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Network neighborhood for query Sequence : DSCAM_HUMAN

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DSCAM_HUMAN
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DSCAM_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	524	Target Neighborhood Hits	524	Shared Neighborhood Hits	524
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
θ value	0 (rank : 2)	NC score	0.982940 (rank : 2)
Query Neighborhood Hits	524	Target Neighborhood Hits	589	Shared Neighborhood Hits	428
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

SDK2_HUMAN
θ value	8.20983e-86 (rank : 3)	NC score	0.934649 (rank : 3)
Query Neighborhood Hits	524	Target Neighborhood Hits	495	Shared Neighborhood Hits	397
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	4.50487e-84 (rank : 4)	NC score	0.933408 (rank : 4)
Query Neighborhood Hits	524	Target Neighborhood Hits	480	Shared Neighborhood Hits	395
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK1_MOUSE
θ value	3.34088e-79 (rank : 5)	NC score	0.931740 (rank : 5)
Query Neighborhood Hits	524	Target Neighborhood Hits	495	Shared Neighborhood Hits	389
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_HUMAN
θ value	9.7205e-79 (rank : 6)	NC score	0.931640 (rank : 7)
Query Neighborhood Hits	524	Target Neighborhood Hits	511	Shared Neighborhood Hits	388
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

DCC_MOUSE
θ value	5.34618e-69 (rank : 7)	NC score	0.913626 (rank : 29)
Query Neighborhood Hits	524	Target Neighborhood Hits	896	Shared Neighborhood Hits	414
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DCC_HUMAN
θ value	1.00825e-67 (rank : 8)	NC score	0.931651 (rank : 6)
Query Neighborhood Hits	524	Target Neighborhood Hits	583	Shared Neighborhood Hits	410
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

TITIN_HUMAN
θ value	1.11475e-66 (rank : 9)	NC score	0.573024 (rank : 147)
Query Neighborhood Hits	524	Target Neighborhood Hits	2923	Shared Neighborhood Hits	473
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

NEO1_HUMAN
θ value	3.03575e-64 (rank : 10)	NC score	0.929122 (rank : 8)
Query Neighborhood Hits	524	Target Neighborhood Hits	530	Shared Neighborhood Hits	394
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	2.56992e-63 (rank : 11)	NC score	0.927023 (rank : 9)
Query Neighborhood Hits	524	Target Neighborhood Hits	523	Shared Neighborhood Hits	393
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

HMCN1_HUMAN
θ value	3.35642e-63 (rank : 12)	NC score	0.649690 (rank : 121)
Query Neighborhood Hits	524	Target Neighborhood Hits	983	Shared Neighborhood Hits	392
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

L1CAM_HUMAN
θ value	1.41016e-61 (rank : 13)	NC score	0.921333 (rank : 14)
Query Neighborhood Hits	524	Target Neighborhood Hits	457	Shared Neighborhood Hits	392
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

ROBO1_MOUSE
θ value	1.19377e-60 (rank : 14)	NC score	0.912974 (rank : 31)
Query Neighborhood Hits	524	Target Neighborhood Hits	559	Shared Neighborhood Hits	401
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO1_HUMAN
θ value	4.53632e-60 (rank : 15)	NC score	0.910060 (rank : 34)
Query Neighborhood Hits	524	Target Neighborhood Hits	529	Shared Neighborhood Hits	394
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

L1CAM_MOUSE
θ value	7.73779e-60 (rank : 16)	NC score	0.923695 (rank : 12)
Query Neighborhood Hits	524	Target Neighborhood Hits	457	Shared Neighborhood Hits	396
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN3_MOUSE
θ value	1.61343e-57 (rank : 17)	NC score	0.913689 (rank : 28)
Query Neighborhood Hits	524	Target Neighborhood Hits	447	Shared Neighborhood Hits	388
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

NRCAM_MOUSE
θ value	4.69435e-57 (rank : 18)	NC score	0.924631 (rank : 11)
Query Neighborhood Hits	524	Target Neighborhood Hits	432	Shared Neighborhood Hits	371
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

CNTN5_MOUSE
θ value	1.0458e-56 (rank : 19)	NC score	0.916170 (rank : 22)
Query Neighborhood Hits	524	Target Neighborhood Hits	434	Shared Neighborhood Hits	382
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

ROBO2_HUMAN
θ value	1.36585e-56 (rank : 20)	NC score	0.917730 (rank : 19)
Query Neighborhood Hits	524	Target Neighborhood Hits	479	Shared Neighborhood Hits	398
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

CNTN3_HUMAN
θ value	2.32979e-56 (rank : 21)	NC score	0.917119 (rank : 20)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	399
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN5_HUMAN
θ value	3.0428e-56 (rank : 22)	NC score	0.918412 (rank : 17)
Query Neighborhood Hits	524	Target Neighborhood Hits	446	Shared Neighborhood Hits	390
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

ROBO2_MOUSE
θ value	6.77864e-56 (rank : 23)	NC score	0.917004 (rank : 21)
Query Neighborhood Hits	524	Target Neighborhood Hits	504	Shared Neighborhood Hits	403
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

NFASC_HUMAN
θ value	1.15626e-55 (rank : 24)	NC score	0.924806 (rank : 10)
Query Neighborhood Hits	524	Target Neighborhood Hits	497	Shared Neighborhood Hits	391
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

CNTN4_HUMAN
θ value	1.97229e-55 (rank : 25)	NC score	0.914270 (rank : 27)
Query Neighborhood Hits	524	Target Neighborhood Hits	449	Shared Neighborhood Hits	386
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN2_MOUSE
θ value	2.57589e-55 (rank : 26)	NC score	0.921027 (rank : 15)
Query Neighborhood Hits	524	Target Neighborhood Hits	450	Shared Neighborhood Hits	400
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN4_MOUSE
θ value	4.39379e-55 (rank : 27)	NC score	0.913556 (rank : 30)
Query Neighborhood Hits	524	Target Neighborhood Hits	445	Shared Neighborhood Hits	381
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CHL1_HUMAN
θ value	5.73848e-55 (rank : 28)	NC score	0.914681 (rank : 24)
Query Neighborhood Hits	524	Target Neighborhood Hits	413	Shared Neighborhood Hits	363
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CNTN1_HUMAN
θ value	5.73848e-55 (rank : 29)	NC score	0.914445 (rank : 25)
Query Neighborhood Hits	524	Target Neighborhood Hits	431	Shared Neighborhood Hits	373
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN6_MOUSE
θ value	1.2784e-54 (rank : 30)	NC score	0.908594 (rank : 37)
Query Neighborhood Hits	524	Target Neighborhood Hits	429	Shared Neighborhood Hits	374
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

PTPRD_HUMAN
θ value	4.85792e-54 (rank : 31)	NC score	0.705179 (rank : 88)
Query Neighborhood Hits	524	Target Neighborhood Hits	485	Shared Neighborhood Hits	350
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CNTN1_MOUSE
θ value	2.41096e-53 (rank : 32)	NC score	0.914417 (rank : 26)
Query Neighborhood Hits	524	Target Neighborhood Hits	422	Shared Neighborhood Hits	373
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN2_HUMAN
θ value	1.19655e-52 (rank : 33)	NC score	0.920322 (rank : 16)
Query Neighborhood Hits	524	Target Neighborhood Hits	440	Shared Neighborhood Hits	389
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

NRCAM_HUMAN
θ value	3.48141e-52 (rank : 34)	NC score	0.922692 (rank : 13)
Query Neighborhood Hits	524	Target Neighborhood Hits	439	Shared Neighborhood Hits	385
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

ROBO3_HUMAN
θ value	6.56568e-51 (rank : 35)	NC score	0.916156 (rank : 23)
Query Neighborhood Hits	524	Target Neighborhood Hits	570	Shared Neighborhood Hits	396
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

PTPRF_HUMAN
θ value	5.55816e-50 (rank : 36)	NC score	0.717272 (rank : 80)
Query Neighborhood Hits	524	Target Neighborhood Hits	489	Shared Neighborhood Hits	367
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

CHL1_MOUSE
θ value	7.25919e-50 (rank : 37)	NC score	0.909459 (rank : 35)
Query Neighborhood Hits	524	Target Neighborhood Hits	402	Shared Neighborhood Hits	359
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CNTN6_HUMAN
θ value	9.48078e-50 (rank : 38)	NC score	0.908702 (rank : 36)
Query Neighborhood Hits	524	Target Neighborhood Hits	422	Shared Neighborhood Hits	375
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

PTPRD_MOUSE
θ value	4.40402e-47 (rank : 39)	NC score	0.719456 (rank : 79)
Query Neighborhood Hits	524	Target Neighborhood Hits	491	Shared Neighborhood Hits	358
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRS_HUMAN
θ value	4.86918e-46 (rank : 40)	NC score	0.697745 (rank : 94)
Query Neighborhood Hits	524	Target Neighborhood Hits	472	Shared Neighborhood Hits	347
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

ROBO3_MOUSE
θ value	1.73182e-43 (rank : 41)	NC score	0.911484 (rank : 32)
Query Neighborhood Hits	524	Target Neighborhood Hits	524	Shared Neighborhood Hits	377
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

PGBM_HUMAN
θ value	5.57106e-42 (rank : 42)	NC score	0.654513 (rank : 118)
Query Neighborhood Hits	524	Target Neighborhood Hits	1113	Shared Neighborhood Hits	380
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

PTK7_HUMAN
θ value	8.32485e-38 (rank : 43)	NC score	0.516655 (rank : 160)
Query Neighborhood Hits	524	Target Neighborhood Hits	1103	Shared Neighborhood Hits	358
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

NFASC_MOUSE
θ value	1.57e-36 (rank : 44)	NC score	0.917891 (rank : 18)
Query Neighborhood Hits	524	Target Neighborhood Hits	475	Shared Neighborhood Hits	383
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

PGBM_MOUSE
θ value	1.73584e-35 (rank : 45)	NC score	0.638432 (rank : 125)
Query Neighborhood Hits	524	Target Neighborhood Hits	1073	Shared Neighborhood Hits	373
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

NCAM2_HUMAN
θ value	1.12514e-34 (rank : 46)	NC score	0.888457 (rank : 40)
Query Neighborhood Hits	524	Target Neighborhood Hits	441	Shared Neighborhood Hits	391
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCA11_HUMAN
θ value	9.52487e-34 (rank : 47)	NC score	0.870908 (rank : 43)
Query Neighborhood Hits	524	Target Neighborhood Hits	443	Shared Neighborhood Hits	375
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

PUNC_MOUSE
θ value	2.34606e-32 (rank : 48)	NC score	0.907911 (rank : 38)
Query Neighborhood Hits	524	Target Neighborhood Hits	501	Shared Neighborhood Hits	355
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

NCA11_MOUSE
θ value	1.16434e-31 (rank : 49)	NC score	0.850166 (rank : 48)
Query Neighborhood Hits	524	Target Neighborhood Hits	661	Shared Neighborhood Hits	378
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NCA12_MOUSE
θ value	1.98606e-31 (rank : 50)	NC score	0.865283 (rank : 47)
Query Neighborhood Hits	524	Target Neighborhood Hits	399	Shared Neighborhood Hits	360
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCA12_HUMAN
θ value	2.59387e-31 (rank : 51)	NC score	0.865807 (rank : 46)
Query Neighborhood Hits	524	Target Neighborhood Hits	437	Shared Neighborhood Hits	371
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

PUNC_HUMAN
θ value	2.59387e-31 (rank : 52)	NC score	0.910933 (rank : 33)
Query Neighborhood Hits	524	Target Neighborhood Hits	449	Shared Neighborhood Hits	360
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

NCAM2_MOUSE
θ value	9.8567e-31 (rank : 53)	NC score	0.893208 (rank : 39)
Query Neighborhood Hits	524	Target Neighborhood Hits	472	Shared Neighborhood Hits	397
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

USH2A_HUMAN
θ value	1.73987e-27 (rank : 54)	NC score	0.416455 (rank : 187)
Query Neighborhood Hits	524	Target Neighborhood Hits	600	Shared Neighborhood Hits	170
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

MYLK_HUMAN
θ value	9.54697e-26 (rank : 55)	NC score	0.403445 (rank : 199)
Query Neighborhood Hits	524	Target Neighborhood Hits	1328	Shared Neighborhood Hits	377
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	4.73814e-25 (rank : 56)	NC score	0.400087 (rank : 201)
Query Neighborhood Hits	524	Target Neighborhood Hits	1489	Shared Neighborhood Hits	362
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MDGA1_HUMAN
θ value	1.16704e-23 (rank : 57)	NC score	0.798505 (rank : 59)
Query Neighborhood Hits	524	Target Neighborhood Hits	358	Shared Neighborhood Hits	293
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

CDON_MOUSE
θ value	4.43474e-23 (rank : 58)	NC score	0.872893 (rank : 41)
Query Neighborhood Hits	524	Target Neighborhood Hits	410	Shared Neighborhood Hits	340
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

MAMC1_HUMAN
θ value	9.87957e-23 (rank : 59)	NC score	0.812661 (rank : 50)
Query Neighborhood Hits	524	Target Neighborhood Hits	357	Shared Neighborhood Hits	304
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

OBSCN_HUMAN
θ value	9.87957e-23 (rank : 60)	NC score	0.425762 (rank : 186)
Query Neighborhood Hits	524	Target Neighborhood Hits	1931	Shared Neighborhood Hits	404
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

MAMC1_MOUSE
θ value	1.29031e-22 (rank : 61)	NC score	0.811052 (rank : 52)
Query Neighborhood Hits	524	Target Neighborhood Hits	357	Shared Neighborhood Hits	302
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

FINC_MOUSE
θ value	3.75424e-22 (rank : 62)	NC score	0.528429 (rank : 157)
Query Neighborhood Hits	524	Target Neighborhood Hits	309	Shared Neighborhood Hits	165
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

LRIG2_HUMAN
θ value	6.40375e-22 (rank : 63)	NC score	0.620371 (rank : 132)
Query Neighborhood Hits	524	Target Neighborhood Hits	595	Shared Neighborhood Hits	313
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

LRIG2_MOUSE
θ value	8.36355e-22 (rank : 64)	NC score	0.617989 (rank : 133)
Query Neighborhood Hits	524	Target Neighborhood Hits	586	Shared Neighborhood Hits	314
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

CDON_HUMAN
θ value	1.86321e-21 (rank : 65)	NC score	0.871115 (rank : 42)
Query Neighborhood Hits	524	Target Neighborhood Hits	412	Shared Neighborhood Hits	332
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

NPHN_HUMAN
θ value	3.17815e-21 (rank : 66)	NC score	0.808651 (rank : 54)
Query Neighborhood Hits	524	Target Neighborhood Hits	362	Shared Neighborhood Hits	308
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

SPEG_MOUSE
θ value	1.5773e-20 (rank : 67)	NC score	0.394961 (rank : 204)
Query Neighborhood Hits	524	Target Neighborhood Hits	1959	Shared Neighborhood Hits	347
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

USH2A_MOUSE
θ value	1.5773e-20 (rank : 68)	NC score	0.398331 (rank : 202)
Query Neighborhood Hits	524	Target Neighborhood Hits	626	Shared Neighborhood Hits	166
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

MYPC2_HUMAN
θ value	3.51386e-20 (rank : 69)	NC score	0.709505 (rank : 86)
Query Neighborhood Hits	524	Target Neighborhood Hits	316	Shared Neighborhood Hits	280
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

NPHN_MOUSE
θ value	1.02238e-19 (rank : 70)	NC score	0.793033 (rank : 64)
Query Neighborhood Hits	524	Target Neighborhood Hits	370	Shared Neighborhood Hits	309
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

LRIG1_HUMAN
θ value	1.33526e-19 (rank : 71)	NC score	0.626784 (rank : 129)
Query Neighborhood Hits	524	Target Neighborhood Hits	654	Shared Neighborhood Hits	331
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

LRIG3_MOUSE
θ value	2.27762e-19 (rank : 72)	NC score	0.596054 (rank : 140)
Query Neighborhood Hits	524	Target Neighborhood Hits	611	Shared Neighborhood Hits	320
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

SPEG_HUMAN
θ value	8.65492e-19 (rank : 73)	NC score	0.391323 (rank : 208)
Query Neighborhood Hits	524	Target Neighborhood Hits	1762	Shared Neighborhood Hits	342
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MYPC2_MOUSE
θ value	1.13037e-18 (rank : 74)	NC score	0.707852 (rank : 87)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	267
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

LRIG3_HUMAN
θ value	1.92812e-18 (rank : 75)	NC score	0.589205 (rank : 142)
Query Neighborhood Hits	524	Target Neighborhood Hits	601	Shared Neighborhood Hits	317
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

VGFR1_HUMAN
θ value	7.32683e-18 (rank : 76)	NC score	0.434497 (rank : 182)
Query Neighborhood Hits	524	Target Neighborhood Hits	1109	Shared Neighborhood Hits	340
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

MUSK_HUMAN
θ value	3.63628e-17 (rank : 77)	NC score	0.468004 (rank : 170)
Query Neighborhood Hits	524	Target Neighborhood Hits	1074	Shared Neighborhood Hits	345
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

ROBO4_HUMAN
θ value	3.63628e-17 (rank : 78)	NC score	0.809339 (rank : 53)
Query Neighborhood Hits	524	Target Neighborhood Hits	364	Shared Neighborhood Hits	274
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

BOC_HUMAN
θ value	4.74913e-17 (rank : 79)	NC score	0.870036 (rank : 44)
Query Neighborhood Hits	524	Target Neighborhood Hits	543	Shared Neighborhood Hits	360
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

KIRR3_HUMAN
θ value	4.74913e-17 (rank : 80)	NC score	0.693570 (rank : 97)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	255
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

MERTK_HUMAN
θ value	4.74913e-17 (rank : 81)	NC score	0.323627 (rank : 261)
Query Neighborhood Hits	524	Target Neighborhood Hits	988	Shared Neighborhood Hits	266
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MYPN_HUMAN
θ value	6.20254e-17 (rank : 82)	NC score	0.800128 (rank : 58)
Query Neighborhood Hits	524	Target Neighborhood Hits	418	Shared Neighborhood Hits	287
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

FINC_HUMAN
θ value	8.10077e-17 (rank : 83)	NC score	0.517217 (rank : 159)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	171
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

MUSK_MOUSE
θ value	8.10077e-17 (rank : 84)	NC score	0.468294 (rank : 169)
Query Neighborhood Hits	524	Target Neighborhood Hits	1057	Shared Neighborhood Hits	339
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYPC1_HUMAN
θ value	8.10077e-17 (rank : 85)	NC score	0.714874 (rank : 81)
Query Neighborhood Hits	524	Target Neighborhood Hits	303	Shared Neighborhood Hits	277
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

BOC_MOUSE
θ value	1.058e-16 (rank : 86)	NC score	0.867960 (rank : 45)
Query Neighborhood Hits	524	Target Neighborhood Hits	433	Shared Neighborhood Hits	347
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

KIRR3_MOUSE
θ value	2.35696e-16 (rank : 87)	NC score	0.685936 (rank : 102)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	246
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

LRIG1_MOUSE
θ value	2.35696e-16 (rank : 88)	NC score	0.611220 (rank : 134)
Query Neighborhood Hits	524	Target Neighborhood Hits	627	Shared Neighborhood Hits	324
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

NTRI_MOUSE
θ value	2.35696e-16 (rank : 89)	NC score	0.791984 (rank : 66)
Query Neighborhood Hits	524	Target Neighborhood Hits	342	Shared Neighborhood Hits	312
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

MYPN_MOUSE
θ value	3.07829e-16 (rank : 90)	NC score	0.789978 (rank : 67)
Query Neighborhood Hits	524	Target Neighborhood Hits	421	Shared Neighborhood Hits	287
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

ROBO4_MOUSE
θ value	4.02038e-16 (rank : 91)	NC score	0.811748 (rank : 51)
Query Neighborhood Hits	524	Target Neighborhood Hits	358	Shared Neighborhood Hits	283
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

CEAM5_HUMAN
θ value	5.25075e-16 (rank : 92)	NC score	0.679944 (rank : 108)
Query Neighborhood Hits	524	Target Neighborhood Hits	343	Shared Neighborhood Hits	284
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

NTRI_HUMAN
θ value	5.25075e-16 (rank : 93)	NC score	0.788900 (rank : 69)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	313
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

TYRO3_HUMAN
θ value	8.95645e-16 (rank : 94)	NC score	0.359522 (rank : 228)
Query Neighborhood Hits	524	Target Neighborhood Hits	995	Shared Neighborhood Hits	283
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

LSAMP_HUMAN
θ value	1.16975e-15 (rank : 95)	NC score	0.804831 (rank : 56)
Query Neighborhood Hits	524	Target Neighborhood Hits	347	Shared Neighborhood Hits	309
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

LSAMP_MOUSE
θ value	1.52774e-15 (rank : 96)	NC score	0.805833 (rank : 55)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	307
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

FSTL4_MOUSE
θ value	1.99529e-15 (rank : 97)	NC score	0.698071 (rank : 93)
Query Neighborhood Hits	524	Target Neighborhood Hits	333	Shared Neighborhood Hits	261
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

SN_MOUSE
θ value	1.99529e-15 (rank : 98)	NC score	0.720434 (rank : 78)
Query Neighborhood Hits	524	Target Neighborhood Hits	416	Shared Neighborhood Hits	300
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

OPCM_HUMAN
θ value	2.60593e-15 (rank : 99)	NC score	0.795612 (rank : 63)
Query Neighborhood Hits	524	Target Neighborhood Hits	332	Shared Neighborhood Hits	306
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

MYOM2_HUMAN
θ value	3.40345e-15 (rank : 100)	NC score	0.759179 (rank : 71)
Query Neighborhood Hits	524	Target Neighborhood Hits	341	Shared Neighborhood Hits	299
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MERTK_MOUSE
θ value	7.58209e-15 (rank : 101)	NC score	0.315076 (rank : 266)
Query Neighborhood Hits	524	Target Neighborhood Hits	974	Shared Neighborhood Hits	262
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

FNDC3_HUMAN
θ value	3.76295e-14 (rank : 102)	NC score	0.654961 (rank : 116)
Query Neighborhood Hits	524	Target Neighborhood Hits	196	Shared Neighborhood Hits	155
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FSTL4_HUMAN
θ value	3.76295e-14 (rank : 103)	NC score	0.704019 (rank : 89)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	268
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

VCAM1_HUMAN
θ value	3.76295e-14 (rank : 104)	NC score	0.754242 (rank : 72)
Query Neighborhood Hits	524	Target Neighborhood Hits	352	Shared Neighborhood Hits	274
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

DUET_HUMAN
θ value	6.41864e-14 (rank : 105)	NC score	0.278614 (rank : 301)
Query Neighborhood Hits	524	Target Neighborhood Hits	1220	Shared Neighborhood Hits	282
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

MYPC3_MOUSE
θ value	6.41864e-14 (rank : 106)	NC score	0.680508 (rank : 107)
Query Neighborhood Hits	524	Target Neighborhood Hits	310	Shared Neighborhood Hits	272
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

VCAM1_MOUSE
θ value	1.09485e-13 (rank : 107)	NC score	0.760892 (rank : 70)
Query Neighborhood Hits	524	Target Neighborhood Hits	320	Shared Neighborhood Hits	272
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

OBSL1_HUMAN
θ value	1.42992e-13 (rank : 108)	NC score	0.826461 (rank : 49)
Query Neighborhood Hits	524	Target Neighborhood Hits	354	Shared Neighborhood Hits	293
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

COEA1_MOUSE
θ value	3.18553e-13 (rank : 109)	NC score	0.352098 (rank : 238)
Query Neighborhood Hits	524	Target Neighborhood Hits	402	Shared Neighborhood Hits	114
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

MYOM1_HUMAN
θ value	3.18553e-13 (rank : 110)	NC score	0.748680 (rank : 73)
Query Neighborhood Hits	524	Target Neighborhood Hits	405	Shared Neighborhood Hits	306
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYPC3_HUMAN
θ value	3.18553e-13 (rank : 111)	NC score	0.683275 (rank : 104)
Query Neighborhood Hits	524	Target Neighborhood Hits	318	Shared Neighborhood Hits	272
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

PTPRM_MOUSE
θ value	3.18553e-13 (rank : 112)	NC score	0.341562 (rank : 248)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	154
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

VGFR1_MOUSE
θ value	3.18553e-13 (rank : 113)	NC score	0.429959 (rank : 184)
Query Neighborhood Hits	524	Target Neighborhood Hits	1118	Shared Neighborhood Hits	340
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

FCRL5_HUMAN
θ value	4.16044e-13 (rank : 114)	NC score	0.634326 (rank : 126)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	226
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

PTPRM_HUMAN
θ value	4.16044e-13 (rank : 115)	NC score	0.345391 (rank : 242)
Query Neighborhood Hits	524	Target Neighborhood Hits	244	Shared Neighborhood Hits	155
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

SN_HUMAN
θ value	9.26847e-13 (rank : 116)	NC score	0.714392 (rank : 82)
Query Neighborhood Hits	524	Target Neighborhood Hits	434	Shared Neighborhood Hits	302
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

CEAM1_MOUSE
θ value	1.2105e-12 (rank : 117)	NC score	0.657701 (rank : 115)
Query Neighborhood Hits	524	Target Neighborhood Hits	326	Shared Neighborhood Hits	273
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

TYRO3_MOUSE
θ value	1.2105e-12 (rank : 118)	NC score	0.355625 (rank : 231)
Query Neighborhood Hits	524	Target Neighborhood Hits	1007	Shared Neighborhood Hits	287
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

KIRR1_HUMAN
θ value	2.0648e-12 (rank : 119)	NC score	0.685955 (rank : 101)
Query Neighborhood Hits	524	Target Neighborhood Hits	401	Shared Neighborhood Hits	275
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

TMIGD_MOUSE
θ value	2.69671e-12 (rank : 120)	NC score	0.675920 (rank : 109)
Query Neighborhood Hits	524	Target Neighborhood Hits	234	Shared Neighborhood Hits	224
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

KIRR1_MOUSE
θ value	3.52202e-12 (rank : 121)	NC score	0.683643 (rank : 103)
Query Neighborhood Hits	524	Target Neighborhood Hits	403	Shared Neighborhood Hits	275
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

NEGR1_MOUSE
θ value	3.52202e-12 (rank : 122)	NC score	0.789377 (rank : 68)
Query Neighborhood Hits	524	Target Neighborhood Hits	349	Shared Neighborhood Hits	303
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NEGR1_HUMAN
θ value	4.59992e-12 (rank : 123)	NC score	0.792509 (rank : 65)
Query Neighborhood Hits	524	Target Neighborhood Hits	346	Shared Neighborhood Hits	304
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

FGRL1_HUMAN
θ value	6.00763e-12 (rank : 124)	NC score	0.803931 (rank : 57)
Query Neighborhood Hits	524	Target Neighborhood Hits	335	Shared Neighborhood Hits	285
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

SORL_HUMAN
θ value	6.00763e-12 (rank : 125)	NC score	0.256435 (rank : 323)
Query Neighborhood Hits	524	Target Neighborhood Hits	440	Shared Neighborhood Hits	128
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

KIRR2_HUMAN
θ value	7.84624e-12 (rank : 126)	NC score	0.727914 (rank : 75)
Query Neighborhood Hits	524	Target Neighborhood Hits	321	Shared Neighborhood Hits	255
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

MUC18_HUMAN
θ value	7.84624e-12 (rank : 127)	NC score	0.697663 (rank : 95)
Query Neighborhood Hits	524	Target Neighborhood Hits	275	Shared Neighborhood Hits	236
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

FGFR1_HUMAN
θ value	1.02475e-11 (rank : 128)	NC score	0.354543 (rank : 235)
Query Neighborhood Hits	524	Target Neighborhood Hits	1069	Shared Neighborhood Hits	301
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

ITB4_HUMAN
θ value	1.02475e-11 (rank : 129)	NC score	0.379219 (rank : 216)
Query Neighborhood Hits	524	Target Neighborhood Hits	458	Shared Neighborhood Hits	156
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

KIRR2_MOUSE
θ value	1.02475e-11 (rank : 130)	NC score	0.724598 (rank : 76)
Query Neighborhood Hits	524	Target Neighborhood Hits	326	Shared Neighborhood Hits	254
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

VGFR2_MOUSE
θ value	1.33837e-11 (rank : 131)	NC score	0.410436 (rank : 192)
Query Neighborhood Hits	524	Target Neighborhood Hits	1089	Shared Neighborhood Hits	330
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

FNDC3_MOUSE
θ value	1.74796e-11 (rank : 132)	NC score	0.653714 (rank : 119)
Query Neighborhood Hits	524	Target Neighborhood Hits	207	Shared Neighborhood Hits	159
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FGFR1_MOUSE
θ value	2.28291e-11 (rank : 133)	NC score	0.353915 (rank : 237)
Query Neighborhood Hits	524	Target Neighborhood Hits	1068	Shared Neighborhood Hits	299
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGRL1_MOUSE
θ value	2.28291e-11 (rank : 134)	NC score	0.798389 (rank : 60)
Query Neighborhood Hits	524	Target Neighborhood Hits	325	Shared Neighborhood Hits	288
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

FSTL5_MOUSE
θ value	5.08577e-11 (rank : 135)	NC score	0.693477 (rank : 98)
Query Neighborhood Hits	524	Target Neighborhood Hits	355	Shared Neighborhood Hits	260
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

VGFR2_HUMAN
θ value	5.08577e-11 (rank : 136)	NC score	0.415078 (rank : 188)
Query Neighborhood Hits	524	Target Neighborhood Hits	1103	Shared Neighborhood Hits	334
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

CO7A1_HUMAN
θ value	1.133e-10 (rank : 137)	NC score	0.285183 (rank : 292)
Query Neighborhood Hits	524	Target Neighborhood Hits	807	Shared Neighborhood Hits	153
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

ATL3_HUMAN
θ value	1.47974e-10 (rank : 138)	NC score	0.464644 (rank : 171)
Query Neighborhood Hits	524	Target Neighborhood Hits	414	Shared Neighborhood Hits	272
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

FSTL5_HUMAN
θ value	1.9326e-10 (rank : 139)	NC score	0.698603 (rank : 92)
Query Neighborhood Hits	524	Target Neighborhood Hits	347	Shared Neighborhood Hits	266
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

UFO_HUMAN
θ value	1.9326e-10 (rank : 140)	NC score	0.296934 (rank : 280)
Query Neighborhood Hits	524	Target Neighborhood Hits	981	Shared Neighborhood Hits	248
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

FGFR4_MOUSE
θ value	2.52405e-10 (rank : 141)	NC score	0.368906 (rank : 223)
Query Neighborhood Hits	524	Target Neighborhood Hits	1026	Shared Neighborhood Hits	301
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

UFO_MOUSE
θ value	2.52405e-10 (rank : 142)	NC score	0.304052 (rank : 273)
Query Neighborhood Hits	524	Target Neighborhood Hits	988	Shared Neighborhood Hits	255
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

COCA1_HUMAN
θ value	4.30538e-10 (rank : 143)	NC score	0.392817 (rank : 205)
Query Neighborhood Hits	524	Target Neighborhood Hits	458	Shared Neighborhood Hits	155
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

TENA_HUMAN
θ value	7.34386e-10 (rank : 144)	NC score	0.251358 (rank : 327)
Query Neighborhood Hits	524	Target Neighborhood Hits	631	Shared Neighborhood Hits	150
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

COEA1_HUMAN
θ value	1.25267e-09 (rank : 145)	NC score	0.306216 (rank : 272)
Query Neighborhood Hits	524	Target Neighborhood Hits	427	Shared Neighborhood Hits	123
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

FGFR4_HUMAN
θ value	1.25267e-09 (rank : 146)	NC score	0.362450 (rank : 225)
Query Neighborhood Hits	524	Target Neighborhood Hits	1037	Shared Neighborhood Hits	301
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

LRRN1_HUMAN
θ value	1.25267e-09 (rank : 147)	NC score	0.361518 (rank : 226)
Query Neighborhood Hits	524	Target Neighborhood Hits	518	Shared Neighborhood Hits	262
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

COCA1_MOUSE
θ value	1.63604e-09 (rank : 148)	NC score	0.408834 (rank : 195)
Query Neighborhood Hits	524	Target Neighborhood Hits	467	Shared Neighborhood Hits	164
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

FGFR2_HUMAN
θ value	1.63604e-09 (rank : 149)	NC score	0.342273 (rank : 245)
Query Neighborhood Hits	524	Target Neighborhood Hits	1062	Shared Neighborhood Hits	286
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

LRRN1_MOUSE
θ value	1.63604e-09 (rank : 150)	NC score	0.350745 (rank : 239)
Query Neighborhood Hits	524	Target Neighborhood Hits	508	Shared Neighborhood Hits	258
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

VGFR3_HUMAN
θ value	2.79066e-09 (rank : 151)	NC score	0.355019 (rank : 234)
Query Neighborhood Hits	524	Target Neighborhood Hits	1037	Shared Neighborhood Hits	297
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

COKA1_HUMAN
θ value	3.64472e-09 (rank : 152)	NC score	0.289798 (rank : 287)
Query Neighborhood Hits	524	Target Neighborhood Hits	403	Shared Neighborhood Hits	115
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

MYOTI_HUMAN
θ value	3.64472e-09 (rank : 153)	NC score	0.797147 (rank : 61)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	265
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

PGFRA_MOUSE
θ value	3.64472e-09 (rank : 154)	NC score	0.287414 (rank : 290)
Query Neighborhood Hits	524	Target Neighborhood Hits	975	Shared Neighborhood Hits	242
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

MYOTI_MOUSE
θ value	4.76016e-09 (rank : 155)	NC score	0.797092 (rank : 62)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	259
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

JAM1_HUMAN
θ value	6.21693e-09 (rank : 156)	NC score	0.691051 (rank : 100)
Query Neighborhood Hits	524	Target Neighborhood Hits	294	Shared Neighborhood Hits	263
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

CEAM1_HUMAN
θ value	8.11959e-09 (rank : 157)	NC score	0.608834 (rank : 137)
Query Neighborhood Hits	524	Target Neighborhood Hits	348	Shared Neighborhood Hits	269
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

EPHA7_MOUSE
θ value	8.11959e-09 (rank : 158)	NC score	0.225829 (rank : 346)
Query Neighborhood Hits	524	Target Neighborhood Hits	1025	Shared Neighborhood Hits	181
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA7_HUMAN
θ value	1.06045e-08 (rank : 159)	NC score	0.227807 (rank : 345)
Query Neighborhood Hits	524	Target Neighborhood Hits	1053	Shared Neighborhood Hits	181
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

MYBPH_MOUSE
θ value	1.06045e-08 (rank : 160)	NC score	0.623590 (rank : 130)
Query Neighborhood Hits	524	Target Neighborhood Hits	290	Shared Neighborhood Hits	233
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

CD22_HUMAN
θ value	1.38499e-08 (rank : 161)	NC score	0.701867 (rank : 90)
Query Neighborhood Hits	524	Target Neighborhood Hits	365	Shared Neighborhood Hits	268
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

FGFR3_MOUSE
θ value	1.38499e-08 (rank : 162)	NC score	0.358692 (rank : 229)
Query Neighborhood Hits	524	Target Neighborhood Hits	1059	Shared Neighborhood Hits	301
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

IL6RB_HUMAN
θ value	1.38499e-08 (rank : 163)	NC score	0.439636 (rank : 179)
Query Neighborhood Hits	524	Target Neighborhood Hits	181	Shared Neighborhood Hits	131
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

VGFR3_MOUSE
θ value	1.38499e-08 (rank : 164)	NC score	0.355501 (rank : 233)
Query Neighborhood Hits	524	Target Neighborhood Hits	1056	Shared Neighborhood Hits	310
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

BASI_HUMAN
θ value	1.80886e-08 (rank : 165)	NC score	0.608870 (rank : 136)
Query Neighborhood Hits	524	Target Neighborhood Hits	211	Shared Neighborhood Hits	198
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

GPA33_MOUSE
θ value	1.80886e-08 (rank : 166)	NC score	0.555568 (rank : 149)
Query Neighborhood Hits	524	Target Neighborhood Hits	294	Shared Neighborhood Hits	219
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

SORL_MOUSE
θ value	1.80886e-08 (rank : 167)	NC score	0.250292 (rank : 328)
Query Neighborhood Hits	524	Target Neighborhood Hits	439	Shared Neighborhood Hits	126
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

MUC18_MOUSE
θ value	2.36244e-08 (rank : 168)	NC score	0.683174 (rank : 105)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	238
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

PSG10_HUMAN
θ value	2.36244e-08 (rank : 169)	NC score	0.450365 (rank : 177)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	208
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG6_HUMAN
θ value	2.36244e-08 (rank : 170)	NC score	0.453934 (rank : 176)
Query Neighborhood Hits	524	Target Neighborhood Hits	231	Shared Neighborhood Hits	210
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

PTPRT_HUMAN
θ value	2.36244e-08 (rank : 171)	NC score	0.312032 (rank : 269)
Query Neighborhood Hits	524	Target Neighborhood Hits	217	Shared Neighborhood Hits	131
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	2.36244e-08 (rank : 172)	NC score	0.313129 (rank : 267)
Query Neighborhood Hits	524	Target Neighborhood Hits	219	Shared Neighborhood Hits	133
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

CD22_MOUSE
θ value	4.0297e-08 (rank : 173)	NC score	0.710072 (rank : 85)
Query Neighborhood Hits	524	Target Neighborhood Hits	331	Shared Neighborhood Hits	253
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

PSG3_HUMAN
θ value	4.0297e-08 (rank : 174)	NC score	0.479688 (rank : 164)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	220
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

PVRL3_MOUSE
θ value	4.0297e-08 (rank : 175)	NC score	0.404377 (rank : 198)
Query Neighborhood Hits	524	Target Neighborhood Hits	212	Shared Neighborhood Hits	173
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

IGS4B_MOUSE
θ value	5.26297e-08 (rank : 176)	NC score	0.654921 (rank : 117)
Query Neighborhood Hits	524	Target Neighborhood Hits	328	Shared Neighborhood Hits	269
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

JAM1_MOUSE
θ value	5.26297e-08 (rank : 177)	NC score	0.663298 (rank : 111)
Query Neighborhood Hits	524	Target Neighborhood Hits	287	Shared Neighborhood Hits	256
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

LRFN2_HUMAN
θ value	5.26297e-08 (rank : 178)	NC score	0.406411 (rank : 196)
Query Neighborhood Hits	524	Target Neighborhood Hits	450	Shared Neighborhood Hits	220
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

PVRL3_HUMAN
θ value	5.26297e-08 (rank : 179)	NC score	0.389232 (rank : 210)
Query Neighborhood Hits	524	Target Neighborhood Hits	204	Shared Neighborhood Hits	166
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

TMIGD_HUMAN
θ value	5.26297e-08 (rank : 180)	NC score	0.693853 (rank : 96)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	221
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

KIT_MOUSE
θ value	6.87365e-08 (rank : 181)	NC score	0.278927 (rank : 300)
Query Neighborhood Hits	524	Target Neighborhood Hits	949	Shared Neighborhood Hits	225
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

FGFR2_MOUSE
θ value	8.97725e-08 (rank : 182)	NC score	0.331543 (rank : 254)
Query Neighborhood Hits	524	Target Neighborhood Hits	1062	Shared Neighborhood Hits	287
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

LU_HUMAN
θ value	8.97725e-08 (rank : 183)	NC score	0.720867 (rank : 77)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	257
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

FGFR3_HUMAN
θ value	1.17247e-07 (rank : 184)	NC score	0.347248 (rank : 241)
Query Neighborhood Hits	524	Target Neighborhood Hits	1042	Shared Neighborhood Hits	292
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

MYOM1_MOUSE
θ value	1.17247e-07 (rank : 185)	NC score	0.737469 (rank : 74)
Query Neighborhood Hits	524	Target Neighborhood Hits	415	Shared Neighborhood Hits	318
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

PVR_HUMAN
θ value	1.17247e-07 (rank : 186)	NC score	0.324398 (rank : 260)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	142
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

TENR_HUMAN
θ value	1.17247e-07 (rank : 187)	NC score	0.320369 (rank : 263)
Query Neighborhood Hits	524	Target Neighborhood Hits	526	Shared Neighborhood Hits	158
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

GPA33_HUMAN
θ value	1.53129e-07 (rank : 188)	NC score	0.527028 (rank : 158)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	215
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

I12R2_HUMAN
θ value	1.53129e-07 (rank : 189)	NC score	0.377506 (rank : 219)
Query Neighborhood Hits	524	Target Neighborhood Hits	163	Shared Neighborhood Hits	113
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

ICAM5_MOUSE
θ value	1.53129e-07 (rank : 190)	NC score	0.681239 (rank : 106)
Query Neighborhood Hits	524	Target Neighborhood Hits	308	Shared Neighborhood Hits	253
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

LRFN2_MOUSE
θ value	1.53129e-07 (rank : 191)	NC score	0.405642 (rank : 197)
Query Neighborhood Hits	524	Target Neighborhood Hits	450	Shared Neighborhood Hits	225
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

PSG9_HUMAN
θ value	1.53129e-07 (rank : 192)	NC score	0.436477 (rank : 181)
Query Neighborhood Hits	524	Target Neighborhood Hits	221	Shared Neighborhood Hits	203
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

CI094_HUMAN
θ value	1.99992e-07 (rank : 193)	NC score	0.577074 (rank : 146)
Query Neighborhood Hits	524	Target Neighborhood Hits	310	Shared Neighborhood Hits	235
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

MAG_MOUSE
θ value	1.99992e-07 (rank : 194)	NC score	0.713672 (rank : 83)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	249
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

TENA_MOUSE
θ value	1.99992e-07 (rank : 195)	NC score	0.235726 (rank : 340)
Query Neighborhood Hits	524	Target Neighborhood Hits	596	Shared Neighborhood Hits	141
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

BASI_MOUSE
θ value	2.61198e-07 (rank : 196)	NC score	0.598839 (rank : 139)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	208
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

LRFN5_HUMAN
θ value	3.41135e-07 (rank : 197)	NC score	0.376276 (rank : 220)
Query Neighborhood Hits	524	Target Neighborhood Hits	464	Shared Neighborhood Hits	225
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

CD276_HUMAN
θ value	4.45536e-07 (rank : 198)	NC score	0.437380 (rank : 180)
Query Neighborhood Hits	524	Target Neighborhood Hits	261	Shared Neighborhood Hits	183
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

EPHA2_MOUSE
θ value	5.81887e-07 (rank : 199)	NC score	0.196982 (rank : 376)
Query Neighborhood Hits	524	Target Neighborhood Hits	1020	Shared Neighborhood Hits	164
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

LIFR_HUMAN
θ value	5.81887e-07 (rank : 200)	NC score	0.392562 (rank : 207)
Query Neighborhood Hits	524	Target Neighborhood Hits	130	Shared Neighborhood Hits	95
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

MAG_HUMAN
θ value	5.81887e-07 (rank : 201)	NC score	0.712415 (rank : 84)
Query Neighborhood Hits	524	Target Neighborhood Hits	278	Shared Neighborhood Hits	252
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

PSG8_HUMAN
θ value	5.81887e-07 (rank : 202)	NC score	0.475381 (rank : 167)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	219
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PSG4_HUMAN
θ value	7.59969e-07 (rank : 203)	NC score	0.474595 (rank : 168)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	219
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

CEA20_HUMAN
θ value	9.92553e-07 (rank : 204)	NC score	0.632427 (rank : 127)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	213
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

IGS4B_HUMAN
θ value	9.92553e-07 (rank : 205)	NC score	0.642333 (rank : 123)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	257
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

LRFN4_HUMAN
θ value	9.92553e-07 (rank : 206)	NC score	0.414906 (rank : 189)
Query Neighborhood Hits	524	Target Neighborhood Hits	462	Shared Neighborhood Hits	224
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

NRG2_HUMAN
θ value	9.92553e-07 (rank : 207)	NC score	0.546891 (rank : 152)
Query Neighborhood Hits	524	Target Neighborhood Hits	419	Shared Neighborhood Hits	242
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

PSG11_HUMAN
θ value	9.92553e-07 (rank : 208)	NC score	0.458400 (rank : 173)
Query Neighborhood Hits	524	Target Neighborhood Hits	223	Shared Neighborhood Hits	211
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

TIE2_HUMAN
θ value	9.92553e-07 (rank : 209)	NC score	0.238662 (rank : 338)
Query Neighborhood Hits	524	Target Neighborhood Hits	1192	Shared Neighborhood Hits	195
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

IGF1R_HUMAN
θ value	1.29631e-06 (rank : 210)	NC score	0.190638 (rank : 385)
Query Neighborhood Hits	524	Target Neighborhood Hits	977	Shared Neighborhood Hits	141
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LRFN5_MOUSE
θ value	1.29631e-06 (rank : 211)	NC score	0.382682 (rank : 213)
Query Neighborhood Hits	524	Target Neighborhood Hits	472	Shared Neighborhood Hits	230
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

SIG10_HUMAN
θ value	1.29631e-06 (rank : 212)	NC score	0.579822 (rank : 144)
Query Neighborhood Hits	524	Target Neighborhood Hits	363	Shared Neighborhood Hits	237
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

I12R2_MOUSE
θ value	1.69304e-06 (rank : 213)	NC score	0.375901 (rank : 221)
Query Neighborhood Hits	524	Target Neighborhood Hits	143	Shared Neighborhood Hits	113
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

LRFN3_MOUSE
θ value	1.69304e-06 (rank : 214)	NC score	0.401683 (rank : 200)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

MALT1_HUMAN
θ value	1.69304e-06 (rank : 215)	NC score	0.700527 (rank : 91)
Query Neighborhood Hits	524	Target Neighborhood Hits	236	Shared Neighborhood Hits	215
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

NRG2_MOUSE
θ value	1.69304e-06 (rank : 216)	NC score	0.539124 (rank : 154)
Query Neighborhood Hits	524	Target Neighborhood Hits	392	Shared Neighborhood Hits	242
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

PSG2_HUMAN
θ value	1.69304e-06 (rank : 217)	NC score	0.449885 (rank : 178)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	213
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

TENN_MOUSE
θ value	1.69304e-06 (rank : 218)	NC score	0.323030 (rank : 262)
Query Neighborhood Hits	524	Target Neighborhood Hits	484	Shared Neighborhood Hits	151
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

LRRN3_MOUSE
θ value	2.21117e-06 (rank : 219)	NC score	0.342805 (rank : 243)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	224
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

LRRN5_HUMAN
θ value	2.21117e-06 (rank : 220)	NC score	0.338138 (rank : 252)
Query Neighborhood Hits	524	Target Neighborhood Hits	493	Shared Neighborhood Hits	240
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

PSG1_HUMAN
θ value	2.21117e-06 (rank : 221)	NC score	0.455816 (rank : 174)
Query Neighborhood Hits	524	Target Neighborhood Hits	232	Shared Neighborhood Hits	216
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

TIE2_MOUSE
θ value	2.21117e-06 (rank : 222)	NC score	0.240532 (rank : 336)
Query Neighborhood Hits	524	Target Neighborhood Hits	1204	Shared Neighborhood Hits	197
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

LRRN3_HUMAN
θ value	2.88788e-06 (rank : 223)	NC score	0.358505 (rank : 230)
Query Neighborhood Hits	524	Target Neighborhood Hits	461	Shared Neighborhood Hits	228
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

NPTN_HUMAN
θ value	2.88788e-06 (rank : 224)	NC score	0.651018 (rank : 120)
Query Neighborhood Hits	524	Target Neighborhood Hits	212	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

ROR1_HUMAN
θ value	2.88788e-06 (rank : 225)	NC score	0.279877 (rank : 299)
Query Neighborhood Hits	524	Target Neighborhood Hits	1018	Shared Neighborhood Hits	255
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	2.88788e-06 (rank : 226)	NC score	0.277812 (rank : 304)
Query Neighborhood Hits	524	Target Neighborhood Hits	1025	Shared Neighborhood Hits	258
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

TIE1_MOUSE
θ value	2.88788e-06 (rank : 227)	NC score	0.257716 (rank : 322)
Query Neighborhood Hits	524	Target Neighborhood Hits	1266	Shared Neighborhood Hits	227
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

LRFN3_HUMAN
θ value	3.77169e-06 (rank : 228)	NC score	0.382400 (rank : 214)
Query Neighborhood Hits	524	Target Neighborhood Hits	444	Shared Neighborhood Hits	213
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

IGF1R_MOUSE
θ value	4.92598e-06 (rank : 229)	NC score	0.189506 (rank : 386)
Query Neighborhood Hits	524	Target Neighborhood Hits	973	Shared Neighborhood Hits	140
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ROR2_MOUSE
θ value	4.92598e-06 (rank : 230)	NC score	0.301489 (rank : 276)
Query Neighborhood Hits	524	Target Neighborhood Hits	1000	Shared Neighborhood Hits	264
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

TENR_MOUSE
θ value	4.92598e-06 (rank : 231)	NC score	0.310288 (rank : 270)
Query Neighborhood Hits	524	Target Neighborhood Hits	531	Shared Neighborhood Hits	150
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

ICAM5_HUMAN
θ value	6.43352e-06 (rank : 232)	NC score	0.659348 (rank : 113)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	243
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

JAM3_MOUSE
θ value	8.40245e-06 (rank : 233)	NC score	0.667107 (rank : 110)
Query Neighborhood Hits	524	Target Neighborhood Hits	286	Shared Neighborhood Hits	250
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

SIG11_HUMAN
θ value	8.40245e-06 (rank : 234)	NC score	0.587043 (rank : 143)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	247
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

CD166_MOUSE
θ value	1.09739e-05 (rank : 235)	NC score	0.558549 (rank : 148)
Query Neighborhood Hits	524	Target Neighborhood Hits	252	Shared Neighborhood Hits	209
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

EPHA2_HUMAN
θ value	1.09739e-05 (rank : 236)	NC score	0.202242 (rank : 371)
Query Neighborhood Hits	524	Target Neighborhood Hits	1021	Shared Neighborhood Hits	170
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

PECA1_MOUSE
θ value	1.09739e-05 (rank : 237)	NC score	0.297163 (rank : 279)
Query Neighborhood Hits	524	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

PGFRA_HUMAN
θ value	1.09739e-05 (rank : 238)	NC score	0.287747 (rank : 289)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	241
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PTPRK_MOUSE
θ value	1.09739e-05 (rank : 239)	NC score	0.282199 (rank : 294)
Query Neighborhood Hits	524	Target Neighborhood Hits	223	Shared Neighborhood Hits	136
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

ROR2_HUMAN
θ value	1.43324e-05 (rank : 240)	NC score	0.290968 (rank : 285)
Query Neighborhood Hits	524	Target Neighborhood Hits	1014	Shared Neighborhood Hits	260
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

PSG5_HUMAN
θ value	1.87187e-05 (rank : 241)	NC score	0.426838 (rank : 185)
Query Neighborhood Hits	524	Target Neighborhood Hits	231	Shared Neighborhood Hits	208
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

TIE1_HUMAN
θ value	1.87187e-05 (rank : 242)	NC score	0.249537 (rank : 330)
Query Neighborhood Hits	524	Target Neighborhood Hits	1241	Shared Neighborhood Hits	214
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

VSIG2_MOUSE
θ value	1.87187e-05 (rank : 243)	NC score	0.607668 (rank : 138)
Query Neighborhood Hits	524	Target Neighborhood Hits	316	Shared Neighborhood Hits	244
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

CD166_HUMAN
θ value	2.44474e-05 (rank : 244)	NC score	0.531929 (rank : 156)
Query Neighborhood Hits	524	Target Neighborhood Hits	247	Shared Neighborhood Hits	200
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

CEAM6_HUMAN
θ value	2.44474e-05 (rank : 245)	NC score	0.548555 (rank : 151)
Query Neighborhood Hits	524	Target Neighborhood Hits	308	Shared Neighborhood Hits	263
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

EPHA3_MOUSE
θ value	2.44474e-05 (rank : 246)	NC score	0.220653 (rank : 353)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	188
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

KAZD1_MOUSE
θ value	2.44474e-05 (rank : 247)	NC score	0.578942 (rank : 145)
Query Neighborhood Hits	524	Target Neighborhood Hits	281	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

NTRK2_HUMAN
θ value	2.44474e-05 (rank : 248)	NC score	0.291986 (rank : 283)
Query Neighborhood Hits	524	Target Neighborhood Hits	1081	Shared Neighborhood Hits	261
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

TENX_HUMAN
θ value	2.44474e-05 (rank : 249)	NC score	0.245404 (rank : 333)
Query Neighborhood Hits	524	Target Neighborhood Hits	789	Shared Neighborhood Hits	155
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

VSIG2_HUMAN
θ value	2.44474e-05 (rank : 250)	NC score	0.622862 (rank : 131)
Query Neighborhood Hits	524	Target Neighborhood Hits	321	Shared Neighborhood Hits	253
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

PTPRK_HUMAN
θ value	3.19293e-05 (rank : 251)	NC score	0.278249 (rank : 303)
Query Neighborhood Hits	524	Target Neighborhood Hits	228	Shared Neighborhood Hits	137
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

LRFN4_MOUSE
θ value	4.1701e-05 (rank : 252)	NC score	0.408938 (rank : 194)
Query Neighborhood Hits	524	Target Neighborhood Hits	442	Shared Neighborhood Hits	217
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

