Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PTPRD_HUMAN

For an explanation of this page, click here

PTPRD_HUMAN
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PTPRD_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	485	Target Neighborhood Hits	485	Shared Neighborhood Hits	485
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	0 (rank : 2)	NC score	0.996969 (rank : 2)
Query Neighborhood Hits	485	Target Neighborhood Hits	491	Shared Neighborhood Hits	450
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
θ value	0 (rank : 3)	NC score	0.993287 (rank : 4)
Query Neighborhood Hits	485	Target Neighborhood Hits	489	Shared Neighborhood Hits	428
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRS_HUMAN
θ value	0 (rank : 4)	NC score	0.994339 (rank : 3)
Query Neighborhood Hits	485	Target Neighborhood Hits	472	Shared Neighborhood Hits	423
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRA_HUMAN
θ value	5.36813e-170 (rank : 5)	NC score	0.715827 (rank : 29)
Query Neighborhood Hits	485	Target Neighborhood Hits	101	Shared Neighborhood Hits	74
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	3.72618e-163 (rank : 6)	NC score	0.715272 (rank : 30)
Query Neighborhood Hits	485	Target Neighborhood Hits	93	Shared Neighborhood Hits	74
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRE_MOUSE
θ value	8.88953e-157 (rank : 7)	NC score	0.716057 (rank : 27)
Query Neighborhood Hits	485	Target Neighborhood Hits	86	Shared Neighborhood Hits	73
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_HUMAN
θ value	1.98038e-156 (rank : 8)	NC score	0.715837 (rank : 28)
Query Neighborhood Hits	485	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRM_MOUSE
θ value	3.62588e-142 (rank : 9)	NC score	0.839763 (rank : 6)
Query Neighborhood Hits	485	Target Neighborhood Hits	238	Shared Neighborhood Hits	210
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_HUMAN
θ value	6.18479e-142 (rank : 10)	NC score	0.841256 (rank : 5)
Query Neighborhood Hits	485	Target Neighborhood Hits	244	Shared Neighborhood Hits	212
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRK_HUMAN
θ value	5.78879e-140 (rank : 11)	NC score	0.802653 (rank : 11)
Query Neighborhood Hits	485	Target Neighborhood Hits	228	Shared Neighborhood Hits	188
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRT_MOUSE
θ value	1.86219e-138 (rank : 12)	NC score	0.826303 (rank : 7)
Query Neighborhood Hits	485	Target Neighborhood Hits	219	Shared Neighborhood Hits	187
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRK_MOUSE
θ value	1.20704e-137 (rank : 13)	NC score	0.804169 (rank : 10)
Query Neighborhood Hits	485	Target Neighborhood Hits	223	Shared Neighborhood Hits	187
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRT_HUMAN
θ value	4.58675e-137 (rank : 14)	NC score	0.825687 (rank : 8)
Query Neighborhood Hits	485	Target Neighborhood Hits	217	Shared Neighborhood Hits	186
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRG_HUMAN
θ value	2.69525e-129 (rank : 15)	NC score	0.656299 (rank : 80)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	110
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	3.5201e-129 (rank : 16)	NC score	0.653017 (rank : 84)
Query Neighborhood Hits	485	Target Neighborhood Hits	260	Shared Neighborhood Hits	107
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRU_HUMAN
θ value	8.97236e-125 (rank : 17)	NC score	0.813929 (rank : 9)
Query Neighborhood Hits	485	Target Neighborhood Hits	237	Shared Neighborhood Hits	207
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRZ_HUMAN
θ value	1.63895e-118 (rank : 18)	NC score	0.654292 (rank : 83)
Query Neighborhood Hits	485	Target Neighborhood Hits	255	Shared Neighborhood Hits	91
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

CD45_HUMAN
θ value	2.80211e-110 (rank : 19)	NC score	0.726996 (rank : 24)
Query Neighborhood Hits	485	Target Neighborhood Hits	243	Shared Neighborhood Hits	111
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	1.48926e-103 (rank : 20)	NC score	0.725689 (rank : 25)
Query Neighborhood Hits	485	Target Neighborhood Hits	178	Shared Neighborhood Hits	102
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

SDK1_HUMAN
θ value	8.51556e-75 (rank : 21)	NC score	0.731690 (rank : 23)
Query Neighborhood Hits	485	Target Neighborhood Hits	511	Shared Neighborhood Hits	367
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
θ value	5.51964e-74 (rank : 22)	NC score	0.733094 (rank : 22)
Query Neighborhood Hits	485	Target Neighborhood Hits	495	Shared Neighborhood Hits	365
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	3.02872e-72 (rank : 23)	NC score	0.736091 (rank : 20)
Query Neighborhood Hits	485	Target Neighborhood Hits	480	Shared Neighborhood Hits	358
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

NEO1_HUMAN
θ value	5.71191e-71 (rank : 24)	NC score	0.745764 (rank : 17)
Query Neighborhood Hits	485	Target Neighborhood Hits	530	Shared Neighborhood Hits	360
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	1.27248e-70 (rank : 25)	NC score	0.747332 (rank : 16)
Query Neighborhood Hits	485	Target Neighborhood Hits	523	Shared Neighborhood Hits	357
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

DCC_HUMAN
θ value	1.66191e-70 (rank : 26)	NC score	0.737436 (rank : 18)
Query Neighborhood Hits	485	Target Neighborhood Hits	583	Shared Neighborhood Hits	363
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

SDK1_MOUSE
θ value	6.31527e-70 (rank : 27)	NC score	0.734793 (rank : 21)
Query Neighborhood Hits	485	Target Neighborhood Hits	495	Shared Neighborhood Hits	366
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

PTPRJ_HUMAN
θ value	1.40689e-69 (rank : 28)	NC score	0.753754 (rank : 14)
Query Neighborhood Hits	485	Target Neighborhood Hits	207	Shared Neighborhood Hits	159
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

DCC_MOUSE
θ value	3.4653e-68 (rank : 29)	NC score	0.720234 (rank : 26)
Query Neighborhood Hits	485	Target Neighborhood Hits	896	Shared Neighborhood Hits	369
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

PTPRV_MOUSE
θ value	5.91091e-68 (rank : 30)	NC score	0.757144 (rank : 13)
Query Neighborhood Hits	485	Target Neighborhood Hits	179	Shared Neighborhood Hits	136
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRB_HUMAN
θ value	1.04338e-64 (rank : 31)	NC score	0.767012 (rank : 12)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	167
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRJ_MOUSE
θ value	1.41016e-61 (rank : 32)	NC score	0.753281 (rank : 15)
Query Neighborhood Hits	485	Target Neighborhood Hits	188	Shared Neighborhood Hits	152
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRO_HUMAN
θ value	3.25095e-58 (rank : 33)	NC score	0.737048 (rank : 19)
Query Neighborhood Hits	485	Target Neighborhood Hits	139	Shared Neighborhood Hits	115
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

DSCL1_HUMAN
θ value	8.00737e-57 (rank : 34)	NC score	0.711290 (rank : 31)
Query Neighborhood Hits	485	Target Neighborhood Hits	589	Shared Neighborhood Hits	354
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DSCAM_HUMAN
θ value	4.85792e-54 (rank : 35)	NC score	0.705179 (rank : 33)
Query Neighborhood Hits	485	Target Neighborhood Hits	524	Shared Neighborhood Hits	350
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

PTN9_HUMAN
θ value	1.01294e-51 (rank : 36)	NC score	0.672378 (rank : 57)
Query Neighborhood Hits	485	Target Neighborhood Hits	79	Shared Neighborhood Hits	67
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	1.32293e-51 (rank : 37)	NC score	0.672858 (rank : 56)
Query Neighborhood Hits	485	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN6_MOUSE
θ value	3.84914e-51 (rank : 38)	NC score	0.637205 (rank : 87)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN6_HUMAN
θ value	1.23823e-49 (rank : 39)	NC score	0.638463 (rank : 86)
Query Neighborhood Hits	485	Target Neighborhood Hits	234	Shared Neighborhood Hits	72
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN11_HUMAN
θ value	8.02596e-49 (rank : 40)	NC score	0.622914 (rank : 93)
Query Neighborhood Hits	485	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	8.02596e-49 (rank : 41)	NC score	0.622919 (rank : 92)
Query Neighborhood Hits	485	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

CNTN2_HUMAN
θ value	1.04822e-48 (rank : 42)	NC score	0.683762 (rank : 38)
Query Neighborhood Hits	485	Target Neighborhood Hits	440	Shared Neighborhood Hits	340
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

ROBO2_HUMAN
θ value	1.788e-48 (rank : 43)	NC score	0.668898 (rank : 68)
Query Neighborhood Hits	485	Target Neighborhood Hits	479	Shared Neighborhood Hits	338
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

NRCAM_MOUSE
θ value	3.04986e-48 (rank : 44)	NC score	0.703779 (rank : 34)
Query Neighborhood Hits	485	Target Neighborhood Hits	432	Shared Neighborhood Hits	337
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

ROBO2_MOUSE
θ value	1.51363e-47 (rank : 45)	NC score	0.668897 (rank : 69)
Query Neighborhood Hits	485	Target Neighborhood Hits	504	Shared Neighborhood Hits	345
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

PTPR2_MOUSE
θ value	1.97686e-47 (rank : 46)	NC score	0.668494 (rank : 70)
Query Neighborhood Hits	485	Target Neighborhood Hits	120	Shared Neighborhood Hits	68
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

CNTN5_HUMAN
θ value	2.85459e-46 (rank : 47)	NC score	0.683329 (rank : 39)
Query Neighborhood Hits	485	Target Neighborhood Hits	446	Shared Neighborhood Hits	341
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

PTN22_HUMAN
θ value	2.85459e-46 (rank : 48)	NC score	0.671685 (rank : 59)
Query Neighborhood Hits	485	Target Neighborhood Hits	109	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

CNTN2_MOUSE
θ value	4.86918e-46 (rank : 49)	NC score	0.682216 (rank : 40)
Query Neighborhood Hits	485	Target Neighborhood Hits	450	Shared Neighborhood Hits	340
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

NRCAM_HUMAN
θ value	4.86918e-46 (rank : 50)	NC score	0.705583 (rank : 32)
Query Neighborhood Hits	485	Target Neighborhood Hits	439	Shared Neighborhood Hits	343
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

PTN4_HUMAN
θ value	6.35935e-46 (rank : 51)	NC score	0.518143 (rank : 129)
Query Neighborhood Hits	485	Target Neighborhood Hits	303	Shared Neighborhood Hits	77
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTPR2_HUMAN
θ value	6.35935e-46 (rank : 52)	NC score	0.669329 (rank : 67)
Query Neighborhood Hits	485	Target Neighborhood Hits	103	Shared Neighborhood Hits	69
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTN7_HUMAN
θ value	1.41672e-45 (rank : 53)	NC score	0.680814 (rank : 42)
Query Neighborhood Hits	485	Target Neighborhood Hits	75	Shared Neighborhood Hits	67
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	1.85029e-45 (rank : 54)	NC score	0.681207 (rank : 41)
Query Neighborhood Hits	485	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTPRN_MOUSE
θ value	3.15612e-45 (rank : 55)	NC score	0.663091 (rank : 76)
Query Neighborhood Hits	485	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTN13_HUMAN
θ value	9.18288e-45 (rank : 56)	NC score	0.500767 (rank : 141)
Query Neighborhood Hits	485	Target Neighborhood Hits	471	Shared Neighborhood Hits	74
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTPRN_HUMAN
θ value	9.18288e-45 (rank : 57)	NC score	0.665174 (rank : 72)
Query Neighborhood Hits	485	Target Neighborhood Hits	156	Shared Neighborhood Hits	71
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTN2_MOUSE
θ value	1.56636e-44 (rank : 58)	NC score	0.676591 (rank : 47)
Query Neighborhood Hits	485	Target Neighborhood Hits	107	Shared Neighborhood Hits	65
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN2_HUMAN
θ value	2.04573e-44 (rank : 59)	NC score	0.677220 (rank : 46)
Query Neighborhood Hits	485	Target Neighborhood Hits	92	Shared Neighborhood Hits	64
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

ROBO1_HUMAN
θ value	2.67181e-44 (rank : 60)	NC score	0.650788 (rank : 85)
Query Neighborhood Hits	485	Target Neighborhood Hits	529	Shared Neighborhood Hits	332
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

PTN13_MOUSE
θ value	3.48949e-44 (rank : 61)	NC score	0.505158 (rank : 136)
Query Neighborhood Hits	485	Target Neighborhood Hits	426	Shared Neighborhood Hits	77
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

CNTN6_MOUSE
θ value	4.55743e-44 (rank : 62)	NC score	0.655924 (rank : 82)
Query Neighborhood Hits	485	Target Neighborhood Hits	429	Shared Neighborhood Hits	324
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

NFASC_HUMAN
θ value	4.55743e-44 (rank : 63)	NC score	0.689148 (rank : 37)
Query Neighborhood Hits	485	Target Neighborhood Hits	497	Shared Neighborhood Hits	342
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

PTN5_MOUSE
θ value	5.95217e-44 (rank : 64)	NC score	0.676259 (rank : 49)
Query Neighborhood Hits	485	Target Neighborhood Hits	85	Shared Neighborhood Hits	71
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

ROBO1_MOUSE
θ value	7.77379e-44 (rank : 65)	NC score	0.656153 (rank : 81)
Query Neighborhood Hits	485	Target Neighborhood Hits	559	Shared Neighborhood Hits	340
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

PTN1_HUMAN
θ value	1.01529e-43 (rank : 66)	NC score	0.676130 (rank : 51)
Query Neighborhood Hits	485	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

CNTN6_HUMAN
θ value	5.03882e-43 (rank : 67)	NC score	0.664230 (rank : 75)
Query Neighborhood Hits	485	Target Neighborhood Hits	422	Shared Neighborhood Hits	320
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

PTN21_MOUSE
θ value	5.03882e-43 (rank : 68)	NC score	0.557376 (rank : 119)
Query Neighborhood Hits	485	Target Neighborhood Hits	155	Shared Neighborhood Hits	68
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN1_MOUSE
θ value	6.58091e-43 (rank : 69)	NC score	0.676167 (rank : 50)
Query Neighborhood Hits	485	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

CNTN5_MOUSE
θ value	8.59492e-43 (rank : 70)	NC score	0.678226 (rank : 45)
Query Neighborhood Hits	485	Target Neighborhood Hits	434	Shared Neighborhood Hits	333
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

PTN21_HUMAN
θ value	1.91475e-42 (rank : 71)	NC score	0.557941 (rank : 116)
Query Neighborhood Hits	485	Target Neighborhood Hits	143	Shared Neighborhood Hits	67
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN5_HUMAN
θ value	2.50074e-42 (rank : 72)	NC score	0.676120 (rank : 52)
Query Neighborhood Hits	485	Target Neighborhood Hits	80	Shared Neighborhood Hits	73
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN3_HUMAN
θ value	5.57106e-42 (rank : 73)	NC score	0.534820 (rank : 126)
Query Neighborhood Hits	485	Target Neighborhood Hits	258	Shared Neighborhood Hits	78
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

CNTN1_HUMAN
θ value	7.27602e-42 (rank : 74)	NC score	0.669649 (rank : 65)
Query Neighborhood Hits	485	Target Neighborhood Hits	431	Shared Neighborhood Hits	327
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

PTPRR_HUMAN
θ value	7.27602e-42 (rank : 75)	NC score	0.670401 (rank : 62)
Query Neighborhood Hits	485	Target Neighborhood Hits	77	Shared Neighborhood Hits	67
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

L1CAM_HUMAN
θ value	9.50281e-42 (rank : 76)	NC score	0.701570 (rank : 35)
Query Neighborhood Hits	485	Target Neighborhood Hits	457	Shared Neighborhood Hits	343
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PTN12_HUMAN
θ value	9.50281e-42 (rank : 77)	NC score	0.670304 (rank : 63)
Query Neighborhood Hits	485	Target Neighborhood Hits	102	Shared Neighborhood Hits	72
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN14_HUMAN
θ value	1.2411e-41 (rank : 78)	NC score	0.567218 (rank : 110)
Query Neighborhood Hits	485	Target Neighborhood Hits	163	Shared Neighborhood Hits	74
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN22_MOUSE
θ value	1.2411e-41 (rank : 79)	NC score	0.664930 (rank : 73)
Query Neighborhood Hits	485	Target Neighborhood Hits	179	Shared Neighborhood Hits	69
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

CNTN1_MOUSE
θ value	1.62093e-41 (rank : 80)	NC score	0.670745 (rank : 61)
Query Neighborhood Hits	485	Target Neighborhood Hits	422	Shared Neighborhood Hits	325
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

PTPRR_MOUSE
θ value	1.62093e-41 (rank : 81)	NC score	0.670167 (rank : 64)
Query Neighborhood Hits	485	Target Neighborhood Hits	84	Shared Neighborhood Hits	70
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

ROBO3_HUMAN
θ value	3.61106e-41 (rank : 82)	NC score	0.664881 (rank : 74)
Query Neighborhood Hits	485	Target Neighborhood Hits	570	Shared Neighborhood Hits	337
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

PTN14_MOUSE
θ value	6.15952e-41 (rank : 83)	NC score	0.563017 (rank : 114)
Query Neighborhood Hits	485	Target Neighborhood Hits	142	Shared Neighborhood Hits	70
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN12_MOUSE
θ value	2.34062e-40 (rank : 84)	NC score	0.669407 (rank : 66)
Query Neighborhood Hits	485	Target Neighborhood Hits	123	Shared Neighborhood Hits	71
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

TITIN_HUMAN
θ value	3.05695e-40 (rank : 85)	NC score	0.419731 (rank : 177)
Query Neighborhood Hits	485	Target Neighborhood Hits	2923	Shared Neighborhood Hits	400
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CNTN3_MOUSE
θ value	5.21438e-40 (rank : 86)	NC score	0.676269 (rank : 48)
Query Neighborhood Hits	485	Target Neighborhood Hits	447	Shared Neighborhood Hits	343
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

PTN18_HUMAN
θ value	1.51715e-39 (rank : 87)	NC score	0.673488 (rank : 54)
Query Neighborhood Hits	485	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

ROBO3_MOUSE
θ value	7.52953e-39 (rank : 88)	NC score	0.665879 (rank : 71)
Query Neighborhood Hits	485	Target Neighborhood Hits	524	Shared Neighborhood Hits	333
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

L1CAM_MOUSE
θ value	9.83387e-39 (rank : 89)	NC score	0.697104 (rank : 36)
Query Neighborhood Hits	485	Target Neighborhood Hits	457	Shared Neighborhood Hits	344
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PTN18_MOUSE
θ value	8.32485e-38 (rank : 90)	NC score	0.673176 (rank : 55)
Query Neighborhood Hits	485	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

CHL1_HUMAN
θ value	1.85459e-37 (rank : 91)	NC score	0.672183 (rank : 58)
Query Neighborhood Hits	485	Target Neighborhood Hits	413	Shared Neighborhood Hits	320
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

PUNC_HUMAN
θ value	1.85459e-37 (rank : 92)	NC score	0.679769 (rank : 43)
Query Neighborhood Hits	485	Target Neighborhood Hits	449	Shared Neighborhood Hits	318
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
θ value	2.42216e-37 (rank : 93)	NC score	0.670763 (rank : 60)
Query Neighborhood Hits	485	Target Neighborhood Hits	501	Shared Neighborhood Hits	315
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

USH2A_HUMAN
θ value	1.01765e-35 (rank : 94)	NC score	0.405558 (rank : 193)
Query Neighborhood Hits	485	Target Neighborhood Hits	600	Shared Neighborhood Hits	195
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

FINC_HUMAN
θ value	5.584e-34 (rank : 95)	NC score	0.560455 (rank : 115)
Query Neighborhood Hits	485	Target Neighborhood Hits	302	Shared Neighborhood Hits	192
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

CNTN4_MOUSE
θ value	1.37539e-32 (rank : 96)	NC score	0.661817 (rank : 78)
Query Neighborhood Hits	485	Target Neighborhood Hits	445	Shared Neighborhood Hits	327
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

FINC_MOUSE
θ value	2.34606e-32 (rank : 97)	NC score	0.564323 (rank : 113)
Query Neighborhood Hits	485	Target Neighborhood Hits	309	Shared Neighborhood Hits	181
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

NFASC_MOUSE
θ value	3.06405e-32 (rank : 98)	NC score	0.676029 (rank : 53)
Query Neighborhood Hits	485	Target Neighborhood Hits	475	Shared Neighborhood Hits	336
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

CNTN3_HUMAN
θ value	1.52067e-31 (rank : 99)	NC score	0.678381 (rank : 44)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	345
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN4_HUMAN
θ value	1.52067e-31 (rank : 100)	NC score	0.662197 (rank : 77)
Query Neighborhood Hits	485	Target Neighborhood Hits	449	Shared Neighborhood Hits	329
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

FNDC3_HUMAN
θ value	5.77852e-31 (rank : 101)	NC score	0.633554 (rank : 88)
Query Neighborhood Hits	485	Target Neighborhood Hits	196	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
θ value	1.6813e-30 (rank : 102)	NC score	0.629643 (rank : 89)
Query Neighborhood Hits	485	Target Neighborhood Hits	207	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

TENN_MOUSE
θ value	4.89182e-30 (rank : 103)	NC score	0.374107 (rank : 208)
Query Neighborhood Hits	485	Target Neighborhood Hits	484	Shared Neighborhood Hits	160
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

CHL1_MOUSE
θ value	2.42779e-29 (rank : 104)	NC score	0.660035 (rank : 79)
Query Neighborhood Hits	485	Target Neighborhood Hits	402	Shared Neighborhood Hits	316
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

COCA1_HUMAN
θ value	3.17079e-29 (rank : 105)	NC score	0.423023 (rank : 174)
Query Neighborhood Hits	485	Target Neighborhood Hits	458	Shared Neighborhood Hits	169
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

PTN23_HUMAN
θ value	7.06379e-29 (rank : 106)	NC score	0.571106 (rank : 109)
Query Neighborhood Hits	485	Target Neighborhood Hits	646	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	1.2049e-28 (rank : 107)	NC score	0.572219 (rank : 108)
Query Neighborhood Hits	485	Target Neighborhood Hits	726	Shared Neighborhood Hits	79
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

USH2A_MOUSE
θ value	4.57862e-28 (rank : 108)	NC score	0.392195 (rank : 198)
Query Neighborhood Hits	485	Target Neighborhood Hits	626	Shared Neighborhood Hits	185
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

TENR_HUMAN
θ value	1.02001e-27 (rank : 109)	NC score	0.359835 (rank : 223)
Query Neighborhood Hits	485	Target Neighborhood Hits	526	Shared Neighborhood Hits	168
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

TENR_MOUSE
θ value	1.02001e-27 (rank : 110)	NC score	0.351393 (rank : 225)
Query Neighborhood Hits	485	Target Neighborhood Hits	531	Shared Neighborhood Hits	164
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

CO7A1_HUMAN
θ value	1.33217e-27 (rank : 111)	NC score	0.309424 (rank : 238)
Query Neighborhood Hits	485	Target Neighborhood Hits	807	Shared Neighborhood Hits	164
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

COCA1_MOUSE
θ value	1.33217e-27 (rank : 112)	NC score	0.435624 (rank : 166)
Query Neighborhood Hits	485	Target Neighborhood Hits	467	Shared Neighborhood Hits	178
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

TENN_HUMAN
θ value	1.92365e-26 (rank : 113)	NC score	0.339630 (rank : 231)
Query Neighborhood Hits	485	Target Neighborhood Hits	453	Shared Neighborhood Hits	143
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

COEA1_MOUSE
θ value	6.18819e-25 (rank : 114)	NC score	0.369557 (rank : 212)
Query Neighborhood Hits	485	Target Neighborhood Hits	402	Shared Neighborhood Hits	116
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

MYOM1_HUMAN
θ value	4.01107e-24 (rank : 115)	NC score	0.616524 (rank : 97)
Query Neighborhood Hits	485	Target Neighborhood Hits	405	Shared Neighborhood Hits	300
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

HMCN1_HUMAN
θ value	1.5242e-23 (rank : 116)	NC score	0.419554 (rank : 178)
Query Neighborhood Hits	485	Target Neighborhood Hits	983	Shared Neighborhood Hits	299
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

TYRO3_HUMAN
θ value	1.6852e-22 (rank : 117)	NC score	0.292048 (rank : 248)
Query Neighborhood Hits	485	Target Neighborhood Hits	995	Shared Neighborhood Hits	267
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

COEA1_HUMAN
θ value	2.87452e-22 (rank : 118)	NC score	0.332658 (rank : 232)
Query Neighborhood Hits	485	Target Neighborhood Hits	427	Shared Neighborhood Hits	130
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

TYRO3_MOUSE
θ value	2.87452e-22 (rank : 119)	NC score	0.290701 (rank : 250)
Query Neighborhood Hits	485	Target Neighborhood Hits	1007	Shared Neighborhood Hits	272
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

MYLK_MOUSE
θ value	4.9032e-22 (rank : 120)	NC score	0.286336 (rank : 253)
Query Neighborhood Hits	485	Target Neighborhood Hits	1489	Shared Neighborhood Hits	323
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NCAM2_MOUSE
θ value	4.9032e-22 (rank : 121)	NC score	0.616908 (rank : 96)
Query Neighborhood Hits	485	Target Neighborhood Hits	472	Shared Neighborhood Hits	331
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

MUSK_MOUSE
θ value	6.40375e-22 (rank : 122)	NC score	0.348166 (rank : 226)
Query Neighborhood Hits	485	Target Neighborhood Hits	1057	Shared Neighborhood Hits	292
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NCA11_HUMAN
θ value	6.40375e-22 (rank : 123)	NC score	0.593642 (rank : 101)
Query Neighborhood Hits	485	Target Neighborhood Hits	443	Shared Neighborhood Hits	312
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

BOC_HUMAN
θ value	1.09232e-21 (rank : 124)	NC score	0.625902 (rank : 90)
Query Neighborhood Hits	485	Target Neighborhood Hits	543	Shared Neighborhood Hits	311
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCA11_MOUSE
θ value	1.09232e-21 (rank : 125)	NC score	0.579957 (rank : 106)
Query Neighborhood Hits	485	Target Neighborhood Hits	661	Shared Neighborhood Hits	313
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

ITB4_HUMAN
θ value	1.42661e-21 (rank : 126)	NC score	0.378691 (rank : 203)
Query Neighborhood Hits	485	Target Neighborhood Hits	458	Shared Neighborhood Hits	167
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

MUSK_HUMAN
θ value	1.86321e-21 (rank : 127)	NC score	0.347583 (rank : 227)
Query Neighborhood Hits	485	Target Neighborhood Hits	1074	Shared Neighborhood Hits	294
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MERTK_HUMAN
θ value	7.0802e-21 (rank : 128)	NC score	0.265786 (rank : 270)
Query Neighborhood Hits	485	Target Neighborhood Hits	988	Shared Neighborhood Hits	252
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

NCA12_MOUSE
θ value	1.2077e-20 (rank : 129)	NC score	0.585801 (rank : 103)
Query Neighborhood Hits	485	Target Neighborhood Hits	399	Shared Neighborhood Hits	295
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

BOC_MOUSE
θ value	5.99374e-20 (rank : 130)	NC score	0.618052 (rank : 95)
Query Neighborhood Hits	485	Target Neighborhood Hits	433	Shared Neighborhood Hits	302
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCAM2_HUMAN
θ value	5.99374e-20 (rank : 131)	NC score	0.603676 (rank : 100)
Query Neighborhood Hits	485	Target Neighborhood Hits	441	Shared Neighborhood Hits	325
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

OBSCN_HUMAN
θ value	5.99374e-20 (rank : 132)	NC score	0.291832 (rank : 249)
Query Neighborhood Hits	485	Target Neighborhood Hits	1931	Shared Neighborhood Hits	342
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

MYOM1_MOUSE
θ value	7.82807e-20 (rank : 133)	NC score	0.610716 (rank : 98)
Query Neighborhood Hits	485	Target Neighborhood Hits	415	Shared Neighborhood Hits	319
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

TENX_HUMAN
θ value	7.82807e-20 (rank : 134)	NC score	0.270547 (rank : 263)
Query Neighborhood Hits	485	Target Neighborhood Hits	789	Shared Neighborhood Hits	171
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

MYLK_HUMAN
θ value	1.02238e-19 (rank : 135)	NC score	0.288086 (rank : 251)
Query Neighborhood Hits	485	Target Neighborhood Hits	1328	Shared Neighborhood Hits	321
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

ROBO4_MOUSE
θ value	1.74391e-19 (rank : 136)	NC score	0.585467 (rank : 104)
Query Neighborhood Hits	485	Target Neighborhood Hits	358	Shared Neighborhood Hits	250
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

UFO_MOUSE
θ value	1.74391e-19 (rank : 137)	NC score	0.256516 (rank : 277)
Query Neighborhood Hits	485	Target Neighborhood Hits	988	Shared Neighborhood Hits	254
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

NCA12_HUMAN
θ value	5.07402e-19 (rank : 138)	NC score	0.583523 (rank : 105)
Query Neighborhood Hits	485	Target Neighborhood Hits	437	Shared Neighborhood Hits	307
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

LRIG1_HUMAN
θ value	2.5182e-18 (rank : 139)	NC score	0.413496 (rank : 185)
Query Neighborhood Hits	485	Target Neighborhood Hits	654	Shared Neighborhood Hits	267
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MERTK_MOUSE
θ value	2.5182e-18 (rank : 140)	NC score	0.259078 (rank : 275)
Query Neighborhood Hits	485	Target Neighborhood Hits	974	Shared Neighborhood Hits	244
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

LRIG3_HUMAN
θ value	3.28887e-18 (rank : 141)	NC score	0.395981 (rank : 197)
Query Neighborhood Hits	485	Target Neighborhood Hits	601	Shared Neighborhood Hits	269
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

TENA_HUMAN
θ value	4.29542e-18 (rank : 142)	NC score	0.284677 (rank : 254)
Query Neighborhood Hits	485	Target Neighborhood Hits	631	Shared Neighborhood Hits	162
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

LRIG3_MOUSE
θ value	5.60996e-18 (rank : 143)	NC score	0.399509 (rank : 194)
Query Neighborhood Hits	485	Target Neighborhood Hits	611	Shared Neighborhood Hits	270
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

CDON_MOUSE
θ value	7.32683e-18 (rank : 144)	NC score	0.621585 (rank : 94)
Query Neighborhood Hits	485	Target Neighborhood Hits	410	Shared Neighborhood Hits	304
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_HUMAN
θ value	1.24977e-17 (rank : 145)	NC score	0.624111 (rank : 91)
Query Neighborhood Hits	485	Target Neighborhood Hits	412	Shared Neighborhood Hits	305
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

PGBM_MOUSE
θ value	1.24977e-17 (rank : 146)	NC score	0.414945 (rank : 181)
Query Neighborhood Hits	485	Target Neighborhood Hits	1073	Shared Neighborhood Hits	297
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

LRIG1_MOUSE
θ value	3.63628e-17 (rank : 147)	NC score	0.407341 (rank : 191)
Query Neighborhood Hits	485	Target Neighborhood Hits	627	Shared Neighborhood Hits	267
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

SPEG_MOUSE
θ value	3.63628e-17 (rank : 148)	NC score	0.277612 (rank : 258)
Query Neighborhood Hits	485	Target Neighborhood Hits	1959	Shared Neighborhood Hits	314
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PGBM_HUMAN
θ value	4.74913e-17 (rank : 149)	NC score	0.421832 (rank : 175)
Query Neighborhood Hits	485	Target Neighborhood Hits	1113	Shared Neighborhood Hits	304
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

TENA_MOUSE
θ value	6.20254e-17 (rank : 150)	NC score	0.268692 (rank : 266)
Query Neighborhood Hits	485	Target Neighborhood Hits	596	Shared Neighborhood Hits	150
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

OBSL1_HUMAN
θ value	8.10077e-17 (rank : 151)	NC score	0.573138 (rank : 107)
Query Neighborhood Hits	485	Target Neighborhood Hits	354	Shared Neighborhood Hits	251
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

FGRL1_HUMAN
θ value	1.80466e-16 (rank : 152)	NC score	0.565726 (rank : 111)
Query Neighborhood Hits	485	Target Neighborhood Hits	335	Shared Neighborhood Hits	249
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

MYOM2_HUMAN
θ value	5.25075e-16 (rank : 153)	NC score	0.608944 (rank : 99)
Query Neighborhood Hits	485	Target Neighborhood Hits	341	Shared Neighborhood Hits	291
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

LRIG2_HUMAN
θ value	8.95645e-16 (rank : 154)	NC score	0.414155 (rank : 183)
Query Neighborhood Hits	485	Target Neighborhood Hits	595	Shared Neighborhood Hits	265
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

ROBO4_HUMAN
θ value	8.95645e-16 (rank : 155)	NC score	0.588710 (rank : 102)
Query Neighborhood Hits	485	Target Neighborhood Hits	364	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

SPEG_HUMAN
θ value	8.95645e-16 (rank : 156)	NC score	0.275871 (rank : 260)
Query Neighborhood Hits	485	Target Neighborhood Hits	1762	Shared Neighborhood Hits	310
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

UFO_HUMAN
θ value	1.16975e-15 (rank : 157)	NC score	0.253300 (rank : 279)
Query Neighborhood Hits	485	Target Neighborhood Hits	981	Shared Neighborhood Hits	248
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

FGRL1_MOUSE
θ value	1.99529e-15 (rank : 158)	NC score	0.565211 (rank : 112)
Query Neighborhood Hits	485	Target Neighborhood Hits	325	Shared Neighborhood Hits	252
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

TIE2_HUMAN
θ value	2.60593e-15 (rank : 159)	NC score	0.226116 (rank : 314)
Query Neighborhood Hits	485	Target Neighborhood Hits	1192	Shared Neighborhood Hits	197
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

LRIG2_MOUSE
θ value	3.40345e-15 (rank : 160)	NC score	0.412642 (rank : 186)
Query Neighborhood Hits	485	Target Neighborhood Hits	586	Shared Neighborhood Hits	267
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

IL6RB_HUMAN
θ value	5.8054e-15 (rank : 161)	NC score	0.411910 (rank : 187)
Query Neighborhood Hits	485	Target Neighborhood Hits	181	Shared Neighborhood Hits	137
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

TIE2_MOUSE
θ value	5.8054e-15 (rank : 162)	NC score	0.228773 (rank : 310)
Query Neighborhood Hits	485	Target Neighborhood Hits	1204	Shared Neighborhood Hits	197
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

EPHA4_MOUSE
θ value	1.68911e-14 (rank : 163)	NC score	0.221852 (rank : 325)
Query Neighborhood Hits	485	Target Neighborhood Hits	982	Shared Neighborhood Hits	187
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

COKA1_HUMAN
θ value	3.76295e-14 (rank : 164)	NC score	0.313138 (rank : 236)
Query Neighborhood Hits	485	Target Neighborhood Hits	403	Shared Neighborhood Hits	121
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

EPHA4_HUMAN
θ value	3.76295e-14 (rank : 165)	NC score	0.219656 (rank : 334)
Query Neighborhood Hits	485	Target Neighborhood Hits	975	Shared Neighborhood Hits	184
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

PTK7_HUMAN
θ value	4.91457e-14 (rank : 166)	NC score	0.363598 (rank : 218)
Query Neighborhood Hits	485	Target Neighborhood Hits	1103	Shared Neighborhood Hits	297
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

DUET_HUMAN
θ value	8.38298e-14 (rank : 167)	NC score	0.210334 (rank : 354)
Query Neighborhood Hits	485	Target Neighborhood Hits	1220	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

MYPC2_MOUSE
θ value	8.38298e-14 (rank : 168)	NC score	0.523279 (rank : 128)
Query Neighborhood Hits	485	Target Neighborhood Hits	297	Shared Neighborhood Hits	255
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPN_HUMAN
θ value	1.2105e-12 (rank : 169)	NC score	0.557488 (rank : 118)
Query Neighborhood Hits	485	Target Neighborhood Hits	418	Shared Neighborhood Hits	255
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

VGFR2_HUMAN
θ value	2.69671e-12 (rank : 170)	NC score	0.297182 (rank : 244)
Query Neighborhood Hits	485	Target Neighborhood Hits	1103	Shared Neighborhood Hits	289
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

EPHA3_MOUSE
θ value	3.52202e-12 (rank : 171)	NC score	0.222702 (rank : 322)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	197
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA8_MOUSE
θ value	6.00763e-12 (rank : 172)	NC score	0.224387 (rank : 319)
Query Neighborhood Hits	485	Target Neighborhood Hits	969	Shared Neighborhood Hits	195
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

IL6RB_MOUSE
θ value	6.00763e-12 (rank : 173)	NC score	0.367875 (rank : 214)
Query Neighborhood Hits	485	Target Neighborhood Hits	168	Shared Neighborhood Hits	132
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

MAMC1_MOUSE
θ value	1.33837e-11 (rank : 174)	NC score	0.551045 (rank : 121)
Query Neighborhood Hits	485	Target Neighborhood Hits	357	Shared Neighborhood Hits	251
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

EPHA7_HUMAN
θ value	1.74796e-11 (rank : 175)	NC score	0.228530 (rank : 312)
Query Neighborhood Hits	485	Target Neighborhood Hits	1053	Shared Neighborhood Hits	192
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA3_HUMAN
θ value	2.28291e-11 (rank : 176)	NC score	0.217700 (rank : 338)
Query Neighborhood Hits	485	Target Neighborhood Hits	1005	Shared Neighborhood Hits	198
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

LIFR_HUMAN
θ value	2.98157e-11 (rank : 177)	NC score	0.363358 (rank : 219)
Query Neighborhood Hits	485	Target Neighborhood Hits	130	Shared Neighborhood Hits	103
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

MYPC2_HUMAN
θ value	2.98157e-11 (rank : 178)	NC score	0.517748 (rank : 130)
Query Neighborhood Hits	485	Target Neighborhood Hits	316	Shared Neighborhood Hits	269
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

EPHA7_MOUSE
θ value	6.64225e-11 (rank : 179)	NC score	0.227561 (rank : 313)
Query Neighborhood Hits	485	Target Neighborhood Hits	1025	Shared Neighborhood Hits	189
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB1_HUMAN
θ value	6.64225e-11 (rank : 180)	NC score	0.202495 (rank : 366)
Query Neighborhood Hits	485	Target Neighborhood Hits	988	Shared Neighborhood Hits	177
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

