
NC score	0.060761 (rank : 535)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	227	Target Neighborhood Hits	175	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SH3G2_HUMAN
NC score	0.060230 (rank : 536)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	227	Target Neighborhood Hits	324	Shared Neighborhood Hits	51
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

LASP1_HUMAN
NC score	0.060223 (rank : 537)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	227	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CNTN6_HUMAN
NC score	0.060210 (rank : 538)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	227	Target Neighborhood Hits	422	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

NFASC_MOUSE
NC score	0.059969 (rank : 539)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	227	Target Neighborhood Hits	475	Shared Neighborhood Hits	14
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

MYOM1_HUMAN
NC score	0.059885 (rank : 540)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	227	Target Neighborhood Hits	405	Shared Neighborhood Hits	12
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

IRAK4_HUMAN
NC score	0.059851 (rank : 541)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	227	Target Neighborhood Hits	816	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

DBNL_MOUSE
NC score	0.059806 (rank : 542)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	227	Target Neighborhood Hits	306	Shared Neighborhood Hits	48
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ROBO3_MOUSE
NC score	0.059640 (rank : 543)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	227	Target Neighborhood Hits	524	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

LASP1_MOUSE
NC score	0.059594 (rank : 544)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	227	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ITSN1_MOUSE
NC score	0.059322 (rank : 545)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	227	Target Neighborhood Hits	1669	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

LIMK1_HUMAN
NC score	0.058836 (rank : 546)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	227	Target Neighborhood Hits	1005	Shared Neighborhood Hits	51
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.058825 (rank : 547)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	227	Target Neighborhood Hits	1008	Shared Neighborhood Hits	51
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

NEBL_HUMAN
NC score	0.058807 (rank : 548)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	227	Target Neighborhood Hits	457	Shared Neighborhood Hits	54
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

ACVL1_HUMAN
NC score	0.058636 (rank : 549)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	227	Target Neighborhood Hits	716	Shared Neighborhood Hits	49
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

CNTN3_HUMAN
NC score	0.058629 (rank : 550)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	227	Target Neighborhood Hits	455	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

TESK2_HUMAN
NC score	0.058621 (rank : 551)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	227	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

LIFR_MOUSE
NC score	0.058571 (rank : 552)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	227	Target Neighborhood Hits	127	Shared Neighborhood Hits	11
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

ACVL1_MOUSE
NC score	0.058511 (rank : 553)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	227	Target Neighborhood Hits	739	Shared Neighborhood Hits	49
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

PUNC_HUMAN
NC score	0.058452 (rank : 554)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	227	Target Neighborhood Hits	449	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ITSN1_HUMAN
NC score	0.058282 (rank : 555)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	227	Target Neighborhood Hits	1757	Shared Neighborhood Hits	78
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3G1_MOUSE
NC score	0.058043 (rank : 556)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	227	Target Neighborhood Hits	291	Shared Neighborhood Hits	50
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ACV1C_HUMAN
NC score	0.057910 (rank : 557)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	227	Target Neighborhood Hits	709	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

TESK2_MOUSE
NC score	0.057794 (rank : 558)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	227	Target Neighborhood Hits	833	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

LIMK2_MOUSE
NC score	0.057612 (rank : 559)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	227	Target Neighborhood Hits	998	Shared Neighborhood Hits	51
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TOPK_MOUSE
NC score	0.057590 (rank : 560)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	227	Target Neighborhood Hits	618	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TOPK_HUMAN
NC score	0.057572 (rank : 561)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	227	Target Neighborhood Hits	605	Shared Neighborhood Hits	47
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

RHG04_HUMAN
NC score	0.057561 (rank : 562)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ACV1C_MOUSE
NC score	0.057421 (rank : 563)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

IRAK4_MOUSE
NC score	0.057376 (rank : 564)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	227	Target Neighborhood Hits	820	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

TENA_MOUSE
NC score	0.057328 (rank : 565)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	227	Target Neighborhood Hits	596	Shared Neighborhood Hits	17
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

RIPK5_HUMAN
NC score	0.056984 (rank : 566)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	227	Target Neighborhood Hits	864	Shared Neighborhood Hits	50
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