PGFRB_HUMAN
θ value	4.1701e-05 (rank : 253)	NC score	0.271695 (rank : 310)
Query Neighborhood Hits	524	Target Neighborhood Hits	962	Shared Neighborhood Hits	231
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

CXAR_HUMAN
θ value	5.44631e-05 (rank : 254)	NC score	0.434447 (rank : 183)
Query Neighborhood Hits	524	Target Neighborhood Hits	245	Shared Neighborhood Hits	187
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

LIFR_MOUSE
θ value	5.44631e-05 (rank : 255)	NC score	0.379095 (rank : 217)
Query Neighborhood Hits	524	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

NTRK3_HUMAN
θ value	5.44631e-05 (rank : 256)	NC score	0.293144 (rank : 282)
Query Neighborhood Hits	524	Target Neighborhood Hits	1115	Shared Neighborhood Hits	258
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PSG7_HUMAN
θ value	5.44631e-05 (rank : 257)	NC score	0.460389 (rank : 172)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	218
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

TRIO_HUMAN
θ value	5.44631e-05 (rank : 258)	NC score	0.193816 (rank : 381)
Query Neighborhood Hits	524	Target Neighborhood Hits	1580	Shared Neighborhood Hits	283
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

IL1R1_MOUSE
θ value	7.1131e-05 (rank : 259)	NC score	0.289522 (rank : 288)
Query Neighborhood Hits	524	Target Neighborhood Hits	142	Shared Neighborhood Hits	127
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

PTPRJ_HUMAN
θ value	7.1131e-05 (rank : 260)	NC score	0.179367 (rank : 400)
Query Neighborhood Hits	524	Target Neighborhood Hits	207	Shared Neighborhood Hits	95
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

CSF1R_MOUSE
θ value	9.29e-05 (rank : 261)	NC score	0.317977 (rank : 264)
Query Neighborhood Hits	524	Target Neighborhood Hits	983	Shared Neighborhood Hits	252
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

MYBPH_HUMAN
θ value	9.29e-05 (rank : 262)	NC score	0.610038 (rank : 135)
Query Neighborhood Hits	524	Target Neighborhood Hits	256	Shared Neighborhood Hits	226
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

RAGE_MOUSE
θ value	9.29e-05 (rank : 263)	NC score	0.657858 (rank : 114)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	226
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

CSF3R_MOUSE
θ value	0.000121331 (rank : 264)	NC score	0.262999 (rank : 320)
Query Neighborhood Hits	524	Target Neighborhood Hits	104	Shared Neighborhood Hits	86
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

EMB_MOUSE
θ value	0.000121331 (rank : 265)	NC score	0.315130 (rank : 265)
Query Neighborhood Hits	524	Target Neighborhood Hits	83	Shared Neighborhood Hits	81
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

INSRR_HUMAN
θ value	0.000121331 (rank : 266)	NC score	0.195872 (rank : 377)
Query Neighborhood Hits	524	Target Neighborhood Hits	950	Shared Neighborhood Hits	138
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	0.000121331 (rank : 267)	NC score	0.195509 (rank : 378)
Query Neighborhood Hits	524	Target Neighborhood Hits	961	Shared Neighborhood Hits	138
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KAZD1_HUMAN
θ value	0.000121331 (rank : 268)	NC score	0.533831 (rank : 155)
Query Neighborhood Hits	524	Target Neighborhood Hits	248	Shared Neighborhood Hits	172
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

NTRK2_MOUSE
θ value	0.000121331 (rank : 269)	NC score	0.291441 (rank : 284)
Query Neighborhood Hits	524	Target Neighborhood Hits	1088	Shared Neighborhood Hits	261
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

CEAM7_HUMAN
θ value	0.000158464 (rank : 270)	NC score	0.338508 (rank : 251)
Query Neighborhood Hits	524	Target Neighborhood Hits	170	Shared Neighborhood Hits	147
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

CILP1_MOUSE
θ value	0.000158464 (rank : 271)	NC score	0.354158 (rank : 236)
Query Neighborhood Hits	524	Target Neighborhood Hits	282	Shared Neighborhood Hits	193
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

KIT_HUMAN
θ value	0.000158464 (rank : 272)	NC score	0.264018 (rank : 318)
Query Neighborhood Hits	524	Target Neighborhood Hits	953	Shared Neighborhood Hits	218
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

EPHA8_HUMAN
θ value	0.00020696 (rank : 273)	NC score	0.221783 (rank : 351)
Query Neighborhood Hits	524	Target Neighborhood Hits	956	Shared Neighborhood Hits	183
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHB3_MOUSE
θ value	0.00020696 (rank : 274)	NC score	0.223781 (rank : 349)
Query Neighborhood Hits	524	Target Neighborhood Hits	996	Shared Neighborhood Hits	184
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_MOUSE
θ value	0.00020696 (rank : 275)	NC score	0.215945 (rank : 358)
Query Neighborhood Hits	524	Target Neighborhood Hits	1013	Shared Neighborhood Hits	182
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

FCRL2_HUMAN
θ value	0.00020696 (rank : 276)	NC score	0.590020 (rank : 141)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	208
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

IL6RA_HUMAN
θ value	0.00020696 (rank : 277)	NC score	0.142137 (rank : 436)
Query Neighborhood Hits	524	Target Neighborhood Hits	96	Shared Neighborhood Hits	62
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

LRRC4_HUMAN
θ value	0.00020696 (rank : 278)	NC score	0.249559 (rank : 329)
Query Neighborhood Hits	524	Target Neighborhood Hits	444	Shared Neighborhood Hits	196
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

EPHA8_MOUSE
θ value	0.000270298 (rank : 279)	NC score	0.224564 (rank : 348)
Query Neighborhood Hits	524	Target Neighborhood Hits	969	Shared Neighborhood Hits	186
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

IL1R1_HUMAN
θ value	0.000270298 (rank : 280)	NC score	0.307261 (rank : 271)
Query Neighborhood Hits	524	Target Neighborhood Hits	140	Shared Neighborhood Hits	126
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

JAM2_MOUSE
θ value	0.000270298 (rank : 281)	NC score	0.630518 (rank : 128)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	262
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

CSF1R_HUMAN
θ value	0.00035302 (rank : 282)	NC score	0.266785 (rank : 313)
Query Neighborhood Hits	524	Target Neighborhood Hits	943	Shared Neighborhood Hits	214
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

JAM3_HUMAN
θ value	0.00035302 (rank : 283)	NC score	0.660889 (rank : 112)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	243
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

LRC4B_HUMAN
θ value	0.00035302 (rank : 284)	NC score	0.275983 (rank : 306)
Query Neighborhood Hits	524	Target Neighborhood Hits	479	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC4B_MOUSE
θ value	0.00035302 (rank : 285)	NC score	0.278606 (rank : 302)
Query Neighborhood Hits	524	Target Neighborhood Hits	484	Shared Neighborhood Hits	216
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

NGL1_HUMAN
θ value	0.00035302 (rank : 286)	NC score	0.281323 (rank : 297)
Query Neighborhood Hits	524	Target Neighborhood Hits	511	Shared Neighborhood Hits	227
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_MOUSE
θ value	0.00035302 (rank : 287)	NC score	0.281687 (rank : 296)
Query Neighborhood Hits	524	Target Neighborhood Hits	512	Shared Neighborhood Hits	227
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

CEAM8_HUMAN
θ value	0.000461057 (rank : 288)	NC score	0.489491 (rank : 162)
Query Neighborhood Hits	524	Target Neighborhood Hits	264	Shared Neighborhood Hits	233
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

EPHB3_HUMAN
θ value	0.000461057 (rank : 289)	NC score	0.222271 (rank : 350)
Query Neighborhood Hits	524	Target Neighborhood Hits	996	Shared Neighborhood Hits	184
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

INSR_MOUSE
θ value	0.000461057 (rank : 290)	NC score	0.187954 (rank : 388)
Query Neighborhood Hits	524	Target Neighborhood Hits	968	Shared Neighborhood Hits	138
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

CD276_MOUSE
θ value	0.000602161 (rank : 291)	NC score	0.359858 (rank : 227)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	182
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

EPHB2_HUMAN
θ value	0.000602161 (rank : 292)	NC score	0.203132 (rank : 369)
Query Neighborhood Hits	524	Target Neighborhood Hits	983	Shared Neighborhood Hits	170
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

PVRL1_HUMAN
θ value	0.000602161 (rank : 293)	NC score	0.371336 (rank : 222)
Query Neighborhood Hits	524	Target Neighborhood Hits	219	Shared Neighborhood Hits	167
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

EPHB2_MOUSE
θ value	0.000786445 (rank : 294)	NC score	0.203143 (rank : 368)
Query Neighborhood Hits	524	Target Neighborhood Hits	982	Shared Neighborhood Hits	170
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB4_HUMAN
θ value	0.000786445 (rank : 295)	NC score	0.210196 (rank : 361)
Query Neighborhood Hits	524	Target Neighborhood Hits	1056	Shared Neighborhood Hits	185
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

FCG2A_HUMAN
θ value	0.000786445 (rank : 296)	NC score	0.157331 (rank : 416)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	72
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

IL6RB_MOUSE
θ value	0.000786445 (rank : 297)	NC score	0.392804 (rank : 206)
Query Neighborhood Hits	524	Target Neighborhood Hits	168	Shared Neighborhood Hits	128
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

LRC24_HUMAN
θ value	0.000786445 (rank : 298)	NC score	0.298360 (rank : 278)
Query Neighborhood Hits	524	Target Neighborhood Hits	404	Shared Neighborhood Hits	195
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

EPHB6_HUMAN
θ value	0.00102713 (rank : 299)	NC score	0.236340 (rank : 339)
Query Neighborhood Hits	524	Target Neighborhood Hits	912	Shared Neighborhood Hits	178
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

FLT3_MOUSE
θ value	0.00102713 (rank : 300)	NC score	0.205419 (rank : 366)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	137
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

MFA3L_HUMAN
θ value	0.00102713 (rank : 301)	NC score	0.552865 (rank : 150)
Query Neighborhood Hits	524	Target Neighborhood Hits	230	Shared Neighborhood Hits	209
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

MFA3L_MOUSE
θ value	0.00102713 (rank : 302)	NC score	0.479083 (rank : 166)
Query Neighborhood Hits	524	Target Neighborhood Hits	214	Shared Neighborhood Hits	192
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

NPTN_MOUSE
θ value	0.00102713 (rank : 303)	NC score	0.638970 (rank : 124)
Query Neighborhood Hits	524	Target Neighborhood Hits	216	Shared Neighborhood Hits	206
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

RAGE_HUMAN
θ value	0.00102713 (rank : 304)	NC score	0.693256 (rank : 99)
Query Neighborhood Hits	524	Target Neighborhood Hits	269	Shared Neighborhood Hits	245
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

VSIG4_HUMAN
θ value	0.00102713 (rank : 305)	NC score	0.546402 (rank : 153)
Query Neighborhood Hits	524	Target Neighborhood Hits	236	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

IBP7_HUMAN
θ value	0.00134147 (rank : 306)	NC score	0.504093 (rank : 161)
Query Neighborhood Hits	524	Target Neighborhood Hits	220	Shared Neighborhood Hits	165
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

LRC21_MOUSE
θ value	0.00134147 (rank : 307)	NC score	0.381874 (rank : 215)
Query Neighborhood Hits	524	Target Neighborhood Hits	462	Shared Neighborhood Hits	237
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

EMB_HUMAN
θ value	0.00175202 (rank : 308)	NC score	0.201880 (rank : 372)
Query Neighborhood Hits	524	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

INSR_HUMAN
θ value	0.00175202 (rank : 309)	NC score	0.183503 (rank : 392)
Query Neighborhood Hits	524	Target Neighborhood Hits	963	Shared Neighborhood Hits	135
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

JAM2_HUMAN
θ value	0.00175202 (rank : 310)	NC score	0.647132 (rank : 122)
Query Neighborhood Hits	524	Target Neighborhood Hits	304	Shared Neighborhood Hits	275
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

PVRL1_MOUSE
θ value	0.00175202 (rank : 311)	NC score	0.355559 (rank : 232)
Query Neighborhood Hits	524	Target Neighborhood Hits	201	Shared Neighborhood Hits	158
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

ROS_HUMAN
θ value	0.00175202 (rank : 312)	NC score	0.229972 (rank : 343)
Query Neighborhood Hits	524	Target Neighborhood Hits	907	Shared Neighborhood Hits	181
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

IBP7_MOUSE
θ value	0.00228821 (rank : 313)	NC score	0.487492 (rank : 163)
Query Neighborhood Hits	524	Target Neighborhood Hits	230	Shared Neighborhood Hits	162
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IL1R2_MOUSE
θ value	0.00228821 (rank : 314)	NC score	0.341569 (rank : 247)
Query Neighborhood Hits	524	Target Neighborhood Hits	125	Shared Neighborhood Hits	108
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

CXAR_MOUSE
θ value	0.00298849 (rank : 315)	NC score	0.413089 (rank : 190)
Query Neighborhood Hits	524	Target Neighborhood Hits	250	Shared Neighborhood Hits	190
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

EPHA3_HUMAN
θ value	0.00298849 (rank : 316)	NC score	0.217109 (rank : 356)
Query Neighborhood Hits	524	Target Neighborhood Hits	1005	Shared Neighborhood Hits	187
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHB1_HUMAN
θ value	0.00298849 (rank : 317)	NC score	0.203925 (rank : 367)
Query Neighborhood Hits	524	Target Neighborhood Hits	988	Shared Neighborhood Hits	174
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB6_MOUSE
θ value	0.00298849 (rank : 318)	NC score	0.229919 (rank : 344)
Query Neighborhood Hits	524	Target Neighborhood Hits	906	Shared Neighborhood Hits	170
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

IRPL2_HUMAN
θ value	0.00298849 (rank : 319)	NC score	0.342571 (rank : 244)
Query Neighborhood Hits	524	Target Neighborhood Hits	194	Shared Neighborhood Hits	155
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

PECA1_HUMAN
θ value	0.00298849 (rank : 320)	NC score	0.383117 (rank : 212)
Query Neighborhood Hits	524	Target Neighborhood Hits	178	Shared Neighborhood Hits	151
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

EPN2_HUMAN
θ value	0.00390308 (rank : 321)	NC score	0.023770 (rank : 1191)
Query Neighborhood Hits	524	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

IRPL2_MOUSE
θ value	0.00390308 (rank : 322)	NC score	0.339061 (rank : 249)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	154
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

LRC21_HUMAN
θ value	0.00390308 (rank : 323)	NC score	0.378518 (rank : 218)
Query Neighborhood Hits	524	Target Neighborhood Hits	456	Shared Neighborhood Hits	237
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

CILP1_HUMAN
θ value	0.00665767 (rank : 324)	NC score	0.328171 (rank : 258)
Query Neighborhood Hits	524	Target Neighborhood Hits	266	Shared Neighborhood Hits	173
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

PGFRB_MOUSE
θ value	0.00665767 (rank : 325)	NC score	0.280903 (rank : 298)
Query Neighborhood Hits	524	Target Neighborhood Hits	960	Shared Neighborhood Hits	225
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

TENN_HUMAN
θ value	0.00665767 (rank : 326)	NC score	0.282154 (rank : 295)
Query Neighborhood Hits	524	Target Neighborhood Hits	453	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

IRPL1_MOUSE
θ value	0.00869519 (rank : 327)	NC score	0.338642 (rank : 250)
Query Neighborhood Hits	524	Target Neighborhood Hits	186	Shared Neighborhood Hits	163
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

CT075_MOUSE
θ value	0.0113563 (rank : 328)	NC score	0.164968 (rank : 410)
Query Neighborhood Hits	524	Target Neighborhood Hits	358	Shared Neighborhood Hits	100
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

EPHA5_MOUSE
θ value	0.0113563 (rank : 329)	NC score	0.191012 (rank : 384)
Query Neighborhood Hits	524	Target Neighborhood Hits	950	Shared Neighborhood Hits	169
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

FCG2B_HUMAN
θ value	0.0113563 (rank : 330)	NC score	0.181517 (rank : 396)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	82
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

FCG2C_HUMAN
θ value	0.0113563 (rank : 331)	NC score	0.181184 (rank : 398)
Query Neighborhood Hits	524	Target Neighborhood Hits	118	Shared Neighborhood Hits	83
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

JAML1_MOUSE
θ value	0.0113563 (rank : 332)	NC score	0.259538 (rank : 321)
Query Neighborhood Hits	524	Target Neighborhood Hits	185	Shared Neighborhood Hits	135
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

UNC5A_HUMAN
θ value	0.0113563 (rank : 333)	NC score	0.271148 (rank : 311)
Query Neighborhood Hits	524	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5A_MOUSE
θ value	0.0113563 (rank : 334)	NC score	0.240822 (rank : 335)
Query Neighborhood Hits	524	Target Neighborhood Hits	203	Shared Neighborhood Hits	120
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

AMGO2_HUMAN
θ value	0.0148317 (rank : 335)	NC score	0.156152 (rank : 419)
Query Neighborhood Hits	524	Target Neighborhood Hits	357	Shared Neighborhood Hits	133
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

LRC24_MOUSE
θ value	0.0148317 (rank : 336)	NC score	0.274901 (rank : 307)
Query Neighborhood Hits	524	Target Neighborhood Hits	387	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

PVRL2_HUMAN
θ value	0.0148317 (rank : 337)	NC score	0.286774 (rank : 291)
Query Neighborhood Hits	524	Target Neighborhood Hits	185	Shared Neighborhood Hits	131
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

CD48_MOUSE
θ value	0.0193708 (rank : 338)	NC score	0.136950 (rank : 446)
Query Neighborhood Hits	524	Target Neighborhood Hits	96	Shared Neighborhood Hits	64
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

IL6RA_MOUSE
θ value	0.0193708 (rank : 339)	NC score	0.168354 (rank : 407)
Query Neighborhood Hits	524	Target Neighborhood Hits	104	Shared Neighborhood Hits	81
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

IRPL1_HUMAN
θ value	0.0193708 (rank : 340)	NC score	0.330472 (rank : 255)
Query Neighborhood Hits	524	Target Neighborhood Hits	196	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

SIGL5_HUMAN
θ value	0.0193708 (rank : 341)	NC score	0.390705 (rank : 209)
Query Neighborhood Hits	524	Target Neighborhood Hits	246	Shared Neighborhood Hits	199
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

GP116_HUMAN
θ value	0.0252991 (rank : 342)	NC score	0.103563 (rank : 557)
Query Neighborhood Hits	524	Target Neighborhood Hits	167	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

IL1R2_HUMAN
θ value	0.0252991 (rank : 343)	NC score	0.410118 (rank : 193)
Query Neighborhood Hits	524	Target Neighborhood Hits	153	Shared Neighborhood Hits	141
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

IL27B_MOUSE
θ value	0.0252991 (rank : 344)	NC score	0.113960 (rank : 502)
Query Neighborhood Hits	524	Target Neighborhood Hits	55	Shared Neighborhood Hits	40
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

CILP2_HUMAN
θ value	0.0330416 (rank : 345)	NC score	0.396611 (rank : 203)
Query Neighborhood Hits	524	Target Neighborhood Hits	307	Shared Neighborhood Hits	194
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

ESAM_HUMAN
θ value	0.0330416 (rank : 346)	NC score	0.455538 (rank : 175)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	191
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

ESAM_MOUSE
θ value	0.0330416 (rank : 347)	NC score	0.410527 (rank : 191)
Query Neighborhood Hits	524	Target Neighborhood Hits	222	Shared Neighborhood Hits	183
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

ILRL1_HUMAN
θ value	0.0330416 (rank : 348)	NC score	0.266343 (rank : 314)
Query Neighborhood Hits	524	Target Neighborhood Hits	167	Shared Neighborhood Hits	133
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

PDL1_HUMAN
θ value	0.0330416 (rank : 349)	NC score	0.330328 (rank : 256)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PGFRL_MOUSE
θ value	0.0330416 (rank : 350)	NC score	0.271881 (rank : 309)
Query Neighborhood Hits	524	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

ILRL2_MOUSE
θ value	0.0431538 (rank : 351)	NC score	0.293398 (rank : 281)
Query Neighborhood Hits	524	Target Neighborhood Hits	158	Shared Neighborhood Hits	147
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

MOX2R_MOUSE
θ value	0.0431538 (rank : 352)	NC score	0.325045 (rank : 259)
Query Neighborhood Hits	524	Target Neighborhood Hits	110	Shared Neighborhood Hits	103
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

CNTFR_MOUSE
θ value	0.0563607 (rank : 353)	NC score	0.096776 (rank : 566)
Query Neighborhood Hits	524	Target Neighborhood Hits	74	Shared Neighborhood Hits	49
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CT075_HUMAN
θ value	0.0563607 (rank : 354)	NC score	0.198969 (rank : 374)
Query Neighborhood Hits	524	Target Neighborhood Hits	387	Shared Neighborhood Hits	115
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

EPHA4_HUMAN
θ value	0.0563607 (rank : 355)	NC score	0.216211 (rank : 357)
Query Neighborhood Hits	524	Target Neighborhood Hits	975	Shared Neighborhood Hits	178
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

NTRK1_HUMAN
θ value	0.0563607 (rank : 356)	NC score	0.201168 (rank : 373)
Query Neighborhood Hits	524	Target Neighborhood Hits	1023	Shared Neighborhood Hits	194
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

SIGL5_MOUSE
θ value	0.0563607 (rank : 357)	NC score	0.479643 (rank : 165)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	241
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

AMGO2_MOUSE
θ value	0.0736092 (rank : 358)	NC score	0.131805 (rank : 455)
Query Neighborhood Hits	524	Target Neighborhood Hits	329	Shared Neighborhood Hits	106
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

BT1A1_HUMAN
θ value	0.0736092 (rank : 359)	NC score	0.109534 (rank : 535)
Query Neighborhood Hits	524	Target Neighborhood Hits	322	Shared Neighborhood Hits	128
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

EPHA4_MOUSE
θ value	0.0736092 (rank : 360)	NC score	0.218762 (rank : 354)
Query Neighborhood Hits	524	Target Neighborhood Hits	982	Shared Neighborhood Hits	181
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

LEPR_MOUSE
θ value	0.0736092 (rank : 361)	NC score	0.117231 (rank : 496)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	66
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

UNC5D_HUMAN
θ value	0.0736092 (rank : 362)	NC score	0.329370 (rank : 257)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	184
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	0.0736092 (rank : 363)	NC score	0.335080 (rank : 253)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	186
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

I18RA_HUMAN
θ value	0.0961366 (rank : 364)	NC score	0.113377 (rank : 504)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	68
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

LRRC4_MOUSE
θ value	0.0961366 (rank : 365)	NC score	0.217162 (rank : 355)
Query Neighborhood Hits	524	Target Neighborhood Hits	412	Shared Neighborhood Hits	170
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

EPHA5_HUMAN
θ value	0.163984 (rank : 366)	NC score	0.207860 (rank : 365)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	182
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

HHLA2_HUMAN
θ value	0.163984 (rank : 367)	NC score	0.239741 (rank : 337)
Query Neighborhood Hits	524	Target Neighborhood Hits	140	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

PTPRB_HUMAN
θ value	0.163984 (rank : 368)	NC score	0.208517 (rank : 364)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	105
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

SHPS1_MOUSE
θ value	0.163984 (rank : 369)	NC score	0.130417 (rank : 457)
Query Neighborhood Hits	524	Target Neighborhood Hits	439	Shared Neighborhood Hits	129
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

BTNL2_HUMAN
θ value	0.21417 (rank : 370)	NC score	0.170001 (rank : 405)
Query Neighborhood Hits	524	Target Neighborhood Hits	164	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

CD45_MOUSE
θ value	0.21417 (rank : 371)	NC score	0.128658 (rank : 459)
Query Neighborhood Hits	524	Target Neighborhood Hits	178	Shared Neighborhood Hits	50
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

I11RB_MOUSE
θ value	0.21417 (rank : 372)	NC score	0.162924 (rank : 413)
Query Neighborhood Hits	524	Target Neighborhood Hits	101	Shared Neighborhood Hits	70
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

IL27B_HUMAN
θ value	0.21417 (rank : 373)	NC score	0.187701 (rank : 389)
Query Neighborhood Hits	524	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

ILRL2_HUMAN
θ value	0.21417 (rank : 374)	NC score	0.194857 (rank : 379)
Query Neighborhood Hits	524	Target Neighborhood Hits	112	Shared Neighborhood Hits	99
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

LY9_MOUSE
θ value	0.21417 (rank : 375)	NC score	0.145006 (rank : 430)
Query Neighborhood Hits	524	Target Neighborhood Hits	110	Shared Neighborhood Hits	76
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

PTPRJ_MOUSE
θ value	0.21417 (rank : 376)	NC score	0.181371 (rank : 397)
Query Neighborhood Hits	524	Target Neighborhood Hits	188	Shared Neighborhood Hits	91
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

BT2A3_HUMAN
θ value	0.279714 (rank : 377)	NC score	0.049024 (rank : 1173)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	72
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

EPHAA_HUMAN
θ value	0.279714 (rank : 378)	NC score	0.186670 (rank : 390)
Query Neighborhood Hits	524	Target Neighborhood Hits	960	Shared Neighborhood Hits	151
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

JAML1_HUMAN
θ value	0.279714 (rank : 379)	NC score	0.150930 (rank : 424)
Query Neighborhood Hits	524	Target Neighborhood Hits	108	Shared Neighborhood Hits	75
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

LEPR_HUMAN
θ value	0.279714 (rank : 380)	NC score	0.115959 (rank : 499)
Query Neighborhood Hits	524	Target Neighborhood Hits	112	Shared Neighborhood Hits	67
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

NSF1C_HUMAN
θ value	0.279714 (rank : 381)	NC score	0.019872 (rank : 1194)
Query Neighborhood Hits	524	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNZ2, Q7Z533, Q9H102, Q9NVL9, Q9UI06	Gene names	NSFL1C
Domain Architecture
Description	NSFL1 cofactor p47 (p97 cofactor p47).

PGFRL_HUMAN
θ value	0.279714 (rank : 382)	NC score	0.312782 (rank : 268)
Query Neighborhood Hits	524	Target Neighborhood Hits	115	Shared Neighborhood Hits	113
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PIGR_MOUSE
θ value	0.279714 (rank : 383)	NC score	0.302808 (rank : 275)
Query Neighborhood Hits	524	Target Neighborhood Hits	214	Shared Neighborhood Hits	151
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

PTPRV_MOUSE
θ value	0.279714 (rank : 384)	NC score	0.181717 (rank : 395)
Query Neighborhood Hits	524	Target Neighborhood Hits	179	Shared Neighborhood Hits	81
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

CD83_HUMAN
θ value	0.365318 (rank : 385)	NC score	0.059600 (rank : 870)
Query Neighborhood Hits	524	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q01151	Gene names	CD83
Domain Architecture
Description	CD83 antigen precursor (Cell surface protein HB15) (B-cell activation protein).

EPN2_MOUSE
θ value	0.365318 (rank : 386)	NC score	0.017452 (rank : 1197)
Query Neighborhood Hits	524	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHU3, O70447, Q8BZ85	Gene names	Epn2
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2) (Intersectin-EH-binding protein 2) (Ibp2).

I11RA_MOUSE
θ value	0.365318 (rank : 387)	NC score	0.152107 (rank : 421)
Query Neighborhood Hits	524	Target Neighborhood Hits	95	Shared Neighborhood Hits	65
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

ICAM3_HUMAN
θ value	0.365318 (rank : 388)	NC score	0.166365 (rank : 408)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

IL1AP_HUMAN
θ value	0.365318 (rank : 389)	NC score	0.094011 (rank : 576)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

TARA_HUMAN
θ value	0.365318 (rank : 390)	NC score	0.011144 (rank : 1211)
Query Neighborhood Hits	524	Target Neighborhood Hits	1626	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

BT1A1_MOUSE
θ value	0.47712 (rank : 391)	NC score	0.117334 (rank : 493)
Query Neighborhood Hits	524	Target Neighborhood Hits	252	Shared Neighborhood Hits	131
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT3A1_HUMAN
θ value	0.47712 (rank : 392)	NC score	0.083178 (rank : 620)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	107
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

CD226_HUMAN
θ value	0.47712 (rank : 393)	NC score	0.136833 (rank : 447)
Query Neighborhood Hits	524	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

CNTFR_HUMAN
θ value	0.47712 (rank : 394)	NC score	0.090575 (rank : 588)
Query Neighborhood Hits	524	Target Neighborhood Hits	66	Shared Neighborhood Hits	42
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

FCAR_HUMAN
θ value	0.47712 (rank : 395)	NC score	0.018888 (rank : 1195)
Query Neighborhood Hits	524	Target Neighborhood Hits	52	Shared Neighborhood Hits	15
SwissProt Accessions	P24071, Q13603, Q13604, Q15727, Q15728, Q92590	Gene names	FCAR, CD89
Domain Architecture	No domain graphic available
Description	Immunoglobulin alpha Fc receptor precursor (IgA Fc receptor) (CD89 antigen).

NRG1_HUMAN
θ value	0.47712 (rank : 396)	NC score	0.386340 (rank : 211)
Query Neighborhood Hits	524	Target Neighborhood Hits	285	Shared Neighborhood Hits	164
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

AMGO3_MOUSE
θ value	0.62314 (rank : 397)	NC score	0.119878 (rank : 486)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

BT3A2_HUMAN
θ value	0.62314 (rank : 398)	NC score	0.139028 (rank : 441)
Query Neighborhood Hits	524	Target Neighborhood Hits	158	Shared Neighborhood Hits	107
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

CD244_HUMAN
θ value	0.62314 (rank : 399)	NC score	0.110732 (rank : 525)
Query Neighborhood Hits	524	Target Neighborhood Hits	72	Shared Neighborhood Hits	45
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

FCGR1_HUMAN
θ value	0.62314 (rank : 400)	NC score	0.231273 (rank : 342)
Query Neighborhood Hits	524	Target Neighborhood Hits	145	Shared Neighborhood Hits	108
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

CD80_MOUSE
θ value	0.813845 (rank : 401)	NC score	0.225230 (rank : 347)
Query Neighborhood Hits	524	Target Neighborhood Hits	136	Shared Neighborhood Hits	112
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

MOX2R_HUMAN
θ value	0.813845 (rank : 402)	NC score	0.169048 (rank : 406)
Query Neighborhood Hits	524	Target Neighborhood Hits	51	Shared Neighborhood Hits	49
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

NSF1C_MOUSE
θ value	0.813845 (rank : 403)	NC score	0.017846 (rank : 1196)
Query Neighborhood Hits	524	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZ44, Q80Y15, Q8BYL3	Gene names	Nsfl1c
Domain Architecture
Description	NSFL1 cofactor p47 (p97 cofactor p47).

TPSNR_MOUSE
θ value	0.813845 (rank : 404)	NC score	0.159221 (rank : 414)
Query Neighborhood Hits	524	Target Neighborhood Hits	336	Shared Neighborhood Hits	118
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

AMGO1_HUMAN
θ value	1.06291 (rank : 405)	NC score	0.120707 (rank : 484)
Query Neighborhood Hits	524	Target Neighborhood Hits	353	Shared Neighborhood Hits	111
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

BT3A3_HUMAN
θ value	1.06291 (rank : 406)	NC score	0.084239 (rank : 614)
Query Neighborhood Hits	524	Target Neighborhood Hits	233	Shared Neighborhood Hits	113
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

HCFC2_MOUSE
θ value	1.06291 (rank : 407)	NC score	0.276856 (rank : 305)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

KV5E_MOUSE
θ value	1.06291 (rank : 408)	NC score	0.015817 (rank : 1200)
Query Neighborhood Hits	524	Target Neighborhood Hits	249	Shared Neighborhood Hits	49
SwissProt Accessions	P01637	Gene names
Domain Architecture
Description	Ig kappa chain V-V region T1 precursor.

SEM4D_HUMAN
θ value	1.06291 (rank : 409)	NC score	0.045561 (rank : 1175)
Query Neighborhood Hits	524	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q92854, Q7Z5S4	Gene names	SEMA4D, CD100
Domain Architecture
Description	Semaphorin-4D precursor (Leukocyte activation antigen CD100) (BB18) (A8) (GR3).

SIRB1_HUMAN
θ value	1.06291 (rank : 410)	NC score	0.171853 (rank : 402)
Query Neighborhood Hits	524	Target Neighborhood Hits	422	Shared Neighborhood Hits	134
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

TRI18_HUMAN
θ value	1.06291 (rank : 411)	NC score	0.034033 (rank : 1182)
Query Neighborhood Hits	524	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

I11RA_HUMAN
θ value	1.38821 (rank : 412)	NC score	0.151157 (rank : 423)
Query Neighborhood Hits	524	Target Neighborhood Hits	138	Shared Neighborhood Hits	72
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

I12R1_HUMAN
θ value	1.38821 (rank : 413)	NC score	0.154177 (rank : 420)
Query Neighborhood Hits	524	Target Neighborhood Hits	78	Shared Neighborhood Hits	60
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

KV1A_HUMAN
θ value	1.38821 (rank : 414)	NC score	0.011548 (rank : 1209)
Query Neighborhood Hits	524	Target Neighborhood Hits	203	Shared Neighborhood Hits	38
SwissProt Accessions	P01593	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region AG.

KV1H_HUMAN
θ value	1.38821 (rank : 415)	NC score	0.011596 (rank : 1208)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	47
SwissProt Accessions	P01600	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Hau.

MUCM_MOUSE
θ value	1.38821 (rank : 416)	NC score	0.059585 (rank : 871)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	48
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

MUC_MOUSE
θ value	1.38821 (rank : 417)	NC score	0.060220 (rank : 858)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	48
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

SEM3C_HUMAN
θ value	1.38821 (rank : 418)	NC score	0.032191 (rank : 1186)
Query Neighborhood Hits	524	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q99985	Gene names	SEMA3C, SEMAE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

TARSH_HUMAN
θ value	1.38821 (rank : 419)	NC score	0.214800 (rank : 359)
Query Neighborhood Hits	524	Target Neighborhood Hits	768	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

CD79B_MOUSE
θ value	1.81305 (rank : 420)	NC score	0.070665 (rank : 697)
Query Neighborhood Hits	524	Target Neighborhood Hits	150	Shared Neighborhood Hits	51
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

HPLN2_MOUSE
θ value	1.81305 (rank : 421)	NC score	0.047416 (rank : 1174)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESM3	Gene names	Hapln2, Bral1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

IGSF8_MOUSE
θ value	1.81305 (rank : 422)	NC score	0.082966 (rank : 621)
Query Neighborhood Hits	524	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

KV1B_HUMAN
θ value	1.81305 (rank : 423)	NC score	0.008565 (rank : 1223)
Query Neighborhood Hits	524	Target Neighborhood Hits	244	Shared Neighborhood Hits	35
SwissProt Accessions	P01594	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region AU.

LY9_HUMAN
θ value	1.81305 (rank : 424)	NC score	0.088451 (rank : 599)
Query Neighborhood Hits	524	Target Neighborhood Hits	82	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

TIMD1_MOUSE
θ value	1.81305 (rank : 425)	NC score	0.060362 (rank : 852)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	52
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

CD79A_HUMAN
θ value	2.36792 (rank : 426)	NC score	0.202725 (rank : 370)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

IGSF8_HUMAN
θ value	2.36792 (rank : 427)	NC score	0.089019 (rank : 597)
Query Neighborhood Hits	524	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

KV1E_HUMAN
θ value	2.36792 (rank : 428)	NC score	0.009029 (rank : 1219)
Query Neighborhood Hits	524	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	P01597	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region DEE.

LSHR_HUMAN
θ value	2.36792 (rank : 429)	NC score	0.011109 (rank : 1212)
Query Neighborhood Hits	524	Target Neighborhood Hits	731	Shared Neighborhood Hits	31
SwissProt Accessions	P22888, Q14751, Q15996, Q9UEW9	Gene names	LHCGR, LCGR, LGR2, LHRHR
Domain Architecture
Description	Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH- R) (Luteinizing hormone receptor) (LHR).

MADCA_MOUSE
θ value	2.36792 (rank : 430)	NC score	0.042712 (rank : 1176)
Query Neighborhood Hits	524	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

SGOL2_MOUSE
θ value	2.36792 (rank : 431)	NC score	0.008436 (rank : 1224)
Query Neighborhood Hits	524	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55	Gene names	Sgol2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2.

SIGIR_MOUSE
θ value	2.36792 (rank : 432)	NC score	0.110704 (rank : 526)
Query Neighborhood Hits	524	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

TDP1_MOUSE
θ value	2.36792 (rank : 433)	NC score	0.008366 (rank : 1225)
Query Neighborhood Hits	524	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q08639	Gene names	Tfdp1
Domain Architecture
Description	Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1- polypeptide 1).

HCFC2_HUMAN
θ value	3.0926 (rank : 434)	NC score	0.178611 (rank : 401)
Query Neighborhood Hits	524	Target Neighborhood Hits	154	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

I27RA_MOUSE
θ value	3.0926 (rank : 435)	NC score	0.096261 (rank : 569)
Query Neighborhood Hits	524	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

KV1C_HUMAN
θ value	3.0926 (rank : 436)	NC score	0.010367 (rank : 1214)
Query Neighborhood Hits	524	Target Neighborhood Hits	257	Shared Neighborhood Hits	44
SwissProt Accessions	P01595	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Bi.

KV1Q_HUMAN
θ value	3.0926 (rank : 437)	NC score	0.014279 (rank : 1201)
Query Neighborhood Hits	524	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	P01609	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Scw.

KV1T_HUMAN
θ value	3.0926 (rank : 438)	NC score	0.008839 (rank : 1220)
Query Neighborhood Hits	524	Target Neighborhood Hits	256	Shared Neighborhood Hits	40
SwissProt Accessions	P01612	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Mev.

KV1W_HUMAN
θ value	3.0926 (rank : 439)	NC score	0.008581 (rank : 1222)
Query Neighborhood Hits	524	Target Neighborhood Hits	299	Shared Neighborhood Hits	47
SwissProt Accessions	P04431	Gene names
Domain Architecture
Description	Ig kappa chain V-I region Walker precursor.

KV5B_MOUSE
θ value	3.0926 (rank : 440)	NC score	0.014004 (rank : 1202)
Query Neighborhood Hits	524	Target Neighborhood Hits	253	Shared Neighborhood Hits	55
SwissProt Accessions	P01634	Gene names
Domain Architecture
Description	Ig kappa chain V-V region MOPC 21 precursor.

KV5D_MOUSE
θ value	3.0926 (rank : 441)	NC score	0.017324 (rank : 1198)
Query Neighborhood Hits	524	Target Neighborhood Hits	255	Shared Neighborhood Hits	56
SwissProt Accessions	P01636	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region MOPC 149.

PKD1_HUMAN
θ value	3.0926 (rank : 442)	NC score	0.069006 (rank : 716)
Query Neighborhood Hits	524	Target Neighborhood Hits	387	Shared Neighborhood Hits	49
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PTPRU_HUMAN
θ value	3.0926 (rank : 443)	NC score	0.290085 (rank : 286)
Query Neighborhood Hits	524	Target Neighborhood Hits	237	Shared Neighborhood Hits	149
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

SIG12_HUMAN
θ value	3.0926 (rank : 444)	NC score	0.349739 (rank : 240)
Query Neighborhood Hits	524	Target Neighborhood Hits	245	Shared Neighborhood Hits	219
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

SIG12_MOUSE
θ value	3.0926 (rank : 445)	NC score	0.248828 (rank : 331)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	170
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

TRIM9_MOUSE
θ value	3.0926 (rank : 446)	NC score	0.065005 (rank : 757)
Query Neighborhood Hits	524	Target Neighborhood Hits	274	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

TTLL4_HUMAN
θ value	3.0926 (rank : 447)	NC score	0.006843 (rank : 1229)
Query Neighborhood Hits	524	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q14679, Q8WW29	Gene names	TTLL4, KIAA0173
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 4.

UNC5B_HUMAN
θ value	3.0926 (rank : 448)	NC score	0.251778 (rank : 326)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	134
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5B_MOUSE
θ value	3.0926 (rank : 449)	NC score	0.246980 (rank : 332)
Query Neighborhood Hits	524	Target Neighborhood Hits	226	Shared Neighborhood Hits	135
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5C_HUMAN
θ value	3.0926 (rank : 450)	NC score	0.264090 (rank : 317)
Query Neighborhood Hits	524	Target Neighborhood Hits	226	Shared Neighborhood Hits	129
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	3.0926 (rank : 451)	NC score	0.264724 (rank : 316)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	133
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

ZPBP2_HUMAN
θ value	3.0926 (rank : 452)	NC score	0.021908 (rank : 1192)
Query Neighborhood Hits	524	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	Q6X784, Q6X783, Q86XL5	Gene names	ZPBP2, ZPBPL
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 2 precursor (ZPBP-like protein).

BT2A1_HUMAN
θ value	4.03905 (rank : 453)	NC score	0.032297 (rank : 1185)
Query Neighborhood Hits	524	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

BTNL8_HUMAN
θ value	4.03905 (rank : 454)	NC score	0.049868 (rank : 1172)
Query Neighborhood Hits	524	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

CD226_MOUSE
θ value	4.03905 (rank : 455)	NC score	0.093960 (rank : 577)
Query Neighborhood Hits	524	Target Neighborhood Hits	64	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K4F0	Gene names	Cd226, Pta1
Domain Architecture
Description	CD226 antigen precursor (Platelet and T-cell activation antigen 1).

CD86_MOUSE
θ value	4.03905 (rank : 456)	NC score	0.096428 (rank : 568)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	P42082	Gene names	Cd86
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (Early T-cell costimulatory molecule 1) (ETC-1).

CEAM3_HUMAN
θ value	4.03905 (rank : 457)	NC score	0.132336 (rank : 453)
Query Neighborhood Hits	524	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

FIBA_HUMAN
θ value	4.03905 (rank : 458)	NC score	0.028239 (rank : 1188)
Query Neighborhood Hits	524	Target Neighborhood Hits	132	Shared Neighborhood Hits	10
SwissProt Accessions	P02671, Q9BX62, Q9UCH2	Gene names	FGA
Domain Architecture
Description	Fibrinogen alpha chain precursor [Contains: Fibrinopeptide A].

IL1AP_MOUSE
θ value	4.03905 (rank : 459)	NC score	0.108157 (rank : 547)
Query Neighborhood Hits	524	Target Neighborhood Hits	94	Shared Neighborhood Hits	60
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

KV1O_HUMAN
θ value	4.03905 (rank : 460)	NC score	0.010080 (rank : 1216)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	40
SwissProt Accessions	P01607	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Rei.

KV1X_HUMAN
θ value	4.03905 (rank : 461)	NC score	0.008229 (rank : 1226)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	40
SwissProt Accessions	P04432	Gene names
Domain Architecture
Description	Ig kappa chain V-I region Daudi precursor.

LAG3_MOUSE
θ value	4.03905 (rank : 462)	NC score	0.209222 (rank : 363)
Query Neighborhood Hits	524	Target Neighborhood Hits	117	Shared Neighborhood Hits	93
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

MPIP2_MOUSE
θ value	4.03905 (rank : 463)	NC score	0.003827 (rank : 1237)
Query Neighborhood Hits	524	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P30306, Q99LP3	Gene names	Cdc25b, Cdc25m2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

PCD16_HUMAN
θ value	4.03905 (rank : 464)	NC score	-0.003813 (rank : 1249)
Query Neighborhood Hits	524	Target Neighborhood Hits	245	Shared Neighborhood Hits	11
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

PDL1_MOUSE
θ value	4.03905 (rank : 465)	NC score	0.272548 (rank : 308)
Query Neighborhood Hits	524	Target Neighborhood Hits	168	Shared Neighborhood Hits	134
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

R3HD1_HUMAN
θ value	4.03905 (rank : 466)	NC score	0.009926 (rank : 1217)
Query Neighborhood Hits	524	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

SEM3B_HUMAN
θ value	4.03905 (rank : 467)	NC score	0.007500 (rank : 1228)
Query Neighborhood Hits	524	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).

SEM3C_MOUSE
θ value	4.03905 (rank : 468)	NC score	0.035803 (rank : 1181)
Query Neighborhood Hits	524	Target Neighborhood Hits	113	Shared Neighborhood Hits	55
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

SHPS1_HUMAN
θ value	4.03905 (rank : 469)	NC score	0.193289 (rank : 382)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	143
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

BT2A2_HUMAN
θ value	5.27518 (rank : 470)	NC score	0.033520 (rank : 1183)
Query Neighborhood Hits	524	Target Neighborhood Hits	191	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

CTLA4_MOUSE
θ value	5.27518 (rank : 471)	NC score	0.011800 (rank : 1206)
Query Neighborhood Hits	524	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P09793, Q9QZZ7	Gene names	Ctla4, Cd152
Domain Architecture
Description	Cytotoxic T-lymphocyte protein 4 precursor (Cytotoxic T-lymphocyte- associated antigen 4) (CTLA-4) (CD152 antigen).

FCERA_HUMAN
θ value	5.27518 (rank : 472)	NC score	0.245062 (rank : 334)
Query Neighborhood Hits	524	Target Neighborhood Hits	150	Shared Neighborhood Hits	118
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

HRX_HUMAN
θ value	5.27518 (rank : 473)	NC score	-0.002385 (rank : 1247)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	15
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IL9R_MOUSE
θ value	5.27518 (rank : 474)	NC score	0.011505 (rank : 1210)
Query Neighborhood Hits	524	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q01114	Gene names	Il9r
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

KV1D_HUMAN
θ value	5.27518 (rank : 475)	NC score	0.005952 (rank : 1230)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P01596	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region CAR.

KV1F_HUMAN
θ value	5.27518 (rank : 476)	NC score	0.009430 (rank : 1218)
Query Neighborhood Hits	524	Target Neighborhood Hits	261	Shared Neighborhood Hits	42
SwissProt Accessions	P01598	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region EU.

KV1K_HUMAN
θ value	5.27518 (rank : 477)	NC score	0.005804 (rank : 1232)
Query Neighborhood Hits	524	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	P01603	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Ka.

KV1M_HUMAN
θ value	5.27518 (rank : 478)	NC score	0.011784 (rank : 1207)
Query Neighborhood Hits	524	Target Neighborhood Hits	249	Shared Neighborhood Hits	47
SwissProt Accessions	P01605	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Lay.

MDR1_MOUSE
θ value	5.27518 (rank : 479)	NC score	-0.003078 (rank : 1248)
Query Neighborhood Hits	524	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	P06795	Gene names	Abcb1, Abcb1b, Mdr1, Mdr1b, Pgy1, Pgy1-1
Domain Architecture
Description	Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD243 antigen).

MPZL1_HUMAN
θ value	5.27518 (rank : 480)	NC score	0.028473 (rank : 1187)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	O95297, Q5R332, Q8IX11, Q9BWZ3, Q9NYK4, Q9UL20	Gene names	MPZL1, PZR
Domain Architecture	No domain graphic available
Description	Myelin protein zero-like protein 1 precursor (Protein zero-related).

OX2G_MOUSE
θ value	5.27518 (rank : 481)	NC score	0.232443 (rank : 341)
Query Neighborhood Hits	524	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

PDL2_MOUSE
θ value	5.27518 (rank : 482)	NC score	0.252303 (rank : 325)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	102
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PTPRO_HUMAN
θ value	5.27518 (rank : 483)	NC score	0.151324 (rank : 422)
Query Neighborhood Hits	524	Target Neighborhood Hits	139	Shared Neighborhood Hits	60
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

SIGIR_HUMAN
θ value	5.27518 (rank : 484)	NC score	0.058780 (rank : 886)
Query Neighborhood Hits	524	Target Neighborhood Hits	53	Shared Neighborhood Hits	27
SwissProt Accessions	Q6IA17, Q3KQY2, Q6UXI3, Q9H733	Gene names	SIGIRR
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

SRRM2_HUMAN
θ value	5.27518 (rank : 485)	NC score	0.016519 (rank : 1199)
Query Neighborhood Hits	524	Target Neighborhood Hits	1296	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TIMD1_HUMAN
θ value	5.27518 (rank : 486)	NC score	0.063904 (rank : 770)
Query Neighborhood Hits	524	Target Neighborhood Hits	155	Shared Neighborhood Hits	55
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

TIMD3_HUMAN
θ value	5.27518 (rank : 487)	NC score	0.040797 (rank : 1179)
Query Neighborhood Hits	524	Target Neighborhood Hits	62	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TDQ0, Q8WW60, Q96K94	Gene names	HAVCR2, TIM3, TIMD3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

TRIM1_MOUSE
θ value	5.27518 (rank : 488)	NC score	0.032651 (rank : 1184)
Query Neighborhood Hits	524	Target Neighborhood Hits	361	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

TTLL4_MOUSE
θ value	5.27518 (rank : 489)	NC score	0.004685 (rank : 1234)
Query Neighborhood Hits	524	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

2DMB_HUMAN
θ value	6.88961 (rank : 490)	NC score	0.005838 (rank : 1231)
Query Neighborhood Hits	524	Target Neighborhood Hits	216	Shared Neighborhood Hits	22
SwissProt Accessions	P28068, O77936, Q13012, Q29751, Q9XRX2	Gene names	HLA-DMB, DMB, RING7
Domain Architecture
Description	HLA class II histocompatibility antigen, DM beta chain precursor (MHC class II antigen DMB).

BCAR1_HUMAN
θ value	6.88961 (rank : 491)	NC score	0.001622 (rank : 1242)
Query Neighborhood Hits	524	Target Neighborhood Hits	554	Shared Neighborhood Hits	11
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

HCFC1_MOUSE
θ value	6.88961 (rank : 492)	NC score	0.110454 (rank : 529)
Query Neighborhood Hits	524	Target Neighborhood Hits	348	Shared Neighborhood Hits	66
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

I12R1_MOUSE
θ value	6.88961 (rank : 493)	NC score	0.144896 (rank : 431)
Query Neighborhood Hits	524	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

IRS1_HUMAN
θ value	6.88961 (rank : 494)	NC score	0.003010 (rank : 1239)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

JHD3B_MOUSE
θ value	6.88961 (rank : 495)	NC score	0.002284 (rank : 1240)
Query Neighborhood Hits	524	Target Neighborhood Hits	152	Shared Neighborhood Hits	9
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

KV1S_HUMAN
θ value	6.88961 (rank : 496)	NC score	0.010347 (rank : 1215)
Query Neighborhood Hits	524	Target Neighborhood Hits	237	Shared Neighborhood Hits	46
SwissProt Accessions	P01611	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Wes.

KV5O_MOUSE
θ value	6.88961 (rank : 497)	NC score	0.013019 (rank : 1203)
Query Neighborhood Hits	524	Target Neighborhood Hits	211	Shared Neighborhood Hits	44
SwissProt Accessions	P01648	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region HP 91A3.

KV5P_MOUSE
θ value	6.88961 (rank : 498)	NC score	0.005569 (rank : 1233)
Query Neighborhood Hits	524	Target Neighborhood Hits	193	Shared Neighborhood Hits	32
SwissProt Accessions	P01649	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V regions (Anti-arsonate antibodies).

LV2C_HUMAN
θ value	6.88961 (rank : 499)	NC score	0.003924 (rank : 1236)
Query Neighborhood Hits	524	Target Neighborhood Hits	257	Shared Neighborhood Hits	34
SwissProt Accessions	P01706	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region BOH.

MAML1_MOUSE
θ value	6.88961 (rank : 500)	NC score	0.000641 (rank : 1243)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

SCN2B_MOUSE
θ value	6.88961 (rank : 501)	NC score	0.060467 (rank : 848)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	47
SwissProt Accessions	Q56A07	Gene names	Scn2b
Domain Architecture	No domain graphic available
Description	Sodium channel beta-2 subunit precursor.

SEM3B_MOUSE
θ value	6.88961 (rank : 502)	NC score	0.007896 (rank : 1227)
Query Neighborhood Hits	524	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q62177	Gene names	Sema3b, Sema, Semaa
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin A) (Sema A).

SEM3F_HUMAN
θ value	6.88961 (rank : 503)	NC score	0.024837 (rank : 1190)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	Q13275, Q13274, Q13372, Q15704	Gene names	SEMA3F
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV) (Sema III/F).

SIGL8_HUMAN
θ value	6.88961 (rank : 504)	NC score	0.363320 (rank : 224)
Query Neighborhood Hits	524	Target Neighborhood Hits	252	Shared Neighborhood Hits	218
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

SRRM2_MOUSE
θ value	6.88961 (rank : 505)	NC score	0.021743 (rank : 1193)
Query Neighborhood Hits	524	Target Neighborhood Hits	1470	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TARA_MOUSE
θ value	6.88961 (rank : 506)	NC score	0.003261 (rank : 1238)
Query Neighborhood Hits	524	Target Neighborhood Hits	1133	Shared Neighborhood Hits	22
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

UBDC1_MOUSE
θ value	6.88961 (rank : 507)	NC score	0.003950 (rank : 1235)
Query Neighborhood Hits	524	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDI7, Q3TZH3	Gene names	Ubadc1, Kpc2
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated domain-containing protein 1 (E3 ubiquitin-protein ligase subunit KPC2) (Kip1 ubiquitination-promoting complex protein 2).