MAMC1_HUMAN
θ value	6.64225e-11 (rank : 181)	NC score	0.550400 (rank : 122)
Query Neighborhood Hits	485	Target Neighborhood Hits	357	Shared Neighborhood Hits	249
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYPN_MOUSE
θ value	1.47974e-10 (rank : 182)	NC score	0.547343 (rank : 123)
Query Neighborhood Hits	485	Target Neighborhood Hits	421	Shared Neighborhood Hits	249
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

EPHA8_HUMAN
θ value	1.9326e-10 (rank : 183)	NC score	0.222029 (rank : 323)
Query Neighborhood Hits	485	Target Neighborhood Hits	956	Shared Neighborhood Hits	193
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

FGFR2_HUMAN
θ value	2.52405e-10 (rank : 184)	NC score	0.260022 (rank : 274)
Query Neighborhood Hits	485	Target Neighborhood Hits	1062	Shared Neighborhood Hits	267
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

MAG_HUMAN
θ value	4.30538e-10 (rank : 185)	NC score	0.477772 (rank : 145)
Query Neighborhood Hits	485	Target Neighborhood Hits	278	Shared Neighborhood Hits	226
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_MOUSE
θ value	4.30538e-10 (rank : 186)	NC score	0.478070 (rank : 144)
Query Neighborhood Hits	485	Target Neighborhood Hits	271	Shared Neighborhood Hits	227
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MYPC1_HUMAN
θ value	4.30538e-10 (rank : 187)	NC score	0.508591 (rank : 134)
Query Neighborhood Hits	485	Target Neighborhood Hits	303	Shared Neighborhood Hits	264
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

MYPC3_HUMAN
θ value	7.34386e-10 (rank : 188)	NC score	0.511769 (rank : 133)
Query Neighborhood Hits	485	Target Neighborhood Hits	318	Shared Neighborhood Hits	266
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

FGFR4_HUMAN
θ value	1.25267e-09 (rank : 189)	NC score	0.271708 (rank : 262)
Query Neighborhood Hits	485	Target Neighborhood Hits	1037	Shared Neighborhood Hits	277
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

I12R2_HUMAN
θ value	1.25267e-09 (rank : 190)	NC score	0.345361 (rank : 228)
Query Neighborhood Hits	485	Target Neighborhood Hits	163	Shared Neighborhood Hits	118
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

LIFR_MOUSE
θ value	1.25267e-09 (rank : 191)	NC score	0.363170 (rank : 220)
Query Neighborhood Hits	485	Target Neighborhood Hits	127	Shared Neighborhood Hits	100
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

FGFR4_MOUSE
θ value	1.63604e-09 (rank : 192)	NC score	0.277436 (rank : 259)
Query Neighborhood Hits	485	Target Neighborhood Hits	1026	Shared Neighborhood Hits	276
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

LSAMP_HUMAN
θ value	1.63604e-09 (rank : 193)	NC score	0.514494 (rank : 132)
Query Neighborhood Hits	485	Target Neighborhood Hits	347	Shared Neighborhood Hits	252
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYOTI_MOUSE
θ value	2.13673e-09 (rank : 194)	NC score	0.557792 (rank : 117)
Query Neighborhood Hits	485	Target Neighborhood Hits	297	Shared Neighborhood Hits	236
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPC3_MOUSE
θ value	2.13673e-09 (rank : 195)	NC score	0.505125 (rank : 137)
Query Neighborhood Hits	485	Target Neighborhood Hits	310	Shared Neighborhood Hits	263
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

VGFR2_MOUSE
θ value	2.13673e-09 (rank : 196)	NC score	0.292261 (rank : 247)
Query Neighborhood Hits	485	Target Neighborhood Hits	1089	Shared Neighborhood Hits	286
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

EPHA5_HUMAN
θ value	2.79066e-09 (rank : 197)	NC score	0.213252 (rank : 348)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	196
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

LSAMP_MOUSE
θ value	3.64472e-09 (rank : 198)	NC score	0.515564 (rank : 131)
Query Neighborhood Hits	485	Target Neighborhood Hits	344	Shared Neighborhood Hits	251
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

SORL_HUMAN
θ value	4.76016e-09 (rank : 199)	NC score	0.224942 (rank : 316)
Query Neighborhood Hits	485	Target Neighborhood Hits	440	Shared Neighborhood Hits	137
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
θ value	8.11959e-09 (rank : 200)	NC score	0.217494 (rank : 339)
Query Neighborhood Hits	485	Target Neighborhood Hits	439	Shared Neighborhood Hits	133
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

MYOTI_HUMAN
θ value	1.06045e-08 (rank : 201)	NC score	0.556341 (rank : 120)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

EPHA1_HUMAN
θ value	1.38499e-08 (rank : 202)	NC score	0.166096 (rank : 412)
Query Neighborhood Hits	485	Target Neighborhood Hits	997	Shared Neighborhood Hits	140
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

FGFR2_MOUSE
θ value	1.38499e-08 (rank : 203)	NC score	0.251500 (rank : 281)
Query Neighborhood Hits	485	Target Neighborhood Hits	1062	Shared Neighborhood Hits	263
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR1_HUMAN
θ value	1.80886e-08 (rank : 204)	NC score	0.264790 (rank : 271)
Query Neighborhood Hits	485	Target Neighborhood Hits	1069	Shared Neighborhood Hits	275
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	1.80886e-08 (rank : 205)	NC score	0.264468 (rank : 272)
Query Neighborhood Hits	485	Target Neighborhood Hits	1068	Shared Neighborhood Hits	274
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

I12R2_MOUSE
θ value	2.36244e-08 (rank : 206)	NC score	0.344004 (rank : 229)
Query Neighborhood Hits	485	Target Neighborhood Hits	143	Shared Neighborhood Hits	119
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

MALT1_HUMAN
θ value	2.36244e-08 (rank : 207)	NC score	0.489041 (rank : 143)
Query Neighborhood Hits	485	Target Neighborhood Hits	236	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

NEGR1_HUMAN
θ value	2.36244e-08 (rank : 208)	NC score	0.505572 (rank : 135)
Query Neighborhood Hits	485	Target Neighborhood Hits	346	Shared Neighborhood Hits	245
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

EPHB3_MOUSE
θ value	3.08544e-08 (rank : 209)	NC score	0.218959 (rank : 335)
Query Neighborhood Hits	485	Target Neighborhood Hits	996	Shared Neighborhood Hits	189
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

MUC18_HUMAN
θ value	3.08544e-08 (rank : 210)	NC score	0.441717 (rank : 160)
Query Neighborhood Hits	485	Target Neighborhood Hits	275	Shared Neighborhood Hits	199
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

NPHN_MOUSE
θ value	3.08544e-08 (rank : 211)	NC score	0.525712 (rank : 127)
Query Neighborhood Hits	485	Target Neighborhood Hits	370	Shared Neighborhood Hits	279
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

EPHB6_MOUSE
θ value	4.0297e-08 (rank : 212)	NC score	0.234520 (rank : 300)
Query Neighborhood Hits	485	Target Neighborhood Hits	906	Shared Neighborhood Hits	176
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

JAM3_HUMAN
θ value	4.0297e-08 (rank : 213)	NC score	0.445878 (rank : 157)
Query Neighborhood Hits	485	Target Neighborhood Hits	271	Shared Neighborhood Hits	210
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

NTRI_MOUSE
θ value	4.0297e-08 (rank : 214)	NC score	0.501133 (rank : 140)
Query Neighborhood Hits	485	Target Neighborhood Hits	342	Shared Neighborhood Hits	254
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

TIE1_HUMAN
θ value	4.0297e-08 (rank : 215)	NC score	0.232235 (rank : 301)
Query Neighborhood Hits	485	Target Neighborhood Hits	1241	Shared Neighborhood Hits	215
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	5.26297e-08 (rank : 216)	NC score	0.239694 (rank : 294)
Query Neighborhood Hits	485	Target Neighborhood Hits	912	Shared Neighborhood Hits	184
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

FGFR3_MOUSE
θ value	5.26297e-08 (rank : 217)	NC score	0.268709 (rank : 265)
Query Neighborhood Hits	485	Target Neighborhood Hits	1059	Shared Neighborhood Hits	273
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FSTL5_MOUSE
θ value	5.26297e-08 (rank : 218)	NC score	0.460873 (rank : 150)
Query Neighborhood Hits	485	Target Neighborhood Hits	355	Shared Neighborhood Hits	235
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

FGFR3_HUMAN
θ value	6.87365e-08 (rank : 219)	NC score	0.262211 (rank : 273)
Query Neighborhood Hits	485	Target Neighborhood Hits	1042	Shared Neighborhood Hits	270
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

CI094_HUMAN
θ value	8.97725e-08 (rank : 220)	NC score	0.408405 (rank : 190)
Query Neighborhood Hits	485	Target Neighborhood Hits	310	Shared Neighborhood Hits	218
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

EPHB3_HUMAN
θ value	8.97725e-08 (rank : 221)	NC score	0.216995 (rank : 342)
Query Neighborhood Hits	485	Target Neighborhood Hits	996	Shared Neighborhood Hits	187
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

KIRR2_HUMAN
θ value	8.97725e-08 (rank : 222)	NC score	0.456159 (rank : 153)
Query Neighborhood Hits	485	Target Neighborhood Hits	321	Shared Neighborhood Hits	216
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

ATL3_HUMAN
θ value	1.17247e-07 (rank : 223)	NC score	0.314555 (rank : 234)
Query Neighborhood Hits	485	Target Neighborhood Hits	414	Shared Neighborhood Hits	235
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

NTRI_HUMAN
θ value	1.17247e-07 (rank : 224)	NC score	0.497920 (rank : 142)
Query Neighborhood Hits	485	Target Neighborhood Hits	344	Shared Neighborhood Hits	255
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

RIMB2_MOUSE
θ value	1.17247e-07 (rank : 225)	NC score	0.174049 (rank : 401)
Query Neighborhood Hits	485	Target Neighborhood Hits	246	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ROS_HUMAN
θ value	1.17247e-07 (rank : 226)	NC score	0.208652 (rank : 356)
Query Neighborhood Hits	485	Target Neighborhood Hits	907	Shared Neighborhood Hits	189
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

EPHB2_HUMAN
θ value	1.99992e-07 (rank : 227)	NC score	0.204391 (rank : 363)
Query Neighborhood Hits	485	Target Neighborhood Hits	983	Shared Neighborhood Hits	176
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	1.99992e-07 (rank : 228)	NC score	0.204409 (rank : 362)
Query Neighborhood Hits	485	Target Neighborhood Hits	982	Shared Neighborhood Hits	176
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

FSTL4_HUMAN
θ value	1.99992e-07 (rank : 229)	NC score	0.462310 (rank : 149)
Query Neighborhood Hits	485	Target Neighborhood Hits	344	Shared Neighborhood Hits	241
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

NEGR1_MOUSE
θ value	1.99992e-07 (rank : 230)	NC score	0.503159 (rank : 139)
Query Neighborhood Hits	485	Target Neighborhood Hits	349	Shared Neighborhood Hits	247
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

RIMB2_HUMAN
θ value	2.61198e-07 (rank : 231)	NC score	0.180501 (rank : 391)
Query Neighborhood Hits	485	Target Neighborhood Hits	263	Shared Neighborhood Hits	62
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

FSTL4_MOUSE
θ value	4.45536e-07 (rank : 232)	NC score	0.457901 (rank : 152)
Query Neighborhood Hits	485	Target Neighborhood Hits	333	Shared Neighborhood Hits	236
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

VGFR1_MOUSE
θ value	4.45536e-07 (rank : 233)	NC score	0.302450 (rank : 241)
Query Neighborhood Hits	485	Target Neighborhood Hits	1118	Shared Neighborhood Hits	289
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

EPHB4_MOUSE
θ value	5.81887e-07 (rank : 234)	NC score	0.211152 (rank : 353)
Query Neighborhood Hits	485	Target Neighborhood Hits	1013	Shared Neighborhood Hits	184
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA6_HUMAN
θ value	7.59969e-07 (rank : 235)	NC score	0.201159 (rank : 371)
Query Neighborhood Hits	485	Target Neighborhood Hits	959	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

JAM1_HUMAN
θ value	7.59969e-07 (rank : 236)	NC score	0.438871 (rank : 161)
Query Neighborhood Hits	485	Target Neighborhood Hits	294	Shared Neighborhood Hits	212
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

MYBPH_HUMAN
θ value	7.59969e-07 (rank : 237)	NC score	0.433621 (rank : 167)
Query Neighborhood Hits	485	Target Neighborhood Hits	256	Shared Neighborhood Hits	220
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

OPCM_HUMAN
θ value	7.59969e-07 (rank : 238)	NC score	0.504404 (rank : 138)
Query Neighborhood Hits	485	Target Neighborhood Hits	332	Shared Neighborhood Hits	251
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

VGFR1_HUMAN
θ value	7.59969e-07 (rank : 239)	NC score	0.304449 (rank : 240)
Query Neighborhood Hits	485	Target Neighborhood Hits	1109	Shared Neighborhood Hits	290
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

EPHB4_HUMAN
θ value	9.92553e-07 (rank : 240)	NC score	0.206082 (rank : 357)
Query Neighborhood Hits	485	Target Neighborhood Hits	1056	Shared Neighborhood Hits	188
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

MDGA1_HUMAN
θ value	9.92553e-07 (rank : 241)	NC score	0.545764 (rank : 124)
Query Neighborhood Hits	485	Target Neighborhood Hits	358	Shared Neighborhood Hits	254
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

PGFRA_MOUSE
θ value	9.92553e-07 (rank : 242)	NC score	0.214705 (rank : 347)
Query Neighborhood Hits	485	Target Neighborhood Hits	975	Shared Neighborhood Hits	226
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

LRFN5_MOUSE
θ value	1.29631e-06 (rank : 243)	NC score	0.250666 (rank : 283)
Query Neighborhood Hits	485	Target Neighborhood Hits	472	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

NPHN_HUMAN
θ value	1.69304e-06 (rank : 244)	NC score	0.536342 (rank : 125)
Query Neighborhood Hits	485	Target Neighborhood Hits	362	Shared Neighborhood Hits	274
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

INSRR_HUMAN
θ value	2.88788e-06 (rank : 245)	NC score	0.177340 (rank : 395)
Query Neighborhood Hits	485	Target Neighborhood Hits	950	Shared Neighborhood Hits	141
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

LRFN4_MOUSE
θ value	2.88788e-06 (rank : 246)	NC score	0.274558 (rank : 261)
Query Neighborhood Hits	485	Target Neighborhood Hits	442	Shared Neighborhood Hits	202
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN5_HUMAN
θ value	2.88788e-06 (rank : 247)	NC score	0.245192 (rank : 290)
Query Neighborhood Hits	485	Target Neighborhood Hits	464	Shared Neighborhood Hits	204
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

MYBPH_MOUSE
θ value	2.88788e-06 (rank : 248)	NC score	0.444529 (rank : 158)
Query Neighborhood Hits	485	Target Neighborhood Hits	290	Shared Neighborhood Hits	226
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

FSTL5_HUMAN
θ value	3.77169e-06 (rank : 249)	NC score	0.463661 (rank : 148)
Query Neighborhood Hits	485	Target Neighborhood Hits	347	Shared Neighborhood Hits	239
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

LRFN4_HUMAN
θ value	3.77169e-06 (rank : 250)	NC score	0.279797 (rank : 257)
Query Neighborhood Hits	485	Target Neighborhood Hits	462	Shared Neighborhood Hits	211
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

CSF3R_HUMAN
θ value	4.92598e-06 (rank : 251)	NC score	0.302177 (rank : 242)
Query Neighborhood Hits	485	Target Neighborhood Hits	140	Shared Neighborhood Hits	109
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

EPHA2_HUMAN
θ value	4.92598e-06 (rank : 252)	NC score	0.197727 (rank : 373)
Query Neighborhood Hits	485	Target Neighborhood Hits	1021	Shared Neighborhood Hits	174
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ICAM5_MOUSE
θ value	4.92598e-06 (rank : 253)	NC score	0.438013 (rank : 162)
Query Neighborhood Hits	485	Target Neighborhood Hits	308	Shared Neighborhood Hits	219
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

JAM1_MOUSE
θ value	4.92598e-06 (rank : 254)	NC score	0.419010 (rank : 179)
Query Neighborhood Hits	485	Target Neighborhood Hits	287	Shared Neighborhood Hits	201
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

ROR2_MOUSE
θ value	4.92598e-06 (rank : 255)	NC score	0.238294 (rank : 295)
Query Neighborhood Hits	485	Target Neighborhood Hits	1000	Shared Neighborhood Hits	253
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

EPHA5_MOUSE
θ value	6.43352e-06 (rank : 256)	NC score	0.192158 (rank : 381)
Query Neighborhood Hits	485	Target Neighborhood Hits	950	Shared Neighborhood Hits	184
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

KALM_HUMAN
θ value	6.43352e-06 (rank : 257)	NC score	0.293184 (rank : 246)
Query Neighborhood Hits	485	Target Neighborhood Hits	114	Shared Neighborhood Hits	81
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

PGFRA_HUMAN
θ value	6.43352e-06 (rank : 258)	NC score	0.214965 (rank : 346)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	226
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ROR1_MOUSE
θ value	8.40245e-06 (rank : 259)	NC score	0.220258 (rank : 332)
Query Neighborhood Hits	485	Target Neighborhood Hits	1025	Shared Neighborhood Hits	252
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ICAM5_HUMAN
θ value	1.09739e-05 (rank : 260)	NC score	0.427120 (rank : 173)
Query Neighborhood Hits	485	Target Neighborhood Hits	276	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

JAM3_MOUSE
θ value	1.09739e-05 (rank : 261)	NC score	0.437413 (rank : 163)
Query Neighborhood Hits	485	Target Neighborhood Hits	286	Shared Neighborhood Hits	211
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

KAZD1_HUMAN
θ value	1.09739e-05 (rank : 262)	NC score	0.397265 (rank : 195)
Query Neighborhood Hits	485	Target Neighborhood Hits	248	Shared Neighborhood Hits	160
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

SIG10_HUMAN
θ value	1.43324e-05 (rank : 263)	NC score	0.374201 (rank : 207)
Query Neighborhood Hits	485	Target Neighborhood Hits	363	Shared Neighborhood Hits	212
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

CD22_MOUSE
θ value	1.87187e-05 (rank : 264)	NC score	0.430775 (rank : 169)
Query Neighborhood Hits	485	Target Neighborhood Hits	331	Shared Neighborhood Hits	204
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

ROR2_HUMAN
θ value	1.87187e-05 (rank : 265)	NC score	0.230388 (rank : 305)
Query Neighborhood Hits	485	Target Neighborhood Hits	1014	Shared Neighborhood Hits	250
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

VGFR3_HUMAN
θ value	1.87187e-05 (rank : 266)	NC score	0.251948 (rank : 280)
Query Neighborhood Hits	485	Target Neighborhood Hits	1037	Shared Neighborhood Hits	261
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

EPHA1_MOUSE
θ value	2.44474e-05 (rank : 267)	NC score	0.168678 (rank : 410)
Query Neighborhood Hits	485	Target Neighborhood Hits	958	Shared Neighborhood Hits	148
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

KIRR2_MOUSE
θ value	2.44474e-05 (rank : 268)	NC score	0.449714 (rank : 156)
Query Neighborhood Hits	485	Target Neighborhood Hits	326	Shared Neighborhood Hits	216
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

ROR1_HUMAN
θ value	2.44474e-05 (rank : 269)	NC score	0.220925 (rank : 326)
Query Neighborhood Hits	485	Target Neighborhood Hits	1018	Shared Neighborhood Hits	245
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

CSF3R_MOUSE
θ value	4.1701e-05 (rank : 270)	NC score	0.245284 (rank : 289)
Query Neighborhood Hits	485	Target Neighborhood Hits	104	Shared Neighborhood Hits	87
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

EPHA2_MOUSE
θ value	4.1701e-05 (rank : 271)	NC score	0.190764 (rank : 383)
Query Neighborhood Hits	485	Target Neighborhood Hits	1020	Shared Neighborhood Hits	168
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA6_MOUSE
θ value	4.1701e-05 (rank : 272)	NC score	0.192832 (rank : 379)
Query Neighborhood Hits	485	Target Neighborhood Hits	946	Shared Neighborhood Hits	156
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

TIE1_MOUSE
θ value	4.1701e-05 (rank : 273)	NC score	0.241071 (rank : 293)
Query Neighborhood Hits	485	Target Neighborhood Hits	1266	Shared Neighborhood Hits	229
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

VCAM1_MOUSE
θ value	4.1701e-05 (rank : 274)	NC score	0.475982 (rank : 146)
Query Neighborhood Hits	485	Target Neighborhood Hits	320	Shared Neighborhood Hits	228
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

I12R1_MOUSE
θ value	5.44631e-05 (rank : 275)	NC score	0.177285 (rank : 397)
Query Neighborhood Hits	485	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

JAM2_HUMAN
θ value	5.44631e-05 (rank : 276)	NC score	0.413823 (rank : 184)
Query Neighborhood Hits	485	Target Neighborhood Hits	304	Shared Neighborhood Hits	229
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

SIG11_HUMAN
θ value	5.44631e-05 (rank : 277)	NC score	0.381176 (rank : 201)
Query Neighborhood Hits	485	Target Neighborhood Hits	273	Shared Neighborhood Hits	213
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

I12R1_HUMAN
θ value	7.1131e-05 (rank : 278)	NC score	0.191716 (rank : 382)
Query Neighborhood Hits	485	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

KAZD1_MOUSE
θ value	7.1131e-05 (rank : 279)	NC score	0.416867 (rank : 180)
Query Neighborhood Hits	485	Target Neighborhood Hits	281	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

VCAM1_HUMAN
θ value	7.1131e-05 (rank : 280)	NC score	0.468490 (rank : 147)
Query Neighborhood Hits	485	Target Neighborhood Hits	352	Shared Neighborhood Hits	225
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

VGFR3_MOUSE
θ value	9.29e-05 (rank : 281)	NC score	0.250399 (rank : 284)
Query Neighborhood Hits	485	Target Neighborhood Hits	1056	Shared Neighborhood Hits	268
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

IBP7_HUMAN
θ value	0.000121331 (rank : 282)	NC score	0.371795 (rank : 210)
Query Neighborhood Hits	485	Target Neighborhood Hits	220	Shared Neighborhood Hits	163
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

MUC18_MOUSE
θ value	0.000121331 (rank : 283)	NC score	0.427648 (rank : 172)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	201
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

NRG2_MOUSE
θ value	0.000121331 (rank : 284)	NC score	0.367429 (rank : 215)
Query Neighborhood Hits	485	Target Neighborhood Hits	392	Shared Neighborhood Hits	222
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

TMIGD_HUMAN
θ value	0.000121331 (rank : 285)	NC score	0.458572 (rank : 151)
Query Neighborhood Hits	485	Target Neighborhood Hits	240	Shared Neighborhood Hits	201
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

IBP7_MOUSE
θ value	0.000158464 (rank : 286)	NC score	0.362195 (rank : 222)
Query Neighborhood Hits	485	Target Neighborhood Hits	230	Shared Neighborhood Hits	161
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

LRFN3_HUMAN
θ value	0.000158464 (rank : 287)	NC score	0.255099 (rank : 278)
Query Neighborhood Hits	485	Target Neighborhood Hits	444	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

NTRK2_HUMAN
θ value	0.000158464 (rank : 288)	NC score	0.220263 (rank : 330)
Query Neighborhood Hits	485	Target Neighborhood Hits	1081	Shared Neighborhood Hits	243
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

EPHAA_HUMAN
θ value	0.00020696 (rank : 289)	NC score	0.189168 (rank : 384)
Query Neighborhood Hits	485	Target Neighborhood Hits	960	Shared Neighborhood Hits	156
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

IGF1R_HUMAN
θ value	0.00020696 (rank : 290)	NC score	0.174683 (rank : 399)
Query Neighborhood Hits	485	Target Neighborhood Hits	977	Shared Neighborhood Hits	141
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	0.000270298 (rank : 291)	NC score	0.173536 (rank : 405)
Query Neighborhood Hits	485	Target Neighborhood Hits	973	Shared Neighborhood Hits	142
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LRFN2_MOUSE
θ value	0.000270298 (rank : 292)	NC score	0.267056 (rank : 267)
Query Neighborhood Hits	485	Target Neighborhood Hits	450	Shared Neighborhood Hits	208
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

NPTN_MOUSE
θ value	0.000270298 (rank : 293)	NC score	0.428392 (rank : 171)
Query Neighborhood Hits	485	Target Neighborhood Hits	216	Shared Neighborhood Hits	187
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

NRG2_HUMAN
θ value	0.000270298 (rank : 294)	NC score	0.372703 (rank : 209)
Query Neighborhood Hits	485	Target Neighborhood Hits	419	Shared Neighborhood Hits	221
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

TARSH_HUMAN
θ value	0.000270298 (rank : 295)	NC score	0.237392 (rank : 296)
Query Neighborhood Hits	485	Target Neighborhood Hits	768	Shared Neighborhood Hits	120
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

INSRR_MOUSE
θ value	0.00035302 (rank : 296)	NC score	0.173911 (rank : 402)
Query Neighborhood Hits	485	Target Neighborhood Hits	961	Shared Neighborhood Hits	141
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_MOUSE
θ value	0.00035302 (rank : 297)	NC score	0.172102 (rank : 407)
Query Neighborhood Hits	485	Target Neighborhood Hits	968	Shared Neighborhood Hits	141
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KIRR3_HUMAN
θ value	0.00035302 (rank : 298)	NC score	0.414534 (rank : 182)
Query Neighborhood Hits	485	Target Neighborhood Hits	302	Shared Neighborhood Hits	214
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

LRFN3_MOUSE
θ value	0.00035302 (rank : 299)	NC score	0.266276 (rank : 269)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	209
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

NTRK2_MOUSE
θ value	0.00035302 (rank : 300)	NC score	0.219752 (rank : 333)
Query Neighborhood Hits	485	Target Neighborhood Hits	1088	Shared Neighborhood Hits	246
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

TRIO_HUMAN
θ value	0.00035302 (rank : 301)	NC score	0.133814 (rank : 438)
Query Neighborhood Hits	485	Target Neighborhood Hits	1580	Shared Neighborhood Hits	254
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

RAGE_HUMAN
θ value	0.000461057 (rank : 302)	NC score	0.450329 (rank : 155)
Query Neighborhood Hits	485	Target Neighborhood Hits	269	Shared Neighborhood Hits	212
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

CEAM1_HUMAN
θ value	0.000602161 (rank : 303)	NC score	0.339913 (rank : 230)
Query Neighborhood Hits	485	Target Neighborhood Hits	348	Shared Neighborhood Hits	203
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

I13R1_MOUSE
θ value	0.000786445 (rank : 304)	NC score	0.051119 (rank : 798)
Query Neighborhood Hits	485	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	O09030, Q7TT27	Gene names	Il13ra1, Il13r, Il13ra
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (Interleukin-13-binding protein) (NR4) (CD213a1 antigen).

LRFN2_HUMAN
θ value	0.000786445 (rank : 305)	NC score	0.266646 (rank : 268)
Query Neighborhood Hits	485	Target Neighborhood Hits	450	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

TMIGD_MOUSE
θ value	0.000786445 (rank : 306)	NC score	0.444248 (rank : 159)
Query Neighborhood Hits	485	Target Neighborhood Hits	234	Shared Neighborhood Hits	205
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

RAGE_MOUSE
θ value	0.00102713 (rank : 307)	NC score	0.429453 (rank : 170)
Query Neighborhood Hits	485	Target Neighborhood Hits	295	Shared Neighborhood Hits	196
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

UNC5D_MOUSE
θ value	0.00102713 (rank : 308)	NC score	0.250164 (rank : 285)
Query Neighborhood Hits	485	Target Neighborhood Hits	268	Shared Neighborhood Hits	171
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

CD22_HUMAN
θ value	0.00134147 (rank : 309)	NC score	0.420303 (rank : 176)
Query Neighborhood Hits	485	Target Neighborhood Hits	365	Shared Neighborhood Hits	218
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

HCFC2_MOUSE
θ value	0.00134147 (rank : 310)	NC score	0.268788 (rank : 264)
Query Neighborhood Hits	485	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

JAM2_MOUSE
θ value	0.00134147 (rank : 311)	NC score	0.396117 (rank : 196)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

KIRR1_HUMAN
θ value	0.00134147 (rank : 312)	NC score	0.410493 (rank : 188)
Query Neighborhood Hits	485	Target Neighborhood Hits	401	Shared Neighborhood Hits	224
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

NPTN_HUMAN
θ value	0.00134147 (rank : 313)	NC score	0.436642 (rank : 164)
Query Neighborhood Hits	485	Target Neighborhood Hits	212	Shared Neighborhood Hits	190
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

TP4A3_HUMAN
θ value	0.00134147 (rank : 314)	NC score	0.118031 (rank : 462)
Query Neighborhood Hits	485	Target Neighborhood Hits	62	Shared Neighborhood Hits	37
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

SIGL5_MOUSE
θ value	0.00175202 (rank : 315)	NC score	0.299855 (rank : 243)
Query Neighborhood Hits	485	Target Neighborhood Hits	271	Shared Neighborhood Hits	200
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

UNC5D_HUMAN
θ value	0.00175202 (rank : 316)	NC score	0.245017 (rank : 292)
Query Neighborhood Hits	485	Target Neighborhood Hits	267	Shared Neighborhood Hits	169
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

TP4A3_MOUSE
θ value	0.00228821 (rank : 317)	NC score	0.110564 (rank : 488)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

CEAM6_HUMAN
θ value	0.00298849 (rank : 318)	NC score	0.296537 (rank : 245)
Query Neighborhood Hits	485	Target Neighborhood Hits	308	Shared Neighborhood Hits	204
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

KIRR3_MOUSE
θ value	0.00298849 (rank : 319)	NC score	0.409697 (rank : 189)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	210
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

IRPL1_MOUSE
θ value	0.00390308 (rank : 320)	NC score	0.229403 (rank : 309)
Query Neighborhood Hits	485	Target Neighborhood Hits	186	Shared Neighborhood Hits	146
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

KIRR1_MOUSE
θ value	0.00390308 (rank : 321)	NC score	0.406631 (rank : 192)
Query Neighborhood Hits	485	Target Neighborhood Hits	403	Shared Neighborhood Hits	222
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

TP4A1_HUMAN
θ value	0.00390308 (rank : 322)	NC score	0.128638 (rank : 443)
Query Neighborhood Hits	485	Target Neighborhood Hits	68	Shared Neighborhood Hits	47
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
θ value	0.00390308 (rank : 323)	NC score	0.128638 (rank : 444)
Query Neighborhood Hits	485	Target Neighborhood Hits	68	Shared Neighborhood Hits	47
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

INSR_HUMAN
θ value	0.00509761 (rank : 324)	NC score	0.167901 (rank : 411)
Query Neighborhood Hits	485	Target Neighborhood Hits	963	Shared Neighborhood Hits	137
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

UNC5B_HUMAN
θ value	0.00509761 (rank : 325)	NC score	0.197130 (rank : 374)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5B_MOUSE
θ value	0.00509761 (rank : 326)	NC score	0.193141 (rank : 378)
Query Neighborhood Hits	485	Target Neighborhood Hits	226	Shared Neighborhood Hits	128
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

ANKF1_HUMAN
θ value	0.00665767 (rank : 327)	NC score	0.154956 (rank : 424)
Query Neighborhood Hits	485	Target Neighborhood Hits	126	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

MFA3L_HUMAN
θ value	0.00665767 (rank : 328)	NC score	0.382523 (rank : 200)
Query Neighborhood Hits	485	Target Neighborhood Hits	230	Shared Neighborhood Hits	199
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

UNC5C_HUMAN
θ value	0.00665767 (rank : 329)	NC score	0.205109 (rank : 358)
Query Neighborhood Hits	485	Target Neighborhood Hits	226	Shared Neighborhood Hits	123
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	0.00665767 (rank : 330)	NC score	0.205051 (rank : 359)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	126
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

CEAM5_HUMAN
θ value	0.00869519 (rank : 331)	NC score	0.380532 (rank : 202)
Query Neighborhood Hits	485	Target Neighborhood Hits	343	Shared Neighborhood Hits	222
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

CILP2_HUMAN
θ value	0.00869519 (rank : 332)	NC score	0.283129 (rank : 256)
Query Neighborhood Hits	485	Target Neighborhood Hits	307	Shared Neighborhood Hits	181
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

MUC_HUMAN
θ value	0.00869519 (rank : 333)	NC score	0.036402 (rank : 830)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	31
SwissProt Accessions	P01871	Gene names	IGHM
Domain Architecture
Description	Ig mu chain C region.

LRRN3_HUMAN
θ value	0.0113563 (rank : 334)	NC score	0.224780 (rank : 317)
Query Neighborhood Hits	485	Target Neighborhood Hits	461	Shared Neighborhood Hits	210
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

MFA3L_MOUSE
θ value	0.0113563 (rank : 335)	NC score	0.330537 (rank : 233)
Query Neighborhood Hits	485	Target Neighborhood Hits	214	Shared Neighborhood Hits	183
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

BASI_HUMAN
θ value	0.0148317 (rank : 336)	NC score	0.388284 (rank : 199)
Query Neighborhood Hits	485	Target Neighborhood Hits	211	Shared Neighborhood Hits	180
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

HCFC2_HUMAN
θ value	0.0148317 (rank : 337)	NC score	0.178898 (rank : 393)
Query Neighborhood Hits	485	Target Neighborhood Hits	154	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

IRPL2_HUMAN
θ value	0.0148317 (rank : 338)	NC score	0.230773 (rank : 303)
Query Neighborhood Hits	485	Target Neighborhood Hits	194	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

IRPL2_MOUSE
θ value	0.0148317 (rank : 339)	NC score	0.228770 (rank : 311)
Query Neighborhood Hits	485	Target Neighborhood Hits	195	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

LRRN1_HUMAN
θ value	0.0148317 (rank : 340)	NC score	0.229492 (rank : 308)
Query Neighborhood Hits	485	Target Neighborhood Hits	518	Shared Neighborhood Hits	237
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

LRRN3_MOUSE
θ value	0.0148317 (rank : 341)	NC score	0.211415 (rank : 352)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	205
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

LU_HUMAN
θ value	0.0148317 (rank : 342)	NC score	0.455031 (rank : 154)
Query Neighborhood Hits	485	Target Neighborhood Hits	283	Shared Neighborhood Hits	215
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

NTRK3_HUMAN
θ value	0.0148317 (rank : 343)	NC score	0.218454 (rank : 337)
Query Neighborhood Hits	485	Target Neighborhood Hits	1115	Shared Neighborhood Hits	243
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

SN_HUMAN
θ value	0.0148317 (rank : 344)	NC score	0.431191 (rank : 168)
Query Neighborhood Hits	485	Target Neighborhood Hits	434	Shared Neighborhood Hits	245
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

TP4A2_HUMAN
θ value	0.0148317 (rank : 345)	NC score	0.108867 (rank : 502)
Query Neighborhood Hits	485	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
θ value	0.0148317 (rank : 346)	NC score	0.108867 (rank : 503)
Query Neighborhood Hits	485	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

HCFC1_MOUSE
θ value	0.0193708 (rank : 347)	NC score	0.115213 (rank : 472)
Query Neighborhood Hits	485	Target Neighborhood Hits	348	Shared Neighborhood Hits	67
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

IGS21_HUMAN
θ value	0.0193708 (rank : 348)	NC score	0.201469 (rank : 369)
Query Neighborhood Hits	485	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGS21_MOUSE
θ value	0.0193708 (rank : 349)	NC score	0.198413 (rank : 372)
Query Neighborhood Hits	485	Target Neighborhood Hits	118	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

LEPR_HUMAN
θ value	0.0193708 (rank : 350)	NC score	0.119856 (rank : 456)
Query Neighborhood Hits	485	Target Neighborhood Hits	112	Shared Neighborhood Hits	75
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

SIGL5_HUMAN
θ value	0.0193708 (rank : 351)	NC score	0.249897 (rank : 286)
Query Neighborhood Hits	485	Target Neighborhood Hits	246	Shared Neighborhood Hits	171
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

BASI_MOUSE
θ value	0.0252991 (rank : 352)	NC score	0.377816 (rank : 205)
Query Neighborhood Hits	485	Target Neighborhood Hits	238	Shared Neighborhood Hits	182
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

CSF1R_MOUSE
θ value	0.0252991 (rank : 353)	NC score	0.230735 (rank : 304)
Query Neighborhood Hits	485	Target Neighborhood Hits	983	Shared Neighborhood Hits	229
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

IRPL1_HUMAN
θ value	0.0252991 (rank : 354)	NC score	0.216008 (rank : 345)
Query Neighborhood Hits	485	Target Neighborhood Hits	196	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

CRLF1_HUMAN
θ value	0.0330416 (rank : 355)	NC score	0.208866 (rank : 355)
Query Neighborhood Hits	485	Target Neighborhood Hits	122	Shared Neighborhood Hits	94
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CRLF1_MOUSE
θ value	0.0431538 (rank : 356)	NC score	0.203105 (rank : 364)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

I11RA_MOUSE
θ value	0.0431538 (rank : 357)	NC score	0.115795 (rank : 470)
Query Neighborhood Hits	485	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

I11RB_MOUSE
θ value	0.0431538 (rank : 358)	NC score	0.128914 (rank : 442)
Query Neighborhood Hits	485	Target Neighborhood Hits	101	Shared Neighborhood Hits	71
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

LRC21_MOUSE
θ value	0.0431538 (rank : 359)	NC score	0.247537 (rank : 288)
Query Neighborhood Hits	485	Target Neighborhood Hits	462	Shared Neighborhood Hits	219
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

SN_MOUSE
θ value	0.0431538 (rank : 360)	NC score	0.435878 (rank : 165)
Query Neighborhood Hits	485	Target Neighborhood Hits	416	Shared Neighborhood Hits	248
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

FCRL2_HUMAN
θ value	0.0563607 (rank : 361)	NC score	0.363084 (rank : 221)
Query Neighborhood Hits	485	Target Neighborhood Hits	251	Shared Neighborhood Hits	174
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

CEAM1_MOUSE
θ value	0.0736092 (rank : 362)	NC score	0.371650 (rank : 211)
Query Neighborhood Hits	485	Target Neighborhood Hits	326	Shared Neighborhood Hits	220
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

LRRN1_MOUSE
θ value	0.0736092 (rank : 363)	NC score	0.220262 (rank : 331)
Query Neighborhood Hits	485	Target Neighborhood Hits	508	Shared Neighborhood Hits	231
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

PTEN_HUMAN
θ value	0.0736092 (rank : 364)	NC score	0.099644 (rank : 555)
Query Neighborhood Hits	485	Target Neighborhood Hits	72	Shared Neighborhood Hits	43
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	0.0736092 (rank : 365)	NC score	0.099642 (rank : 556)
Query Neighborhood Hits	485	Target Neighborhood Hits	73	Shared Neighborhood Hits	43
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

CILP1_HUMAN
θ value	0.0961366 (rank : 366)	NC score	0.220426 (rank : 329)
Query Neighborhood Hits	485	Target Neighborhood Hits	266	Shared Neighborhood Hits	164
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CSF1R_HUMAN
θ value	0.0961366 (rank : 367)	NC score	0.196019 (rank : 376)
Query Neighborhood Hits	485	Target Neighborhood Hits	943	Shared Neighborhood Hits	202
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

HCFC1_HUMAN
θ value	0.0961366 (rank : 368)	NC score	0.098188 (rank : 560)
Query Neighborhood Hits	485	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

KIT_MOUSE
θ value	0.0961366 (rank : 369)	NC score	0.205000 (rank : 360)
Query Neighborhood Hits	485	Target Neighborhood Hits	949	Shared Neighborhood Hits	210
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

DUS23_MOUSE
θ value	0.125558 (rank : 370)	NC score	0.225178 (rank : 315)
Query Neighborhood Hits	485	Target Neighborhood Hits	94	Shared Neighborhood Hits	62
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

VSIG2_MOUSE
θ value	0.125558 (rank : 371)	NC score	0.368019 (rank : 213)
Query Neighborhood Hits	485	Target Neighborhood Hits	316	Shared Neighborhood Hits	204
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

FCRL5_HUMAN
θ value	0.163984 (rank : 372)	NC score	0.365683 (rank : 216)
Query Neighborhood Hits	485	Target Neighborhood Hits	267	Shared Neighborhood Hits	191
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

HHLA2_HUMAN
θ value	0.163984 (rank : 373)	NC score	0.143996 (rank : 431)
Query Neighborhood Hits	485	Target Neighborhood Hits	140	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

I11RA_HUMAN
θ value	0.163984 (rank : 374)	NC score	0.116289 (rank : 469)
Query Neighborhood Hits	485	Target Neighborhood Hits	138	Shared Neighborhood Hits	73
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

IL1R1_MOUSE
θ value	0.163984 (rank : 375)	NC score	0.178063 (rank : 394)
Query Neighborhood Hits	485	Target Neighborhood Hits	142	Shared Neighborhood Hits	117
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

IL1R2_HUMAN
θ value	0.163984 (rank : 376)	NC score	0.258847 (rank : 276)
Query Neighborhood Hits	485	Target Neighborhood Hits	153	Shared Neighborhood Hits	124
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

IL1R2_MOUSE
θ value	0.163984 (rank : 377)	NC score	0.213162 (rank : 349)
Query Neighborhood Hits	485	Target Neighborhood Hits	125	Shared Neighborhood Hits	97
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

LRC24_HUMAN
θ value	0.163984 (rank : 378)	NC score	0.187340 (rank : 387)
Query Neighborhood Hits	485	Target Neighborhood Hits	404	Shared Neighborhood Hits	180
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

LRC24_MOUSE
θ value	0.163984 (rank : 379)	NC score	0.168858 (rank : 409)
Query Neighborhood Hits	485	Target Neighborhood Hits	387	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

MUCB_HUMAN
θ value	0.163984 (rank : 380)	NC score	0.032777 (rank : 836)
Query Neighborhood Hits	485	Target Neighborhood Hits	233	Shared Neighborhood Hits	33
SwissProt Accessions	P04220	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu heavy chain disease protein (BOT).

