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Network neighborhood for query Sequence : SDK2_HUMAN

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SDK2_HUMAN
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SDK1_HUMAN
θ value	0 (rank : 1)	NC score	0.985948 (rank : 4)
Query Neighborhood Hits	495	Target Neighborhood Hits	511	Shared Neighborhood Hits	410
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
θ value	0 (rank : 2)	NC score	0.986379 (rank : 3)
Query Neighborhood Hits	495	Target Neighborhood Hits	495	Shared Neighborhood Hits	410
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	495	Target Neighborhood Hits	495	Shared Neighborhood Hits	495
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	0 (rank : 4)	NC score	0.996449 (rank : 2)
Query Neighborhood Hits	495	Target Neighborhood Hits	480	Shared Neighborhood Hits	447
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CNTN3_HUMAN
θ value	1.14559e-87 (rank : 5)	NC score	0.918064 (rank : 13)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	390
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

DSCL1_HUMAN
θ value	3.33315e-87 (rank : 6)	NC score	0.936214 (rank : 5)
Query Neighborhood Hits	495	Target Neighborhood Hits	589	Shared Neighborhood Hits	410
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DSCAM_HUMAN
θ value	8.20983e-86 (rank : 7)	NC score	0.934649 (rank : 6)
Query Neighborhood Hits	495	Target Neighborhood Hits	524	Shared Neighborhood Hits	397
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

CNTN3_MOUSE
θ value	5.50685e-82 (rank : 8)	NC score	0.913300 (rank : 18)
Query Neighborhood Hits	495	Target Neighborhood Hits	447	Shared Neighborhood Hits	387
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN6_HUMAN
θ value	1.77149e-80 (rank : 9)	NC score	0.902420 (rank : 28)
Query Neighborhood Hits	495	Target Neighborhood Hits	422	Shared Neighborhood Hits	362
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN4_HUMAN
θ value	8.79181e-80 (rank : 10)	NC score	0.905449 (rank : 25)
Query Neighborhood Hits	495	Target Neighborhood Hits	449	Shared Neighborhood Hits	369
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN6_MOUSE
θ value	1.26953e-78 (rank : 11)	NC score	0.901134 (rank : 30)
Query Neighborhood Hits	495	Target Neighborhood Hits	429	Shared Neighborhood Hits	370
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CNTN4_MOUSE
θ value	4.82422e-78 (rank : 12)	NC score	0.905538 (rank : 24)
Query Neighborhood Hits	495	Target Neighborhood Hits	445	Shared Neighborhood Hits	371
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

PTPRF_HUMAN
θ value	4.99229e-75 (rank : 13)	NC score	0.740302 (rank : 68)
Query Neighborhood Hits	495	Target Neighborhood Hits	489	Shared Neighborhood Hits	370
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRD_HUMAN
θ value	5.51964e-74 (rank : 14)	NC score	0.733094 (rank : 71)
Query Neighborhood Hits	495	Target Neighborhood Hits	485	Shared Neighborhood Hits	365
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CNTN2_HUMAN
θ value	2.73936e-73 (rank : 15)	NC score	0.918440 (rank : 12)
Query Neighborhood Hits	495	Target Neighborhood Hits	440	Shared Neighborhood Hits	386
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
θ value	1.27248e-70 (rank : 16)	NC score	0.916481 (rank : 17)
Query Neighborhood Hits	495	Target Neighborhood Hits	450	Shared Neighborhood Hits	380
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN5_HUMAN
θ value	2.17053e-70 (rank : 17)	NC score	0.911839 (rank : 19)
Query Neighborhood Hits	495	Target Neighborhood Hits	446	Shared Neighborhood Hits	383
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

PTPRS_HUMAN
θ value	9.11921e-69 (rank : 18)	NC score	0.723001 (rank : 76)
Query Neighborhood Hits	495	Target Neighborhood Hits	472	Shared Neighborhood Hits	359
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

CHL1_HUMAN
θ value	3.4653e-68 (rank : 19)	NC score	0.911064 (rank : 20)
Query Neighborhood Hits	495	Target Neighborhood Hits	413	Shared Neighborhood Hits	365
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