AKA12_HUMAN
θ value	8.99809 (rank : 508)	NC score	0.000541 (rank : 1244)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	12
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

AMGO3_HUMAN
θ value	8.99809 (rank : 509)	NC score	0.125343 (rank : 467)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	86
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ANLN_MOUSE
θ value	8.99809 (rank : 510)	NC score	0.001942 (rank : 1241)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CD80_HUMAN
θ value	8.99809 (rank : 511)	NC score	0.221205 (rank : 352)
Query Neighborhood Hits	524	Target Neighborhood Hits	129	Shared Neighborhood Hits	108
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

CD8A_MOUSE
θ value	8.99809 (rank : 512)	NC score	0.035933 (rank : 1180)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	P01731	Gene names	Cd8a, Lyt-2, Lyt2
Domain Architecture
Description	T-cell surface glycoprotein CD8 alpha chain precursor (T-cell surface glycoprotein Lyt-2) (CD8a antigen).

CEAMA_MOUSE
θ value	8.99809 (rank : 513)	NC score	0.133619 (rank : 451)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

CELR3_MOUSE
θ value	8.99809 (rank : 514)	NC score	0.012088 (rank : 1205)
Query Neighborhood Hits	524	Target Neighborhood Hits	687	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZI0, Q9ESD0	Gene names	Celsr3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor.

CTND1_MOUSE
θ value	8.99809 (rank : 515)	NC score	0.000359 (rank : 1245)
Query Neighborhood Hits	524	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

HV1D_HUMAN
θ value	8.99809 (rank : 516)	NC score	-0.004182 (rank : 1250)
Query Neighborhood Hits	524	Target Neighborhood Hits	183	Shared Neighborhood Hits	18
SwissProt Accessions	P01760	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V-I region WOL.

KPCI_HUMAN
θ value	8.99809 (rank : 517)	NC score	0.041204 (rank : 1178)
Query Neighborhood Hits	524	Target Neighborhood Hits	885	Shared Neighborhood Hits	84
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	8.99809 (rank : 518)	NC score	0.041258 (rank : 1177)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	84
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KV1G_HUMAN
θ value	8.99809 (rank : 519)	NC score	0.010691 (rank : 1213)
Query Neighborhood Hits	524	Target Neighborhood Hits	241	Shared Neighborhood Hits	45
SwissProt Accessions	P01599	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Gal.

KV1R_HUMAN
θ value	8.99809 (rank : 520)	NC score	0.008584 (rank : 1221)
Query Neighborhood Hits	524	Target Neighborhood Hits	253	Shared Neighborhood Hits	42
SwissProt Accessions	P01610	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region WEA.

KV3H_HUMAN
θ value	8.99809 (rank : 521)	NC score	0.012902 (rank : 1204)
Query Neighborhood Hits	524	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	P04207	Gene names
Domain Architecture
Description	Ig kappa chain V-III region CLL precursor (Rheumatoid factor).

NCTR2_HUMAN
θ value	8.99809 (rank : 522)	NC score	0.027636 (rank : 1189)
Query Neighborhood Hits	524	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	O95944, Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2	Gene names	NCR2, LY95
Domain Architecture
Description	Natural cytotoxicity triggering receptor 2 precursor (Natural killer cell p44-related protein) (NKp44) (NK-p44) (NK cell-activating receptor) (Lymphocyte antigen 95 homolog) (CD336 antigen).

PKHA6_MOUSE
θ value	8.99809 (rank : 523)	NC score	-0.000865 (rank : 1246)
Query Neighborhood Hits	524	Target Neighborhood Hits	591	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SIGL6_HUMAN
θ value	8.99809 (rank : 524)	NC score	0.341991 (rank : 246)
Query Neighborhood Hits	524	Target Neighborhood Hits	233	Shared Neighborhood Hits	202
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

A1BG_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.092395 (rank : 583)
Query Neighborhood Hits	524	Target Neighborhood Hits	94	Shared Neighborhood Hits	48
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

A2GL_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.063605 (rank : 779)
Query Neighborhood Hits	524	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	P02750, Q8N4F5, Q96QZ4	Gene names	LRG1, LRG
Domain Architecture
Description	Leucine-rich alpha-2-glycoprotein precursor (LRG).

AAPK1_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.058101 (rank : 903)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.057756 (rank : 911)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.056120 (rank : 959)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.125134 (rank : 470)
Query Neighborhood Hits	524	Target Neighborhood Hits	1243	Shared Neighborhood Hits	89
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.128810 (rank : 458)
Query Neighborhood Hits	524	Target Neighborhood Hits	942	Shared Neighborhood Hits	88
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.112677 (rank : 510)
Query Neighborhood Hits	524	Target Neighborhood Hits	1220	Shared Neighborhood Hits	87
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.113043 (rank : 506)
Query Neighborhood Hits	524	Target Neighborhood Hits	1178	Shared Neighborhood Hits	91
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.112957 (rank : 507)
Query Neighborhood Hits	524	Target Neighborhood Hits	1045	Shared Neighborhood Hits	85
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.124101 (rank : 474)
Query Neighborhood Hits	524	Target Neighborhood Hits	1140	Shared Neighborhood Hits	89
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.125319 (rank : 468)
Query Neighborhood Hits	524	Target Neighborhood Hits	1080	Shared Neighborhood Hits	90
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.054625 (rank : 1024)
Query Neighborhood Hits	524	Target Neighborhood Hits	753	Shared Neighborhood Hits	81
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.054990 (rank : 1002)
Query Neighborhood Hits	524	Target Neighborhood Hits	753	Shared Neighborhood Hits	81
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.059411 (rank : 875)
Query Neighborhood Hits	524	Target Neighborhood Hits	709	Shared Neighborhood Hits	80
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.055623 (rank : 979)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.069213 (rank : 714)
Query Neighborhood Hits	524	Target Neighborhood Hits	716	Shared Neighborhood Hits	76
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.071915 (rank : 690)
Query Neighborhood Hits	524	Target Neighborhood Hits	739	Shared Neighborhood Hits	77
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.060402 (rank : 850)
Query Neighborhood Hits	524	Target Neighborhood Hits	760	Shared Neighborhood Hits	80
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.061371 (rank : 820)
Query Neighborhood Hits	524	Target Neighborhood Hits	768	Shared Neighborhood Hits	80
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AGRIN_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.060191 (rank : 861)
Query Neighborhood Hits	524	Target Neighborhood Hits	582	Shared Neighborhood Hits	42
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

AL2S7_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.052173 (rank : 1100)
Query Neighborhood Hits	524	Target Neighborhood Hits	831	Shared Neighborhood Hits	82
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.140852 (rank : 438)
Query Neighborhood Hits	524	Target Neighborhood Hits	795	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.142080 (rank : 437)
Query Neighborhood Hits	524	Target Neighborhood Hits	811	Shared Neighborhood Hits	91
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALS_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.070898 (rank : 696)
Query Neighborhood Hits	524	Target Neighborhood Hits	280	Shared Neighborhood Hits	43
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

ALS_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.069025 (rank : 715)
Query Neighborhood Hits	524	Target Neighborhood Hits	275	Shared Neighborhood Hits	42
SwissProt Accessions	P70389, Q9DBI7	Gene names	Igfals, Albs, Als
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

AMGO1_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.100736 (rank : 562)
Query Neighborhood Hits	524	Target Neighborhood Hits	325	Shared Neighborhood Hits	89
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

AMHR2_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.055706 (rank : 978)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	78
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKF1_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.156977 (rank : 417)
Query Neighborhood Hits	524	Target Neighborhood Hits	126	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ANKK1_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.060139 (rank : 862)
Query Neighborhood Hits	524	Target Neighborhood Hits	1075	Shared Neighborhood Hits	82
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.062732 (rank : 792)
Query Neighborhood Hits	524	Target Neighborhood Hits	1072	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.075243 (rank : 673)
Query Neighborhood Hits	524	Target Neighborhood Hits	612	Shared Neighborhood Hits	77
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.074624 (rank : 678)
Query Neighborhood Hits	524	Target Neighborhood Hits	600	Shared Neighborhood Hits	77
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.070279 (rank : 703)
Query Neighborhood Hits	524	Target Neighborhood Hits	646	Shared Neighborhood Hits	77
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.069272 (rank : 710)
Query Neighborhood Hits	524	Target Neighborhood Hits	607	Shared Neighborhood Hits	77
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.090347 (rank : 590)
Query Neighborhood Hits	524	Target Neighborhood Hits	924	Shared Neighborhood Hits	85
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.090671 (rank : 587)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ASPN_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.062243 (rank : 802)
Query Neighborhood Hits	524	Target Neighborhood Hits	274	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BXN1, Q96K79, Q96LD0, Q9NXP3	Gene names	ASPN, PLAP1
Domain Architecture
Description	Asporin precursor (Periodontal ligament-associated protein 1) (PLAP- 1).

ASPN_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.062759 (rank : 791)
Query Neighborhood Hits	524	Target Neighborhood Hits	277	Shared Neighborhood Hits	42
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

AURKB_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.058799 (rank : 885)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.057151 (rank : 934)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.059698 (rank : 867)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.058501 (rank : 893)
Query Neighborhood Hits	524	Target Neighborhood Hits	844	Shared Neighborhood Hits	83
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AVR2A_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.055764 (rank : 973)
Query Neighborhood Hits	524	Target Neighborhood Hits	767	Shared Neighborhood Hits	79
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.055766 (rank : 972)
Query Neighborhood Hits	524	Target Neighborhood Hits	767	Shared Neighborhood Hits	79
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BLK_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.110971 (rank : 524)
Query Neighborhood Hits	524	Target Neighborhood Hits	994	Shared Neighborhood Hits	84
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.112011 (rank : 515)
Query Neighborhood Hits	524	Target Neighborhood Hits	992	Shared Neighborhood Hits	83
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMPR2_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.059425 (rank : 873)
Query Neighborhood Hits	524	Target Neighborhood Hits	736	Shared Neighborhood Hits	78
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.057652 (rank : 916)
Query Neighborhood Hits	524	Target Neighborhood Hits	738	Shared Neighborhood Hits	78
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.062080 (rank : 804)
Query Neighborhood Hits	524	Target Neighborhood Hits	759	Shared Neighborhood Hits	82
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.061969 (rank : 808)
Query Neighborhood Hits	524	Target Neighborhood Hits	758	Shared Neighborhood Hits	82
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.061668 (rank : 812)
Query Neighborhood Hits	524	Target Neighborhood Hits	760	Shared Neighborhood Hits	79
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.063095 (rank : 785)
Query Neighborhood Hits	524	Target Neighborhood Hits	758	Shared Neighborhood Hits	79
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.113551 (rank : 503)
Query Neighborhood Hits	524	Target Neighborhood Hits	942	Shared Neighborhood Hits	85
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.114557 (rank : 500)
Query Neighborhood Hits	524	Target Neighborhood Hits	912	Shared Neighborhood Hits	86
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.090542 (rank : 589)
Query Neighborhood Hits	524	Target Neighborhood Hits	883	Shared Neighborhood Hits	85
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRSK1_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.050878 (rank : 1146)
Query Neighborhood Hits	524	Target Neighborhood Hits	942	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.051481 (rank : 1124)
Query Neighborhood Hits	524	Target Neighborhood Hits	897	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

BTK_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.111651 (rank : 517)
Query Neighborhood Hits	524	Target Neighborhood Hits	1026	Shared Neighborhood Hits	86
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.111558 (rank : 519)
Query Neighborhood Hits	524	Target Neighborhood Hits	1017	Shared Neighborhood Hits	86
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTNL1_MOUSE
θ value	θ > 10 (rank : 585)	NC score	0.110249 (rank : 531)
Query Neighborhood Hits	524	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

CCRK_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.050989 (rank : 1140)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CD180_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.059402 (rank : 876)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	39
SwissProt Accessions	Q99467	Gene names	CD180, LY64, RP105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 64) (Radioprotective 105 kDa protein).

CD180_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.062677 (rank : 794)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	39
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

CD2L5_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.057738 (rank : 912)
Query Neighborhood Hits	524	Target Neighborhood Hits	987	Shared Neighborhood Hits	87
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.057629 (rank : 919)
Query Neighborhood Hits	524	Target Neighborhood Hits	1011	Shared Neighborhood Hits	86
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.059418 (rank : 874)
Query Neighborhood Hits	524	Target Neighborhood Hits	1275	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CD33_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.068952 (rank : 719)
Query Neighborhood Hits	524	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	P20138, Q8TD24	Gene names	CD33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3) (gp67).

CD33_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.062079 (rank : 805)
Query Neighborhood Hits	524	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	Q63994, Q63997	Gene names	Cd33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3).

CD45_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.127689 (rank : 461)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	63
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD48_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.117264 (rank : 495)
Query Neighborhood Hits	524	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

CD4_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.156907 (rank : 418)
Query Neighborhood Hits	524	Target Neighborhood Hits	122	Shared Neighborhood Hits	81
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

CD4_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.051233 (rank : 1131)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P06332	Gene names	Cd4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4).

CD79B_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.051160 (rank : 1134)
Query Neighborhood Hits	524	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	P40259, Q9BU06	Gene names	CD79B, B29, IGB
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

CD7_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.065843 (rank : 741)
Query Neighborhood Hits	524	Target Neighborhood Hits	190	Shared Neighborhood Hits	63
SwissProt Accessions	P09564	Gene names	CD7
Domain Architecture
Description	T-cell antigen CD7 precursor (GP40) (T-cell leukemia antigen) (TP41) (Leu-9).

CD7_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.065773 (rank : 742)
Query Neighborhood Hits	524	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	P50283	Gene names	Cd7
Domain Architecture
Description	T-cell antigen CD7 precursor.

CD86_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.082502 (rank : 625)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	P42081, Q13655, Q7M4L5	Gene names	CD86, CD28LG2
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63).

CDC2_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.056234 (rank : 955)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	82
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.055749 (rank : 974)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	82
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK2_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.056078 (rank : 961)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 605)	NC score	0.056046 (rank : 964)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	83
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.057686 (rank : 915)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	82
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 607)	NC score	0.052640 (rank : 1093)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	82
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK4_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.060920 (rank : 833)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	83
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	θ > 10 (rank : 609)	NC score	0.061539 (rank : 817)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	83
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK5_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.055896 (rank : 968)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	80
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.055983 (rank : 966)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	80
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK6_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.061250 (rank : 823)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	83
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 613)	NC score	0.061498 (rank : 818)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	83
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK7_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.055542 (rank : 982)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 615)	NC score	0.055993 (rank : 965)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	83
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK9_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.051208 (rank : 1132)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.051012 (rank : 1137)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDKL1_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.050925 (rank : 1145)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	81
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	θ > 10 (rank : 619)	NC score	0.050119 (rank : 1167)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	81
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.057138 (rank : 935)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	82
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.055019 (rank : 1001)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL3_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.054267 (rank : 1040)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.053790 (rank : 1057)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.052963 (rank : 1086)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	81
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.055215 (rank : 993)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	81
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.052000 (rank : 1107)
Query Neighborhood Hits	524	Target Neighborhood Hits	967	Shared Neighborhood Hits	87
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CEA19_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.080428 (rank : 638)
Query Neighborhood Hits	524	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

CHAD_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.073522 (rank : 681)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	42
SwissProt Accessions	O15335, Q96RJ5	Gene names	CHAD
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

CHAD_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.071544 (rank : 692)
Query Neighborhood Hits	524	Target Neighborhood Hits	260	Shared Neighborhood Hits	42
SwissProt Accessions	O55226	Gene names	Chad
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

CHK1_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.051010 (rank : 1138)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.050988 (rank : 1141)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	82
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CI096_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.050102 (rank : 1169)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CPN2_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.069005 (rank : 717)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	43
SwissProt Accessions	P22792, Q86SU4, Q8N5V4	Gene names	CPN2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

CPN2_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.068015 (rank : 729)
Query Neighborhood Hits	524	Target Neighborhood Hits	291	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

CRLF1_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.179779 (rank : 399)
Query Neighborhood Hits	524	Target Neighborhood Hits	122	Shared Neighborhood Hits	92
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CRLF1_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.171767 (rank : 403)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

CSF3R_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.300822 (rank : 277)
Query Neighborhood Hits	524	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSK_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.111327 (rank : 522)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.109443 (rank : 536)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPK1_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.055092 (rank : 998)
Query Neighborhood Hits	524	Target Neighborhood Hits	1130	Shared Neighborhood Hits	89
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.054575 (rank : 1029)
Query Neighborhood Hits	524	Target Neighborhood Hits	1138	Shared Neighborhood Hits	89
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.065109 (rank : 754)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.064996 (rank : 758)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	84
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.065010 (rank : 756)
Query Neighborhood Hits	524	Target Neighborhood Hits	945	Shared Neighborhood Hits	83
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.064667 (rank : 762)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK1_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.053338 (rank : 1077)
Query Neighborhood Hits	524	Target Neighborhood Hits	877	Shared Neighborhood Hits	84
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.053391 (rank : 1074)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK3_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.050571 (rank : 1159)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	85
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DDR1_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.135144 (rank : 449)
Query Neighborhood Hits	524	Target Neighborhood Hits	819	Shared Neighborhood Hits	85
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.135658 (rank : 448)
Query Neighborhood Hits	524	Target Neighborhood Hits	818	Shared Neighborhood Hits	85
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.132201 (rank : 454)
Query Neighborhood Hits	524	Target Neighborhood Hits	818	Shared Neighborhood Hits	86
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.131046 (rank : 456)
Query Neighborhood Hits	524	Target Neighborhood Hits	813	Shared Neighborhood Hits	86
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

E2AK1_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.056653 (rank : 942)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 654)	NC score	0.056738 (rank : 941)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.065301 (rank : 751)
Query Neighborhood Hits	524	Target Neighborhood Hits	856	Shared Neighborhood Hits	82
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.062319 (rank : 801)
Query Neighborhood Hits	524	Target Neighborhood Hits	864	Shared Neighborhood Hits	85
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.060940 (rank : 832)
Query Neighborhood Hits	524	Target Neighborhood Hits	859	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 658)	NC score	0.062546 (rank : 796)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

ECM2_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.055094 (rank : 997)
Query Neighborhood Hits	524	Target Neighborhood Hits	402	Shared Neighborhood Hits	37
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

EGFR_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.120645 (rank : 485)
Query Neighborhood Hits	524	Target Neighborhood Hits	939	Shared Neighborhood Hits	87
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.121106 (rank : 481)
Query Neighborhood Hits	524	Target Neighborhood Hits	927	Shared Neighborhood Hits	90
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.164888 (rank : 411)
Query Neighborhood Hits	524	Target Neighborhood Hits	997	Shared Neighborhood Hits	138
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.170359 (rank : 404)
Query Neighborhood Hits	524	Target Neighborhood Hits	958	Shared Neighborhood Hits	145
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA6_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.192387 (rank : 383)
Query Neighborhood Hits	524	Target Neighborhood Hits	959	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.183253 (rank : 393)
Query Neighborhood Hits	524	Target Neighborhood Hits	946	Shared Neighborhood Hits	153
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ERBB2_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.122596 (rank : 476)
Query Neighborhood Hits	524	Target Neighborhood Hits	1073	Shared Neighborhood Hits	90
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.122308 (rank : 478)
Query Neighborhood Hits	524	Target Neighborhood Hits	918	Shared Neighborhood Hits	87
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.123775 (rank : 475)
Query Neighborhood Hits	524	Target Neighborhood Hits	918	Shared Neighborhood Hits	85
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.122463 (rank : 477)
Query Neighborhood Hits	524	Target Neighborhood Hits	898	Shared Neighborhood Hits	84
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.121887 (rank : 479)
Query Neighborhood Hits	524	Target Neighborhood Hits	910	Shared Neighborhood Hits	91
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

FAK1_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.125103 (rank : 471)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.124792 (rank : 473)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.125779 (rank : 466)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.125057 (rank : 472)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FCERA_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.091183 (rank : 585)
Query Neighborhood Hits	524	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCG3A_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.095298 (rank : 571)
Query Neighborhood Hits	524	Target Neighborhood Hits	65	Shared Neighborhood Hits	51
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

FCG3B_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.107522 (rank : 548)
Query Neighborhood Hits	524	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

FCGR1_MOUSE
θ value	θ > 10 (rank : 678)	NC score	0.193999 (rank : 380)
Query Neighborhood Hits	524	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

FCGR2_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.094813 (rank : 573)
Query Neighborhood Hits	524	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

FCGR3_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.079929 (rank : 643)
Query Neighborhood Hits	524	Target Neighborhood Hits	98	Shared Neighborhood Hits	46
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

FCRLA_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.140841 (rank : 439)
Query Neighborhood Hits	524	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FCRLA_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.142383 (rank : 435)
Query Neighborhood Hits	524	Target Neighborhood Hits	110	Shared Neighborhood Hits	65
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FER_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.115961 (rank : 498)
Query Neighborhood Hits	524	Target Neighborhood Hits	1278	Shared Neighborhood Hits	84
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.118752 (rank : 489)
Query Neighborhood Hits	524	Target Neighborhood Hits	978	Shared Neighborhood Hits	83
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.118630 (rank : 490)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	83
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.109370 (rank : 538)
Query Neighborhood Hits	524	Target Neighborhood Hits	1067	Shared Neighborhood Hits	84
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.109411 (rank : 537)
Query Neighborhood Hits	524	Target Neighborhood Hits	1069	Shared Neighborhood Hits	84
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FLRT1_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.078595 (rank : 657)
Query Neighborhood Hits	524	Target Neighborhood Hits	286	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZU1	Gene names	FLRT1
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT1 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 1).

FLRT2_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.072020 (rank : 688)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	49
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

FLRT3_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.077306 (rank : 665)
Query Neighborhood Hits	524	Target Neighborhood Hits	281	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

FLT3_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.182492 (rank : 394)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	129
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FMOD_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.055897 (rank : 967)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	39
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

FMOD_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.054165 (rank : 1044)
Query Neighborhood Hits	524	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

FPRP_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.143437 (rank : 433)
Query Neighborhood Hits	524	Target Neighborhood Hits	130	Shared Neighborhood Hits	105
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

FPRP_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.132490 (rank : 452)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

FRK_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.111899 (rank : 516)
Query Neighborhood Hits	524	Target Neighborhood Hits	1058	Shared Neighborhood Hits	84
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.106223 (rank : 554)
Query Neighborhood Hits	524	Target Neighborhood Hits	1078	Shared Neighborhood Hits	84
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.107027 (rank : 550)
Query Neighborhood Hits	524	Target Neighborhood Hits	1073	Shared Neighborhood Hits	84
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GP124_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.068467 (rank : 726)
Query Neighborhood Hits	524	Target Neighborhood Hits	304	Shared Neighborhood Hits	50
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GP124_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.067671 (rank : 733)
Query Neighborhood Hits	524	Target Neighborhood Hits	423	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GP125_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.089260 (rank : 596)
Query Neighborhood Hits	524	Target Neighborhood Hits	327	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

GP125_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.090879 (rank : 586)
Query Neighborhood Hits	524	Target Neighborhood Hits	329	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

GP1BA_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.064519 (rank : 764)
Query Neighborhood Hits	524	Target Neighborhood Hits	407	Shared Neighborhood Hits	44
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

GP1BB_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.058607 (rank : 890)
Query Neighborhood Hits	524	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	P56400	Gene names	Gp1bb
Domain Architecture
Description	Platelet glycoprotein Ib beta chain precursor (GP-Ib beta) (GPIbB) (GPIb-beta) (CD42c antigen).

GPIX_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.060365 (rank : 851)
Query Neighborhood Hits	524	Target Neighborhood Hits	162	Shared Neighborhood Hits	39
SwissProt Accessions	P14770, Q14445, Q92525	Gene names	GP9
Domain Architecture
Description	Platelet glycoprotein IX precursor (GPIX) (CD42a antigen).

GPV_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.067216 (rank : 737)
Query Neighborhood Hits	524	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

GPV_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.069425 (rank : 709)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	41
SwissProt Accessions	O08742	Gene names	Gp5
Domain Architecture	No domain graphic available
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

GRK4_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.053103 (rank : 1081)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.054642 (rank : 1023)
Query Neighborhood Hits	524	Target Neighborhood Hits	808	Shared Neighborhood Hits	83
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.050874 (rank : 1147)
Query Neighborhood Hits	524	Target Neighborhood Hits	819	Shared Neighborhood Hits	83
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.050948 (rank : 1143)
Query Neighborhood Hits	524	Target Neighborhood Hits	823	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.051899 (rank : 1109)
Query Neighborhood Hits	524	Target Neighborhood Hits	823	Shared Neighborhood Hits	83
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.051729 (rank : 1117)
Query Neighborhood Hits	524	Target Neighborhood Hits	820	Shared Neighborhood Hits	83
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GUC2C_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.096969 (rank : 564)
Query Neighborhood Hits	524	Target Neighborhood Hits	624	Shared Neighborhood Hits	78
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.075151 (rank : 674)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	82
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.079878 (rank : 644)
Query Neighborhood Hits	524	Target Neighborhood Hits	692	Shared Neighborhood Hits	81
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.094462 (rank : 575)
Query Neighborhood Hits	524	Target Neighborhood Hits	740	Shared Neighborhood Hits	82
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.074889 (rank : 675)
Query Neighborhood Hits	524	Target Neighborhood Hits	644	Shared Neighborhood Hits	77
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCFC1_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.085086 (rank : 610)
Query Neighborhood Hits	524	Target Neighborhood Hits	331	Shared Neighborhood Hits	52
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

HCK_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.112454 (rank : 511)
Query Neighborhood Hits	524	Target Neighborhood Hits	1035	Shared Neighborhood Hits	85
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 721)	NC score	0.112846 (rank : 508)
Query Neighborhood Hits	524	Target Neighborhood Hits	1029	Shared Neighborhood Hits	84
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HUNK_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.052619 (rank : 1094)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	83
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 723)	NC score	0.052567 (rank : 1095)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

I18RA_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.108402 (rank : 544)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

I27RA_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.149289 (rank : 426)
Query Neighborhood Hits	524	Target Neighborhood Hits	60	Shared Neighborhood Hits	45
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

ICAM1_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.165226 (rank : 409)
Query Neighborhood Hits	524	Target Neighborhood Hits	80	Shared Neighborhood Hits	72
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

ICAM1_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.185754 (rank : 391)
Query Neighborhood Hits	524	Target Neighborhood Hits	99	Shared Neighborhood Hits	87
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

ICK_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.061313 (rank : 822)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 729)	NC score	0.060987 (rank : 830)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

ICOSL_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.081289 (rank : 632)
Query Neighborhood Hits	524	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

ICOSL_MOUSE
θ value	θ > 10 (rank : 731)	NC score	0.114166 (rank : 501)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

IGS21_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.265986 (rank : 315)
Query Neighborhood Hits	524	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGS21_MOUSE
θ value	θ > 10 (rank : 733)	NC score	0.263031 (rank : 319)
Query Neighborhood Hits	524	Target Neighborhood Hits	118	Shared Neighborhood Hits	106
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGSF2_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.158214 (rank : 415)
Query Neighborhood Hits	524	Target Neighborhood Hits	208	Shared Neighborhood Hits	110
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

IKKA_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.070487 (rank : 701)
Query Neighborhood Hits	524	Target Neighborhood Hits	863	Shared Neighborhood Hits	83
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.070386 (rank : 702)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.063792 (rank : 774)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	83
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.063462 (rank : 780)
Query Neighborhood Hits	524	Target Neighborhood Hits	984	Shared Neighborhood Hits	83
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.054028 (rank : 1046)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	80
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.053736 (rank : 1059)
Query Neighborhood Hits	524	Target Neighborhood Hits	848	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IL12B_MOUSE
θ value	θ > 10 (rank : 741)	NC score	0.053363 (rank : 1076)
Query Neighborhood Hits	524	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	P43432, Q9QUM1	Gene names	Il12b
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40).

IL18R_HUMAN
θ value	θ > 10 (rank : 742)	NC score	0.067504 (rank : 735)
Query Neighborhood Hits	524	Target Neighborhood Hits	81	Shared Neighborhood Hits	42
SwissProt Accessions	Q13478	Gene names	IL18R1, IL1RRP
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp) (CDw218a antigen).

IL18R_MOUSE
θ value	θ > 10 (rank : 743)	NC score	0.077677 (rank : 661)
Query Neighborhood Hits	524	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

ILK1_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.086763 (rank : 605)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	81
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.084421 (rank : 612)
Query Neighborhood Hits	524	Target Neighborhood Hits	848	Shared Neighborhood Hits	81
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.087234 (rank : 604)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	81
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILRL1_MOUSE
θ value	θ > 10 (rank : 747)	NC score	0.209662 (rank : 362)
Query Neighborhood Hits	524	Target Neighborhood Hits	172	Shared Neighborhood Hits	134
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

IRAK1_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.069229 (rank : 713)
Query Neighborhood Hits	524	Target Neighborhood Hits	820	Shared Neighborhood Hits	84
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.069430 (rank : 708)
Query Neighborhood Hits	524	Target Neighborhood Hits	784	Shared Neighborhood Hits	84
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.051584 (rank : 1120)
Query Neighborhood Hits	524	Target Neighborhood Hits	714	Shared Neighborhood Hits	67
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.072666 (rank : 687)
Query Neighborhood Hits	524	Target Neighborhood Hits	644	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 752)	NC score	0.079404 (rank : 650)
Query Neighborhood Hits	524	Target Neighborhood Hits	628	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 753)	NC score	0.081945 (rank : 626)
Query Neighborhood Hits	524	Target Neighborhood Hits	816	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.080053 (rank : 641)
Query Neighborhood Hits	524	Target Neighborhood Hits	820	Shared Neighborhood Hits	84
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.111533 (rank : 520)
Query Neighborhood Hits	524	Target Neighborhood Hits	1016	Shared Neighborhood Hits	85
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.112158 (rank : 513)
Query Neighborhood Hits	524	Target Neighborhood Hits	985	Shared Neighborhood Hits	84
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.110600 (rank : 527)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.110528 (rank : 528)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	83
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.108313 (rank : 545)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.108255 (rank : 546)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	83
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.110201 (rank : 532)
Query Neighborhood Hits	524	Target Neighborhood Hits	827	Shared Neighborhood Hits	83
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.106496 (rank : 552)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

K0999_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.053940 (rank : 1052)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.053955 (rank : 1050)
Query Neighborhood Hits	524	Target Neighborhood Hits	931	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KALM_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.283652 (rank : 293)
Query Neighborhood Hits	524	Target Neighborhood Hits	114	Shared Neighborhood Hits	76
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

KCC1A_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.055388 (rank : 987)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.055338 (rank : 988)
Query Neighborhood Hits	524	Target Neighborhood Hits	845	Shared Neighborhood Hits	83
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.052819 (rank : 1090)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 769)	NC score	0.053076 (rank : 1083)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.051547 (rank : 1122)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 771)	NC score	0.051745 (rank : 1116)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.051897 (rank : 1110)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 773)	NC score	0.051880 (rank : 1112)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KKCC1_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.053802 (rank : 1055)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.053721 (rank : 1060)
Query Neighborhood Hits	524	Target Neighborhood Hits	866	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.057194 (rank : 933)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.057137 (rank : 936)
Query Neighborhood Hits	524	Target Neighborhood Hits	855	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCA_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.051030 (rank : 1135)
Query Neighborhood Hits	524	Target Neighborhood Hits	1070	Shared Neighborhood Hits	83
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	θ > 10 (rank : 779)	NC score	0.052351 (rank : 1096)
Query Neighborhood Hits	524	Target Neighborhood Hits	1067	Shared Neighborhood Hits	83
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.051915 (rank : 1108)
Query Neighborhood Hits	524	Target Neighborhood Hits	1121	Shared Neighborhood Hits	83
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 781)	NC score	0.052201 (rank : 1099)
Query Neighborhood Hits	524	Target Neighborhood Hits	1117	Shared Neighborhood Hits	83
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.056630 (rank : 944)
Query Neighborhood Hits	524	Target Neighborhood Hits	900	Shared Neighborhood Hits	83
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.056070 (rank : 962)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	83
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.054988 (rank : 1003)
Query Neighborhood Hits	524	Target Neighborhood Hits	897	Shared Neighborhood Hits	83
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.054592 (rank : 1027)
Query Neighborhood Hits	524	Target Neighborhood Hits	895	Shared Neighborhood Hits	83
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPSH1_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.053253 (rank : 1079)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.053309 (rank : 1078)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	83
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.057134 (rank : 937)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A1_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.060946 (rank : 831)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	83
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.058098 (rank : 904)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.060833 (rank : 834)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 792)	NC score	0.060258 (rank : 856)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.061694 (rank : 811)
Query Neighborhood Hits	524	Target Neighborhood Hits	859	Shared Neighborhood Hits	83
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 794)	NC score	0.061639 (rank : 813)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	83
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A6_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.059235 (rank : 877)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.050667 (rank : 1154)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 797)	NC score	0.050716 (rank : 1151)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KSR1_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.086724 (rank : 606)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 799)	NC score	0.086632 (rank : 607)
Query Neighborhood Hits	524	Target Neighborhood Hits	870	Shared Neighborhood Hits	86
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 800)	NC score	0.077403 (rank : 663)
Query Neighborhood Hits	524	Target Neighborhood Hits	920	Shared Neighborhood Hits	85
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.121027 (rank : 482)
Query Neighborhood Hits	524	Target Neighborhood Hits	901	Shared Neighborhood Hits	83
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.120863 (rank : 483)
Query Neighborhood Hits	524	Target Neighborhood Hits	944	Shared Neighborhood Hits	84
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAG3_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.188666 (rank : 387)
Query Neighborhood Hits	524	Target Neighborhood Hits	129	Shared Neighborhood Hits	87
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LAMA5_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.052058 (rank : 1105)
Query Neighborhood Hits	524	Target Neighborhood Hits	976	Shared Neighborhood Hits	54
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMA5_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.053800 (rank : 1056)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	54
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LCK_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.112092 (rank : 514)
Query Neighborhood Hits	524	Target Neighborhood Hits	987	Shared Neighborhood Hits	85
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.111585 (rank : 518)
Query Neighborhood Hits	524	Target Neighborhood Hits	981	Shared Neighborhood Hits	83
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LGI1_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.058491 (rank : 894)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	O95970, Q5W001, Q5W002, Q8NI23, Q96LF5	Gene names	LGI1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor (Epitempin-1).

LGI1_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.058655 (rank : 888)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JIA1	Gene names	Lgi1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor.

LGI2_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.059013 (rank : 880)
Query Neighborhood Hits	524	Target Neighborhood Hits	232	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N0V4, Q8NDW6, Q96PX2, Q9NVK4	Gene names	LGI2, KIAA1916, LGIL2
Domain Architecture
Description	Leucine-rich repeat LGI family member 2 precursor (Leucine-rich glioma-inactivated protein 2) (LGI1-like protein 2).

LGI3_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.058265 (rank : 900)
Query Neighborhood Hits	524	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N145, Q86TL4, Q8N296	Gene names	LGI3, LGIL4
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (LGI1-like protein 4).

LGI3_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.056917 (rank : 939)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

LGI4_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.062052 (rank : 806)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N135	Gene names	LGI4, LGIL3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

LGI4_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.058397 (rank : 896)
Query Neighborhood Hits	524	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K1S1, Q8K4Y8	Gene names	Lgi4, Lgil3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

LGR4_HUMAN
θ value	θ > 10 (rank : 815)	NC score	0.059919 (rank : 865)
Query Neighborhood Hits	524	Target Neighborhood Hits	481	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

LGR5_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.061207 (rank : 825)
Query Neighborhood Hits	524	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

LGR5_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.060671 (rank : 841)
Query Neighborhood Hits	524	Target Neighborhood Hits	484	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1P4	Gene names	Lgr5, Fex, Gpr49
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX).

LGR6_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.059127 (rank : 879)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

LIMK1_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.083258 (rank : 618)
Query Neighborhood Hits	524	Target Neighborhood Hits	1005	Shared Neighborhood Hits	83
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 820)	NC score	0.083185 (rank : 619)
Query Neighborhood Hits	524	Target Neighborhood Hits	1008	Shared Neighborhood Hits	84
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.081738 (rank : 628)
Query Neighborhood Hits	524	Target Neighborhood Hits	986	Shared Neighborhood Hits	83
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.081595 (rank : 629)
Query Neighborhood Hits	524	Target Neighborhood Hits	998	Shared Neighborhood Hits	83
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIRA3_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.050086 (rank : 1170)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N6C8, O15469, O15470, O75016, Q8N151, Q8N154, Q8NHJ1, Q8NHJ2, Q8NHJ3, Q8NHJ4	Gene names	LILRA3, ILT6, LIR4
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily A member 3 precursor (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Immunoglobulin- like transcript 6) (ILT-6) (Monocyte inhibitory receptor HM43/HM31) (CD85e antigen).

LR37A_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.056475 (rank : 950)
Query Neighborhood Hits	524	Target Neighborhood Hits	720	Shared Neighborhood Hits	55
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

LR37B_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.061237 (rank : 824)
Query Neighborhood Hits	524	Target Neighborhood Hits	392	Shared Neighborhood Hits	43
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

LRC15_HUMAN
θ value	θ > 10 (rank : 826)	NC score	0.068773 (rank : 723)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

LRC15_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.071330 (rank : 695)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	42
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

LRC17_HUMAN
θ value	θ > 10 (rank : 828)	NC score	0.060485 (rank : 846)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

LRC17_MOUSE
θ value	θ > 10 (rank : 829)	NC score	0.064156 (rank : 769)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CXD9	Gene names	Lrrc17
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor.

LRC19_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.061565 (rank : 815)
Query Neighborhood Hits	524	Target Neighborhood Hits	217	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H756	Gene names	LRRC19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC19_MOUSE
θ value	θ > 10 (rank : 831)	NC score	0.063870 (rank : 772)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BZT5, Q6P8J1	Gene names	Lrrc19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC32_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.062844 (rank : 790)
Query Neighborhood Hits	524	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

LRC33_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.060288 (rank : 854)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC33_MOUSE
θ value	θ > 10 (rank : 834)	NC score	0.057472 (rank : 926)
Query Neighborhood Hits	524	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC3B_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.053508 (rank : 1069)
Query Neighborhood Hits	524	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q96PB8	Gene names	LRRC3B, LRP15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

LRC3B_MOUSE
θ value	θ > 10 (rank : 836)	NC score	0.053613 (rank : 1063)
Query Neighborhood Hits	524	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VCH9	Gene names	Lrrc3b, Lrp15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

LRC52_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.064492 (rank : 765)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N7C0, Q5T9K5	Gene names	LRRC52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC52_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.064334 (rank : 766)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	42
SwissProt Accessions	Q5M8M9	Gene names	Lrrc52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC55_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.063801 (rank : 773)
Query Neighborhood Hits	524	Target Neighborhood Hits	257	Shared Neighborhood Hits	40
SwissProt Accessions	Q6ZSA7	Gene names	LRRC55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

LRC55_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.063737 (rank : 776)
Query Neighborhood Hits	524	Target Neighborhood Hits	254	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UY51	Gene names	Lrrc55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

LRRC3_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.056236 (rank : 954)
Query Neighborhood Hits	524	Target Neighborhood Hits	232	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BY71	Gene names	LRRC3, C21orf102
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

LRRC3_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.062357 (rank : 800)
Query Neighborhood Hits	524	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	P59034	Gene names	Lrrc3
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

LRRK1_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.096659 (rank : 567)
Query Neighborhood Hits	524	Target Neighborhood Hits	1237	Shared Neighborhood Hits	120
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.099177 (rank : 563)
Query Neighborhood Hits	524	Target Neighborhood Hits	1267	Shared Neighborhood Hits	121
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.085467 (rank : 609)
Query Neighborhood Hits	524	Target Neighborhood Hits	1382	Shared Neighborhood Hits	115
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.083933 (rank : 615)
Query Neighborhood Hits	524	Target Neighborhood Hits	1359	Shared Neighborhood Hits	115
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LRTM1_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.065620 (rank : 746)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	40
SwissProt Accessions	Q86UE6, Q96DN1	Gene names	LRRTM1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

LRTM1_MOUSE
θ value	θ > 10 (rank : 848)	NC score	0.066822 (rank : 738)
Query Neighborhood Hits	524	Target Neighborhood Hits	264	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K377, Q3UVX1	Gene names	Lrrtm1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

LRTM2_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.065233 (rank : 752)
Query Neighborhood Hits	524	Target Neighborhood Hits	282	Shared Neighborhood Hits	42
SwissProt Accessions	O43300, Q7L770	Gene names	LRRTM2, KIAA0416, LRRN2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor (Leucine-rich repeat neuronal 2 protein).

LRTM2_MOUSE
θ value	θ > 10 (rank : 850)	NC score	0.065337 (rank : 750)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGA3, Q80U08	Gene names	Lrrtm2, Kiaa0416
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor.

LRTM3_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.063690 (rank : 778)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	42
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

LRTM3_MOUSE
θ value	θ > 10 (rank : 852)	NC score	0.063068 (rank : 786)
Query Neighborhood Hits	524	Target Neighborhood Hits	290	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

LRTM4_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.064621 (rank : 763)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

LRTM4_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.064972 (rank : 759)
Query Neighborhood Hits	524	Target Neighborhood Hits	284	Shared Neighborhood Hits	44
SwissProt Accessions	Q80XG9, Q8C030, Q8JZS8	Gene names	Lrrtm4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

LTK_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.143854 (rank : 432)
Query Neighborhood Hits	524	Target Neighborhood Hits	774	Shared Neighborhood Hits	85
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.143402 (rank : 434)
Query Neighborhood Hits	524	Target Neighborhood Hits	770	Shared Neighborhood Hits	83
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LUM_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.054301 (rank : 1039)
Query Neighborhood Hits	524	Target Neighborhood Hits	284	Shared Neighborhood Hits	37
SwissProt Accessions	P51884, Q96QM7	Gene names	LUM, LDC
Domain Architecture
Description	Lumican precursor (Keratan sulfate proteoglycan lumican) (KSPG lumican).

LUM_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.052164 (rank : 1101)
Query Neighborhood Hits	524	Target Neighborhood Hits	290	Shared Neighborhood Hits	38
SwissProt Accessions	P51885, Q3TP25, Q99JZ3, Q9CXK0	Gene names	Lum, Lcn, Ldc
Domain Architecture
Description	Lumican precursor (Keratan sulfate proteoglycan lumican) (KSPG lumican).

LYN_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.110168 (rank : 533)
Query Neighborhood Hits	524	Target Neighborhood Hits	1022	Shared Neighborhood Hits	85
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.110336 (rank : 530)
Query Neighborhood Hits	524	Target Neighborhood Hits	1023	Shared Neighborhood Hits	84
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 861)	NC score	0.092873 (rank : 581)
Query Neighborhood Hits	524	Target Neighborhood Hits	1071	Shared Neighborhood Hits	87
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.092500 (rank : 582)
Query Neighborhood Hits	524	Target Neighborhood Hits	1136	Shared Neighborhood Hits	89
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 863)	NC score	0.093851 (rank : 579)
Query Neighborhood Hits	524	Target Neighborhood Hits	940	Shared Neighborhood Hits	84
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 864)	NC score	0.093942 (rank : 578)
Query Neighborhood Hits	524	Target Neighborhood Hits	957	Shared Neighborhood Hits	85
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.091827 (rank : 584)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	84
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K15_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.058836 (rank : 883)
Query Neighborhood Hits	524	Target Neighborhood Hits	914	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.058108 (rank : 902)
Query Neighborhood Hits	524	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.050800 (rank : 1148)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.054715 (rank : 1017)
Query Neighborhood Hits	524	Target Neighborhood Hits	885	Shared Neighborhood Hits	85
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 870)	NC score	0.054550 (rank : 1031)
Query Neighborhood Hits	524	Target Neighborhood Hits	876	Shared Neighborhood Hits	84
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.052109 (rank : 1102)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.050939 (rank : 1144)
Query Neighborhood Hits	524	Target Neighborhood Hits	924	Shared Neighborhood Hits	81
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.057732 (rank : 913)
Query Neighborhood Hits	524	Target Neighborhood Hits	868	Shared Neighborhood Hits	83
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.057903 (rank : 906)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.054850 (rank : 1010)
Query Neighborhood Hits	524	Target Neighborhood Hits	889	Shared Neighborhood Hits	86
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K7_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.088160 (rank : 602)
Query Neighborhood Hits	524	Target Neighborhood Hits	892	Shared Neighborhood Hits	83
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 877)	NC score	0.088173 (rank : 601)
Query Neighborhood Hits	524	Target Neighborhood Hits	892	Shared Neighborhood Hits	83
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_HUMAN
θ value	θ > 10 (rank : 878)	NC score	0.054262 (rank : 1041)
Query Neighborhood Hits	524	Target Neighborhood Hits	807	Shared Neighborhood Hits	76
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 879)	NC score	0.052062 (rank : 1104)
Query Neighborhood Hits	524	Target Neighborhood Hits	815	Shared Neighborhood Hits	76
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K9_HUMAN
θ value	θ > 10 (rank : 880)	NC score	0.092953 (rank : 580)
Query Neighborhood Hits	524	Target Neighborhood Hits	1123	Shared Neighborhood Hits	86
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.096936 (rank : 565)
Query Neighborhood Hits	524	Target Neighborhood Hits	1087	Shared Neighborhood Hits	85
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.054743 (rank : 1015)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	83
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 883)	NC score	0.054903 (rank : 1006)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.050366 (rank : 1162)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	82
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K3_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.051888 (rank : 1111)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K4_HUMAN
θ value	θ > 10 (rank : 886)	NC score	0.051195 (rank : 1133)
Query Neighborhood Hits	524	Target Neighborhood Hits	1589	Shared Neighborhood Hits	85
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 887)	NC score	0.055086 (rank : 999)
Query Neighborhood Hits	524	Target Neighborhood Hits	1560	Shared Neighborhood Hits	86
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MAK_HUMAN
θ value	θ > 10 (rank : 888)	NC score	0.062368 (rank : 799)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	82
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 889)	NC score	0.062721 (rank : 793)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	83
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAMC2_HUMAN
θ value	θ > 10 (rank : 890)	NC score	0.058770 (rank : 887)
Query Neighborhood Hits	524	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAMC2_MOUSE
θ value	θ > 10 (rank : 891)	NC score	0.058371 (rank : 897)
Query Neighborhood Hits	524	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MARK1_HUMAN
θ value	θ > 10 (rank : 892)	NC score	0.055725 (rank : 976)
Query Neighborhood Hits	524	Target Neighborhood Hits	887	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 893)	NC score	0.055243 (rank : 991)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 894)	NC score	0.056067 (rank : 963)
Query Neighborhood Hits	524	Target Neighborhood Hits	1056	Shared Neighborhood Hits	92
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 895)	NC score	0.054622 (rank : 1025)
Query Neighborhood Hits	524	Target Neighborhood Hits	1018	Shared Neighborhood Hits	89
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.056534 (rank : 948)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	89
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 897)	NC score	0.055132 (rank : 995)
Query Neighborhood Hits	524	Target Neighborhood Hits	919	Shared Neighborhood Hits	87
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.053740 (rank : 1058)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 899)	NC score	0.053684 (rank : 1061)
Query Neighborhood Hits	524	Target Neighborhood Hits	898	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MATK_HUMAN
θ value	θ > 10 (rank : 900)	NC score	0.117301 (rank : 494)
Query Neighborhood Hits	524	Target Neighborhood Hits	954	Shared Neighborhood Hits	84
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.116545 (rank : 497)
Query Neighborhood Hits	524	Target Neighborhood Hits	952	Shared Neighborhood Hits	84
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MEGF9_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.050265 (rank : 1165)
Query Neighborhood Hits	524	Target Neighborhood Hits	557	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MELK_HUMAN
θ value	θ > 10 (rank : 903)	NC score	0.053519 (rank : 1068)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 904)	NC score	0.054109 (rank : 1045)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	84
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MET_HUMAN
θ value	θ > 10 (rank : 905)	NC score	0.126531 (rank : 464)
Query Neighborhood Hits	524	Target Neighborhood Hits	831	Shared Neighborhood Hits	83
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 906)	NC score	0.126703 (rank : 463)
Query Neighborhood Hits	524	Target Neighborhood Hits	844	Shared Neighborhood Hits	83
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MFAP3_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.164195 (rank : 412)
Query Neighborhood Hits	524	Target Neighborhood Hits	91	Shared Neighborhood Hits	82
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MFAP3_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.149851 (rank : 425)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

MINK1_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.055744 (rank : 975)
Query Neighborhood Hits	524	Target Neighborhood Hits	1477	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.055578 (rank : 981)
Query Neighborhood Hits	524	Target Neighborhood Hits	1451	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.054021 (rank : 1047)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 912)	NC score	0.053996 (rank : 1049)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.053824 (rank : 1054)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	82
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 914)	NC score	0.053597 (rank : 1064)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	83
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 915)	NC score	0.054987 (rank : 1004)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	80
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 916)	NC score	0.053555 (rank : 1067)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK06_HUMAN
θ value	θ > 10 (rank : 917)	NC score	0.050278 (rank : 1164)
Query Neighborhood Hits	524	Target Neighborhood Hits	815	Shared Neighborhood Hits	77
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 918)	NC score	0.050290 (rank : 1163)
Query Neighborhood Hits	524	Target Neighborhood Hits	818	Shared Neighborhood Hits	77
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK07_HUMAN
θ value	θ > 10 (rank : 919)	NC score	0.054866 (rank : 1008)
Query Neighborhood Hits	524	Target Neighborhood Hits	1087	Shared Neighborhood Hits	88
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	θ > 10 (rank : 920)	NC score	0.055493 (rank : 983)
Query Neighborhood Hits	524	Target Neighborhood Hits	1054	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK11_HUMAN
θ value	θ > 10 (rank : 921)	NC score	0.050985 (rank : 1142)
Query Neighborhood Hits	524	Target Neighborhood Hits	823	Shared Neighborhood Hits	81
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK12_HUMAN
θ value	θ > 10 (rank : 922)	NC score	0.050771 (rank : 1149)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	82
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK13_HUMAN
θ value	θ > 10 (rank : 923)	NC score	0.050606 (rank : 1158)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	82
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	θ > 10 (rank : 924)	NC score	0.050517 (rank : 1161)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	θ > 10 (rank : 925)	NC score	0.050661 (rank : 1155)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	82
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK15_HUMAN
θ value	θ > 10 (rank : 926)	NC score	0.051430 (rank : 1127)
Query Neighborhood Hits	524	Target Neighborhood Hits	1038	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MLKL_HUMAN
θ value	θ > 10 (rank : 927)	NC score	0.094687 (rank : 574)
Query Neighborhood Hits	524	Target Neighborhood Hits	600	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 928)	NC score	0.090044 (rank : 594)
Query Neighborhood Hits	524	Target Neighborhood Hits	707	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 929)	NC score	0.095158 (rank : 572)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 930)	NC score	0.095358 (rank : 570)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOG_MOUSE
θ value	θ > 10 (rank : 931)	NC score	0.060735 (rank : 837)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	67
SwissProt Accessions	Q61885, P70364, Q62003	Gene names	Mog
Domain Architecture
Description	Myelin-oligodendrocyte glycoprotein precursor.

MOK_HUMAN
θ value	θ > 10 (rank : 932)	NC score	0.053453 (rank : 1070)
Query Neighborhood Hits	524	Target Neighborhood Hits	807	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MOK_MOUSE
θ value	θ > 10 (rank : 933)	NC score	0.053868 (rank : 1053)
Query Neighborhood Hits	524	Target Neighborhood Hits	796	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MOS_HUMAN
θ value	θ > 10 (rank : 934)	NC score	0.088731 (rank : 598)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	83
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 935)	NC score	0.085585 (rank : 608)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 936)	NC score	0.053413 (rank : 1071)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 937)	NC score	0.053370 (rank : 1075)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 938)	NC score	0.053944 (rank : 1051)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 939)	NC score	0.052843 (rank : 1088)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	83
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 940)	NC score	0.055132 (rank : 994)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	83
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 941)	NC score	0.054421 (rank : 1035)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 942)	NC score	0.056493 (rank : 949)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 943)	NC score	0.056581 (rank : 947)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 944)	NC score	0.064290 (rank : 767)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 945)	NC score	0.065754 (rank : 743)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	84
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 946)	NC score	0.055834 (rank : 970)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 947)	NC score	0.055124 (rank : 996)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 948)	NC score	0.054853 (rank : 1009)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	82
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 949)	NC score	0.067853 (rank : 730)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	83
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 950)	NC score	0.067740 (rank : 732)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	83
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYLK2_HUMAN
θ value	θ > 10 (rank : 951)	NC score	0.067763 (rank : 731)
Query Neighborhood Hits	524	Target Neighborhood Hits	920	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYP0_HUMAN
θ value	θ > 10 (rank : 952)	NC score	0.058587 (rank : 891)
Query Neighborhood Hits	524	Target Neighborhood Hits	58	Shared Neighborhood Hits	42
SwissProt Accessions	P25189, Q16072, Q92677, Q9BR67	Gene names	MPZ
Domain Architecture
Description	Myelin P0 protein precursor (Myelin protein zero) (Myelin peripheral protein) (MPP).

MYP0_MOUSE
θ value	θ > 10 (rank : 953)	NC score	0.055047 (rank : 1000)
Query Neighborhood Hits	524	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	P27573	Gene names	Mpz, P0
Domain Architecture
Description	Myelin P0 protein precursor (Myelin protein zero) (Myelin peripheral protein) (MPP).