TRIM1_MOUSE
θ value	0.163984 (rank : 381)	NC score	0.033995 (rank : 834)
Query Neighborhood Hits	485	Target Neighborhood Hits	361	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

GGA1_HUMAN
θ value	0.21417 (rank : 382)	NC score	0.014909 (rank : 858)
Query Neighborhood Hits	485	Target Neighborhood Hits	169	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

DUS23_HUMAN
θ value	0.279714 (rank : 383)	NC score	0.211867 (rank : 351)
Query Neighborhood Hits	485	Target Neighborhood Hits	98	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

I27RA_HUMAN
θ value	0.279714 (rank : 384)	NC score	0.152296 (rank : 426)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

IL27B_HUMAN
θ value	0.279714 (rank : 385)	NC score	0.147908 (rank : 427)
Query Neighborhood Hits	485	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

RIMB1_HUMAN
θ value	0.279714 (rank : 386)	NC score	0.033912 (rank : 835)
Query Neighborhood Hits	485	Target Neighborhood Hits	1479	Shared Neighborhood Hits	46
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TRI18_HUMAN
θ value	0.279714 (rank : 387)	NC score	0.034582 (rank : 832)
Query Neighborhood Hits	485	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

CT075_HUMAN
θ value	0.365318 (rank : 388)	NC score	0.153897 (rank : 425)
Query Neighborhood Hits	485	Target Neighborhood Hits	387	Shared Neighborhood Hits	106
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

KIT_HUMAN
θ value	0.365318 (rank : 389)	NC score	0.196449 (rank : 375)
Query Neighborhood Hits	485	Target Neighborhood Hits	953	Shared Neighborhood Hits	208
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

LRC21_HUMAN
θ value	0.365318 (rank : 390)	NC score	0.245116 (rank : 291)
Query Neighborhood Hits	485	Target Neighborhood Hits	456	Shared Neighborhood Hits	216
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

SIG12_HUMAN
θ value	0.365318 (rank : 391)	NC score	0.221941 (rank : 324)
Query Neighborhood Hits	485	Target Neighborhood Hits	245	Shared Neighborhood Hits	197
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

SIGL6_HUMAN
θ value	0.365318 (rank : 392)	NC score	0.220660 (rank : 327)
Query Neighborhood Hits	485	Target Neighborhood Hits	233	Shared Neighborhood Hits	179
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

TRIM9_HUMAN
θ value	0.365318 (rank : 393)	NC score	0.064819 (rank : 672)
Query Neighborhood Hits	485	Target Neighborhood Hits	294	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

CEAM8_HUMAN
θ value	0.47712 (rank : 394)	NC score	0.251066 (rank : 282)
Query Neighborhood Hits	485	Target Neighborhood Hits	264	Shared Neighborhood Hits	186
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

EP400_MOUSE
θ value	0.47712 (rank : 395)	NC score	0.002856 (rank : 876)
Query Neighborhood Hits	485	Target Neighborhood Hits	592	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

INAR1_HUMAN
θ value	0.47712 (rank : 396)	NC score	0.037881 (rank : 829)
Query Neighborhood Hits	485	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	P17181, Q53GW9, Q53H11, Q8WTZ2	Gene names	IFNAR1, IFNAR
Domain Architecture	No domain graphic available
Description	Interferon-alpha/beta receptor alpha chain precursor (IFN-alpha-REC).

LRRN5_HUMAN
θ value	0.47712 (rank : 397)	NC score	0.202465 (rank : 367)
Query Neighborhood Hits	485	Target Neighborhood Hits	493	Shared Neighborhood Hits	216
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

VSIG2_HUMAN
θ value	0.47712 (rank : 398)	NC score	0.378430 (rank : 204)
Query Neighborhood Hits	485	Target Neighborhood Hits	321	Shared Neighborhood Hits	212
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

BT3A2_HUMAN
θ value	0.62314 (rank : 399)	NC score	0.084350 (rank : 580)
Query Neighborhood Hits	485	Target Neighborhood Hits	158	Shared Neighborhood Hits	77
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

HUG1_HUMAN
θ value	0.62314 (rank : 400)	NC score	0.017059 (rank : 855)
Query Neighborhood Hits	485	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O75698	Gene names	HUG1, C10orf1
Domain Architecture	No domain graphic available
Description	Protein HUG-1 (HOX11 upstream gene 1 protein).

BT1A1_HUMAN
θ value	0.813845 (rank : 401)	NC score	0.056989 (rank : 724)
Query Neighborhood Hits	485	Target Neighborhood Hits	322	Shared Neighborhood Hits	104
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

CC14B_HUMAN
θ value	0.813845 (rank : 402)	NC score	0.116465 (rank : 465)
Query Neighborhood Hits	485	Target Neighborhood Hits	114	Shared Neighborhood Hits	66
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CILP1_MOUSE
θ value	0.813845 (rank : 403)	NC score	0.230290 (rank : 307)
Query Neighborhood Hits	485	Target Neighborhood Hits	282	Shared Neighborhood Hits	177
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

FANK1_MOUSE
θ value	0.813845 (rank : 404)	NC score	0.028480 (rank : 838)
Query Neighborhood Hits	485	Target Neighborhood Hits	325	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

IGS4B_HUMAN
θ value	0.813845 (rank : 405)	NC score	0.364341 (rank : 217)
Query Neighborhood Hits	485	Target Neighborhood Hits	305	Shared Neighborhood Hits	207
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

MUCM_MOUSE
θ value	0.813845 (rank : 406)	NC score	0.040796 (rank : 827)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

MUC_MOUSE
θ value	0.813845 (rank : 407)	NC score	0.041251 (rank : 826)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

NALP1_HUMAN
θ value	0.813845 (rank : 408)	NC score	0.003355 (rank : 874)
Query Neighborhood Hits	485	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

ASM3A_HUMAN
θ value	1.06291 (rank : 409)	NC score	0.013538 (rank : 860)
Query Neighborhood Hits	485	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q92484, Q8WV13	Gene names	SMPDL3A, ASML3A
Domain Architecture	No domain graphic available
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

GHR_HUMAN
θ value	1.06291 (rank : 410)	NC score	0.031186 (rank : 837)
Query Neighborhood Hits	485	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

IGHA_MOUSE
θ value	1.06291 (rank : 411)	NC score	0.023542 (rank : 844)
Query Neighborhood Hits	485	Target Neighborhood Hits	196	Shared Neighborhood Hits	19
SwissProt Accessions	P01878	Gene names
Domain Architecture
Description	Ig alpha chain C region.

IL18R_HUMAN
θ value	1.06291 (rank : 412)	NC score	0.035321 (rank : 831)
Query Neighborhood Hits	485	Target Neighborhood Hits	81	Shared Neighborhood Hits	34
SwissProt Accessions	Q13478	Gene names	IL18R1, IL1RRP
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp) (CDw218a antigen).

CC14A_HUMAN
θ value	1.38821 (rank : 413)	NC score	0.104239 (rank : 529)
Query Neighborhood Hits	485	Target Neighborhood Hits	133	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_MOUSE
θ value	1.38821 (rank : 414)	NC score	0.106572 (rank : 511)
Query Neighborhood Hits	485	Target Neighborhood Hits	117	Shared Neighborhood Hits	64
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CT075_MOUSE
θ value	1.38821 (rank : 415)	NC score	0.120457 (rank : 454)
Query Neighborhood Hits	485	Target Neighborhood Hits	358	Shared Neighborhood Hits	88
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

IL4RA_HUMAN
θ value	1.38821 (rank : 416)	NC score	0.027359 (rank : 839)
Query Neighborhood Hits	485	Target Neighborhood Hits	144	Shared Neighborhood Hits	22
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

MED12_HUMAN
θ value	1.38821 (rank : 417)	NC score	0.006594 (rank : 870)
Query Neighborhood Hits	485	Target Neighborhood Hits	262	Shared Neighborhood Hits	7
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

PGFRL_HUMAN
θ value	1.38821 (rank : 418)	NC score	0.187426 (rank : 386)
Query Neighborhood Hits	485	Target Neighborhood Hits	115	Shared Neighborhood Hits	107
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

SIGL8_HUMAN
θ value	1.38821 (rank : 419)	NC score	0.236590 (rank : 298)
Query Neighborhood Hits	485	Target Neighborhood Hits	252	Shared Neighborhood Hits	194
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

TBC19_HUMAN
θ value	1.38821 (rank : 420)	NC score	0.012072 (rank : 862)
Query Neighborhood Hits	485	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5T2	Gene names	TBC1D19
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 19.

TRIM9_MOUSE
θ value	1.38821 (rank : 421)	NC score	0.058760 (rank : 705)
Query Neighborhood Hits	485	Target Neighborhood Hits	274	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

UNC5A_HUMAN
θ value	1.38821 (rank : 422)	NC score	0.202826 (rank : 365)
Query Neighborhood Hits	485	Target Neighborhood Hits	198	Shared Neighborhood Hits	118
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5A_MOUSE
θ value	1.38821 (rank : 423)	NC score	0.178985 (rank : 392)
Query Neighborhood Hits	485	Target Neighborhood Hits	203	Shared Neighborhood Hits	115
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

BT1A1_MOUSE
θ value	1.81305 (rank : 424)	NC score	0.066066 (rank : 662)
Query Neighborhood Hits	485	Target Neighborhood Hits	252	Shared Neighborhood Hits	111
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT3A3_HUMAN
θ value	1.81305 (rank : 425)	NC score	0.049928 (rank : 823)
Query Neighborhood Hits	485	Target Neighborhood Hits	233	Shared Neighborhood Hits	85
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

CRLF2_MOUSE
θ value	1.81305 (rank : 426)	NC score	0.061429 (rank : 689)
Query Neighborhood Hits	485	Target Neighborhood Hits	39	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

DUS13_HUMAN
θ value	1.81305 (rank : 427)	NC score	0.018066 (rank : 854)
Query Neighborhood Hits	485	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UII6, Q5JSC6, Q96GC2	Gene names	DUSP13, TMDP
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal-muscle-specific DSP) (Dual specificity phosphatase SKRP4).

IGS4B_MOUSE
θ value	1.81305 (rank : 428)	NC score	0.374615 (rank : 206)
Query Neighborhood Hits	485	Target Neighborhood Hits	328	Shared Neighborhood Hits	214
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

K0889_HUMAN
θ value	1.81305 (rank : 429)	NC score	0.011998 (rank : 863)
Query Neighborhood Hits	485	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	O94964	Gene names	KIAA0889
Domain Architecture	No domain graphic available
Description	Protein KIAA0889.

RTBDN_MOUSE
θ value	1.81305 (rank : 430)	NC score	0.015128 (rank : 857)
Query Neighborhood Hits	485	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q8QZY4, Q6T898	Gene names	Rtbdn
Domain Architecture	No domain graphic available
Description	Retbindin precursor.

BT3A1_HUMAN
θ value	2.36792 (rank : 431)	NC score	0.047832 (rank : 824)
Query Neighborhood Hits	485	Target Neighborhood Hits	229	Shared Neighborhood Hits	80
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

CN092_HUMAN
θ value	2.36792 (rank : 432)	NC score	0.003313 (rank : 875)
Query Neighborhood Hits	485	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	O94842	Gene names	C14orf92, KIAA0737
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

DUS12_MOUSE
θ value	2.36792 (rank : 433)	NC score	0.011517 (rank : 864)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D0T2, Q9EQD3	Gene names	Dusp12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1).

FANK1_HUMAN
θ value	2.36792 (rank : 434)	NC score	0.027073 (rank : 840)
Query Neighborhood Hits	485	Target Neighborhood Hits	326	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

JAG1_MOUSE
θ value	2.36792 (rank : 435)	NC score	0.038553 (rank : 828)
Query Neighborhood Hits	485	Target Neighborhood Hits	518	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

LEPR_MOUSE
θ value	2.36792 (rank : 436)	NC score	0.107402 (rank : 507)
Query Neighborhood Hits	485	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

PDL2_HUMAN
θ value	2.36792 (rank : 437)	NC score	0.126883 (rank : 445)
Query Neighborhood Hits	485	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PRLR_HUMAN
θ value	2.36792 (rank : 438)	NC score	0.081225 (rank : 591)
Query Neighborhood Hits	485	Target Neighborhood Hits	95	Shared Neighborhood Hits	52
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

DUS11_MOUSE
θ value	3.0926 (rank : 439)	NC score	0.034488 (rank : 833)
Query Neighborhood Hits	485	Target Neighborhood Hits	41	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

FRM4A_HUMAN
θ value	3.0926 (rank : 440)	NC score	0.061013 (rank : 691)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

IL5RA_HUMAN
θ value	3.0926 (rank : 441)	NC score	0.019735 (rank : 852)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	16
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

PSG2_HUMAN
θ value	3.0926 (rank : 442)	NC score	0.218668 (rank : 336)
Query Neighborhood Hits	485	Target Neighborhood Hits	229	Shared Neighborhood Hits	171
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

TDRD6_MOUSE
θ value	3.0926 (rank : 443)	NC score	0.008298 (rank : 869)
Query Neighborhood Hits	485	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

UROL1_MOUSE
θ value	3.0926 (rank : 444)	NC score	0.023749 (rank : 843)
Query Neighborhood Hits	485	Target Neighborhood Hits	235	Shared Neighborhood Hits	26
SwissProt Accessions	Q5DID3, Q5DID1, Q5DID2	Gene names	Umodl1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

CC14B_MOUSE
θ value	4.03905 (rank : 445)	NC score	0.110454 (rank : 489)
Query Neighborhood Hits	485	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

LRP10_HUMAN
θ value	4.03905 (rank : 446)	NC score	0.025414 (rank : 841)
Query Neighborhood Hits	485	Target Neighborhood Hits	197	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

RIMB1_MOUSE
θ value	4.03905 (rank : 447)	NC score	0.020720 (rank : 849)
Query Neighborhood Hits	485	Target Neighborhood Hits	1376	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SHD_HUMAN
θ value	4.03905 (rank : 448)	NC score	0.021057 (rank : 848)
Query Neighborhood Hits	485	Target Neighborhood Hits	204	Shared Neighborhood Hits	9
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ECM29_MOUSE
θ value	5.27518 (rank : 449)	NC score	0.002752 (rank : 877)
Query Neighborhood Hits	485	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

GPR98_HUMAN
θ value	5.27518 (rank : 450)	NC score	0.009181 (rank : 868)
Query Neighborhood Hits	485	Target Neighborhood Hits	202	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

PCLO_MOUSE
θ value	5.27518 (rank : 451)	NC score	0.019328 (rank : 853)
Query Neighborhood Hits	485	Target Neighborhood Hits	2275	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PGFRB_HUMAN
θ value	5.27518 (rank : 452)	NC score	0.195488 (rank : 377)
Query Neighborhood Hits	485	Target Neighborhood Hits	962	Shared Neighborhood Hits	212
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRL_MOUSE
θ value	5.27518 (rank : 453)	NC score	0.159412 (rank : 417)
Query Neighborhood Hits	485	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

DUS11_HUMAN
θ value	6.88961 (rank : 454)	NC score	0.024332 (rank : 842)
Query Neighborhood Hits	485	Target Neighborhood Hits	37	Shared Neighborhood Hits	18
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

I28RA_HUMAN
θ value	6.88961 (rank : 455)	NC score	0.020201 (rank : 851)
Query Neighborhood Hits	485	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IU57, Q6ZML8, Q8IZI7, Q8IZI8	Gene names	IL28RA, IFNLR1, LICR2
Domain Architecture	No domain graphic available
Description	Interleukin-28 receptor alpha chain precursor (IL-28R-alpha) (IL-28RA) (Cytokine receptor family 2 member 12) (Cytokine receptor class-II member 12) (CRF2-12) (Interferon lambda receptor 1) (IFN-lambda R1) (Likely interleukin or cytokine receptor 2).

MYC_MOUSE
θ value	6.88961 (rank : 456)	NC score	-0.000931 (rank : 883)
Query Neighborhood Hits	485	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

NGL1_MOUSE
θ value	6.88961 (rank : 457)	NC score	0.159904 (rank : 415)
Query Neighborhood Hits	485	Target Neighborhood Hits	512	Shared Neighborhood Hits	187
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

PCLO_HUMAN
θ value	6.88961 (rank : 458)	NC score	0.006037 (rank : 871)
Query Neighborhood Hits	485	Target Neighborhood Hits	2046	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PGFRB_MOUSE
θ value	6.88961 (rank : 459)	NC score	0.204631 (rank : 361)
Query Neighborhood Hits	485	Target Neighborhood Hits	960	Shared Neighborhood Hits	213
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PRP8_HUMAN
θ value	6.88961 (rank : 460)	NC score	0.005974 (rank : 873)
Query Neighborhood Hits	485	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P2Q9, O14547, O75965	Gene names	PRPF8, PRPC8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) (PRP8 homolog) (220 kDa U5 snRNP-specific protein) (p220).

PRP8_MOUSE
θ value	6.88961 (rank : 461)	NC score	0.005982 (rank : 872)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PV0, Q5ND30, Q5ND31, Q7TQK2, Q8BRZ5, Q8K001	Gene names	Prpf8, Prp8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8).

PSG11_HUMAN
θ value	6.88961 (rank : 462)	NC score	0.224214 (rank : 320)
Query Neighborhood Hits	485	Target Neighborhood Hits	223	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG3_HUMAN
θ value	6.88961 (rank : 463)	NC score	0.236040 (rank : 299)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	178
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

TNR1A_HUMAN
θ value	6.88961 (rank : 464)	NC score	0.000798 (rank : 880)
Query Neighborhood Hits	485	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

ZFN2B_HUMAN
θ value	6.88961 (rank : 465)	NC score	0.014217 (rank : 859)
Query Neighborhood Hits	485	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WV99, Q8NB98	Gene names	ZFAND2B
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 2B.

CELR3_HUMAN
θ value	8.99809 (rank : 466)	NC score	0.010909 (rank : 865)
Query Neighborhood Hits	485	Target Neighborhood Hits	680	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

GC3M_MOUSE
θ value	8.99809 (rank : 467)	NC score	0.010846 (rank : 866)
Query Neighborhood Hits	485	Target Neighborhood Hits	215	Shared Neighborhood Hits	19
SwissProt Accessions	P03987	Gene names
Domain Architecture
Description	Ig gamma-3 chain C region, membrane-bound form.

GC3_MOUSE
θ value	8.99809 (rank : 468)	NC score	0.010737 (rank : 867)
Query Neighborhood Hits	485	Target Neighborhood Hits	212	Shared Neighborhood Hits	18
SwissProt Accessions	P22436	Gene names
Domain Architecture	No domain graphic available
Description	Ig gamma-3 chain C region, secreted form.

GHR_MOUSE
θ value	8.99809 (rank : 469)	NC score	0.021144 (rank : 847)
Query Neighborhood Hits	485	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	P16882, P16590, Q61653, Q6DI66, Q80W86, Q8R1M5, Q920Z3, Q9R264	Gene names	Ghr
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

ICAM1_MOUSE
θ value	8.99809 (rank : 470)	NC score	0.116439 (rank : 466)
Query Neighborhood Hits	485	Target Neighborhood Hits	99	Shared Neighborhood Hits	83
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

ILRL2_MOUSE
θ value	8.99809 (rank : 471)	NC score	0.172754 (rank : 406)
Query Neighborhood Hits	485	Target Neighborhood Hits	158	Shared Neighborhood Hits	129
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

ITIH1_MOUSE
θ value	8.99809 (rank : 472)	NC score	0.000515 (rank : 881)
Query Neighborhood Hits	485	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

MAGD1_HUMAN
θ value	8.99809 (rank : 473)	NC score	-0.000860 (rank : 882)
Query Neighborhood Hits	485	Target Neighborhood Hits	130	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

MAGD1_MOUSE
θ value	8.99809 (rank : 474)	NC score	0.001718 (rank : 878)
Query Neighborhood Hits	485	Target Neighborhood Hits	136	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

MAML3_HUMAN
θ value	8.99809 (rank : 475)	NC score	0.012712 (rank : 861)
Query Neighborhood Hits	485	Target Neighborhood Hits	323	Shared Neighborhood Hits	18
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

MYO15_MOUSE
θ value	8.99809 (rank : 476)	NC score	0.001093 (rank : 879)
Query Neighborhood Hits	485	Target Neighborhood Hits	467	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NGL1_HUMAN
θ value	8.99809 (rank : 477)	NC score	0.159451 (rank : 416)
Query Neighborhood Hits	485	Target Neighborhood Hits	511	Shared Neighborhood Hits	187
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

PDL2_MOUSE
θ value	8.99809 (rank : 478)	NC score	0.163763 (rank : 413)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	92
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PLK4_HUMAN
θ value	8.99809 (rank : 479)	NC score	0.050946 (rank : 802)
Query Neighborhood Hits	485	Target Neighborhood Hits	884	Shared Neighborhood Hits	86
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PSG7_HUMAN
θ value	8.99809 (rank : 480)	NC score	0.223544 (rank : 321)
Query Neighborhood Hits	485	Target Neighborhood Hits	239	Shared Neighborhood Hits	175
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

SEM3C_MOUSE
θ value	8.99809 (rank : 481)	NC score	0.020646 (rank : 850)
Query Neighborhood Hits	485	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

TRI18_MOUSE
θ value	8.99809 (rank : 482)	NC score	0.021829 (rank : 846)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	34
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRI36_HUMAN
θ value	8.99809 (rank : 483)	NC score	0.015261 (rank : 856)
Query Neighborhood Hits	485	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ86	Gene names	TRIM36, RBCC728, RNF98
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Zinc-binding protein Rbcc728) (RING finger protein 98).

TRI36_MOUSE
θ value	8.99809 (rank : 484)	NC score	0.021861 (rank : 845)
Query Neighborhood Hits	485	Target Neighborhood Hits	266	Shared Neighborhood Hits	39
SwissProt Accessions	Q80WG7, Q7TNM1	Gene names	Trim36
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Haprin) (Acrosome RBCC protein).

TRI42_HUMAN
θ value	8.99809 (rank : 485)	NC score	0.044671 (rank : 825)
Query Neighborhood Hits	485	Target Neighborhood Hits	283	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

41_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.066351 (rank : 660)
Query Neighborhood Hits	485	Target Neighborhood Hits	157	Shared Neighborhood Hits	15
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.066054 (rank : 664)
Query Neighborhood Hits	485	Target Neighborhood Hits	184	Shared Neighborhood Hits	15
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

A1BG_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.057087 (rank : 721)
Query Neighborhood Hits	485	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

AATK_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.109146 (rank : 499)
Query Neighborhood Hits	485	Target Neighborhood Hits	1243	Shared Neighborhood Hits	94
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.111057 (rank : 486)
Query Neighborhood Hits	485	Target Neighborhood Hits	942	Shared Neighborhood Hits	87
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.105015 (rank : 518)
Query Neighborhood Hits	485	Target Neighborhood Hits	1220	Shared Neighborhood Hits	94
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.105523 (rank : 514)
Query Neighborhood Hits	485	Target Neighborhood Hits	1178	Shared Neighborhood Hits	97
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.105467 (rank : 515)
Query Neighborhood Hits	485	Target Neighborhood Hits	1045	Shared Neighborhood Hits	93
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.110401 (rank : 490)
Query Neighborhood Hits	485	Target Neighborhood Hits	1140	Shared Neighborhood Hits	91
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.111795 (rank : 481)
Query Neighborhood Hits	485	Target Neighborhood Hits	1080	Shared Neighborhood Hits	91
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.052830 (rank : 773)
Query Neighborhood Hits	485	Target Neighborhood Hits	753	Shared Neighborhood Hits	82
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.053220 (rank : 770)
Query Neighborhood Hits	485	Target Neighborhood Hits	753	Shared Neighborhood Hits	82
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.056685 (rank : 728)
Query Neighborhood Hits	485	Target Neighborhood Hits	709	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.054063 (rank : 758)
Query Neighborhood Hits	485	Target Neighborhood Hits	715	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.064110 (rank : 681)
Query Neighborhood Hits	485	Target Neighborhood Hits	716	Shared Neighborhood Hits	77
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.067088 (rank : 657)
Query Neighborhood Hits	485	Target Neighborhood Hits	739	Shared Neighborhood Hits	78
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.054588 (rank : 755)
Query Neighborhood Hits	485	Target Neighborhood Hits	760	Shared Neighborhood Hits	81
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.055235 (rank : 744)
Query Neighborhood Hits	485	Target Neighborhood Hits	768	Shared Neighborhood Hits	81
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ALK_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.123697 (rank : 450)
Query Neighborhood Hits	485	Target Neighborhood Hits	795	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.125050 (rank : 448)
Query Neighborhood Hits	485	Target Neighborhood Hits	811	Shared Neighborhood Hits	92
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMGO1_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.057464 (rank : 717)
Query Neighborhood Hits	485	Target Neighborhood Hits	353	Shared Neighborhood Hits	90
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

AMGO2_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.080964 (rank : 593)
Query Neighborhood Hits	485	Target Neighborhood Hits	357	Shared Neighborhood Hits	120
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

AMGO2_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.067593 (rank : 653)
Query Neighborhood Hits	485	Target Neighborhood Hits	329	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

AMGO3_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.065425 (rank : 669)
Query Neighborhood Hits	485	Target Neighborhood Hits	276	Shared Neighborhood Hits	73
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

AMGO3_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.060776 (rank : 694)
Query Neighborhood Hits	485	Target Neighborhood Hits	276	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ANGL6_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.050260 (rank : 820)
Query Neighborhood Hits	485	Target Neighborhood Hits	63	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R0Z6	Gene names	Angptl6, Agf
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 6 precursor (Angiopoietin-like 6) (Angiopoietin-related growth factor).

ANKK1_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.052838 (rank : 772)
Query Neighborhood Hits	485	Target Neighborhood Hits	1075	Shared Neighborhood Hits	85
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.054655 (rank : 754)
Query Neighborhood Hits	485	Target Neighborhood Hits	1072	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.069188 (rank : 643)
Query Neighborhood Hits	485	Target Neighborhood Hits	612	Shared Neighborhood Hits	79
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.070078 (rank : 640)
Query Neighborhood Hits	485	Target Neighborhood Hits	600	Shared Neighborhood Hits	79
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.064656 (rank : 677)
Query Neighborhood Hits	485	Target Neighborhood Hits	646	Shared Neighborhood Hits	79
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.063821 (rank : 682)
Query Neighborhood Hits	485	Target Neighborhood Hits	607	Shared Neighborhood Hits	79
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.081031 (rank : 592)
Query Neighborhood Hits	485	Target Neighborhood Hits	924	Shared Neighborhood Hits	85
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.080963 (rank : 594)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

AVR2A_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.051117 (rank : 799)
Query Neighborhood Hits	485	Target Neighborhood Hits	767	Shared Neighborhood Hits	80
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.051119 (rank : 797)
Query Neighborhood Hits	485	Target Neighborhood Hits	767	Shared Neighborhood Hits	80
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BLK_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.103534 (rank : 532)
Query Neighborhood Hits	485	Target Neighborhood Hits	994	Shared Neighborhood Hits	90
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.104669 (rank : 522)
Query Neighborhood Hits	485	Target Neighborhood Hits	992	Shared Neighborhood Hits	91
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMPR2_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.056532 (rank : 729)
Query Neighborhood Hits	485	Target Neighborhood Hits	736	Shared Neighborhood Hits	79
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.055088 (rank : 749)
Query Neighborhood Hits	485	Target Neighborhood Hits	738	Shared Neighborhood Hits	79
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.057219 (rank : 719)
Query Neighborhood Hits	485	Target Neighborhood Hits	759	Shared Neighborhood Hits	82
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.057045 (rank : 722)
Query Neighborhood Hits	485	Target Neighborhood Hits	758	Shared Neighborhood Hits	82
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.056022 (rank : 732)
Query Neighborhood Hits	485	Target Neighborhood Hits	760	Shared Neighborhood Hits	80
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.056887 (rank : 726)
Query Neighborhood Hits	485	Target Neighborhood Hits	758	Shared Neighborhood Hits	80
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.104523 (rank : 524)
Query Neighborhood Hits	485	Target Neighborhood Hits	942	Shared Neighborhood Hits	88
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.105294 (rank : 517)
Query Neighborhood Hits	485	Target Neighborhood Hits	912	Shared Neighborhood Hits	88
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.080822 (rank : 596)
Query Neighborhood Hits	485	Target Neighborhood Hits	883	Shared Neighborhood Hits	86
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BTK_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.103772 (rank : 530)
Query Neighborhood Hits	485	Target Neighborhood Hits	1026	Shared Neighborhood Hits	92
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.103540 (rank : 531)
Query Neighborhood Hits	485	Target Neighborhood Hits	1017	Shared Neighborhood Hits	92
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTNL2_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.082367 (rank : 582)
Query Neighborhood Hits	485	Target Neighborhood Hits	164	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

CD166_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.286618 (rank : 252)
Query Neighborhood Hits	485	Target Neighborhood Hits	247	Shared Neighborhood Hits	172
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

CD166_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.311664 (rank : 237)
Query Neighborhood Hits	485	Target Neighborhood Hits	252	Shared Neighborhood Hits	176
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CD226_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.052596 (rank : 776)
Query Neighborhood Hits	485	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

CD276_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.217027 (rank : 341)
Query Neighborhood Hits	485	Target Neighborhood Hits	261	Shared Neighborhood Hits	134
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

CD276_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.174807 (rank : 398)
Query Neighborhood Hits	485	Target Neighborhood Hits	243	Shared Neighborhood Hits	143
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CD2L7_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.050299 (rank : 818)
Query Neighborhood Hits	485	Target Neighborhood Hits	1275	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CD4_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.085573 (rank : 579)
Query Neighborhood Hits	485	Target Neighborhood Hits	122	Shared Neighborhood Hits	50
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

CD79A_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.118771 (rank : 460)
Query Neighborhood Hits	485	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

CD80_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.120696 (rank : 453)
Query Neighborhood Hits	485	Target Neighborhood Hits	129	Shared Neighborhood Hits	88
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

CD80_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.105901 (rank : 513)
Query Neighborhood Hits	485	Target Neighborhood Hits	136	Shared Neighborhood Hits	89
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

CDK4_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.051250 (rank : 791)
Query Neighborhood Hits	485	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK6_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.050153 (rank : 821)
Query Neighborhood Hits	485	Target Neighborhood Hits	837	Shared Neighborhood Hits	84
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDKN3_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.058739 (rank : 706)
Query Neighborhood Hits	485	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

CEA20_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.353598 (rank : 224)
Query Neighborhood Hits	485	Target Neighborhood Hits	251	Shared Neighborhood Hits	182
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

CEAM7_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.146486 (rank : 429)
Query Neighborhood Hits	485	Target Neighborhood Hits	170	Shared Neighborhood Hits	119
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

CNTFR_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.050279 (rank : 819)
Query Neighborhood Hits	485	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CNTFR_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.052685 (rank : 775)
Query Neighborhood Hits	485	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CSK_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.104254 (rank : 528)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	93
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.102480 (rank : 541)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	93
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CXAR_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.224460 (rank : 318)
Query Neighborhood Hits	485	Target Neighborhood Hits	245	Shared Neighborhood Hits	139
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

CXAR_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.216597 (rank : 343)
Query Neighborhood Hits	485	Target Neighborhood Hits	250	Shared Neighborhood Hits	140
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

DAPK2_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.052206 (rank : 780)
Query Neighborhood Hits	485	Target Neighborhood Hits	832	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.052774 (rank : 774)
Query Neighborhood Hits	485	Target Neighborhood Hits	834	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.052850 (rank : 771)
Query Neighborhood Hits	485	Target Neighborhood Hits	945	Shared Neighborhood Hits	84
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.052296 (rank : 779)
Query Neighborhood Hits	485	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DDR1_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.119294 (rank : 458)
Query Neighborhood Hits	485	Target Neighborhood Hits	819	Shared Neighborhood Hits	87
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.119170 (rank : 459)
Query Neighborhood Hits	485	Target Neighborhood Hits	818	Shared Neighborhood Hits	87
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.116360 (rank : 467)
Query Neighborhood Hits	485	Target Neighborhood Hits	818	Shared Neighborhood Hits	84
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.115319 (rank : 471)
Query Neighborhood Hits	485	Target Neighborhood Hits	813	Shared Neighborhood Hits	84
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

E2AK2_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.053910 (rank : 763)
Query Neighborhood Hits	485	Target Neighborhood Hits	856	Shared Neighborhood Hits	83
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.051814 (rank : 785)
Query Neighborhood Hits	485	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E41L1_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.064458 (rank : 679)
Query Neighborhood Hits	485	Target Neighborhood Hits	180	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.064781 (rank : 673)
Query Neighborhood Hits	485	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.065837 (rank : 666)
Query Neighborhood Hits	485	Target Neighborhood Hits	287	Shared Neighborhood Hits	14
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.061272 (rank : 690)
Query Neighborhood Hits	485	Target Neighborhood Hits	459	Shared Neighborhood Hits	14
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.067627 (rank : 652)
Query Neighborhood Hits	485	Target Neighborhood Hits	113	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.064574 (rank : 678)
Query Neighborhood Hits	485	Target Neighborhood Hits	250	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.068283 (rank : 648)
Query Neighborhood Hits	485	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.071029 (rank : 637)
Query Neighborhood Hits	485	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.071228 (rank : 635)
Query Neighborhood Hits	485	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.067187 (rank : 656)
Query Neighborhood Hits	485	Target Neighborhood Hits	79	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.068787 (rank : 646)
Query Neighborhood Hits	485	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EGFR_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.108294 (rank : 506)
Query Neighborhood Hits	485	Target Neighborhood Hits	939	Shared Neighborhood Hits	88
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.109045 (rank : 500)
Query Neighborhood Hits	485	Target Neighborhood Hits	927	Shared Neighborhood Hits	91
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EMB_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.092130 (rank : 570)
Query Neighborhood Hits	485	Target Neighborhood Hits	54	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

EMB_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.174206 (rank : 400)
Query Neighborhood Hits	485	Target Neighborhood Hits	83	Shared Neighborhood Hits	73
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

ERBB2_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.110340 (rank : 491)
Query Neighborhood Hits	485	Target Neighborhood Hits	1073	Shared Neighborhood Hits	94
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 583)	NC score	0.109679 (rank : 498)
Query Neighborhood Hits	485	Target Neighborhood Hits	918	Shared Neighborhood Hits	91
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.110090 (rank : 492)
Query Neighborhood Hits	485	Target Neighborhood Hits	918	Shared Neighborhood Hits	86
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 585)	NC score	0.108788 (rank : 504)
Query Neighborhood Hits	485	Target Neighborhood Hits	898	Shared Neighborhood Hits	84
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.110073 (rank : 493)
Query Neighborhood Hits	485	Target Neighborhood Hits	910	Shared Neighborhood Hits	91
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ESAM_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.237249 (rank : 297)
Query Neighborhood Hits	485	Target Neighborhood Hits	251	Shared Neighborhood Hits	154
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

ESAM_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.220607 (rank : 328)
Query Neighborhood Hits	485	Target Neighborhood Hits	222	Shared Neighborhood Hits	147
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

FAK1_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.111614 (rank : 482)
Query Neighborhood Hits	485	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.111360 (rank : 483)
Query Neighborhood Hits	485	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.111863 (rank : 480)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.111224 (rank : 485)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FARP1_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.055814 (rank : 735)
Query Neighborhood Hits	485	Target Neighborhood Hits	241	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.053516 (rank : 769)
Query Neighborhood Hits	485	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.054475 (rank : 756)
Query Neighborhood Hits	485	Target Neighborhood Hits	209	Shared Neighborhood Hits	13
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FCERA_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.129247 (rank : 441)
Query Neighborhood Hits	485	Target Neighborhood Hits	150	Shared Neighborhood Hits	106
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCG2A_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.050817 (rank : 806)
Query Neighborhood Hits	485	Target Neighborhood Hits	92	Shared Neighborhood Hits	53
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

FCG2B_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.068140 (rank : 649)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

FCG2C_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.067762 (rank : 651)
Query Neighborhood Hits	485	Target Neighborhood Hits	118	Shared Neighborhood Hits	67
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

FCGR1_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.116352 (rank : 468)
Query Neighborhood Hits	485	Target Neighborhood Hits	145	Shared Neighborhood Hits	90
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

FCGR1_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.091130 (rank : 572)
Query Neighborhood Hits	485	Target Neighborhood Hits	123	Shared Neighborhood Hits	76
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

FCN1_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.058461 (rank : 709)
Query Neighborhood Hits	485	Target Neighborhood Hits	147	Shared Neighborhood Hits	13
SwissProt Accessions	O00602, Q92596	Gene names	FCN1
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

FCN1_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.059807 (rank : 698)
Query Neighborhood Hits	485	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

FCN2_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.057011 (rank : 723)
Query Neighborhood Hits	485	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q15485, Q9UC57	Gene names	FCN2
Domain Architecture
Description	Ficolin-2 precursor (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin B) (Serum lectin p35) (EBP-37) (Hucolin) (L- Ficolin).