LIMK2_HUMAN
NC score	0.056952 (rank : 567)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	227	Target Neighborhood Hits	986	Shared Neighborhood Hits	51
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RIPK5_MOUSE
NC score	0.056875 (rank : 568)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	227	Target Neighborhood Hits	874	Shared Neighborhood Hits	51
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

TGFR1_HUMAN
NC score	0.056788 (rank : 569)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	227	Target Neighborhood Hits	755	Shared Neighborhood Hits	49
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.056713 (rank : 570)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	227	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

SH3G3_HUMAN
NC score	0.056422 (rank : 571)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	227	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

TESK1_HUMAN
NC score	0.056230 (rank : 572)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	227	Target Neighborhood Hits	864	Shared Neighborhood Hits	50
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

SRGP2_HUMAN
NC score	0.056116 (rank : 573)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	227	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

COKA1_HUMAN
NC score	0.055987 (rank : 574)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	227	Target Neighborhood Hits	403	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

SH3G1_HUMAN
NC score	0.055933 (rank : 575)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

TESK1_MOUSE
NC score	0.055867 (rank : 576)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	227	Target Neighborhood Hits	862	Shared Neighborhood Hits	49
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

MYOM2_HUMAN
NC score	0.055705 (rank : 577)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	227	Target Neighborhood Hits	341	Shared Neighborhood Hits	15
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

ACV1B_MOUSE
NC score	0.055481 (rank : 578)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	227	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.055434 (rank : 579)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	227	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

SRGP2_MOUSE
NC score	0.055404 (rank : 580)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	227	Target Neighborhood Hits	324	Shared Neighborhood Hits	56
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SH3G2_MOUSE
NC score	0.055333 (rank : 581)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	227	Target Neighborhood Hits	319	Shared Neighborhood Hits	45
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

AMHR2_HUMAN
NC score	0.055179 (rank : 582)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

CAH14_HUMAN
NC score	0.054998 (rank : 583)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	227	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULX7, Q5TB24, Q8NCF4	Gene names	CA14
Domain Architecture
Description	Carbonic anhydrase 14 precursor (EC 4.2.1.1) (Carbonic anhydrase XIV) (Carbonate dehydratase XIV) (CA-XIV).

IRAK2_HUMAN
NC score	0.054861 (rank : 584)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	227	Target Neighborhood Hits	714	Shared Neighborhood Hits	46
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ARHG4_HUMAN
NC score	0.054858 (rank : 585)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	227	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TNI3K_MOUSE
NC score	0.054237 (rank : 586)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	227	Target Neighborhood Hits	1079	Shared Neighborhood Hits	49
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_HUMAN
NC score	0.054120 (rank : 587)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	227	Target Neighborhood Hits	1084	Shared Neighborhood Hits	49
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CAH4_HUMAN
NC score	0.053798 (rank : 588)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	227	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	P22748	Gene names	CA4
Domain Architecture
Description	Carbonic anhydrase 4 precursor (EC 4.2.1.1) (Carbonic anhydrase IV) (Carbonate dehydratase IV) (CA-IV).

ACVR1_MOUSE
NC score	0.053683 (rank : 589)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	227	Target Neighborhood Hits	768	Shared Neighborhood Hits	49
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

CNTN4_HUMAN
NC score	0.053518 (rank : 590)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	227	Target Neighborhood Hits	449	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CAH12_HUMAN
NC score	0.053455 (rank : 591)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	227	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	O43570, Q53YE5, Q9BWG2	Gene names	CA12
Domain Architecture
Description	Carbonic anhydrase 12 precursor (EC 4.2.1.1) (Carbonic anhydrase XII) (Carbonate dehydratase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3).

ACVR1_HUMAN
NC score	0.053409 (rank : 592)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	227	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

CAH12_MOUSE
NC score	0.053369 (rank : 593)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	227	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CI85, Q8BKG6	Gene names	Ca12, Car12
Domain Architecture
Description	Carbonic anhydrase 12 precursor (EC 4.2.1.1) (Carbonic anhydrase XII) (Carbonate dehydratase XII) (CA-XII).