NEK11_HUMAN
θ value	θ > 10 (rank : 954)	NC score	0.068761 (rank : 724)
Query Neighborhood Hits	524	Target Neighborhood Hits	1043	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 955)	NC score	0.070121 (rank : 704)
Query Neighborhood Hits	524	Target Neighborhood Hits	875	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 956)	NC score	0.060241 (rank : 857)
Query Neighborhood Hits	524	Target Neighborhood Hits	1129	Shared Neighborhood Hits	85
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 957)	NC score	0.060195 (rank : 860)
Query Neighborhood Hits	524	Target Neighborhood Hits	1311	Shared Neighborhood Hits	86
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 958)	NC score	0.058865 (rank : 881)
Query Neighborhood Hits	524	Target Neighborhood Hits	908	Shared Neighborhood Hits	83
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 959)	NC score	0.055461 (rank : 985)
Query Neighborhood Hits	524	Target Neighborhood Hits	876	Shared Neighborhood Hits	83
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 960)	NC score	0.061075 (rank : 828)
Query Neighborhood Hits	524	Target Neighborhood Hits	865	Shared Neighborhood Hits	83
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 961)	NC score	0.060454 (rank : 849)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 962)	NC score	0.066068 (rank : 739)
Query Neighborhood Hits	524	Target Neighborhood Hits	883	Shared Neighborhood Hits	84
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 963)	NC score	0.065746 (rank : 744)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 964)	NC score	0.067622 (rank : 734)
Query Neighborhood Hits	524	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 965)	NC score	0.067403 (rank : 736)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 966)	NC score	0.068968 (rank : 718)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 967)	NC score	0.068812 (rank : 722)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 968)	NC score	0.057587 (rank : 920)
Query Neighborhood Hits	524	Target Neighborhood Hits	872	Shared Neighborhood Hits	83
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 969)	NC score	0.057645 (rank : 917)
Query Neighborhood Hits	524	Target Neighborhood Hits	872	Shared Neighborhood Hits	84
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 970)	NC score	0.060343 (rank : 853)
Query Neighborhood Hits	524	Target Neighborhood Hits	900	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 971)	NC score	0.059156 (rank : 878)
Query Neighborhood Hits	524	Target Neighborhood Hits	890	Shared Neighborhood Hits	84
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NIM1_HUMAN
θ value	θ > 10 (rank : 972)	NC score	0.054812 (rank : 1013)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 973)	NC score	0.052983 (rank : 1084)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NLK_HUMAN
θ value	θ > 10 (rank : 974)	NC score	0.054839 (rank : 1012)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	θ > 10 (rank : 975)	NC score	0.054841 (rank : 1011)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	85
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NRK_HUMAN
θ value	θ > 10 (rank : 976)	NC score	0.057304 (rank : 930)
Query Neighborhood Hits	524	Target Neighborhood Hits	931	Shared Neighborhood Hits	82
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 977)	NC score	0.054683 (rank : 1018)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NUAK1_HUMAN
θ value	θ > 10 (rank : 978)	NC score	0.057520 (rank : 924)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 979)	NC score	0.057223 (rank : 931)
Query Neighborhood Hits	524	Target Neighborhood Hits	881	Shared Neighborhood Hits	84
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 980)	NC score	0.059938 (rank : 864)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 981)	NC score	0.058423 (rank : 895)
Query Neighborhood Hits	524	Target Neighborhood Hits	878	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

NYX_HUMAN
θ value	θ > 10 (rank : 982)	NC score	0.073236 (rank : 683)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q9GZU5, Q5H983, Q9H4J0	Gene names	NYX, CLRP
Domain Architecture
Description	Nyctalopin precursor.

NYX_MOUSE
θ value	θ > 10 (rank : 983)	NC score	0.074008 (rank : 679)
Query Neighborhood Hits	524	Target Neighborhood Hits	241	Shared Neighborhood Hits	42
SwissProt Accessions	P83503, Q8BYN4	Gene names	Nyx
Domain Architecture
Description	Nyctalopin precursor.

OMD_HUMAN
θ value	θ > 10 (rank : 984)	NC score	0.051028 (rank : 1136)
Query Neighborhood Hits	524	Target Neighborhood Hits	275	Shared Neighborhood Hits	39
SwissProt Accessions	Q99983	Gene names	OMD
Domain Architecture
Description	Osteomodulin precursor (Osteoadherin) (OSAD) (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin).

OMGP_HUMAN
θ value	θ > 10 (rank : 985)	NC score	0.054417 (rank : 1036)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	38
SwissProt Accessions	P23515	Gene names	OMG, OMGP
Domain Architecture
Description	Oligodendrocyte-myelin glycoprotein precursor.

OMGP_MOUSE
θ value	θ > 10 (rank : 986)	NC score	0.054396 (rank : 1037)
Query Neighborhood Hits	524	Target Neighborhood Hits	280	Shared Neighborhood Hits	38
SwissProt Accessions	Q63912	Gene names	Omg, Omgp
Domain Architecture
Description	Oligodendrocyte-myelin glycoprotein precursor.

OX2G_HUMAN
θ value	θ > 10 (rank : 987)	NC score	0.211032 (rank : 360)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	88
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

OXSR1_HUMAN
θ value	θ > 10 (rank : 988)	NC score	0.061755 (rank : 810)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 989)	NC score	0.061425 (rank : 819)
Query Neighborhood Hits	524	Target Neighborhood Hits	865	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 990)	NC score	0.056474 (rank : 951)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 991)	NC score	0.056199 (rank : 956)
Query Neighborhood Hits	524	Target Neighborhood Hits	878	Shared Neighborhood Hits	84
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 992)	NC score	0.056078 (rank : 960)
Query Neighborhood Hits	524	Target Neighborhood Hits	862	Shared Neighborhood Hits	83
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 993)	NC score	0.056142 (rank : 958)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 994)	NC score	0.054558 (rank : 1030)
Query Neighborhood Hits	524	Target Neighborhood Hits	887	Shared Neighborhood Hits	84
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 995)	NC score	0.054666 (rank : 1020)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 996)	NC score	0.055606 (rank : 980)
Query Neighborhood Hits	524	Target Neighborhood Hits	924	Shared Neighborhood Hits	86
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 997)	NC score	0.055888 (rank : 969)
Query Neighborhood Hits	524	Target Neighborhood Hits	1098	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 998)	NC score	0.060083 (rank : 863)
Query Neighborhood Hits	524	Target Neighborhood Hits	915	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 999)	NC score	0.058307 (rank : 898)
Query Neighborhood Hits	524	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 1000)	NC score	0.057880 (rank : 907)
Query Neighborhood Hits	524	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PCTK1_HUMAN
θ value	θ > 10 (rank : 1001)	NC score	0.054225 (rank : 1043)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	82
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 1002)	NC score	0.054590 (rank : 1028)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	84
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 1003)	NC score	0.054446 (rank : 1033)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	81
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 1004)	NC score	0.054495 (rank : 1032)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 1005)	NC score	0.052821 (rank : 1089)
Query Neighborhood Hits	524	Target Neighborhood Hits	827	Shared Neighborhood Hits	80
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 1006)	NC score	0.053593 (rank : 1065)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	80
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDK1L_HUMAN
θ value	θ > 10 (rank : 1007)	NC score	0.052811 (rank : 1091)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 1008)	NC score	0.053088 (rank : 1082)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	82
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDL2_HUMAN
θ value	θ > 10 (rank : 1009)	NC score	0.197914 (rank : 375)
Query Neighborhood Hits	524	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PDPK1_HUMAN
θ value	θ > 10 (rank : 1010)	NC score	0.054438 (rank : 1034)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	θ > 10 (rank : 1011)	NC score	0.054608 (rank : 1026)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PFTK1_HUMAN
θ value	θ > 10 (rank : 1012)	NC score	0.052074 (rank : 1103)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	83
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 1013)	NC score	0.052026 (rank : 1106)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	83
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PGS1_HUMAN
θ value	θ > 10 (rank : 1014)	NC score	0.060665 (rank : 842)
Query Neighborhood Hits	524	Target Neighborhood Hits	261	Shared Neighborhood Hits	40
SwissProt Accessions	P21810, P13247	Gene names	BGN
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

PGS1_MOUSE
θ value	θ > 10 (rank : 1015)	NC score	0.060679 (rank : 840)
Query Neighborhood Hits	524	Target Neighborhood Hits	265	Shared Neighborhood Hits	40
SwissProt Accessions	P28653, Q61355	Gene names	Bgn
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

PGS2_HUMAN
θ value	θ > 10 (rank : 1016)	NC score	0.058278 (rank : 899)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	40
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

PGS2_MOUSE
θ value	θ > 10 (rank : 1017)	NC score	0.060206 (rank : 859)
Query Neighborhood Hits	524	Target Neighborhood Hits	285	Shared Neighborhood Hits	41
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

PIGR_HUMAN
θ value	θ > 10 (rank : 1018)	NC score	0.267978 (rank : 312)
Query Neighborhood Hits	524	Target Neighborhood Hits	164	Shared Neighborhood Hits	115
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PINK1_HUMAN
θ value	θ > 10 (rank : 1019)	NC score	0.050643 (rank : 1157)
Query Neighborhood Hits	524	Target Neighborhood Hits	741	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 1020)	NC score	0.056649 (rank : 943)
Query Neighborhood Hits	524	Target Neighborhood Hits	726	Shared Neighborhood Hits	76
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 1021)	NC score	0.060519 (rank : 845)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 1022)	NC score	0.060718 (rank : 838)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	83
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 1023)	NC score	0.057846 (rank : 909)
Query Neighborhood Hits	524	Target Neighborhood Hits	892	Shared Neighborhood Hits	83
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 1024)	NC score	0.057583 (rank : 921)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 1025)	NC score	0.056919 (rank : 938)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 1026)	NC score	0.057522 (rank : 923)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 1027)	NC score	0.058831 (rank : 884)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 1028)	NC score	0.056584 (rank : 946)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 1029)	NC score	0.058028 (rank : 905)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 1030)	NC score	0.058119 (rank : 901)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 1031)	NC score	0.056257 (rank : 953)
Query Neighborhood Hits	524	Target Neighborhood Hits	865	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 1032)	NC score	0.057198 (rank : 932)
Query Neighborhood Hits	524	Target Neighborhood Hits	863	Shared Neighborhood Hits	83
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 1033)	NC score	0.060477 (rank : 847)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	85
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 1034)	NC score	0.060825 (rank : 835)
Query Neighborhood Hits	524	Target Neighborhood Hits	879	Shared Neighborhood Hits	84
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PP1R7_HUMAN
θ value	θ > 10 (rank : 1035)	NC score	0.057876 (rank : 908)
Query Neighborhood Hits	524	Target Neighborhood Hits	265	Shared Neighborhood Hits	33
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

PP1R7_MOUSE
θ value	θ > 10 (rank : 1036)	NC score	0.054673 (rank : 1019)
Query Neighborhood Hits	524	Target Neighborhood Hits	256	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UM45, Q9CV31, Q9Z105	Gene names	Ppp1r7, Sds22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

PRELP_HUMAN
θ value	θ > 10 (rank : 1037)	NC score	0.051819 (rank : 1114)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	40
SwissProt Accessions	P51888	Gene names	PRELP
Domain Architecture
Description	Prolargin precursor (Proline-arginine-rich end leucine-rich repeat protein).

PRELP_MOUSE
θ value	θ > 10 (rank : 1038)	NC score	0.051753 (rank : 1115)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JK53	Gene names	Prelp
Domain Architecture
Description	Prolargin precursor (Proline-arginine-rich end leucine-rich repeat protein).

PRKX_MOUSE
θ value	θ > 10 (rank : 1039)	NC score	0.051398 (rank : 1128)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 1040)	NC score	0.053244 (rank : 1080)
Query Neighborhood Hits	524	Target Neighborhood Hits	844	Shared Neighborhood Hits	83
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PRLR_HUMAN
θ value	θ > 10 (rank : 1041)	NC score	0.069816 (rank : 706)
Query Neighborhood Hits	524	Target Neighborhood Hits	95	Shared Neighborhood Hits	51
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_MOUSE
θ value	θ > 10 (rank : 1042)	NC score	0.069717 (rank : 707)
Query Neighborhood Hits	524	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PTK6_HUMAN
θ value	θ > 10 (rank : 1043)	NC score	0.109919 (rank : 534)
Query Neighborhood Hits	524	Target Neighborhood Hits	1020	Shared Neighborhood Hits	84
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 1044)	NC score	0.112682 (rank : 509)
Query Neighborhood Hits	524	Target Neighborhood Hits	1026	Shared Neighborhood Hits	84
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 1045)	NC score	0.070614 (rank : 698)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 1046)	NC score	0.070609 (rank : 699)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 1047)	NC score	0.077148 (rank : 666)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 1048)	NC score	0.076693 (rank : 671)
Query Neighborhood Hits	524	Target Neighborhood Hits	123	Shared Neighborhood Hits	18
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN13_HUMAN
θ value	θ > 10 (rank : 1049)	NC score	0.053649 (rank : 1062)
Query Neighborhood Hits	524	Target Neighborhood Hits	471	Shared Neighborhood Hits	21
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
θ value	θ > 10 (rank : 1050)	NC score	0.054659 (rank : 1021)
Query Neighborhood Hits	524	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN14_HUMAN
θ value	θ > 10 (rank : 1051)	NC score	0.062200 (rank : 803)
Query Neighborhood Hits	524	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN14_MOUSE
θ value	θ > 10 (rank : 1052)	NC score	0.061775 (rank : 809)
Query Neighborhood Hits	524	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN18_HUMAN
θ value	θ > 10 (rank : 1053)	NC score	0.077389 (rank : 664)
Query Neighborhood Hits	524	Target Neighborhood Hits	73	Shared Neighborhood Hits	17
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 1054)	NC score	0.078067 (rank : 659)
Query Neighborhood Hits	524	Target Neighborhood Hits	134	Shared Neighborhood Hits	18
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 1055)	NC score	0.079097 (rank : 653)
Query Neighborhood Hits	524	Target Neighborhood Hits	84	Shared Neighborhood Hits	17
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 1056)	NC score	0.078967 (rank : 654)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN21_HUMAN
θ value	θ > 10 (rank : 1057)	NC score	0.061204 (rank : 826)
Query Neighborhood Hits	524	Target Neighborhood Hits	143	Shared Neighborhood Hits	17
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN21_MOUSE
θ value	θ > 10 (rank : 1058)	NC score	0.062035 (rank : 807)
Query Neighborhood Hits	524	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN22_HUMAN
θ value	θ > 10 (rank : 1059)	NC score	0.078775 (rank : 656)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 1060)	NC score	0.076751 (rank : 669)
Query Neighborhood Hits	524	Target Neighborhood Hits	179	Shared Neighborhood Hits	24
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 1061)	NC score	0.062864 (rank : 789)
Query Neighborhood Hits	524	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 1062)	NC score	0.065569 (rank : 747)
Query Neighborhood Hits	524	Target Neighborhood Hits	726	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 1063)	NC score	0.080363 (rank : 639)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	17
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 1064)	NC score	0.079808 (rank : 646)
Query Neighborhood Hits	524	Target Neighborhood Hits	107	Shared Neighborhood Hits	17
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN3_HUMAN
θ value	θ > 10 (rank : 1065)	NC score	0.059674 (rank : 868)
Query Neighborhood Hits	524	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN4_HUMAN
θ value	θ > 10 (rank : 1066)	NC score	0.057524 (rank : 922)
Query Neighborhood Hits	524	Target Neighborhood Hits	303	Shared Neighborhood Hits	18
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN5_HUMAN
θ value	θ > 10 (rank : 1067)	NC score	0.081106 (rank : 635)
Query Neighborhood Hits	524	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 1068)	NC score	0.081113 (rank : 634)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 1069)	NC score	0.072843 (rank : 685)
Query Neighborhood Hits	524	Target Neighborhood Hits	234	Shared Neighborhood Hits	20
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 1070)	NC score	0.072694 (rank : 686)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 1071)	NC score	0.081081 (rank : 636)
Query Neighborhood Hits	524	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 1072)	NC score	0.081178 (rank : 633)
Query Neighborhood Hits	524	Target Neighborhood Hits	71	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 1073)	NC score	0.081301 (rank : 631)
Query Neighborhood Hits	524	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 1074)	NC score	0.081568 (rank : 630)
Query Neighborhood Hits	524	Target Neighborhood Hits	78	Shared Neighborhood Hits	17
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 1075)	NC score	0.079439 (rank : 649)
Query Neighborhood Hits	524	Target Neighborhood Hits	103	Shared Neighborhood Hits	18
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 1076)	NC score	0.079863 (rank : 645)
Query Neighborhood Hits	524	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 1077)	NC score	0.102904 (rank : 559)
Query Neighborhood Hits	524	Target Neighborhood Hits	101	Shared Neighborhood Hits	18
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 1078)	NC score	0.102411 (rank : 561)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRE_HUMAN
θ value	θ > 10 (rank : 1079)	NC score	0.102778 (rank : 560)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	17
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 1080)	NC score	0.103044 (rank : 558)
Query Neighborhood Hits	524	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRG_HUMAN
θ value	θ > 10 (rank : 1081)	NC score	0.106400 (rank : 553)
Query Neighborhood Hits	524	Target Neighborhood Hits	231	Shared Neighborhood Hits	58
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	θ > 10 (rank : 1082)	NC score	0.105250 (rank : 555)
Query Neighborhood Hits	524	Target Neighborhood Hits	260	Shared Neighborhood Hits	58
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRN_HUMAN
θ value	θ > 10 (rank : 1083)	NC score	0.079999 (rank : 642)
Query Neighborhood Hits	524	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 1084)	NC score	0.080642 (rank : 637)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	24
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 1085)	NC score	0.079187 (rank : 652)
Query Neighborhood Hits	524	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 1086)	NC score	0.079203 (rank : 651)
Query Neighborhood Hits	524	Target Neighborhood Hits	84	Shared Neighborhood Hits	18
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRZ_HUMAN
θ value	θ > 10 (rank : 1087)	NC score	0.103782 (rank : 556)
Query Neighborhood Hits	524	Target Neighborhood Hits	255	Shared Neighborhood Hits	42
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PVRL2_MOUSE
θ value	θ > 10 (rank : 1088)	NC score	0.303699 (rank : 274)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	141
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

R4RL1_HUMAN
θ value	θ > 10 (rank : 1089)	NC score	0.068282 (rank : 728)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

R4RL1_MOUSE
θ value	θ > 10 (rank : 1090)	NC score	0.064812 (rank : 761)
Query Neighborhood Hits	524	Target Neighborhood Hits	235	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K0S5	Gene names	Rtn4rl1, Ngrl2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

R4RL2_HUMAN
θ value	θ > 10 (rank : 1091)	NC score	0.071452 (rank : 693)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	41
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

R4RL2_MOUSE
θ value	θ > 10 (rank : 1092)	NC score	0.071433 (rank : 694)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

RAF1_HUMAN
θ value	θ > 10 (rank : 1093)	NC score	0.089340 (rank : 595)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 1094)	NC score	0.090103 (rank : 593)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	84
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RET_HUMAN
θ value	θ > 10 (rank : 1095)	NC score	0.138097 (rank : 444)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 1096)	NC score	0.138918 (rank : 442)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	87
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIMB2_HUMAN
θ value	θ > 10 (rank : 1097)	NC score	0.145732 (rank : 429)
Query Neighborhood Hits	524	Target Neighborhood Hits	263	Shared Neighborhood Hits	61
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 1098)	NC score	0.134750 (rank : 450)
Query Neighborhood Hits	524	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIPK1_HUMAN
θ value	θ > 10 (rank : 1099)	NC score	0.087433 (rank : 603)
Query Neighborhood Hits	524	Target Neighborhood Hits	891	Shared Neighborhood Hits	84
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 1100)	NC score	0.088188 (rank : 600)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 1101)	NC score	0.078841 (rank : 655)
Query Neighborhood Hits	524	Target Neighborhood Hits	774	Shared Neighborhood Hits	81
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 1102)	NC score	0.082528 (rank : 624)
Query Neighborhood Hits	524	Target Neighborhood Hits	776	Shared Neighborhood Hits	82
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 1103)	NC score	0.083746 (rank : 616)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 1104)	NC score	0.064857 (rank : 760)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 1105)	NC score	0.060570 (rank : 843)
Query Neighborhood Hits	524	Target Neighborhood Hits	1094	Shared Neighborhood Hits	82
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 1106)	NC score	0.082767 (rank : 623)
Query Neighborhood Hits	524	Target Neighborhood Hits	864	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 1107)	NC score	0.082847 (rank : 622)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 1108)	NC score	0.125210 (rank : 469)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	82
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 1109)	NC score	0.127069 (rank : 462)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	82
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RTN4R_HUMAN
θ value	θ > 10 (rank : 1110)	NC score	0.069270 (rank : 711)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

RTN4R_MOUSE
θ value	θ > 10 (rank : 1111)	NC score	0.065906 (rank : 740)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

RXFP1_HUMAN
θ value	θ > 10 (rank : 1112)	NC score	0.054324 (rank : 1038)
Query Neighborhood Hits	524	Target Neighborhood Hits	816	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HBX9	Gene names	RXFP1, LGR7
Domain Architecture
Description	Relaxin receptor 1 (Relaxin family peptide receptor 1) (Leucine-rich repeat-containing G-protein coupled receptor 7).

RXFP2_HUMAN
θ value	θ > 10 (rank : 1113)	NC score	0.057509 (rank : 925)
Query Neighborhood Hits	524	Target Neighborhood Hits	736	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

RXFP2_MOUSE
θ value	θ > 10 (rank : 1114)	NC score	0.058561 (rank : 892)
Query Neighborhood Hits	524	Target Neighborhood Hits	760	Shared Neighborhood Hits	45
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

RYK_HUMAN
θ value	θ > 10 (rank : 1115)	NC score	0.148992 (rank : 427)
Query Neighborhood Hits	524	Target Neighborhood Hits	701	Shared Neighborhood Hits	81
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 1116)	NC score	0.147066 (rank : 428)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	80
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SCN4B_HUMAN
θ value	θ > 10 (rank : 1117)	NC score	0.055327 (rank : 989)
Query Neighborhood Hits	524	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWT1, Q6PIG5	Gene names	SCN4B
Domain Architecture	No domain graphic available
Description	Sodium channel beta-4 subunit precursor.

SCYL2_HUMAN
θ value	θ > 10 (rank : 1118)	NC score	0.050120 (rank : 1166)
Query Neighborhood Hits	524	Target Neighborhood Hits	632	Shared Neighborhood Hits	66
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1119)	NC score	0.051462 (rank : 1126)
Query Neighborhood Hits	524	Target Neighborhood Hits	603	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SIGL7_HUMAN
θ value	θ > 10 (rank : 1120)	NC score	0.255224 (rank : 324)
Query Neighborhood Hits	524	Target Neighborhood Hits	180	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

SIGL9_HUMAN
θ value	θ > 10 (rank : 1121)	NC score	0.109062 (rank : 540)
Query Neighborhood Hits	524	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

SIRPG_HUMAN
θ value	θ > 10 (rank : 1122)	NC score	0.117973 (rank : 491)
Query Neighborhood Hits	524	Target Neighborhood Hits	359	Shared Neighborhood Hits	110
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

SLAF5_HUMAN
θ value	θ > 10 (rank : 1123)	NC score	0.065542 (rank : 748)
Query Neighborhood Hits	524	Target Neighborhood Hits	65	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UIB8, O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1, Q8WWI8, Q9UF04, Q9UIB6, Q9UIB7, Q9UIT7	Gene names	CD84, SLAMF5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen) (Cell surface antigen MAX.3) (Hly9-beta).

SLAF5_MOUSE
θ value	θ > 10 (rank : 1124)	NC score	0.071950 (rank : 689)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	54
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

SLAF8_MOUSE
θ value	θ > 10 (rank : 1125)	NC score	0.073331 (rank : 682)
Query Neighborhood Hits	524	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D3G2, Q8R3T7	Gene names	Slamf8, Blame
Domain Architecture	No domain graphic available
Description	SLAM family member 8 precursor (B-lymphocyte activator macrophage expressed).

SLAF9_MOUSE
θ value	θ > 10 (rank : 1126)	NC score	0.078036 (rank : 660)
Query Neighborhood Hits	524	Target Neighborhood Hits	78	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D780, Q8BTK0, Q8VE93	Gene names	Slamf9
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor.

SLIK1_HUMAN
θ value	θ > 10 (rank : 1127)	NC score	0.050112 (rank : 1168)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PX8, Q5U5I6, Q96SF9	Gene names	SLITRK1, KIAA1910, LRRC12
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor (Leucine-rich repeat-containing protein 12).

SLIK1_MOUSE
θ value	θ > 10 (rank : 1128)	NC score	0.050066 (rank : 1171)
Query Neighborhood Hits	524	Target Neighborhood Hits	333	Shared Neighborhood Hits	42
SwissProt Accessions	Q810C1, Q9CXL0	Gene names	Slitrk1, Sltk1
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor.

SLIK3_HUMAN
θ value	θ > 10 (rank : 1129)	NC score	0.051673 (rank : 1119)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	42
SwissProt Accessions	O94933	Gene names	SLITRK3, KIAA0848
Domain Architecture	No domain graphic available
Description	SLIT and NTRK-like protein 3 precursor.

SLIK3_MOUSE
θ value	θ > 10 (rank : 1130)	NC score	0.051571 (rank : 1121)
Query Neighborhood Hits	524	Target Neighborhood Hits	308	Shared Neighborhood Hits	42
SwissProt Accessions	Q810B9	Gene names	Slitrk3
Domain Architecture
Description	SLIT and NTRK-like protein 3 precursor.

SLIK4_HUMAN
θ value	θ > 10 (rank : 1131)	NC score	0.050679 (rank : 1153)
Query Neighborhood Hits	524	Target Neighborhood Hits	287	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IW52, Q8TCM8, Q96DL3	Gene names	SLITRK4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

SLIK4_MOUSE
θ value	θ > 10 (rank : 1132)	NC score	0.050656 (rank : 1156)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	42
SwissProt Accessions	Q810B8, Q8BL56, Q8BWB0, Q8BYG4, Q8C056	Gene names	Slitrk4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

SLIK5_HUMAN
θ value	θ > 10 (rank : 1133)	NC score	0.051471 (rank : 1125)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	43
SwissProt Accessions	O94991	Gene names	SLITRK5, KIAA0918, LRRC11
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor (Leucine-rich repeat-containing protein 11).

SLIK5_MOUSE
θ value	θ > 10 (rank : 1134)	NC score	0.050709 (rank : 1152)
Query Neighborhood Hits	524	Target Neighborhood Hits	301	Shared Neighborhood Hits	43
SwissProt Accessions	Q810B7, Q9CT21	Gene names	Slitrk5
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor.

SLIK6_HUMAN
θ value	θ > 10 (rank : 1135)	NC score	0.055406 (rank : 986)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H5Y7, Q495Q0, Q6AW93, Q9HAA8, Q9NT60	Gene names	SLITRK6
Domain Architecture	No domain graphic available
Description	SLIT and NTRK-like protein 6 precursor.

SLIK6_MOUSE
θ value	θ > 10 (rank : 1136)	NC score	0.054883 (rank : 1007)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C110, Q8BLL0	Gene names	Slitrk6, Sltk6
Domain Architecture
Description	SLIT and NTRK-like protein 6 precursor.

SLIT1_HUMAN
θ value	θ > 10 (rank : 1137)	NC score	0.073664 (rank : 680)
Query Neighborhood Hits	524	Target Neighborhood Hits	700	Shared Neighborhood Hits	65
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SLIT1_MOUSE
θ value	θ > 10 (rank : 1138)	NC score	0.075727 (rank : 672)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	66
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

SLIT2_HUMAN
θ value	θ > 10 (rank : 1139)	NC score	0.077514 (rank : 662)
Query Neighborhood Hits	524	Target Neighborhood Hits	708	Shared Neighborhood Hits	67
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	θ > 10 (rank : 1140)	NC score	0.076741 (rank : 670)
Query Neighborhood Hits	524	Target Neighborhood Hits	684	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT3_HUMAN
θ value	θ > 10 (rank : 1141)	NC score	0.074629 (rank : 677)
Query Neighborhood Hits	524	Target Neighborhood Hits	682	Shared Neighborhood Hits	65
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

SLIT3_MOUSE
θ value	θ > 10 (rank : 1142)	NC score	0.074659 (rank : 676)
Query Neighborhood Hits	524	Target Neighborhood Hits	700	Shared Neighborhood Hits	65
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SLK_HUMAN
θ value	θ > 10 (rank : 1143)	NC score	0.056865 (rank : 940)
Query Neighborhood Hits	524	Target Neighborhood Hits	1775	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 1144)	NC score	0.056462 (rank : 952)
Query Neighborhood Hits	524	Target Neighborhood Hits	1798	Shared Neighborhood Hits	87
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SN1L1_HUMAN
θ value	θ > 10 (rank : 1145)	NC score	0.055814 (rank : 971)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	87
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 1146)	NC score	0.056606 (rank : 945)
Query Neighborhood Hits	524	Target Neighborhood Hits	895	Shared Neighborhood Hits	84
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 1147)	NC score	0.057693 (rank : 914)
Query Neighborhood Hits	524	Target Neighborhood Hits	964	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 1148)	NC score	0.057401 (rank : 929)
Query Neighborhood Hits	524	Target Neighborhood Hits	944	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SRC_HUMAN
θ value	θ > 10 (rank : 1149)	NC score	0.108427 (rank : 543)
Query Neighborhood Hits	524	Target Neighborhood Hits	1058	Shared Neighborhood Hits	84
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 1150)	NC score	0.109172 (rank : 539)
Query Neighborhood Hits	524	Target Neighborhood Hits	1033	Shared Neighborhood Hits	84
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SREC2_HUMAN
θ value	θ > 10 (rank : 1151)	NC score	0.052348 (rank : 1097)
Query Neighborhood Hits	524	Target Neighborhood Hits	645	Shared Neighborhood Hits	43
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SREC_HUMAN
θ value	θ > 10 (rank : 1152)	NC score	0.050721 (rank : 1150)
Query Neighborhood Hits	524	Target Neighborhood Hits	645	Shared Neighborhood Hits	37
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

SRMS_HUMAN
θ value	θ > 10 (rank : 1153)	NC score	0.119130 (rank : 488)
Query Neighborhood Hits	524	Target Neighborhood Hits	946	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 1154)	NC score	0.117884 (rank : 492)
Query Neighborhood Hits	524	Target Neighborhood Hits	964	Shared Neighborhood Hits	83
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ST17A_HUMAN
θ value	θ > 10 (rank : 1155)	NC score	0.060688 (rank : 839)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 1156)	NC score	0.060784 (rank : 836)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	79
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 1157)	NC score	0.065044 (rank : 755)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK10_HUMAN
θ value	θ > 10 (rank : 1158)	NC score	0.053392 (rank : 1073)
Query Neighborhood Hits	524	Target Neighborhood Hits	1921	Shared Neighborhood Hits	90
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 1159)	NC score	0.057410 (rank : 927)
Query Neighborhood Hits	524	Target Neighborhood Hits	831	Shared Neighborhood Hits	82
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK16_HUMAN
θ value	θ > 10 (rank : 1160)	NC score	0.057644 (rank : 918)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	81
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 1161)	NC score	0.057834 (rank : 910)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	81
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 1162)	NC score	0.068899 (rank : 720)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 1163)	NC score	0.068828 (rank : 721)
Query Neighborhood Hits	524	Target Neighborhood Hits	856	Shared Neighborhood Hits	83
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 1164)	NC score	0.065207 (rank : 753)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 1165)	NC score	0.065482 (rank : 749)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 1166)	NC score	0.062936 (rank : 788)
Query Neighborhood Hits	524	Target Neighborhood Hits	879	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 1167)	NC score	0.052705 (rank : 1092)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 1168)	NC score	0.061539 (rank : 816)
Query Neighborhood Hits	524	Target Neighborhood Hits	896	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 1169)	NC score	0.062547 (rank : 795)
Query Neighborhood Hits	524	Target Neighborhood Hits	877	Shared Neighborhood Hits	83
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK39_HUMAN
θ value	θ > 10 (rank : 1170)	NC score	0.061119 (rank : 827)
Query Neighborhood Hits	524	Target Neighborhood Hits	882	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 1171)	NC score	0.061333 (rank : 821)
Query Neighborhood Hits	524	Target Neighborhood Hits	915	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 1172)	NC score	0.063169 (rank : 784)
Query Neighborhood Hits	524	Target Neighborhood Hits	861	Shared Neighborhood Hits	83
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 1173)	NC score	0.063736 (rank : 777)
Query Neighborhood Hits	524	Target Neighborhood Hits	869	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 1174)	NC score	0.063878 (rank : 771)
Query Neighborhood Hits	524	Target Neighborhood Hits	870	Shared Neighborhood Hits	83
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 1175)	NC score	0.064158 (rank : 768)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 1176)	NC score	0.058639 (rank : 889)
Query Neighborhood Hits	524	Target Neighborhood Hits	916	Shared Neighborhood Hits	85
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 1177)	NC score	0.057407 (rank : 928)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STYK1_HUMAN
θ value	θ > 10 (rank : 1178)	NC score	0.138196 (rank : 443)
Query Neighborhood Hits	524	Target Neighborhood Hits	786	Shared Neighborhood Hits	85
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 1179)	NC score	0.140516 (rank : 440)
Query Neighborhood Hits	524	Target Neighborhood Hits	779	Shared Neighborhood Hits	84
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TACT_HUMAN
θ value	θ > 10 (rank : 1180)	NC score	0.051702 (rank : 1118)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

TAOK2_HUMAN
θ value	θ > 10 (rank : 1181)	NC score	0.055292 (rank : 990)
Query Neighborhood Hits	524	Target Neighborhood Hits	1172	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 1182)	NC score	0.052971 (rank : 1085)
Query Neighborhood Hits	524	Target Neighborhood Hits	1373	Shared Neighborhood Hits	85
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TBK1_HUMAN
θ value	θ > 10 (rank : 1183)	NC score	0.050990 (rank : 1139)
Query Neighborhood Hits	524	Target Neighborhood Hits	861	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 1184)	NC score	0.050570 (rank : 1160)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	80
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TEC_HUMAN
θ value	θ > 10 (rank : 1185)	NC score	0.111502 (rank : 521)
Query Neighborhood Hits	524	Target Neighborhood Hits	1006	Shared Neighborhood Hits	85
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 1186)	NC score	0.110999 (rank : 523)
Query Neighborhood Hits	524	Target Neighborhood Hits	1006	Shared Neighborhood Hits	83
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 1187)	NC score	0.083496 (rank : 617)
Query Neighborhood Hits	524	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 1188)	NC score	0.084329 (rank : 613)
Query Neighborhood Hits	524	Target Neighborhood Hits	862	Shared Neighborhood Hits	85
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 1189)	NC score	0.090214 (rank : 591)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 1190)	NC score	0.090115 (rank : 592)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 1191)	NC score	0.076902 (rank : 667)
Query Neighborhood Hits	524	Target Neighborhood Hits	1103	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1192)	NC score	0.076785 (rank : 668)
Query Neighborhood Hits	524	Target Neighborhood Hits	1333	Shared Neighborhood Hits	82
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 1193)	NC score	0.062969 (rank : 787)
Query Neighborhood Hits	524	Target Neighborhood Hits	755	Shared Neighborhood Hits	82
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 1194)	NC score	0.063190 (rank : 783)
Query Neighborhood Hits	524	Target Neighborhood Hits	753	Shared Neighborhood Hits	82
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 1195)	NC score	0.069246 (rank : 712)
Query Neighborhood Hits	524	Target Neighborhood Hits	748	Shared Neighborhood Hits	81
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 1196)	NC score	0.068319 (rank : 727)
Query Neighborhood Hits	524	Target Neighborhood Hits	748	Shared Neighborhood Hits	82
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TLR11_MOUSE
θ value	θ > 10 (rank : 1197)	NC score	0.052229 (rank : 1098)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	45
SwissProt Accessions	Q6R5P0	Gene names	Tlr11
Domain Architecture	No domain graphic available
Description	Toll-like receptor 11 precursor.

TLR13_MOUSE
θ value	θ > 10 (rank : 1198)	NC score	0.063746 (rank : 775)
Query Neighborhood Hits	524	Target Neighborhood Hits	335	Shared Neighborhood Hits	55
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

TLR3_HUMAN
θ value	θ > 10 (rank : 1199)	NC score	0.059627 (rank : 869)
Query Neighborhood Hits	524	Target Neighborhood Hits	323	Shared Neighborhood Hits	46
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

TLR3_MOUSE
θ value	θ > 10 (rank : 1200)	NC score	0.061028 (rank : 829)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	44
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

TLR4_HUMAN
θ value	θ > 10 (rank : 1201)	NC score	0.054977 (rank : 1005)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	50
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).

TLR4_MOUSE
θ value	θ > 10 (rank : 1202)	NC score	0.055480 (rank : 984)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QUK6, Q9D691, Q9QZF5, Q9Z203	Gene names	Tlr4, Lps
Domain Architecture
Description	Toll-like receptor 4 precursor (CD284 antigen).

TLR5_HUMAN
θ value	θ > 10 (rank : 1203)	NC score	0.061587 (rank : 814)
Query Neighborhood Hits	524	Target Neighborhood Hits	288	Shared Neighborhood Hits	48
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

TLR5_MOUSE
θ value	θ > 10 (rank : 1204)	NC score	0.058842 (rank : 882)
Query Neighborhood Hits	524	Target Neighborhood Hits	287	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

TLR7_HUMAN
θ value	θ > 10 (rank : 1205)	NC score	0.054745 (rank : 1014)
Query Neighborhood Hits	524	Target Neighborhood Hits	312	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYK1, Q9NR98	Gene names	TLR7
Domain Architecture
Description	Toll-like receptor 7 precursor.

TLR7_MOUSE
θ value	θ > 10 (rank : 1206)	NC score	0.051862 (rank : 1113)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	P58681, Q923I1	Gene names	Tlr7
Domain Architecture
Description	Toll-like receptor 7 precursor.

TLR8_HUMAN
θ value	θ > 10 (rank : 1207)	NC score	0.054652 (rank : 1022)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR97, Q6UXL6, Q9NYG9	Gene names	TLR8
Domain Architecture
Description	Toll-like receptor 8 precursor.

TLR8_MOUSE
θ value	θ > 10 (rank : 1208)	NC score	0.054742 (rank : 1016)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	49
SwissProt Accessions	P58682, Q91XI7	Gene names	Tlr8
Domain Architecture
Description	Toll-like receptor 8 precursor.

TLR9_HUMAN
θ value	θ > 10 (rank : 1209)	NC score	0.056197 (rank : 957)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR96, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3	Gene names	TLR9
Domain Architecture
Description	Toll-like receptor 9 precursor (CD289 antigen).

TMM25_HUMAN
θ value	θ > 10 (rank : 1210)	NC score	0.079757 (rank : 647)
Query Neighborhood Hits	524	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TMM25_MOUSE
θ value	θ > 10 (rank : 1211)	NC score	0.084759 (rank : 611)
Query Neighborhood Hits	524	Target Neighborhood Hits	46	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TNI3K_HUMAN
θ value	θ > 10 (rank : 1212)	NC score	0.071889 (rank : 691)
Query Neighborhood Hits	524	Target Neighborhood Hits	1084	Shared Neighborhood Hits	80
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 1213)	NC score	0.073028 (rank : 684)
Query Neighborhood Hits	524	Target Neighborhood Hits	1079	Shared Neighborhood Hits	81
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 1214)	NC score	0.054254 (rank : 1042)
Query Neighborhood Hits	524	Target Neighborhood Hits	1570	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TNK1_HUMAN
θ value	θ > 10 (rank : 1215)	NC score	0.128136 (rank : 460)
Query Neighborhood Hits	524	Target Neighborhood Hits	815	Shared Neighborhood Hits	83
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 1216)	NC score	0.125937 (rank : 465)
Query Neighborhood Hits	524	Target Neighborhood Hits	806	Shared Neighborhood Hits	86
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 1217)	NC score	0.080099 (rank : 640)
Query Neighborhood Hits	524	Target Neighborhood Hits	605	Shared Neighborhood Hits	73
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 1218)	NC score	0.081755 (rank : 627)
Query Neighborhood Hits	524	Target Neighborhood Hits	618	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TPBG_HUMAN
θ value	θ > 10 (rank : 1219)	NC score	0.065710 (rank : 745)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q13641	Gene names	TPBG, 5T4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (5T4 oncofetal antigen) (M6P1).

TPBG_MOUSE
θ value	θ > 10 (rank : 1220)	NC score	0.062471 (rank : 798)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0L0, Q6PE98, Q8BQA4	Gene names	Tpbg, 5t4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein).

TPSNR_HUMAN
θ value	θ > 10 (rank : 1221)	NC score	0.137245 (rank : 445)
Query Neighborhood Hits	524	Target Neighborhood Hits	330	Shared Neighborhood Hits	106
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

TRIM9_HUMAN
θ value	θ > 10 (rank : 1222)	NC score	0.069878 (rank : 705)
Query Neighborhood Hits	524	Target Neighborhood Hits	294	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

TSK_HUMAN
θ value	θ > 10 (rank : 1223)	NC score	0.070603 (rank : 700)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

TSK_MOUSE
θ value	θ > 10 (rank : 1224)	NC score	0.062503 (rank : 797)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

TSSK1_MOUSE
θ value	θ > 10 (rank : 1225)	NC score	0.052902 (rank : 1087)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	82
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 1226)	NC score	0.051506 (rank : 1123)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	81
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK4_MOUSE
θ value	θ > 10 (rank : 1227)	NC score	0.053395 (rank : 1072)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 1228)	NC score	0.053588 (rank : 1066)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 1229)	NC score	0.054007 (rank : 1048)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTK_HUMAN
θ value	θ > 10 (rank : 1230)	NC score	0.051350 (rank : 1129)
Query Neighborhood Hits	524	Target Neighborhood Hits	816	Shared Neighborhood Hits	78
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TXK_HUMAN
θ value	θ > 10 (rank : 1231)	NC score	0.112267 (rank : 512)
Query Neighborhood Hits	524	Target Neighborhood Hits	971	Shared Neighborhood Hits	84
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 1232)	NC score	0.113340 (rank : 505)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	84
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 1233)	NC score	0.106702 (rank : 551)
Query Neighborhood Hits	524	Target Neighborhood Hits	841	Shared Neighborhood Hits	83
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 1234)	NC score	0.107499 (rank : 549)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

UHMK1_HUMAN
θ value	θ > 10 (rank : 1235)	NC score	0.055236 (rank : 992)
Query Neighborhood Hits	524	Target Neighborhood Hits	808	Shared Neighborhood Hits	74
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	θ > 10 (rank : 1236)	NC score	0.055717 (rank : 977)
Query Neighborhood Hits	524	Target Neighborhood Hits	809	Shared Neighborhood Hits	75
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK1_HUMAN
θ value	θ > 10 (rank : 1237)	NC score	0.059899 (rank : 866)
Query Neighborhood Hits	524	Target Neighborhood Hits	1121	Shared Neighborhood Hits	87
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 1238)	NC score	0.059572 (rank : 872)
Query Neighborhood Hits	524	Target Neighborhood Hits	1214	Shared Neighborhood Hits	91
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 1239)	NC score	0.060525 (rank : 844)
Query Neighborhood Hits	524	Target Neighborhood Hits	979	Shared Neighborhood Hits	89
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 1240)	NC score	0.060258 (rank : 855)
Query Neighborhood Hits	524	Target Neighborhood Hits	943	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 1241)	NC score	0.063293 (rank : 782)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 1242)	NC score	0.063350 (rank : 781)
Query Neighborhood Hits	524	Target Neighborhood Hits	872	Shared Neighborhood Hits	83
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

VASN_HUMAN
θ value	θ > 10 (rank : 1243)	NC score	0.078361 (rank : 658)
Query Neighborhood Hits	524	Target Neighborhood Hits	449	Shared Neighborhood Hits	62
SwissProt Accessions	Q6EMK4, Q6UXL4, Q6UXL5, Q96CX1	Gene names	VASN, SLITL2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

VASN_MOUSE
θ value	θ > 10 (rank : 1244)	NC score	0.079578 (rank : 648)
Query Neighborhood Hits	524	Target Neighborhood Hits	426	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

WEE1_MOUSE
θ value	θ > 10 (rank : 1245)	NC score	0.051247 (rank : 1130)
Query Neighborhood Hits	524	Target Neighborhood Hits	794	Shared Neighborhood Hits	72
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

YES_HUMAN
θ value	θ > 10 (rank : 1246)	NC score	0.109016 (rank : 541)
Query Neighborhood Hits	524	Target Neighborhood Hits	1059	Shared Neighborhood Hits	85
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 1247)	NC score	0.108912 (rank : 542)
Query Neighborhood Hits	524	Target Neighborhood Hits	1052	Shared Neighborhood Hits	84
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YSK4_HUMAN
θ value	θ > 10 (rank : 1248)	NC score	0.068491 (rank : 725)
Query Neighborhood Hits	524	Target Neighborhood Hits	921	Shared Neighborhood Hits	83
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 1249)	NC score	0.119786 (rank : 487)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	83
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 1250)	NC score	0.121117 (rank : 480)
Query Neighborhood Hits	524	Target Neighborhood Hits	905	Shared Neighborhood Hits	83
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

DSCAM_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	524	Target Neighborhood Hits	524	Shared Neighborhood Hits	524
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
NC score	0.982940 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	524	Target Neighborhood Hits	589	Shared Neighborhood Hits	428
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

SDK2_HUMAN
NC score	0.934649 (rank : 3)	θ value	8.20983e-86 (rank : 3)
Query Neighborhood Hits	524	Target Neighborhood Hits	495	Shared Neighborhood Hits	397
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
NC score	0.933408 (rank : 4)	θ value	4.50487e-84 (rank : 4)
Query Neighborhood Hits	524	Target Neighborhood Hits	480	Shared Neighborhood Hits	395
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK1_MOUSE
NC score	0.931740 (rank : 5)	θ value	3.34088e-79 (rank : 5)
Query Neighborhood Hits	524	Target Neighborhood Hits	495	Shared Neighborhood Hits	389
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

DCC_HUMAN
NC score	0.931651 (rank : 6)	θ value	1.00825e-67 (rank : 8)
Query Neighborhood Hits	524	Target Neighborhood Hits	583	Shared Neighborhood Hits	410
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

SDK1_HUMAN
NC score	0.931640 (rank : 7)	θ value	9.7205e-79 (rank : 6)
Query Neighborhood Hits	524	Target Neighborhood Hits	511	Shared Neighborhood Hits	388
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

NEO1_HUMAN
NC score	0.929122 (rank : 8)	θ value	3.03575e-64 (rank : 10)
Query Neighborhood Hits	524	Target Neighborhood Hits	530	Shared Neighborhood Hits	394
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
NC score	0.927023 (rank : 9)	θ value	2.56992e-63 (rank : 11)
Query Neighborhood Hits	524	Target Neighborhood Hits	523	Shared Neighborhood Hits	393
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NFASC_HUMAN
NC score	0.924806 (rank : 10)	θ value	1.15626e-55 (rank : 24)
Query Neighborhood Hits	524	Target Neighborhood Hits	497	Shared Neighborhood Hits	391
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NRCAM_MOUSE
NC score	0.924631 (rank : 11)	θ value	4.69435e-57 (rank : 18)
Query Neighborhood Hits	524	Target Neighborhood Hits	432	Shared Neighborhood Hits	371
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

L1CAM_MOUSE
NC score	0.923695 (rank : 12)	θ value	7.73779e-60 (rank : 16)
Query Neighborhood Hits	524	Target Neighborhood Hits	457	Shared Neighborhood Hits	396
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NRCAM_HUMAN
NC score	0.922692 (rank : 13)	θ value	3.48141e-52 (rank : 34)
Query Neighborhood Hits	524	Target Neighborhood Hits	439	Shared Neighborhood Hits	385
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

L1CAM_HUMAN
NC score	0.921333 (rank : 14)	θ value	1.41016e-61 (rank : 13)
Query Neighborhood Hits	524	Target Neighborhood Hits	457	Shared Neighborhood Hits	392
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN2_MOUSE
NC score	0.921027 (rank : 15)	θ value	2.57589e-55 (rank : 26)
Query Neighborhood Hits	524	Target Neighborhood Hits	450	Shared Neighborhood Hits	400
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_HUMAN
NC score	0.920322 (rank : 16)	θ value	1.19655e-52 (rank : 33)
Query Neighborhood Hits	524	Target Neighborhood Hits	440	Shared Neighborhood Hits	389
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN5_HUMAN
NC score	0.918412 (rank : 17)	θ value	3.0428e-56 (rank : 22)
Query Neighborhood Hits	524	Target Neighborhood Hits	446	Shared Neighborhood Hits	390
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

NFASC_MOUSE
NC score	0.917891 (rank : 18)	θ value	1.57e-36 (rank : 44)
Query Neighborhood Hits	524	Target Neighborhood Hits	475	Shared Neighborhood Hits	383
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

ROBO2_HUMAN
NC score	0.917730 (rank : 19)	θ value	1.36585e-56 (rank : 20)
Query Neighborhood Hits	524	Target Neighborhood Hits	479	Shared Neighborhood Hits	398
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

CNTN3_HUMAN
NC score	0.917119 (rank : 20)	θ value	2.32979e-56 (rank : 21)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	399
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

ROBO2_MOUSE
NC score	0.917004 (rank : 21)	θ value	6.77864e-56 (rank : 23)
Query Neighborhood Hits	524	Target Neighborhood Hits	504	Shared Neighborhood Hits	403
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

CNTN5_MOUSE
NC score	0.916170 (rank : 22)	θ value	1.0458e-56 (rank : 19)
Query Neighborhood Hits	524	Target Neighborhood Hits	434	Shared Neighborhood Hits	382
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

ROBO3_HUMAN
NC score	0.916156 (rank : 23)	θ value	6.56568e-51 (rank : 35)
Query Neighborhood Hits	524	Target Neighborhood Hits	570	Shared Neighborhood Hits	396
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

CHL1_HUMAN
NC score	0.914681 (rank : 24)	θ value	5.73848e-55 (rank : 28)
Query Neighborhood Hits	524	Target Neighborhood Hits	413	Shared Neighborhood Hits	363
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CNTN1_HUMAN
NC score	0.914445 (rank : 25)	θ value	5.73848e-55 (rank : 29)
Query Neighborhood Hits	524	Target Neighborhood Hits	431	Shared Neighborhood Hits	373
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
NC score	0.914417 (rank : 26)	θ value	2.41096e-53 (rank : 32)
Query Neighborhood Hits	524	Target Neighborhood Hits	422	Shared Neighborhood Hits	373
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN4_HUMAN
NC score	0.914270 (rank : 27)	θ value	1.97229e-55 (rank : 25)
Query Neighborhood Hits	524	Target Neighborhood Hits	449	Shared Neighborhood Hits	386
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN3_MOUSE
NC score	0.913689 (rank : 28)	θ value	1.61343e-57 (rank : 17)
Query Neighborhood Hits	524	Target Neighborhood Hits	447	Shared Neighborhood Hits	388
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

DCC_MOUSE
NC score	0.913626 (rank : 29)	θ value	5.34618e-69 (rank : 7)
Query Neighborhood Hits	524	Target Neighborhood Hits	896	Shared Neighborhood Hits	414
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

CNTN4_MOUSE
NC score	0.913556 (rank : 30)	θ value	4.39379e-55 (rank : 27)
Query Neighborhood Hits	524	Target Neighborhood Hits	445	Shared Neighborhood Hits	381
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

ROBO1_MOUSE
NC score	0.912974 (rank : 31)	θ value	1.19377e-60 (rank : 14)
Query Neighborhood Hits	524	Target Neighborhood Hits	559	Shared Neighborhood Hits	401
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO3_MOUSE
NC score	0.911484 (rank : 32)	θ value	1.73182e-43 (rank : 41)
Query Neighborhood Hits	524	Target Neighborhood Hits	524	Shared Neighborhood Hits	377
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

PUNC_HUMAN
NC score	0.910933 (rank : 33)	θ value	2.59387e-31 (rank : 52)
Query Neighborhood Hits	524	Target Neighborhood Hits	449	Shared Neighborhood Hits	360
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ROBO1_HUMAN
NC score	0.910060 (rank : 34)	θ value	4.53632e-60 (rank : 15)
Query Neighborhood Hits	524	Target Neighborhood Hits	529	Shared Neighborhood Hits	394
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

CHL1_MOUSE
NC score	0.909459 (rank : 35)	θ value	7.25919e-50 (rank : 37)
Query Neighborhood Hits	524	Target Neighborhood Hits	402	Shared Neighborhood Hits	359
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CNTN6_HUMAN
NC score	0.908702 (rank : 36)	θ value	9.48078e-50 (rank : 38)
Query Neighborhood Hits	524	Target Neighborhood Hits	422	Shared Neighborhood Hits	375
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN6_MOUSE
NC score	0.908594 (rank : 37)	θ value	1.2784e-54 (rank : 30)
Query Neighborhood Hits	524	Target Neighborhood Hits	429	Shared Neighborhood Hits	374
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

PUNC_MOUSE
NC score	0.907911 (rank : 38)	θ value	2.34606e-32 (rank : 48)
Query Neighborhood Hits	524	Target Neighborhood Hits	501	Shared Neighborhood Hits	355
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