FCN3_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.056970 (rank : 725)
Query Neighborhood Hits	485	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	O75636, Q6IBJ5, Q8WW86	Gene names	FCN3, HAKA1
Domain Architecture
Description	Ficolin-3 precursor (Collagen/fibrinogen domain-containing protein 3) (Collagen/fibrinogen domain-containing lectin 3 p35) (Hakata antigen).

FCRLA_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.069242 (rank : 642)
Query Neighborhood Hits	485	Target Neighborhood Hits	135	Shared Neighborhood Hits	47
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FCRLA_MOUSE
θ value	θ > 10 (rank : 607)	NC score	0.067206 (rank : 655)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	52
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FER_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.106766 (rank : 510)
Query Neighborhood Hits	485	Target Neighborhood Hits	1278	Shared Neighborhood Hits	91
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.106853 (rank : 509)
Query Neighborhood Hits	485	Target Neighborhood Hits	978	Shared Neighborhood Hits	90
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.106369 (rank : 512)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	88
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.102994 (rank : 537)
Query Neighborhood Hits	485	Target Neighborhood Hits	1067	Shared Neighborhood Hits	93
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.104429 (rank : 525)
Query Neighborhood Hits	485	Target Neighborhood Hits	1069	Shared Neighborhood Hits	93
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FLT3_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.141353 (rank : 434)
Query Neighborhood Hits	485	Target Neighborhood Hits	843	Shared Neighborhood Hits	126
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.155139 (rank : 423)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	135
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FPRP_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.086826 (rank : 576)
Query Neighborhood Hits	485	Target Neighborhood Hits	130	Shared Neighborhood Hits	83
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

FPRP_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.078485 (rank : 603)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

FRK_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.104270 (rank : 526)
Query Neighborhood Hits	485	Target Neighborhood Hits	1058	Shared Neighborhood Hits	89
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FRM4A_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.058143 (rank : 713)
Query Neighborhood Hits	485	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4B_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.059014 (rank : 701)
Query Neighborhood Hits	485	Target Neighborhood Hits	117	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.060883 (rank : 693)
Query Neighborhood Hits	485	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

FRMD1_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.075737 (rank : 617)
Query Neighborhood Hits	485	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

FRMD5_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.065866 (rank : 665)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.066467 (rank : 658)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD6_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.071727 (rank : 633)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.073353 (rank : 632)
Query Neighborhood Hits	485	Target Neighborhood Hits	63	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

FYN_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.099954 (rank : 553)
Query Neighborhood Hits	485	Target Neighborhood Hits	1078	Shared Neighborhood Hits	91
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.100942 (rank : 552)
Query Neighborhood Hits	485	Target Neighborhood Hits	1073	Shared Neighborhood Hits	91
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GP116_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.053613 (rank : 766)
Query Neighborhood Hits	485	Target Neighborhood Hits	167	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

GPA33_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.283814 (rank : 255)
Query Neighborhood Hits	485	Target Neighborhood Hits	273	Shared Neighborhood Hits	164
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

GPA33_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.306452 (rank : 239)
Query Neighborhood Hits	485	Target Neighborhood Hits	294	Shared Neighborhood Hits	168
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

GUC2C_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.088403 (rank : 574)
Query Neighborhood Hits	485	Target Neighborhood Hits	624	Shared Neighborhood Hits	79
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.070875 (rank : 638)
Query Neighborhood Hits	485	Target Neighborhood Hits	715	Shared Neighborhood Hits	83
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.076947 (rank : 612)
Query Neighborhood Hits	485	Target Neighborhood Hits	692	Shared Neighborhood Hits	83
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.086650 (rank : 577)
Query Neighborhood Hits	485	Target Neighborhood Hits	740	Shared Neighborhood Hits	83
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 635)	NC score	0.067330 (rank : 654)
Query Neighborhood Hits	485	Target Neighborhood Hits	644	Shared Neighborhood Hits	78
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCK_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.104824 (rank : 520)
Query Neighborhood Hits	485	Target Neighborhood Hits	1035	Shared Neighborhood Hits	92
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.104903 (rank : 519)
Query Neighborhood Hits	485	Target Neighborhood Hits	1029	Shared Neighborhood Hits	90
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

I18RA_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.054671 (rank : 753)
Query Neighborhood Hits	485	Target Neighborhood Hits	97	Shared Neighborhood Hits	55
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

I18RA_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.055399 (rank : 740)
Query Neighborhood Hits	485	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

I27RA_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.093613 (rank : 566)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	40
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

ICAM1_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.093869 (rank : 565)
Query Neighborhood Hits	485	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

ICAM3_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.097967 (rank : 561)
Query Neighborhood Hits	485	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

ICK_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.050807 (rank : 808)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 644)	NC score	0.050573 (rank : 812)
Query Neighborhood Hits	485	Target Neighborhood Hits	860	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IGSF2_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.086004 (rank : 578)
Query Neighborhood Hits	485	Target Neighborhood Hits	208	Shared Neighborhood Hits	85
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

IKKA_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.060415 (rank : 695)
Query Neighborhood Hits	485	Target Neighborhood Hits	863	Shared Neighborhood Hits	84
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.060020 (rank : 696)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.055123 (rank : 747)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	84
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.055000 (rank : 750)
Query Neighborhood Hits	485	Target Neighborhood Hits	984	Shared Neighborhood Hits	85
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IL1AP_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.058135 (rank : 714)
Query Neighborhood Hits	485	Target Neighborhood Hits	94	Shared Neighborhood Hits	51
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

IL1R1_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.182264 (rank : 388)
Query Neighborhood Hits	485	Target Neighborhood Hits	140	Shared Neighborhood Hits	118
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

IL27B_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.077108 (rank : 611)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	41
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

IL6RA_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.077228 (rank : 610)
Query Neighborhood Hits	485	Target Neighborhood Hits	96	Shared Neighborhood Hits	58
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

IL6RA_MOUSE
θ value	θ > 10 (rank : 654)	NC score	0.101955 (rank : 547)
Query Neighborhood Hits	485	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

ILK1_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.081395 (rank : 590)
Query Neighborhood Hits	485	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.079857 (rank : 600)
Query Neighborhood Hits	485	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.081780 (rank : 587)
Query Neighborhood Hits	485	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILRL1_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.158776 (rank : 419)
Query Neighborhood Hits	485	Target Neighborhood Hits	167	Shared Neighborhood Hits	118
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

ILRL1_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.119595 (rank : 457)
Query Neighborhood Hits	485	Target Neighborhood Hits	172	Shared Neighborhood Hits	116
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

ILRL2_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.107290 (rank : 508)
Query Neighborhood Hits	485	Target Neighborhood Hits	112	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

IRAK1_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.064745 (rank : 675)
Query Neighborhood Hits	485	Target Neighborhood Hits	820	Shared Neighborhood Hits	83
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 662)	NC score	0.064779 (rank : 674)
Query Neighborhood Hits	485	Target Neighborhood Hits	784	Shared Neighborhood Hits	85
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.054023 (rank : 760)
Query Neighborhood Hits	485	Target Neighborhood Hits	714	Shared Neighborhood Hits	69
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.073409 (rank : 631)
Query Neighborhood Hits	485	Target Neighborhood Hits	644	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.077346 (rank : 608)
Query Neighborhood Hits	485	Target Neighborhood Hits	628	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.070858 (rank : 639)
Query Neighborhood Hits	485	Target Neighborhood Hits	816	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.069050 (rank : 645)
Query Neighborhood Hits	485	Target Neighborhood Hits	820	Shared Neighborhood Hits	85
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.102258 (rank : 544)
Query Neighborhood Hits	485	Target Neighborhood Hits	1016	Shared Neighborhood Hits	88
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.103204 (rank : 534)
Query Neighborhood Hits	485	Target Neighborhood Hits	985	Shared Neighborhood Hits	88
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.098588 (rank : 558)
Query Neighborhood Hits	485	Target Neighborhood Hits	858	Shared Neighborhood Hits	89
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.099216 (rank : 557)
Query Neighborhood Hits	485	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.094414 (rank : 563)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.094045 (rank : 564)
Query Neighborhood Hits	485	Target Neighborhood Hits	839	Shared Neighborhood Hits	84
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.095397 (rank : 562)
Query Neighborhood Hits	485	Target Neighborhood Hits	827	Shared Neighborhood Hits	84
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.092145 (rank : 569)
Query Neighborhood Hits	485	Target Neighborhood Hits	821	Shared Neighborhood Hits	84
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

JAML1_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.068120 (rank : 650)
Query Neighborhood Hits	485	Target Neighborhood Hits	108	Shared Neighborhood Hits	47
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

JAML1_MOUSE
θ value	θ > 10 (rank : 677)	NC score	0.135847 (rank : 437)
Query Neighborhood Hits	485	Target Neighborhood Hits	185	Shared Neighborhood Hits	96
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

KR171_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.057135 (rank : 720)
Query Neighborhood Hits	485	Target Neighborhood Hits	144	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

KRA51_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.050357 (rank : 815)
Query Neighborhood Hits	485	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KS6A1_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.050092 (rank : 822)
Query Neighborhood Hits	485	Target Neighborhood Hits	854	Shared Neighborhood Hits	84
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.050334 (rank : 816)
Query Neighborhood Hits	485	Target Neighborhood Hits	857	Shared Neighborhood Hits	84
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.050882 (rank : 803)
Query Neighborhood Hits	485	Target Neighborhood Hits	859	Shared Neighborhood Hits	84
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 683)	NC score	0.050844 (rank : 805)
Query Neighborhood Hits	485	Target Neighborhood Hits	860	Shared Neighborhood Hits	84
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KSR1_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.076024 (rank : 616)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.075063 (rank : 621)
Query Neighborhood Hits	485	Target Neighborhood Hits	870	Shared Neighborhood Hits	87
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.066417 (rank : 659)
Query Neighborhood Hits	485	Target Neighborhood Hits	920	Shared Neighborhood Hits	86
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.112428 (rank : 475)
Query Neighborhood Hits	485	Target Neighborhood Hits	901	Shared Neighborhood Hits	89
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.112962 (rank : 474)
Query Neighborhood Hits	485	Target Neighborhood Hits	944	Shared Neighborhood Hits	90
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAG3_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.101055 (rank : 551)
Query Neighborhood Hits	485	Target Neighborhood Hits	129	Shared Neighborhood Hits	64
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LAG3_MOUSE
θ value	θ > 10 (rank : 690)	NC score	0.111317 (rank : 484)
Query Neighborhood Hits	485	Target Neighborhood Hits	117	Shared Neighborhood Hits	70
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

LAMA5_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.051865 (rank : 783)
Query Neighborhood Hits	485	Target Neighborhood Hits	976	Shared Neighborhood Hits	63
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMA5_MOUSE
θ value	θ > 10 (rank : 692)	NC score	0.050634 (rank : 811)
Query Neighborhood Hits	485	Target Neighborhood Hits	828	Shared Neighborhood Hits	61
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LCK_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.105299 (rank : 516)
Query Neighborhood Hits	485	Target Neighborhood Hits	987	Shared Neighborhood Hits	91
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.104733 (rank : 521)
Query Neighborhood Hits	485	Target Neighborhood Hits	981	Shared Neighborhood Hits	89
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LIMK1_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.074505 (rank : 623)
Query Neighborhood Hits	485	Target Neighborhood Hits	1005	Shared Neighborhood Hits	86
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 696)	NC score	0.074281 (rank : 625)
Query Neighborhood Hits	485	Target Neighborhood Hits	1008	Shared Neighborhood Hits	87
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.074802 (rank : 622)
Query Neighborhood Hits	485	Target Neighborhood Hits	986	Shared Neighborhood Hits	87
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.075158 (rank : 620)
Query Neighborhood Hits	485	Target Neighborhood Hits	998	Shared Neighborhood Hits	87
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRC4B_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.159301 (rank : 418)
Query Neighborhood Hits	485	Target Neighborhood Hits	479	Shared Neighborhood Hits	189
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC4B_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.161679 (rank : 414)
Query Neighborhood Hits	485	Target Neighborhood Hits	484	Shared Neighborhood Hits	191
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRRC4_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.143845 (rank : 432)
Query Neighborhood Hits	485	Target Neighborhood Hits	444	Shared Neighborhood Hits	174
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

LRRC4_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.123005 (rank : 451)
Query Neighborhood Hits	485	Target Neighborhood Hits	412	Shared Neighborhood Hits	152
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

LRRK1_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.075489 (rank : 619)
Query Neighborhood Hits	485	Target Neighborhood Hits	1237	Shared Neighborhood Hits	113
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.077284 (rank : 609)
Query Neighborhood Hits	485	Target Neighborhood Hits	1267	Shared Neighborhood Hits	112
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.066065 (rank : 663)
Query Neighborhood Hits	485	Target Neighborhood Hits	1382	Shared Neighborhood Hits	109
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.063737 (rank : 683)
Query Neighborhood Hits	485	Target Neighborhood Hits	1359	Shared Neighborhood Hits	110
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.126495 (rank : 446)
Query Neighborhood Hits	485	Target Neighborhood Hits	774	Shared Neighborhood Hits	85
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.126024 (rank : 447)
Query Neighborhood Hits	485	Target Neighborhood Hits	770	Shared Neighborhood Hits	84
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LY9_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.057623 (rank : 715)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	57
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

LYN_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.102360 (rank : 543)
Query Neighborhood Hits	485	Target Neighborhood Hits	1022	Shared Neighborhood Hits	89
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.102624 (rank : 540)
Query Neighborhood Hits	485	Target Neighborhood Hits	1023	Shared Neighborhood Hits	91
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.080928 (rank : 595)
Query Neighborhood Hits	485	Target Neighborhood Hits	1071	Shared Neighborhood Hits	89
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.079994 (rank : 599)
Query Neighborhood Hits	485	Target Neighborhood Hits	1136	Shared Neighborhood Hits	94
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.081860 (rank : 585)
Query Neighborhood Hits	485	Target Neighborhood Hits	940	Shared Neighborhood Hits	88
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.081653 (rank : 589)
Query Neighborhood Hits	485	Target Neighborhood Hits	957	Shared Neighborhood Hits	88
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.079424 (rank : 602)
Query Neighborhood Hits	485	Target Neighborhood Hits	911	Shared Neighborhood Hits	84
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K7_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.077694 (rank : 607)
Query Neighborhood Hits	485	Target Neighborhood Hits	892	Shared Neighborhood Hits	84
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.077755 (rank : 606)
Query Neighborhood Hits	485	Target Neighborhood Hits	892	Shared Neighborhood Hits	84
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K9_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.080739 (rank : 597)
Query Neighborhood Hits	485	Target Neighborhood Hits	1123	Shared Neighborhood Hits	91
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.083526 (rank : 581)
Query Neighborhood Hits	485	Target Neighborhood Hits	1087	Shared Neighborhood Hits	88
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MAK_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.051212 (rank : 792)
Query Neighborhood Hits	485	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 722)	NC score	0.051592 (rank : 787)
Query Neighborhood Hits	485	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAMC2_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.098406 (rank : 559)
Query Neighborhood Hits	485	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAMC2_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.101074 (rank : 550)
Query Neighborhood Hits	485	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MATK_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.109750 (rank : 496)
Query Neighborhood Hits	485	Target Neighborhood Hits	954	Shared Neighborhood Hits	89
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.109032 (rank : 501)
Query Neighborhood Hits	485	Target Neighborhood Hits	952	Shared Neighborhood Hits	89
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MERL_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.055260 (rank : 742)
Query Neighborhood Hits	485	Target Neighborhood Hits	532	Shared Neighborhood Hits	12
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.055476 (rank : 737)
Query Neighborhood Hits	485	Target Neighborhood Hits	524	Shared Neighborhood Hits	12
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MET_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.112055 (rank : 478)
Query Neighborhood Hits	485	Target Neighborhood Hits	831	Shared Neighborhood Hits	85
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.112093 (rank : 477)
Query Neighborhood Hits	485	Target Neighborhood Hits	844	Shared Neighborhood Hits	84
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MFAP3_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.101099 (rank : 549)
Query Neighborhood Hits	485	Target Neighborhood Hits	91	Shared Neighborhood Hits	76
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MFAP3_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.088811 (rank : 573)
Query Neighborhood Hits	485	Target Neighborhood Hits	97	Shared Neighborhood Hits	80
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

MFAP4_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.053931 (rank : 762)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	P55083, Q6P680	Gene names	MFAP4
Domain Architecture
Description	Microfibril-associated glycoprotein 4 precursor.

MFAP4_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.054025 (rank : 759)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D1H9, Q5NCN1	Gene names	Mfap4
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 4 precursor.

MLKL_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.087559 (rank : 575)
Query Neighborhood Hits	485	Target Neighborhood Hits	600	Shared Neighborhood Hits	79
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.082349 (rank : 583)
Query Neighborhood Hits	485	Target Neighborhood Hits	707	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.081801 (rank : 586)
Query Neighborhood Hits	485	Target Neighborhood Hits	911	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.081988 (rank : 584)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.076315 (rank : 615)
Query Neighborhood Hits	485	Target Neighborhood Hits	829	Shared Neighborhood Hits	84
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.071113 (rank : 636)
Query Neighborhood Hits	485	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOX2R_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.081679 (rank : 588)
Query Neighborhood Hits	485	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MOX2R_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.181566 (rank : 389)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MP2K5_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.055099 (rank : 748)
Query Neighborhood Hits	485	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.055339 (rank : 741)
Query Neighborhood Hits	485	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MST4_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.058433 (rank : 710)
Query Neighborhood Hits	485	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.058336 (rank : 711)
Query Neighborhood Hits	485	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYLIP_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.060958 (rank : 692)
Query Neighborhood Hits	485	Target Neighborhood Hits	162	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.064697 (rank : 676)
Query Neighborhood Hits	485	Target Neighborhood Hits	139	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLK2_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.055925 (rank : 733)
Query Neighborhood Hits	485	Target Neighborhood Hits	920	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NAGPA_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.059357 (rank : 700)
Query Neighborhood Hits	485	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NAGPA_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.061691 (rank : 688)
Query Neighborhood Hits	485	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NEK11_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.058609 (rank : 707)
Query Neighborhood Hits	485	Target Neighborhood Hits	1043	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.059414 (rank : 699)
Query Neighborhood Hits	485	Target Neighborhood Hits	875	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.051312 (rank : 790)
Query Neighborhood Hits	485	Target Neighborhood Hits	1311	Shared Neighborhood Hits	90
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK3_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.050713 (rank : 810)
Query Neighborhood Hits	485	Target Neighborhood Hits	865	Shared Neighborhood Hits	84
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.050303 (rank : 817)
Query Neighborhood Hits	485	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.055431 (rank : 739)
Query Neighborhood Hits	485	Target Neighborhood Hits	883	Shared Neighborhood Hits	84
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.055210 (rank : 745)
Query Neighborhood Hits	485	Target Neighborhood Hits	899	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.056023 (rank : 731)
Query Neighborhood Hits	485	Target Neighborhood Hits	848	Shared Neighborhood Hits	84
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.055881 (rank : 734)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.057435 (rank : 718)
Query Neighborhood Hits	485	Target Neighborhood Hits	846	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.057489 (rank : 716)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NRG1_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.248599 (rank : 287)
Query Neighborhood Hits	485	Target Neighborhood Hits	285	Shared Neighborhood Hits	152
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

NTRK1_HUMAN
θ value	θ > 10 (rank : 764)	NC score	0.157757 (rank : 421)
Query Neighborhood Hits	485	Target Neighborhood Hits	1023	Shared Neighborhood Hits	183
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NUAK2_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.050543 (rank : 813)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

OX2G_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.104630 (rank : 523)
Query Neighborhood Hits	485	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

OX2G_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.124890 (rank : 449)
Query Neighborhood Hits	485	Target Neighborhood Hits	105	Shared Neighborhood Hits	74
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

OXSR1_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.051129 (rank : 796)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 769)	NC score	0.050811 (rank : 807)
Query Neighborhood Hits	485	Target Neighborhood Hits	865	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK6_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.050475 (rank : 814)
Query Neighborhood Hits	485	Target Neighborhood Hits	915	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PDL1_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.177296 (rank : 396)
Query Neighborhood Hits	485	Target Neighborhood Hits	195	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL1_MOUSE
θ value	θ > 10 (rank : 772)	NC score	0.144591 (rank : 430)
Query Neighborhood Hits	485	Target Neighborhood Hits	168	Shared Neighborhood Hits	106
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PECA1_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.192426 (rank : 380)
Query Neighborhood Hits	485	Target Neighborhood Hits	178	Shared Neighborhood Hits	128
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

PECA1_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.143435 (rank : 433)
Query Neighborhood Hits	485	Target Neighborhood Hits	126	Shared Neighborhood Hits	88
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

PIGR_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.173636 (rank : 404)
Query Neighborhood Hits	485	Target Neighborhood Hits	164	Shared Neighborhood Hits	96
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PIGR_MOUSE
θ value	θ > 10 (rank : 776)	NC score	0.181274 (rank : 390)
Query Neighborhood Hits	485	Target Neighborhood Hits	214	Shared Neighborhood Hits	116
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

PLK4_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.050864 (rank : 804)
Query Neighborhood Hits	485	Target Neighborhood Hits	879	Shared Neighborhood Hits	84
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PRLR_MOUSE
θ value	θ > 10 (rank : 778)	NC score	0.076894 (rank : 613)
Query Neighborhood Hits	485	Target Neighborhood Hits	82	Shared Neighborhood Hits	44
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PSG10_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.212880 (rank : 350)
Query Neighborhood Hits	485	Target Neighborhood Hits	227	Shared Neighborhood Hits	164
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG1_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.217237 (rank : 340)
Query Neighborhood Hits	485	Target Neighborhood Hits	232	Shared Neighborhood Hits	175
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PSG4_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.230303 (rank : 306)
Query Neighborhood Hits	485	Target Neighborhood Hits	243	Shared Neighborhood Hits	176
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

PSG5_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.201220 (rank : 370)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	168
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

PSG6_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.216090 (rank : 344)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	166
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

PSG8_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.231194 (rank : 302)
Query Neighborhood Hits	485	Target Neighborhood Hits	239	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PSG9_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.201836 (rank : 368)
Query Neighborhood Hits	485	Target Neighborhood Hits	221	Shared Neighborhood Hits	165
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

PTK6_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.099882 (rank : 554)
Query Neighborhood Hits	485	Target Neighborhood Hits	1020	Shared Neighborhood Hits	89
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.102167 (rank : 546)
Query Neighborhood Hits	485	Target Neighborhood Hits	1026	Shared Neighborhood Hits	89
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PVRL1_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.171047 (rank : 408)
Query Neighborhood Hits	485	Target Neighborhood Hits	219	Shared Neighborhood Hits	128
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

PVRL1_MOUSE
θ value	θ > 10 (rank : 789)	NC score	0.158251 (rank : 420)
Query Neighborhood Hits	485	Target Neighborhood Hits	201	Shared Neighborhood Hits	123
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

PVRL2_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.119938 (rank : 455)
Query Neighborhood Hits	485	Target Neighborhood Hits	185	Shared Neighborhood Hits	106
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

PVRL2_MOUSE
θ value	θ > 10 (rank : 791)	NC score	0.137131 (rank : 436)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	112
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

PVRL3_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.173695 (rank : 403)
Query Neighborhood Hits	485	Target Neighborhood Hits	204	Shared Neighborhood Hits	124
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

PVRL3_MOUSE
θ value	θ > 10 (rank : 793)	NC score	0.188454 (rank : 385)
Query Neighborhood Hits	485	Target Neighborhood Hits	212	Shared Neighborhood Hits	129
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

PVR_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.146640 (rank : 428)
Query Neighborhood Hits	485	Target Neighborhood Hits	195	Shared Neighborhood Hits	110
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

RAF1_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.079820 (rank : 601)
Query Neighborhood Hits	485	Target Neighborhood Hits	886	Shared Neighborhood Hits	84
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 796)	NC score	0.080473 (rank : 598)
Query Neighborhood Hits	485	Target Neighborhood Hits	886	Shared Neighborhood Hits	85
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RET_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.117456 (rank : 464)
Query Neighborhood Hits	485	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 798)	NC score	0.117889 (rank : 463)
Query Neighborhood Hits	485	Target Neighborhood Hits	884	Shared Neighborhood Hits	87
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIPK1_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.073752 (rank : 628)
Query Neighborhood Hits	485	Target Neighborhood Hits	891	Shared Neighborhood Hits	86
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.074153 (rank : 627)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.073444 (rank : 630)
Query Neighborhood Hits	485	Target Neighborhood Hits	774	Shared Neighborhood Hits	82
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.075690 (rank : 618)
Query Neighborhood Hits	485	Target Neighborhood Hits	776	Shared Neighborhood Hits	83
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.076640 (rank : 614)
Query Neighborhood Hits	485	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 804)	NC score	0.059897 (rank : 697)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.053713 (rank : 765)
Query Neighborhood Hits	485	Target Neighborhood Hits	1094	Shared Neighborhood Hits	86
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.065434 (rank : 667)
Query Neighborhood Hits	485	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.065422 (rank : 670)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.110042 (rank : 494)
Query Neighborhood Hits	485	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.111951 (rank : 479)
Query Neighborhood Hits	485	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RYK_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.131325 (rank : 439)
Query Neighborhood Hits	485	Target Neighborhood Hits	701	Shared Neighborhood Hits	82
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 811)	NC score	0.129680 (rank : 440)
Query Neighborhood Hits	485	Target Neighborhood Hits	715	Shared Neighborhood Hits	81
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SHPS1_HUMAN
θ value	θ > 10 (rank : 812)	NC score	0.103310 (rank : 533)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	107
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

SHPS1_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.064451 (rank : 680)
Query Neighborhood Hits	485	Target Neighborhood Hits	439	Shared Neighborhood Hits	92
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

SIG12_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.140869 (rank : 435)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	140
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

SIGIR_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.062699 (rank : 685)
Query Neighborhood Hits	485	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

SIGL7_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.156461 (rank : 422)
Query Neighborhood Hits	485	Target Neighborhood Hits	180	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

SIGL9_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.066300 (rank : 661)
Query Neighborhood Hits	485	Target Neighborhood Hits	76	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

SIRB1_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.091923 (rank : 571)
Query Neighborhood Hits	485	Target Neighborhood Hits	422	Shared Neighborhood Hits	98
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

SIRPG_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.058321 (rank : 712)
Query Neighborhood Hits	485	Target Neighborhood Hits	359	Shared Neighborhood Hits	76
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

SRC_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.101710 (rank : 548)
Query Neighborhood Hits	485	Target Neighborhood Hits	1058	Shared Neighborhood Hits	92
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 821)	NC score	0.102229 (rank : 545)
Query Neighborhood Hits	485	Target Neighborhood Hits	1033	Shared Neighborhood Hits	92
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SREC2_HUMAN
θ value	θ > 10 (rank : 822)	NC score	0.056054 (rank : 730)
Query Neighborhood Hits	485	Target Neighborhood Hits	645	Shared Neighborhood Hits	48
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SREC2_MOUSE
θ value	θ > 10 (rank : 823)	NC score	0.051846 (rank : 784)
Query Neighborhood Hits	485	Target Neighborhood Hits	605	Shared Neighborhood Hits	42
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.053604 (rank : 767)
Query Neighborhood Hits	485	Target Neighborhood Hits	645	Shared Neighborhood Hits	43
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

SRMS_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.109734 (rank : 497)
Query Neighborhood Hits	485	Target Neighborhood Hits	946	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.108453 (rank : 505)
Query Neighborhood Hits	485	Target Neighborhood Hits	964	Shared Neighborhood Hits	89
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ST17B_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.052373 (rank : 778)
Query Neighborhood Hits	485	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK16_HUMAN
θ value	θ > 10 (rank : 828)	NC score	0.053934 (rank : 761)
Query Neighborhood Hits	485	Target Neighborhood Hits	824	Shared Neighborhood Hits	82
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 829)	NC score	0.053850 (rank : 764)
Query Neighborhood Hits	485	Target Neighborhood Hits	824	Shared Neighborhood Hits	82
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.058778 (rank : 704)
Query Neighborhood Hits	485	Target Neighborhood Hits	853	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 831)	NC score	0.058970 (rank : 702)
Query Neighborhood Hits	485	Target Neighborhood Hits	856	Shared Neighborhood Hits	84
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.055242 (rank : 743)
Query Neighborhood Hits	485	Target Neighborhood Hits	853	Shared Neighborhood Hits	84
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 833)	NC score	0.055501 (rank : 736)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.053596 (rank : 768)
Query Neighborhood Hits	485	Target Neighborhood Hits	879	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK36_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.051155 (rank : 795)
Query Neighborhood Hits	485	Target Neighborhood Hits	896	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 836)	NC score	0.052452 (rank : 777)
Query Neighborhood Hits	485	Target Neighborhood Hits	877	Shared Neighborhood Hits	84
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK39_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.051322 (rank : 789)
Query Neighborhood Hits	485	Target Neighborhood Hits	882	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.051468 (rank : 788)
Query Neighborhood Hits	485	Target Neighborhood Hits	915	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.054290 (rank : 757)
Query Neighborhood Hits	485	Target Neighborhood Hits	861	Shared Neighborhood Hits	85
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.054717 (rank : 752)
Query Neighborhood Hits	485	Target Neighborhood Hits	869	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.054959 (rank : 751)
Query Neighborhood Hits	485	Target Neighborhood Hits	870	Shared Neighborhood Hits	84
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.055131 (rank : 746)
Query Neighborhood Hits	485	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STYK1_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.118417 (rank : 461)
Query Neighborhood Hits	485	Target Neighborhood Hits	786	Shared Neighborhood Hits	86
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.121060 (rank : 452)
Query Neighborhood Hits	485	Target Neighborhood Hits	779	Shared Neighborhood Hits	85
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SUSD1_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.055450 (rank : 738)
Query Neighborhood Hits	485	Target Neighborhood Hits	285	Shared Neighborhood Hits	29
SwissProt Accessions	Q6UWL2, Q5T8V7, Q6P9G7, Q8WU83, Q9H6V2, Q9NTA7	Gene names	SUSD1
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 1 precursor.

TEC_HUMAN
θ value	θ > 10 (rank : 846)	NC score	0.102888 (rank : 538)
Query Neighborhood Hits	485	Target Neighborhood Hits	1006	Shared Neighborhood Hits	89
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 847)	NC score	0.102364 (rank : 542)
Query Neighborhood Hits	485	Target Neighborhood Hits	1006	Shared Neighborhood Hits	89
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.073568 (rank : 629)
Query Neighborhood Hits	485	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 849)	NC score	0.074365 (rank : 624)
Query Neighborhood Hits	485	Target Neighborhood Hits	862	Shared Neighborhood Hits	85
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.078318 (rank : 605)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 851)	NC score	0.078333 (rank : 604)
Query Neighborhood Hits	485	Target Neighborhood Hits	833	Shared Neighborhood Hits	84
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.071564 (rank : 634)
Query Neighborhood Hits	485	Target Neighborhood Hits	1103	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 853)	NC score	0.069057 (rank : 644)
Query Neighborhood Hits	485	Target Neighborhood Hits	1333	Shared Neighborhood Hits	86
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 854)	NC score	0.058567 (rank : 708)
Query Neighborhood Hits	485	Target Neighborhood Hits	755	Shared Neighborhood Hits	83
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 855)	NC score	0.058837 (rank : 703)
Query Neighborhood Hits	485	Target Neighborhood Hits	753	Shared Neighborhood Hits	83
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 856)	NC score	0.063263 (rank : 684)
Query Neighborhood Hits	485	Target Neighborhood Hits	748	Shared Neighborhood Hits	82
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 857)	NC score	0.062412 (rank : 686)
Query Neighborhood Hits	485	Target Neighborhood Hits	748	Shared Neighborhood Hits	83
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TNI3K_HUMAN
θ value	θ > 10 (rank : 858)	NC score	0.065031 (rank : 671)
Query Neighborhood Hits	485	Target Neighborhood Hits	1084	Shared Neighborhood Hits	83
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 859)	NC score	0.065426 (rank : 668)
Query Neighborhood Hits	485	Target Neighborhood Hits	1079	Shared Neighborhood Hits	84
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNK1_HUMAN
θ value	θ > 10 (rank : 860)	NC score	0.113938 (rank : 473)
Query Neighborhood Hits	485	Target Neighborhood Hits	815	Shared Neighborhood Hits	84
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 861)	NC score	0.112163 (rank : 476)
Query Neighborhood Hits	485	Target Neighborhood Hits	806	Shared Neighborhood Hits	89
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.068715 (rank : 647)
Query Neighborhood Hits	485	Target Neighborhood Hits	605	Shared Neighborhood Hits	76
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.069810 (rank : 641)
Query Neighborhood Hits	485	Target Neighborhood Hits	618	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TPSNR_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.062246 (rank : 687)
Query Neighborhood Hits	485	Target Neighborhood Hits	330	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

TPSNR_MOUSE
θ value	θ > 10 (rank : 865)	NC score	0.074255 (rank : 626)
Query Neighborhood Hits	485	Target Neighborhood Hits	336	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

TXK_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.103144 (rank : 535)
Query Neighborhood Hits	485	Target Neighborhood Hits	971	Shared Neighborhood Hits	88
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.104267 (rank : 527)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	89
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.092418 (rank : 568)
Query Neighborhood Hits	485	Target Neighborhood Hits	841	Shared Neighborhood Hits	85
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 869)	NC score	0.093307 (rank : 567)
Query Neighborhood Hits	485	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

ULK1_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.051007 (rank : 801)
Query Neighborhood Hits	485	Target Neighborhood Hits	1121	Shared Neighborhood Hits	90
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 871)	NC score	0.051071 (rank : 800)
Query Neighborhood Hits	485	Target Neighborhood Hits	1214	Shared Neighborhood Hits	96
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 872)	NC score	0.051173 (rank : 794)
Query Neighborhood Hits	485	Target Neighborhood Hits	979	Shared Neighborhood Hits	91
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 873)	NC score	0.050789 (rank : 809)
Query Neighborhood Hits	485	Target Neighborhood Hits	943	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 874)	NC score	0.051603 (rank : 786)
Query Neighborhood Hits	485	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 875)	NC score	0.052055 (rank : 781)
Query Neighborhood Hits	485	Target Neighborhood Hits	872	Shared Neighborhood Hits	84
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

VSIG4_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.313698 (rank : 235)
Query Neighborhood Hits	485	Target Neighborhood Hits	236	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

WIF1_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.052043 (rank : 782)
Query Neighborhood Hits	485	Target Neighborhood Hits	392	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

WIF1_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.051187 (rank : 793)
Query Neighborhood Hits	485	Target Neighborhood Hits	393	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

YES_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.103017 (rank : 536)
Query Neighborhood Hits	485	Target Neighborhood Hits	1059	Shared Neighborhood Hits	94
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 880)	NC score	0.102762 (rank : 539)
Query Neighborhood Hits	485	Target Neighborhood Hits	1052	Shared Neighborhood Hits	93
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YSK4_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.056841 (rank : 727)
Query Neighborhood Hits	485	Target Neighborhood Hits	921	Shared Neighborhood Hits	87
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.109954 (rank : 495)
Query Neighborhood Hits	485	Target Neighborhood Hits	893	Shared Neighborhood Hits	88
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 883)	NC score	0.110745 (rank : 487)
Query Neighborhood Hits	485	Target Neighborhood Hits	905	Shared Neighborhood Hits	88
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