PUNC_MOUSE
NC score	0.053359 (rank : 594)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	227	Target Neighborhood Hits	501	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

EPS8_MOUSE
NC score	0.053300 (rank : 595)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	227	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ROBO3_HUMAN
NC score	0.053228 (rank : 596)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	227	Target Neighborhood Hits	570	Shared Neighborhood Hits	16
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

CNTN4_MOUSE
NC score	0.052983 (rank : 597)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	227	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CAH4_MOUSE
NC score	0.052885 (rank : 598)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	227	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q64444	Gene names	Ca4, Car4
Domain Architecture
Description	Carbonic anhydrase 4 precursor (EC 4.2.1.1) (Carbonic anhydrase IV) (Carbonate dehydratase IV) (CA-IV).

PEX13_HUMAN
NC score	0.052877 (rank : 599)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	31
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CNTN6_MOUSE
NC score	0.052738 (rank : 600)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	227	Target Neighborhood Hits	429	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CAH15_MOUSE
NC score	0.052667 (rank : 601)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	227	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q99N23	Gene names	Ca15, Car15
Domain Architecture
Description	Carbonic anhydrase 15 precursor (EC 4.2.1.1) (Carbonic anhydrase XV) (Carbonate dehydratase XV) (CA-XV).

FNBP2_HUMAN
NC score	0.052521 (rank : 602)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	227	Target Neighborhood Hits	432	Shared Neighborhood Hits	56
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ES8L1_MOUSE
NC score	0.052450 (rank : 603)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	227	Target Neighborhood Hits	143	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

CAH14_MOUSE
NC score	0.052328 (rank : 604)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	227	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVT6	Gene names	Ca14, Car14, Catm
Domain Architecture
Description	Carbonic anhydrase 14 precursor (EC 4.2.1.1) (Carbonic anhydrase XIV) (Carbonate dehydratase XIV) (CA-XIV).

AB1IP_HUMAN
NC score	0.052034 (rank : 605)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	227	Target Neighborhood Hits	213	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

CHL1_HUMAN
NC score	0.052001 (rank : 606)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	227	Target Neighborhood Hits	413	Shared Neighborhood Hits	11
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

SRGP1_HUMAN
NC score	0.051849 (rank : 607)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	227	Target Neighborhood Hits	390	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

IL6RB_HUMAN
NC score	0.051477 (rank : 608)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	227	Target Neighborhood Hits	181	Shared Neighborhood Hits	9
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

KALM_HUMAN
NC score	0.051416 (rank : 609)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	227	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

EPS8_HUMAN
NC score	0.051199 (rank : 610)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

CAH6_MOUSE
NC score	0.051142 (rank : 611)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	227	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	P18761, O88625	Gene names	Ca6, Car6
Domain Architecture
Description	Carbonic anhydrase 6 precursor (EC 4.2.1.1) (Carbonic anhydrase VI) (Carbonate dehydratase VI) (CA-VI) (Secreted carbonic anhydrase) (Salivary carbonic anhydrase).

AB1IP_MOUSE
NC score	0.051069 (rank : 612)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	227	Target Neighborhood Hits	181	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

PDC6I_MOUSE
NC score	0.050492 (rank : 613)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	227	Target Neighborhood Hits	275	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

CHL1_MOUSE
NC score	0.050458 (rank : 614)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	227	Target Neighborhood Hits	402	Shared Neighborhood Hits	14
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

ROBO2_MOUSE
NC score	0.050440 (rank : 615)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	227	Target Neighborhood Hits	504	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

LRRK1_MOUSE
NC score	0.050122 (rank : 616)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	227	Target Neighborhood Hits	1267	Shared Neighborhood Hits	49
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MYLK_HUMAN
NC score	0.050098 (rank : 617)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	227	Target Neighborhood Hits	1328	Shared Neighborhood Hits	61
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

DUET_HUMAN
NC score	0.050067 (rank : 618)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	227	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ROBO2_HUMAN
NC score	0.050008 (rank : 619)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	227	Target Neighborhood Hits	479	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

RHG25_HUMAN
NC score	0.024364 (rank : 620)	θ value	0.813845 (rank : 194)
Query Neighborhood Hits	227	Target Neighborhood Hits	550	Shared Neighborhood Hits	18
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ROCK1_HUMAN
NC score	0.019164 (rank : 621)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	227	Target Neighborhood Hits	2000	Shared Neighborhood Hits	64
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
NC score	0.018931 (rank : 622)	θ value	5.27518 (rank : 224)
Query Neighborhood Hits	227	Target Neighborhood Hits	2126	Shared Neighborhood Hits	66
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

DZIP1_HUMAN
NC score	0.012542 (rank : 623)	θ value	1.38821 (rank : 204)
Query Neighborhood Hits	227	Target Neighborhood Hits	675	Shared Neighborhood Hits	14
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

STAT4_MOUSE
NC score	0.012435 (rank : 624)	θ value	0.813845 (rank : 197)
Query Neighborhood Hits	227	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	P42228	Gene names	Stat4
Domain Architecture
Description	Signal transducer and activator of transcription 4.