NCAM2_MOUSE
NC score	0.893208 (rank : 39)	θ value	9.8567e-31 (rank : 53)
Query Neighborhood Hits	524	Target Neighborhood Hits	472	Shared Neighborhood Hits	397
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCAM2_HUMAN
NC score	0.888457 (rank : 40)	θ value	1.12514e-34 (rank : 46)
Query Neighborhood Hits	524	Target Neighborhood Hits	441	Shared Neighborhood Hits	391
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

CDON_MOUSE
NC score	0.872893 (rank : 41)	θ value	4.43474e-23 (rank : 58)
Query Neighborhood Hits	524	Target Neighborhood Hits	410	Shared Neighborhood Hits	340
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_HUMAN
NC score	0.871115 (rank : 42)	θ value	1.86321e-21 (rank : 65)
Query Neighborhood Hits	524	Target Neighborhood Hits	412	Shared Neighborhood Hits	332
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

NCA11_HUMAN
NC score	0.870908 (rank : 43)	θ value	9.52487e-34 (rank : 47)
Query Neighborhood Hits	524	Target Neighborhood Hits	443	Shared Neighborhood Hits	375
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

BOC_HUMAN
NC score	0.870036 (rank : 44)	θ value	4.74913e-17 (rank : 79)
Query Neighborhood Hits	524	Target Neighborhood Hits	543	Shared Neighborhood Hits	360
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BOC_MOUSE
NC score	0.867960 (rank : 45)	θ value	1.058e-16 (rank : 86)
Query Neighborhood Hits	524	Target Neighborhood Hits	433	Shared Neighborhood Hits	347
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCA12_HUMAN
NC score	0.865807 (rank : 46)	θ value	2.59387e-31 (rank : 51)
Query Neighborhood Hits	524	Target Neighborhood Hits	437	Shared Neighborhood Hits	371
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA12_MOUSE
NC score	0.865283 (rank : 47)	θ value	1.98606e-31 (rank : 50)
Query Neighborhood Hits	524	Target Neighborhood Hits	399	Shared Neighborhood Hits	360
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCA11_MOUSE
NC score	0.850166 (rank : 48)	θ value	1.16434e-31 (rank : 49)
Query Neighborhood Hits	524	Target Neighborhood Hits	661	Shared Neighborhood Hits	378
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

OBSL1_HUMAN
NC score	0.826461 (rank : 49)	θ value	1.42992e-13 (rank : 108)
Query Neighborhood Hits	524	Target Neighborhood Hits	354	Shared Neighborhood Hits	293
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

MAMC1_HUMAN
NC score	0.812661 (rank : 50)	θ value	9.87957e-23 (rank : 59)
Query Neighborhood Hits	524	Target Neighborhood Hits	357	Shared Neighborhood Hits	304
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

ROBO4_MOUSE
NC score	0.811748 (rank : 51)	θ value	4.02038e-16 (rank : 91)
Query Neighborhood Hits	524	Target Neighborhood Hits	358	Shared Neighborhood Hits	283
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MAMC1_MOUSE
NC score	0.811052 (rank : 52)	θ value	1.29031e-22 (rank : 61)
Query Neighborhood Hits	524	Target Neighborhood Hits	357	Shared Neighborhood Hits	302
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

ROBO4_HUMAN
NC score	0.809339 (rank : 53)	θ value	3.63628e-17 (rank : 78)
Query Neighborhood Hits	524	Target Neighborhood Hits	364	Shared Neighborhood Hits	274
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

NPHN_HUMAN
NC score	0.808651 (rank : 54)	θ value	3.17815e-21 (rank : 66)
Query Neighborhood Hits	524	Target Neighborhood Hits	362	Shared Neighborhood Hits	308
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

LSAMP_MOUSE
NC score	0.805833 (rank : 55)	θ value	1.52774e-15 (rank : 96)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	307
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

LSAMP_HUMAN
NC score	0.804831 (rank : 56)	θ value	1.16975e-15 (rank : 95)
Query Neighborhood Hits	524	Target Neighborhood Hits	347	Shared Neighborhood Hits	309
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

FGRL1_HUMAN
NC score	0.803931 (rank : 57)	θ value	6.00763e-12 (rank : 124)
Query Neighborhood Hits	524	Target Neighborhood Hits	335	Shared Neighborhood Hits	285
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

MYPN_HUMAN
NC score	0.800128 (rank : 58)	θ value	6.20254e-17 (rank : 82)
Query Neighborhood Hits	524	Target Neighborhood Hits	418	Shared Neighborhood Hits	287
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MDGA1_HUMAN
NC score	0.798505 (rank : 59)	θ value	1.16704e-23 (rank : 57)
Query Neighborhood Hits	524	Target Neighborhood Hits	358	Shared Neighborhood Hits	293
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

FGRL1_MOUSE
NC score	0.798389 (rank : 60)	θ value	2.28291e-11 (rank : 134)
Query Neighborhood Hits	524	Target Neighborhood Hits	325	Shared Neighborhood Hits	288
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

MYOTI_HUMAN
NC score	0.797147 (rank : 61)	θ value	3.64472e-09 (rank : 153)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	265
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
NC score	0.797092 (rank : 62)	θ value	4.76016e-09 (rank : 155)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	259
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

OPCM_HUMAN
NC score	0.795612 (rank : 63)	θ value	2.60593e-15 (rank : 99)
Query Neighborhood Hits	524	Target Neighborhood Hits	332	Shared Neighborhood Hits	306
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

NPHN_MOUSE
NC score	0.793033 (rank : 64)	θ value	1.02238e-19 (rank : 70)
Query Neighborhood Hits	524	Target Neighborhood Hits	370	Shared Neighborhood Hits	309
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NEGR1_HUMAN
NC score	0.792509 (rank : 65)	θ value	4.59992e-12 (rank : 123)
Query Neighborhood Hits	524	Target Neighborhood Hits	346	Shared Neighborhood Hits	304
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

NTRI_MOUSE
NC score	0.791984 (rank : 66)	θ value	2.35696e-16 (rank : 89)
Query Neighborhood Hits	524	Target Neighborhood Hits	342	Shared Neighborhood Hits	312
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

MYPN_MOUSE
NC score	0.789978 (rank : 67)	θ value	3.07829e-16 (rank : 90)
Query Neighborhood Hits	524	Target Neighborhood Hits	421	Shared Neighborhood Hits	287
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NEGR1_MOUSE
NC score	0.789377 (rank : 68)	θ value	3.52202e-12 (rank : 122)
Query Neighborhood Hits	524	Target Neighborhood Hits	349	Shared Neighborhood Hits	303
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NTRI_HUMAN
NC score	0.788900 (rank : 69)	θ value	5.25075e-16 (rank : 93)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	313
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

VCAM1_MOUSE
NC score	0.760892 (rank : 70)	θ value	1.09485e-13 (rank : 107)
Query Neighborhood Hits	524	Target Neighborhood Hits	320	Shared Neighborhood Hits	272
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

MYOM2_HUMAN
NC score	0.759179 (rank : 71)	θ value	3.40345e-15 (rank : 100)
Query Neighborhood Hits	524	Target Neighborhood Hits	341	Shared Neighborhood Hits	299
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

VCAM1_HUMAN
NC score	0.754242 (rank : 72)	θ value	3.76295e-14 (rank : 104)
Query Neighborhood Hits	524	Target Neighborhood Hits	352	Shared Neighborhood Hits	274
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

MYOM1_HUMAN
NC score	0.748680 (rank : 73)	θ value	3.18553e-13 (rank : 110)
Query Neighborhood Hits	524	Target Neighborhood Hits	405	Shared Neighborhood Hits	306
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
NC score	0.737469 (rank : 74)	θ value	1.17247e-07 (rank : 185)
Query Neighborhood Hits	524	Target Neighborhood Hits	415	Shared Neighborhood Hits	318
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

KIRR2_HUMAN
NC score	0.727914 (rank : 75)	θ value	7.84624e-12 (rank : 126)
Query Neighborhood Hits	524	Target Neighborhood Hits	321	Shared Neighborhood Hits	255
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

KIRR2_MOUSE
NC score	0.724598 (rank : 76)	θ value	1.02475e-11 (rank : 130)
Query Neighborhood Hits	524	Target Neighborhood Hits	326	Shared Neighborhood Hits	254
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

LU_HUMAN
NC score	0.720867 (rank : 77)	θ value	8.97725e-08 (rank : 183)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	257
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

SN_MOUSE
NC score	0.720434 (rank : 78)	θ value	1.99529e-15 (rank : 98)
Query Neighborhood Hits	524	Target Neighborhood Hits	416	Shared Neighborhood Hits	300
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

PTPRD_MOUSE
NC score	0.719456 (rank : 79)	θ value	4.40402e-47 (rank : 39)
Query Neighborhood Hits	524	Target Neighborhood Hits	491	Shared Neighborhood Hits	358
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
NC score	0.717272 (rank : 80)	θ value	5.55816e-50 (rank : 36)
Query Neighborhood Hits	524	Target Neighborhood Hits	489	Shared Neighborhood Hits	367
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

MYPC1_HUMAN
NC score	0.714874 (rank : 81)	θ value	8.10077e-17 (rank : 85)
Query Neighborhood Hits	524	Target Neighborhood Hits	303	Shared Neighborhood Hits	277
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

SN_HUMAN
NC score	0.714392 (rank : 82)	θ value	9.26847e-13 (rank : 116)
Query Neighborhood Hits	524	Target Neighborhood Hits	434	Shared Neighborhood Hits	302
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

MAG_MOUSE
NC score	0.713672 (rank : 83)	θ value	1.99992e-07 (rank : 194)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	249
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_HUMAN
NC score	0.712415 (rank : 84)	θ value	5.81887e-07 (rank : 201)
Query Neighborhood Hits	524	Target Neighborhood Hits	278	Shared Neighborhood Hits	252
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

CD22_MOUSE
NC score	0.710072 (rank : 85)	θ value	4.0297e-08 (rank : 173)
Query Neighborhood Hits	524	Target Neighborhood Hits	331	Shared Neighborhood Hits	253
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

MYPC2_HUMAN
NC score	0.709505 (rank : 86)	θ value	3.51386e-20 (rank : 69)
Query Neighborhood Hits	524	Target Neighborhood Hits	316	Shared Neighborhood Hits	280
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC2_MOUSE
NC score	0.707852 (rank : 87)	θ value	1.13037e-18 (rank : 74)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	267
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

PTPRD_HUMAN
NC score	0.705179 (rank : 88)	θ value	4.85792e-54 (rank : 31)
Query Neighborhood Hits	524	Target Neighborhood Hits	485	Shared Neighborhood Hits	350
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

FSTL4_HUMAN
NC score	0.704019 (rank : 89)	θ value	3.76295e-14 (rank : 103)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	268
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

CD22_HUMAN
NC score	0.701867 (rank : 90)	θ value	1.38499e-08 (rank : 161)
Query Neighborhood Hits	524	Target Neighborhood Hits	365	Shared Neighborhood Hits	268
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

MALT1_HUMAN
NC score	0.700527 (rank : 91)	θ value	1.69304e-06 (rank : 215)
Query Neighborhood Hits	524	Target Neighborhood Hits	236	Shared Neighborhood Hits	215
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

FSTL5_HUMAN
NC score	0.698603 (rank : 92)	θ value	1.9326e-10 (rank : 139)
Query Neighborhood Hits	524	Target Neighborhood Hits	347	Shared Neighborhood Hits	266
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL4_MOUSE
NC score	0.698071 (rank : 93)	θ value	1.99529e-15 (rank : 97)
Query Neighborhood Hits	524	Target Neighborhood Hits	333	Shared Neighborhood Hits	261
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

PTPRS_HUMAN
NC score	0.697745 (rank : 94)	θ value	4.86918e-46 (rank : 40)
Query Neighborhood Hits	524	Target Neighborhood Hits	472	Shared Neighborhood Hits	347
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

MUC18_HUMAN
NC score	0.697663 (rank : 95)	θ value	7.84624e-12 (rank : 127)
Query Neighborhood Hits	524	Target Neighborhood Hits	275	Shared Neighborhood Hits	236
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

TMIGD_HUMAN
NC score	0.693853 (rank : 96)	θ value	5.26297e-08 (rank : 180)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	221
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

KIRR3_HUMAN
NC score	0.693570 (rank : 97)	θ value	4.74913e-17 (rank : 80)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	255
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

FSTL5_MOUSE
NC score	0.693477 (rank : 98)	θ value	5.08577e-11 (rank : 135)
Query Neighborhood Hits	524	Target Neighborhood Hits	355	Shared Neighborhood Hits	260
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

RAGE_HUMAN
NC score	0.693256 (rank : 99)	θ value	0.00102713 (rank : 304)
Query Neighborhood Hits	524	Target Neighborhood Hits	269	Shared Neighborhood Hits	245
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

JAM1_HUMAN
NC score	0.691051 (rank : 100)	θ value	6.21693e-09 (rank : 156)
Query Neighborhood Hits	524	Target Neighborhood Hits	294	Shared Neighborhood Hits	263
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

KIRR1_HUMAN
NC score	0.685955 (rank : 101)	θ value	2.0648e-12 (rank : 119)
Query Neighborhood Hits	524	Target Neighborhood Hits	401	Shared Neighborhood Hits	275
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KIRR3_MOUSE
NC score	0.685936 (rank : 102)	θ value	2.35696e-16 (rank : 87)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	246
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

KIRR1_MOUSE
NC score	0.683643 (rank : 103)	θ value	3.52202e-12 (rank : 121)
Query Neighborhood Hits	524	Target Neighborhood Hits	403	Shared Neighborhood Hits	275
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

MYPC3_HUMAN
NC score	0.683275 (rank : 104)	θ value	3.18553e-13 (rank : 111)
Query Neighborhood Hits	524	Target Neighborhood Hits	318	Shared Neighborhood Hits	272
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MUC18_MOUSE
NC score	0.683174 (rank : 105)	θ value	2.36244e-08 (rank : 168)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	238
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

ICAM5_MOUSE
NC score	0.681239 (rank : 106)	θ value	1.53129e-07 (rank : 190)
Query Neighborhood Hits	524	Target Neighborhood Hits	308	Shared Neighborhood Hits	253
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

MYPC3_MOUSE
NC score	0.680508 (rank : 107)	θ value	6.41864e-14 (rank : 106)
Query Neighborhood Hits	524	Target Neighborhood Hits	310	Shared Neighborhood Hits	272
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

CEAM5_HUMAN
NC score	0.679944 (rank : 108)	θ value	5.25075e-16 (rank : 92)
Query Neighborhood Hits	524	Target Neighborhood Hits	343	Shared Neighborhood Hits	284
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

TMIGD_MOUSE
NC score	0.675920 (rank : 109)	θ value	2.69671e-12 (rank : 120)
Query Neighborhood Hits	524	Target Neighborhood Hits	234	Shared Neighborhood Hits	224
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

JAM3_MOUSE
NC score	0.667107 (rank : 110)	θ value	8.40245e-06 (rank : 233)
Query Neighborhood Hits	524	Target Neighborhood Hits	286	Shared Neighborhood Hits	250
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

JAM1_MOUSE
NC score	0.663298 (rank : 111)	θ value	5.26297e-08 (rank : 177)
Query Neighborhood Hits	524	Target Neighborhood Hits	287	Shared Neighborhood Hits	256
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

JAM3_HUMAN
NC score	0.660889 (rank : 112)	θ value	0.00035302 (rank : 283)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	243
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

ICAM5_HUMAN
NC score	0.659348 (rank : 113)	θ value	6.43352e-06 (rank : 232)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	243
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

RAGE_MOUSE
NC score	0.657858 (rank : 114)	θ value	9.29e-05 (rank : 263)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	226
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

CEAM1_MOUSE
NC score	0.657701 (rank : 115)	θ value	1.2105e-12 (rank : 117)
Query Neighborhood Hits	524	Target Neighborhood Hits	326	Shared Neighborhood Hits	273
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

FNDC3_HUMAN
NC score	0.654961 (rank : 116)	θ value	3.76295e-14 (rank : 102)
Query Neighborhood Hits	524	Target Neighborhood Hits	196	Shared Neighborhood Hits	155
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

IGS4B_MOUSE
NC score	0.654921 (rank : 117)	θ value	5.26297e-08 (rank : 176)
Query Neighborhood Hits	524	Target Neighborhood Hits	328	Shared Neighborhood Hits	269
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

PGBM_HUMAN
NC score	0.654513 (rank : 118)	θ value	5.57106e-42 (rank : 42)
Query Neighborhood Hits	524	Target Neighborhood Hits	1113	Shared Neighborhood Hits	380
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

FNDC3_MOUSE
NC score	0.653714 (rank : 119)	θ value	1.74796e-11 (rank : 132)
Query Neighborhood Hits	524	Target Neighborhood Hits	207	Shared Neighborhood Hits	159
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

NPTN_HUMAN
NC score	0.651018 (rank : 120)	θ value	2.88788e-06 (rank : 224)
Query Neighborhood Hits	524	Target Neighborhood Hits	212	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

HMCN1_HUMAN
NC score	0.649690 (rank : 121)	θ value	3.35642e-63 (rank : 12)
Query Neighborhood Hits	524	Target Neighborhood Hits	983	Shared Neighborhood Hits	392
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

JAM2_HUMAN
NC score	0.647132 (rank : 122)	θ value	0.00175202 (rank : 310)
Query Neighborhood Hits	524	Target Neighborhood Hits	304	Shared Neighborhood Hits	275
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

IGS4B_HUMAN
NC score	0.642333 (rank : 123)	θ value	9.92553e-07 (rank : 205)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	257
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

NPTN_MOUSE
NC score	0.638970 (rank : 124)	θ value	0.00102713 (rank : 303)
Query Neighborhood Hits	524	Target Neighborhood Hits	216	Shared Neighborhood Hits	206
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

PGBM_MOUSE
NC score	0.638432 (rank : 125)	θ value	1.73584e-35 (rank : 45)
Query Neighborhood Hits	524	Target Neighborhood Hits	1073	Shared Neighborhood Hits	373
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

FCRL5_HUMAN
NC score	0.634326 (rank : 126)	θ value	4.16044e-13 (rank : 114)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	226
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

CEA20_HUMAN
NC score	0.632427 (rank : 127)	θ value	9.92553e-07 (rank : 204)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	213
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

JAM2_MOUSE
NC score	0.630518 (rank : 128)	θ value	0.000270298 (rank : 281)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	262
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

LRIG1_HUMAN
NC score	0.626784 (rank : 129)	θ value	1.33526e-19 (rank : 71)
Query Neighborhood Hits	524	Target Neighborhood Hits	654	Shared Neighborhood Hits	331
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYBPH_MOUSE
NC score	0.623590 (rank : 130)	θ value	1.06045e-08 (rank : 160)
Query Neighborhood Hits	524	Target Neighborhood Hits	290	Shared Neighborhood Hits	233
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

VSIG2_HUMAN
NC score	0.622862 (rank : 131)	θ value	2.44474e-05 (rank : 250)
Query Neighborhood Hits	524	Target Neighborhood Hits	321	Shared Neighborhood Hits	253
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

LRIG2_HUMAN
NC score	0.620371 (rank : 132)	θ value	6.40375e-22 (rank : 63)
Query Neighborhood Hits	524	Target Neighborhood Hits	595	Shared Neighborhood Hits	313
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

LRIG2_MOUSE
NC score	0.617989 (rank : 133)	θ value	8.36355e-22 (rank : 64)
Query Neighborhood Hits	524	Target Neighborhood Hits	586	Shared Neighborhood Hits	314
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

LRIG1_MOUSE
NC score	0.611220 (rank : 134)	θ value	2.35696e-16 (rank : 88)
Query Neighborhood Hits	524	Target Neighborhood Hits	627	Shared Neighborhood Hits	324
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYBPH_HUMAN
NC score	0.610038 (rank : 135)	θ value	9.29e-05 (rank : 262)
Query Neighborhood Hits	524	Target Neighborhood Hits	256	Shared Neighborhood Hits	226
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

BASI_HUMAN
NC score	0.608870 (rank : 136)	θ value	1.80886e-08 (rank : 165)
Query Neighborhood Hits	524	Target Neighborhood Hits	211	Shared Neighborhood Hits	198
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

CEAM1_HUMAN
NC score	0.608834 (rank : 137)	θ value	8.11959e-09 (rank : 157)
Query Neighborhood Hits	524	Target Neighborhood Hits	348	Shared Neighborhood Hits	269
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

VSIG2_MOUSE
NC score	0.607668 (rank : 138)	θ value	1.87187e-05 (rank : 243)
Query Neighborhood Hits	524	Target Neighborhood Hits	316	Shared Neighborhood Hits	244
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

BASI_MOUSE
NC score	0.598839 (rank : 139)	θ value	2.61198e-07 (rank : 196)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	208
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

LRIG3_MOUSE
NC score	0.596054 (rank : 140)	θ value	2.27762e-19 (rank : 72)
Query Neighborhood Hits	524	Target Neighborhood Hits	611	Shared Neighborhood Hits	320
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

FCRL2_HUMAN
NC score	0.590020 (rank : 141)	θ value	0.00020696 (rank : 276)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	208
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

LRIG3_HUMAN
NC score	0.589205 (rank : 142)	θ value	1.92812e-18 (rank : 75)
Query Neighborhood Hits	524	Target Neighborhood Hits	601	Shared Neighborhood Hits	317
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

SIG11_HUMAN
NC score	0.587043 (rank : 143)	θ value	8.40245e-06 (rank : 234)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	247
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

SIG10_HUMAN
NC score	0.579822 (rank : 144)	θ value	1.29631e-06 (rank : 212)
Query Neighborhood Hits	524	Target Neighborhood Hits	363	Shared Neighborhood Hits	237
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

KAZD1_MOUSE
NC score	0.578942 (rank : 145)	θ value	2.44474e-05 (rank : 247)
Query Neighborhood Hits	524	Target Neighborhood Hits	281	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

CI094_HUMAN
NC score	0.577074 (rank : 146)	θ value	1.99992e-07 (rank : 193)
Query Neighborhood Hits	524	Target Neighborhood Hits	310	Shared Neighborhood Hits	235
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

TITIN_HUMAN
NC score	0.573024 (rank : 147)	θ value	1.11475e-66 (rank : 9)
Query Neighborhood Hits	524	Target Neighborhood Hits	2923	Shared Neighborhood Hits	473
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CD166_MOUSE
NC score	0.558549 (rank : 148)	θ value	1.09739e-05 (rank : 235)
Query Neighborhood Hits	524	Target Neighborhood Hits	252	Shared Neighborhood Hits	209
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

GPA33_MOUSE
NC score	0.555568 (rank : 149)	θ value	1.80886e-08 (rank : 166)
Query Neighborhood Hits	524	Target Neighborhood Hits	294	Shared Neighborhood Hits	219
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

MFA3L_HUMAN
NC score	0.552865 (rank : 150)	θ value	0.00102713 (rank : 301)
Query Neighborhood Hits	524	Target Neighborhood Hits	230	Shared Neighborhood Hits	209
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

CEAM6_HUMAN
NC score	0.548555 (rank : 151)	θ value	2.44474e-05 (rank : 245)
Query Neighborhood Hits	524	Target Neighborhood Hits	308	Shared Neighborhood Hits	263
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

NRG2_HUMAN
NC score	0.546891 (rank : 152)	θ value	9.92553e-07 (rank : 207)
Query Neighborhood Hits	524	Target Neighborhood Hits	419	Shared Neighborhood Hits	242
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

VSIG4_HUMAN
NC score	0.546402 (rank : 153)	θ value	0.00102713 (rank : 305)
Query Neighborhood Hits	524	Target Neighborhood Hits	236	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

NRG2_MOUSE
NC score	0.539124 (rank : 154)	θ value	1.69304e-06 (rank : 216)
Query Neighborhood Hits	524	Target Neighborhood Hits	392	Shared Neighborhood Hits	242
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

KAZD1_HUMAN
NC score	0.533831 (rank : 155)	θ value	0.000121331 (rank : 268)
Query Neighborhood Hits	524	Target Neighborhood Hits	248	Shared Neighborhood Hits	172
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

CD166_HUMAN
NC score	0.531929 (rank : 156)	θ value	2.44474e-05 (rank : 244)
Query Neighborhood Hits	524	Target Neighborhood Hits	247	Shared Neighborhood Hits	200
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

FINC_MOUSE
NC score	0.528429 (rank : 157)	θ value	3.75424e-22 (rank : 62)
Query Neighborhood Hits	524	Target Neighborhood Hits	309	Shared Neighborhood Hits	165
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

GPA33_HUMAN
NC score	0.527028 (rank : 158)	θ value	1.53129e-07 (rank : 188)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	215
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

FINC_HUMAN
NC score	0.517217 (rank : 159)	θ value	8.10077e-17 (rank : 83)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	171
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

PTK7_HUMAN
NC score	0.516655 (rank : 160)	θ value	8.32485e-38 (rank : 43)
Query Neighborhood Hits	524	Target Neighborhood Hits	1103	Shared Neighborhood Hits	358
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

IBP7_HUMAN
NC score	0.504093 (rank : 161)	θ value	0.00134147 (rank : 306)
Query Neighborhood Hits	524	Target Neighborhood Hits	220	Shared Neighborhood Hits	165
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

CEAM8_HUMAN
NC score	0.489491 (rank : 162)	θ value	0.000461057 (rank : 288)
Query Neighborhood Hits	524	Target Neighborhood Hits	264	Shared Neighborhood Hits	233
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

IBP7_MOUSE
NC score	0.487492 (rank : 163)	θ value	0.00228821 (rank : 313)
Query Neighborhood Hits	524	Target Neighborhood Hits	230	Shared Neighborhood Hits	162
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

PSG3_HUMAN
NC score	0.479688 (rank : 164)	θ value	4.0297e-08 (rank : 174)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	220
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

SIGL5_MOUSE
NC score	0.479643 (rank : 165)	θ value	0.0563607 (rank : 357)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	241
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

MFA3L_MOUSE
NC score	0.479083 (rank : 166)	θ value	0.00102713 (rank : 302)
Query Neighborhood Hits	524	Target Neighborhood Hits	214	Shared Neighborhood Hits	192
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

PSG8_HUMAN
NC score	0.475381 (rank : 167)	θ value	5.81887e-07 (rank : 202)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	219
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PSG4_HUMAN
NC score	0.474595 (rank : 168)	θ value	7.59969e-07 (rank : 203)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	219
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

MUSK_MOUSE
NC score	0.468294 (rank : 169)	θ value	8.10077e-17 (rank : 84)
Query Neighborhood Hits	524	Target Neighborhood Hits	1057	Shared Neighborhood Hits	339
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MUSK_HUMAN
NC score	0.468004 (rank : 170)	θ value	3.63628e-17 (rank : 77)
Query Neighborhood Hits	524	Target Neighborhood Hits	1074	Shared Neighborhood Hits	345
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

ATL3_HUMAN
NC score	0.464644 (rank : 171)	θ value	1.47974e-10 (rank : 138)
Query Neighborhood Hits	524	Target Neighborhood Hits	414	Shared Neighborhood Hits	272
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

PSG7_HUMAN
NC score	0.460389 (rank : 172)	θ value	5.44631e-05 (rank : 257)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	218
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

PSG11_HUMAN
NC score	0.458400 (rank : 173)	θ value	9.92553e-07 (rank : 208)
Query Neighborhood Hits	524	Target Neighborhood Hits	223	Shared Neighborhood Hits	211
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG1_HUMAN
NC score	0.455816 (rank : 174)	θ value	2.21117e-06 (rank : 221)
Query Neighborhood Hits	524	Target Neighborhood Hits	232	Shared Neighborhood Hits	216
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

ESAM_HUMAN
NC score	0.455538 (rank : 175)	θ value	0.0330416 (rank : 346)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	191
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

PSG6_HUMAN
NC score	0.453934 (rank : 176)	θ value	2.36244e-08 (rank : 170)
Query Neighborhood Hits	524	Target Neighborhood Hits	231	Shared Neighborhood Hits	210
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

PSG10_HUMAN
NC score	0.450365 (rank : 177)	θ value	2.36244e-08 (rank : 169)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	208
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG2_HUMAN
NC score	0.449885 (rank : 178)	θ value	1.69304e-06 (rank : 217)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	213
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

IL6RB_HUMAN
NC score	0.439636 (rank : 179)	θ value	1.38499e-08 (rank : 163)
Query Neighborhood Hits	524	Target Neighborhood Hits	181	Shared Neighborhood Hits	131
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

CD276_HUMAN
NC score	0.437380 (rank : 180)	θ value	4.45536e-07 (rank : 198)
Query Neighborhood Hits	524	Target Neighborhood Hits	261	Shared Neighborhood Hits	183
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

PSG9_HUMAN
NC score	0.436477 (rank : 181)	θ value	1.53129e-07 (rank : 192)
Query Neighborhood Hits	524	Target Neighborhood Hits	221	Shared Neighborhood Hits	203
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

VGFR1_HUMAN
NC score	0.434497 (rank : 182)	θ value	7.32683e-18 (rank : 76)
Query Neighborhood Hits	524	Target Neighborhood Hits	1109	Shared Neighborhood Hits	340
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

CXAR_HUMAN
NC score	0.434447 (rank : 183)	θ value	5.44631e-05 (rank : 254)
Query Neighborhood Hits	524	Target Neighborhood Hits	245	Shared Neighborhood Hits	187
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

VGFR1_MOUSE
NC score	0.429959 (rank : 184)	θ value	3.18553e-13 (rank : 113)
Query Neighborhood Hits	524	Target Neighborhood Hits	1118	Shared Neighborhood Hits	340
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

PSG5_HUMAN
NC score	0.426838 (rank : 185)	θ value	1.87187e-05 (rank : 241)
Query Neighborhood Hits	524	Target Neighborhood Hits	231	Shared Neighborhood Hits	208
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

OBSCN_HUMAN
NC score	0.425762 (rank : 186)	θ value	9.87957e-23 (rank : 60)
Query Neighborhood Hits	524	Target Neighborhood Hits	1931	Shared Neighborhood Hits	404
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

USH2A_HUMAN
NC score	0.416455 (rank : 187)	θ value	1.73987e-27 (rank : 54)
Query Neighborhood Hits	524	Target Neighborhood Hits	600	Shared Neighborhood Hits	170
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

VGFR2_HUMAN
NC score	0.415078 (rank : 188)	θ value	5.08577e-11 (rank : 136)
Query Neighborhood Hits	524	Target Neighborhood Hits	1103	Shared Neighborhood Hits	334
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

LRFN4_HUMAN
NC score	0.414906 (rank : 189)	θ value	9.92553e-07 (rank : 206)
Query Neighborhood Hits	524	Target Neighborhood Hits	462	Shared Neighborhood Hits	224
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

CXAR_MOUSE
NC score	0.413089 (rank : 190)	θ value	0.00298849 (rank : 315)
Query Neighborhood Hits	524	Target Neighborhood Hits	250	Shared Neighborhood Hits	190
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

ESAM_MOUSE
NC score	0.410527 (rank : 191)	θ value	0.0330416 (rank : 347)
Query Neighborhood Hits	524	Target Neighborhood Hits	222	Shared Neighborhood Hits	183
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

VGFR2_MOUSE
NC score	0.410436 (rank : 192)	θ value	1.33837e-11 (rank : 131)
Query Neighborhood Hits	524	Target Neighborhood Hits	1089	Shared Neighborhood Hits	330
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

IL1R2_HUMAN
NC score	0.410118 (rank : 193)	θ value	0.0252991 (rank : 343)
Query Neighborhood Hits	524	Target Neighborhood Hits	153	Shared Neighborhood Hits	141
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

LRFN4_MOUSE
NC score	0.408938 (rank : 194)	θ value	4.1701e-05 (rank : 252)
Query Neighborhood Hits	524	Target Neighborhood Hits	442	Shared Neighborhood Hits	217
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

COCA1_MOUSE
NC score	0.408834 (rank : 195)	θ value	1.63604e-09 (rank : 148)
Query Neighborhood Hits	524	Target Neighborhood Hits	467	Shared Neighborhood Hits	164
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

LRFN2_HUMAN
NC score	0.406411 (rank : 196)	θ value	5.26297e-08 (rank : 178)
Query Neighborhood Hits	524	Target Neighborhood Hits	450	Shared Neighborhood Hits	220
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN2_MOUSE
NC score	0.405642 (rank : 197)	θ value	1.53129e-07 (rank : 191)
Query Neighborhood Hits	524	Target Neighborhood Hits	450	Shared Neighborhood Hits	225
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

PVRL3_MOUSE
NC score	0.404377 (rank : 198)	θ value	4.0297e-08 (rank : 175)
Query Neighborhood Hits	524	Target Neighborhood Hits	212	Shared Neighborhood Hits	173
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

MYLK_HUMAN
NC score	0.403445 (rank : 199)	θ value	9.54697e-26 (rank : 55)
Query Neighborhood Hits	524	Target Neighborhood Hits	1328	Shared Neighborhood Hits	377
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

LRFN3_MOUSE
NC score	0.401683 (rank : 200)	θ value	1.69304e-06 (rank : 214)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

MYLK_MOUSE
NC score	0.400087 (rank : 201)	θ value	4.73814e-25 (rank : 56)
Query Neighborhood Hits	524	Target Neighborhood Hits	1489	Shared Neighborhood Hits	362
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

USH2A_MOUSE
NC score	0.398331 (rank : 202)	θ value	1.5773e-20 (rank : 68)
Query Neighborhood Hits	524	Target Neighborhood Hits	626	Shared Neighborhood Hits	166
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

CILP2_HUMAN
NC score	0.396611 (rank : 203)	θ value	0.0330416 (rank : 345)
Query Neighborhood Hits	524	Target Neighborhood Hits	307	Shared Neighborhood Hits	194
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

SPEG_MOUSE
NC score	0.394961 (rank : 204)	θ value	1.5773e-20 (rank : 67)
Query Neighborhood Hits	524	Target Neighborhood Hits	1959	Shared Neighborhood Hits	347
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

COCA1_HUMAN
NC score	0.392817 (rank : 205)	θ value	4.30538e-10 (rank : 143)
Query Neighborhood Hits	524	Target Neighborhood Hits	458	Shared Neighborhood Hits	155
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

IL6RB_MOUSE
NC score	0.392804 (rank : 206)	θ value	0.000786445 (rank : 297)
Query Neighborhood Hits	524	Target Neighborhood Hits	168	Shared Neighborhood Hits	128
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

LIFR_HUMAN
NC score	0.392562 (rank : 207)	θ value	5.81887e-07 (rank : 200)
Query Neighborhood Hits	524	Target Neighborhood Hits	130	Shared Neighborhood Hits	95
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

SPEG_HUMAN
NC score	0.391323 (rank : 208)	θ value	8.65492e-19 (rank : 73)
Query Neighborhood Hits	524	Target Neighborhood Hits	1762	Shared Neighborhood Hits	342
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SIGL5_HUMAN
NC score	0.390705 (rank : 209)	θ value	0.0193708 (rank : 341)
Query Neighborhood Hits	524	Target Neighborhood Hits	246	Shared Neighborhood Hits	199
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

PVRL3_HUMAN
NC score	0.389232 (rank : 210)	θ value	5.26297e-08 (rank : 179)
Query Neighborhood Hits	524	Target Neighborhood Hits	204	Shared Neighborhood Hits	166
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

NRG1_HUMAN
NC score	0.386340 (rank : 211)	θ value	0.47712 (rank : 396)
Query Neighborhood Hits	524	Target Neighborhood Hits	285	Shared Neighborhood Hits	164
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

PECA1_HUMAN
NC score	0.383117 (rank : 212)	θ value	0.00298849 (rank : 320)
Query Neighborhood Hits	524	Target Neighborhood Hits	178	Shared Neighborhood Hits	151
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

LRFN5_MOUSE
NC score	0.382682 (rank : 213)	θ value	1.29631e-06 (rank : 211)
Query Neighborhood Hits	524	Target Neighborhood Hits	472	Shared Neighborhood Hits	230
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

LRFN3_HUMAN
NC score	0.382400 (rank : 214)	θ value	3.77169e-06 (rank : 228)
Query Neighborhood Hits	524	Target Neighborhood Hits	444	Shared Neighborhood Hits	213
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

LRC21_MOUSE
NC score	0.381874 (rank : 215)	θ value	0.00134147 (rank : 307)
Query Neighborhood Hits	524	Target Neighborhood Hits	462	Shared Neighborhood Hits	237
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

ITB4_HUMAN
NC score	0.379219 (rank : 216)	θ value	1.02475e-11 (rank : 129)
Query Neighborhood Hits	524	Target Neighborhood Hits	458	Shared Neighborhood Hits	156
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

LIFR_MOUSE
NC score	0.379095 (rank : 217)	θ value	5.44631e-05 (rank : 255)
Query Neighborhood Hits	524	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

LRC21_HUMAN
NC score	0.378518 (rank : 218)	θ value	0.00390308 (rank : 323)
Query Neighborhood Hits	524	Target Neighborhood Hits	456	Shared Neighborhood Hits	237
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

I12R2_HUMAN
NC score	0.377506 (rank : 219)	θ value	1.53129e-07 (rank : 189)
Query Neighborhood Hits	524	Target Neighborhood Hits	163	Shared Neighborhood Hits	113
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

LRFN5_HUMAN
NC score	0.376276 (rank : 220)	θ value	3.41135e-07 (rank : 197)
Query Neighborhood Hits	524	Target Neighborhood Hits	464	Shared Neighborhood Hits	225
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

I12R2_MOUSE
NC score	0.375901 (rank : 221)	θ value	1.69304e-06 (rank : 213)
Query Neighborhood Hits	524	Target Neighborhood Hits	143	Shared Neighborhood Hits	113
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

PVRL1_HUMAN
NC score	0.371336 (rank : 222)	θ value	0.000602161 (rank : 293)
Query Neighborhood Hits	524	Target Neighborhood Hits	219	Shared Neighborhood Hits	167
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

FGFR4_MOUSE
NC score	0.368906 (rank : 223)	θ value	2.52405e-10 (rank : 141)
Query Neighborhood Hits	524	Target Neighborhood Hits	1026	Shared Neighborhood Hits	301
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

SIGL8_HUMAN
NC score	0.363320 (rank : 224)	θ value	6.88961 (rank : 504)
Query Neighborhood Hits	524	Target Neighborhood Hits	252	Shared Neighborhood Hits	218
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

FGFR4_HUMAN
NC score	0.362450 (rank : 225)	θ value	1.25267e-09 (rank : 146)
Query Neighborhood Hits	524	Target Neighborhood Hits	1037	Shared Neighborhood Hits	301
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

LRRN1_HUMAN
NC score	0.361518 (rank : 226)	θ value	1.25267e-09 (rank : 147)
Query Neighborhood Hits	524	Target Neighborhood Hits	518	Shared Neighborhood Hits	262
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

CD276_MOUSE
NC score	0.359858 (rank : 227)	θ value	0.000602161 (rank : 291)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	182
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

TYRO3_HUMAN
NC score	0.359522 (rank : 228)	θ value	8.95645e-16 (rank : 94)
Query Neighborhood Hits	524	Target Neighborhood Hits	995	Shared Neighborhood Hits	283
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

FGFR3_MOUSE
NC score	0.358692 (rank : 229)	θ value	1.38499e-08 (rank : 162)
Query Neighborhood Hits	524	Target Neighborhood Hits	1059	Shared Neighborhood Hits	301
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

LRRN3_HUMAN
NC score	0.358505 (rank : 230)	θ value	2.88788e-06 (rank : 223)
Query Neighborhood Hits	524	Target Neighborhood Hits	461	Shared Neighborhood Hits	228
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

TYRO3_MOUSE
NC score	0.355625 (rank : 231)	θ value	1.2105e-12 (rank : 118)
Query Neighborhood Hits	524	Target Neighborhood Hits	1007	Shared Neighborhood Hits	287
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

PVRL1_MOUSE
NC score	0.355559 (rank : 232)	θ value	0.00175202 (rank : 311)
Query Neighborhood Hits	524	Target Neighborhood Hits	201	Shared Neighborhood Hits	158
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

VGFR3_MOUSE
NC score	0.355501 (rank : 233)	θ value	1.38499e-08 (rank : 164)
Query Neighborhood Hits	524	Target Neighborhood Hits	1056	Shared Neighborhood Hits	310
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_HUMAN
NC score	0.355019 (rank : 234)	θ value	2.79066e-09 (rank : 151)
Query Neighborhood Hits	524	Target Neighborhood Hits	1037	Shared Neighborhood Hits	297
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR1_HUMAN
NC score	0.354543 (rank : 235)	θ value	1.02475e-11 (rank : 128)
Query Neighborhood Hits	524	Target Neighborhood Hits	1069	Shared Neighborhood Hits	301
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

CILP1_MOUSE
NC score	0.354158 (rank : 236)	θ value	0.000158464 (rank : 271)
Query Neighborhood Hits	524	Target Neighborhood Hits	282	Shared Neighborhood Hits	193
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

FGFR1_MOUSE
NC score	0.353915 (rank : 237)	θ value	2.28291e-11 (rank : 133)
Query Neighborhood Hits	524	Target Neighborhood Hits	1068	Shared Neighborhood Hits	299
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

COEA1_MOUSE
NC score	0.352098 (rank : 238)	θ value	3.18553e-13 (rank : 109)
Query Neighborhood Hits	524	Target Neighborhood Hits	402	Shared Neighborhood Hits	114
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

LRRN1_MOUSE
NC score	0.350745 (rank : 239)	θ value	1.63604e-09 (rank : 150)
Query Neighborhood Hits	524	Target Neighborhood Hits	508	Shared Neighborhood Hits	258
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

SIG12_HUMAN
NC score	0.349739 (rank : 240)	θ value	3.0926 (rank : 444)
Query Neighborhood Hits	524	Target Neighborhood Hits	245	Shared Neighborhood Hits	219
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

FGFR3_HUMAN
NC score	0.347248 (rank : 241)	θ value	1.17247e-07 (rank : 184)
Query Neighborhood Hits	524	Target Neighborhood Hits	1042	Shared Neighborhood Hits	292
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

PTPRM_HUMAN
NC score	0.345391 (rank : 242)	θ value	4.16044e-13 (rank : 115)
Query Neighborhood Hits	524	Target Neighborhood Hits	244	Shared Neighborhood Hits	155
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

LRRN3_MOUSE
NC score	0.342805 (rank : 243)	θ value	2.21117e-06 (rank : 219)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	224
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

IRPL2_HUMAN
NC score	0.342571 (rank : 244)	θ value	0.00298849 (rank : 319)
Query Neighborhood Hits	524	Target Neighborhood Hits	194	Shared Neighborhood Hits	155
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

FGFR2_HUMAN
NC score	0.342273 (rank : 245)	θ value	1.63604e-09 (rank : 149)
Query Neighborhood Hits	524	Target Neighborhood Hits	1062	Shared Neighborhood Hits	286
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

SIGL6_HUMAN
NC score	0.341991 (rank : 246)	θ value	8.99809 (rank : 524)
Query Neighborhood Hits	524	Target Neighborhood Hits	233	Shared Neighborhood Hits	202
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

IL1R2_MOUSE
NC score	0.341569 (rank : 247)	θ value	0.00228821 (rank : 314)
Query Neighborhood Hits	524	Target Neighborhood Hits	125	Shared Neighborhood Hits	108
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

PTPRM_MOUSE
NC score	0.341562 (rank : 248)	θ value	3.18553e-13 (rank : 112)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	154
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

IRPL2_MOUSE
NC score	0.339061 (rank : 249)	θ value	0.00390308 (rank : 322)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	154
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

IRPL1_MOUSE
NC score	0.338642 (rank : 250)	θ value	0.00869519 (rank : 327)
Query Neighborhood Hits	524	Target Neighborhood Hits	186	Shared Neighborhood Hits	163
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

CEAM7_HUMAN
NC score	0.338508 (rank : 251)	θ value	0.000158464 (rank : 270)
Query Neighborhood Hits	524	Target Neighborhood Hits	170	Shared Neighborhood Hits	147
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

LRRN5_HUMAN
NC score	0.338138 (rank : 252)	θ value	2.21117e-06 (rank : 220)
Query Neighborhood Hits	524	Target Neighborhood Hits	493	Shared Neighborhood Hits	240
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

UNC5D_MOUSE
NC score	0.335080 (rank : 253)	θ value	0.0736092 (rank : 363)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	186
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

FGFR2_MOUSE
NC score	0.331543 (rank : 254)	θ value	8.97725e-08 (rank : 182)
Query Neighborhood Hits	524	Target Neighborhood Hits	1062	Shared Neighborhood Hits	287
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

IRPL1_HUMAN
NC score	0.330472 (rank : 255)	θ value	0.0193708 (rank : 340)
Query Neighborhood Hits	524	Target Neighborhood Hits	196	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

PDL1_HUMAN
NC score	0.330328 (rank : 256)	θ value	0.0330416 (rank : 349)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

UNC5D_HUMAN
NC score	0.329370 (rank : 257)	θ value	0.0736092 (rank : 362)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	184
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

CILP1_HUMAN
NC score	0.328171 (rank : 258)	θ value	0.00665767 (rank : 324)
Query Neighborhood Hits	524	Target Neighborhood Hits	266	Shared Neighborhood Hits	173
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

MOX2R_MOUSE
NC score	0.325045 (rank : 259)	θ value	0.0431538 (rank : 352)
Query Neighborhood Hits	524	Target Neighborhood Hits	110	Shared Neighborhood Hits	103
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

PVR_HUMAN
NC score	0.324398 (rank : 260)	θ value	1.17247e-07 (rank : 186)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	142
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

MERTK_HUMAN
NC score	0.323627 (rank : 261)	θ value	4.74913e-17 (rank : 81)
Query Neighborhood Hits	524	Target Neighborhood Hits	988	Shared Neighborhood Hits	266
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

TENN_MOUSE
NC score	0.323030 (rank : 262)	θ value	1.69304e-06 (rank : 218)
Query Neighborhood Hits	524	Target Neighborhood Hits	484	Shared Neighborhood Hits	151
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TENR_HUMAN
NC score	0.320369 (rank : 263)	θ value	1.17247e-07 (rank : 187)
Query Neighborhood Hits	524	Target Neighborhood Hits	526	Shared Neighborhood Hits	158
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

CSF1R_MOUSE
NC score	0.317977 (rank : 264)	θ value	9.29e-05 (rank : 261)
Query Neighborhood Hits	524	Target Neighborhood Hits	983	Shared Neighborhood Hits	252
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EMB_MOUSE
NC score	0.315130 (rank : 265)	θ value	0.000121331 (rank : 265)
Query Neighborhood Hits	524	Target Neighborhood Hits	83	Shared Neighborhood Hits	81
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

MERTK_MOUSE
NC score	0.315076 (rank : 266)	θ value	7.58209e-15 (rank : 101)
Query Neighborhood Hits	524	Target Neighborhood Hits	974	Shared Neighborhood Hits	262
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PTPRT_MOUSE
NC score	0.313129 (rank : 267)	θ value	2.36244e-08 (rank : 172)
Query Neighborhood Hits	524	Target Neighborhood Hits	219	Shared Neighborhood Hits	133
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PGFRL_HUMAN
NC score	0.312782 (rank : 268)	θ value	0.279714 (rank : 382)
Query Neighborhood Hits	524	Target Neighborhood Hits	115	Shared Neighborhood Hits	113
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PTPRT_HUMAN
NC score	0.312032 (rank : 269)	θ value	2.36244e-08 (rank : 171)
Query Neighborhood Hits	524	Target Neighborhood Hits	217	Shared Neighborhood Hits	131
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

TENR_MOUSE
NC score	0.310288 (rank : 270)	θ value	4.92598e-06 (rank : 231)
Query Neighborhood Hits	524	Target Neighborhood Hits	531	Shared Neighborhood Hits	150
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

IL1R1_HUMAN
NC score	0.307261 (rank : 271)	θ value	0.000270298 (rank : 280)
Query Neighborhood Hits	524	Target Neighborhood Hits	140	Shared Neighborhood Hits	126
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

COEA1_HUMAN
NC score	0.306216 (rank : 272)	θ value	1.25267e-09 (rank : 145)
Query Neighborhood Hits	524	Target Neighborhood Hits	427	Shared Neighborhood Hits	123
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

UFO_MOUSE
NC score	0.304052 (rank : 273)	θ value	2.52405e-10 (rank : 142)
Query Neighborhood Hits	524	Target Neighborhood Hits	988	Shared Neighborhood Hits	255
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

PVRL2_MOUSE
NC score	0.303699 (rank : 274)	θ value	θ > 10 (rank : 1088)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	141
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

PIGR_MOUSE
NC score	0.302808 (rank : 275)	θ value	0.279714 (rank : 383)
Query Neighborhood Hits	524	Target Neighborhood Hits	214	Shared Neighborhood Hits	151
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

ROR2_MOUSE
NC score	0.301489 (rank : 276)	θ value	4.92598e-06 (rank : 230)
Query Neighborhood Hits	524	Target Neighborhood Hits	1000	Shared Neighborhood Hits	264
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

CSF3R_HUMAN
NC score	0.300822 (rank : 277)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	524	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

LRC24_HUMAN
NC score	0.298360 (rank : 278)	θ value	0.000786445 (rank : 298)
Query Neighborhood Hits	524	Target Neighborhood Hits	404	Shared Neighborhood Hits	195
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

PECA1_MOUSE
NC score	0.297163 (rank : 279)	θ value	1.09739e-05 (rank : 237)
Query Neighborhood Hits	524	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

UFO_HUMAN
NC score	0.296934 (rank : 280)	θ value	1.9326e-10 (rank : 140)
Query Neighborhood Hits	524	Target Neighborhood Hits	981	Shared Neighborhood Hits	248
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ILRL2_MOUSE
NC score	0.293398 (rank : 281)	θ value	0.0431538 (rank : 351)
Query Neighborhood Hits	524	Target Neighborhood Hits	158	Shared Neighborhood Hits	147
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

NTRK3_HUMAN
NC score	0.293144 (rank : 282)	θ value	5.44631e-05 (rank : 256)
Query Neighborhood Hits	524	Target Neighborhood Hits	1115	Shared Neighborhood Hits	258
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NTRK2_HUMAN
NC score	0.291986 (rank : 283)	θ value	2.44474e-05 (rank : 248)
Query Neighborhood Hits	524	Target Neighborhood Hits	1081	Shared Neighborhood Hits	261
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.291441 (rank : 284)	θ value	0.000121331 (rank : 269)
Query Neighborhood Hits	524	Target Neighborhood Hits	1088	Shared Neighborhood Hits	261
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

ROR2_HUMAN
NC score	0.290968 (rank : 285)	θ value	1.43324e-05 (rank : 240)
Query Neighborhood Hits	524	Target Neighborhood Hits	1014	Shared Neighborhood Hits	260
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

PTPRU_HUMAN
NC score	0.290085 (rank : 286)	θ value	3.0926 (rank : 443)
Query Neighborhood Hits	524	Target Neighborhood Hits	237	Shared Neighborhood Hits	149
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

COKA1_HUMAN
NC score	0.289798 (rank : 287)	θ value	3.64472e-09 (rank : 152)
Query Neighborhood Hits	524	Target Neighborhood Hits	403	Shared Neighborhood Hits	115
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

IL1R1_MOUSE
NC score	0.289522 (rank : 288)	θ value	7.1131e-05 (rank : 259)
Query Neighborhood Hits	524	Target Neighborhood Hits	142	Shared Neighborhood Hits	127
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

PGFRA_HUMAN
NC score	0.287747 (rank : 289)	θ value	1.09739e-05 (rank : 238)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	241
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
NC score	0.287414 (rank : 290)	θ value	3.64472e-09 (rank : 154)
Query Neighborhood Hits	524	Target Neighborhood Hits	975	Shared Neighborhood Hits	242
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PVRL2_HUMAN
NC score	0.286774 (rank : 291)	θ value	0.0148317 (rank : 337)
Query Neighborhood Hits	524	Target Neighborhood Hits	185	Shared Neighborhood Hits	131
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

CO7A1_HUMAN
NC score	0.285183 (rank : 292)	θ value	1.133e-10 (rank : 137)
Query Neighborhood Hits	524	Target Neighborhood Hits	807	Shared Neighborhood Hits	153
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

KALM_HUMAN
NC score	0.283652 (rank : 293)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	524	Target Neighborhood Hits	114	Shared Neighborhood Hits	76
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

PTPRK_MOUSE
NC score	0.282199 (rank : 294)	θ value	1.09739e-05 (rank : 239)
Query Neighborhood Hits	524	Target Neighborhood Hits	223	Shared Neighborhood Hits	136
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

TENN_HUMAN
NC score	0.282154 (rank : 295)	θ value	0.00665767 (rank : 326)
Query Neighborhood Hits	524	Target Neighborhood Hits	453	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

NGL1_MOUSE
NC score	0.281687 (rank : 296)	θ value	0.00035302 (rank : 287)
Query Neighborhood Hits	524	Target Neighborhood Hits	512	Shared Neighborhood Hits	227
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_HUMAN
NC score	0.281323 (rank : 297)	θ value	0.00035302 (rank : 286)
Query Neighborhood Hits	524	Target Neighborhood Hits	511	Shared Neighborhood Hits	227
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

PGFRB_MOUSE
NC score	0.280903 (rank : 298)	θ value	0.00665767 (rank : 325)
Query Neighborhood Hits	524	Target Neighborhood Hits	960	Shared Neighborhood Hits	225
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