PTPRD_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	485	Target Neighborhood Hits	485	Shared Neighborhood Hits	485
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
NC score	0.996969 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	485	Target Neighborhood Hits	491	Shared Neighborhood Hits	450
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRS_HUMAN
NC score	0.994339 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	485	Target Neighborhood Hits	472	Shared Neighborhood Hits	423
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRF_HUMAN
NC score	0.993287 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	485	Target Neighborhood Hits	489	Shared Neighborhood Hits	428
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRM_HUMAN
NC score	0.841256 (rank : 5)	θ value	6.18479e-142 (rank : 10)
Query Neighborhood Hits	485	Target Neighborhood Hits	244	Shared Neighborhood Hits	212
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
NC score	0.839763 (rank : 6)	θ value	3.62588e-142 (rank : 9)
Query Neighborhood Hits	485	Target Neighborhood Hits	238	Shared Neighborhood Hits	210
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRT_MOUSE
NC score	0.826303 (rank : 7)	θ value	1.86219e-138 (rank : 12)
Query Neighborhood Hits	485	Target Neighborhood Hits	219	Shared Neighborhood Hits	187
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRT_HUMAN
NC score	0.825687 (rank : 8)	θ value	4.58675e-137 (rank : 14)
Query Neighborhood Hits	485	Target Neighborhood Hits	217	Shared Neighborhood Hits	186
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRU_HUMAN
NC score	0.813929 (rank : 9)	θ value	8.97236e-125 (rank : 17)
Query Neighborhood Hits	485	Target Neighborhood Hits	237	Shared Neighborhood Hits	207
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRK_MOUSE
NC score	0.804169 (rank : 10)	θ value	1.20704e-137 (rank : 13)
Query Neighborhood Hits	485	Target Neighborhood Hits	223	Shared Neighborhood Hits	187
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_HUMAN
NC score	0.802653 (rank : 11)	θ value	5.78879e-140 (rank : 11)
Query Neighborhood Hits	485	Target Neighborhood Hits	228	Shared Neighborhood Hits	188
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRB_HUMAN
NC score	0.767012 (rank : 12)	θ value	1.04338e-64 (rank : 31)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	167
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRV_MOUSE
NC score	0.757144 (rank : 13)	θ value	5.91091e-68 (rank : 30)
Query Neighborhood Hits	485	Target Neighborhood Hits	179	Shared Neighborhood Hits	136
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRJ_HUMAN
NC score	0.753754 (rank : 14)	θ value	1.40689e-69 (rank : 28)
Query Neighborhood Hits	485	Target Neighborhood Hits	207	Shared Neighborhood Hits	159
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
NC score	0.753281 (rank : 15)	θ value	1.41016e-61 (rank : 32)
Query Neighborhood Hits	485	Target Neighborhood Hits	188	Shared Neighborhood Hits	152
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

NEO1_MOUSE
NC score	0.747332 (rank : 16)	θ value	1.27248e-70 (rank : 25)
Query Neighborhood Hits	485	Target Neighborhood Hits	523	Shared Neighborhood Hits	357
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NEO1_HUMAN
NC score	0.745764 (rank : 17)	θ value	5.71191e-71 (rank : 24)
Query Neighborhood Hits	485	Target Neighborhood Hits	530	Shared Neighborhood Hits	360
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

DCC_HUMAN
NC score	0.737436 (rank : 18)	θ value	1.66191e-70 (rank : 26)
Query Neighborhood Hits	485	Target Neighborhood Hits	583	Shared Neighborhood Hits	363
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

PTPRO_HUMAN
NC score	0.737048 (rank : 19)	θ value	3.25095e-58 (rank : 33)
Query Neighborhood Hits	485	Target Neighborhood Hits	139	Shared Neighborhood Hits	115
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

SDK2_MOUSE
NC score	0.736091 (rank : 20)	θ value	3.02872e-72 (rank : 23)
Query Neighborhood Hits	485	Target Neighborhood Hits	480	Shared Neighborhood Hits	358
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK1_MOUSE
NC score	0.734793 (rank : 21)	θ value	6.31527e-70 (rank : 27)
Query Neighborhood Hits	485	Target Neighborhood Hits	495	Shared Neighborhood Hits	366
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
NC score	0.733094 (rank : 22)	θ value	5.51964e-74 (rank : 22)
Query Neighborhood Hits	485	Target Neighborhood Hits	495	Shared Neighborhood Hits	365
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK1_HUMAN
NC score	0.731690 (rank : 23)	θ value	8.51556e-75 (rank : 21)
Query Neighborhood Hits	485	Target Neighborhood Hits	511	Shared Neighborhood Hits	367
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CD45_HUMAN
NC score	0.726996 (rank : 24)	θ value	2.80211e-110 (rank : 19)
Query Neighborhood Hits	485	Target Neighborhood Hits	243	Shared Neighborhood Hits	111
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
NC score	0.725689 (rank : 25)	θ value	1.48926e-103 (rank : 20)
Query Neighborhood Hits	485	Target Neighborhood Hits	178	Shared Neighborhood Hits	102
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

DCC_MOUSE
NC score	0.720234 (rank : 26)	θ value	3.4653e-68 (rank : 29)
Query Neighborhood Hits	485	Target Neighborhood Hits	896	Shared Neighborhood Hits	369
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

PTPRE_MOUSE
NC score	0.716057 (rank : 27)	θ value	8.88953e-157 (rank : 7)
Query Neighborhood Hits	485	Target Neighborhood Hits	86	Shared Neighborhood Hits	73
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_HUMAN
NC score	0.715837 (rank : 28)	θ value	1.98038e-156 (rank : 8)
Query Neighborhood Hits	485	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_HUMAN
NC score	0.715827 (rank : 29)	θ value	5.36813e-170 (rank : 5)
Query Neighborhood Hits	485	Target Neighborhood Hits	101	Shared Neighborhood Hits	74
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
NC score	0.715272 (rank : 30)	θ value	3.72618e-163 (rank : 6)
Query Neighborhood Hits	485	Target Neighborhood Hits	93	Shared Neighborhood Hits	74
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

DSCL1_HUMAN
NC score	0.711290 (rank : 31)	θ value	8.00737e-57 (rank : 34)
Query Neighborhood Hits	485	Target Neighborhood Hits	589	Shared Neighborhood Hits	354
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

NRCAM_HUMAN
NC score	0.705583 (rank : 32)	θ value	4.86918e-46 (rank : 50)
Query Neighborhood Hits	485	Target Neighborhood Hits	439	Shared Neighborhood Hits	343
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

DSCAM_HUMAN
NC score	0.705179 (rank : 33)	θ value	4.85792e-54 (rank : 35)
Query Neighborhood Hits	485	Target Neighborhood Hits	524	Shared Neighborhood Hits	350
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

NRCAM_MOUSE
NC score	0.703779 (rank : 34)	θ value	3.04986e-48 (rank : 44)
Query Neighborhood Hits	485	Target Neighborhood Hits	432	Shared Neighborhood Hits	337
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

L1CAM_HUMAN
NC score	0.701570 (rank : 35)	θ value	9.50281e-42 (rank : 76)
Query Neighborhood Hits	485	Target Neighborhood Hits	457	Shared Neighborhood Hits	343
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
NC score	0.697104 (rank : 36)	θ value	9.83387e-39 (rank : 89)
Query Neighborhood Hits	485	Target Neighborhood Hits	457	Shared Neighborhood Hits	344
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NFASC_HUMAN
NC score	0.689148 (rank : 37)	θ value	4.55743e-44 (rank : 63)
Query Neighborhood Hits	485	Target Neighborhood Hits	497	Shared Neighborhood Hits	342
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

CNTN2_HUMAN
NC score	0.683762 (rank : 38)	θ value	1.04822e-48 (rank : 42)
Query Neighborhood Hits	485	Target Neighborhood Hits	440	Shared Neighborhood Hits	340
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN5_HUMAN
NC score	0.683329 (rank : 39)	θ value	2.85459e-46 (rank : 47)
Query Neighborhood Hits	485	Target Neighborhood Hits	446	Shared Neighborhood Hits	341
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CNTN2_MOUSE
NC score	0.682216 (rank : 40)	θ value	4.86918e-46 (rank : 49)
Query Neighborhood Hits	485	Target Neighborhood Hits	450	Shared Neighborhood Hits	340
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

PTN7_MOUSE
NC score	0.681207 (rank : 41)	θ value	1.85029e-45 (rank : 54)
Query Neighborhood Hits	485	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN7_HUMAN
NC score	0.680814 (rank : 42)	θ value	1.41672e-45 (rank : 53)
Query Neighborhood Hits	485	Target Neighborhood Hits	75	Shared Neighborhood Hits	67
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PUNC_HUMAN
NC score	0.679769 (rank : 43)	θ value	1.85459e-37 (rank : 92)
Query Neighborhood Hits	485	Target Neighborhood Hits	449	Shared Neighborhood Hits	318
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

CNTN3_HUMAN
NC score	0.678381 (rank : 44)	θ value	1.52067e-31 (rank : 99)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	345
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN5_MOUSE
NC score	0.678226 (rank : 45)	θ value	8.59492e-43 (rank : 70)
Query Neighborhood Hits	485	Target Neighborhood Hits	434	Shared Neighborhood Hits	333
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

PTN2_HUMAN
NC score	0.677220 (rank : 46)	θ value	2.04573e-44 (rank : 59)
Query Neighborhood Hits	485	Target Neighborhood Hits	92	Shared Neighborhood Hits	64
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
NC score	0.676591 (rank : 47)	θ value	1.56636e-44 (rank : 58)
Query Neighborhood Hits	485	Target Neighborhood Hits	107	Shared Neighborhood Hits	65
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

CNTN3_MOUSE
NC score	0.676269 (rank : 48)	θ value	5.21438e-40 (rank : 86)
Query Neighborhood Hits	485	Target Neighborhood Hits	447	Shared Neighborhood Hits	343
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

PTN5_MOUSE
NC score	0.676259 (rank : 49)	θ value	5.95217e-44 (rank : 64)
Query Neighborhood Hits	485	Target Neighborhood Hits	85	Shared Neighborhood Hits	71
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN1_MOUSE
NC score	0.676167 (rank : 50)	θ value	6.58091e-43 (rank : 69)
Query Neighborhood Hits	485	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN1_HUMAN
NC score	0.676130 (rank : 51)	θ value	1.01529e-43 (rank : 66)
Query Neighborhood Hits	485	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN5_HUMAN
NC score	0.676120 (rank : 52)	θ value	2.50074e-42 (rank : 72)
Query Neighborhood Hits	485	Target Neighborhood Hits	80	Shared Neighborhood Hits	73
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

NFASC_MOUSE
NC score	0.676029 (rank : 53)	θ value	3.06405e-32 (rank : 98)
Query Neighborhood Hits	485	Target Neighborhood Hits	475	Shared Neighborhood Hits	336
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

PTN18_HUMAN
NC score	0.673488 (rank : 54)	θ value	1.51715e-39 (rank : 87)
Query Neighborhood Hits	485	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
NC score	0.673176 (rank : 55)	θ value	8.32485e-38 (rank : 90)
Query Neighborhood Hits	485	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN9_MOUSE
NC score	0.672858 (rank : 56)	θ value	1.32293e-51 (rank : 37)
Query Neighborhood Hits	485	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_HUMAN
NC score	0.672378 (rank : 57)	θ value	1.01294e-51 (rank : 36)
Query Neighborhood Hits	485	Target Neighborhood Hits	79	Shared Neighborhood Hits	67
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

CHL1_HUMAN
NC score	0.672183 (rank : 58)	θ value	1.85459e-37 (rank : 91)
Query Neighborhood Hits	485	Target Neighborhood Hits	413	Shared Neighborhood Hits	320
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

PTN22_HUMAN
NC score	0.671685 (rank : 59)	θ value	2.85459e-46 (rank : 48)
Query Neighborhood Hits	485	Target Neighborhood Hits	109	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PUNC_MOUSE
NC score	0.670763 (rank : 60)	θ value	2.42216e-37 (rank : 93)
Query Neighborhood Hits	485	Target Neighborhood Hits	501	Shared Neighborhood Hits	315
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

CNTN1_MOUSE
NC score	0.670745 (rank : 61)	θ value	1.62093e-41 (rank : 80)
Query Neighborhood Hits	485	Target Neighborhood Hits	422	Shared Neighborhood Hits	325
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

PTPRR_HUMAN
NC score	0.670401 (rank : 62)	θ value	7.27602e-42 (rank : 75)
Query Neighborhood Hits	485	Target Neighborhood Hits	77	Shared Neighborhood Hits	67
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTN12_HUMAN
NC score	0.670304 (rank : 63)	θ value	9.50281e-42 (rank : 77)
Query Neighborhood Hits	485	Target Neighborhood Hits	102	Shared Neighborhood Hits	72
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTPRR_MOUSE
NC score	0.670167 (rank : 64)	θ value	1.62093e-41 (rank : 81)
Query Neighborhood Hits	485	Target Neighborhood Hits	84	Shared Neighborhood Hits	70
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

CNTN1_HUMAN
NC score	0.669649 (rank : 65)	θ value	7.27602e-42 (rank : 74)
Query Neighborhood Hits	485	Target Neighborhood Hits	431	Shared Neighborhood Hits	327
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

PTN12_MOUSE
NC score	0.669407 (rank : 66)	θ value	2.34062e-40 (rank : 84)
Query Neighborhood Hits	485	Target Neighborhood Hits	123	Shared Neighborhood Hits	71
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTPR2_HUMAN
NC score	0.669329 (rank : 67)	θ value	6.35935e-46 (rank : 52)
Query Neighborhood Hits	485	Target Neighborhood Hits	103	Shared Neighborhood Hits	69
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

ROBO2_HUMAN
NC score	0.668898 (rank : 68)	θ value	1.788e-48 (rank : 43)
Query Neighborhood Hits	485	Target Neighborhood Hits	479	Shared Neighborhood Hits	338
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
NC score	0.668897 (rank : 69)	θ value	1.51363e-47 (rank : 45)
Query Neighborhood Hits	485	Target Neighborhood Hits	504	Shared Neighborhood Hits	345
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

PTPR2_MOUSE
NC score	0.668494 (rank : 70)	θ value	1.97686e-47 (rank : 46)
Query Neighborhood Hits	485	Target Neighborhood Hits	120	Shared Neighborhood Hits	68
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

ROBO3_MOUSE
NC score	0.665879 (rank : 71)	θ value	7.52953e-39 (rank : 88)
Query Neighborhood Hits	485	Target Neighborhood Hits	524	Shared Neighborhood Hits	333
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

PTPRN_HUMAN
NC score	0.665174 (rank : 72)	θ value	9.18288e-45 (rank : 57)
Query Neighborhood Hits	485	Target Neighborhood Hits	156	Shared Neighborhood Hits	71
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTN22_MOUSE
NC score	0.664930 (rank : 73)	θ value	1.2411e-41 (rank : 79)
Query Neighborhood Hits	485	Target Neighborhood Hits	179	Shared Neighborhood Hits	69
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

ROBO3_HUMAN
NC score	0.664881 (rank : 74)	θ value	3.61106e-41 (rank : 82)
Query Neighborhood Hits	485	Target Neighborhood Hits	570	Shared Neighborhood Hits	337
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

CNTN6_HUMAN
NC score	0.664230 (rank : 75)	θ value	5.03882e-43 (rank : 67)
Query Neighborhood Hits	485	Target Neighborhood Hits	422	Shared Neighborhood Hits	320
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

PTPRN_MOUSE
NC score	0.663091 (rank : 76)	θ value	3.15612e-45 (rank : 55)
Query Neighborhood Hits	485	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

CNTN4_HUMAN
NC score	0.662197 (rank : 77)	θ value	1.52067e-31 (rank : 100)
Query Neighborhood Hits	485	Target Neighborhood Hits	449	Shared Neighborhood Hits	329
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_MOUSE
NC score	0.661817 (rank : 78)	θ value	1.37539e-32 (rank : 96)
Query Neighborhood Hits	485	Target Neighborhood Hits	445	Shared Neighborhood Hits	327
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CHL1_MOUSE
NC score	0.660035 (rank : 79)	θ value	2.42779e-29 (rank : 104)
Query Neighborhood Hits	485	Target Neighborhood Hits	402	Shared Neighborhood Hits	316
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

PTPRG_HUMAN
NC score	0.656299 (rank : 80)	θ value	2.69525e-129 (rank : 15)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	110
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

ROBO1_MOUSE
NC score	0.656153 (rank : 81)	θ value	7.77379e-44 (rank : 65)
Query Neighborhood Hits	485	Target Neighborhood Hits	559	Shared Neighborhood Hits	340
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

CNTN6_MOUSE
NC score	0.655924 (rank : 82)	θ value	4.55743e-44 (rank : 62)
Query Neighborhood Hits	485	Target Neighborhood Hits	429	Shared Neighborhood Hits	324
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

PTPRZ_HUMAN
NC score	0.654292 (rank : 83)	θ value	1.63895e-118 (rank : 18)
Query Neighborhood Hits	485	Target Neighborhood Hits	255	Shared Neighborhood Hits	91
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTPRG_MOUSE
NC score	0.653017 (rank : 84)	θ value	3.5201e-129 (rank : 16)
Query Neighborhood Hits	485	Target Neighborhood Hits	260	Shared Neighborhood Hits	107
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

ROBO1_HUMAN
NC score	0.650788 (rank : 85)	θ value	2.67181e-44 (rank : 60)
Query Neighborhood Hits	485	Target Neighborhood Hits	529	Shared Neighborhood Hits	332
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

PTN6_HUMAN
NC score	0.638463 (rank : 86)	θ value	1.23823e-49 (rank : 39)
Query Neighborhood Hits	485	Target Neighborhood Hits	234	Shared Neighborhood Hits	72
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
NC score	0.637205 (rank : 87)	θ value	3.84914e-51 (rank : 38)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

FNDC3_HUMAN
NC score	0.633554 (rank : 88)	θ value	5.77852e-31 (rank : 101)
Query Neighborhood Hits	485	Target Neighborhood Hits	196	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
NC score	0.629643 (rank : 89)	θ value	1.6813e-30 (rank : 102)
Query Neighborhood Hits	485	Target Neighborhood Hits	207	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

BOC_HUMAN
NC score	0.625902 (rank : 90)	θ value	1.09232e-21 (rank : 124)
Query Neighborhood Hits	485	Target Neighborhood Hits	543	Shared Neighborhood Hits	311
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CDON_HUMAN
NC score	0.624111 (rank : 91)	θ value	1.24977e-17 (rank : 145)
Query Neighborhood Hits	485	Target Neighborhood Hits	412	Shared Neighborhood Hits	305
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

PTN11_MOUSE
NC score	0.622919 (rank : 92)	θ value	8.02596e-49 (rank : 41)
Query Neighborhood Hits	485	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.622914 (rank : 93)	θ value	8.02596e-49 (rank : 40)
Query Neighborhood Hits	485	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

CDON_MOUSE
NC score	0.621585 (rank : 94)	θ value	7.32683e-18 (rank : 144)
Query Neighborhood Hits	485	Target Neighborhood Hits	410	Shared Neighborhood Hits	304
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

BOC_MOUSE
NC score	0.618052 (rank : 95)	θ value	5.99374e-20 (rank : 130)
Query Neighborhood Hits	485	Target Neighborhood Hits	433	Shared Neighborhood Hits	302
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCAM2_MOUSE
NC score	0.616908 (rank : 96)	θ value	4.9032e-22 (rank : 121)
Query Neighborhood Hits	485	Target Neighborhood Hits	472	Shared Neighborhood Hits	331
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

MYOM1_HUMAN
NC score	0.616524 (rank : 97)	θ value	4.01107e-24 (rank : 115)
Query Neighborhood Hits	485	Target Neighborhood Hits	405	Shared Neighborhood Hits	300
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
NC score	0.610716 (rank : 98)	θ value	7.82807e-20 (rank : 133)
Query Neighborhood Hits	485	Target Neighborhood Hits	415	Shared Neighborhood Hits	319
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM2_HUMAN
NC score	0.608944 (rank : 99)	θ value	5.25075e-16 (rank : 153)
Query Neighborhood Hits	485	Target Neighborhood Hits	341	Shared Neighborhood Hits	291
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

NCAM2_HUMAN
NC score	0.603676 (rank : 100)	θ value	5.99374e-20 (rank : 131)
Query Neighborhood Hits	485	Target Neighborhood Hits	441	Shared Neighborhood Hits	325
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCA11_HUMAN
NC score	0.593642 (rank : 101)	θ value	6.40375e-22 (rank : 123)
Query Neighborhood Hits	485	Target Neighborhood Hits	443	Shared Neighborhood Hits	312
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

ROBO4_HUMAN
NC score	0.588710 (rank : 102)	θ value	8.95645e-16 (rank : 155)
Query Neighborhood Hits	485	Target Neighborhood Hits	364	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

NCA12_MOUSE
NC score	0.585801 (rank : 103)	θ value	1.2077e-20 (rank : 129)
Query Neighborhood Hits	485	Target Neighborhood Hits	399	Shared Neighborhood Hits	295
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

ROBO4_MOUSE
NC score	0.585467 (rank : 104)	θ value	1.74391e-19 (rank : 136)
Query Neighborhood Hits	485	Target Neighborhood Hits	358	Shared Neighborhood Hits	250
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

NCA12_HUMAN
NC score	0.583523 (rank : 105)	θ value	5.07402e-19 (rank : 138)
Query Neighborhood Hits	485	Target Neighborhood Hits	437	Shared Neighborhood Hits	307
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA11_MOUSE
NC score	0.579957 (rank : 106)	θ value	1.09232e-21 (rank : 125)
Query Neighborhood Hits	485	Target Neighborhood Hits	661	Shared Neighborhood Hits	313
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

OBSL1_HUMAN
NC score	0.573138 (rank : 107)	θ value	8.10077e-17 (rank : 151)
Query Neighborhood Hits	485	Target Neighborhood Hits	354	Shared Neighborhood Hits	251
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

PTN23_MOUSE
NC score	0.572219 (rank : 108)	θ value	1.2049e-28 (rank : 107)
Query Neighborhood Hits	485	Target Neighborhood Hits	726	Shared Neighborhood Hits	79
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN23_HUMAN
NC score	0.571106 (rank : 109)	θ value	7.06379e-29 (rank : 106)
Query Neighborhood Hits	485	Target Neighborhood Hits	646	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN14_HUMAN
NC score	0.567218 (rank : 110)	θ value	1.2411e-41 (rank : 78)
Query Neighborhood Hits	485	Target Neighborhood Hits	163	Shared Neighborhood Hits	74
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

FGRL1_HUMAN
NC score	0.565726 (rank : 111)	θ value	1.80466e-16 (rank : 152)
Query Neighborhood Hits	485	Target Neighborhood Hits	335	Shared Neighborhood Hits	249
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

FGRL1_MOUSE
NC score	0.565211 (rank : 112)	θ value	1.99529e-15 (rank : 158)
Query Neighborhood Hits	485	Target Neighborhood Hits	325	Shared Neighborhood Hits	252
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

FINC_MOUSE
NC score	0.564323 (rank : 113)	θ value	2.34606e-32 (rank : 97)
Query Neighborhood Hits	485	Target Neighborhood Hits	309	Shared Neighborhood Hits	181
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

PTN14_MOUSE
NC score	0.563017 (rank : 114)	θ value	6.15952e-41 (rank : 83)
Query Neighborhood Hits	485	Target Neighborhood Hits	142	Shared Neighborhood Hits	70
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

FINC_HUMAN
NC score	0.560455 (rank : 115)	θ value	5.584e-34 (rank : 95)
Query Neighborhood Hits	485	Target Neighborhood Hits	302	Shared Neighborhood Hits	192
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

PTN21_HUMAN
NC score	0.557941 (rank : 116)	θ value	1.91475e-42 (rank : 71)
Query Neighborhood Hits	485	Target Neighborhood Hits	143	Shared Neighborhood Hits	67
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

MYOTI_MOUSE
NC score	0.557792 (rank : 117)	θ value	2.13673e-09 (rank : 194)
Query Neighborhood Hits	485	Target Neighborhood Hits	297	Shared Neighborhood Hits	236
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPN_HUMAN
NC score	0.557488 (rank : 118)	θ value	1.2105e-12 (rank : 169)
Query Neighborhood Hits	485	Target Neighborhood Hits	418	Shared Neighborhood Hits	255
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

PTN21_MOUSE
NC score	0.557376 (rank : 119)	θ value	5.03882e-43 (rank : 68)
Query Neighborhood Hits	485	Target Neighborhood Hits	155	Shared Neighborhood Hits	68
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

MYOTI_HUMAN
NC score	0.556341 (rank : 120)	θ value	1.06045e-08 (rank : 201)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MAMC1_MOUSE
NC score	0.551045 (rank : 121)	θ value	1.33837e-11 (rank : 174)
Query Neighborhood Hits	485	Target Neighborhood Hits	357	Shared Neighborhood Hits	251
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_HUMAN
NC score	0.550400 (rank : 122)	θ value	6.64225e-11 (rank : 181)
Query Neighborhood Hits	485	Target Neighborhood Hits	357	Shared Neighborhood Hits	249
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYPN_MOUSE
NC score	0.547343 (rank : 123)	θ value	1.47974e-10 (rank : 182)
Query Neighborhood Hits	485	Target Neighborhood Hits	421	Shared Neighborhood Hits	249
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

MDGA1_HUMAN
NC score	0.545764 (rank : 124)	θ value	9.92553e-07 (rank : 241)
Query Neighborhood Hits	485	Target Neighborhood Hits	358	Shared Neighborhood Hits	254
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

NPHN_HUMAN
NC score	0.536342 (rank : 125)	θ value	1.69304e-06 (rank : 244)
Query Neighborhood Hits	485	Target Neighborhood Hits	362	Shared Neighborhood Hits	274
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

PTN3_HUMAN
NC score	0.534820 (rank : 126)	θ value	5.57106e-42 (rank : 73)
Query Neighborhood Hits	485	Target Neighborhood Hits	258	Shared Neighborhood Hits	78
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

NPHN_MOUSE
NC score	0.525712 (rank : 127)	θ value	3.08544e-08 (rank : 211)
Query Neighborhood Hits	485	Target Neighborhood Hits	370	Shared Neighborhood Hits	279
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

MYPC2_MOUSE
NC score	0.523279 (rank : 128)	θ value	8.38298e-14 (rank : 168)
Query Neighborhood Hits	485	Target Neighborhood Hits	297	Shared Neighborhood Hits	255
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

PTN4_HUMAN
NC score	0.518143 (rank : 129)	θ value	6.35935e-46 (rank : 51)
Query Neighborhood Hits	485	Target Neighborhood Hits	303	Shared Neighborhood Hits	77
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

MYPC2_HUMAN
NC score	0.517748 (rank : 130)	θ value	2.98157e-11 (rank : 178)
Query Neighborhood Hits	485	Target Neighborhood Hits	316	Shared Neighborhood Hits	269
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

LSAMP_MOUSE
NC score	0.515564 (rank : 131)	θ value	3.64472e-09 (rank : 198)
Query Neighborhood Hits	485	Target Neighborhood Hits	344	Shared Neighborhood Hits	251
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

LSAMP_HUMAN
NC score	0.514494 (rank : 132)	θ value	1.63604e-09 (rank : 193)
Query Neighborhood Hits	485	Target Neighborhood Hits	347	Shared Neighborhood Hits	252
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYPC3_HUMAN
NC score	0.511769 (rank : 133)	θ value	7.34386e-10 (rank : 188)
Query Neighborhood Hits	485	Target Neighborhood Hits	318	Shared Neighborhood Hits	266
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC1_HUMAN
NC score	0.508591 (rank : 134)	θ value	4.30538e-10 (rank : 187)
Query Neighborhood Hits	485	Target Neighborhood Hits	303	Shared Neighborhood Hits	264
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

NEGR1_HUMAN
NC score	0.505572 (rank : 135)	θ value	2.36244e-08 (rank : 208)
Query Neighborhood Hits	485	Target Neighborhood Hits	346	Shared Neighborhood Hits	245
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

PTN13_MOUSE
NC score	0.505158 (rank : 136)	θ value	3.48949e-44 (rank : 61)
Query Neighborhood Hits	485	Target Neighborhood Hits	426	Shared Neighborhood Hits	77
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

MYPC3_MOUSE
NC score	0.505125 (rank : 137)	θ value	2.13673e-09 (rank : 195)
Query Neighborhood Hits	485	Target Neighborhood Hits	310	Shared Neighborhood Hits	263
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

OPCM_HUMAN
NC score	0.504404 (rank : 138)	θ value	7.59969e-07 (rank : 238)
Query Neighborhood Hits	485	Target Neighborhood Hits	332	Shared Neighborhood Hits	251
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

NEGR1_MOUSE
NC score	0.503159 (rank : 139)	θ value	1.99992e-07 (rank : 230)
Query Neighborhood Hits	485	Target Neighborhood Hits	349	Shared Neighborhood Hits	247
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NTRI_MOUSE
NC score	0.501133 (rank : 140)	θ value	4.0297e-08 (rank : 214)
Query Neighborhood Hits	485	Target Neighborhood Hits	342	Shared Neighborhood Hits	254
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

PTN13_HUMAN
NC score	0.500767 (rank : 141)	θ value	9.18288e-45 (rank : 56)
Query Neighborhood Hits	485	Target Neighborhood Hits	471	Shared Neighborhood Hits	74
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

NTRI_HUMAN
NC score	0.497920 (rank : 142)	θ value	1.17247e-07 (rank : 224)
Query Neighborhood Hits	485	Target Neighborhood Hits	344	Shared Neighborhood Hits	255
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

MALT1_HUMAN
NC score	0.489041 (rank : 143)	θ value	2.36244e-08 (rank : 207)
Query Neighborhood Hits	485	Target Neighborhood Hits	236	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

MAG_MOUSE
NC score	0.478070 (rank : 144)	θ value	4.30538e-10 (rank : 186)
Query Neighborhood Hits	485	Target Neighborhood Hits	271	Shared Neighborhood Hits	227
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_HUMAN
NC score	0.477772 (rank : 145)	θ value	4.30538e-10 (rank : 185)
Query Neighborhood Hits	485	Target Neighborhood Hits	278	Shared Neighborhood Hits	226
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

VCAM1_MOUSE
NC score	0.475982 (rank : 146)	θ value	4.1701e-05 (rank : 274)
Query Neighborhood Hits	485	Target Neighborhood Hits	320	Shared Neighborhood Hits	228
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

VCAM1_HUMAN
NC score	0.468490 (rank : 147)	θ value	7.1131e-05 (rank : 280)
Query Neighborhood Hits	485	Target Neighborhood Hits	352	Shared Neighborhood Hits	225
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

FSTL5_HUMAN
NC score	0.463661 (rank : 148)	θ value	3.77169e-06 (rank : 249)
Query Neighborhood Hits	485	Target Neighborhood Hits	347	Shared Neighborhood Hits	239
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL4_HUMAN
NC score	0.462310 (rank : 149)	θ value	1.99992e-07 (rank : 229)
Query Neighborhood Hits	485	Target Neighborhood Hits	344	Shared Neighborhood Hits	241
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL5_MOUSE
NC score	0.460873 (rank : 150)	θ value	5.26297e-08 (rank : 218)
Query Neighborhood Hits	485	Target Neighborhood Hits	355	Shared Neighborhood Hits	235
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

TMIGD_HUMAN
NC score	0.458572 (rank : 151)	θ value	0.000121331 (rank : 285)
Query Neighborhood Hits	485	Target Neighborhood Hits	240	Shared Neighborhood Hits	201
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

FSTL4_MOUSE
NC score	0.457901 (rank : 152)	θ value	4.45536e-07 (rank : 232)
Query Neighborhood Hits	485	Target Neighborhood Hits	333	Shared Neighborhood Hits	236
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

KIRR2_HUMAN
NC score	0.456159 (rank : 153)	θ value	8.97725e-08 (rank : 222)
Query Neighborhood Hits	485	Target Neighborhood Hits	321	Shared Neighborhood Hits	216
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

LU_HUMAN
NC score	0.455031 (rank : 154)	θ value	0.0148317 (rank : 342)
Query Neighborhood Hits	485	Target Neighborhood Hits	283	Shared Neighborhood Hits	215
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

RAGE_HUMAN
NC score	0.450329 (rank : 155)	θ value	0.000461057 (rank : 302)
Query Neighborhood Hits	485	Target Neighborhood Hits	269	Shared Neighborhood Hits	212
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

KIRR2_MOUSE
NC score	0.449714 (rank : 156)	θ value	2.44474e-05 (rank : 268)
Query Neighborhood Hits	485	Target Neighborhood Hits	326	Shared Neighborhood Hits	216
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

JAM3_HUMAN
NC score	0.445878 (rank : 157)	θ value	4.0297e-08 (rank : 213)
Query Neighborhood Hits	485	Target Neighborhood Hits	271	Shared Neighborhood Hits	210
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

MYBPH_MOUSE
NC score	0.444529 (rank : 158)	θ value	2.88788e-06 (rank : 248)
Query Neighborhood Hits	485	Target Neighborhood Hits	290	Shared Neighborhood Hits	226
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

TMIGD_MOUSE
NC score	0.444248 (rank : 159)	θ value	0.000786445 (rank : 306)
Query Neighborhood Hits	485	Target Neighborhood Hits	234	Shared Neighborhood Hits	205
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

MUC18_HUMAN
NC score	0.441717 (rank : 160)	θ value	3.08544e-08 (rank : 210)
Query Neighborhood Hits	485	Target Neighborhood Hits	275	Shared Neighborhood Hits	199
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

JAM1_HUMAN
NC score	0.438871 (rank : 161)	θ value	7.59969e-07 (rank : 236)
Query Neighborhood Hits	485	Target Neighborhood Hits	294	Shared Neighborhood Hits	212
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

ICAM5_MOUSE
NC score	0.438013 (rank : 162)	θ value	4.92598e-06 (rank : 253)
Query Neighborhood Hits	485	Target Neighborhood Hits	308	Shared Neighborhood Hits	219
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

JAM3_MOUSE
NC score	0.437413 (rank : 163)	θ value	1.09739e-05 (rank : 261)
Query Neighborhood Hits	485	Target Neighborhood Hits	286	Shared Neighborhood Hits	211
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

NPTN_HUMAN
NC score	0.436642 (rank : 164)	θ value	0.00134147 (rank : 313)
Query Neighborhood Hits	485	Target Neighborhood Hits	212	Shared Neighborhood Hits	190
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

SN_MOUSE
NC score	0.435878 (rank : 165)	θ value	0.0431538 (rank : 360)
Query Neighborhood Hits	485	Target Neighborhood Hits	416	Shared Neighborhood Hits	248
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

COCA1_MOUSE
NC score	0.435624 (rank : 166)	θ value	1.33217e-27 (rank : 112)
Query Neighborhood Hits	485	Target Neighborhood Hits	467	Shared Neighborhood Hits	178
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

MYBPH_HUMAN
NC score	0.433621 (rank : 167)	θ value	7.59969e-07 (rank : 237)
Query Neighborhood Hits	485	Target Neighborhood Hits	256	Shared Neighborhood Hits	220
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

SN_HUMAN
NC score	0.431191 (rank : 168)	θ value	0.0148317 (rank : 344)
Query Neighborhood Hits	485	Target Neighborhood Hits	434	Shared Neighborhood Hits	245
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

CD22_MOUSE
NC score	0.430775 (rank : 169)	θ value	1.87187e-05 (rank : 264)
Query Neighborhood Hits	485	Target Neighborhood Hits	331	Shared Neighborhood Hits	204
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

RAGE_MOUSE
NC score	0.429453 (rank : 170)	θ value	0.00102713 (rank : 307)
Query Neighborhood Hits	485	Target Neighborhood Hits	295	Shared Neighborhood Hits	196
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

NPTN_MOUSE
NC score	0.428392 (rank : 171)	θ value	0.000270298 (rank : 293)
Query Neighborhood Hits	485	Target Neighborhood Hits	216	Shared Neighborhood Hits	187
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

MUC18_MOUSE
NC score	0.427648 (rank : 172)	θ value	0.000121331 (rank : 283)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	201
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

ICAM5_HUMAN
NC score	0.427120 (rank : 173)	θ value	1.09739e-05 (rank : 260)
Query Neighborhood Hits	485	Target Neighborhood Hits	276	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

COCA1_HUMAN
NC score	0.423023 (rank : 174)	θ value	3.17079e-29 (rank : 105)
Query Neighborhood Hits	485	Target Neighborhood Hits	458	Shared Neighborhood Hits	169
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

PGBM_HUMAN
NC score	0.421832 (rank : 175)	θ value	4.74913e-17 (rank : 149)
Query Neighborhood Hits	485	Target Neighborhood Hits	1113	Shared Neighborhood Hits	304
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CD22_HUMAN
NC score	0.420303 (rank : 176)	θ value	0.00134147 (rank : 309)
Query Neighborhood Hits	485	Target Neighborhood Hits	365	Shared Neighborhood Hits	218
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

TITIN_HUMAN
NC score	0.419731 (rank : 177)	θ value	3.05695e-40 (rank : 85)
Query Neighborhood Hits	485	Target Neighborhood Hits	2923	Shared Neighborhood Hits	400
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

HMCN1_HUMAN
NC score	0.419554 (rank : 178)	θ value	1.5242e-23 (rank : 116)
Query Neighborhood Hits	485	Target Neighborhood Hits	983	Shared Neighborhood Hits	299
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

JAM1_MOUSE
NC score	0.419010 (rank : 179)	θ value	4.92598e-06 (rank : 254)
Query Neighborhood Hits	485	Target Neighborhood Hits	287	Shared Neighborhood Hits	201
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

KAZD1_MOUSE
NC score	0.416867 (rank : 180)	θ value	7.1131e-05 (rank : 279)
Query Neighborhood Hits	485	Target Neighborhood Hits	281	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

PGBM_MOUSE
NC score	0.414945 (rank : 181)	θ value	1.24977e-17 (rank : 146)
Query Neighborhood Hits	485	Target Neighborhood Hits	1073	Shared Neighborhood Hits	297
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

KIRR3_HUMAN
NC score	0.414534 (rank : 182)	θ value	0.00035302 (rank : 298)
Query Neighborhood Hits	485	Target Neighborhood Hits	302	Shared Neighborhood Hits	214
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

LRIG2_HUMAN
NC score	0.414155 (rank : 183)	θ value	8.95645e-16 (rank : 154)
Query Neighborhood Hits	485	Target Neighborhood Hits	595	Shared Neighborhood Hits	265
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

JAM2_HUMAN
NC score	0.413823 (rank : 184)	θ value	5.44631e-05 (rank : 276)
Query Neighborhood Hits	485	Target Neighborhood Hits	304	Shared Neighborhood Hits	229
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

LRIG1_HUMAN
NC score	0.413496 (rank : 185)	θ value	2.5182e-18 (rank : 139)
Query Neighborhood Hits	485	Target Neighborhood Hits	654	Shared Neighborhood Hits	267
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

LRIG2_MOUSE
NC score	0.412642 (rank : 186)	θ value	3.40345e-15 (rank : 160)
Query Neighborhood Hits	485	Target Neighborhood Hits	586	Shared Neighborhood Hits	267
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

IL6RB_HUMAN
NC score	0.411910 (rank : 187)	θ value	5.8054e-15 (rank : 161)
Query Neighborhood Hits	485	Target Neighborhood Hits	181	Shared Neighborhood Hits	137
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

KIRR1_HUMAN
NC score	0.410493 (rank : 188)	θ value	0.00134147 (rank : 312)
Query Neighborhood Hits	485	Target Neighborhood Hits	401	Shared Neighborhood Hits	224
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KIRR3_MOUSE
NC score	0.409697 (rank : 189)	θ value	0.00298849 (rank : 319)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	210
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