STAT4_HUMAN
NC score	0.011612 (rank : 625)	θ value	1.06291 (rank : 203)
Query Neighborhood Hits	227	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q14765, Q96NZ6	Gene names	STAT4
Domain Architecture
Description	Signal transducer and activator of transcription 4.

SIA8C_MOUSE
NC score	0.010261 (rank : 626)	θ value	1.81305 (rank : 209)
Query Neighborhood Hits	227	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q64689	Gene names	St8sia3, Siat8c
Domain Architecture
Description	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase (EC 2.4.99.-) (ST8 alpha-N-acetyl-neuraminide alpha-2,8- sialyltransferase 3) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8- sialyltransferase III) (ST8Sia III).

SIA8C_HUMAN
NC score	0.010082 (rank : 627)	θ value	1.81305 (rank : 208)
Query Neighborhood Hits	227	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	O43173, Q9NS41	Gene names	ST8SIA3, SIAT8C
Domain Architecture
Description	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase (EC 2.4.99.-) (ST8 alpha-N-acetyl-neuraminide alpha-2,8- sialyltransferase 3) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8- sialyltransferase III) (ST8Sia III).

ZWINT_MOUSE
NC score	0.009249 (rank : 628)	θ value	0.813845 (rank : 198)
Query Neighborhood Hits	227	Target Neighborhood Hits	497	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

RPF53_HUMAN
NC score	0.008975 (rank : 629)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	227	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9GZS1, Q5VZT3, Q8NBA9, Q96L20	Gene names	PRAF1, PAF53
Domain Architecture	No domain graphic available
Description	DNA-directed RNA polymerase I-associated factor 53 kDa subunit (EC 2.7.7.6) (RNA polymerase I-associated factor 1).

HM20A_HUMAN
NC score	0.007271 (rank : 630)	θ value	3.0926 (rank : 216)
Query Neighborhood Hits	227	Target Neighborhood Hits	343	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NP66, Q53G31, Q9NSF6	Gene names	HMG20A, HMGX1
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein HMGX1).

HM20A_MOUSE
NC score	0.007186 (rank : 631)	θ value	3.0926 (rank : 217)
Query Neighborhood Hits	227	Target Neighborhood Hits	348	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DC33, Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2	Gene names	Hmg20a, Ibraf
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (iBRAF) (Inhibitor of BRAF35) (HMG domain protein HMGX1).

NALP5_MOUSE
NC score	0.003596 (rank : 632)	θ value	1.06291 (rank : 202)
Query Neighborhood Hits	227	Target Neighborhood Hits	560	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

CCD19_HUMAN
NC score	0.003245 (rank : 633)	θ value	1.81305 (rank : 206)
Query Neighborhood Hits	227	Target Neighborhood Hits	639	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

LUZP1_HUMAN
NC score	0.002603 (rank : 634)	θ value	1.81305 (rank : 207)
Query Neighborhood Hits	227	Target Neighborhood Hits	739	Shared Neighborhood Hits	13
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

ITA9_HUMAN
NC score	0.001882 (rank : 635)	θ value	4.03905 (rank : 221)
Query Neighborhood Hits	227	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q13797, Q14638	Gene names	ITGA9
Domain Architecture
Description	Integrin alpha-9 precursor (Integrin alpha-RLC).

LUZP1_MOUSE
NC score	0.000912 (rank : 636)	θ value	2.36792 (rank : 212)
Query Neighborhood Hits	227	Target Neighborhood Hits	940	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

GOGA4_HUMAN
NC score	-0.003549 (rank : 637)	θ value	4.03905 (rank : 220)
Query Neighborhood Hits	227	Target Neighborhood Hits	2034	Shared Neighborhood Hits	27
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).