ROR1_HUMAN
NC score	0.279877 (rank : 299)	θ value	2.88788e-06 (rank : 225)
Query Neighborhood Hits	524	Target Neighborhood Hits	1018	Shared Neighborhood Hits	255
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

KIT_MOUSE
NC score	0.278927 (rank : 300)	θ value	6.87365e-08 (rank : 181)
Query Neighborhood Hits	524	Target Neighborhood Hits	949	Shared Neighborhood Hits	225
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

DUET_HUMAN
NC score	0.278614 (rank : 301)	θ value	6.41864e-14 (rank : 105)
Query Neighborhood Hits	524	Target Neighborhood Hits	1220	Shared Neighborhood Hits	282
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

LRC4B_MOUSE
NC score	0.278606 (rank : 302)	θ value	0.00035302 (rank : 285)
Query Neighborhood Hits	524	Target Neighborhood Hits	484	Shared Neighborhood Hits	216
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

PTPRK_HUMAN
NC score	0.278249 (rank : 303)	θ value	3.19293e-05 (rank : 251)
Query Neighborhood Hits	524	Target Neighborhood Hits	228	Shared Neighborhood Hits	137
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

ROR1_MOUSE
NC score	0.277812 (rank : 304)	θ value	2.88788e-06 (rank : 226)
Query Neighborhood Hits	524	Target Neighborhood Hits	1025	Shared Neighborhood Hits	258
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

HCFC2_MOUSE
NC score	0.276856 (rank : 305)	θ value	1.06291 (rank : 407)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

LRC4B_HUMAN
NC score	0.275983 (rank : 306)	θ value	0.00035302 (rank : 284)
Query Neighborhood Hits	524	Target Neighborhood Hits	479	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC24_MOUSE
NC score	0.274901 (rank : 307)	θ value	0.0148317 (rank : 336)
Query Neighborhood Hits	524	Target Neighborhood Hits	387	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

PDL1_MOUSE
NC score	0.272548 (rank : 308)	θ value	4.03905 (rank : 465)
Query Neighborhood Hits	524	Target Neighborhood Hits	168	Shared Neighborhood Hits	134
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PGFRL_MOUSE
NC score	0.271881 (rank : 309)	θ value	0.0330416 (rank : 350)
Query Neighborhood Hits	524	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PGFRB_HUMAN
NC score	0.271695 (rank : 310)	θ value	4.1701e-05 (rank : 253)
Query Neighborhood Hits	524	Target Neighborhood Hits	962	Shared Neighborhood Hits	231
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

UNC5A_HUMAN
NC score	0.271148 (rank : 311)	θ value	0.0113563 (rank : 333)
Query Neighborhood Hits	524	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

PIGR_HUMAN
NC score	0.267978 (rank : 312)	θ value	θ > 10 (rank : 1018)
Query Neighborhood Hits	524	Target Neighborhood Hits	164	Shared Neighborhood Hits	115
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

CSF1R_HUMAN
NC score	0.266785 (rank : 313)	θ value	0.00035302 (rank : 282)
Query Neighborhood Hits	524	Target Neighborhood Hits	943	Shared Neighborhood Hits	214
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ILRL1_HUMAN
NC score	0.266343 (rank : 314)	θ value	0.0330416 (rank : 348)
Query Neighborhood Hits	524	Target Neighborhood Hits	167	Shared Neighborhood Hits	133
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

IGS21_HUMAN
NC score	0.265986 (rank : 315)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	524	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

UNC5C_MOUSE
NC score	0.264724 (rank : 316)	θ value	3.0926 (rank : 451)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	133
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.264090 (rank : 317)	θ value	3.0926 (rank : 450)
Query Neighborhood Hits	524	Target Neighborhood Hits	226	Shared Neighborhood Hits	129
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

KIT_HUMAN
NC score	0.264018 (rank : 318)	θ value	0.000158464 (rank : 272)
Query Neighborhood Hits	524	Target Neighborhood Hits	953	Shared Neighborhood Hits	218
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

IGS21_MOUSE
NC score	0.263031 (rank : 319)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	524	Target Neighborhood Hits	118	Shared Neighborhood Hits	106
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

CSF3R_MOUSE
NC score	0.262999 (rank : 320)	θ value	0.000121331 (rank : 264)
Query Neighborhood Hits	524	Target Neighborhood Hits	104	Shared Neighborhood Hits	86
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

JAML1_MOUSE
NC score	0.259538 (rank : 321)	θ value	0.0113563 (rank : 332)
Query Neighborhood Hits	524	Target Neighborhood Hits	185	Shared Neighborhood Hits	135
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

TIE1_MOUSE
NC score	0.257716 (rank : 322)	θ value	2.88788e-06 (rank : 227)
Query Neighborhood Hits	524	Target Neighborhood Hits	1266	Shared Neighborhood Hits	227
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

SORL_HUMAN
NC score	0.256435 (rank : 323)	θ value	6.00763e-12 (rank : 125)
Query Neighborhood Hits	524	Target Neighborhood Hits	440	Shared Neighborhood Hits	128
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SIGL7_HUMAN
NC score	0.255224 (rank : 324)	θ value	θ > 10 (rank : 1120)
Query Neighborhood Hits	524	Target Neighborhood Hits	180	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

PDL2_MOUSE
NC score	0.252303 (rank : 325)	θ value	5.27518 (rank : 482)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	102
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

UNC5B_HUMAN
NC score	0.251778 (rank : 326)	θ value	3.0926 (rank : 448)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	134
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

TENA_HUMAN
NC score	0.251358 (rank : 327)	θ value	7.34386e-10 (rank : 144)
Query Neighborhood Hits	524	Target Neighborhood Hits	631	Shared Neighborhood Hits	150
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

SORL_MOUSE
NC score	0.250292 (rank : 328)	θ value	1.80886e-08 (rank : 167)
Query Neighborhood Hits	524	Target Neighborhood Hits	439	Shared Neighborhood Hits	126
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

LRRC4_HUMAN
NC score	0.249559 (rank : 329)	θ value	0.00020696 (rank : 278)
Query Neighborhood Hits	524	Target Neighborhood Hits	444	Shared Neighborhood Hits	196
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

TIE1_HUMAN
NC score	0.249537 (rank : 330)	θ value	1.87187e-05 (rank : 242)
Query Neighborhood Hits	524	Target Neighborhood Hits	1241	Shared Neighborhood Hits	214
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

SIG12_MOUSE
NC score	0.248828 (rank : 331)	θ value	3.0926 (rank : 445)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	170
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

UNC5B_MOUSE
NC score	0.246980 (rank : 332)	θ value	3.0926 (rank : 449)
Query Neighborhood Hits	524	Target Neighborhood Hits	226	Shared Neighborhood Hits	135
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

TENX_HUMAN
NC score	0.245404 (rank : 333)	θ value	2.44474e-05 (rank : 249)
Query Neighborhood Hits	524	Target Neighborhood Hits	789	Shared Neighborhood Hits	155
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

FCERA_HUMAN
NC score	0.245062 (rank : 334)	θ value	5.27518 (rank : 472)
Query Neighborhood Hits	524	Target Neighborhood Hits	150	Shared Neighborhood Hits	118
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

UNC5A_MOUSE
NC score	0.240822 (rank : 335)	θ value	0.0113563 (rank : 334)
Query Neighborhood Hits	524	Target Neighborhood Hits	203	Shared Neighborhood Hits	120
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

TIE2_MOUSE
NC score	0.240532 (rank : 336)	θ value	2.21117e-06 (rank : 222)
Query Neighborhood Hits	524	Target Neighborhood Hits	1204	Shared Neighborhood Hits	197
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

HHLA2_HUMAN
NC score	0.239741 (rank : 337)	θ value	0.163984 (rank : 367)
Query Neighborhood Hits	524	Target Neighborhood Hits	140	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

TIE2_HUMAN
NC score	0.238662 (rank : 338)	θ value	9.92553e-07 (rank : 209)
Query Neighborhood Hits	524	Target Neighborhood Hits	1192	Shared Neighborhood Hits	195
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

EPHB6_HUMAN
NC score	0.236340 (rank : 339)	θ value	0.00102713 (rank : 299)
Query Neighborhood Hits	524	Target Neighborhood Hits	912	Shared Neighborhood Hits	178
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

TENA_MOUSE
NC score	0.235726 (rank : 340)	θ value	1.99992e-07 (rank : 195)
Query Neighborhood Hits	524	Target Neighborhood Hits	596	Shared Neighborhood Hits	141
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

OX2G_MOUSE
NC score	0.232443 (rank : 341)	θ value	5.27518 (rank : 481)
Query Neighborhood Hits	524	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

FCGR1_HUMAN
NC score	0.231273 (rank : 342)	θ value	0.62314 (rank : 400)
Query Neighborhood Hits	524	Target Neighborhood Hits	145	Shared Neighborhood Hits	108
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

ROS_HUMAN
NC score	0.229972 (rank : 343)	θ value	0.00175202 (rank : 312)
Query Neighborhood Hits	524	Target Neighborhood Hits	907	Shared Neighborhood Hits	181
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

EPHB6_MOUSE
NC score	0.229919 (rank : 344)	θ value	0.00298849 (rank : 318)
Query Neighborhood Hits	524	Target Neighborhood Hits	906	Shared Neighborhood Hits	170
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHA7_HUMAN
NC score	0.227807 (rank : 345)	θ value	1.06045e-08 (rank : 159)
Query Neighborhood Hits	524	Target Neighborhood Hits	1053	Shared Neighborhood Hits	181
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
NC score	0.225829 (rank : 346)	θ value	8.11959e-09 (rank : 158)
Query Neighborhood Hits	524	Target Neighborhood Hits	1025	Shared Neighborhood Hits	181
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

CD80_MOUSE
NC score	0.225230 (rank : 347)	θ value	0.813845 (rank : 401)
Query Neighborhood Hits	524	Target Neighborhood Hits	136	Shared Neighborhood Hits	112
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

EPHA8_MOUSE
NC score	0.224564 (rank : 348)	θ value	0.000270298 (rank : 279)
Query Neighborhood Hits	524	Target Neighborhood Hits	969	Shared Neighborhood Hits	186
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHB3_MOUSE
NC score	0.223781 (rank : 349)	θ value	0.00020696 (rank : 274)
Query Neighborhood Hits	524	Target Neighborhood Hits	996	Shared Neighborhood Hits	184
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB3_HUMAN
NC score	0.222271 (rank : 350)	θ value	0.000461057 (rank : 289)
Query Neighborhood Hits	524	Target Neighborhood Hits	996	Shared Neighborhood Hits	184
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA8_HUMAN
NC score	0.221783 (rank : 351)	θ value	0.00020696 (rank : 273)
Query Neighborhood Hits	524	Target Neighborhood Hits	956	Shared Neighborhood Hits	183
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

CD80_HUMAN
NC score	0.221205 (rank : 352)	θ value	8.99809 (rank : 511)
Query Neighborhood Hits	524	Target Neighborhood Hits	129	Shared Neighborhood Hits	108
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

EPHA3_MOUSE
NC score	0.220653 (rank : 353)	θ value	2.44474e-05 (rank : 246)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	188
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_MOUSE
NC score	0.218762 (rank : 354)	θ value	0.0736092 (rank : 360)
Query Neighborhood Hits	524	Target Neighborhood Hits	982	Shared Neighborhood Hits	181
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

LRRC4_MOUSE
NC score	0.217162 (rank : 355)	θ value	0.0961366 (rank : 365)
Query Neighborhood Hits	524	Target Neighborhood Hits	412	Shared Neighborhood Hits	170
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

EPHA3_HUMAN
NC score	0.217109 (rank : 356)	θ value	0.00298849 (rank : 316)
Query Neighborhood Hits	524	Target Neighborhood Hits	1005	Shared Neighborhood Hits	187
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA4_HUMAN
NC score	0.216211 (rank : 357)	θ value	0.0563607 (rank : 355)
Query Neighborhood Hits	524	Target Neighborhood Hits	975	Shared Neighborhood Hits	178
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHB4_MOUSE
NC score	0.215945 (rank : 358)	θ value	0.00020696 (rank : 275)
Query Neighborhood Hits	524	Target Neighborhood Hits	1013	Shared Neighborhood Hits	182
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

TARSH_HUMAN
NC score	0.214800 (rank : 359)	θ value	1.38821 (rank : 419)
Query Neighborhood Hits	524	Target Neighborhood Hits	768	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

OX2G_HUMAN
NC score	0.211032 (rank : 360)	θ value	θ > 10 (rank : 987)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	88
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

EPHB4_HUMAN
NC score	0.210196 (rank : 361)	θ value	0.000786445 (rank : 295)
Query Neighborhood Hits	524	Target Neighborhood Hits	1056	Shared Neighborhood Hits	185
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ILRL1_MOUSE
NC score	0.209662 (rank : 362)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	524	Target Neighborhood Hits	172	Shared Neighborhood Hits	134
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

LAG3_MOUSE
NC score	0.209222 (rank : 363)	θ value	4.03905 (rank : 462)
Query Neighborhood Hits	524	Target Neighborhood Hits	117	Shared Neighborhood Hits	93
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

PTPRB_HUMAN
NC score	0.208517 (rank : 364)	θ value	0.163984 (rank : 368)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	105
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

EPHA5_HUMAN
NC score	0.207860 (rank : 365)	θ value	0.163984 (rank : 366)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	182
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

FLT3_MOUSE
NC score	0.205419 (rank : 366)	θ value	0.00102713 (rank : 300)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	137
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

EPHB1_HUMAN
NC score	0.203925 (rank : 367)	θ value	0.00298849 (rank : 317)
Query Neighborhood Hits	524	Target Neighborhood Hits	988	Shared Neighborhood Hits	174
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_MOUSE
NC score	0.203143 (rank : 368)	θ value	0.000786445 (rank : 294)
Query Neighborhood Hits	524	Target Neighborhood Hits	982	Shared Neighborhood Hits	170
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.203132 (rank : 369)	θ value	0.000602161 (rank : 292)
Query Neighborhood Hits	524	Target Neighborhood Hits	983	Shared Neighborhood Hits	170
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

CD79A_HUMAN
NC score	0.202725 (rank : 370)	θ value	2.36792 (rank : 426)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

EPHA2_HUMAN
NC score	0.202242 (rank : 371)	θ value	1.09739e-05 (rank : 236)
Query Neighborhood Hits	524	Target Neighborhood Hits	1021	Shared Neighborhood Hits	170
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EMB_HUMAN
NC score	0.201880 (rank : 372)	θ value	0.00175202 (rank : 308)
Query Neighborhood Hits	524	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

NTRK1_HUMAN
NC score	0.201168 (rank : 373)	θ value	0.0563607 (rank : 356)
Query Neighborhood Hits	524	Target Neighborhood Hits	1023	Shared Neighborhood Hits	194
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

CT075_HUMAN
NC score	0.198969 (rank : 374)	θ value	0.0563607 (rank : 354)
Query Neighborhood Hits	524	Target Neighborhood Hits	387	Shared Neighborhood Hits	115
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

PDL2_HUMAN
NC score	0.197914 (rank : 375)	θ value	θ > 10 (rank : 1009)
Query Neighborhood Hits	524	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

EPHA2_MOUSE
NC score	0.196982 (rank : 376)	θ value	5.81887e-07 (rank : 199)
Query Neighborhood Hits	524	Target Neighborhood Hits	1020	Shared Neighborhood Hits	164
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

INSRR_HUMAN
NC score	0.195872 (rank : 377)	θ value	0.000121331 (rank : 266)
Query Neighborhood Hits	524	Target Neighborhood Hits	950	Shared Neighborhood Hits	138
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
NC score	0.195509 (rank : 378)	θ value	0.000121331 (rank : 267)
Query Neighborhood Hits	524	Target Neighborhood Hits	961	Shared Neighborhood Hits	138
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ILRL2_HUMAN
NC score	0.194857 (rank : 379)	θ value	0.21417 (rank : 374)
Query Neighborhood Hits	524	Target Neighborhood Hits	112	Shared Neighborhood Hits	99
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

FCGR1_MOUSE
NC score	0.193999 (rank : 380)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	524	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

TRIO_HUMAN
NC score	0.193816 (rank : 381)	θ value	5.44631e-05 (rank : 258)
Query Neighborhood Hits	524	Target Neighborhood Hits	1580	Shared Neighborhood Hits	283
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SHPS1_HUMAN
NC score	0.193289 (rank : 382)	θ value	4.03905 (rank : 469)
Query Neighborhood Hits	524	Target Neighborhood Hits	455	Shared Neighborhood Hits	143
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

EPHA6_HUMAN
NC score	0.192387 (rank : 383)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	524	Target Neighborhood Hits	959	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA5_MOUSE
NC score	0.191012 (rank : 384)	θ value	0.0113563 (rank : 329)
Query Neighborhood Hits	524	Target Neighborhood Hits	950	Shared Neighborhood Hits	169
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

IGF1R_HUMAN
NC score	0.190638 (rank : 385)	θ value	1.29631e-06 (rank : 210)
Query Neighborhood Hits	524	Target Neighborhood Hits	977	Shared Neighborhood Hits	141
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
NC score	0.189506 (rank : 386)	θ value	4.92598e-06 (rank : 229)
Query Neighborhood Hits	524	Target Neighborhood Hits	973	Shared Neighborhood Hits	140
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LAG3_HUMAN
NC score	0.188666 (rank : 387)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	524	Target Neighborhood Hits	129	Shared Neighborhood Hits	87
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

INSR_MOUSE
NC score	0.187954 (rank : 388)	θ value	0.000461057 (rank : 290)
Query Neighborhood Hits	524	Target Neighborhood Hits	968	Shared Neighborhood Hits	138
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IL27B_HUMAN
NC score	0.187701 (rank : 389)	θ value	0.21417 (rank : 373)
Query Neighborhood Hits	524	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

EPHAA_HUMAN
NC score	0.186670 (rank : 390)	θ value	0.279714 (rank : 378)
Query Neighborhood Hits	524	Target Neighborhood Hits	960	Shared Neighborhood Hits	151
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ICAM1_MOUSE
NC score	0.185754 (rank : 391)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	524	Target Neighborhood Hits	99	Shared Neighborhood Hits	87
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

INSR_HUMAN
NC score	0.183503 (rank : 392)	θ value	0.00175202 (rank : 309)
Query Neighborhood Hits	524	Target Neighborhood Hits	963	Shared Neighborhood Hits	135
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHA6_MOUSE
NC score	0.183253 (rank : 393)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	524	Target Neighborhood Hits	946	Shared Neighborhood Hits	153
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FLT3_HUMAN
NC score	0.182492 (rank : 394)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	129
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

PTPRV_MOUSE
NC score	0.181717 (rank : 395)	θ value	0.279714 (rank : 384)
Query Neighborhood Hits	524	Target Neighborhood Hits	179	Shared Neighborhood Hits	81
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

FCG2B_HUMAN
NC score	0.181517 (rank : 396)	θ value	0.0113563 (rank : 330)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	82
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

PTPRJ_MOUSE
NC score	0.181371 (rank : 397)	θ value	0.21417 (rank : 376)
Query Neighborhood Hits	524	Target Neighborhood Hits	188	Shared Neighborhood Hits	91
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

FCG2C_HUMAN
NC score	0.181184 (rank : 398)	θ value	0.0113563 (rank : 331)
Query Neighborhood Hits	524	Target Neighborhood Hits	118	Shared Neighborhood Hits	83
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

CRLF1_HUMAN
NC score	0.179779 (rank : 399)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	524	Target Neighborhood Hits	122	Shared Neighborhood Hits	92
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

PTPRJ_HUMAN
NC score	0.179367 (rank : 400)	θ value	7.1131e-05 (rank : 260)
Query Neighborhood Hits	524	Target Neighborhood Hits	207	Shared Neighborhood Hits	95
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

HCFC2_HUMAN
NC score	0.178611 (rank : 401)	θ value	3.0926 (rank : 434)
Query Neighborhood Hits	524	Target Neighborhood Hits	154	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

SIRB1_HUMAN
NC score	0.171853 (rank : 402)	θ value	1.06291 (rank : 410)
Query Neighborhood Hits	524	Target Neighborhood Hits	422	Shared Neighborhood Hits	134
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

CRLF1_MOUSE
NC score	0.171767 (rank : 403)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

EPHA1_MOUSE
NC score	0.170359 (rank : 404)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	524	Target Neighborhood Hits	958	Shared Neighborhood Hits	145
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

BTNL2_HUMAN
NC score	0.170001 (rank : 405)	θ value	0.21417 (rank : 370)
Query Neighborhood Hits	524	Target Neighborhood Hits	164	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

MOX2R_HUMAN
NC score	0.169048 (rank : 406)	θ value	0.813845 (rank : 402)
Query Neighborhood Hits	524	Target Neighborhood Hits	51	Shared Neighborhood Hits	49
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

IL6RA_MOUSE
NC score	0.168354 (rank : 407)	θ value	0.0193708 (rank : 339)
Query Neighborhood Hits	524	Target Neighborhood Hits	104	Shared Neighborhood Hits	81
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

ICAM3_HUMAN
NC score	0.166365 (rank : 408)	θ value	0.365318 (rank : 388)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

ICAM1_HUMAN
NC score	0.165226 (rank : 409)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	524	Target Neighborhood Hits	80	Shared Neighborhood Hits	72
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

CT075_MOUSE
NC score	0.164968 (rank : 410)	θ value	0.0113563 (rank : 328)
Query Neighborhood Hits	524	Target Neighborhood Hits	358	Shared Neighborhood Hits	100
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

EPHA1_HUMAN
NC score	0.164888 (rank : 411)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	524	Target Neighborhood Hits	997	Shared Neighborhood Hits	138
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

MFAP3_HUMAN
NC score	0.164195 (rank : 412)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	524	Target Neighborhood Hits	91	Shared Neighborhood Hits	82
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

I11RB_MOUSE
NC score	0.162924 (rank : 413)	θ value	0.21417 (rank : 372)
Query Neighborhood Hits	524	Target Neighborhood Hits	101	Shared Neighborhood Hits	70
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

TPSNR_MOUSE
NC score	0.159221 (rank : 414)	θ value	0.813845 (rank : 404)
Query Neighborhood Hits	524	Target Neighborhood Hits	336	Shared Neighborhood Hits	118
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

IGSF2_HUMAN
NC score	0.158214 (rank : 415)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	524	Target Neighborhood Hits	208	Shared Neighborhood Hits	110
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

FCG2A_HUMAN
NC score	0.157331 (rank : 416)	θ value	0.000786445 (rank : 296)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	72
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

ANKF1_HUMAN
NC score	0.156977 (rank : 417)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	524	Target Neighborhood Hits	126	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

CD4_HUMAN
NC score	0.156907 (rank : 418)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	524	Target Neighborhood Hits	122	Shared Neighborhood Hits	81
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

AMGO2_HUMAN
NC score	0.156152 (rank : 419)	θ value	0.0148317 (rank : 335)
Query Neighborhood Hits	524	Target Neighborhood Hits	357	Shared Neighborhood Hits	133
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

I12R1_HUMAN
NC score	0.154177 (rank : 420)	θ value	1.38821 (rank : 413)
Query Neighborhood Hits	524	Target Neighborhood Hits	78	Shared Neighborhood Hits	60
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

I11RA_MOUSE
NC score	0.152107 (rank : 421)	θ value	0.365318 (rank : 387)
Query Neighborhood Hits	524	Target Neighborhood Hits	95	Shared Neighborhood Hits	65
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

PTPRO_HUMAN
NC score	0.151324 (rank : 422)	θ value	5.27518 (rank : 483)
Query Neighborhood Hits	524	Target Neighborhood Hits	139	Shared Neighborhood Hits	60
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

I11RA_HUMAN
NC score	0.151157 (rank : 423)	θ value	1.38821 (rank : 412)
Query Neighborhood Hits	524	Target Neighborhood Hits	138	Shared Neighborhood Hits	72
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

JAML1_HUMAN
NC score	0.150930 (rank : 424)	θ value	0.279714 (rank : 379)
Query Neighborhood Hits	524	Target Neighborhood Hits	108	Shared Neighborhood Hits	75
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

MFAP3_MOUSE
NC score	0.149851 (rank : 425)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

I27RA_HUMAN
NC score	0.149289 (rank : 426)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	524	Target Neighborhood Hits	60	Shared Neighborhood Hits	45
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

RYK_HUMAN
NC score	0.148992 (rank : 427)	θ value	θ > 10 (rank : 1115)
Query Neighborhood Hits	524	Target Neighborhood Hits	701	Shared Neighborhood Hits	81
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
NC score	0.147066 (rank : 428)	θ value	θ > 10 (rank : 1116)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	80
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

RIMB2_HUMAN
NC score	0.145732 (rank : 429)	θ value	θ > 10 (rank : 1097)
Query Neighborhood Hits	524	Target Neighborhood Hits	263	Shared Neighborhood Hits	61
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

LY9_MOUSE
NC score	0.145006 (rank : 430)	θ value	0.21417 (rank : 375)
Query Neighborhood Hits	524	Target Neighborhood Hits	110	Shared Neighborhood Hits	76
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

I12R1_MOUSE
NC score	0.144896 (rank : 431)	θ value	6.88961 (rank : 493)
Query Neighborhood Hits	524	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

LTK_HUMAN
NC score	0.143854 (rank : 432)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	524	Target Neighborhood Hits	774	Shared Neighborhood Hits	85
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

FPRP_HUMAN
NC score	0.143437 (rank : 433)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	524	Target Neighborhood Hits	130	Shared Neighborhood Hits	105
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

LTK_MOUSE
NC score	0.143402 (rank : 434)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	524	Target Neighborhood Hits	770	Shared Neighborhood Hits	83
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

FCRLA_MOUSE
NC score	0.142383 (rank : 435)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	524	Target Neighborhood Hits	110	Shared Neighborhood Hits	65
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

IL6RA_HUMAN
NC score	0.142137 (rank : 436)	θ value	0.00020696 (rank : 277)
Query Neighborhood Hits	524	Target Neighborhood Hits	96	Shared Neighborhood Hits	62
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

ALK_MOUSE
NC score	0.142080 (rank : 437)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	524	Target Neighborhood Hits	811	Shared Neighborhood Hits	91
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_HUMAN
NC score	0.140852 (rank : 438)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	524	Target Neighborhood Hits	795	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

FCRLA_HUMAN
NC score	0.140841 (rank : 439)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	524	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

STYK1_MOUSE
NC score	0.140516 (rank : 440)	θ value	θ > 10 (rank : 1179)
Query Neighborhood Hits	524	Target Neighborhood Hits	779	Shared Neighborhood Hits	84
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

BT3A2_HUMAN
NC score	0.139028 (rank : 441)	θ value	0.62314 (rank : 398)
Query Neighborhood Hits	524	Target Neighborhood Hits	158	Shared Neighborhood Hits	107
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

RET_MOUSE
NC score	0.138918 (rank : 442)	θ value	θ > 10 (rank : 1096)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	87
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

STYK1_HUMAN
NC score	0.138196 (rank : 443)	θ value	θ > 10 (rank : 1178)
Query Neighborhood Hits	524	Target Neighborhood Hits	786	Shared Neighborhood Hits	85
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

RET_HUMAN
NC score	0.138097 (rank : 444)	θ value	θ > 10 (rank : 1095)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

TPSNR_HUMAN
NC score	0.137245 (rank : 445)	θ value	θ > 10 (rank : 1221)
Query Neighborhood Hits	524	Target Neighborhood Hits	330	Shared Neighborhood Hits	106
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

CD48_MOUSE
NC score	0.136950 (rank : 446)	θ value	0.0193708 (rank : 338)
Query Neighborhood Hits	524	Target Neighborhood Hits	96	Shared Neighborhood Hits	64
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

CD226_HUMAN
NC score	0.136833 (rank : 447)	θ value	0.47712 (rank : 393)
Query Neighborhood Hits	524	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

DDR1_MOUSE
NC score	0.135658 (rank : 448)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	524	Target Neighborhood Hits	818	Shared Neighborhood Hits	85
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.135144 (rank : 449)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	524	Target Neighborhood Hits	819	Shared Neighborhood Hits	85
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

RIMB2_MOUSE
NC score	0.134750 (rank : 450)	θ value	θ > 10 (rank : 1098)
Query Neighborhood Hits	524	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CEAMA_MOUSE
NC score	0.133619 (rank : 451)	θ value	8.99809 (rank : 513)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

FPRP_MOUSE
NC score	0.132490 (rank : 452)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	524	Target Neighborhood Hits	116	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

CEAM3_HUMAN
NC score	0.132336 (rank : 453)	θ value	4.03905 (rank : 457)
Query Neighborhood Hits	524	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

DDR2_HUMAN
NC score	0.132201 (rank : 454)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	524	Target Neighborhood Hits	818	Shared Neighborhood Hits	86
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

AMGO2_MOUSE
NC score	0.131805 (rank : 455)	θ value	0.0736092 (rank : 358)
Query Neighborhood Hits	524	Target Neighborhood Hits	329	Shared Neighborhood Hits	106
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

DDR2_MOUSE
NC score	0.131046 (rank : 456)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	524	Target Neighborhood Hits	813	Shared Neighborhood Hits	86
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

SHPS1_MOUSE
NC score	0.130417 (rank : 457)	θ value	0.163984 (rank : 369)
Query Neighborhood Hits	524	Target Neighborhood Hits	439	Shared Neighborhood Hits	129
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

AATK_MOUSE
NC score	0.128810 (rank : 458)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	524	Target Neighborhood Hits	942	Shared Neighborhood Hits	88
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

CD45_MOUSE
NC score	0.128658 (rank : 459)	θ value	0.21417 (rank : 371)
Query Neighborhood Hits	524	Target Neighborhood Hits	178	Shared Neighborhood Hits	50
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

TNK1_HUMAN
NC score	0.128136 (rank : 460)	θ value	θ > 10 (rank : 1215)
Query Neighborhood Hits	524	Target Neighborhood Hits	815	Shared Neighborhood Hits	83
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

CD45_HUMAN
NC score	0.127689 (rank : 461)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	63
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

RON_MOUSE
NC score	0.127069 (rank : 462)	θ value	θ > 10 (rank : 1109)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	82
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

MET_MOUSE
NC score	0.126703 (rank : 463)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	524	Target Neighborhood Hits	844	Shared Neighborhood Hits	83
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_HUMAN
NC score	0.126531 (rank : 464)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	524	Target Neighborhood Hits	831	Shared Neighborhood Hits	83
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

TNK1_MOUSE
NC score	0.125937 (rank : 465)	θ value	θ > 10 (rank : 1216)
Query Neighborhood Hits	524	Target Neighborhood Hits	806	Shared Neighborhood Hits	86
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

FAK2_HUMAN
NC score	0.125779 (rank : 466)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

AMGO3_HUMAN
NC score	0.125343 (rank : 467)	θ value	8.99809 (rank : 509)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	86
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ACK1_MOUSE
NC score	0.125319 (rank : 468)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	524	Target Neighborhood Hits	1080	Shared Neighborhood Hits	90
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

RON_HUMAN
NC score	0.125210 (rank : 469)	θ value	θ > 10 (rank : 1108)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	82
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

AATK_HUMAN
NC score	0.125134 (rank : 470)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	524	Target Neighborhood Hits	1243	Shared Neighborhood Hits	89
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

FAK1_HUMAN
NC score	0.125103 (rank : 471)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK2_MOUSE
NC score	0.125057 (rank : 472)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK1_MOUSE
NC score	0.124792 (rank : 473)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

ACK1_HUMAN
NC score	0.124101 (rank : 474)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	524	Target Neighborhood Hits	1140	Shared Neighborhood Hits	89
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ERBB3_HUMAN
NC score	0.123775 (rank : 475)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	524	Target Neighborhood Hits	918	Shared Neighborhood Hits	85
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB2_HUMAN
NC score	0.122596 (rank : 476)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	524	Target Neighborhood Hits	1073	Shared Neighborhood Hits	90
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB3_MOUSE
NC score	0.122463 (rank : 477)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	524	Target Neighborhood Hits	898	Shared Neighborhood Hits	84
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB2_MOUSE
NC score	0.122308 (rank : 478)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	524	Target Neighborhood Hits	918	Shared Neighborhood Hits	87
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB4_HUMAN
NC score	0.121887 (rank : 479)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	524	Target Neighborhood Hits	910	Shared Neighborhood Hits	91
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ZAP70_MOUSE
NC score	0.121117 (rank : 480)	θ value	θ > 10 (rank : 1250)
Query Neighborhood Hits	524	Target Neighborhood Hits	905	Shared Neighborhood Hits	83
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

EGFR_MOUSE
NC score	0.121106 (rank : 481)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	524	Target Neighborhood Hits	927	Shared Neighborhood Hits	90
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

KSYK_HUMAN
NC score	0.121027 (rank : 482)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	524	Target Neighborhood Hits	901	Shared Neighborhood Hits	83
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
NC score	0.120863 (rank : 483)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	524	Target Neighborhood Hits	944	Shared Neighborhood Hits	84
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

AMGO1_HUMAN
NC score	0.120707 (rank : 484)	θ value	1.06291 (rank : 405)
Query Neighborhood Hits	524	Target Neighborhood Hits	353	Shared Neighborhood Hits	111
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

EGFR_HUMAN
NC score	0.120645 (rank : 485)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	524	Target Neighborhood Hits	939	Shared Neighborhood Hits	87
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

AMGO3_MOUSE
NC score	0.119878 (rank : 486)	θ value	0.62314 (rank : 397)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ZAP70_HUMAN
NC score	0.119786 (rank : 487)	θ value	θ > 10 (rank : 1249)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	83
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SRMS_HUMAN
NC score	0.119130 (rank : 488)	θ value	θ > 10 (rank : 1153)
Query Neighborhood Hits	524	Target Neighborhood Hits	946	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FES_HUMAN
NC score	0.118752 (rank : 489)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	524	Target Neighborhood Hits	978	Shared Neighborhood Hits	83
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
NC score	0.118630 (rank : 490)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	83
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SIRPG_HUMAN
NC score	0.117973 (rank : 491)	θ value	θ > 10 (rank : 1122)
Query Neighborhood Hits	524	Target Neighborhood Hits	359	Shared Neighborhood Hits	110
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

SRMS_MOUSE
NC score	0.117884 (rank : 492)	θ value	θ > 10 (rank : 1154)
Query Neighborhood Hits	524	Target Neighborhood Hits	964	Shared Neighborhood Hits	83
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BT1A1_MOUSE
NC score	0.117334 (rank : 493)	θ value	0.47712 (rank : 391)
Query Neighborhood Hits	524	Target Neighborhood Hits	252	Shared Neighborhood Hits	131
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

MATK_HUMAN
NC score	0.117301 (rank : 494)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	524	Target Neighborhood Hits	954	Shared Neighborhood Hits	84
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

CD48_HUMAN
NC score	0.117264 (rank : 495)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	524	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

LEPR_MOUSE
NC score	0.117231 (rank : 496)	θ value	0.0736092 (rank : 361)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	66
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

MATK_MOUSE
NC score	0.116545 (rank : 497)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	524	Target Neighborhood Hits	952	Shared Neighborhood Hits	84
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

FER_HUMAN
NC score	0.115961 (rank : 498)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	524	Target Neighborhood Hits	1278	Shared Neighborhood Hits	84
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

LEPR_HUMAN
NC score	0.115959 (rank : 499)	θ value	0.279714 (rank : 380)
Query Neighborhood Hits	524	Target Neighborhood Hits	112	Shared Neighborhood Hits	67
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

BMX_MOUSE
NC score	0.114557 (rank : 500)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	524	Target Neighborhood Hits	912	Shared Neighborhood Hits	86
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ICOSL_MOUSE
NC score	0.114166 (rank : 501)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

IL27B_MOUSE
NC score	0.113960 (rank : 502)	θ value	0.0252991 (rank : 344)
Query Neighborhood Hits	524	Target Neighborhood Hits	55	Shared Neighborhood Hits	40
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

BMX_HUMAN
NC score	0.113551 (rank : 503)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	524	Target Neighborhood Hits	942	Shared Neighborhood Hits	85
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

I18RA_HUMAN
NC score	0.113377 (rank : 504)	θ value	0.0961366 (rank : 364)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	68
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

TXK_MOUSE
NC score	0.113340 (rank : 505)	θ value	θ > 10 (rank : 1232)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	84
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ABL1_MOUSE
NC score	0.113043 (rank : 506)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	524	Target Neighborhood Hits	1178	Shared Neighborhood Hits	91
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
NC score	0.112957 (rank : 507)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	524	Target Neighborhood Hits	1045	Shared Neighborhood Hits	85
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

HCK_MOUSE
NC score	0.112846 (rank : 508)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	524	Target Neighborhood Hits	1029	Shared Neighborhood Hits	84
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

PTK6_MOUSE
NC score	0.112682 (rank : 509)	θ value	θ > 10 (rank : 1044)
Query Neighborhood Hits	524	Target Neighborhood Hits	1026	Shared Neighborhood Hits	84
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ABL1_HUMAN
NC score	0.112677 (rank : 510)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	524	Target Neighborhood Hits	1220	Shared Neighborhood Hits	87
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

HCK_HUMAN
NC score	0.112454 (rank : 511)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	524	Target Neighborhood Hits	1035	Shared Neighborhood Hits	85
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

TXK_HUMAN
NC score	0.112267 (rank : 512)	θ value	θ > 10 (rank : 1231)
Query Neighborhood Hits	524	Target Neighborhood Hits	971	Shared Neighborhood Hits	84
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ITK_MOUSE
NC score	0.112158 (rank : 513)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	524	Target Neighborhood Hits	985	Shared Neighborhood Hits	84
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LCK_HUMAN
NC score	0.112092 (rank : 514)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	524	Target Neighborhood Hits	987	Shared Neighborhood Hits	85
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BLK_MOUSE
NC score	0.112011 (rank : 515)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	524	Target Neighborhood Hits	992	Shared Neighborhood Hits	83
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FRK_HUMAN
NC score	0.111899 (rank : 516)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	524	Target Neighborhood Hits	1058	Shared Neighborhood Hits	84
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

BTK_HUMAN
NC score	0.111651 (rank : 517)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	524	Target Neighborhood Hits	1026	Shared Neighborhood Hits	86
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

LCK_MOUSE
NC score	0.111585 (rank : 518)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	524	Target Neighborhood Hits	981	Shared Neighborhood Hits	83
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BTK_MOUSE
NC score	0.111558 (rank : 519)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	524	Target Neighborhood Hits	1017	Shared Neighborhood Hits	86
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ITK_HUMAN
NC score	0.111533 (rank : 520)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	524	Target Neighborhood Hits	1016	Shared Neighborhood Hits	85
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TEC_HUMAN
NC score	0.111502 (rank : 521)	θ value	θ > 10 (rank : 1185)
Query Neighborhood Hits	524	Target Neighborhood Hits	1006	Shared Neighborhood Hits	85
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CSK_HUMAN
NC score	0.111327 (rank : 522)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

TEC_MOUSE
NC score	0.110999 (rank : 523)	θ value	θ > 10 (rank : 1186)
Query Neighborhood Hits	524	Target Neighborhood Hits	1006	Shared Neighborhood Hits	83
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BLK_HUMAN
NC score	0.110971 (rank : 524)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	524	Target Neighborhood Hits	994	Shared Neighborhood Hits	84
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CD244_HUMAN
NC score	0.110732 (rank : 525)	θ value	0.62314 (rank : 399)
Query Neighborhood Hits	524	Target Neighborhood Hits	72	Shared Neighborhood Hits	45
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

SIGIR_MOUSE
NC score	0.110704 (rank : 526)	θ value	2.36792 (rank : 432)
Query Neighborhood Hits	524	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

JAK1_HUMAN
NC score	0.110600 (rank : 527)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
NC score	0.110528 (rank : 528)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	83
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

HCFC1_MOUSE
NC score	0.110454 (rank : 529)	θ value	6.88961 (rank : 492)
Query Neighborhood Hits	524	Target Neighborhood Hits	348	Shared Neighborhood Hits	66
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

LYN_MOUSE
NC score	0.110336 (rank : 530)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	524	Target Neighborhood Hits	1023	Shared Neighborhood Hits	84
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BTNL1_MOUSE
NC score	0.110249 (rank : 531)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	524	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

JAK3_HUMAN
NC score	0.110201 (rank : 532)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	524	Target Neighborhood Hits	827	Shared Neighborhood Hits	83
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

LYN_HUMAN
NC score	0.110168 (rank : 533)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	524	Target Neighborhood Hits	1022	Shared Neighborhood Hits	85
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.109919 (rank : 534)	θ value	θ > 10 (rank : 1043)
Query Neighborhood Hits	524	Target Neighborhood Hits	1020	Shared Neighborhood Hits	84
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

BT1A1_HUMAN
NC score	0.109534 (rank : 535)	θ value	0.0736092 (rank : 359)
Query Neighborhood Hits	524	Target Neighborhood Hits	322	Shared Neighborhood Hits	128
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

CSK_MOUSE
NC score	0.109443 (rank : 536)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

FGR_MOUSE
NC score	0.109411 (rank : 537)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	524	Target Neighborhood Hits	1069	Shared Neighborhood Hits	84
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_HUMAN
NC score	0.109370 (rank : 538)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	524	Target Neighborhood Hits	1067	Shared Neighborhood Hits	84
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_MOUSE
NC score	0.109172 (rank : 539)	θ value	θ > 10 (rank : 1150)
Query Neighborhood Hits	524	Target Neighborhood Hits	1033	Shared Neighborhood Hits	84
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SIGL9_HUMAN
NC score	0.109062 (rank : 540)	θ value	θ > 10 (rank : 1121)
Query Neighborhood Hits	524	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

YES_HUMAN
NC score	0.109016 (rank : 541)	θ value	θ > 10 (rank : 1246)
Query Neighborhood Hits	524	Target Neighborhood Hits	1059	Shared Neighborhood Hits	85
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.108912 (rank : 542)	θ value	θ > 10 (rank : 1247)
Query Neighborhood Hits	524	Target Neighborhood Hits	1052	Shared Neighborhood Hits	84
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SRC_HUMAN
NC score	0.108427 (rank : 543)	θ value	θ > 10 (rank : 1149)
Query Neighborhood Hits	524	Target Neighborhood Hits	1058	Shared Neighborhood Hits	84
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

I18RA_MOUSE
NC score	0.108402 (rank : 544)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

JAK2_HUMAN
NC score	0.108313 (rank : 545)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
NC score	0.108255 (rank : 546)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	83
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

IL1AP_MOUSE
NC score	0.108157 (rank : 547)	θ value	4.03905 (rank : 459)
Query Neighborhood Hits	524	Target Neighborhood Hits	94	Shared Neighborhood Hits	60
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

FCG3B_HUMAN
NC score	0.107522 (rank : 548)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	524	Target Neighborhood Hits	67	Shared Neighborhood Hits	53
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

TYK2_MOUSE
NC score	0.107499 (rank : 549)	θ value	θ > 10 (rank : 1234)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

FYN_MOUSE
NC score	0.107027 (rank : 550)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	524	Target Neighborhood Hits	1073	Shared Neighborhood Hits	84
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

TYK2_HUMAN
NC score	0.106702 (rank : 551)	θ value	θ > 10 (rank : 1233)
Query Neighborhood Hits	524	Target Neighborhood Hits	841	Shared Neighborhood Hits	83
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_MOUSE
NC score	0.106496 (rank : 552)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

PTPRG_HUMAN
NC score	0.106400 (rank : 553)	θ value	θ > 10 (rank : 1081)
Query Neighborhood Hits	524	Target Neighborhood Hits	231	Shared Neighborhood Hits	58
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

FYN_HUMAN
NC score	0.106223 (rank : 554)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	524	Target Neighborhood Hits	1078	Shared Neighborhood Hits	84
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

PTPRG_MOUSE
NC score	0.105250 (rank : 555)	θ value	θ > 10 (rank : 1082)
Query Neighborhood Hits	524	Target Neighborhood Hits	260	Shared Neighborhood Hits	58
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRZ_HUMAN
NC score	0.103782 (rank : 556)	θ value	θ > 10 (rank : 1087)
Query Neighborhood Hits	524	Target Neighborhood Hits	255	Shared Neighborhood Hits	42
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

GP116_HUMAN
NC score	0.103563 (rank : 557)	θ value	0.0252991 (rank : 342)
Query Neighborhood Hits	524	Target Neighborhood Hits	167	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

PTPRE_MOUSE
NC score	0.103044 (rank : 558)	θ value	θ > 10 (rank : 1080)
Query Neighborhood Hits	524	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_HUMAN
NC score	0.102904 (rank : 559)	θ value	θ > 10 (rank : 1077)
Query Neighborhood Hits	524	Target Neighborhood Hits	101	Shared Neighborhood Hits	18
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRE_HUMAN
NC score	0.102778 (rank : 560)	θ value	θ > 10 (rank : 1079)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	17
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_MOUSE
NC score	0.102411 (rank : 561)	θ value	θ > 10 (rank : 1078)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

AMGO1_MOUSE
NC score	0.100736 (rank : 562)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	524	Target Neighborhood Hits	325	Shared Neighborhood Hits	89
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

LRRK1_MOUSE
NC score	0.099177 (rank : 563)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	524	Target Neighborhood Hits	1267	Shared Neighborhood Hits	121
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

GUC2C_HUMAN
NC score	0.096969 (rank : 564)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	524	Target Neighborhood Hits	624	Shared Neighborhood Hits	78
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

M3KL4_HUMAN
NC score	0.096936 (rank : 565)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	524	Target Neighborhood Hits	1087	Shared Neighborhood Hits	85
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CNTFR_MOUSE
NC score	0.096776 (rank : 566)	θ value	0.0563607 (rank : 353)
Query Neighborhood Hits	524	Target Neighborhood Hits	74	Shared Neighborhood Hits	49
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

LRRK1_HUMAN
NC score	0.096659 (rank : 567)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	524	Target Neighborhood Hits	1237	Shared Neighborhood Hits	120
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

CD86_MOUSE
NC score	0.096428 (rank : 568)	θ value	4.03905 (rank : 456)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	P42082	Gene names	Cd86
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (Early T-cell costimulatory molecule 1) (ETC-1).

I27RA_MOUSE
NC score	0.096261 (rank : 569)	θ value	3.0926 (rank : 435)
Query Neighborhood Hits	524	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

MLTK_MOUSE
NC score	0.095358 (rank : 570)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

FCG3A_HUMAN
NC score	0.095298 (rank : 571)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	524	Target Neighborhood Hits	65	Shared Neighborhood Hits	51
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

MLTK_HUMAN
NC score	0.095158 (rank : 572)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

FCGR2_MOUSE
NC score	0.094813 (rank : 573)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	524	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

MLKL_HUMAN
NC score	0.094687 (rank : 574)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	524	Target Neighborhood Hits	600	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

GUC2F_HUMAN
NC score	0.094462 (rank : 575)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	524	Target Neighborhood Hits	740	Shared Neighborhood Hits	82
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

IL1AP_HUMAN
NC score	0.094011 (rank : 576)	θ value	0.365318 (rank : 389)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

CD226_MOUSE
NC score	0.093960 (rank : 577)	θ value	4.03905 (rank : 455)
Query Neighborhood Hits	524	Target Neighborhood Hits	64	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K4F0	Gene names	Cd226, Pta1
Domain Architecture
Description	CD226 antigen precursor (Platelet and T-cell activation antigen 1).

M3K12_MOUSE
NC score	0.093942 (rank : 578)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	524	Target Neighborhood Hits	957	Shared Neighborhood Hits	85
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
NC score	0.093851 (rank : 579)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	524	Target Neighborhood Hits	940	Shared Neighborhood Hits	84
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K9_HUMAN
NC score	0.092953 (rank : 580)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	524	Target Neighborhood Hits	1123	Shared Neighborhood Hits	86
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.092873 (rank : 581)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	524	Target Neighborhood Hits	1071	Shared Neighborhood Hits	87
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
NC score	0.092500 (rank : 582)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	524	Target Neighborhood Hits	1136	Shared Neighborhood Hits	89
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

A1BG_HUMAN
NC score	0.092395 (rank : 583)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	524	Target Neighborhood Hits	94	Shared Neighborhood Hits	48
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

M3K13_HUMAN
NC score	0.091827 (rank : 584)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	84
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

FCERA_MOUSE
NC score	0.091183 (rank : 585)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	524	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

GP125_MOUSE
NC score	0.090879 (rank : 586)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	524	Target Neighborhood Hits	329	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

ARAF_MOUSE
NC score	0.090671 (rank : 587)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

CNTFR_HUMAN
NC score	0.090575 (rank : 588)	θ value	0.47712 (rank : 394)
Query Neighborhood Hits	524	Target Neighborhood Hits	66	Shared Neighborhood Hits	42
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

BRAF1_HUMAN
NC score	0.090542 (rank : 589)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	524	Target Neighborhood Hits	883	Shared Neighborhood Hits	85
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

ARAF_HUMAN
NC score	0.090347 (rank : 590)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	524	Target Neighborhood Hits	924	Shared Neighborhood Hits	85
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

TESK2_HUMAN
NC score	0.090214 (rank : 591)	θ value	θ > 10 (rank : 1189)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
NC score	0.090115 (rank : 592)	θ value	θ > 10 (rank : 1190)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

RAF1_MOUSE
NC score	0.090103 (rank : 593)	θ value	θ > 10 (rank : 1094)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	84
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MLKL_MOUSE
NC score	0.090044 (rank : 594)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	524	Target Neighborhood Hits	707	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

RAF1_HUMAN
NC score	0.089340 (rank : 595)	θ value	θ > 10 (rank : 1093)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

GP125_HUMAN
NC score	0.089260 (rank : 596)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	524	Target Neighborhood Hits	327	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

IGSF8_HUMAN
NC score	0.089019 (rank : 597)	θ value	2.36792 (rank : 427)
Query Neighborhood Hits	524	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

MOS_HUMAN
NC score	0.088731 (rank : 598)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	83
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

LY9_HUMAN
NC score	0.088451 (rank : 599)	θ value	1.81305 (rank : 424)
Query Neighborhood Hits	524	Target Neighborhood Hits	82	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

RIPK1_MOUSE
NC score	0.088188 (rank : 600)	θ value	θ > 10 (rank : 1100)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

M3K7_MOUSE
NC score	0.088173 (rank : 601)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	524	Target Neighborhood Hits	892	Shared Neighborhood Hits	83
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.088160 (rank : 602)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	524	Target Neighborhood Hits	892	Shared Neighborhood Hits	83
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

RIPK1_HUMAN
NC score	0.087433 (rank : 603)	θ value	θ > 10 (rank : 1099)
Query Neighborhood Hits	524	Target Neighborhood Hits	891	Shared Neighborhood Hits	84
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ILK_MOUSE
NC score	0.087234 (rank : 604)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	81
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.086763 (rank : 605)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	81
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

KSR1_HUMAN
NC score	0.086724 (rank : 606)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
NC score	0.086632 (rank : 607)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	524	Target Neighborhood Hits	870	Shared Neighborhood Hits	86
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MOS_MOUSE
NC score	0.085585 (rank : 608)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

LRRK2_HUMAN
NC score	0.085467 (rank : 609)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	524	Target Neighborhood Hits	1382	Shared Neighborhood Hits	115
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

HCFC1_HUMAN
NC score	0.085086 (rank : 610)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	524	Target Neighborhood Hits	331	Shared Neighborhood Hits	52
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

TMM25_MOUSE
NC score	0.084759 (rank : 611)	θ value	θ > 10 (rank : 1211)
Query Neighborhood Hits	524	Target Neighborhood Hits	46	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

ILK2_HUMAN
NC score	0.084421 (rank : 612)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	524	Target Neighborhood Hits	848	Shared Neighborhood Hits	81
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

TESK1_MOUSE
NC score	0.084329 (rank : 613)	θ value	θ > 10 (rank : 1188)
Query Neighborhood Hits	524	Target Neighborhood Hits	862	Shared Neighborhood Hits	85
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

BT3A3_HUMAN
NC score	0.084239 (rank : 614)	θ value	1.06291 (rank : 406)
Query Neighborhood Hits	524	Target Neighborhood Hits	233	Shared Neighborhood Hits	113
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

LRRK2_MOUSE
NC score	0.083933 (rank : 615)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	524	Target Neighborhood Hits	1359	Shared Neighborhood Hits	115
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
NC score	0.083746 (rank : 616)	θ value	θ > 10 (rank : 1103)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

TESK1_HUMAN
NC score	0.083496 (rank : 617)	θ value	θ > 10 (rank : 1187)
Query Neighborhood Hits	524	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

LIMK1_HUMAN
NC score	0.083258 (rank : 618)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	524	Target Neighborhood Hits	1005	Shared Neighborhood Hits	83
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.083185 (rank : 619)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	524	Target Neighborhood Hits	1008	Shared Neighborhood Hits	84
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

BT3A1_HUMAN
NC score	0.083178 (rank : 620)	θ value	0.47712 (rank : 392)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	107
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

IGSF8_MOUSE
NC score	0.082966 (rank : 621)	θ value	1.81305 (rank : 422)
Query Neighborhood Hits	524	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

RIPK5_MOUSE
NC score	0.082847 (rank : 622)	θ value	θ > 10 (rank : 1107)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RIPK5_HUMAN
NC score	0.082767 (rank : 623)	θ value	θ > 10 (rank : 1106)
Query Neighborhood Hits	524	Target Neighborhood Hits	864	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK2_MOUSE
NC score	0.082528 (rank : 624)	θ value	θ > 10 (rank : 1102)
Query Neighborhood Hits	524	Target Neighborhood Hits	776	Shared Neighborhood Hits	82
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

CD86_HUMAN
NC score	0.082502 (rank : 625)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	P42081, Q13655, Q7M4L5	Gene names	CD86, CD28LG2
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63).