CI094_HUMAN
NC score	0.408405 (rank : 190)	θ value	8.97725e-08 (rank : 220)
Query Neighborhood Hits	485	Target Neighborhood Hits	310	Shared Neighborhood Hits	218
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

LRIG1_MOUSE
NC score	0.407341 (rank : 191)	θ value	3.63628e-17 (rank : 147)
Query Neighborhood Hits	485	Target Neighborhood Hits	627	Shared Neighborhood Hits	267
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

KIRR1_MOUSE
NC score	0.406631 (rank : 192)	θ value	0.00390308 (rank : 321)
Query Neighborhood Hits	485	Target Neighborhood Hits	403	Shared Neighborhood Hits	222
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

USH2A_HUMAN
NC score	0.405558 (rank : 193)	θ value	1.01765e-35 (rank : 94)
Query Neighborhood Hits	485	Target Neighborhood Hits	600	Shared Neighborhood Hits	195
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

LRIG3_MOUSE
NC score	0.399509 (rank : 194)	θ value	5.60996e-18 (rank : 143)
Query Neighborhood Hits	485	Target Neighborhood Hits	611	Shared Neighborhood Hits	270
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

KAZD1_HUMAN
NC score	0.397265 (rank : 195)	θ value	1.09739e-05 (rank : 262)
Query Neighborhood Hits	485	Target Neighborhood Hits	248	Shared Neighborhood Hits	160
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

JAM2_MOUSE
NC score	0.396117 (rank : 196)	θ value	0.00134147 (rank : 311)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

LRIG3_HUMAN
NC score	0.395981 (rank : 197)	θ value	3.28887e-18 (rank : 141)
Query Neighborhood Hits	485	Target Neighborhood Hits	601	Shared Neighborhood Hits	269
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

USH2A_MOUSE
NC score	0.392195 (rank : 198)	θ value	4.57862e-28 (rank : 108)
Query Neighborhood Hits	485	Target Neighborhood Hits	626	Shared Neighborhood Hits	185
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

BASI_HUMAN
NC score	0.388284 (rank : 199)	θ value	0.0148317 (rank : 336)
Query Neighborhood Hits	485	Target Neighborhood Hits	211	Shared Neighborhood Hits	180
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

MFA3L_HUMAN
NC score	0.382523 (rank : 200)	θ value	0.00665767 (rank : 328)
Query Neighborhood Hits	485	Target Neighborhood Hits	230	Shared Neighborhood Hits	199
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

SIG11_HUMAN
NC score	0.381176 (rank : 201)	θ value	5.44631e-05 (rank : 277)
Query Neighborhood Hits	485	Target Neighborhood Hits	273	Shared Neighborhood Hits	213
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

CEAM5_HUMAN
NC score	0.380532 (rank : 202)	θ value	0.00869519 (rank : 331)
Query Neighborhood Hits	485	Target Neighborhood Hits	343	Shared Neighborhood Hits	222
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

ITB4_HUMAN
NC score	0.378691 (rank : 203)	θ value	1.42661e-21 (rank : 126)
Query Neighborhood Hits	485	Target Neighborhood Hits	458	Shared Neighborhood Hits	167
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

VSIG2_HUMAN
NC score	0.378430 (rank : 204)	θ value	0.47712 (rank : 398)
Query Neighborhood Hits	485	Target Neighborhood Hits	321	Shared Neighborhood Hits	212
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

BASI_MOUSE
NC score	0.377816 (rank : 205)	θ value	0.0252991 (rank : 352)
Query Neighborhood Hits	485	Target Neighborhood Hits	238	Shared Neighborhood Hits	182
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

IGS4B_MOUSE
NC score	0.374615 (rank : 206)	θ value	1.81305 (rank : 428)
Query Neighborhood Hits	485	Target Neighborhood Hits	328	Shared Neighborhood Hits	214
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

SIG10_HUMAN
NC score	0.374201 (rank : 207)	θ value	1.43324e-05 (rank : 263)
Query Neighborhood Hits	485	Target Neighborhood Hits	363	Shared Neighborhood Hits	212
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

TENN_MOUSE
NC score	0.374107 (rank : 208)	θ value	4.89182e-30 (rank : 103)
Query Neighborhood Hits	485	Target Neighborhood Hits	484	Shared Neighborhood Hits	160
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

NRG2_HUMAN
NC score	0.372703 (rank : 209)	θ value	0.000270298 (rank : 294)
Query Neighborhood Hits	485	Target Neighborhood Hits	419	Shared Neighborhood Hits	221
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

IBP7_HUMAN
NC score	0.371795 (rank : 210)	θ value	0.000121331 (rank : 282)
Query Neighborhood Hits	485	Target Neighborhood Hits	220	Shared Neighborhood Hits	163
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

CEAM1_MOUSE
NC score	0.371650 (rank : 211)	θ value	0.0736092 (rank : 362)
Query Neighborhood Hits	485	Target Neighborhood Hits	326	Shared Neighborhood Hits	220
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

COEA1_MOUSE
NC score	0.369557 (rank : 212)	θ value	6.18819e-25 (rank : 114)
Query Neighborhood Hits	485	Target Neighborhood Hits	402	Shared Neighborhood Hits	116
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

VSIG2_MOUSE
NC score	0.368019 (rank : 213)	θ value	0.125558 (rank : 371)
Query Neighborhood Hits	485	Target Neighborhood Hits	316	Shared Neighborhood Hits	204
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

IL6RB_MOUSE
NC score	0.367875 (rank : 214)	θ value	6.00763e-12 (rank : 173)
Query Neighborhood Hits	485	Target Neighborhood Hits	168	Shared Neighborhood Hits	132
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

NRG2_MOUSE
NC score	0.367429 (rank : 215)	θ value	0.000121331 (rank : 284)
Query Neighborhood Hits	485	Target Neighborhood Hits	392	Shared Neighborhood Hits	222
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

FCRL5_HUMAN
NC score	0.365683 (rank : 216)	θ value	0.163984 (rank : 372)
Query Neighborhood Hits	485	Target Neighborhood Hits	267	Shared Neighborhood Hits	191
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

IGS4B_HUMAN
NC score	0.364341 (rank : 217)	θ value	0.813845 (rank : 405)
Query Neighborhood Hits	485	Target Neighborhood Hits	305	Shared Neighborhood Hits	207
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

PTK7_HUMAN
NC score	0.363598 (rank : 218)	θ value	4.91457e-14 (rank : 166)
Query Neighborhood Hits	485	Target Neighborhood Hits	1103	Shared Neighborhood Hits	297
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

LIFR_HUMAN
NC score	0.363358 (rank : 219)	θ value	2.98157e-11 (rank : 177)
Query Neighborhood Hits	485	Target Neighborhood Hits	130	Shared Neighborhood Hits	103
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

LIFR_MOUSE
NC score	0.363170 (rank : 220)	θ value	1.25267e-09 (rank : 191)
Query Neighborhood Hits	485	Target Neighborhood Hits	127	Shared Neighborhood Hits	100
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

FCRL2_HUMAN
NC score	0.363084 (rank : 221)	θ value	0.0563607 (rank : 361)
Query Neighborhood Hits	485	Target Neighborhood Hits	251	Shared Neighborhood Hits	174
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

IBP7_MOUSE
NC score	0.362195 (rank : 222)	θ value	0.000158464 (rank : 286)
Query Neighborhood Hits	485	Target Neighborhood Hits	230	Shared Neighborhood Hits	161
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

TENR_HUMAN
NC score	0.359835 (rank : 223)	θ value	1.02001e-27 (rank : 109)
Query Neighborhood Hits	485	Target Neighborhood Hits	526	Shared Neighborhood Hits	168
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

CEA20_HUMAN
NC score	0.353598 (rank : 224)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	485	Target Neighborhood Hits	251	Shared Neighborhood Hits	182
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

TENR_MOUSE
NC score	0.351393 (rank : 225)	θ value	1.02001e-27 (rank : 110)
Query Neighborhood Hits	485	Target Neighborhood Hits	531	Shared Neighborhood Hits	164
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

MUSK_MOUSE
NC score	0.348166 (rank : 226)	θ value	6.40375e-22 (rank : 122)
Query Neighborhood Hits	485	Target Neighborhood Hits	1057	Shared Neighborhood Hits	292
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MUSK_HUMAN
NC score	0.347583 (rank : 227)	θ value	1.86321e-21 (rank : 127)
Query Neighborhood Hits	485	Target Neighborhood Hits	1074	Shared Neighborhood Hits	294
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

I12R2_HUMAN
NC score	0.345361 (rank : 228)	θ value	1.25267e-09 (rank : 190)
Query Neighborhood Hits	485	Target Neighborhood Hits	163	Shared Neighborhood Hits	118
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

I12R2_MOUSE
NC score	0.344004 (rank : 229)	θ value	2.36244e-08 (rank : 206)
Query Neighborhood Hits	485	Target Neighborhood Hits	143	Shared Neighborhood Hits	119
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

CEAM1_HUMAN
NC score	0.339913 (rank : 230)	θ value	0.000602161 (rank : 303)
Query Neighborhood Hits	485	Target Neighborhood Hits	348	Shared Neighborhood Hits	203
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

TENN_HUMAN
NC score	0.339630 (rank : 231)	θ value	1.92365e-26 (rank : 113)
Query Neighborhood Hits	485	Target Neighborhood Hits	453	Shared Neighborhood Hits	143
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

COEA1_HUMAN
NC score	0.332658 (rank : 232)	θ value	2.87452e-22 (rank : 118)
Query Neighborhood Hits	485	Target Neighborhood Hits	427	Shared Neighborhood Hits	130
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

MFA3L_MOUSE
NC score	0.330537 (rank : 233)	θ value	0.0113563 (rank : 335)
Query Neighborhood Hits	485	Target Neighborhood Hits	214	Shared Neighborhood Hits	183
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

ATL3_HUMAN
NC score	0.314555 (rank : 234)	θ value	1.17247e-07 (rank : 223)
Query Neighborhood Hits	485	Target Neighborhood Hits	414	Shared Neighborhood Hits	235
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

VSIG4_HUMAN
NC score	0.313698 (rank : 235)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	485	Target Neighborhood Hits	236	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

COKA1_HUMAN
NC score	0.313138 (rank : 236)	θ value	3.76295e-14 (rank : 164)
Query Neighborhood Hits	485	Target Neighborhood Hits	403	Shared Neighborhood Hits	121
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

CD166_MOUSE
NC score	0.311664 (rank : 237)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	485	Target Neighborhood Hits	252	Shared Neighborhood Hits	176
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CO7A1_HUMAN
NC score	0.309424 (rank : 238)	θ value	1.33217e-27 (rank : 111)
Query Neighborhood Hits	485	Target Neighborhood Hits	807	Shared Neighborhood Hits	164
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

GPA33_MOUSE
NC score	0.306452 (rank : 239)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	485	Target Neighborhood Hits	294	Shared Neighborhood Hits	168
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

VGFR1_HUMAN
NC score	0.304449 (rank : 240)	θ value	7.59969e-07 (rank : 239)
Query Neighborhood Hits	485	Target Neighborhood Hits	1109	Shared Neighborhood Hits	290
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
NC score	0.302450 (rank : 241)	θ value	4.45536e-07 (rank : 233)
Query Neighborhood Hits	485	Target Neighborhood Hits	1118	Shared Neighborhood Hits	289
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

CSF3R_HUMAN
NC score	0.302177 (rank : 242)	θ value	4.92598e-06 (rank : 251)
Query Neighborhood Hits	485	Target Neighborhood Hits	140	Shared Neighborhood Hits	109
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

SIGL5_MOUSE
NC score	0.299855 (rank : 243)	θ value	0.00175202 (rank : 315)
Query Neighborhood Hits	485	Target Neighborhood Hits	271	Shared Neighborhood Hits	200
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

VGFR2_HUMAN
NC score	0.297182 (rank : 244)	θ value	2.69671e-12 (rank : 170)
Query Neighborhood Hits	485	Target Neighborhood Hits	1103	Shared Neighborhood Hits	289
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

CEAM6_HUMAN
NC score	0.296537 (rank : 245)	θ value	0.00298849 (rank : 318)
Query Neighborhood Hits	485	Target Neighborhood Hits	308	Shared Neighborhood Hits	204
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

KALM_HUMAN
NC score	0.293184 (rank : 246)	θ value	6.43352e-06 (rank : 257)
Query Neighborhood Hits	485	Target Neighborhood Hits	114	Shared Neighborhood Hits	81
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

VGFR2_MOUSE
NC score	0.292261 (rank : 247)	θ value	2.13673e-09 (rank : 196)
Query Neighborhood Hits	485	Target Neighborhood Hits	1089	Shared Neighborhood Hits	286
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

TYRO3_HUMAN
NC score	0.292048 (rank : 248)	θ value	1.6852e-22 (rank : 117)
Query Neighborhood Hits	485	Target Neighborhood Hits	995	Shared Neighborhood Hits	267
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

OBSCN_HUMAN
NC score	0.291832 (rank : 249)	θ value	5.99374e-20 (rank : 132)
Query Neighborhood Hits	485	Target Neighborhood Hits	1931	Shared Neighborhood Hits	342
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

TYRO3_MOUSE
NC score	0.290701 (rank : 250)	θ value	2.87452e-22 (rank : 119)
Query Neighborhood Hits	485	Target Neighborhood Hits	1007	Shared Neighborhood Hits	272
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

MYLK_HUMAN
NC score	0.288086 (rank : 251)	θ value	1.02238e-19 (rank : 135)
Query Neighborhood Hits	485	Target Neighborhood Hits	1328	Shared Neighborhood Hits	321
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

CD166_HUMAN
NC score	0.286618 (rank : 252)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	485	Target Neighborhood Hits	247	Shared Neighborhood Hits	172
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

MYLK_MOUSE
NC score	0.286336 (rank : 253)	θ value	4.9032e-22 (rank : 120)
Query Neighborhood Hits	485	Target Neighborhood Hits	1489	Shared Neighborhood Hits	323
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

TENA_HUMAN
NC score	0.284677 (rank : 254)	θ value	4.29542e-18 (rank : 142)
Query Neighborhood Hits	485	Target Neighborhood Hits	631	Shared Neighborhood Hits	162
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

GPA33_HUMAN
NC score	0.283814 (rank : 255)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	485	Target Neighborhood Hits	273	Shared Neighborhood Hits	164
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

CILP2_HUMAN
NC score	0.283129 (rank : 256)	θ value	0.00869519 (rank : 332)
Query Neighborhood Hits	485	Target Neighborhood Hits	307	Shared Neighborhood Hits	181
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

LRFN4_HUMAN
NC score	0.279797 (rank : 257)	θ value	3.77169e-06 (rank : 250)
Query Neighborhood Hits	485	Target Neighborhood Hits	462	Shared Neighborhood Hits	211
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

SPEG_MOUSE
NC score	0.277612 (rank : 258)	θ value	3.63628e-17 (rank : 148)
Query Neighborhood Hits	485	Target Neighborhood Hits	1959	Shared Neighborhood Hits	314
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

FGFR4_MOUSE
NC score	0.277436 (rank : 259)	θ value	1.63604e-09 (rank : 192)
Query Neighborhood Hits	485	Target Neighborhood Hits	1026	Shared Neighborhood Hits	276
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

SPEG_HUMAN
NC score	0.275871 (rank : 260)	θ value	8.95645e-16 (rank : 156)
Query Neighborhood Hits	485	Target Neighborhood Hits	1762	Shared Neighborhood Hits	310
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

LRFN4_MOUSE
NC score	0.274558 (rank : 261)	θ value	2.88788e-06 (rank : 246)
Query Neighborhood Hits	485	Target Neighborhood Hits	442	Shared Neighborhood Hits	202
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

FGFR4_HUMAN
NC score	0.271708 (rank : 262)	θ value	1.25267e-09 (rank : 189)
Query Neighborhood Hits	485	Target Neighborhood Hits	1037	Shared Neighborhood Hits	277
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

TENX_HUMAN
NC score	0.270547 (rank : 263)	θ value	7.82807e-20 (rank : 134)
Query Neighborhood Hits	485	Target Neighborhood Hits	789	Shared Neighborhood Hits	171
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

HCFC2_MOUSE
NC score	0.268788 (rank : 264)	θ value	0.00134147 (rank : 310)
Query Neighborhood Hits	485	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

FGFR3_MOUSE
NC score	0.268709 (rank : 265)	θ value	5.26297e-08 (rank : 217)
Query Neighborhood Hits	485	Target Neighborhood Hits	1059	Shared Neighborhood Hits	273
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

TENA_MOUSE
NC score	0.268692 (rank : 266)	θ value	6.20254e-17 (rank : 150)
Query Neighborhood Hits	485	Target Neighborhood Hits	596	Shared Neighborhood Hits	150
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

LRFN2_MOUSE
NC score	0.267056 (rank : 267)	θ value	0.000270298 (rank : 292)
Query Neighborhood Hits	485	Target Neighborhood Hits	450	Shared Neighborhood Hits	208
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN2_HUMAN
NC score	0.266646 (rank : 268)	θ value	0.000786445 (rank : 305)
Query Neighborhood Hits	485	Target Neighborhood Hits	450	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN3_MOUSE
NC score	0.266276 (rank : 269)	θ value	0.00035302 (rank : 299)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	209
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

MERTK_HUMAN
NC score	0.265786 (rank : 270)	θ value	7.0802e-21 (rank : 128)
Query Neighborhood Hits	485	Target Neighborhood Hits	988	Shared Neighborhood Hits	252
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

FGFR1_HUMAN
NC score	0.264790 (rank : 271)	θ value	1.80886e-08 (rank : 204)
Query Neighborhood Hits	485	Target Neighborhood Hits	1069	Shared Neighborhood Hits	275
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
NC score	0.264468 (rank : 272)	θ value	1.80886e-08 (rank : 205)
Query Neighborhood Hits	485	Target Neighborhood Hits	1068	Shared Neighborhood Hits	274
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR3_HUMAN
NC score	0.262211 (rank : 273)	θ value	6.87365e-08 (rank : 219)
Query Neighborhood Hits	485	Target Neighborhood Hits	1042	Shared Neighborhood Hits	270
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR2_HUMAN
NC score	0.260022 (rank : 274)	θ value	2.52405e-10 (rank : 184)
Query Neighborhood Hits	485	Target Neighborhood Hits	1062	Shared Neighborhood Hits	267
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

MERTK_MOUSE
NC score	0.259078 (rank : 275)	θ value	2.5182e-18 (rank : 140)
Query Neighborhood Hits	485	Target Neighborhood Hits	974	Shared Neighborhood Hits	244
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

IL1R2_HUMAN
NC score	0.258847 (rank : 276)	θ value	0.163984 (rank : 376)
Query Neighborhood Hits	485	Target Neighborhood Hits	153	Shared Neighborhood Hits	124
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

UFO_MOUSE
NC score	0.256516 (rank : 277)	θ value	1.74391e-19 (rank : 137)
Query Neighborhood Hits	485	Target Neighborhood Hits	988	Shared Neighborhood Hits	254
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

LRFN3_HUMAN
NC score	0.255099 (rank : 278)	θ value	0.000158464 (rank : 287)
Query Neighborhood Hits	485	Target Neighborhood Hits	444	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

UFO_HUMAN
NC score	0.253300 (rank : 279)	θ value	1.16975e-15 (rank : 157)
Query Neighborhood Hits	485	Target Neighborhood Hits	981	Shared Neighborhood Hits	248
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

VGFR3_HUMAN
NC score	0.251948 (rank : 280)	θ value	1.87187e-05 (rank : 266)
Query Neighborhood Hits	485	Target Neighborhood Hits	1037	Shared Neighborhood Hits	261
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR2_MOUSE
NC score	0.251500 (rank : 281)	θ value	1.38499e-08 (rank : 203)
Query Neighborhood Hits	485	Target Neighborhood Hits	1062	Shared Neighborhood Hits	263
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

CEAM8_HUMAN
NC score	0.251066 (rank : 282)	θ value	0.47712 (rank : 394)
Query Neighborhood Hits	485	Target Neighborhood Hits	264	Shared Neighborhood Hits	186
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

LRFN5_MOUSE
NC score	0.250666 (rank : 283)	θ value	1.29631e-06 (rank : 243)
Query Neighborhood Hits	485	Target Neighborhood Hits	472	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

VGFR3_MOUSE
NC score	0.250399 (rank : 284)	θ value	9.29e-05 (rank : 281)
Query Neighborhood Hits	485	Target Neighborhood Hits	1056	Shared Neighborhood Hits	268
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

UNC5D_MOUSE
NC score	0.250164 (rank : 285)	θ value	0.00102713 (rank : 308)
Query Neighborhood Hits	485	Target Neighborhood Hits	268	Shared Neighborhood Hits	171
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

SIGL5_HUMAN
NC score	0.249897 (rank : 286)	θ value	0.0193708 (rank : 351)
Query Neighborhood Hits	485	Target Neighborhood Hits	246	Shared Neighborhood Hits	171
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

NRG1_HUMAN
NC score	0.248599 (rank : 287)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	485	Target Neighborhood Hits	285	Shared Neighborhood Hits	152
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

LRC21_MOUSE
NC score	0.247537 (rank : 288)	θ value	0.0431538 (rank : 359)
Query Neighborhood Hits	485	Target Neighborhood Hits	462	Shared Neighborhood Hits	219
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

CSF3R_MOUSE
NC score	0.245284 (rank : 289)	θ value	4.1701e-05 (rank : 270)
Query Neighborhood Hits	485	Target Neighborhood Hits	104	Shared Neighborhood Hits	87
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

LRFN5_HUMAN
NC score	0.245192 (rank : 290)	θ value	2.88788e-06 (rank : 247)
Query Neighborhood Hits	485	Target Neighborhood Hits	464	Shared Neighborhood Hits	204
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

LRC21_HUMAN
NC score	0.245116 (rank : 291)	θ value	0.365318 (rank : 390)
Query Neighborhood Hits	485	Target Neighborhood Hits	456	Shared Neighborhood Hits	216
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

UNC5D_HUMAN
NC score	0.245017 (rank : 292)	θ value	0.00175202 (rank : 316)
Query Neighborhood Hits	485	Target Neighborhood Hits	267	Shared Neighborhood Hits	169
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

TIE1_MOUSE
NC score	0.241071 (rank : 293)	θ value	4.1701e-05 (rank : 273)
Query Neighborhood Hits	485	Target Neighborhood Hits	1266	Shared Neighborhood Hits	229
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHB6_HUMAN
NC score	0.239694 (rank : 294)	θ value	5.26297e-08 (rank : 216)
Query Neighborhood Hits	485	Target Neighborhood Hits	912	Shared Neighborhood Hits	184
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ROR2_MOUSE
NC score	0.238294 (rank : 295)	θ value	4.92598e-06 (rank : 255)
Query Neighborhood Hits	485	Target Neighborhood Hits	1000	Shared Neighborhood Hits	253
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

TARSH_HUMAN
NC score	0.237392 (rank : 296)	θ value	0.000270298 (rank : 295)
Query Neighborhood Hits	485	Target Neighborhood Hits	768	Shared Neighborhood Hits	120
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ESAM_HUMAN
NC score	0.237249 (rank : 297)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	485	Target Neighborhood Hits	251	Shared Neighborhood Hits	154
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

SIGL8_HUMAN
NC score	0.236590 (rank : 298)	θ value	1.38821 (rank : 419)
Query Neighborhood Hits	485	Target Neighborhood Hits	252	Shared Neighborhood Hits	194
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

PSG3_HUMAN
NC score	0.236040 (rank : 299)	θ value	6.88961 (rank : 463)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	178
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

EPHB6_MOUSE
NC score	0.234520 (rank : 300)	θ value	4.0297e-08 (rank : 212)
Query Neighborhood Hits	485	Target Neighborhood Hits	906	Shared Neighborhood Hits	176
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

TIE1_HUMAN
NC score	0.232235 (rank : 301)	θ value	4.0297e-08 (rank : 215)
Query Neighborhood Hits	485	Target Neighborhood Hits	1241	Shared Neighborhood Hits	215
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

PSG8_HUMAN
NC score	0.231194 (rank : 302)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	485	Target Neighborhood Hits	239	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

IRPL2_HUMAN
NC score	0.230773 (rank : 303)	θ value	0.0148317 (rank : 338)
Query Neighborhood Hits	485	Target Neighborhood Hits	194	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

CSF1R_MOUSE
NC score	0.230735 (rank : 304)	θ value	0.0252991 (rank : 353)
Query Neighborhood Hits	485	Target Neighborhood Hits	983	Shared Neighborhood Hits	229
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ROR2_HUMAN
NC score	0.230388 (rank : 305)	θ value	1.87187e-05 (rank : 265)
Query Neighborhood Hits	485	Target Neighborhood Hits	1014	Shared Neighborhood Hits	250
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

PSG4_HUMAN
NC score	0.230303 (rank : 306)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	485	Target Neighborhood Hits	243	Shared Neighborhood Hits	176
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

CILP1_MOUSE
NC score	0.230290 (rank : 307)	θ value	0.813845 (rank : 403)
Query Neighborhood Hits	485	Target Neighborhood Hits	282	Shared Neighborhood Hits	177
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

LRRN1_HUMAN
NC score	0.229492 (rank : 308)	θ value	0.0148317 (rank : 340)
Query Neighborhood Hits	485	Target Neighborhood Hits	518	Shared Neighborhood Hits	237
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

IRPL1_MOUSE
NC score	0.229403 (rank : 309)	θ value	0.00390308 (rank : 320)
Query Neighborhood Hits	485	Target Neighborhood Hits	186	Shared Neighborhood Hits	146
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

TIE2_MOUSE
NC score	0.228773 (rank : 310)	θ value	5.8054e-15 (rank : 162)
Query Neighborhood Hits	485	Target Neighborhood Hits	1204	Shared Neighborhood Hits	197
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

IRPL2_MOUSE
NC score	0.228770 (rank : 311)	θ value	0.0148317 (rank : 339)
Query Neighborhood Hits	485	Target Neighborhood Hits	195	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

EPHA7_HUMAN
NC score	0.228530 (rank : 312)	θ value	1.74796e-11 (rank : 175)
Query Neighborhood Hits	485	Target Neighborhood Hits	1053	Shared Neighborhood Hits	192
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
NC score	0.227561 (rank : 313)	θ value	6.64225e-11 (rank : 179)
Query Neighborhood Hits	485	Target Neighborhood Hits	1025	Shared Neighborhood Hits	189
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

TIE2_HUMAN
NC score	0.226116 (rank : 314)	θ value	2.60593e-15 (rank : 159)
Query Neighborhood Hits	485	Target Neighborhood Hits	1192	Shared Neighborhood Hits	197
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

DUS23_MOUSE
NC score	0.225178 (rank : 315)	θ value	0.125558 (rank : 370)
Query Neighborhood Hits	485	Target Neighborhood Hits	94	Shared Neighborhood Hits	62
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

SORL_HUMAN
NC score	0.224942 (rank : 316)	θ value	4.76016e-09 (rank : 199)
Query Neighborhood Hits	485	Target Neighborhood Hits	440	Shared Neighborhood Hits	137
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

LRRN3_HUMAN
NC score	0.224780 (rank : 317)	θ value	0.0113563 (rank : 334)
Query Neighborhood Hits	485	Target Neighborhood Hits	461	Shared Neighborhood Hits	210
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

CXAR_HUMAN
NC score	0.224460 (rank : 318)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	485	Target Neighborhood Hits	245	Shared Neighborhood Hits	139
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

EPHA8_MOUSE
NC score	0.224387 (rank : 319)	θ value	6.00763e-12 (rank : 172)
Query Neighborhood Hits	485	Target Neighborhood Hits	969	Shared Neighborhood Hits	195
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

PSG11_HUMAN
NC score	0.224214 (rank : 320)	θ value	6.88961 (rank : 462)
Query Neighborhood Hits	485	Target Neighborhood Hits	223	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG7_HUMAN
NC score	0.223544 (rank : 321)	θ value	8.99809 (rank : 480)
Query Neighborhood Hits	485	Target Neighborhood Hits	239	Shared Neighborhood Hits	175
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

EPHA3_MOUSE
NC score	0.222702 (rank : 322)	θ value	3.52202e-12 (rank : 171)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	197
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA8_HUMAN
NC score	0.222029 (rank : 323)	θ value	1.9326e-10 (rank : 183)
Query Neighborhood Hits	485	Target Neighborhood Hits	956	Shared Neighborhood Hits	193
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

SIG12_HUMAN
NC score	0.221941 (rank : 324)	θ value	0.365318 (rank : 391)
Query Neighborhood Hits	485	Target Neighborhood Hits	245	Shared Neighborhood Hits	197
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

EPHA4_MOUSE
NC score	0.221852 (rank : 325)	θ value	1.68911e-14 (rank : 163)
Query Neighborhood Hits	485	Target Neighborhood Hits	982	Shared Neighborhood Hits	187
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

ROR1_HUMAN
NC score	0.220925 (rank : 326)	θ value	2.44474e-05 (rank : 269)
Query Neighborhood Hits	485	Target Neighborhood Hits	1018	Shared Neighborhood Hits	245
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

SIGL6_HUMAN
NC score	0.220660 (rank : 327)	θ value	0.365318 (rank : 392)
Query Neighborhood Hits	485	Target Neighborhood Hits	233	Shared Neighborhood Hits	179
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

ESAM_MOUSE
NC score	0.220607 (rank : 328)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	485	Target Neighborhood Hits	222	Shared Neighborhood Hits	147
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

CILP1_HUMAN
NC score	0.220426 (rank : 329)	θ value	0.0961366 (rank : 366)
Query Neighborhood Hits	485	Target Neighborhood Hits	266	Shared Neighborhood Hits	164
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

NTRK2_HUMAN
NC score	0.220263 (rank : 330)	θ value	0.000158464 (rank : 288)
Query Neighborhood Hits	485	Target Neighborhood Hits	1081	Shared Neighborhood Hits	243
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

LRRN1_MOUSE
NC score	0.220262 (rank : 331)	θ value	0.0736092 (rank : 363)
Query Neighborhood Hits	485	Target Neighborhood Hits	508	Shared Neighborhood Hits	231
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

ROR1_MOUSE
NC score	0.220258 (rank : 332)	θ value	8.40245e-06 (rank : 259)
Query Neighborhood Hits	485	Target Neighborhood Hits	1025	Shared Neighborhood Hits	252
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

NTRK2_MOUSE
NC score	0.219752 (rank : 333)	θ value	0.00035302 (rank : 300)
Query Neighborhood Hits	485	Target Neighborhood Hits	1088	Shared Neighborhood Hits	246
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

EPHA4_HUMAN
NC score	0.219656 (rank : 334)	θ value	3.76295e-14 (rank : 165)
Query Neighborhood Hits	485	Target Neighborhood Hits	975	Shared Neighborhood Hits	184
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHB3_MOUSE
NC score	0.218959 (rank : 335)	θ value	3.08544e-08 (rank : 209)
Query Neighborhood Hits	485	Target Neighborhood Hits	996	Shared Neighborhood Hits	189
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

PSG2_HUMAN
NC score	0.218668 (rank : 336)	θ value	3.0926 (rank : 442)
Query Neighborhood Hits	485	Target Neighborhood Hits	229	Shared Neighborhood Hits	171
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

NTRK3_HUMAN
NC score	0.218454 (rank : 337)	θ value	0.0148317 (rank : 343)
Query Neighborhood Hits	485	Target Neighborhood Hits	1115	Shared Neighborhood Hits	243
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

EPHA3_HUMAN
NC score	0.217700 (rank : 338)	θ value	2.28291e-11 (rank : 176)
Query Neighborhood Hits	485	Target Neighborhood Hits	1005	Shared Neighborhood Hits	198
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

SORL_MOUSE
NC score	0.217494 (rank : 339)	θ value	8.11959e-09 (rank : 200)
Query Neighborhood Hits	485	Target Neighborhood Hits	439	Shared Neighborhood Hits	133
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

PSG1_HUMAN
NC score	0.217237 (rank : 340)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	485	Target Neighborhood Hits	232	Shared Neighborhood Hits	175
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

CD276_HUMAN
NC score	0.217027 (rank : 341)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	485	Target Neighborhood Hits	261	Shared Neighborhood Hits	134
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

EPHB3_HUMAN
NC score	0.216995 (rank : 342)	θ value	8.97725e-08 (rank : 221)
Query Neighborhood Hits	485	Target Neighborhood Hits	996	Shared Neighborhood Hits	187
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

CXAR_MOUSE
NC score	0.216597 (rank : 343)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	485	Target Neighborhood Hits	250	Shared Neighborhood Hits	140
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

PSG6_HUMAN
NC score	0.216090 (rank : 344)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	166
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

IRPL1_HUMAN
NC score	0.216008 (rank : 345)	θ value	0.0252991 (rank : 354)
Query Neighborhood Hits	485	Target Neighborhood Hits	196	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

PGFRA_HUMAN
NC score	0.214965 (rank : 346)	θ value	6.43352e-06 (rank : 258)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	226
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
NC score	0.214705 (rank : 347)	θ value	9.92553e-07 (rank : 242)
Query Neighborhood Hits	485	Target Neighborhood Hits	975	Shared Neighborhood Hits	226
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

EPHA5_HUMAN
NC score	0.213252 (rank : 348)	θ value	2.79066e-09 (rank : 197)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	196
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

IL1R2_MOUSE
NC score	0.213162 (rank : 349)	θ value	0.163984 (rank : 377)
Query Neighborhood Hits	485	Target Neighborhood Hits	125	Shared Neighborhood Hits	97
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

PSG10_HUMAN
NC score	0.212880 (rank : 350)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	485	Target Neighborhood Hits	227	Shared Neighborhood Hits	164
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

DUS23_HUMAN
NC score	0.211867 (rank : 351)	θ value	0.279714 (rank : 383)
Query Neighborhood Hits	485	Target Neighborhood Hits	98	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

LRRN3_MOUSE
NC score	0.211415 (rank : 352)	θ value	0.0148317 (rank : 341)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	205
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

EPHB4_MOUSE
NC score	0.211152 (rank : 353)	θ value	5.81887e-07 (rank : 234)
Query Neighborhood Hits	485	Target Neighborhood Hits	1013	Shared Neighborhood Hits	184
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

DUET_HUMAN
NC score	0.210334 (rank : 354)	θ value	8.38298e-14 (rank : 167)
Query Neighborhood Hits	485	Target Neighborhood Hits	1220	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

CRLF1_HUMAN
NC score	0.208866 (rank : 355)	θ value	0.0330416 (rank : 355)
Query Neighborhood Hits	485	Target Neighborhood Hits	122	Shared Neighborhood Hits	94
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

ROS_HUMAN
NC score	0.208652 (rank : 356)	θ value	1.17247e-07 (rank : 226)
Query Neighborhood Hits	485	Target Neighborhood Hits	907	Shared Neighborhood Hits	189
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

EPHB4_HUMAN
NC score	0.206082 (rank : 357)	θ value	9.92553e-07 (rank : 240)
Query Neighborhood Hits	485	Target Neighborhood Hits	1056	Shared Neighborhood Hits	188
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

UNC5C_HUMAN
NC score	0.205109 (rank : 358)	θ value	0.00665767 (rank : 329)
Query Neighborhood Hits	485	Target Neighborhood Hits	226	Shared Neighborhood Hits	123
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
NC score	0.205051 (rank : 359)	θ value	0.00665767 (rank : 330)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	126
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

KIT_MOUSE
NC score	0.205000 (rank : 360)	θ value	0.0961366 (rank : 369)
Query Neighborhood Hits	485	Target Neighborhood Hits	949	Shared Neighborhood Hits	210
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

PGFRB_MOUSE
NC score	0.204631 (rank : 361)	θ value	6.88961 (rank : 459)
Query Neighborhood Hits	485	Target Neighborhood Hits	960	Shared Neighborhood Hits	213
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

EPHB2_MOUSE
NC score	0.204409 (rank : 362)	θ value	1.99992e-07 (rank : 228)
Query Neighborhood Hits	485	Target Neighborhood Hits	982	Shared Neighborhood Hits	176
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.204391 (rank : 363)	θ value	1.99992e-07 (rank : 227)
Query Neighborhood Hits	485	Target Neighborhood Hits	983	Shared Neighborhood Hits	176
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

CRLF1_MOUSE
NC score	0.203105 (rank : 364)	θ value	0.0431538 (rank : 356)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

UNC5A_HUMAN
NC score	0.202826 (rank : 365)	θ value	1.38821 (rank : 422)
Query Neighborhood Hits	485	Target Neighborhood Hits	198	Shared Neighborhood Hits	118
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

EPHB1_HUMAN
NC score	0.202495 (rank : 366)	θ value	6.64225e-11 (rank : 180)
Query Neighborhood Hits	485	Target Neighborhood Hits	988	Shared Neighborhood Hits	177
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

LRRN5_HUMAN
NC score	0.202465 (rank : 367)	θ value	0.47712 (rank : 397)
Query Neighborhood Hits	485	Target Neighborhood Hits	493	Shared Neighborhood Hits	216
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

PSG9_HUMAN
NC score	0.201836 (rank : 368)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	485	Target Neighborhood Hits	221	Shared Neighborhood Hits	165
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

IGS21_HUMAN
NC score	0.201469 (rank : 369)	θ value	0.0193708 (rank : 348)
Query Neighborhood Hits	485	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

PSG5_HUMAN
NC score	0.201220 (rank : 370)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	168
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

EPHA6_HUMAN
NC score	0.201159 (rank : 371)	θ value	7.59969e-07 (rank : 235)
Query Neighborhood Hits	485	Target Neighborhood Hits	959	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

IGS21_MOUSE
NC score	0.198413 (rank : 372)	θ value	0.0193708 (rank : 349)
Query Neighborhood Hits	485	Target Neighborhood Hits	118	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

EPHA2_HUMAN
NC score	0.197727 (rank : 373)	θ value	4.92598e-06 (rank : 252)
Query Neighborhood Hits	485	Target Neighborhood Hits	1021	Shared Neighborhood Hits	174
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

UNC5B_HUMAN
NC score	0.197130 (rank : 374)	θ value	0.00509761 (rank : 325)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

KIT_HUMAN
NC score	0.196449 (rank : 375)	θ value	0.365318 (rank : 389)
Query Neighborhood Hits	485	Target Neighborhood Hits	953	Shared Neighborhood Hits	208
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

CSF1R_HUMAN
NC score	0.196019 (rank : 376)	θ value	0.0961366 (rank : 367)
Query Neighborhood Hits	485	Target Neighborhood Hits	943	Shared Neighborhood Hits	202
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