IRAK4_HUMAN
NC score	0.081945 (rank : 626)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	524	Target Neighborhood Hits	816	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

TOPK_MOUSE
NC score	0.081755 (rank : 627)	θ value	θ > 10 (rank : 1218)
Query Neighborhood Hits	524	Target Neighborhood Hits	618	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

LIMK2_HUMAN
NC score	0.081738 (rank : 628)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	524	Target Neighborhood Hits	986	Shared Neighborhood Hits	83
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
NC score	0.081595 (rank : 629)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	524	Target Neighborhood Hits	998	Shared Neighborhood Hits	83
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

PTN9_MOUSE
NC score	0.081568 (rank : 630)	θ value	θ > 10 (rank : 1074)
Query Neighborhood Hits	524	Target Neighborhood Hits	78	Shared Neighborhood Hits	17
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_HUMAN
NC score	0.081301 (rank : 631)	θ value	θ > 10 (rank : 1073)
Query Neighborhood Hits	524	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

ICOSL_HUMAN
NC score	0.081289 (rank : 632)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	524	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

PTN7_MOUSE
NC score	0.081178 (rank : 633)	θ value	θ > 10 (rank : 1072)
Query Neighborhood Hits	524	Target Neighborhood Hits	71	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN5_MOUSE
NC score	0.081113 (rank : 634)	θ value	θ > 10 (rank : 1068)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_HUMAN
NC score	0.081106 (rank : 635)	θ value	θ > 10 (rank : 1067)
Query Neighborhood Hits	524	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN7_HUMAN
NC score	0.081081 (rank : 636)	θ value	θ > 10 (rank : 1071)
Query Neighborhood Hits	524	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTPRN_MOUSE
NC score	0.080642 (rank : 637)	θ value	θ > 10 (rank : 1084)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	24
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

CEA19_HUMAN
NC score	0.080428 (rank : 638)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	524	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

PTN2_HUMAN
NC score	0.080363 (rank : 639)	θ value	θ > 10 (rank : 1063)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	17
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

TOPK_HUMAN
NC score	0.080099 (rank : 640)	θ value	θ > 10 (rank : 1217)
Query Neighborhood Hits	524	Target Neighborhood Hits	605	Shared Neighborhood Hits	73
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

IRAK4_MOUSE
NC score	0.080053 (rank : 641)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	524	Target Neighborhood Hits	820	Shared Neighborhood Hits	84
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

PTPRN_HUMAN
NC score	0.079999 (rank : 642)	θ value	θ > 10 (rank : 1083)
Query Neighborhood Hits	524	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

FCGR3_MOUSE
NC score	0.079929 (rank : 643)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	524	Target Neighborhood Hits	98	Shared Neighborhood Hits	46
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

GUC2E_MOUSE
NC score	0.079878 (rank : 644)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	524	Target Neighborhood Hits	692	Shared Neighborhood Hits	81
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

PTPR2_MOUSE
NC score	0.079863 (rank : 645)	θ value	θ > 10 (rank : 1076)
Query Neighborhood Hits	524	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTN2_MOUSE
NC score	0.079808 (rank : 646)	θ value	θ > 10 (rank : 1064)
Query Neighborhood Hits	524	Target Neighborhood Hits	107	Shared Neighborhood Hits	17
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

TMM25_HUMAN
NC score	0.079757 (rank : 647)	θ value	θ > 10 (rank : 1210)
Query Neighborhood Hits	524	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

VASN_MOUSE
NC score	0.079578 (rank : 648)	θ value	θ > 10 (rank : 1244)
Query Neighborhood Hits	524	Target Neighborhood Hits	426	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

PTPR2_HUMAN
NC score	0.079439 (rank : 649)	θ value	θ > 10 (rank : 1075)
Query Neighborhood Hits	524	Target Neighborhood Hits	103	Shared Neighborhood Hits	18
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

IRAK3_MOUSE
NC score	0.079404 (rank : 650)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	524	Target Neighborhood Hits	628	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

PTPRR_MOUSE
NC score	0.079203 (rank : 651)	θ value	θ > 10 (rank : 1086)
Query Neighborhood Hits	524	Target Neighborhood Hits	84	Shared Neighborhood Hits	18
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRR_HUMAN
NC score	0.079187 (rank : 652)	θ value	θ > 10 (rank : 1085)
Query Neighborhood Hits	524	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTN1_HUMAN
NC score	0.079097 (rank : 653)	θ value	θ > 10 (rank : 1055)
Query Neighborhood Hits	524	Target Neighborhood Hits	84	Shared Neighborhood Hits	17
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
NC score	0.078967 (rank : 654)	θ value	θ > 10 (rank : 1056)
Query Neighborhood Hits	524	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

RIPK2_HUMAN
NC score	0.078841 (rank : 655)	θ value	θ > 10 (rank : 1101)
Query Neighborhood Hits	524	Target Neighborhood Hits	774	Shared Neighborhood Hits	81
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

PTN22_HUMAN
NC score	0.078775 (rank : 656)	θ value	θ > 10 (rank : 1059)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

FLRT1_HUMAN
NC score	0.078595 (rank : 657)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	524	Target Neighborhood Hits	286	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZU1	Gene names	FLRT1
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT1 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 1).

VASN_HUMAN
NC score	0.078361 (rank : 658)	θ value	θ > 10 (rank : 1243)
Query Neighborhood Hits	524	Target Neighborhood Hits	449	Shared Neighborhood Hits	62
SwissProt Accessions	Q6EMK4, Q6UXL4, Q6UXL5, Q96CX1	Gene names	VASN, SLITL2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

PTN18_MOUSE
NC score	0.078067 (rank : 659)	θ value	θ > 10 (rank : 1054)
Query Neighborhood Hits	524	Target Neighborhood Hits	134	Shared Neighborhood Hits	18
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

SLAF9_MOUSE
NC score	0.078036 (rank : 660)	θ value	θ > 10 (rank : 1126)
Query Neighborhood Hits	524	Target Neighborhood Hits	78	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D780, Q8BTK0, Q8VE93	Gene names	Slamf9
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor.

IL18R_MOUSE
NC score	0.077677 (rank : 661)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	524	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

SLIT2_HUMAN
NC score	0.077514 (rank : 662)	θ value	θ > 10 (rank : 1139)
Query Neighborhood Hits	524	Target Neighborhood Hits	708	Shared Neighborhood Hits	67
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

KSR2_HUMAN
NC score	0.077403 (rank : 663)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	524	Target Neighborhood Hits	920	Shared Neighborhood Hits	85
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

PTN18_HUMAN
NC score	0.077389 (rank : 664)	θ value	θ > 10 (rank : 1053)
Query Neighborhood Hits	524	Target Neighborhood Hits	73	Shared Neighborhood Hits	17
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

FLRT3_HUMAN
NC score	0.077306 (rank : 665)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	524	Target Neighborhood Hits	281	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

PTN12_HUMAN
NC score	0.077148 (rank : 666)	θ value	θ > 10 (rank : 1047)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

TEX14_HUMAN
NC score	0.076902 (rank : 667)	θ value	θ > 10 (rank : 1191)
Query Neighborhood Hits	524	Target Neighborhood Hits	1103	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
NC score	0.076785 (rank : 668)	θ value	θ > 10 (rank : 1192)
Query Neighborhood Hits	524	Target Neighborhood Hits	1333	Shared Neighborhood Hits	82
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

PTN22_MOUSE
NC score	0.076751 (rank : 669)	θ value	θ > 10 (rank : 1060)
Query Neighborhood Hits	524	Target Neighborhood Hits	179	Shared Neighborhood Hits	24
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

SLIT2_MOUSE
NC score	0.076741 (rank : 670)	θ value	θ > 10 (rank : 1140)
Query Neighborhood Hits	524	Target Neighborhood Hits	684	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

PTN12_MOUSE
NC score	0.076693 (rank : 671)	θ value	θ > 10 (rank : 1048)
Query Neighborhood Hits	524	Target Neighborhood Hits	123	Shared Neighborhood Hits	18
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

SLIT1_MOUSE
NC score	0.075727 (rank : 672)	θ value	θ > 10 (rank : 1138)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	66
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

ANPRA_HUMAN
NC score	0.075243 (rank : 673)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	524	Target Neighborhood Hits	612	Shared Neighborhood Hits	77
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

GUC2D_HUMAN
NC score	0.075151 (rank : 674)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	82
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
NC score	0.074889 (rank : 675)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	524	Target Neighborhood Hits	644	Shared Neighborhood Hits	77
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

SLIT3_MOUSE
NC score	0.074659 (rank : 676)	θ value	θ > 10 (rank : 1142)
Query Neighborhood Hits	524	Target Neighborhood Hits	700	Shared Neighborhood Hits	65
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SLIT3_HUMAN
NC score	0.074629 (rank : 677)	θ value	θ > 10 (rank : 1141)
Query Neighborhood Hits	524	Target Neighborhood Hits	682	Shared Neighborhood Hits	65
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

ANPRA_MOUSE
NC score	0.074624 (rank : 678)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	524	Target Neighborhood Hits	600	Shared Neighborhood Hits	77
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

NYX_MOUSE
NC score	0.074008 (rank : 679)	θ value	θ > 10 (rank : 983)
Query Neighborhood Hits	524	Target Neighborhood Hits	241	Shared Neighborhood Hits	42
SwissProt Accessions	P83503, Q8BYN4	Gene names	Nyx
Domain Architecture
Description	Nyctalopin precursor.

SLIT1_HUMAN
NC score	0.073664 (rank : 680)	θ value	θ > 10 (rank : 1137)
Query Neighborhood Hits	524	Target Neighborhood Hits	700	Shared Neighborhood Hits	65
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

CHAD_HUMAN
NC score	0.073522 (rank : 681)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	42
SwissProt Accessions	O15335, Q96RJ5	Gene names	CHAD
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

SLAF8_MOUSE
NC score	0.073331 (rank : 682)	θ value	θ > 10 (rank : 1125)
Query Neighborhood Hits	524	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D3G2, Q8R3T7	Gene names	Slamf8, Blame
Domain Architecture	No domain graphic available
Description	SLAM family member 8 precursor (B-lymphocyte activator macrophage expressed).

NYX_HUMAN
NC score	0.073236 (rank : 683)	θ value	θ > 10 (rank : 982)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q9GZU5, Q5H983, Q9H4J0	Gene names	NYX, CLRP
Domain Architecture
Description	Nyctalopin precursor.

TNI3K_MOUSE
NC score	0.073028 (rank : 684)	θ value	θ > 10 (rank : 1213)
Query Neighborhood Hits	524	Target Neighborhood Hits	1079	Shared Neighborhood Hits	81
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

PTN6_HUMAN
NC score	0.072843 (rank : 685)	θ value	θ > 10 (rank : 1069)
Query Neighborhood Hits	524	Target Neighborhood Hits	234	Shared Neighborhood Hits	20
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
NC score	0.072694 (rank : 686)	θ value	θ > 10 (rank : 1070)
Query Neighborhood Hits	524	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

IRAK3_HUMAN
NC score	0.072666 (rank : 687)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	524	Target Neighborhood Hits	644	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

FLRT2_HUMAN
NC score	0.072020 (rank : 688)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	49
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

SLAF5_MOUSE
NC score	0.071950 (rank : 689)	θ value	θ > 10 (rank : 1124)
Query Neighborhood Hits	524	Target Neighborhood Hits	93	Shared Neighborhood Hits	54
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

ACVL1_MOUSE
NC score	0.071915 (rank : 690)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	524	Target Neighborhood Hits	739	Shared Neighborhood Hits	77
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TNI3K_HUMAN
NC score	0.071889 (rank : 691)	θ value	θ > 10 (rank : 1212)
Query Neighborhood Hits	524	Target Neighborhood Hits	1084	Shared Neighborhood Hits	80
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CHAD_MOUSE
NC score	0.071544 (rank : 692)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	524	Target Neighborhood Hits	260	Shared Neighborhood Hits	42
SwissProt Accessions	O55226	Gene names	Chad
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

R4RL2_HUMAN
NC score	0.071452 (rank : 693)	θ value	θ > 10 (rank : 1091)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	41
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

R4RL2_MOUSE
NC score	0.071433 (rank : 694)	θ value	θ > 10 (rank : 1092)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

LRC15_MOUSE
NC score	0.071330 (rank : 695)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	42
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

ALS_HUMAN
NC score	0.070898 (rank : 696)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	524	Target Neighborhood Hits	280	Shared Neighborhood Hits	43
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

CD79B_MOUSE
NC score	0.070665 (rank : 697)	θ value	1.81305 (rank : 420)
Query Neighborhood Hits	524	Target Neighborhood Hits	150	Shared Neighborhood Hits	51
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

PTN11_HUMAN
NC score	0.070614 (rank : 698)	θ value	θ > 10 (rank : 1045)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
NC score	0.070609 (rank : 699)	θ value	θ > 10 (rank : 1046)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

TSK_HUMAN
NC score	0.070603 (rank : 700)	θ value	θ > 10 (rank : 1223)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

IKKA_HUMAN
NC score	0.070487 (rank : 701)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	524	Target Neighborhood Hits	863	Shared Neighborhood Hits	83
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
NC score	0.070386 (rank : 702)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

ANPRB_HUMAN
NC score	0.070279 (rank : 703)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	524	Target Neighborhood Hits	646	Shared Neighborhood Hits	77
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

NEK11_MOUSE
NC score	0.070121 (rank : 704)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	524	Target Neighborhood Hits	875	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TRIM9_HUMAN
NC score	0.069878 (rank : 705)	θ value	θ > 10 (rank : 1222)
Query Neighborhood Hits	524	Target Neighborhood Hits	294	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

PRLR_HUMAN
NC score	0.069816 (rank : 706)	θ value	θ > 10 (rank : 1041)
Query Neighborhood Hits	524	Target Neighborhood Hits	95	Shared Neighborhood Hits	51
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_MOUSE
NC score	0.069717 (rank : 707)	θ value	θ > 10 (rank : 1042)
Query Neighborhood Hits	524	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

IRAK1_MOUSE
NC score	0.069430 (rank : 708)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	524	Target Neighborhood Hits	784	Shared Neighborhood Hits	84
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

GPV_MOUSE
NC score	0.069425 (rank : 709)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	41
SwissProt Accessions	O08742	Gene names	Gp5
Domain Architecture	No domain graphic available
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

ANPRB_MOUSE
NC score	0.069272 (rank : 710)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	524	Target Neighborhood Hits	607	Shared Neighborhood Hits	77
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

RTN4R_HUMAN
NC score	0.069270 (rank : 711)	θ value	θ > 10 (rank : 1110)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

TGFR2_HUMAN
NC score	0.069246 (rank : 712)	θ value	θ > 10 (rank : 1195)
Query Neighborhood Hits	524	Target Neighborhood Hits	748	Shared Neighborhood Hits	81
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

IRAK1_HUMAN
NC score	0.069229 (rank : 713)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	524	Target Neighborhood Hits	820	Shared Neighborhood Hits	84
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

ACVL1_HUMAN
NC score	0.069213 (rank : 714)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	524	Target Neighborhood Hits	716	Shared Neighborhood Hits	76
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ALS_MOUSE
NC score	0.069025 (rank : 715)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	524	Target Neighborhood Hits	275	Shared Neighborhood Hits	42
SwissProt Accessions	P70389, Q9DBI7	Gene names	Igfals, Albs, Als
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

PKD1_HUMAN
NC score	0.069006 (rank : 716)	θ value	3.0926 (rank : 442)
Query Neighborhood Hits	524	Target Neighborhood Hits	387	Shared Neighborhood Hits	49
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

CPN2_HUMAN
NC score	0.069005 (rank : 717)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	43
SwissProt Accessions	P22792, Q86SU4, Q8N5V4	Gene names	CPN2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

NEK7_HUMAN
NC score	0.068968 (rank : 718)	θ value	θ > 10 (rank : 966)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

CD33_HUMAN
NC score	0.068952 (rank : 719)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	524	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	P20138, Q8TD24	Gene names	CD33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3) (gp67).

STK24_HUMAN
NC score	0.068899 (rank : 720)	θ value	θ > 10 (rank : 1162)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
NC score	0.068828 (rank : 721)	θ value	θ > 10 (rank : 1163)
Query Neighborhood Hits	524	Target Neighborhood Hits	856	Shared Neighborhood Hits	83
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

NEK7_MOUSE
NC score	0.068812 (rank : 722)	θ value	θ > 10 (rank : 967)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

LRC15_HUMAN
NC score	0.068773 (rank : 723)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

NEK11_HUMAN
NC score	0.068761 (rank : 724)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	524	Target Neighborhood Hits	1043	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

YSK4_HUMAN
NC score	0.068491 (rank : 725)	θ value	θ > 10 (rank : 1248)
Query Neighborhood Hits	524	Target Neighborhood Hits	921	Shared Neighborhood Hits	83
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

GP124_HUMAN
NC score	0.068467 (rank : 726)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	524	Target Neighborhood Hits	304	Shared Neighborhood Hits	50
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

TGFR2_MOUSE
NC score	0.068319 (rank : 727)	θ value	θ > 10 (rank : 1196)
Query Neighborhood Hits	524	Target Neighborhood Hits	748	Shared Neighborhood Hits	82
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

R4RL1_HUMAN
NC score	0.068282 (rank : 728)	θ value	θ > 10 (rank : 1089)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

CPN2_MOUSE
NC score	0.068015 (rank : 729)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	524	Target Neighborhood Hits	291	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

MST4_HUMAN
NC score	0.067853 (rank : 730)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	83
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MYLK2_HUMAN
NC score	0.067763 (rank : 731)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	524	Target Neighborhood Hits	920	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MST4_MOUSE
NC score	0.067740 (rank : 732)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	83
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

GP124_MOUSE
NC score	0.067671 (rank : 733)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	524	Target Neighborhood Hits	423	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

NEK6_HUMAN
NC score	0.067622 (rank : 734)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	524	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

IL18R_HUMAN
NC score	0.067504 (rank : 735)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	524	Target Neighborhood Hits	81	Shared Neighborhood Hits	42
SwissProt Accessions	Q13478	Gene names	IL18R1, IL1RRP
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp) (CDw218a antigen).

NEK6_MOUSE
NC score	0.067403 (rank : 736)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

GPV_HUMAN
NC score	0.067216 (rank : 737)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	524	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

LRTM1_MOUSE
NC score	0.066822 (rank : 738)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	524	Target Neighborhood Hits	264	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K377, Q3UVX1	Gene names	Lrrtm1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

NEK4_HUMAN
NC score	0.066068 (rank : 739)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	524	Target Neighborhood Hits	883	Shared Neighborhood Hits	84
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

RTN4R_MOUSE
NC score	0.065906 (rank : 740)	θ value	θ > 10 (rank : 1111)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

CD7_HUMAN
NC score	0.065843 (rank : 741)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	524	Target Neighborhood Hits	190	Shared Neighborhood Hits	63
SwissProt Accessions	P09564	Gene names	CD7
Domain Architecture
Description	T-cell antigen CD7 precursor (GP40) (T-cell leukemia antigen) (TP41) (Leu-9).

CD7_MOUSE
NC score	0.065773 (rank : 742)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	524	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	P50283	Gene names	Cd7
Domain Architecture
Description	T-cell antigen CD7 precursor.

MP2K5_MOUSE
NC score	0.065754 (rank : 743)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	84
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NEK4_MOUSE
NC score	0.065746 (rank : 744)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

TPBG_HUMAN
NC score	0.065710 (rank : 745)	θ value	θ > 10 (rank : 1219)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q13641	Gene names	TPBG, 5T4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (5T4 oncofetal antigen) (M6P1).

LRTM1_HUMAN
NC score	0.065620 (rank : 746)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	524	Target Neighborhood Hits	273	Shared Neighborhood Hits	40
SwissProt Accessions	Q86UE6, Q96DN1	Gene names	LRRTM1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

PTN23_MOUSE
NC score	0.065569 (rank : 747)	θ value	θ > 10 (rank : 1062)
Query Neighborhood Hits	524	Target Neighborhood Hits	726	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SLAF5_HUMAN
NC score	0.065542 (rank : 748)	θ value	θ > 10 (rank : 1123)
Query Neighborhood Hits	524	Target Neighborhood Hits	65	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UIB8, O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1, Q8WWI8, Q9UF04, Q9UIB6, Q9UIB7, Q9UIT7	Gene names	CD84, SLAMF5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen) (Cell surface antigen MAX.3) (Hly9-beta).

STK25_MOUSE
NC score	0.065482 (rank : 749)	θ value	θ > 10 (rank : 1165)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

LRTM2_MOUSE
NC score	0.065337 (rank : 750)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGA3, Q80U08	Gene names	Lrrtm2, Kiaa0416
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor.

E2AK2_HUMAN
NC score	0.065301 (rank : 751)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	524	Target Neighborhood Hits	856	Shared Neighborhood Hits	82
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

LRTM2_HUMAN
NC score	0.065233 (rank : 752)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	524	Target Neighborhood Hits	282	Shared Neighborhood Hits	42
SwissProt Accessions	O43300, Q7L770	Gene names	LRRTM2, KIAA0416, LRRN2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor (Leucine-rich repeat neuronal 2 protein).

STK25_HUMAN
NC score	0.065207 (rank : 753)	θ value	θ > 10 (rank : 1164)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

DAPK2_HUMAN
NC score	0.065109 (rank : 754)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ST17B_MOUSE
NC score	0.065044 (rank : 755)	θ value	θ > 10 (rank : 1157)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

DAPK3_HUMAN
NC score	0.065010 (rank : 756)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	524	Target Neighborhood Hits	945	Shared Neighborhood Hits	83
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

TRIM9_MOUSE
NC score	0.065005 (rank : 757)	θ value	3.0926 (rank : 446)
Query Neighborhood Hits	524	Target Neighborhood Hits	274	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

DAPK2_MOUSE
NC score	0.064996 (rank : 758)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	84
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

LRTM4_MOUSE
NC score	0.064972 (rank : 759)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	524	Target Neighborhood Hits	284	Shared Neighborhood Hits	44
SwissProt Accessions	Q80XG9, Q8C030, Q8JZS8	Gene names	Lrrtm4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

RIPK3_MOUSE
NC score	0.064857 (rank : 760)	θ value	θ > 10 (rank : 1104)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

R4RL1_MOUSE
NC score	0.064812 (rank : 761)	θ value	θ > 10 (rank : 1090)
Query Neighborhood Hits	524	Target Neighborhood Hits	235	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K0S5	Gene names	Rtn4rl1, Ngrl2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

DAPK3_MOUSE
NC score	0.064667 (rank : 762)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

LRTM4_HUMAN
NC score	0.064621 (rank : 763)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

GP1BA_HUMAN
NC score	0.064519 (rank : 764)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	524	Target Neighborhood Hits	407	Shared Neighborhood Hits	44
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

LRC52_HUMAN
NC score	0.064492 (rank : 765)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N7C0, Q5T9K5	Gene names	LRRC52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC52_MOUSE
NC score	0.064334 (rank : 766)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	524	Target Neighborhood Hits	240	Shared Neighborhood Hits	42
SwissProt Accessions	Q5M8M9	Gene names	Lrrc52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

MP2K5_HUMAN
NC score	0.064290 (rank : 767)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

STK4_MOUSE
NC score	0.064158 (rank : 768)	θ value	θ > 10 (rank : 1175)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

LRC17_MOUSE
NC score	0.064156 (rank : 769)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CXD9	Gene names	Lrrc17
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor.

TIMD1_HUMAN
NC score	0.063904 (rank : 770)	θ value	5.27518 (rank : 486)
Query Neighborhood Hits	524	Target Neighborhood Hits	155	Shared Neighborhood Hits	55
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

STK4_HUMAN
NC score	0.063878 (rank : 771)	θ value	θ > 10 (rank : 1174)
Query Neighborhood Hits	524	Target Neighborhood Hits	870	Shared Neighborhood Hits	83
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

LRC19_MOUSE
NC score	0.063870 (rank : 772)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	524	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BZT5, Q6P8J1	Gene names	Lrrc19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC55_HUMAN
NC score	0.063801 (rank : 773)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	524	Target Neighborhood Hits	257	Shared Neighborhood Hits	40
SwissProt Accessions	Q6ZSA7	Gene names	LRRC55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

IKKB_HUMAN
NC score	0.063792 (rank : 774)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	524	Target Neighborhood Hits	980	Shared Neighborhood Hits	83
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

TLR13_MOUSE
NC score	0.063746 (rank : 775)	θ value	θ > 10 (rank : 1198)
Query Neighborhood Hits	524	Target Neighborhood Hits	335	Shared Neighborhood Hits	55
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

LRC55_MOUSE
NC score	0.063737 (rank : 776)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	524	Target Neighborhood Hits	254	Shared Neighborhood Hits	42
SwissProt Accessions	Q3UY51	Gene names	Lrrc55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

STK3_MOUSE
NC score	0.063736 (rank : 777)	θ value	θ > 10 (rank : 1173)
Query Neighborhood Hits	524	Target Neighborhood Hits	869	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

LRTM3_HUMAN
NC score	0.063690 (rank : 778)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	524	Target Neighborhood Hits	276	Shared Neighborhood Hits	42
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

A2GL_HUMAN
NC score	0.063605 (rank : 779)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	524	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	P02750, Q8N4F5, Q96QZ4	Gene names	LRG1, LRG
Domain Architecture
Description	Leucine-rich alpha-2-glycoprotein precursor (LRG).

IKKB_MOUSE
NC score	0.063462 (rank : 780)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	524	Target Neighborhood Hits	984	Shared Neighborhood Hits	83
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

ULK3_MOUSE
NC score	0.063350 (rank : 781)	θ value	θ > 10 (rank : 1242)
Query Neighborhood Hits	524	Target Neighborhood Hits	872	Shared Neighborhood Hits	83
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_HUMAN
NC score	0.063293 (rank : 782)	θ value	θ > 10 (rank : 1241)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

TGFR1_MOUSE
NC score	0.063190 (rank : 783)	θ value	θ > 10 (rank : 1194)
Query Neighborhood Hits	524	Target Neighborhood Hits	753	Shared Neighborhood Hits	82
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

STK3_HUMAN
NC score	0.063169 (rank : 784)	θ value	θ > 10 (rank : 1172)
Query Neighborhood Hits	524	Target Neighborhood Hits	861	Shared Neighborhood Hits	83
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

BMR1B_MOUSE
NC score	0.063095 (rank : 785)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	524	Target Neighborhood Hits	758	Shared Neighborhood Hits	79
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

LRTM3_MOUSE
NC score	0.063068 (rank : 786)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	524	Target Neighborhood Hits	290	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

TGFR1_HUMAN
NC score	0.062969 (rank : 787)	θ value	θ > 10 (rank : 1193)
Query Neighborhood Hits	524	Target Neighborhood Hits	755	Shared Neighborhood Hits	82
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

STK33_HUMAN
NC score	0.062936 (rank : 788)	θ value	θ > 10 (rank : 1166)
Query Neighborhood Hits	524	Target Neighborhood Hits	879	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

PTN23_HUMAN
NC score	0.062864 (rank : 789)	θ value	θ > 10 (rank : 1061)
Query Neighborhood Hits	524	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

LRC32_HUMAN
NC score	0.062844 (rank : 790)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	524	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

ASPN_MOUSE
NC score	0.062759 (rank : 791)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	524	Target Neighborhood Hits	277	Shared Neighborhood Hits	42
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

ANKK1_MOUSE
NC score	0.062732 (rank : 792)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	524	Target Neighborhood Hits	1072	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

MAK_MOUSE
NC score	0.062721 (rank : 793)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	83
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

CD180_MOUSE
NC score	0.062677 (rank : 794)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	39
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

STK36_MOUSE
NC score	0.062547 (rank : 795)	θ value	θ > 10 (rank : 1169)
Query Neighborhood Hits	524	Target Neighborhood Hits	877	Shared Neighborhood Hits	83
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

E2AK3_MOUSE
NC score	0.062546 (rank : 796)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

TSK_MOUSE
NC score	0.062503 (rank : 797)	θ value	θ > 10 (rank : 1224)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

TPBG_MOUSE
NC score	0.062471 (rank : 798)	θ value	θ > 10 (rank : 1220)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0L0, Q6PE98, Q8BQA4	Gene names	Tpbg, 5t4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein).

MAK_HUMAN
NC score	0.062368 (rank : 799)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	82
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

LRRC3_MOUSE
NC score	0.062357 (rank : 800)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	524	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	P59034	Gene names	Lrrc3
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

E2AK2_MOUSE
NC score	0.062319 (rank : 801)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	524	Target Neighborhood Hits	864	Shared Neighborhood Hits	85
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

ASPN_HUMAN
NC score	0.062243 (rank : 802)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	524	Target Neighborhood Hits	274	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BXN1, Q96K79, Q96LD0, Q9NXP3	Gene names	ASPN, PLAP1
Domain Architecture
Description	Asporin precursor (Periodontal ligament-associated protein 1) (PLAP- 1).

PTN14_HUMAN
NC score	0.062200 (rank : 803)	θ value	θ > 10 (rank : 1051)
Query Neighborhood Hits	524	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

BMR1A_HUMAN
NC score	0.062080 (rank : 804)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	524	Target Neighborhood Hits	759	Shared Neighborhood Hits	82
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

CD33_MOUSE
NC score	0.062079 (rank : 805)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	524	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	Q63994, Q63997	Gene names	Cd33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3).

LGI4_HUMAN
NC score	0.062052 (rank : 806)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N135	Gene names	LGI4, LGIL3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

PTN21_MOUSE
NC score	0.062035 (rank : 807)	θ value	θ > 10 (rank : 1058)
Query Neighborhood Hits	524	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

BMR1A_MOUSE
NC score	0.061969 (rank : 808)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	524	Target Neighborhood Hits	758	Shared Neighborhood Hits	82
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

PTN14_MOUSE
NC score	0.061775 (rank : 809)	θ value	θ > 10 (rank : 1052)
Query Neighborhood Hits	524	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

OXSR1_HUMAN
NC score	0.061755 (rank : 810)	θ value	θ > 10 (rank : 988)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

KS6A3_HUMAN
NC score	0.061694 (rank : 811)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	524	Target Neighborhood Hits	859	Shared Neighborhood Hits	83
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

BMR1B_HUMAN
NC score	0.061668 (rank : 812)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	524	Target Neighborhood Hits	760	Shared Neighborhood Hits	79
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

KS6A3_MOUSE
NC score	0.061639 (rank : 813)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	83
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

TLR5_HUMAN
NC score	0.061587 (rank : 814)	θ value	θ > 10 (rank : 1203)
Query Neighborhood Hits	524	Target Neighborhood Hits	288	Shared Neighborhood Hits	48
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

LRC19_HUMAN
NC score	0.061565 (rank : 815)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	524	Target Neighborhood Hits	217	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H756	Gene names	LRRC19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

STK36_HUMAN
NC score	0.061539 (rank : 816)	θ value	θ > 10 (rank : 1168)
Query Neighborhood Hits	524	Target Neighborhood Hits	896	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

CDK4_MOUSE
NC score	0.061539 (rank : 817)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	83
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK6_MOUSE
NC score	0.061498 (rank : 818)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	83
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

OXSR1_MOUSE
NC score	0.061425 (rank : 819)	θ value	θ > 10 (rank : 989)
Query Neighborhood Hits	524	Target Neighborhood Hits	865	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ACVR1_MOUSE
NC score	0.061371 (rank : 820)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	524	Target Neighborhood Hits	768	Shared Neighborhood Hits	80
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

STK39_MOUSE
NC score	0.061333 (rank : 821)	θ value	θ > 10 (rank : 1171)
Query Neighborhood Hits	524	Target Neighborhood Hits	915	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

ICK_HUMAN
NC score	0.061313 (rank : 822)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

CDK6_HUMAN
NC score	0.061250 (rank : 823)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	83
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

LR37B_HUMAN
NC score	0.061237 (rank : 824)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	524	Target Neighborhood Hits	392	Shared Neighborhood Hits	43
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

LGR5_HUMAN
NC score	0.061207 (rank : 825)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	524	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

PTN21_HUMAN
NC score	0.061204 (rank : 826)	θ value	θ > 10 (rank : 1057)
Query Neighborhood Hits	524	Target Neighborhood Hits	143	Shared Neighborhood Hits	17
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

STK39_HUMAN
NC score	0.061119 (rank : 827)	θ value	θ > 10 (rank : 1170)
Query Neighborhood Hits	524	Target Neighborhood Hits	882	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

NEK3_HUMAN
NC score	0.061075 (rank : 828)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	524	Target Neighborhood Hits	865	Shared Neighborhood Hits	83
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

TLR3_MOUSE
NC score	0.061028 (rank : 829)	θ value	θ > 10 (rank : 1200)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	44
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

ICK_MOUSE
NC score	0.060987 (rank : 830)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

KS6A1_HUMAN
NC score	0.060946 (rank : 831)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	83
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

E2AK3_HUMAN
NC score	0.060940 (rank : 832)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	524	Target Neighborhood Hits	859	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

CDK4_HUMAN
NC score	0.060920 (rank : 833)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	83
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

KS6A2_HUMAN
NC score	0.060833 (rank : 834)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PLK4_MOUSE
NC score	0.060825 (rank : 835)	θ value	θ > 10 (rank : 1034)
Query Neighborhood Hits	524	Target Neighborhood Hits	879	Shared Neighborhood Hits	84
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

ST17B_HUMAN
NC score	0.060784 (rank : 836)	θ value	θ > 10 (rank : 1156)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	79
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MOG_MOUSE
NC score	0.060735 (rank : 837)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	67
SwissProt Accessions	Q61885, P70364, Q62003	Gene names	Mog
Domain Architecture
Description	Myelin-oligodendrocyte glycoprotein precursor.

PKN1_MOUSE
NC score	0.060718 (rank : 838)	θ value	θ > 10 (rank : 1022)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	83
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

ST17A_HUMAN
NC score	0.060688 (rank : 839)	θ value	θ > 10 (rank : 1155)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

PGS1_MOUSE
NC score	0.060679 (rank : 840)	θ value	θ > 10 (rank : 1015)
Query Neighborhood Hits	524	Target Neighborhood Hits	265	Shared Neighborhood Hits	40
SwissProt Accessions	P28653, Q61355	Gene names	Bgn
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

LGR5_MOUSE
NC score	0.060671 (rank : 841)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	524	Target Neighborhood Hits	484	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1P4	Gene names	Lgr5, Fex, Gpr49
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX).

PGS1_HUMAN
NC score	0.060665 (rank : 842)	θ value	θ > 10 (rank : 1014)
Query Neighborhood Hits	524	Target Neighborhood Hits	261	Shared Neighborhood Hits	40
SwissProt Accessions	P21810, P13247	Gene names	BGN
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

RIPK4_HUMAN
NC score	0.060570 (rank : 843)	θ value	θ > 10 (rank : 1105)
Query Neighborhood Hits	524	Target Neighborhood Hits	1094	Shared Neighborhood Hits	82
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ULK2_HUMAN
NC score	0.060525 (rank : 844)	θ value	θ > 10 (rank : 1239)
Query Neighborhood Hits	524	Target Neighborhood Hits	979	Shared Neighborhood Hits	89
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

PKN1_HUMAN
NC score	0.060519 (rank : 845)	θ value	θ > 10 (rank : 1021)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

LRC17_HUMAN
NC score	0.060485 (rank : 846)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	524	Target Neighborhood Hits	267	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

PLK4_HUMAN
NC score	0.060477 (rank : 847)	θ value	θ > 10 (rank : 1033)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	85
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

SCN2B_MOUSE
NC score	0.060467 (rank : 848)	θ value	6.88961 (rank : 501)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	47
SwissProt Accessions	Q56A07	Gene names	Scn2b
Domain Architecture	No domain graphic available
Description	Sodium channel beta-2 subunit precursor.

NEK3_MOUSE
NC score	0.060454 (rank : 849)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

ACVR1_HUMAN
NC score	0.060402 (rank : 850)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	524	Target Neighborhood Hits	760	Shared Neighborhood Hits	80
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

GPIX_HUMAN
NC score	0.060365 (rank : 851)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	524	Target Neighborhood Hits	162	Shared Neighborhood Hits	39
SwissProt Accessions	P14770, Q14445, Q92525	Gene names	GP9
Domain Architecture
Description	Platelet glycoprotein IX precursor (GPIX) (CD42a antigen).

TIMD1_MOUSE
NC score	0.060362 (rank : 852)	θ value	1.81305 (rank : 425)
Query Neighborhood Hits	524	Target Neighborhood Hits	97	Shared Neighborhood Hits	52
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

NEK9_HUMAN
NC score	0.060343 (rank : 853)	θ value	θ > 10 (rank : 970)
Query Neighborhood Hits	524	Target Neighborhood Hits	900	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

LRC33_HUMAN
NC score	0.060288 (rank : 854)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

ULK2_MOUSE
NC score	0.060258 (rank : 855)	θ value	θ > 10 (rank : 1240)
Query Neighborhood Hits	524	Target Neighborhood Hits	943	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

KS6A2_MOUSE
NC score	0.060258 (rank : 856)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

NEK1_HUMAN
NC score	0.060241 (rank : 857)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	524	Target Neighborhood Hits	1129	Shared Neighborhood Hits	85
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

MUC_MOUSE
NC score	0.060220 (rank : 858)	θ value	1.38821 (rank : 417)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	48
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

PGS2_MOUSE
NC score	0.060206 (rank : 859)	θ value	θ > 10 (rank : 1017)
Query Neighborhood Hits	524	Target Neighborhood Hits	285	Shared Neighborhood Hits	41
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

NEK1_MOUSE
NC score	0.060195 (rank : 860)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	524	Target Neighborhood Hits	1311	Shared Neighborhood Hits	86
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

AGRIN_HUMAN
NC score	0.060191 (rank : 861)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	524	Target Neighborhood Hits	582	Shared Neighborhood Hits	42
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ANKK1_HUMAN
NC score	0.060139 (rank : 862)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	524	Target Neighborhood Hits	1075	Shared Neighborhood Hits	82
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

PAK6_HUMAN
NC score	0.060083 (rank : 863)	θ value	θ > 10 (rank : 998)
Query Neighborhood Hits	524	Target Neighborhood Hits	915	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

NUAK2_HUMAN
NC score	0.059938 (rank : 864)	θ value	θ > 10 (rank : 980)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

LGR4_HUMAN
NC score	0.059919 (rank : 865)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	524	Target Neighborhood Hits	481	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

ULK1_HUMAN
NC score	0.059899 (rank : 866)	θ value	θ > 10 (rank : 1237)
Query Neighborhood Hits	524	Target Neighborhood Hits	1121	Shared Neighborhood Hits	87
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

AURKC_HUMAN
NC score	0.059698 (rank : 867)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

PTN3_HUMAN
NC score	0.059674 (rank : 868)	θ value	θ > 10 (rank : 1065)
Query Neighborhood Hits	524	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

TLR3_HUMAN
NC score	0.059627 (rank : 869)	θ value	θ > 10 (rank : 1199)
Query Neighborhood Hits	524	Target Neighborhood Hits	323	Shared Neighborhood Hits	46
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

CD83_HUMAN
NC score	0.059600 (rank : 870)	θ value	0.365318 (rank : 385)
Query Neighborhood Hits	524	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q01151	Gene names	CD83
Domain Architecture
Description	CD83 antigen precursor (Cell surface protein HB15) (B-cell activation protein).

MUCM_MOUSE
NC score	0.059585 (rank : 871)	θ value	1.38821 (rank : 416)
Query Neighborhood Hits	524	Target Neighborhood Hits	242	Shared Neighborhood Hits	48
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

ULK1_MOUSE
NC score	0.059572 (rank : 872)	θ value	θ > 10 (rank : 1238)
Query Neighborhood Hits	524	Target Neighborhood Hits	1214	Shared Neighborhood Hits	91
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

BMPR2_HUMAN
NC score	0.059425 (rank : 873)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	524	Target Neighborhood Hits	736	Shared Neighborhood Hits	78
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

CD2L7_HUMAN
NC score	0.059418 (rank : 874)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	524	Target Neighborhood Hits	1275	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

ACV1C_HUMAN
NC score	0.059411 (rank : 875)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	524	Target Neighborhood Hits	709	Shared Neighborhood Hits	80
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

CD180_HUMAN
NC score	0.059402 (rank : 876)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	39
SwissProt Accessions	Q99467	Gene names	CD180, LY64, RP105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 64) (Radioprotective 105 kDa protein).

KS6A6_HUMAN
NC score	0.059235 (rank : 877)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

NEK9_MOUSE
NC score	0.059156 (rank : 878)	θ value	θ > 10 (rank : 971)
Query Neighborhood Hits	524	Target Neighborhood Hits	890	Shared Neighborhood Hits	84
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

LGR6_HUMAN
NC score	0.059127 (rank : 879)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	524	Target Neighborhood Hits	344	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

LGI2_HUMAN
NC score	0.059013 (rank : 880)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	524	Target Neighborhood Hits	232	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N0V4, Q8NDW6, Q96PX2, Q9NVK4	Gene names	LGI2, KIAA1916, LGIL2
Domain Architecture
Description	Leucine-rich repeat LGI family member 2 precursor (Leucine-rich glioma-inactivated protein 2) (LGI1-like protein 2).

NEK2_HUMAN
NC score	0.058865 (rank : 881)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	524	Target Neighborhood Hits	908	Shared Neighborhood Hits	83
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

TLR5_MOUSE
NC score	0.058842 (rank : 882)	θ value	θ > 10 (rank : 1204)
Query Neighborhood Hits	524	Target Neighborhood Hits	287	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

M3K15_HUMAN
NC score	0.058836 (rank : 883)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	524	Target Neighborhood Hits	914	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

PLK1_HUMAN
NC score	0.058831 (rank : 884)	θ value	θ > 10 (rank : 1027)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

AURKB_HUMAN
NC score	0.058799 (rank : 885)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

SIGIR_HUMAN
NC score	0.058780 (rank : 886)	θ value	5.27518 (rank : 484)
Query Neighborhood Hits	524	Target Neighborhood Hits	53	Shared Neighborhood Hits	27
SwissProt Accessions	Q6IA17, Q3KQY2, Q6UXI3, Q9H733	Gene names	SIGIRR
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

MAMC2_HUMAN
NC score	0.058770 (rank : 887)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	524	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

LGI1_MOUSE
NC score	0.058655 (rank : 888)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JIA1	Gene names	Lgi1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor.

STK6_HUMAN
NC score	0.058639 (rank : 889)	θ value	θ > 10 (rank : 1176)
Query Neighborhood Hits	524	Target Neighborhood Hits	916	Shared Neighborhood Hits	85
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

GP1BB_MOUSE
NC score	0.058607 (rank : 890)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	524	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	P56400	Gene names	Gp1bb
Domain Architecture
Description	Platelet glycoprotein Ib beta chain precursor (GP-Ib beta) (GPIbB) (GPIb-beta) (CD42c antigen).

MYP0_HUMAN
NC score	0.058587 (rank : 891)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	524	Target Neighborhood Hits	58	Shared Neighborhood Hits	42
SwissProt Accessions	P25189, Q16072, Q92677, Q9BR67	Gene names	MPZ
Domain Architecture
Description	Myelin P0 protein precursor (Myelin protein zero) (Myelin peripheral protein) (MPP).

RXFP2_MOUSE
NC score	0.058561 (rank : 892)	θ value	θ > 10 (rank : 1114)
Query Neighborhood Hits	524	Target Neighborhood Hits	760	Shared Neighborhood Hits	45
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

AURKC_MOUSE
NC score	0.058501 (rank : 893)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	524	Target Neighborhood Hits	844	Shared Neighborhood Hits	83
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

LGI1_HUMAN
NC score	0.058491 (rank : 894)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	524	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	O95970, Q5W001, Q5W002, Q8NI23, Q96LF5	Gene names	LGI1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor (Epitempin-1).

NUAK2_MOUSE
NC score	0.058423 (rank : 895)	θ value	θ > 10 (rank : 981)
Query Neighborhood Hits	524	Target Neighborhood Hits	878	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

LGI4_MOUSE
NC score	0.058397 (rank : 896)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	524	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K1S1, Q8K4Y8	Gene names	Lgi4, Lgil3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

MAMC2_MOUSE
NC score	0.058371 (rank : 897)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	524	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

PAK7_HUMAN
NC score	0.058307 (rank : 898)	θ value	θ > 10 (rank : 999)
Query Neighborhood Hits	524	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PGS2_HUMAN
NC score	0.058278 (rank : 899)	θ value	θ > 10 (rank : 1016)
Query Neighborhood Hits	524	Target Neighborhood Hits	271	Shared Neighborhood Hits	40
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

LGI3_HUMAN
NC score	0.058265 (rank : 900)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	524	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N145, Q86TL4, Q8N296	Gene names	LGI3, LGIL4
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (LGI1-like protein 4).

PLK2_MOUSE
NC score	0.058119 (rank : 901)	θ value	θ > 10 (rank : 1030)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

M3K1_MOUSE
NC score	0.058108 (rank : 902)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	524	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

AAPK1_HUMAN
NC score	0.058101 (rank : 903)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KS6A1_MOUSE
NC score	0.058098 (rank : 904)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PLK2_HUMAN
NC score	0.058028 (rank : 905)	θ value	θ > 10 (rank : 1029)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

M3K5_MOUSE
NC score	0.057903 (rank : 906)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

PAK7_MOUSE
NC score	0.057880 (rank : 907)	θ value	θ > 10 (rank : 1000)
Query Neighborhood Hits	524	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PP1R7_HUMAN
NC score	0.057876 (rank : 908)	θ value	θ > 10 (rank : 1035)
Query Neighborhood Hits	524	Target Neighborhood Hits	265	Shared Neighborhood Hits	33
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

PKN2_HUMAN
NC score	0.057846 (rank : 909)	θ value	θ > 10 (rank : 1023)
Query Neighborhood Hits	524	Target Neighborhood Hits	892	Shared Neighborhood Hits	83
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

STK16_MOUSE
NC score	0.057834 (rank : 910)	θ value	θ > 10 (rank : 1161)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	81
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

AAPK1_MOUSE
NC score	0.057756 (rank : 911)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

CD2L5_HUMAN
NC score	0.057738 (rank : 912)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	524	Target Neighborhood Hits	987	Shared Neighborhood Hits	87
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

M3K5_HUMAN
NC score	0.057732 (rank : 913)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	524	Target Neighborhood Hits	868	Shared Neighborhood Hits	83
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

SN1L2_HUMAN
NC score	0.057693 (rank : 914)	θ value	θ > 10 (rank : 1147)
Query Neighborhood Hits	524	Target Neighborhood Hits	964	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

CDK3_HUMAN
NC score	0.057686 (rank : 915)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	82
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

BMPR2_MOUSE
NC score	0.057652 (rank : 916)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	524	Target Neighborhood Hits	738	Shared Neighborhood Hits	78
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

NEK8_MOUSE
NC score	0.057645 (rank : 917)	θ value	θ > 10 (rank : 969)
Query Neighborhood Hits	524	Target Neighborhood Hits	872	Shared Neighborhood Hits	84
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

STK16_HUMAN
NC score	0.057644 (rank : 918)	θ value	θ > 10 (rank : 1160)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	81
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

CD2L5_MOUSE
NC score	0.057629 (rank : 919)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	524	Target Neighborhood Hits	1011	Shared Neighborhood Hits	86
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

NEK8_HUMAN
NC score	0.057587 (rank : 920)	θ value	θ > 10 (rank : 968)
Query Neighborhood Hits	524	Target Neighborhood Hits	872	Shared Neighborhood Hits	83
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

PKN2_MOUSE
NC score	0.057583 (rank : 921)	θ value	θ > 10 (rank : 1024)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PTN4_HUMAN
NC score	0.057524 (rank : 922)	θ value	θ > 10 (rank : 1066)
Query Neighborhood Hits	524	Target Neighborhood Hits	303	Shared Neighborhood Hits	18
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PKN3_MOUSE
NC score	0.057522 (rank : 923)	θ value	θ > 10 (rank : 1026)
Query Neighborhood Hits	524	Target Neighborhood Hits	1009	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

NUAK1_HUMAN
NC score	0.057520 (rank : 924)	θ value	θ > 10 (rank : 978)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

RXFP2_HUMAN
NC score	0.057509 (rank : 925)	θ value	θ > 10 (rank : 1113)
Query Neighborhood Hits	524	Target Neighborhood Hits	736	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

LRC33_MOUSE
NC score	0.057472 (rank : 926)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	524	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

STK11_HUMAN
NC score	0.057410 (rank : 927)	θ value	θ > 10 (rank : 1159)
Query Neighborhood Hits	524	Target Neighborhood Hits	831	Shared Neighborhood Hits	82
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK6_MOUSE
NC score	0.057407 (rank : 928)	θ value	θ > 10 (rank : 1177)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

SN1L2_MOUSE
NC score	0.057401 (rank : 929)	θ value	θ > 10 (rank : 1148)
Query Neighborhood Hits	524	Target Neighborhood Hits	944	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

NRK_HUMAN
NC score	0.057304 (rank : 930)	θ value	θ > 10 (rank : 976)
Query Neighborhood Hits	524	Target Neighborhood Hits	931	Shared Neighborhood Hits	82
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NUAK1_MOUSE
NC score	0.057223 (rank : 931)	θ value	θ > 10 (rank : 979)
Query Neighborhood Hits	524	Target Neighborhood Hits	881	Shared Neighborhood Hits	84
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

PLK3_MOUSE
NC score	0.057198 (rank : 932)	θ value	θ > 10 (rank : 1032)
Query Neighborhood Hits	524	Target Neighborhood Hits	863	Shared Neighborhood Hits	83
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

KKCC2_HUMAN
NC score	0.057194 (rank : 933)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

AURKB_MOUSE
NC score	0.057151 (rank : 934)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

CDKL2_HUMAN
NC score	0.057138 (rank : 935)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	82
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

KKCC2_MOUSE
NC score	0.057137 (rank : 936)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	524	Target Neighborhood Hits	855	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPSH2_HUMAN
NC score	0.057134 (rank : 937)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

PKN3_HUMAN
NC score	0.056919 (rank : 938)	θ value	θ > 10 (rank : 1025)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

LGI3_MOUSE
NC score	0.056917 (rank : 939)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	524	Target Neighborhood Hits	229	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

SLK_HUMAN
NC score	0.056865 (rank : 940)	θ value	θ > 10 (rank : 1143)
Query Neighborhood Hits	524	Target Neighborhood Hits	1775	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

E2AK1_MOUSE
NC score	0.056738 (rank : 941)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_HUMAN
NC score	0.056653 (rank : 942)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

PINK1_MOUSE
NC score	0.056649 (rank : 943)	θ value	θ > 10 (rank : 1020)
Query Neighborhood Hits	524	Target Neighborhood Hits	726	Shared Neighborhood Hits	76
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

KPCD_HUMAN
NC score	0.056630 (rank : 944)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	524	Target Neighborhood Hits	900	Shared Neighborhood Hits	83
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

SN1L1_MOUSE
NC score	0.056606 (rank : 945)	θ value	θ > 10 (rank : 1146)
Query Neighborhood Hits	524	Target Neighborhood Hits	895	Shared Neighborhood Hits	84
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

PLK1_MOUSE
NC score	0.056584 (rank : 946)	θ value	θ > 10 (rank : 1028)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

MP2K4_MOUSE
NC score	0.056581 (rank : 947)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MARK3_HUMAN
NC score	0.056534 (rank : 948)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	89
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MP2K4_HUMAN
NC score	0.056493 (rank : 949)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

LR37A_HUMAN
NC score	0.056475 (rank : 950)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	524	Target Neighborhood Hits	720	Shared Neighborhood Hits	55
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

PAK1_HUMAN
NC score	0.056474 (rank : 951)	θ value	θ > 10 (rank : 990)
Query Neighborhood Hits	524	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

SLK_MOUSE
NC score	0.056462 (rank : 952)	θ value	θ > 10 (rank : 1144)
Query Neighborhood Hits	524	Target Neighborhood Hits	1798	Shared Neighborhood Hits	87
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

PLK3_HUMAN
NC score	0.056257 (rank : 953)	θ value	θ > 10 (rank : 1031)
Query Neighborhood Hits	524	Target Neighborhood Hits	865	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

LRRC3_HUMAN
NC score	0.056236 (rank : 954)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	524	Target Neighborhood Hits	232	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BY71	Gene names	LRRC3, C21orf102
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

CDC2_HUMAN
NC score	0.056234 (rank : 955)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	82
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

PAK1_MOUSE
NC score	0.056199 (rank : 956)	θ value	θ > 10 (rank : 991)
Query Neighborhood Hits	524	Target Neighborhood Hits	878	Shared Neighborhood Hits	84
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

TLR9_HUMAN
NC score	0.056197 (rank : 957)	θ value	θ > 10 (rank : 1209)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR96, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3	Gene names	TLR9
Domain Architecture
Description	Toll-like receptor 9 precursor (CD289 antigen).

PAK2_MOUSE
NC score	0.056142 (rank : 958)	θ value	θ > 10 (rank : 993)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

AAPK2_HUMAN
NC score	0.056120 (rank : 959)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

PAK2_HUMAN
NC score	0.056078 (rank : 960)	θ value	θ > 10 (rank : 992)
Query Neighborhood Hits	524	Target Neighborhood Hits	862	Shared Neighborhood Hits	83
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

CDK2_HUMAN
NC score	0.056078 (rank : 961)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

KPCD_MOUSE
NC score	0.056070 (rank : 962)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	83
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MARK2_HUMAN
NC score	0.056067 (rank : 963)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	524	Target Neighborhood Hits	1056	Shared Neighborhood Hits	92
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

CDK2_MOUSE
NC score	0.056046 (rank : 964)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	83
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK7_MOUSE
NC score	0.055993 (rank : 965)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	83
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK5_MOUSE
NC score	0.055983 (rank : 966)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	80
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

FMOD_HUMAN
NC score	0.055897 (rank : 967)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	39
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

CDK5_HUMAN
NC score	0.055896 (rank : 968)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	80
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

PAK4_MOUSE
NC score	0.055888 (rank : 969)	θ value	θ > 10 (rank : 997)
Query Neighborhood Hits	524	Target Neighborhood Hits	1098	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MP2K6_HUMAN
NC score	0.055834 (rank : 970)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

SN1L1_HUMAN
NC score	0.055814 (rank : 971)	θ value	θ > 10 (rank : 1145)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	87
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

AVR2A_MOUSE
NC score	0.055766 (rank : 972)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	524	Target Neighborhood Hits	767	Shared Neighborhood Hits	79
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.055764 (rank : 973)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	524	Target Neighborhood Hits	767	Shared Neighborhood Hits	79
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

CDC2_MOUSE
NC score	0.055749 (rank : 974)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	82
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

MINK1_HUMAN
NC score	0.055744 (rank : 975)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	524	Target Neighborhood Hits	1477	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MARK1_HUMAN
NC score	0.055725 (rank : 976)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	524	Target Neighborhood Hits	887	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

UHMK1_MOUSE
NC score	0.055717 (rank : 977)	θ value	θ > 10 (rank : 1236)
Query Neighborhood Hits	524	Target Neighborhood Hits	809	Shared Neighborhood Hits	75
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

AMHR2_HUMAN
NC score	0.055706 (rank : 978)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	78
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ACV1C_MOUSE
NC score	0.055623 (rank : 979)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	524	Target Neighborhood Hits	715	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

PAK4_HUMAN
NC score	0.055606 (rank : 980)	θ value	θ > 10 (rank : 996)
Query Neighborhood Hits	524	Target Neighborhood Hits	924	Shared Neighborhood Hits	86
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MINK1_MOUSE
NC score	0.055578 (rank : 981)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	524	Target Neighborhood Hits	1451	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

CDK7_HUMAN
NC score	0.055542 (rank : 982)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

MK07_MOUSE
NC score	0.055493 (rank : 983)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	524	Target Neighborhood Hits	1054	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

TLR4_MOUSE
NC score	0.055480 (rank : 984)	θ value	θ > 10 (rank : 1202)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QUK6, Q9D691, Q9QZF5, Q9Z203	Gene names	Tlr4, Lps
Domain Architecture
Description	Toll-like receptor 4 precursor (CD284 antigen).

NEK2_MOUSE
NC score	0.055461 (rank : 985)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	524	Target Neighborhood Hits	876	Shared Neighborhood Hits	83
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

SLIK6_HUMAN
NC score	0.055406 (rank : 986)	θ value	θ > 10 (rank : 1135)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H5Y7, Q495Q0, Q6AW93, Q9HAA8, Q9NT60	Gene names	SLITRK6
Domain Architecture	No domain graphic available
Description	SLIT and NTRK-like protein 6 precursor.

KCC1A_HUMAN
NC score	0.055388 (rank : 987)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
NC score	0.055338 (rank : 988)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	524	Target Neighborhood Hits	845	Shared Neighborhood Hits	83
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

SCN4B_HUMAN
NC score	0.055327 (rank : 989)	θ value	θ > 10 (rank : 1117)
Query Neighborhood Hits	524	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWT1, Q6PIG5	Gene names	SCN4B
Domain Architecture	No domain graphic available
Description	Sodium channel beta-4 subunit precursor.

TAOK2_HUMAN
NC score	0.055292 (rank : 990)	θ value	θ > 10 (rank : 1181)
Query Neighborhood Hits	524	Target Neighborhood Hits	1172	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

MARK1_MOUSE
NC score	0.055243 (rank : 991)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

UHMK1_HUMAN
NC score	0.055236 (rank : 992)	θ value	θ > 10 (rank : 1235)
Query Neighborhood Hits	524	Target Neighborhood Hits	808	Shared Neighborhood Hits	74
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

CDKL4_MOUSE
NC score	0.055215 (rank : 993)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	81
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

MP2K3_HUMAN
NC score	0.055132 (rank : 994)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	83
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MARK3_MOUSE
NC score	0.055132 (rank : 995)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	524	Target Neighborhood Hits	919	Shared Neighborhood Hits	87
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MP2K6_MOUSE
NC score	0.055124 (rank : 996)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

ECM2_HUMAN
NC score	0.055094 (rank : 997)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	524	Target Neighborhood Hits	402	Shared Neighborhood Hits	37
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

DAPK1_HUMAN
NC score	0.055092 (rank : 998)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	524	Target Neighborhood Hits	1130	Shared Neighborhood Hits	89
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

M4K4_MOUSE
NC score	0.055086 (rank : 999)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	524	Target Neighborhood Hits	1560	Shared Neighborhood Hits	86
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MYP0_MOUSE
NC score	0.055047 (rank : 1000)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	524	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	P27573	Gene names	Mpz, P0
Domain Architecture
Description	Myelin P0 protein precursor (Myelin protein zero) (Myelin peripheral protein) (MPP).

CDKL2_MOUSE
NC score	0.055019 (rank : 1001)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	524	Target Neighborhood Hits	854	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

ACV1B_MOUSE
NC score	0.054990 (rank : 1002)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	524	Target Neighborhood Hits	753	Shared Neighborhood Hits	81
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

KPCT_HUMAN
NC score	0.054988 (rank : 1003)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	524	Target Neighborhood Hits	897	Shared Neighborhood Hits	83
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MK04_HUMAN
NC score	0.054987 (rank : 1004)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	80
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

TLR4_HUMAN
NC score	0.054977 (rank : 1005)	θ value	θ > 10 (rank : 1201)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	50
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).

M4K1_MOUSE
NC score	0.054903 (rank : 1006)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

SLIK6_MOUSE
NC score	0.054883 (rank : 1007)	θ value	θ > 10 (rank : 1136)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C110, Q8BLL0	Gene names	Slitrk6, Sltk6
Domain Architecture
Description	SLIT and NTRK-like protein 6 precursor.

MK07_HUMAN
NC score	0.054866 (rank : 1008)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	524	Target Neighborhood Hits	1087	Shared Neighborhood Hits	88
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MP2K7_HUMAN
NC score	0.054853 (rank : 1009)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	524	Target Neighborhood Hits	833	Shared Neighborhood Hits	82
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

M3K6_HUMAN
NC score	0.054850 (rank : 1010)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	524	Target Neighborhood Hits	889	Shared Neighborhood Hits	86
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

NLK_MOUSE
NC score	0.054841 (rank : 1011)	θ value	θ > 10 (rank : 975)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	85
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NLK_HUMAN
NC score	0.054839 (rank : 1012)	θ value	θ > 10 (rank : 974)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NIM1_HUMAN
NC score	0.054812 (rank : 1013)	θ value	θ > 10 (rank : 972)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TLR7_HUMAN
NC score	0.054745 (rank : 1014)	θ value	θ > 10 (rank : 1205)
Query Neighborhood Hits	524	Target Neighborhood Hits	312	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYK1, Q9NR98	Gene names	TLR7
Domain Architecture
Description	Toll-like receptor 7 precursor.

M4K1_HUMAN
NC score	0.054743 (rank : 1015)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	83
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

TLR8_MOUSE
NC score	0.054742 (rank : 1016)	θ value	θ > 10 (rank : 1208)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	49
SwissProt Accessions	P58682, Q91XI7	Gene names	Tlr8
Domain Architecture
Description	Toll-like receptor 8 precursor.

M3K3_HUMAN
NC score	0.054715 (rank : 1017)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	524	Target Neighborhood Hits	885	Shared Neighborhood Hits	85
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NRK_MOUSE
NC score	0.054683 (rank : 1018)	θ value	θ > 10 (rank : 977)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

PP1R7_MOUSE
NC score	0.054673 (rank : 1019)	θ value	θ > 10 (rank : 1036)
Query Neighborhood Hits	524	Target Neighborhood Hits	256	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UM45, Q9CV31, Q9Z105	Gene names	Ppp1r7, Sds22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

PAK3_MOUSE
NC score	0.054666 (rank : 1020)	θ value	θ > 10 (rank : 995)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PTN13_MOUSE
NC score	0.054659 (rank : 1021)	θ value	θ > 10 (rank : 1050)
Query Neighborhood Hits	524	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

TLR8_HUMAN
NC score	0.054652 (rank : 1022)	θ value	θ > 10 (rank : 1207)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR97, Q6UXL6, Q9NYG9	Gene names	TLR8
Domain Architecture
Description	Toll-like receptor 8 precursor.

GRK4_MOUSE
NC score	0.054642 (rank : 1023)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	524	Target Neighborhood Hits	808	Shared Neighborhood Hits	83
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

ACV1B_HUMAN
NC score	0.054625 (rank : 1024)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	524	Target Neighborhood Hits	753	Shared Neighborhood Hits	81
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

MARK2_MOUSE
NC score	0.054622 (rank : 1025)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	524	Target Neighborhood Hits	1018	Shared Neighborhood Hits	89
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

PDPK1_MOUSE
NC score	0.054608 (rank : 1026)	θ value	θ > 10 (rank : 1011)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

KPCT_MOUSE
NC score	0.054592 (rank : 1027)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	524	Target Neighborhood Hits	895	Shared Neighborhood Hits	83
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

PCTK1_MOUSE
NC score	0.054590 (rank : 1028)	θ value	θ > 10 (rank : 1002)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	84
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

DAPK1_MOUSE
NC score	0.054575 (rank : 1029)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	524	Target Neighborhood Hits	1138	Shared Neighborhood Hits	89
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

PAK3_HUMAN
NC score	0.054558 (rank : 1030)	θ value	θ > 10 (rank : 994)
Query Neighborhood Hits	524	Target Neighborhood Hits	887	Shared Neighborhood Hits	84
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

M3K3_MOUSE
NC score	0.054550 (rank : 1031)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	524	Target Neighborhood Hits	876	Shared Neighborhood Hits	84
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

PCTK2_MOUSE
NC score	0.054495 (rank : 1032)	θ value	θ > 10 (rank : 1004)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_HUMAN
NC score	0.054446 (rank : 1033)	θ value	θ > 10 (rank : 1003)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	81
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PDPK1_HUMAN
NC score	0.054438 (rank : 1034)	θ value	θ > 10 (rank : 1010)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

MP2K3_MOUSE
NC score	0.054421 (rank : 1035)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

OMGP_HUMAN
NC score	0.054417 (rank : 1036)	θ value	θ > 10 (rank : 985)
Query Neighborhood Hits	524	Target Neighborhood Hits	268	Shared Neighborhood Hits	38
SwissProt Accessions	P23515	Gene names	OMG, OMGP
Domain Architecture
Description	Oligodendrocyte-myelin glycoprotein precursor.

OMGP_MOUSE
NC score	0.054396 (rank : 1037)	θ value	θ > 10 (rank : 986)
Query Neighborhood Hits	524	Target Neighborhood Hits	280	Shared Neighborhood Hits	38
SwissProt Accessions	Q63912	Gene names	Omg, Omgp
Domain Architecture
Description	Oligodendrocyte-myelin glycoprotein precursor.

RXFP1_HUMAN
NC score	0.054324 (rank : 1038)	θ value	θ > 10 (rank : 1112)
Query Neighborhood Hits	524	Target Neighborhood Hits	816	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HBX9	Gene names	RXFP1, LGR7
Domain Architecture
Description	Relaxin receptor 1 (Relaxin family peptide receptor 1) (Leucine-rich repeat-containing G-protein coupled receptor 7).

LUM_HUMAN
NC score	0.054301 (rank : 1039)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	524	Target Neighborhood Hits	284	Shared Neighborhood Hits	37
SwissProt Accessions	P51884, Q96QM7	Gene names	LUM, LDC
Domain Architecture
Description	Lumican precursor (Keratan sulfate proteoglycan lumican) (KSPG lumican).

CDKL3_HUMAN
NC score	0.054267 (rank : 1040)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	524	Target Neighborhood Hits	853	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

M3K8_HUMAN
NC score	0.054262 (rank : 1041)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	524	Target Neighborhood Hits	807	Shared Neighborhood Hits	76
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

TNIK_HUMAN
NC score	0.054254 (rank : 1042)	θ value	θ > 10 (rank : 1214)
Query Neighborhood Hits	524	Target Neighborhood Hits	1570	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

PCTK1_HUMAN
NC score	0.054225 (rank : 1043)	θ value	θ > 10 (rank : 1001)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	82
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

FMOD_MOUSE
NC score	0.054165 (rank : 1044)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	524	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

MELK_MOUSE
NC score	0.054109 (rank : 1045)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	524	Target Neighborhood Hits	860	Shared Neighborhood Hits	84
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

IKKE_HUMAN
NC score	0.054028 (rank : 1046)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	80
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MK01_HUMAN
NC score	0.054021 (rank : 1047)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

TSSK6_MOUSE
NC score	0.054007 (rank : 1048)	θ value	θ > 10 (rank : 1229)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

MK01_MOUSE
NC score	0.053996 (rank : 1049)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	524	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

K0999_MOUSE
NC score	0.053955 (rank : 1050)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	524	Target Neighborhood Hits	931	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MP2K2_HUMAN
NC score	0.053944 (rank : 1051)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	83
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

K0999_HUMAN
NC score	0.053940 (rank : 1052)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	524	Target Neighborhood Hits	899	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MOK_MOUSE
NC score	0.053868 (rank : 1053)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	524	Target Neighborhood Hits	796	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MK03_HUMAN
NC score	0.053824 (rank : 1054)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	524	Target Neighborhood Hits	837	Shared Neighborhood Hits	82
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

KKCC1_HUMAN
NC score	0.053802 (rank : 1055)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	524	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

LAMA5_MOUSE
NC score	0.053800 (rank : 1056)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	54
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

CDKL3_MOUSE
NC score	0.053790 (rank : 1057)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

MARK4_HUMAN
NC score	0.053740 (rank : 1058)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	524	Target Neighborhood Hits	886	Shared Neighborhood Hits	83
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

IKKE_MOUSE
NC score	0.053736 (rank : 1059)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	524	Target Neighborhood Hits	848	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KKCC1_MOUSE
NC score	0.053721 (rank : 1060)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	524	Target Neighborhood Hits	866	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MARK4_MOUSE
NC score	0.053684 (rank : 1061)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	524	Target Neighborhood Hits	898	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

PTN13_HUMAN
NC score	0.053649 (rank : 1062)	θ value	θ > 10 (rank : 1049)
Query Neighborhood Hits	524	Target Neighborhood Hits	471	Shared Neighborhood Hits	21
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

LRC3B_MOUSE
NC score	0.053613 (rank : 1063)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	524	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VCH9	Gene names	Lrrc3b, Lrp15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

MK03_MOUSE
NC score	0.053597 (rank : 1064)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	83
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

PCTK3_MOUSE
NC score	0.053593 (rank : 1065)	θ value	θ > 10 (rank : 1006)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	80
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

TSSK6_HUMAN
NC score	0.053588 (rank : 1066)	θ value	θ > 10 (rank : 1228)
Query Neighborhood Hits	524	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

MK04_MOUSE
NC score	0.053555 (rank : 1067)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	524	Target Neighborhood Hits	852	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MELK_HUMAN
NC score	0.053519 (rank : 1068)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	83
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

LRC3B_HUMAN
NC score	0.053508 (rank : 1069)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	524	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q96PB8	Gene names	LRRC3B, LRP15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

MOK_HUMAN
NC score	0.053453 (rank : 1070)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	524	Target Neighborhood Hits	807	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MP2K1_HUMAN
NC score	0.053413 (rank : 1071)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

TSSK4_MOUSE
NC score	0.053395 (rank : 1072)	θ value	θ > 10 (rank : 1227)
Query Neighborhood Hits	524	Target Neighborhood Hits	840	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

STK10_HUMAN
NC score	0.053392 (rank : 1073)	θ value	θ > 10 (rank : 1158)
Query Neighborhood Hits	524	Target Neighborhood Hits	1921	Shared Neighborhood Hits	90
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

DCAK1_MOUSE
NC score	0.053391 (rank : 1074)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	524	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

MP2K1_MOUSE
NC score	0.053370 (rank : 1075)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

IL12B_MOUSE
NC score	0.053363 (rank : 1076)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	524	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	P43432, Q9QUM1	Gene names	Il12b
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40).

DCAK1_HUMAN
NC score	0.053338 (rank : 1077)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	524	Target Neighborhood Hits	877	Shared Neighborhood Hits	84
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KPSH1_MOUSE
NC score	0.053309 (rank : 1078)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	83
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_HUMAN
NC score	0.053253 (rank : 1079)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

PRKY_HUMAN
NC score	0.053244 (rank : 1080)	θ value	θ > 10 (rank : 1040)
Query Neighborhood Hits	524	Target Neighborhood Hits	844	Shared Neighborhood Hits	83
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

GRK4_HUMAN
NC score	0.053103 (rank : 1081)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

PDK1L_MOUSE
NC score	0.053088 (rank : 1082)	θ value	θ > 10 (rank : 1008)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	82
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

KCC1B_MOUSE
NC score	0.053076 (rank : 1083)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

NIM1_MOUSE
NC score	0.052983 (rank : 1084)	θ value	θ > 10 (rank : 973)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TAOK2_MOUSE
NC score	0.052971 (rank : 1085)	θ value	θ > 10 (rank : 1182)
Query Neighborhood Hits	524	Target Neighborhood Hits	1373	Shared Neighborhood Hits	85
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

CDKL4_HUMAN
NC score	0.052963 (rank : 1086)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	81
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

TSSK1_MOUSE
NC score	0.052902 (rank : 1087)	θ value	θ > 10 (rank : 1225)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	82
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MP2K2_MOUSE
NC score	0.052843 (rank : 1088)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	524	Target Neighborhood Hits	828	Shared Neighborhood Hits	83
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PCTK3_HUMAN
NC score	0.052821 (rank : 1089)	θ value	θ > 10 (rank : 1005)
Query Neighborhood Hits	524	Target Neighborhood Hits	827	Shared Neighborhood Hits	80
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

KCC1B_HUMAN
NC score	0.052819 (rank : 1090)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	524	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

PDK1L_HUMAN
NC score	0.052811 (rank : 1091)	θ value	θ > 10 (rank : 1007)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

STK35_HUMAN
NC score	0.052705 (rank : 1092)	θ value	θ > 10 (rank : 1167)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

CDK3_MOUSE
NC score	0.052640 (rank : 1093)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	82
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

HUNK_HUMAN
NC score	0.052619 (rank : 1094)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	524	Target Neighborhood Hits	884	Shared Neighborhood Hits	83
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
NC score	0.052567 (rank : 1095)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	524	Target Neighborhood Hits	874	Shared Neighborhood Hits	83
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

KPCA_MOUSE
NC score	0.052351 (rank : 1096)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	524	Target Neighborhood Hits	1067	Shared Neighborhood Hits	83
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SREC2_HUMAN
NC score	0.052348 (rank : 1097)	θ value	θ > 10 (rank : 1151)
Query Neighborhood Hits	524	Target Neighborhood Hits	645	Shared Neighborhood Hits	43
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

TLR11_MOUSE
NC score	0.052229 (rank : 1098)	θ value	θ > 10 (rank : 1197)
Query Neighborhood Hits	524	Target Neighborhood Hits	293	Shared Neighborhood Hits	45
SwissProt Accessions	Q6R5P0	Gene names	Tlr11
Domain Architecture	No domain graphic available
Description	Toll-like receptor 11 precursor.

KPCB_MOUSE
NC score	0.052201 (rank : 1099)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	524	Target Neighborhood Hits	1117	Shared Neighborhood Hits	83
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

AL2S7_HUMAN
NC score	0.052173 (rank : 1100)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	524	Target Neighborhood Hits	831	Shared Neighborhood Hits	82
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

LUM_MOUSE
NC score	0.052164 (rank : 1101)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	524	Target Neighborhood Hits	290	Shared Neighborhood Hits	38
SwissProt Accessions	P51885, Q3TP25, Q99JZ3, Q9CXK0	Gene names	Lum, Lcn, Ldc
Domain Architecture
Description	Lumican precursor (Keratan sulfate proteoglycan lumican) (KSPG lumican).

M3K4_HUMAN
NC score	0.052109 (rank : 1102)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	524	Target Neighborhood Hits	911	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

PFTK1_HUMAN
NC score	0.052074 (rank : 1103)	θ value	θ > 10 (rank : 1012)
Query Neighborhood Hits	524	Target Neighborhood Hits	834	Shared Neighborhood Hits	83
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

M3K8_MOUSE
NC score	0.052062 (rank : 1104)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	524	Target Neighborhood Hits	815	Shared Neighborhood Hits	76
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

LAMA5_HUMAN
NC score	0.052058 (rank : 1105)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	524	Target Neighborhood Hits	976	Shared Neighborhood Hits	54
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

PFTK1_MOUSE
NC score	0.052026 (rank : 1106)	θ value	θ > 10 (rank : 1013)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	83
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

CDKL5_HUMAN
NC score	0.052000 (rank : 1107)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	524	Target Neighborhood Hits	967	Shared Neighborhood Hits	87
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

KPCB_HUMAN
NC score	0.051915 (rank : 1108)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	524	Target Neighborhood Hits	1121	Shared Neighborhood Hits	83
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

GRK6_HUMAN
NC score	0.051899 (rank : 1109)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	524	Target Neighborhood Hits	823	Shared Neighborhood Hits	83
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KCC1G_HUMAN
NC score	0.051897 (rank : 1110)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

M4K3_HUMAN
NC score	0.051888 (rank : 1111)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	524	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

KCC1G_MOUSE
NC score	0.051880 (rank : 1112)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	524	Target Neighborhood Hits	851	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

TLR7_MOUSE
NC score	0.051862 (rank : 1113)	θ value	θ > 10 (rank : 1206)
Query Neighborhood Hits	524	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	P58681, Q923I1	Gene names	Tlr7
Domain Architecture
Description	Toll-like receptor 7 precursor.

PRELP_HUMAN
NC score	0.051819 (rank : 1114)	θ value	θ > 10 (rank : 1037)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	40
SwissProt Accessions	P51888	Gene names	PRELP
Domain Architecture
Description	Prolargin precursor (Proline-arginine-rich end leucine-rich repeat protein).

PRELP_MOUSE
NC score	0.051753 (rank : 1115)	θ value	θ > 10 (rank : 1038)
Query Neighborhood Hits	524	Target Neighborhood Hits	295	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JK53	Gene names	Prelp
Domain Architecture
Description	Prolargin precursor (Proline-arginine-rich end leucine-rich repeat protein).

KCC1D_MOUSE
NC score	0.051745 (rank : 1116)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	524	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

GRK6_MOUSE
NC score	0.051729 (rank : 1117)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	524	Target Neighborhood Hits	820	Shared Neighborhood Hits	83
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

TACT_HUMAN
NC score	0.051702 (rank : 1118)	θ value	θ > 10 (rank : 1180)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

SLIK3_HUMAN
NC score	0.051673 (rank : 1119)	θ value	θ > 10 (rank : 1129)
Query Neighborhood Hits	524	Target Neighborhood Hits	298	Shared Neighborhood Hits	42
SwissProt Accessions	O94933	Gene names	SLITRK3, KIAA0848
Domain Architecture	No domain graphic available
Description	SLIT and NTRK-like protein 3 precursor.

IRAK2_HUMAN
NC score	0.051584 (rank : 1120)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	524	Target Neighborhood Hits	714	Shared Neighborhood Hits	67
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

SLIK3_MOUSE
NC score	0.051571 (rank : 1121)	θ value	θ > 10 (rank : 1130)
Query Neighborhood Hits	524	Target Neighborhood Hits	308	Shared Neighborhood Hits	42
SwissProt Accessions	Q810B9	Gene names	Slitrk3
Domain Architecture
Description	SLIT and NTRK-like protein 3 precursor.

KCC1D_HUMAN
NC score	0.051547 (rank : 1122)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

TSSK2_HUMAN
NC score	0.051506 (rank : 1123)	θ value	θ > 10 (rank : 1226)
Query Neighborhood Hits	524	Target Neighborhood Hits	826	Shared Neighborhood Hits	81
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

BRSK2_HUMAN
NC score	0.051481 (rank : 1124)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	524	Target Neighborhood Hits	897	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

SLIK5_HUMAN
NC score	0.051471 (rank : 1125)	θ value	θ > 10 (rank : 1133)
Query Neighborhood Hits	524	Target Neighborhood Hits	302	Shared Neighborhood Hits	43
SwissProt Accessions	O94991	Gene names	SLITRK5, KIAA0918, LRRC11
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor (Leucine-rich repeat-containing protein 11).

SCYL2_MOUSE
NC score	0.051462 (rank : 1126)	θ value	θ > 10 (rank : 1119)
Query Neighborhood Hits	524	Target Neighborhood Hits	603	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

MK15_HUMAN
NC score	0.051430 (rank : 1127)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	524	Target Neighborhood Hits	1038	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

PRKX_MOUSE
NC score	0.051398 (rank : 1128)	θ value	θ > 10 (rank : 1039)
Query Neighborhood Hits	524	Target Neighborhood Hits	846	Shared Neighborhood Hits	83
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

TTK_HUMAN
NC score	0.051350 (rank : 1129)	θ value	θ > 10 (rank : 1230)
Query Neighborhood Hits	524	Target Neighborhood Hits	816	Shared Neighborhood Hits	78
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

WEE1_MOUSE
NC score	0.051247 (rank : 1130)	θ value	θ > 10 (rank : 1245)
Query Neighborhood Hits	524	Target Neighborhood Hits	794	Shared Neighborhood Hits	72
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

CD4_MOUSE
NC score	0.051233 (rank : 1131)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P06332	Gene names	Cd4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4).

CDK9_HUMAN
NC score	0.051208 (rank : 1132)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

M4K4_HUMAN
NC score	0.051195 (rank : 1133)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	524	Target Neighborhood Hits	1589	Shared Neighborhood Hits	85
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

CD79B_HUMAN
NC score	0.051160 (rank : 1134)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	524	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	P40259, Q9BU06	Gene names	CD79B, B29, IGB
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

KPCA_HUMAN
NC score	0.051030 (rank : 1135)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	524	Target Neighborhood Hits	1070	Shared Neighborhood Hits	83
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

OMD_HUMAN
NC score	0.051028 (rank : 1136)	θ value	θ > 10 (rank : 984)
Query Neighborhood Hits	524	Target Neighborhood Hits	275	Shared Neighborhood Hits	39
SwissProt Accessions	Q99983	Gene names	OMD
Domain Architecture
Description	Osteomodulin precursor (Osteoadherin) (OSAD) (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin).

CDK9_MOUSE
NC score	0.051012 (rank : 1137)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	524	Target Neighborhood Hits	822	Shared Neighborhood Hits	83
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CHK1_HUMAN
NC score	0.051010 (rank : 1138)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	83
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

TBK1_HUMAN
NC score	0.050990 (rank : 1139)	θ value	θ > 10 (rank : 1183)
Query Neighborhood Hits	524	Target Neighborhood Hits	861	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

CCRK_HUMAN
NC score	0.050989 (rank : 1140)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	524	Target Neighborhood Hits	835	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CHK1_MOUSE
NC score	0.050988 (rank : 1141)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	524	Target Neighborhood Hits	839	Shared Neighborhood Hits	82
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MK11_HUMAN
NC score	0.050985 (rank : 1142)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	524	Target Neighborhood Hits	823	Shared Neighborhood Hits	81
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

GRK5_MOUSE
NC score	0.050948 (rank : 1143)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	524	Target Neighborhood Hits	823	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

M3K4_MOUSE
NC score	0.050939 (rank : 1144)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	524	Target Neighborhood Hits	924	Shared Neighborhood Hits	81
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

CDKL1_HUMAN
NC score	0.050925 (rank : 1145)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	81
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

BRSK1_HUMAN
NC score	0.050878 (rank : 1146)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	524	Target Neighborhood Hits	942	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

GRK5_HUMAN
NC score	0.050874 (rank : 1147)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	524	Target Neighborhood Hits	819	Shared Neighborhood Hits	83
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

M3K2_HUMAN
NC score	0.050800 (rank : 1148)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MK12_HUMAN
NC score	0.050771 (rank : 1149)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	524	Target Neighborhood Hits	830	Shared Neighborhood Hits	82
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

SREC_HUMAN
NC score	0.050721 (rank : 1150)	θ value	θ > 10 (rank : 1152)
Query Neighborhood Hits	524	Target Neighborhood Hits	645	Shared Neighborhood Hits	37
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

KS6B1_MOUSE
NC score	0.050716 (rank : 1151)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	524	Target Neighborhood Hits	849	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

SLIK5_MOUSE
NC score	0.050709 (rank : 1152)	θ value	θ > 10 (rank : 1134)
Query Neighborhood Hits	524	Target Neighborhood Hits	301	Shared Neighborhood Hits	43
SwissProt Accessions	Q810B7, Q9CT21	Gene names	Slitrk5
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor.

SLIK4_HUMAN
NC score	0.050679 (rank : 1153)	θ value	θ > 10 (rank : 1131)
Query Neighborhood Hits	524	Target Neighborhood Hits	287	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IW52, Q8TCM8, Q96DL3	Gene names	SLITRK4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

KS6B1_HUMAN
NC score	0.050667 (rank : 1154)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	524	Target Neighborhood Hits	850	Shared Neighborhood Hits	83
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

MK14_HUMAN
NC score	0.050661 (rank : 1155)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	524	Target Neighborhood Hits	838	Shared Neighborhood Hits	82
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

SLIK4_MOUSE
NC score	0.050656 (rank : 1156)	θ value	θ > 10 (rank : 1132)
Query Neighborhood Hits	524	Target Neighborhood Hits	292	Shared Neighborhood Hits	42
SwissProt Accessions	Q810B8, Q8BL56, Q8BWB0, Q8BYG4, Q8C056	Gene names	Slitrk4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

PINK1_HUMAN
NC score	0.050643 (rank : 1157)	θ value	θ > 10 (rank : 1019)
Query Neighborhood Hits	524	Target Neighborhood Hits	741	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

MK13_HUMAN
NC score	0.050606 (rank : 1158)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	82
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

DCAK3_HUMAN
NC score	0.050571 (rank : 1159)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	85
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

TBK1_MOUSE
NC score	0.050570 (rank : 1160)	θ value	θ > 10 (rank : 1184)
Query Neighborhood Hits	524	Target Neighborhood Hits	893	Shared Neighborhood Hits	80
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

MK13_MOUSE
NC score	0.050517 (rank : 1161)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	524	Target Neighborhood Hits	832	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

M4K2_MOUSE
NC score	0.050366 (rank : 1162)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	524	Target Neighborhood Hits	843	Shared Neighborhood Hits	82
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

MK06_MOUSE
NC score	0.050290 (rank : 1163)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	524	Target Neighborhood Hits	818	Shared Neighborhood Hits	77
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK06_HUMAN
NC score	0.050278 (rank : 1164)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	524	Target Neighborhood Hits	815	Shared Neighborhood Hits	77
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MEGF9_HUMAN
NC score	0.050265 (rank : 1165)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	524	Target Neighborhood Hits	557	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

SCYL2_HUMAN
NC score	0.050120 (rank : 1166)	θ value	θ > 10 (rank : 1118)
Query Neighborhood Hits	524	Target Neighborhood Hits	632	Shared Neighborhood Hits	66
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

CDKL1_MOUSE
NC score	0.050119 (rank : 1167)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	524	Target Neighborhood Hits	829	Shared Neighborhood Hits	81
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

SLIK1_HUMAN
NC score	0.050112 (rank : 1168)	θ value	θ > 10 (rank : 1127)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PX8, Q5U5I6, Q96SF9	Gene names	SLITRK1, KIAA1910, LRRC12
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor (Leucine-rich repeat-containing protein 12).

CI096_HUMAN
NC score	0.050102 (rank : 1169)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	524	Target Neighborhood Hits	821	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

LIRA3_HUMAN
NC score	0.050086 (rank : 1170)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	524	Target Neighborhood Hits	92	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N6C8, O15469, O15470, O75016, Q8N151, Q8N154, Q8NHJ1, Q8NHJ2, Q8NHJ3, Q8NHJ4	Gene names	LILRA3, ILT6, LIR4
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily A member 3 precursor (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Immunoglobulin- like transcript 6) (ILT-6) (Monocyte inhibitory receptor HM43/HM31) (CD85e antigen).

SLIK1_MOUSE
NC score	0.050066 (rank : 1171)	θ value	θ > 10 (rank : 1128)
Query Neighborhood Hits	524	Target Neighborhood Hits	333	Shared Neighborhood Hits	42
SwissProt Accessions	Q810C1, Q9CXL0	Gene names	Slitrk1, Sltk1
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor.

BTNL8_HUMAN
NC score	0.049868 (rank : 1172)	θ value	4.03905 (rank : 454)
Query Neighborhood Hits	524	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

BT2A3_HUMAN
NC score	0.049024 (rank : 1173)	θ value	0.279714 (rank : 377)
Query Neighborhood Hits	524	Target Neighborhood Hits	195	Shared Neighborhood Hits	72
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

HPLN2_MOUSE
NC score	0.047416 (rank : 1174)	θ value	1.81305 (rank : 421)
Query Neighborhood Hits	524	Target Neighborhood Hits	102	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESM3	Gene names	Hapln2, Bral1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

SEM4D_HUMAN
NC score	0.045561 (rank : 1175)	θ value	1.06291 (rank : 409)
Query Neighborhood Hits	524	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q92854, Q7Z5S4	Gene names	SEMA4D, CD100
Domain Architecture
Description	Semaphorin-4D precursor (Leukocyte activation antigen CD100) (BB18) (A8) (GR3).

MADCA_MOUSE
NC score	0.042712 (rank : 1176)	θ value	2.36792 (rank : 430)
Query Neighborhood Hits	524	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

KPCI_MOUSE
NC score	0.041258 (rank : 1177)	θ value	8.99809 (rank : 518)
Query Neighborhood Hits	524	Target Neighborhood Hits	888	Shared Neighborhood Hits	84
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCI_HUMAN
NC score	0.041204 (rank : 1178)	θ value	8.99809 (rank : 517)
Query Neighborhood Hits	524	Target Neighborhood Hits	885	Shared Neighborhood Hits	84
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

TIMD3_HUMAN
NC score	0.040797 (rank : 1179)	θ value	5.27518 (rank : 487)
Query Neighborhood Hits	524	Target Neighborhood Hits	62	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TDQ0, Q8WW60, Q96K94	Gene names	HAVCR2, TIM3, TIMD3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

CD8A_MOUSE
NC score	0.035933 (rank : 1180)	θ value	8.99809 (rank : 512)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	P01731	Gene names	Cd8a, Lyt-2, Lyt2
Domain Architecture
Description	T-cell surface glycoprotein CD8 alpha chain precursor (T-cell surface glycoprotein Lyt-2) (CD8a antigen).

SEM3C_MOUSE
NC score	0.035803 (rank : 1181)	θ value	4.03905 (rank : 468)
Query Neighborhood Hits	524	Target Neighborhood Hits	113	Shared Neighborhood Hits	55
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

TRI18_HUMAN
NC score	0.034033 (rank : 1182)	θ value	1.06291 (rank : 411)
Query Neighborhood Hits	524	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

BT2A2_HUMAN
NC score	0.033520 (rank : 1183)	θ value	5.27518 (rank : 470)
Query Neighborhood Hits	524	Target Neighborhood Hits	191	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

TRIM1_MOUSE
NC score	0.032651 (rank : 1184)	θ value	5.27518 (rank : 488)
Query Neighborhood Hits	524	Target Neighborhood Hits	361	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

BT2A1_HUMAN
NC score	0.032297 (rank : 1185)	θ value	4.03905 (rank : 453)
Query Neighborhood Hits	524	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

SEM3C_HUMAN
NC score	0.032191 (rank : 1186)	θ value	1.38821 (rank : 418)
Query Neighborhood Hits	524	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q99985	Gene names	SEMA3C, SEMAE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

MPZL1_HUMAN
NC score	0.028473 (rank : 1187)	θ value	5.27518 (rank : 480)
Query Neighborhood Hits	524	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	O95297, Q5R332, Q8IX11, Q9BWZ3, Q9NYK4, Q9UL20	Gene names	MPZL1, PZR
Domain Architecture	No domain graphic available
Description	Myelin protein zero-like protein 1 precursor (Protein zero-related).

FIBA_HUMAN
NC score	0.028239 (rank : 1188)	θ value	4.03905 (rank : 458)
Query Neighborhood Hits	524	Target Neighborhood Hits	132	Shared Neighborhood Hits	10
SwissProt Accessions	P02671, Q9BX62, Q9UCH2	Gene names	FGA
Domain Architecture
Description	Fibrinogen alpha chain precursor [Contains: Fibrinopeptide A].

NCTR2_HUMAN
NC score	0.027636 (rank : 1189)	θ value	8.99809 (rank : 522)
Query Neighborhood Hits	524	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	O95944, Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2	Gene names	NCR2, LY95
Domain Architecture
Description	Natural cytotoxicity triggering receptor 2 precursor (Natural killer cell p44-related protein) (NKp44) (NK-p44) (NK cell-activating receptor) (Lymphocyte antigen 95 homolog) (CD336 antigen).

SEM3F_HUMAN
NC score	0.024837 (rank : 1190)	θ value	6.88961 (rank : 503)
Query Neighborhood Hits	524	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	Q13275, Q13274, Q13372, Q15704	Gene names	SEMA3F
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV) (Sema III/F).

EPN2_HUMAN
NC score	0.023770 (rank : 1191)	θ value	0.00390308 (rank : 321)
Query Neighborhood Hits	524	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

ZPBP2_HUMAN
NC score	0.021908 (rank : 1192)	θ value	3.0926 (rank : 452)
Query Neighborhood Hits	524	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	Q6X784, Q6X783, Q86XL5	Gene names	ZPBP2, ZPBPL
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 2 precursor (ZPBP-like protein).

SRRM2_MOUSE
NC score	0.021743 (rank : 1193)	θ value	6.88961 (rank : 505)
Query Neighborhood Hits	524	Target Neighborhood Hits	1470	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

NSF1C_HUMAN
NC score	0.019872 (rank : 1194)	θ value	0.279714 (rank : 381)
Query Neighborhood Hits	524	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNZ2, Q7Z533, Q9H102, Q9NVL9, Q9UI06	Gene names	NSFL1C
Domain Architecture
Description	NSFL1 cofactor p47 (p97 cofactor p47).

FCAR_HUMAN
NC score	0.018888 (rank : 1195)	θ value	0.47712 (rank : 395)
Query Neighborhood Hits	524	Target Neighborhood Hits	52	Shared Neighborhood Hits	15
SwissProt Accessions	P24071, Q13603, Q13604, Q15727, Q15728, Q92590	Gene names	FCAR, CD89
Domain Architecture	No domain graphic available
Description	Immunoglobulin alpha Fc receptor precursor (IgA Fc receptor) (CD89 antigen).

NSF1C_MOUSE
NC score	0.017846 (rank : 1196)	θ value	0.813845 (rank : 403)
Query Neighborhood Hits	524	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZ44, Q80Y15, Q8BYL3	Gene names	Nsfl1c
Domain Architecture
Description	NSFL1 cofactor p47 (p97 cofactor p47).

EPN2_MOUSE
NC score	0.017452 (rank : 1197)	θ value	0.365318 (rank : 386)
Query Neighborhood Hits	524	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHU3, O70447, Q8BZ85	Gene names	Epn2
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2) (Intersectin-EH-binding protein 2) (Ibp2).

KV5D_MOUSE
NC score	0.017324 (rank : 1198)	θ value	3.0926 (rank : 441)
Query Neighborhood Hits	524	Target Neighborhood Hits	255	Shared Neighborhood Hits	56
SwissProt Accessions	P01636	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region MOPC 149.

SRRM2_HUMAN
NC score	0.016519 (rank : 1199)	θ value	5.27518 (rank : 485)
Query Neighborhood Hits	524	Target Neighborhood Hits	1296	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

KV5E_MOUSE
NC score	0.015817 (rank : 1200)	θ value	1.06291 (rank : 408)
Query Neighborhood Hits	524	Target Neighborhood Hits	249	Shared Neighborhood Hits	49
SwissProt Accessions	P01637	Gene names
Domain Architecture
Description	Ig kappa chain V-V region T1 precursor.

KV1Q_HUMAN
NC score	0.014279 (rank : 1201)	θ value	3.0926 (rank : 437)
Query Neighborhood Hits	524	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	P01609	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Scw.

KV5B_MOUSE
NC score	0.014004 (rank : 1202)	θ value	3.0926 (rank : 440)
Query Neighborhood Hits	524	Target Neighborhood Hits	253	Shared Neighborhood Hits	55
SwissProt Accessions	P01634	Gene names
Domain Architecture
Description	Ig kappa chain V-V region MOPC 21 precursor.

KV5O_MOUSE
NC score	0.013019 (rank : 1203)	θ value	6.88961 (rank : 497)
Query Neighborhood Hits	524	Target Neighborhood Hits	211	Shared Neighborhood Hits	44
SwissProt Accessions	P01648	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region HP 91A3.

KV3H_HUMAN
NC score	0.012902 (rank : 1204)	θ value	8.99809 (rank : 521)
Query Neighborhood Hits	524	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	P04207	Gene names
Domain Architecture
Description	Ig kappa chain V-III region CLL precursor (Rheumatoid factor).

CELR3_MOUSE
NC score	0.012088 (rank : 1205)	θ value	8.99809 (rank : 514)
Query Neighborhood Hits	524	Target Neighborhood Hits	687	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZI0, Q9ESD0	Gene names	Celsr3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor.

CTLA4_MOUSE
NC score	0.011800 (rank : 1206)	θ value	5.27518 (rank : 471)
Query Neighborhood Hits	524	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P09793, Q9QZZ7	Gene names	Ctla4, Cd152
Domain Architecture
Description	Cytotoxic T-lymphocyte protein 4 precursor (Cytotoxic T-lymphocyte- associated antigen 4) (CTLA-4) (CD152 antigen).

KV1M_HUMAN
NC score	0.011784 (rank : 1207)	θ value	5.27518 (rank : 478)
Query Neighborhood Hits	524	Target Neighborhood Hits	249	Shared Neighborhood Hits	47
SwissProt Accessions	P01605	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Lay.

KV1H_HUMAN
NC score	0.011596 (rank : 1208)	θ value	1.38821 (rank : 415)
Query Neighborhood Hits	524	Target Neighborhood Hits	283	Shared Neighborhood Hits	47
SwissProt Accessions	P01600	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Hau.

KV1A_HUMAN
NC score	0.011548 (rank : 1209)	θ value	1.38821 (rank : 414)
Query Neighborhood Hits	524	Target Neighborhood Hits	203	Shared Neighborhood Hits	38
SwissProt Accessions	P01593	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region AG.

IL9R_MOUSE
NC score	0.011505 (rank : 1210)	θ value	5.27518 (rank : 474)
Query Neighborhood Hits	524	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q01114	Gene names	Il9r
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

TARA_HUMAN
NC score	0.011144 (rank : 1211)	θ value	0.365318 (rank : 390)
Query Neighborhood Hits	524	Target Neighborhood Hits	1626	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

LSHR_HUMAN
NC score	0.011109 (rank : 1212)	θ value	2.36792 (rank : 429)
Query Neighborhood Hits	524	Target Neighborhood Hits	731	Shared Neighborhood Hits	31
SwissProt Accessions	P22888, Q14751, Q15996, Q9UEW9	Gene names	LHCGR, LCGR, LGR2, LHRHR
Domain Architecture
Description	Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH- R) (Luteinizing hormone receptor) (LHR).

KV1G_HUMAN
NC score	0.010691 (rank : 1213)	θ value	8.99809 (rank : 519)
Query Neighborhood Hits	524	Target Neighborhood Hits	241	Shared Neighborhood Hits	45
SwissProt Accessions	P01599	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Gal.

KV1C_HUMAN
NC score	0.010367 (rank : 1214)	θ value	3.0926 (rank : 436)
Query Neighborhood Hits	524	Target Neighborhood Hits	257	Shared Neighborhood Hits	44
SwissProt Accessions	P01595	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Bi.

KV1S_HUMAN
NC score	0.010347 (rank : 1215)	θ value	6.88961 (rank : 496)
Query Neighborhood Hits	524	Target Neighborhood Hits	237	Shared Neighborhood Hits	46
SwissProt Accessions	P01611	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Wes.

KV1O_HUMAN
NC score	0.010080 (rank : 1216)	θ value	4.03905 (rank : 460)
Query Neighborhood Hits	524	Target Neighborhood Hits	251	Shared Neighborhood Hits	40
SwissProt Accessions	P01607	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Rei.

R3HD1_HUMAN
NC score	0.009926 (rank : 1217)	θ value	4.03905 (rank : 466)
Query Neighborhood Hits	524	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

KV1F_HUMAN
NC score	0.009430 (rank : 1218)	θ value	5.27518 (rank : 476)
Query Neighborhood Hits	524	Target Neighborhood Hits	261	Shared Neighborhood Hits	42
SwissProt Accessions	P01598	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region EU.

KV1E_HUMAN
NC score	0.009029 (rank : 1219)	θ value	2.36792 (rank : 428)
Query Neighborhood Hits	524	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	P01597	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region DEE.

KV1T_HUMAN
NC score	0.008839 (rank : 1220)	θ value	3.0926 (rank : 438)
Query Neighborhood Hits	524	Target Neighborhood Hits	256	Shared Neighborhood Hits	40
SwissProt Accessions	P01612	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Mev.

KV1R_HUMAN
NC score	0.008584 (rank : 1221)	θ value	8.99809 (rank : 520)
Query Neighborhood Hits	524	Target Neighborhood Hits	253	Shared Neighborhood Hits	42
SwissProt Accessions	P01610	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region WEA.

KV1W_HUMAN
NC score	0.008581 (rank : 1222)	θ value	3.0926 (rank : 439)
Query Neighborhood Hits	524	Target Neighborhood Hits	299	Shared Neighborhood Hits	47
SwissProt Accessions	P04431	Gene names
Domain Architecture
Description	Ig kappa chain V-I region Walker precursor.

KV1B_HUMAN
NC score	0.008565 (rank : 1223)	θ value	1.81305 (rank : 423)
Query Neighborhood Hits	524	Target Neighborhood Hits	244	Shared Neighborhood Hits	35
SwissProt Accessions	P01594	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region AU.

SGOL2_MOUSE
NC score	0.008436 (rank : 1224)	θ value	2.36792 (rank : 431)
Query Neighborhood Hits	524	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55	Gene names	Sgol2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2.

TDP1_MOUSE
NC score	0.008366 (rank : 1225)	θ value	2.36792 (rank : 433)
Query Neighborhood Hits	524	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q08639	Gene names	Tfdp1
Domain Architecture
Description	Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1- polypeptide 1).

KV1X_HUMAN
NC score	0.008229 (rank : 1226)	θ value	4.03905 (rank : 461)
Query Neighborhood Hits	524	Target Neighborhood Hits	243	Shared Neighborhood Hits	40
SwissProt Accessions	P04432	Gene names
Domain Architecture
Description	Ig kappa chain V-I region Daudi precursor.

SEM3B_MOUSE
NC score	0.007896 (rank : 1227)	θ value	6.88961 (rank : 502)
Query Neighborhood Hits	524	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q62177	Gene names	Sema3b, Sema, Semaa
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin A) (Sema A).

SEM3B_HUMAN
NC score	0.007500 (rank : 1228)	θ value	4.03905 (rank : 467)
Query Neighborhood Hits	524	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).

TTLL4_HUMAN
NC score	0.006843 (rank : 1229)	θ value	3.0926 (rank : 447)
Query Neighborhood Hits	524	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q14679, Q8WW29	Gene names	TTLL4, KIAA0173
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 4.

KV1D_HUMAN
NC score	0.005952 (rank : 1230)	θ value	5.27518 (rank : 475)
Query Neighborhood Hits	524	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P01596	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region CAR.

2DMB_HUMAN
NC score	0.005838 (rank : 1231)	θ value	6.88961 (rank : 490)
Query Neighborhood Hits	524	Target Neighborhood Hits	216	Shared Neighborhood Hits	22
SwissProt Accessions	P28068, O77936, Q13012, Q29751, Q9XRX2	Gene names	HLA-DMB, DMB, RING7
Domain Architecture
Description	HLA class II histocompatibility antigen, DM beta chain precursor (MHC class II antigen DMB).

KV1K_HUMAN
NC score	0.005804 (rank : 1232)	θ value	5.27518 (rank : 477)
Query Neighborhood Hits	524	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	P01603	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Ka.

KV5P_MOUSE
NC score	0.005569 (rank : 1233)	θ value	6.88961 (rank : 498)
Query Neighborhood Hits	524	Target Neighborhood Hits	193	Shared Neighborhood Hits	32
SwissProt Accessions	P01649	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V regions (Anti-arsonate antibodies).

TTLL4_MOUSE
NC score	0.004685 (rank : 1234)	θ value	5.27518 (rank : 489)
Query Neighborhood Hits	524	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

UBDC1_MOUSE
NC score	0.003950 (rank : 1235)	θ value	6.88961 (rank : 507)
Query Neighborhood Hits	524	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDI7, Q3TZH3	Gene names	Ubadc1, Kpc2
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated domain-containing protein 1 (E3 ubiquitin-protein ligase subunit KPC2) (Kip1 ubiquitination-promoting complex protein 2).

LV2C_HUMAN
NC score	0.003924 (rank : 1236)	θ value	6.88961 (rank : 499)
Query Neighborhood Hits	524	Target Neighborhood Hits	257	Shared Neighborhood Hits	34
SwissProt Accessions	P01706	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region BOH.

MPIP2_MOUSE
NC score	0.003827 (rank : 1237)	θ value	4.03905 (rank : 463)
Query Neighborhood Hits	524	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P30306, Q99LP3	Gene names	Cdc25b, Cdc25m2
Domain Architecture
Description	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B).

TARA_MOUSE
NC score	0.003261 (rank : 1238)	θ value	6.88961 (rank : 506)
Query Neighborhood Hits	524	Target Neighborhood Hits	1133	Shared Neighborhood Hits	22
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

IRS1_HUMAN
NC score	0.003010 (rank : 1239)	θ value	6.88961 (rank : 494)
Query Neighborhood Hits	524	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

JHD3B_MOUSE
NC score	0.002284 (rank : 1240)	θ value	6.88961 (rank : 495)
Query Neighborhood Hits	524	Target Neighborhood Hits	152	Shared Neighborhood Hits	9
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

ANLN_MOUSE
NC score	0.001942 (rank : 1241)	θ value	8.99809 (rank : 510)
Query Neighborhood Hits	524	Target Neighborhood Hits	297	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

BCAR1_HUMAN
NC score	0.001622 (rank : 1242)	θ value	6.88961 (rank : 491)
Query Neighborhood Hits	524	Target Neighborhood Hits	554	Shared Neighborhood Hits	11
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

MAML1_MOUSE
NC score	0.000641 (rank : 1243)	θ value	6.88961 (rank : 500)
Query Neighborhood Hits	524	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

AKA12_HUMAN
NC score	0.000541 (rank : 1244)	θ value	8.99809 (rank : 508)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	12
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

CTND1_MOUSE
NC score	0.000359 (rank : 1245)	θ value	8.99809 (rank : 515)
Query Neighborhood Hits	524	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

PKHA6_MOUSE
NC score	-0.000865 (rank : 1246)	θ value	8.99809 (rank : 523)
Query Neighborhood Hits	524	Target Neighborhood Hits	591	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

HRX_HUMAN
NC score	-0.002385 (rank : 1247)	θ value	5.27518 (rank : 473)
Query Neighborhood Hits	524	Target Neighborhood Hits	825	Shared Neighborhood Hits	15
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MDR1_MOUSE
NC score	-0.003078 (rank : 1248)	θ value	5.27518 (rank : 479)
Query Neighborhood Hits	524	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	P06795	Gene names	Abcb1, Abcb1b, Mdr1, Mdr1b, Pgy1, Pgy1-1
Domain Architecture
Description	Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD243 antigen).

PCD16_HUMAN
NC score	-0.003813 (rank : 1249)	θ value	4.03905 (rank : 464)
Query Neighborhood Hits	524	Target Neighborhood Hits	245	Shared Neighborhood Hits	11
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

HV1D_HUMAN
NC score	-0.004182 (rank : 1250)	θ value	8.99809 (rank : 516)
Query Neighborhood Hits	524	Target Neighborhood Hits	183	Shared Neighborhood Hits	18
SwissProt Accessions	P01760	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V-I region WOL.