PGFRB_HUMAN
NC score	0.195488 (rank : 377)	θ value	5.27518 (rank : 452)
Query Neighborhood Hits	485	Target Neighborhood Hits	962	Shared Neighborhood Hits	212
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

UNC5B_MOUSE
NC score	0.193141 (rank : 378)	θ value	0.00509761 (rank : 326)
Query Neighborhood Hits	485	Target Neighborhood Hits	226	Shared Neighborhood Hits	128
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

EPHA6_MOUSE
NC score	0.192832 (rank : 379)	θ value	4.1701e-05 (rank : 272)
Query Neighborhood Hits	485	Target Neighborhood Hits	946	Shared Neighborhood Hits	156
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

PECA1_HUMAN
NC score	0.192426 (rank : 380)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	485	Target Neighborhood Hits	178	Shared Neighborhood Hits	128
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

EPHA5_MOUSE
NC score	0.192158 (rank : 381)	θ value	6.43352e-06 (rank : 256)
Query Neighborhood Hits	485	Target Neighborhood Hits	950	Shared Neighborhood Hits	184
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

I12R1_HUMAN
NC score	0.191716 (rank : 382)	θ value	7.1131e-05 (rank : 278)
Query Neighborhood Hits	485	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

EPHA2_MOUSE
NC score	0.190764 (rank : 383)	θ value	4.1701e-05 (rank : 271)
Query Neighborhood Hits	485	Target Neighborhood Hits	1020	Shared Neighborhood Hits	168
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHAA_HUMAN
NC score	0.189168 (rank : 384)	θ value	0.00020696 (rank : 289)
Query Neighborhood Hits	485	Target Neighborhood Hits	960	Shared Neighborhood Hits	156
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

PVRL3_MOUSE
NC score	0.188454 (rank : 385)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	485	Target Neighborhood Hits	212	Shared Neighborhood Hits	129
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

PGFRL_HUMAN
NC score	0.187426 (rank : 386)	θ value	1.38821 (rank : 418)
Query Neighborhood Hits	485	Target Neighborhood Hits	115	Shared Neighborhood Hits	107
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

LRC24_HUMAN
NC score	0.187340 (rank : 387)	θ value	0.163984 (rank : 378)
Query Neighborhood Hits	485	Target Neighborhood Hits	404	Shared Neighborhood Hits	180
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

IL1R1_HUMAN
NC score	0.182264 (rank : 388)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	485	Target Neighborhood Hits	140	Shared Neighborhood Hits	118
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

MOX2R_MOUSE
NC score	0.181566 (rank : 389)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

PIGR_MOUSE
NC score	0.181274 (rank : 390)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	485	Target Neighborhood Hits	214	Shared Neighborhood Hits	116
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

RIMB2_HUMAN
NC score	0.180501 (rank : 391)	θ value	2.61198e-07 (rank : 231)
Query Neighborhood Hits	485	Target Neighborhood Hits	263	Shared Neighborhood Hits	62
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

UNC5A_MOUSE
NC score	0.178985 (rank : 392)	θ value	1.38821 (rank : 423)
Query Neighborhood Hits	485	Target Neighborhood Hits	203	Shared Neighborhood Hits	115
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

HCFC2_HUMAN
NC score	0.178898 (rank : 393)	θ value	0.0148317 (rank : 337)
Query Neighborhood Hits	485	Target Neighborhood Hits	154	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

IL1R1_MOUSE
NC score	0.178063 (rank : 394)	θ value	0.163984 (rank : 375)
Query Neighborhood Hits	485	Target Neighborhood Hits	142	Shared Neighborhood Hits	117
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

INSRR_HUMAN
NC score	0.177340 (rank : 395)	θ value	2.88788e-06 (rank : 245)
Query Neighborhood Hits	485	Target Neighborhood Hits	950	Shared Neighborhood Hits	141
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PDL1_HUMAN
NC score	0.177296 (rank : 396)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	485	Target Neighborhood Hits	195	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

I12R1_MOUSE
NC score	0.177285 (rank : 397)	θ value	5.44631e-05 (rank : 275)
Query Neighborhood Hits	485	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

CD276_MOUSE
NC score	0.174807 (rank : 398)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	485	Target Neighborhood Hits	243	Shared Neighborhood Hits	143
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

IGF1R_HUMAN
NC score	0.174683 (rank : 399)	θ value	0.00020696 (rank : 290)
Query Neighborhood Hits	485	Target Neighborhood Hits	977	Shared Neighborhood Hits	141
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

EMB_MOUSE
NC score	0.174206 (rank : 400)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	485	Target Neighborhood Hits	83	Shared Neighborhood Hits	73
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

RIMB2_MOUSE
NC score	0.174049 (rank : 401)	θ value	1.17247e-07 (rank : 225)
Query Neighborhood Hits	485	Target Neighborhood Hits	246	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

INSRR_MOUSE
NC score	0.173911 (rank : 402)	θ value	0.00035302 (rank : 296)
Query Neighborhood Hits	485	Target Neighborhood Hits	961	Shared Neighborhood Hits	141
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PVRL3_HUMAN
NC score	0.173695 (rank : 403)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	485	Target Neighborhood Hits	204	Shared Neighborhood Hits	124
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

PIGR_HUMAN
NC score	0.173636 (rank : 404)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	485	Target Neighborhood Hits	164	Shared Neighborhood Hits	96
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

IGF1R_MOUSE
NC score	0.173536 (rank : 405)	θ value	0.000270298 (rank : 291)
Query Neighborhood Hits	485	Target Neighborhood Hits	973	Shared Neighborhood Hits	142
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ILRL2_MOUSE
NC score	0.172754 (rank : 406)	θ value	8.99809 (rank : 471)
Query Neighborhood Hits	485	Target Neighborhood Hits	158	Shared Neighborhood Hits	129
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

INSR_MOUSE
NC score	0.172102 (rank : 407)	θ value	0.00035302 (rank : 297)
Query Neighborhood Hits	485	Target Neighborhood Hits	968	Shared Neighborhood Hits	141
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

PVRL1_HUMAN
NC score	0.171047 (rank : 408)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	485	Target Neighborhood Hits	219	Shared Neighborhood Hits	128
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

LRC24_MOUSE
NC score	0.168858 (rank : 409)	θ value	0.163984 (rank : 379)
Query Neighborhood Hits	485	Target Neighborhood Hits	387	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

EPHA1_MOUSE
NC score	0.168678 (rank : 410)	θ value	2.44474e-05 (rank : 267)
Query Neighborhood Hits	485	Target Neighborhood Hits	958	Shared Neighborhood Hits	148
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

INSR_HUMAN
NC score	0.167901 (rank : 411)	θ value	0.00509761 (rank : 324)
Query Neighborhood Hits	485	Target Neighborhood Hits	963	Shared Neighborhood Hits	137
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHA1_HUMAN
NC score	0.166096 (rank : 412)	θ value	1.38499e-08 (rank : 202)
Query Neighborhood Hits	485	Target Neighborhood Hits	997	Shared Neighborhood Hits	140
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

PDL2_MOUSE
NC score	0.163763 (rank : 413)	θ value	8.99809 (rank : 478)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	92
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

LRC4B_MOUSE
NC score	0.161679 (rank : 414)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	485	Target Neighborhood Hits	484	Shared Neighborhood Hits	191
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

NGL1_MOUSE
NC score	0.159904 (rank : 415)	θ value	6.88961 (rank : 457)
Query Neighborhood Hits	485	Target Neighborhood Hits	512	Shared Neighborhood Hits	187
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_HUMAN
NC score	0.159451 (rank : 416)	θ value	8.99809 (rank : 477)
Query Neighborhood Hits	485	Target Neighborhood Hits	511	Shared Neighborhood Hits	187
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

PGFRL_MOUSE
NC score	0.159412 (rank : 417)	θ value	5.27518 (rank : 453)
Query Neighborhood Hits	485	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

LRC4B_HUMAN
NC score	0.159301 (rank : 418)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	485	Target Neighborhood Hits	479	Shared Neighborhood Hits	189
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

ILRL1_HUMAN
NC score	0.158776 (rank : 419)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	485	Target Neighborhood Hits	167	Shared Neighborhood Hits	118
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

PVRL1_MOUSE
NC score	0.158251 (rank : 420)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	485	Target Neighborhood Hits	201	Shared Neighborhood Hits	123
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

NTRK1_HUMAN
NC score	0.157757 (rank : 421)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	485	Target Neighborhood Hits	1023	Shared Neighborhood Hits	183
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

SIGL7_HUMAN
NC score	0.156461 (rank : 422)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	485	Target Neighborhood Hits	180	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

FLT3_MOUSE
NC score	0.155139 (rank : 423)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	135
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

ANKF1_HUMAN
NC score	0.154956 (rank : 424)	θ value	0.00665767 (rank : 327)
Query Neighborhood Hits	485	Target Neighborhood Hits	126	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

CT075_HUMAN
NC score	0.153897 (rank : 425)	θ value	0.365318 (rank : 388)
Query Neighborhood Hits	485	Target Neighborhood Hits	387	Shared Neighborhood Hits	106
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

I27RA_HUMAN
NC score	0.152296 (rank : 426)	θ value	0.279714 (rank : 384)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

IL27B_HUMAN
NC score	0.147908 (rank : 427)	θ value	0.279714 (rank : 385)
Query Neighborhood Hits	485	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

PVR_HUMAN
NC score	0.146640 (rank : 428)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	485	Target Neighborhood Hits	195	Shared Neighborhood Hits	110
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

CEAM7_HUMAN
NC score	0.146486 (rank : 429)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	485	Target Neighborhood Hits	170	Shared Neighborhood Hits	119
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

PDL1_MOUSE
NC score	0.144591 (rank : 430)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	485	Target Neighborhood Hits	168	Shared Neighborhood Hits	106
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

HHLA2_HUMAN
NC score	0.143996 (rank : 431)	θ value	0.163984 (rank : 373)
Query Neighborhood Hits	485	Target Neighborhood Hits	140	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

LRRC4_HUMAN
NC score	0.143845 (rank : 432)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	485	Target Neighborhood Hits	444	Shared Neighborhood Hits	174
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

PECA1_MOUSE
NC score	0.143435 (rank : 433)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	485	Target Neighborhood Hits	126	Shared Neighborhood Hits	88
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

FLT3_HUMAN
NC score	0.141353 (rank : 434)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	485	Target Neighborhood Hits	843	Shared Neighborhood Hits	126
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

SIG12_MOUSE
NC score	0.140869 (rank : 435)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	485	Target Neighborhood Hits	225	Shared Neighborhood Hits	140
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

PVRL2_MOUSE
NC score	0.137131 (rank : 436)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	112
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

JAML1_MOUSE
NC score	0.135847 (rank : 437)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	485	Target Neighborhood Hits	185	Shared Neighborhood Hits	96
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

TRIO_HUMAN
NC score	0.133814 (rank : 438)	θ value	0.00035302 (rank : 301)
Query Neighborhood Hits	485	Target Neighborhood Hits	1580	Shared Neighborhood Hits	254
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

RYK_HUMAN
NC score	0.131325 (rank : 439)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	485	Target Neighborhood Hits	701	Shared Neighborhood Hits	82
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
NC score	0.129680 (rank : 440)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	485	Target Neighborhood Hits	715	Shared Neighborhood Hits	81
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

FCERA_HUMAN
NC score	0.129247 (rank : 441)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	485	Target Neighborhood Hits	150	Shared Neighborhood Hits	106
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

I11RB_MOUSE
NC score	0.128914 (rank : 442)	θ value	0.0431538 (rank : 358)
Query Neighborhood Hits	485	Target Neighborhood Hits	101	Shared Neighborhood Hits	71
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

TP4A1_HUMAN
NC score	0.128638 (rank : 443)	θ value	0.00390308 (rank : 322)
Query Neighborhood Hits	485	Target Neighborhood Hits	68	Shared Neighborhood Hits	47
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
NC score	0.128638 (rank : 444)	θ value	0.00390308 (rank : 323)
Query Neighborhood Hits	485	Target Neighborhood Hits	68	Shared Neighborhood Hits	47
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

PDL2_HUMAN
NC score	0.126883 (rank : 445)	θ value	2.36792 (rank : 437)
Query Neighborhood Hits	485	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

LTK_HUMAN
NC score	0.126495 (rank : 446)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	485	Target Neighborhood Hits	774	Shared Neighborhood Hits	85
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
NC score	0.126024 (rank : 447)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	485	Target Neighborhood Hits	770	Shared Neighborhood Hits	84
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.125050 (rank : 448)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	485	Target Neighborhood Hits	811	Shared Neighborhood Hits	92
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

OX2G_MOUSE
NC score	0.124890 (rank : 449)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	485	Target Neighborhood Hits	105	Shared Neighborhood Hits	74
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

ALK_HUMAN
NC score	0.123697 (rank : 450)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	485	Target Neighborhood Hits	795	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LRRC4_MOUSE
NC score	0.123005 (rank : 451)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	485	Target Neighborhood Hits	412	Shared Neighborhood Hits	152
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

STYK1_MOUSE
NC score	0.121060 (rank : 452)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	485	Target Neighborhood Hits	779	Shared Neighborhood Hits	85
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

CD80_HUMAN
NC score	0.120696 (rank : 453)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	485	Target Neighborhood Hits	129	Shared Neighborhood Hits	88
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

CT075_MOUSE
NC score	0.120457 (rank : 454)	θ value	1.38821 (rank : 415)
Query Neighborhood Hits	485	Target Neighborhood Hits	358	Shared Neighborhood Hits	88
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

PVRL2_HUMAN
NC score	0.119938 (rank : 455)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	485	Target Neighborhood Hits	185	Shared Neighborhood Hits	106
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

LEPR_HUMAN
NC score	0.119856 (rank : 456)	θ value	0.0193708 (rank : 350)
Query Neighborhood Hits	485	Target Neighborhood Hits	112	Shared Neighborhood Hits	75
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

ILRL1_MOUSE
NC score	0.119595 (rank : 457)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	485	Target Neighborhood Hits	172	Shared Neighborhood Hits	116
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

DDR1_HUMAN
NC score	0.119294 (rank : 458)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	485	Target Neighborhood Hits	819	Shared Neighborhood Hits	87
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
NC score	0.119170 (rank : 459)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	485	Target Neighborhood Hits	818	Shared Neighborhood Hits	87
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

CD79A_HUMAN
NC score	0.118771 (rank : 460)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	485	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

STYK1_HUMAN
NC score	0.118417 (rank : 461)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	485	Target Neighborhood Hits	786	Shared Neighborhood Hits	86
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

TP4A3_HUMAN
NC score	0.118031 (rank : 462)	θ value	0.00134147 (rank : 314)
Query Neighborhood Hits	485	Target Neighborhood Hits	62	Shared Neighborhood Hits	37
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

RET_MOUSE
NC score	0.117889 (rank : 463)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	485	Target Neighborhood Hits	884	Shared Neighborhood Hits	87
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_HUMAN
NC score	0.117456 (rank : 464)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	485	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

CC14B_HUMAN
NC score	0.116465 (rank : 465)	θ value	0.813845 (rank : 402)
Query Neighborhood Hits	485	Target Neighborhood Hits	114	Shared Neighborhood Hits	66
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

ICAM1_MOUSE
NC score	0.116439 (rank : 466)	θ value	8.99809 (rank : 470)
Query Neighborhood Hits	485	Target Neighborhood Hits	99	Shared Neighborhood Hits	83
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

DDR2_HUMAN
NC score	0.116360 (rank : 467)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	485	Target Neighborhood Hits	818	Shared Neighborhood Hits	84
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FCGR1_HUMAN
NC score	0.116352 (rank : 468)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	485	Target Neighborhood Hits	145	Shared Neighborhood Hits	90
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

I11RA_HUMAN
NC score	0.116289 (rank : 469)	θ value	0.163984 (rank : 374)
Query Neighborhood Hits	485	Target Neighborhood Hits	138	Shared Neighborhood Hits	73
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

I11RA_MOUSE
NC score	0.115795 (rank : 470)	θ value	0.0431538 (rank : 357)
Query Neighborhood Hits	485	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

DDR2_MOUSE
NC score	0.115319 (rank : 471)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	485	Target Neighborhood Hits	813	Shared Neighborhood Hits	84
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

HCFC1_MOUSE
NC score	0.115213 (rank : 472)	θ value	0.0193708 (rank : 347)
Query Neighborhood Hits	485	Target Neighborhood Hits	348	Shared Neighborhood Hits	67
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

TNK1_HUMAN
NC score	0.113938 (rank : 473)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	485	Target Neighborhood Hits	815	Shared Neighborhood Hits	84
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

KSYK_MOUSE
NC score	0.112962 (rank : 474)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	485	Target Neighborhood Hits	944	Shared Neighborhood Hits	90
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.112428 (rank : 475)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	485	Target Neighborhood Hits	901	Shared Neighborhood Hits	89
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TNK1_MOUSE
NC score	0.112163 (rank : 476)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	485	Target Neighborhood Hits	806	Shared Neighborhood Hits	89
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

MET_MOUSE
NC score	0.112093 (rank : 477)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	485	Target Neighborhood Hits	844	Shared Neighborhood Hits	84
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_HUMAN
NC score	0.112055 (rank : 478)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	485	Target Neighborhood Hits	831	Shared Neighborhood Hits	85
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RON_MOUSE
NC score	0.111951 (rank : 479)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	485	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FAK2_HUMAN
NC score	0.111863 (rank : 480)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ACK1_MOUSE
NC score	0.111795 (rank : 481)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	485	Target Neighborhood Hits	1080	Shared Neighborhood Hits	91
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

FAK1_HUMAN
NC score	0.111614 (rank : 482)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	485	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
NC score	0.111360 (rank : 483)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	485	Target Neighborhood Hits	850	Shared Neighborhood Hits	84
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

LAG3_MOUSE
NC score	0.111317 (rank : 484)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	485	Target Neighborhood Hits	117	Shared Neighborhood Hits	70
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

FAK2_MOUSE
NC score	0.111224 (rank : 485)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

AATK_MOUSE
NC score	0.111057 (rank : 486)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	485	Target Neighborhood Hits	942	Shared Neighborhood Hits	87
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ZAP70_MOUSE
NC score	0.110745 (rank : 487)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	485	Target Neighborhood Hits	905	Shared Neighborhood Hits	88
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

TP4A3_MOUSE
NC score	0.110564 (rank : 488)	θ value	0.00228821 (rank : 317)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

CC14B_MOUSE
NC score	0.110454 (rank : 489)	θ value	4.03905 (rank : 445)
Query Neighborhood Hits	485	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

ACK1_HUMAN
NC score	0.110401 (rank : 490)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	485	Target Neighborhood Hits	1140	Shared Neighborhood Hits	91
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ERBB2_HUMAN
NC score	0.110340 (rank : 491)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	485	Target Neighborhood Hits	1073	Shared Neighborhood Hits	94
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB3_HUMAN
NC score	0.110090 (rank : 492)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	485	Target Neighborhood Hits	918	Shared Neighborhood Hits	86
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB4_HUMAN
NC score	0.110073 (rank : 493)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	485	Target Neighborhood Hits	910	Shared Neighborhood Hits	91
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

RON_HUMAN
NC score	0.110042 (rank : 494)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	485	Target Neighborhood Hits	842	Shared Neighborhood Hits	83
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ZAP70_HUMAN
NC score	0.109954 (rank : 495)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	485	Target Neighborhood Hits	893	Shared Neighborhood Hits	88
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

MATK_HUMAN
NC score	0.109750 (rank : 496)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	485	Target Neighborhood Hits	954	Shared Neighborhood Hits	89
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SRMS_HUMAN
NC score	0.109734 (rank : 497)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	485	Target Neighborhood Hits	946	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ERBB2_MOUSE
NC score	0.109679 (rank : 498)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	485	Target Neighborhood Hits	918	Shared Neighborhood Hits	91
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

AATK_HUMAN
NC score	0.109146 (rank : 499)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	485	Target Neighborhood Hits	1243	Shared Neighborhood Hits	94
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EGFR_MOUSE
NC score	0.109045 (rank : 500)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	485	Target Neighborhood Hits	927	Shared Neighborhood Hits	91
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

MATK_MOUSE
NC score	0.109032 (rank : 501)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	485	Target Neighborhood Hits	952	Shared Neighborhood Hits	89
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

TP4A2_HUMAN
NC score	0.108867 (rank : 502)	θ value	0.0148317 (rank : 345)
Query Neighborhood Hits	485	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
NC score	0.108867 (rank : 503)	θ value	0.0148317 (rank : 346)
Query Neighborhood Hits	485	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

ERBB3_MOUSE
NC score	0.108788 (rank : 504)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	485	Target Neighborhood Hits	898	Shared Neighborhood Hits	84
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

SRMS_MOUSE
NC score	0.108453 (rank : 505)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	485	Target Neighborhood Hits	964	Shared Neighborhood Hits	89
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

EGFR_HUMAN
NC score	0.108294 (rank : 506)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	485	Target Neighborhood Hits	939	Shared Neighborhood Hits	88
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

LEPR_MOUSE
NC score	0.107402 (rank : 507)	θ value	2.36792 (rank : 436)
Query Neighborhood Hits	485	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

ILRL2_HUMAN
NC score	0.107290 (rank : 508)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	485	Target Neighborhood Hits	112	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

FES_HUMAN
NC score	0.106853 (rank : 509)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	485	Target Neighborhood Hits	978	Shared Neighborhood Hits	90
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FER_HUMAN
NC score	0.106766 (rank : 510)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	485	Target Neighborhood Hits	1278	Shared Neighborhood Hits	91
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CC14A_MOUSE
NC score	0.106572 (rank : 511)	θ value	1.38821 (rank : 414)
Query Neighborhood Hits	485	Target Neighborhood Hits	117	Shared Neighborhood Hits	64
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

FES_MOUSE
NC score	0.106369 (rank : 512)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	88
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

CD80_MOUSE
NC score	0.105901 (rank : 513)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	485	Target Neighborhood Hits	136	Shared Neighborhood Hits	89
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

ABL1_MOUSE
NC score	0.105523 (rank : 514)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	485	Target Neighborhood Hits	1178	Shared Neighborhood Hits	97
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
NC score	0.105467 (rank : 515)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	485	Target Neighborhood Hits	1045	Shared Neighborhood Hits	93
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

LCK_HUMAN
NC score	0.105299 (rank : 516)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	485	Target Neighborhood Hits	987	Shared Neighborhood Hits	91
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BMX_MOUSE
NC score	0.105294 (rank : 517)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	485	Target Neighborhood Hits	912	Shared Neighborhood Hits	88
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ABL1_HUMAN
NC score	0.105015 (rank : 518)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	485	Target Neighborhood Hits	1220	Shared Neighborhood Hits	94
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

HCK_MOUSE
NC score	0.104903 (rank : 519)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	485	Target Neighborhood Hits	1029	Shared Neighborhood Hits	90
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.104824 (rank : 520)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	485	Target Neighborhood Hits	1035	Shared Neighborhood Hits	92
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

LCK_MOUSE
NC score	0.104733 (rank : 521)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	485	Target Neighborhood Hits	981	Shared Neighborhood Hits	89
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BLK_MOUSE
NC score	0.104669 (rank : 522)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	485	Target Neighborhood Hits	992	Shared Neighborhood Hits	91
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

OX2G_HUMAN
NC score	0.104630 (rank : 523)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	485	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

BMX_HUMAN
NC score	0.104523 (rank : 524)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	485	Target Neighborhood Hits	942	Shared Neighborhood Hits	88
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

FGR_MOUSE
NC score	0.104429 (rank : 525)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	485	Target Neighborhood Hits	1069	Shared Neighborhood Hits	93
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FRK_HUMAN
NC score	0.104270 (rank : 526)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	485	Target Neighborhood Hits	1058	Shared Neighborhood Hits	89
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

TXK_MOUSE
NC score	0.104267 (rank : 527)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	89
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CSK_HUMAN
NC score	0.104254 (rank : 528)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	93
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CC14A_HUMAN
NC score	0.104239 (rank : 529)	θ value	1.38821 (rank : 413)
Query Neighborhood Hits	485	Target Neighborhood Hits	133	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

BTK_HUMAN
NC score	0.103772 (rank : 530)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	485	Target Neighborhood Hits	1026	Shared Neighborhood Hits	92
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.103540 (rank : 531)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	485	Target Neighborhood Hits	1017	Shared Neighborhood Hits	92
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BLK_HUMAN
NC score	0.103534 (rank : 532)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	485	Target Neighborhood Hits	994	Shared Neighborhood Hits	90
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SHPS1_HUMAN
NC score	0.103310 (rank : 533)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	485	Target Neighborhood Hits	455	Shared Neighborhood Hits	107
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

ITK_MOUSE
NC score	0.103204 (rank : 534)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	485	Target Neighborhood Hits	985	Shared Neighborhood Hits	88
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

TXK_HUMAN
NC score	0.103144 (rank : 535)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	485	Target Neighborhood Hits	971	Shared Neighborhood Hits	88
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

YES_HUMAN
NC score	0.103017 (rank : 536)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	485	Target Neighborhood Hits	1059	Shared Neighborhood Hits	94
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_HUMAN
NC score	0.102994 (rank : 537)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	485	Target Neighborhood Hits	1067	Shared Neighborhood Hits	93
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TEC_HUMAN
NC score	0.102888 (rank : 538)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	485	Target Neighborhood Hits	1006	Shared Neighborhood Hits	89
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

YES_MOUSE
NC score	0.102762 (rank : 539)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	485	Target Neighborhood Hits	1052	Shared Neighborhood Hits	93
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

LYN_MOUSE
NC score	0.102624 (rank : 540)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	485	Target Neighborhood Hits	1023	Shared Neighborhood Hits	91
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CSK_MOUSE
NC score	0.102480 (rank : 541)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	485	Target Neighborhood Hits	1009	Shared Neighborhood Hits	93
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

TEC_MOUSE
NC score	0.102364 (rank : 542)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	485	Target Neighborhood Hits	1006	Shared Neighborhood Hits	89
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LYN_HUMAN
NC score	0.102360 (rank : 543)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	485	Target Neighborhood Hits	1022	Shared Neighborhood Hits	89
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ITK_HUMAN
NC score	0.102258 (rank : 544)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	485	Target Neighborhood Hits	1016	Shared Neighborhood Hits	88
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SRC_MOUSE
NC score	0.102229 (rank : 545)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	485	Target Neighborhood Hits	1033	Shared Neighborhood Hits	92
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

PTK6_MOUSE
NC score	0.102167 (rank : 546)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	485	Target Neighborhood Hits	1026	Shared Neighborhood Hits	89
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

IL6RA_MOUSE
NC score	0.101955 (rank : 547)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	485	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

SRC_HUMAN
NC score	0.101710 (rank : 548)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	485	Target Neighborhood Hits	1058	Shared Neighborhood Hits	92
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

MFAP3_HUMAN
NC score	0.101099 (rank : 549)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	485	Target Neighborhood Hits	91	Shared Neighborhood Hits	76
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MAMC2_MOUSE
NC score	0.101074 (rank : 550)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	485	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

LAG3_HUMAN
NC score	0.101055 (rank : 551)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	485	Target Neighborhood Hits	129	Shared Neighborhood Hits	64
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

FYN_MOUSE
NC score	0.100942 (rank : 552)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	485	Target Neighborhood Hits	1073	Shared Neighborhood Hits	91
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FYN_HUMAN
NC score	0.099954 (rank : 553)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	485	Target Neighborhood Hits	1078	Shared Neighborhood Hits	91
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

PTK6_HUMAN
NC score	0.099882 (rank : 554)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	485	Target Neighborhood Hits	1020	Shared Neighborhood Hits	89
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTEN_HUMAN
NC score	0.099644 (rank : 555)	θ value	0.0736092 (rank : 364)
Query Neighborhood Hits	485	Target Neighborhood Hits	72	Shared Neighborhood Hits	43
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
NC score	0.099642 (rank : 556)	θ value	0.0736092 (rank : 365)
Query Neighborhood Hits	485	Target Neighborhood Hits	73	Shared Neighborhood Hits	43
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

JAK1_MOUSE
NC score	0.099216 (rank : 557)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	485	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_HUMAN
NC score	0.098588 (rank : 558)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	485	Target Neighborhood Hits	858	Shared Neighborhood Hits	89
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MAMC2_HUMAN
NC score	0.098406 (rank : 559)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	485	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

HCFC1_HUMAN
NC score	0.098188 (rank : 560)	θ value	0.0961366 (rank : 368)
Query Neighborhood Hits	485	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

ICAM3_HUMAN
NC score	0.097967 (rank : 561)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	485	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

JAK3_HUMAN
NC score	0.095397 (rank : 562)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	485	Target Neighborhood Hits	827	Shared Neighborhood Hits	84
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK2_HUMAN
NC score	0.094414 (rank : 563)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
NC score	0.094045 (rank : 564)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	485	Target Neighborhood Hits	839	Shared Neighborhood Hits	84
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

ICAM1_HUMAN
NC score	0.093869 (rank : 565)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	485	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

I27RA_MOUSE
NC score	0.093613 (rank : 566)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	40
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

TYK2_MOUSE
NC score	0.093307 (rank : 567)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	485	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_HUMAN
NC score	0.092418 (rank : 568)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	485	Target Neighborhood Hits	841	Shared Neighborhood Hits	85
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_MOUSE
NC score	0.092145 (rank : 569)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	485	Target Neighborhood Hits	821	Shared Neighborhood Hits	84
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

EMB_HUMAN
NC score	0.092130 (rank : 570)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	485	Target Neighborhood Hits	54	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

SIRB1_HUMAN
NC score	0.091923 (rank : 571)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	485	Target Neighborhood Hits	422	Shared Neighborhood Hits	98
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

FCGR1_MOUSE
NC score	0.091130 (rank : 572)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	485	Target Neighborhood Hits	123	Shared Neighborhood Hits	76
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

MFAP3_MOUSE
NC score	0.088811 (rank : 573)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	485	Target Neighborhood Hits	97	Shared Neighborhood Hits	80
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

GUC2C_HUMAN
NC score	0.088403 (rank : 574)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	485	Target Neighborhood Hits	624	Shared Neighborhood Hits	79
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

MLKL_HUMAN
NC score	0.087559 (rank : 575)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	485	Target Neighborhood Hits	600	Shared Neighborhood Hits	79
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

FPRP_HUMAN
NC score	0.086826 (rank : 576)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	485	Target Neighborhood Hits	130	Shared Neighborhood Hits	83
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

GUC2F_HUMAN
NC score	0.086650 (rank : 577)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	485	Target Neighborhood Hits	740	Shared Neighborhood Hits	83
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

IGSF2_HUMAN
NC score	0.086004 (rank : 578)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	485	Target Neighborhood Hits	208	Shared Neighborhood Hits	85
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

CD4_HUMAN
NC score	0.085573 (rank : 579)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	485	Target Neighborhood Hits	122	Shared Neighborhood Hits	50
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

BT3A2_HUMAN
NC score	0.084350 (rank : 580)	θ value	0.62314 (rank : 399)
Query Neighborhood Hits	485	Target Neighborhood Hits	158	Shared Neighborhood Hits	77
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

M3KL4_HUMAN
NC score	0.083526 (rank : 581)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	485	Target Neighborhood Hits	1087	Shared Neighborhood Hits	88
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

BTNL2_HUMAN
NC score	0.082367 (rank : 582)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	485	Target Neighborhood Hits	164	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

MLKL_MOUSE
NC score	0.082349 (rank : 583)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	485	Target Neighborhood Hits	707	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_MOUSE
NC score	0.081988 (rank : 584)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

M3K12_HUMAN
NC score	0.081860 (rank : 585)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	485	Target Neighborhood Hits	940	Shared Neighborhood Hits	88
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

MLTK_HUMAN
NC score	0.081801 (rank : 586)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	485	Target Neighborhood Hits	911	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ILK_MOUSE
NC score	0.081780 (rank : 587)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	485	Target Neighborhood Hits	858	Shared Neighborhood Hits	83
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

MOX2R_HUMAN
NC score	0.081679 (rank : 588)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	485	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

M3K12_MOUSE
NC score	0.081653 (rank : 589)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	485	Target Neighborhood Hits	957	Shared Neighborhood Hits	88
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

ILK1_HUMAN
NC score	0.081395 (rank : 590)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	485	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

PRLR_HUMAN
NC score	0.081225 (rank : 591)	θ value	2.36792 (rank : 438)
Query Neighborhood Hits	485	Target Neighborhood Hits	95	Shared Neighborhood Hits	52
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

ARAF_HUMAN
NC score	0.081031 (rank : 592)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	485	Target Neighborhood Hits	924	Shared Neighborhood Hits	85
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

AMGO2_HUMAN
NC score	0.080964 (rank : 593)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	485	Target Neighborhood Hits	357	Shared Neighborhood Hits	120
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

ARAF_MOUSE
NC score	0.080963 (rank : 594)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

M3K10_HUMAN
NC score	0.080928 (rank : 595)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	485	Target Neighborhood Hits	1071	Shared Neighborhood Hits	89
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

BRAF1_HUMAN
NC score	0.080822 (rank : 596)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	485	Target Neighborhood Hits	883	Shared Neighborhood Hits	86
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

M3K9_HUMAN
NC score	0.080739 (rank : 597)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	485	Target Neighborhood Hits	1123	Shared Neighborhood Hits	91
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

RAF1_MOUSE
NC score	0.080473 (rank : 598)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	485	Target Neighborhood Hits	886	Shared Neighborhood Hits	85
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

M3K11_HUMAN
NC score	0.079994 (rank : 599)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	485	Target Neighborhood Hits	1136	Shared Neighborhood Hits	94
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ILK2_HUMAN
NC score	0.079857 (rank : 600)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	485	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

RAF1_HUMAN
NC score	0.079820 (rank : 601)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	485	Target Neighborhood Hits	886	Shared Neighborhood Hits	84
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

M3K13_HUMAN
NC score	0.079424 (rank : 602)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	485	Target Neighborhood Hits	911	Shared Neighborhood Hits	84
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

FPRP_MOUSE
NC score	0.078485 (rank : 603)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

TESK2_MOUSE
NC score	0.078333 (rank : 604)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	485	Target Neighborhood Hits	833	Shared Neighborhood Hits	84
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_HUMAN
NC score	0.078318 (rank : 605)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

M3K7_MOUSE
NC score	0.077755 (rank : 606)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	485	Target Neighborhood Hits	892	Shared Neighborhood Hits	84
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.077694 (rank : 607)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	485	Target Neighborhood Hits	892	Shared Neighborhood Hits	84
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

IRAK3_MOUSE
NC score	0.077346 (rank : 608)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	485	Target Neighborhood Hits	628	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

LRRK1_MOUSE
NC score	0.077284 (rank : 609)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	485	Target Neighborhood Hits	1267	Shared Neighborhood Hits	112
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

IL6RA_HUMAN
NC score	0.077228 (rank : 610)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	485	Target Neighborhood Hits	96	Shared Neighborhood Hits	58
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

IL27B_MOUSE
NC score	0.077108 (rank : 611)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	41
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

GUC2E_MOUSE
NC score	0.076947 (rank : 612)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	485	Target Neighborhood Hits	692	Shared Neighborhood Hits	83
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

PRLR_MOUSE
NC score	0.076894 (rank : 613)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	485	Target Neighborhood Hits	82	Shared Neighborhood Hits	44
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

RIPK3_HUMAN
NC score	0.076640 (rank : 614)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	485	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

MOS_HUMAN
NC score	0.076315 (rank : 615)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	485	Target Neighborhood Hits	829	Shared Neighborhood Hits	84
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

KSR1_HUMAN
NC score	0.076024 (rank : 616)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

FRMD1_HUMAN
NC score	0.075737 (rank : 617)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	485	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

RIPK2_MOUSE
NC score	0.075690 (rank : 618)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	485	Target Neighborhood Hits	776	Shared Neighborhood Hits	83
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

LRRK1_HUMAN
NC score	0.075489 (rank : 619)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	485	Target Neighborhood Hits	1237	Shared Neighborhood Hits	113
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LIMK2_MOUSE
NC score	0.075158 (rank : 620)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	485	Target Neighborhood Hits	998	Shared Neighborhood Hits	87
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

KSR1_MOUSE
NC score	0.075063 (rank : 621)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	485	Target Neighborhood Hits	870	Shared Neighborhood Hits	87
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

LIMK2_HUMAN
NC score	0.074802 (rank : 622)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	485	Target Neighborhood Hits	986	Shared Neighborhood Hits	87
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK1_HUMAN
NC score	0.074505 (rank : 623)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	485	Target Neighborhood Hits	1005	Shared Neighborhood Hits	86
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

TESK1_MOUSE
NC score	0.074365 (rank : 624)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	485	Target Neighborhood Hits	862	Shared Neighborhood Hits	85
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

LIMK1_MOUSE
NC score	0.074281 (rank : 625)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	485	Target Neighborhood Hits	1008	Shared Neighborhood Hits	87
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

TPSNR_MOUSE
NC score	0.074255 (rank : 626)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	485	Target Neighborhood Hits	336	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

RIPK1_MOUSE
NC score	0.074153 (rank : 627)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_HUMAN
NC score	0.073752 (rank : 628)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	485	Target Neighborhood Hits	891	Shared Neighborhood Hits	86
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TESK1_HUMAN
NC score	0.073568 (rank : 629)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	485	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

RIPK2_HUMAN
NC score	0.073444 (rank : 630)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	485	Target Neighborhood Hits	774	Shared Neighborhood Hits	82
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

IRAK3_HUMAN
NC score	0.073409 (rank : 631)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	485	Target Neighborhood Hits	644	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

FRMD6_MOUSE
NC score	0.073353 (rank : 632)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	485	Target Neighborhood Hits	63	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

FRMD6_HUMAN
NC score	0.071727 (rank : 633)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

TEX14_HUMAN
NC score	0.071564 (rank : 634)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	485	Target Neighborhood Hits	1103	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

E41LA_MOUSE
NC score	0.071228 (rank : 635)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	485	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

MOS_MOUSE
NC score	0.071113 (rank : 636)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	485	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

E41LA_HUMAN
NC score	0.071029 (rank : 637)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	485	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

GUC2D_HUMAN
NC score	0.070875 (rank : 638)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	485	Target Neighborhood Hits	715	Shared Neighborhood Hits	83
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

IRAK4_HUMAN
NC score	0.070858 (rank : 639)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	485	Target Neighborhood Hits	816	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

ANPRA_MOUSE
NC score	0.070078 (rank : 640)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	485	Target Neighborhood Hits	600	Shared Neighborhood Hits	79
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

TOPK_MOUSE
NC score	0.069810 (rank : 641)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	485	Target Neighborhood Hits	618	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

FCRLA_HUMAN
NC score	0.069242 (rank : 642)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	485	Target Neighborhood Hits	135	Shared Neighborhood Hits	47
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

ANPRA_HUMAN
NC score	0.069188 (rank : 643)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	485	Target Neighborhood Hits	612	Shared Neighborhood Hits	79
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

TEX14_MOUSE
NC score	0.069057 (rank : 644)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	485	Target Neighborhood Hits	1333	Shared Neighborhood Hits	86
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

IRAK4_MOUSE
NC score	0.069050 (rank : 645)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	485	Target Neighborhood Hits	820	Shared Neighborhood Hits	85
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

E41LB_MOUSE
NC score	0.068787 (rank : 646)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	485	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

TOPK_HUMAN
NC score	0.068715 (rank : 647)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	485	Target Neighborhood Hits	605	Shared Neighborhood Hits	76
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

E41L5_HUMAN
NC score	0.068283 (rank : 648)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	485	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

FCG2B_HUMAN
NC score	0.068140 (rank : 649)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	485	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

JAML1_HUMAN
NC score	0.068120 (rank : 650)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	485	Target Neighborhood Hits	108	Shared Neighborhood Hits	47
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

FCG2C_HUMAN
NC score	0.067762 (rank : 651)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	485	Target Neighborhood Hits	118	Shared Neighborhood Hits	67
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

E41L3_HUMAN
NC score	0.067627 (rank : 652)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	485	Target Neighborhood Hits	113	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

AMGO2_MOUSE
NC score	0.067593 (rank : 653)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	485	Target Neighborhood Hits	329	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

GUC2G_MOUSE
NC score	0.067330 (rank : 654)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	485	Target Neighborhood Hits	644	Shared Neighborhood Hits	78
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

FCRLA_MOUSE
NC score	0.067206 (rank : 655)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	52
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

E41LB_HUMAN
NC score	0.067187 (rank : 656)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	485	Target Neighborhood Hits	79	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

ACVL1_MOUSE
NC score	0.067088 (rank : 657)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	485	Target Neighborhood Hits	739	Shared Neighborhood Hits	78
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

FRMD5_MOUSE
NC score	0.066467 (rank : 658)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

KSR2_HUMAN
NC score	0.066417 (rank : 659)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	485	Target Neighborhood Hits	920	Shared Neighborhood Hits	86
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

41_HUMAN
NC score	0.066351 (rank : 660)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	485	Target Neighborhood Hits	157	Shared Neighborhood Hits	15
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

SIGL9_HUMAN
NC score	0.066300 (rank : 661)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	485	Target Neighborhood Hits	76	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

BT1A1_MOUSE
NC score	0.066066 (rank : 662)	θ value	1.81305 (rank : 424)
Query Neighborhood Hits	485	Target Neighborhood Hits	252	Shared Neighborhood Hits	111
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

LRRK2_HUMAN
NC score	0.066065 (rank : 663)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	485	Target Neighborhood Hits	1382	Shared Neighborhood Hits	109
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

41_MOUSE
NC score	0.066054 (rank : 664)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	485	Target Neighborhood Hits	184	Shared Neighborhood Hits	15
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

FRMD5_HUMAN
NC score	0.065866 (rank : 665)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	485	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L2_HUMAN
NC score	0.065837 (rank : 666)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	485	Target Neighborhood Hits	287	Shared Neighborhood Hits	14
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

RIPK5_HUMAN
NC score	0.065434 (rank : 667)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	485	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

TNI3K_MOUSE
NC score	0.065426 (rank : 668)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	485	Target Neighborhood Hits	1079	Shared Neighborhood Hits	84
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

AMGO3_HUMAN
NC score	0.065425 (rank : 669)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	485	Target Neighborhood Hits	276	Shared Neighborhood Hits	73
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

RIPK5_MOUSE
NC score	0.065422 (rank : 670)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

TNI3K_HUMAN
NC score	0.065031 (rank : 671)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	485	Target Neighborhood Hits	1084	Shared Neighborhood Hits	83
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TRIM9_HUMAN
NC score	0.064819 (rank : 672)	θ value	0.365318 (rank : 393)
Query Neighborhood Hits	485	Target Neighborhood Hits	294	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

E41L1_MOUSE
NC score	0.064781 (rank : 673)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	485	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

IRAK1_MOUSE
NC score	0.064779 (rank : 674)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	485	Target Neighborhood Hits	784	Shared Neighborhood Hits	85
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK1_HUMAN
NC score	0.064745 (rank : 675)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	485	Target Neighborhood Hits	820	Shared Neighborhood Hits	83
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

MYLIP_MOUSE
NC score	0.064697 (rank : 676)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	485	Target Neighborhood Hits	139	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

ANPRB_HUMAN
NC score	0.064656 (rank : 677)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	485	Target Neighborhood Hits	646	Shared Neighborhood Hits	79
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

E41L3_MOUSE
NC score	0.064574 (rank : 678)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	485	Target Neighborhood Hits	250	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L1_HUMAN
NC score	0.064458 (rank : 679)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	485	Target Neighborhood Hits	180	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

SHPS1_MOUSE
NC score	0.064451 (rank : 680)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	485	Target Neighborhood Hits	439	Shared Neighborhood Hits	92
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

ACVL1_HUMAN
NC score	0.064110 (rank : 681)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	485	Target Neighborhood Hits	716	Shared Neighborhood Hits	77
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ANPRB_MOUSE
NC score	0.063821 (rank : 682)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	485	Target Neighborhood Hits	607	Shared Neighborhood Hits	79
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

LRRK2_MOUSE
NC score	0.063737 (rank : 683)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	485	Target Neighborhood Hits	1359	Shared Neighborhood Hits	110
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

TGFR2_HUMAN
NC score	0.063263 (rank : 684)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	485	Target Neighborhood Hits	748	Shared Neighborhood Hits	82
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

SIGIR_MOUSE
NC score	0.062699 (rank : 685)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	485	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

TGFR2_MOUSE
NC score	0.062412 (rank : 686)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	485	Target Neighborhood Hits	748	Shared Neighborhood Hits	83
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TPSNR_HUMAN
NC score	0.062246 (rank : 687)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	485	Target Neighborhood Hits	330	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

NAGPA_MOUSE
NC score	0.061691 (rank : 688)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	485	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

CRLF2_MOUSE
NC score	0.061429 (rank : 689)	θ value	1.81305 (rank : 426)
Query Neighborhood Hits	485	Target Neighborhood Hits	39	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

E41L2_MOUSE
NC score	0.061272 (rank : 690)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	485	Target Neighborhood Hits	459	Shared Neighborhood Hits	14
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

FRM4A_HUMAN
NC score	0.061013 (rank : 691)	θ value	3.0926 (rank : 440)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

MYLIP_HUMAN
NC score	0.060958 (rank : 692)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	485	Target Neighborhood Hits	162	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

FRM4B_MOUSE
NC score	0.060883 (rank : 693)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	485	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

AMGO3_MOUSE
NC score	0.060776 (rank : 694)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	485	Target Neighborhood Hits	276	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

IKKA_HUMAN
NC score	0.060415 (rank : 695)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	485	Target Neighborhood Hits	863	Shared Neighborhood Hits	84
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
NC score	0.060020 (rank : 696)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

RIPK3_MOUSE
NC score	0.059897 (rank : 697)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

FCN1_MOUSE
NC score	0.059807 (rank : 698)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	485	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

NEK11_MOUSE
NC score	0.059414 (rank : 699)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	485	Target Neighborhood Hits	875	Shared Neighborhood Hits	84
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NAGPA_HUMAN
NC score	0.059357 (rank : 700)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	485	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

FRM4B_HUMAN
NC score	0.059014 (rank : 701)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	485	Target Neighborhood Hits	117	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

STK24_MOUSE
NC score	0.058970 (rank : 702)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	485	Target Neighborhood Hits	856	Shared Neighborhood Hits	84
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

TGFR1_MOUSE
NC score	0.058837 (rank : 703)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	485	Target Neighborhood Hits	753	Shared Neighborhood Hits	83
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

STK24_HUMAN
NC score	0.058778 (rank : 704)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	485	Target Neighborhood Hits	853	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

TRIM9_MOUSE
NC score	0.058760 (rank : 705)	θ value	1.38821 (rank : 421)
Query Neighborhood Hits	485	Target Neighborhood Hits	274	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

CDKN3_HUMAN
NC score	0.058739 (rank : 706)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	485	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

NEK11_HUMAN
NC score	0.058609 (rank : 707)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	485	Target Neighborhood Hits	1043	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TGFR1_HUMAN
NC score	0.058567 (rank : 708)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	485	Target Neighborhood Hits	755	Shared Neighborhood Hits	83
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

FCN1_HUMAN
NC score	0.058461 (rank : 709)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	485	Target Neighborhood Hits	147	Shared Neighborhood Hits	13
SwissProt Accessions	O00602, Q92596	Gene names	FCN1
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

MST4_HUMAN
NC score	0.058433 (rank : 710)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	485	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
NC score	0.058336 (rank : 711)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	485	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

SIRPG_HUMAN
NC score	0.058321 (rank : 712)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	485	Target Neighborhood Hits	359	Shared Neighborhood Hits	76
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

FRM4A_MOUSE
NC score	0.058143 (rank : 713)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	485	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

IL1AP_MOUSE
NC score	0.058135 (rank : 714)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	485	Target Neighborhood Hits	94	Shared Neighborhood Hits	51
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

LY9_MOUSE
NC score	0.057623 (rank : 715)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	485	Target Neighborhood Hits	110	Shared Neighborhood Hits	57
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

NEK7_MOUSE
NC score	0.057489 (rank : 716)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	485	Target Neighborhood Hits	847	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

AMGO1_HUMAN
NC score	0.057464 (rank : 717)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	485	Target Neighborhood Hits	353	Shared Neighborhood Hits	90
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

NEK7_HUMAN
NC score	0.057435 (rank : 718)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	485	Target Neighborhood Hits	846	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

BMR1A_HUMAN
NC score	0.057219 (rank : 719)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	485	Target Neighborhood Hits	759	Shared Neighborhood Hits	82
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

KR171_HUMAN
NC score	0.057135 (rank : 720)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	485	Target Neighborhood Hits	144	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

A1BG_HUMAN
NC score	0.057087 (rank : 721)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	485	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

BMR1A_MOUSE
NC score	0.057045 (rank : 722)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	485	Target Neighborhood Hits	758	Shared Neighborhood Hits	82
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

FCN2_HUMAN
NC score	0.057011 (rank : 723)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	485	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q15485, Q9UC57	Gene names	FCN2
Domain Architecture
Description	Ficolin-2 precursor (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin B) (Serum lectin p35) (EBP-37) (Hucolin) (L- Ficolin).

BT1A1_HUMAN
NC score	0.056989 (rank : 724)	θ value	0.813845 (rank : 401)
Query Neighborhood Hits	485	Target Neighborhood Hits	322	Shared Neighborhood Hits	104
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

FCN3_HUMAN
NC score	0.056970 (rank : 725)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	485	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	O75636, Q6IBJ5, Q8WW86	Gene names	FCN3, HAKA1
Domain Architecture
Description	Ficolin-3 precursor (Collagen/fibrinogen domain-containing protein 3) (Collagen/fibrinogen domain-containing lectin 3 p35) (Hakata antigen).

BMR1B_MOUSE
NC score	0.056887 (rank : 726)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	485	Target Neighborhood Hits	758	Shared Neighborhood Hits	80
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

YSK4_HUMAN
NC score	0.056841 (rank : 727)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	485	Target Neighborhood Hits	921	Shared Neighborhood Hits	87
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ACV1C_HUMAN
NC score	0.056685 (rank : 728)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	485	Target Neighborhood Hits	709	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

BMPR2_HUMAN
NC score	0.056532 (rank : 729)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	485	Target Neighborhood Hits	736	Shared Neighborhood Hits	79
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

SREC2_HUMAN
NC score	0.056054 (rank : 730)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	485	Target Neighborhood Hits	645	Shared Neighborhood Hits	48
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

NEK6_HUMAN
NC score	0.056023 (rank : 731)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	485	Target Neighborhood Hits	848	Shared Neighborhood Hits	84
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

BMR1B_HUMAN
NC score	0.056022 (rank : 732)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	485	Target Neighborhood Hits	760	Shared Neighborhood Hits	80
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

MYLK2_HUMAN
NC score	0.055925 (rank : 733)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	485	Target Neighborhood Hits	920	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEK6_MOUSE
NC score	0.055881 (rank : 734)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

FARP1_HUMAN
NC score	0.055814 (rank : 735)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	485	Target Neighborhood Hits	241	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

STK25_MOUSE
NC score	0.055501 (rank : 736)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	485	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MERL_MOUSE
NC score	0.055476 (rank : 737)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	485	Target Neighborhood Hits	524	Shared Neighborhood Hits	12
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

SUSD1_HUMAN
NC score	0.055450 (rank : 738)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	485	Target Neighborhood Hits	285	Shared Neighborhood Hits	29
SwissProt Accessions	Q6UWL2, Q5T8V7, Q6P9G7, Q8WU83, Q9H6V2, Q9NTA7	Gene names	SUSD1
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 1 precursor.

NEK4_HUMAN
NC score	0.055431 (rank : 739)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	485	Target Neighborhood Hits	883	Shared Neighborhood Hits	84
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

I18RA_MOUSE
NC score	0.055399 (rank : 740)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	485	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

MP2K5_MOUSE
NC score	0.055339 (rank : 741)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	485	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MERL_HUMAN
NC score	0.055260 (rank : 742)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	485	Target Neighborhood Hits	532	Shared Neighborhood Hits	12
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

STK25_HUMAN
NC score	0.055242 (rank : 743)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	485	Target Neighborhood Hits	853	Shared Neighborhood Hits	84
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

ACVR1_MOUSE
NC score	0.055235 (rank : 744)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	485	Target Neighborhood Hits	768	Shared Neighborhood Hits	81
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

NEK4_MOUSE
NC score	0.055210 (rank : 745)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	485	Target Neighborhood Hits	899	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

STK4_MOUSE
NC score	0.055131 (rank : 746)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	485	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

IKKB_HUMAN
NC score	0.055123 (rank : 747)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	485	Target Neighborhood Hits	980	Shared Neighborhood Hits	84
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MP2K5_HUMAN
NC score	0.055099 (rank : 748)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	485	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

BMPR2_MOUSE
NC score	0.055088 (rank : 749)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	485	Target Neighborhood Hits	738	Shared Neighborhood Hits	79
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

IKKB_MOUSE
NC score	0.055000 (rank : 750)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	485	Target Neighborhood Hits	984	Shared Neighborhood Hits	85
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

STK4_HUMAN
NC score	0.054959 (rank : 751)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	485	Target Neighborhood Hits	870	Shared Neighborhood Hits	84
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK3_MOUSE
NC score	0.054717 (rank : 752)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	485	Target Neighborhood Hits	869	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

I18RA_HUMAN
NC score	0.054671 (rank : 753)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	485	Target Neighborhood Hits	97	Shared Neighborhood Hits	55
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

ANKK1_MOUSE
NC score	0.054655 (rank : 754)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	485	Target Neighborhood Hits	1072	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ACVR1_HUMAN
NC score	0.054588 (rank : 755)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	485	Target Neighborhood Hits	760	Shared Neighborhood Hits	81
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

FARP2_MOUSE
NC score	0.054475 (rank : 756)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	485	Target Neighborhood Hits	209	Shared Neighborhood Hits	13
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

STK3_HUMAN
NC score	0.054290 (rank : 757)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	485	Target Neighborhood Hits	861	Shared Neighborhood Hits	85
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

ACV1C_MOUSE
NC score	0.054063 (rank : 758)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	485	Target Neighborhood Hits	715	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

MFAP4_MOUSE
NC score	0.054025 (rank : 759)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D1H9, Q5NCN1	Gene names	Mfap4
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 4 precursor.

IRAK2_HUMAN
NC score	0.054023 (rank : 760)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	485	Target Neighborhood Hits	714	Shared Neighborhood Hits	69
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

STK16_HUMAN
NC score	0.053934 (rank : 761)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	485	Target Neighborhood Hits	824	Shared Neighborhood Hits	82
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

MFAP4_HUMAN
NC score	0.053931 (rank : 762)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	P55083, Q6P680	Gene names	MFAP4
Domain Architecture
Description	Microfibril-associated glycoprotein 4 precursor.

E2AK2_HUMAN
NC score	0.053910 (rank : 763)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	485	Target Neighborhood Hits	856	Shared Neighborhood Hits	83
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

STK16_MOUSE
NC score	0.053850 (rank : 764)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	485	Target Neighborhood Hits	824	Shared Neighborhood Hits	82
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

RIPK4_HUMAN
NC score	0.053713 (rank : 765)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	485	Target Neighborhood Hits	1094	Shared Neighborhood Hits	86
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

GP116_HUMAN
NC score	0.053613 (rank : 766)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	485	Target Neighborhood Hits	167	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

SREC_HUMAN
NC score	0.053604 (rank : 767)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	485	Target Neighborhood Hits	645	Shared Neighborhood Hits	43
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

STK33_HUMAN
NC score	0.053596 (rank : 768)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	485	Target Neighborhood Hits	879	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

FARP2_HUMAN
NC score	0.053516 (rank : 769)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	485	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ACV1B_MOUSE
NC score	0.053220 (rank : 770)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	485	Target Neighborhood Hits	753	Shared Neighborhood Hits	82
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

DAPK3_HUMAN
NC score	0.052850 (rank : 771)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	485	Target Neighborhood Hits	945	Shared Neighborhood Hits	84
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ANKK1_HUMAN
NC score	0.052838 (rank : 772)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	485	Target Neighborhood Hits	1075	Shared Neighborhood Hits	85
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ACV1B_HUMAN
NC score	0.052830 (rank : 773)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	485	Target Neighborhood Hits	753	Shared Neighborhood Hits	82
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

DAPK2_MOUSE
NC score	0.052774 (rank : 774)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	485	Target Neighborhood Hits	834	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

CNTFR_MOUSE
NC score	0.052685 (rank : 775)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	485	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CD226_HUMAN
NC score	0.052596 (rank : 776)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	485	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

STK36_MOUSE
NC score	0.052452 (rank : 777)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	485	Target Neighborhood Hits	877	Shared Neighborhood Hits	84
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ST17B_MOUSE
NC score	0.052373 (rank : 778)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	485	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

DAPK3_MOUSE
NC score	0.052296 (rank : 779)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	485	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK2_HUMAN
NC score	0.052206 (rank : 780)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	485	Target Neighborhood Hits	832	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ULK3_MOUSE
NC score	0.052055 (rank : 781)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	485	Target Neighborhood Hits	872	Shared Neighborhood Hits	84
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

WIF1_HUMAN
NC score	0.052043 (rank : 782)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	485	Target Neighborhood Hits	392	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

LAMA5_HUMAN
NC score	0.051865 (rank : 783)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	485	Target Neighborhood Hits	976	Shared Neighborhood Hits	63
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

SREC2_MOUSE
NC score	0.051846 (rank : 784)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	485	Target Neighborhood Hits	605	Shared Neighborhood Hits	42
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

E2AK2_MOUSE
NC score	0.051814 (rank : 785)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	485	Target Neighborhood Hits	864	Shared Neighborhood Hits	84
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

ULK3_HUMAN
NC score	0.051603 (rank : 786)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	485	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

MAK_MOUSE
NC score	0.051592 (rank : 787)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	485	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

STK39_MOUSE
NC score	0.051468 (rank : 788)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	485	Target Neighborhood Hits	915	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK39_HUMAN
NC score	0.051322 (rank : 789)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	485	Target Neighborhood Hits	882	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

NEK1_MOUSE
NC score	0.051312 (rank : 790)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	485	Target Neighborhood Hits	1311	Shared Neighborhood Hits	90
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

CDK4_MOUSE
NC score	0.051250 (rank : 791)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	485	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

MAK_HUMAN
NC score	0.051212 (rank : 792)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	485	Target Neighborhood Hits	857	Shared Neighborhood Hits	83
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

WIF1_MOUSE
NC score	0.051187 (rank : 793)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	485	Target Neighborhood Hits	393	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

ULK2_HUMAN
NC score	0.051173 (rank : 794)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	485	Target Neighborhood Hits	979	Shared Neighborhood Hits	91
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

STK36_HUMAN
NC score	0.051155 (rank : 795)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	485	Target Neighborhood Hits	896	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

OXSR1_HUMAN
NC score	0.051129 (rank : 796)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

AVR2A_MOUSE
NC score	0.051119 (rank : 797)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	485	Target Neighborhood Hits	767	Shared Neighborhood Hits	80
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

I13R1_MOUSE
NC score	0.051119 (rank : 798)	θ value	0.000786445 (rank : 304)
Query Neighborhood Hits	485	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	O09030, Q7TT27	Gene names	Il13ra1, Il13r, Il13ra
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-1 chain precursor (IL-13R-alpha-1) (IL- 13RA-1) (Interleukin-13-binding protein) (NR4) (CD213a1 antigen).

AVR2A_HUMAN
NC score	0.051117 (rank : 799)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	485	Target Neighborhood Hits	767	Shared Neighborhood Hits	80
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

ULK1_MOUSE
NC score	0.051071 (rank : 800)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	485	Target Neighborhood Hits	1214	Shared Neighborhood Hits	96
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK1_HUMAN
NC score	0.051007 (rank : 801)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	485	Target Neighborhood Hits	1121	Shared Neighborhood Hits	90
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

PLK4_HUMAN
NC score	0.050946 (rank : 802)	θ value	8.99809 (rank : 479)
Query Neighborhood Hits	485	Target Neighborhood Hits	884	Shared Neighborhood Hits	86
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KS6A3_HUMAN
NC score	0.050882 (rank : 803)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	485	Target Neighborhood Hits	859	Shared Neighborhood Hits	84
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PLK4_MOUSE
NC score	0.050864 (rank : 804)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	485	Target Neighborhood Hits	879	Shared Neighborhood Hits	84
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KS6A3_MOUSE
NC score	0.050844 (rank : 805)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	485	Target Neighborhood Hits	860	Shared Neighborhood Hits	84
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

FCG2A_HUMAN
NC score	0.050817 (rank : 806)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	485	Target Neighborhood Hits	92	Shared Neighborhood Hits	53
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

OXSR1_MOUSE
NC score	0.050811 (rank : 807)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	485	Target Neighborhood Hits	865	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ICK_HUMAN
NC score	0.050807 (rank : 808)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	485	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ULK2_MOUSE
NC score	0.050789 (rank : 809)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	485	Target Neighborhood Hits	943	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

NEK3_HUMAN
NC score	0.050713 (rank : 810)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	485	Target Neighborhood Hits	865	Shared Neighborhood Hits	84
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

LAMA5_MOUSE
NC score	0.050634 (rank : 811)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	485	Target Neighborhood Hits	828	Shared Neighborhood Hits	61
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

ICK_MOUSE
NC score	0.050573 (rank : 812)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	485	Target Neighborhood Hits	860	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

NUAK2_HUMAN
NC score	0.050543 (rank : 813)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	485	Target Neighborhood Hits	874	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

PAK6_HUMAN
NC score	0.050475 (rank : 814)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	485	Target Neighborhood Hits	915	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

KRA51_HUMAN
NC score	0.050357 (rank : 815)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	485	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KS6A2_HUMAN
NC score	0.050334 (rank : 816)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	485	Target Neighborhood Hits	857	Shared Neighborhood Hits	84
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

NEK3_MOUSE
NC score	0.050303 (rank : 817)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	485	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

CD2L7_HUMAN
NC score	0.050299 (rank : 818)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	485	Target Neighborhood Hits	1275	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CNTFR_HUMAN
NC score	0.050279 (rank : 819)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	485	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

ANGL6_MOUSE
NC score	0.050260 (rank : 820)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	485	Target Neighborhood Hits	63	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R0Z6	Gene names	Angptl6, Agf
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 6 precursor (Angiopoietin-like 6) (Angiopoietin-related growth factor).

CDK6_MOUSE
NC score	0.050153 (rank : 821)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	485	Target Neighborhood Hits	837	Shared Neighborhood Hits	84
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

KS6A1_HUMAN
NC score	0.050092 (rank : 822)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	485	Target Neighborhood Hits	854	Shared Neighborhood Hits	84
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

BT3A3_HUMAN
NC score	0.049928 (rank : 823)	θ value	1.81305 (rank : 425)
Query Neighborhood Hits	485	Target Neighborhood Hits	233	Shared Neighborhood Hits	85
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

BT3A1_HUMAN
NC score	0.047832 (rank : 824)	θ value	2.36792 (rank : 431)
Query Neighborhood Hits	485	Target Neighborhood Hits	229	Shared Neighborhood Hits	80
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

TRI42_HUMAN
NC score	0.044671 (rank : 825)	θ value	8.99809 (rank : 485)
Query Neighborhood Hits	485	Target Neighborhood Hits	283	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

MUC_MOUSE
NC score	0.041251 (rank : 826)	θ value	0.813845 (rank : 407)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

MUCM_MOUSE
NC score	0.040796 (rank : 827)	θ value	0.813845 (rank : 406)
Query Neighborhood Hits	485	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

JAG1_MOUSE
NC score	0.038553 (rank : 828)	θ value	2.36792 (rank : 435)
Query Neighborhood Hits	485	Target Neighborhood Hits	518	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

INAR1_HUMAN
NC score	0.037881 (rank : 829)	θ value	0.47712 (rank : 396)
Query Neighborhood Hits	485	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	P17181, Q53GW9, Q53H11, Q8WTZ2	Gene names	IFNAR1, IFNAR
Domain Architecture	No domain graphic available
Description	Interferon-alpha/beta receptor alpha chain precursor (IFN-alpha-REC).

MUC_HUMAN
NC score	0.036402 (rank : 830)	θ value	0.00869519 (rank : 333)
Query Neighborhood Hits	485	Target Neighborhood Hits	231	Shared Neighborhood Hits	31
SwissProt Accessions	P01871	Gene names	IGHM
Domain Architecture
Description	Ig mu chain C region.

IL18R_HUMAN
NC score	0.035321 (rank : 831)	θ value	1.06291 (rank : 412)
Query Neighborhood Hits	485	Target Neighborhood Hits	81	Shared Neighborhood Hits	34
SwissProt Accessions	Q13478	Gene names	IL18R1, IL1RRP
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp) (CDw218a antigen).

TRI18_HUMAN
NC score	0.034582 (rank : 832)	θ value	0.279714 (rank : 387)
Query Neighborhood Hits	485	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

DUS11_MOUSE
NC score	0.034488 (rank : 833)	θ value	3.0926 (rank : 439)
Query Neighborhood Hits	485	Target Neighborhood Hits	41	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

TRIM1_MOUSE
NC score	0.033995 (rank : 834)	θ value	0.163984 (rank : 381)
Query Neighborhood Hits	485	Target Neighborhood Hits	361	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

RIMB1_HUMAN
NC score	0.033912 (rank : 835)	θ value	0.279714 (rank : 386)
Query Neighborhood Hits	485	Target Neighborhood Hits	1479	Shared Neighborhood Hits	46
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MUCB_HUMAN
NC score	0.032777 (rank : 836)	θ value	0.163984 (rank : 380)
Query Neighborhood Hits	485	Target Neighborhood Hits	233	Shared Neighborhood Hits	33
SwissProt Accessions	P04220	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu heavy chain disease protein (BOT).

GHR_HUMAN
NC score	0.031186 (rank : 837)	θ value	1.06291 (rank : 410)
Query Neighborhood Hits	485	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	P10912, Q9HCX2	Gene names	GHR
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

FANK1_MOUSE
NC score	0.028480 (rank : 838)	θ value	0.813845 (rank : 404)
Query Neighborhood Hits	485	Target Neighborhood Hits	325	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

IL4RA_HUMAN
NC score	0.027359 (rank : 839)	θ value	1.38821 (rank : 416)
Query Neighborhood Hits	485	Target Neighborhood Hits	144	Shared Neighborhood Hits	22
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

FANK1_HUMAN
NC score	0.027073 (rank : 840)	θ value	2.36792 (rank : 434)
Query Neighborhood Hits	485	Target Neighborhood Hits	326	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

LRP10_HUMAN
NC score	0.025414 (rank : 841)	θ value	4.03905 (rank : 446)
Query Neighborhood Hits	485	Target Neighborhood Hits	197	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

DUS11_HUMAN
NC score	0.024332 (rank : 842)	θ value	6.88961 (rank : 454)
Query Neighborhood Hits	485	Target Neighborhood Hits	37	Shared Neighborhood Hits	18
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

UROL1_MOUSE
NC score	0.023749 (rank : 843)	θ value	3.0926 (rank : 444)
Query Neighborhood Hits	485	Target Neighborhood Hits	235	Shared Neighborhood Hits	26
SwissProt Accessions	Q5DID3, Q5DID1, Q5DID2	Gene names	Umodl1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

IGHA_MOUSE
NC score	0.023542 (rank : 844)	θ value	1.06291 (rank : 411)
Query Neighborhood Hits	485	Target Neighborhood Hits	196	Shared Neighborhood Hits	19
SwissProt Accessions	P01878	Gene names
Domain Architecture
Description	Ig alpha chain C region.

TRI36_MOUSE
NC score	0.021861 (rank : 845)	θ value	8.99809 (rank : 484)
Query Neighborhood Hits	485	Target Neighborhood Hits	266	Shared Neighborhood Hits	39
SwissProt Accessions	Q80WG7, Q7TNM1	Gene names	Trim36
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Haprin) (Acrosome RBCC protein).

TRI18_MOUSE
NC score	0.021829 (rank : 846)	θ value	8.99809 (rank : 482)
Query Neighborhood Hits	485	Target Neighborhood Hits	292	Shared Neighborhood Hits	34
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

GHR_MOUSE
NC score	0.021144 (rank : 847)	θ value	8.99809 (rank : 469)
Query Neighborhood Hits	485	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	P16882, P16590, Q61653, Q6DI66, Q80W86, Q8R1M5, Q920Z3, Q9R264	Gene names	Ghr
Domain Architecture
Description	Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)].

SHD_HUMAN
NC score	0.021057 (rank : 848)	θ value	4.03905 (rank : 448)
Query Neighborhood Hits	485	Target Neighborhood Hits	204	Shared Neighborhood Hits	9
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

RIMB1_MOUSE
NC score	0.020720 (rank : 849)	θ value	4.03905 (rank : 447)
Query Neighborhood Hits	485	Target Neighborhood Hits	1376	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SEM3C_MOUSE
NC score	0.020646 (rank : 850)	θ value	8.99809 (rank : 481)
Query Neighborhood Hits	485	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

I28RA_HUMAN
NC score	0.020201 (rank : 851)	θ value	6.88961 (rank : 455)
Query Neighborhood Hits	485	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IU57, Q6ZML8, Q8IZI7, Q8IZI8	Gene names	IL28RA, IFNLR1, LICR2
Domain Architecture	No domain graphic available
Description	Interleukin-28 receptor alpha chain precursor (IL-28R-alpha) (IL-28RA) (Cytokine receptor family 2 member 12) (Cytokine receptor class-II member 12) (CRF2-12) (Interferon lambda receptor 1) (IFN-lambda R1) (Likely interleukin or cytokine receptor 2).

IL5RA_HUMAN
NC score	0.019735 (rank : 852)	θ value	3.0926 (rank : 441)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	16
SwissProt Accessions	Q01344, Q6ISX9	Gene names	IL5RA, IL5R
Domain Architecture	No domain graphic available
Description	Interleukin-5 receptor alpha chain precursor (IL-5R-alpha) (CD125 antigen) (CDw125).

PCLO_MOUSE
NC score	0.019328 (rank : 853)	θ value	5.27518 (rank : 451)
Query Neighborhood Hits	485	Target Neighborhood Hits	2275	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

DUS13_HUMAN
NC score	0.018066 (rank : 854)	θ value	1.81305 (rank : 427)
Query Neighborhood Hits	485	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UII6, Q5JSC6, Q96GC2	Gene names	DUSP13, TMDP
Domain Architecture
Description	Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal-muscle-specific DSP) (Dual specificity phosphatase SKRP4).

HUG1_HUMAN
NC score	0.017059 (rank : 855)	θ value	0.62314 (rank : 400)
Query Neighborhood Hits	485	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O75698	Gene names	HUG1, C10orf1
Domain Architecture	No domain graphic available
Description	Protein HUG-1 (HOX11 upstream gene 1 protein).

TRI36_HUMAN
NC score	0.015261 (rank : 856)	θ value	8.99809 (rank : 483)
Query Neighborhood Hits	485	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ86	Gene names	TRIM36, RBCC728, RNF98
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Zinc-binding protein Rbcc728) (RING finger protein 98).

RTBDN_MOUSE
NC score	0.015128 (rank : 857)	θ value	1.81305 (rank : 430)
Query Neighborhood Hits	485	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q8QZY4, Q6T898	Gene names	Rtbdn
Domain Architecture	No domain graphic available
Description	Retbindin precursor.

GGA1_HUMAN
NC score	0.014909 (rank : 858)	θ value	0.21417 (rank : 382)
Query Neighborhood Hits	485	Target Neighborhood Hits	169	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

ZFN2B_HUMAN
NC score	0.014217 (rank : 859)	θ value	6.88961 (rank : 465)
Query Neighborhood Hits	485	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WV99, Q8NB98	Gene names	ZFAND2B
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 2B.

ASM3A_HUMAN
NC score	0.013538 (rank : 860)	θ value	1.06291 (rank : 409)
Query Neighborhood Hits	485	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q92484, Q8WV13	Gene names	SMPDL3A, ASML3A
Domain Architecture	No domain graphic available
Description	Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a).

MAML3_HUMAN
NC score	0.012712 (rank : 861)	θ value	8.99809 (rank : 475)
Query Neighborhood Hits	485	Target Neighborhood Hits	323	Shared Neighborhood Hits	18
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

TBC19_HUMAN
NC score	0.012072 (rank : 862)	θ value	1.38821 (rank : 420)
Query Neighborhood Hits	485	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5T2	Gene names	TBC1D19
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 19.

K0889_HUMAN
NC score	0.011998 (rank : 863)	θ value	1.81305 (rank : 429)
Query Neighborhood Hits	485	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	O94964	Gene names	KIAA0889
Domain Architecture	No domain graphic available
Description	Protein KIAA0889.

DUS12_MOUSE
NC score	0.011517 (rank : 864)	θ value	2.36792 (rank : 433)
Query Neighborhood Hits	485	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D0T2, Q9EQD3	Gene names	Dusp12
Domain Architecture
Description	Dual specificity protein phosphatase 12 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1).

CELR3_HUMAN
NC score	0.010909 (rank : 865)	θ value	8.99809 (rank : 466)
Query Neighborhood Hits	485	Target Neighborhood Hits	680	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

GC3M_MOUSE
NC score	0.010846 (rank : 866)	θ value	8.99809 (rank : 467)
Query Neighborhood Hits	485	Target Neighborhood Hits	215	Shared Neighborhood Hits	19
SwissProt Accessions	P03987	Gene names
Domain Architecture
Description	Ig gamma-3 chain C region, membrane-bound form.

GC3_MOUSE
NC score	0.010737 (rank : 867)	θ value	8.99809 (rank : 468)
Query Neighborhood Hits	485	Target Neighborhood Hits	212	Shared Neighborhood Hits	18
SwissProt Accessions	P22436	Gene names
Domain Architecture	No domain graphic available
Description	Ig gamma-3 chain C region, secreted form.

GPR98_HUMAN
NC score	0.009181 (rank : 868)	θ value	5.27518 (rank : 450)
Query Neighborhood Hits	485	Target Neighborhood Hits	202	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

TDRD6_MOUSE
NC score	0.008298 (rank : 869)	θ value	3.0926 (rank : 443)
Query Neighborhood Hits	485	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

MED12_HUMAN
NC score	0.006594 (rank : 870)	θ value	1.38821 (rank : 417)
Query Neighborhood Hits	485	Target Neighborhood Hits	262	Shared Neighborhood Hits	7
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

PCLO_HUMAN
NC score	0.006037 (rank : 871)	θ value	6.88961 (rank : 458)
Query Neighborhood Hits	485	Target Neighborhood Hits	2046	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PRP8_MOUSE
NC score	0.005982 (rank : 872)	θ value	6.88961 (rank : 461)
Query Neighborhood Hits	485	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q99PV0, Q5ND30, Q5ND31, Q7TQK2, Q8BRZ5, Q8K001	Gene names	Prpf8, Prp8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8).

PRP8_HUMAN
NC score	0.005974 (rank : 873)	θ value	6.88961 (rank : 460)
Query Neighborhood Hits	485	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P2Q9, O14547, O75965	Gene names	PRPF8, PRPC8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) (PRP8 homolog) (220 kDa U5 snRNP-specific protein) (p220).

NALP1_HUMAN
NC score	0.003355 (rank : 874)	θ value	0.813845 (rank : 408)
Query Neighborhood Hits	485	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

CN092_HUMAN
NC score	0.003313 (rank : 875)	θ value	2.36792 (rank : 432)
Query Neighborhood Hits	485	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	O94842	Gene names	C14orf92, KIAA0737
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

EP400_MOUSE
NC score	0.002856 (rank : 876)	θ value	0.47712 (rank : 395)
Query Neighborhood Hits	485	Target Neighborhood Hits	592	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

ECM29_MOUSE
NC score	0.002752 (rank : 877)	θ value	5.27518 (rank : 449)
Query Neighborhood Hits	485	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

MAGD1_MOUSE
NC score	0.001718 (rank : 878)	θ value	8.99809 (rank : 474)
Query Neighborhood Hits	485	Target Neighborhood Hits	136	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

MYO15_MOUSE
NC score	0.001093 (rank : 879)	θ value	8.99809 (rank : 476)
Query Neighborhood Hits	485	Target Neighborhood Hits	467	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

TNR1A_HUMAN
NC score	0.000798 (rank : 880)	θ value	6.88961 (rank : 464)
Query Neighborhood Hits	485	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

ITIH1_MOUSE
NC score	0.000515 (rank : 881)	θ value	8.99809 (rank : 472)
Query Neighborhood Hits	485	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

MAGD1_HUMAN
NC score	-0.000860 (rank : 882)	θ value	8.99809 (rank : 473)
Query Neighborhood Hits	485	Target Neighborhood Hits	130	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

MYC_MOUSE
NC score	-0.000931 (rank : 883)	θ value	6.88961 (rank : 456)
Query Neighborhood Hits	485	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).