NRCAM_MOUSE
θ value	7.71989e-68 (rank : 20)	NC score	0.922394 (rank : 11)
Query Neighborhood Hits	495	Target Neighborhood Hits	432	Shared Neighborhood Hits	367
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

CNTN5_MOUSE
θ value	1.00825e-67 (rank : 21)	NC score	0.908160 (rank : 21)
Query Neighborhood Hits	495	Target Neighborhood Hits	434	Shared Neighborhood Hits	372
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

CHL1_MOUSE
θ value	1.90147e-66 (rank : 22)	NC score	0.902045 (rank : 29)
Query Neighborhood Hits	495	Target Neighborhood Hits	402	Shared Neighborhood Hits	357
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

DCC_MOUSE
θ value	1.04338e-64 (rank : 23)	NC score	0.905583 (rank : 23)
Query Neighborhood Hits	495	Target Neighborhood Hits	896	Shared Neighborhood Hits	406
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

L1CAM_MOUSE
θ value	3.96481e-64 (rank : 24)	NC score	0.916684 (rank : 16)
Query Neighborhood Hits	495	Target Neighborhood Hits	457	Shared Neighborhood Hits	382
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NRCAM_HUMAN
θ value	3.96481e-64 (rank : 25)	NC score	0.923692 (rank : 10)
Query Neighborhood Hits	495	Target Neighborhood Hits	439	Shared Neighborhood Hits	379
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

DCC_HUMAN
θ value	5.17823e-64 (rank : 26)	NC score	0.924106 (rank : 9)
Query Neighborhood Hits	495	Target Neighborhood Hits	583	Shared Neighborhood Hits	404
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

NFASC_HUMAN
θ value	9.76566e-63 (rank : 27)	NC score	0.917888 (rank : 15)
Query Neighborhood Hits	495	Target Neighborhood Hits	497	Shared Neighborhood Hits	383
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

L1CAM_HUMAN
θ value	2.84138e-62 (rank : 28)	NC score	0.917942 (rank : 14)
Query Neighborhood Hits	495	Target Neighborhood Hits	457	Shared Neighborhood Hits	382
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN1_HUMAN
θ value	8.26713e-62 (rank : 29)	NC score	0.904450 (rank : 27)
Query Neighborhood Hits	495	Target Neighborhood Hits	431	Shared Neighborhood Hits	366
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
θ value	2.40537e-61 (rank : 30)	NC score	0.904960 (rank : 26)
Query Neighborhood Hits	495	Target Neighborhood Hits	422	Shared Neighborhood Hits	367
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

PTPRD_MOUSE
θ value	1.19377e-60 (rank : 31)	NC score	0.744063 (rank : 65)
Query Neighborhood Hits	495	Target Neighborhood Hits	491	Shared Neighborhood Hits	373
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

NEO1_HUMAN
θ value	2.03627e-60 (rank : 32)	NC score	0.927547 (rank : 7)
Query Neighborhood Hits	495	Target Neighborhood Hits	530	Shared Neighborhood Hits	395
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

ROBO2_HUMAN
θ value	1.0458e-56 (rank : 33)	NC score	0.896053 (rank : 31)
Query Neighborhood Hits	495	Target Neighborhood Hits	479	Shared Neighborhood Hits	393
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

NEO1_MOUSE
θ value	6.77864e-56 (rank : 34)	NC score	0.924526 (rank : 8)
Query Neighborhood Hits	495	Target Neighborhood Hits	523	Shared Neighborhood Hits	390
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

TITIN_HUMAN
θ value	6.77864e-56 (rank : 35)	NC score	0.557133 (rank : 142)
Query Neighborhood Hits	495	Target Neighborhood Hits	2923	Shared Neighborhood Hits	456
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ROBO2_MOUSE
θ value	4.85792e-54 (rank : 36)	NC score	0.894557 (rank : 33)
Query Neighborhood Hits	495	Target Neighborhood Hits	504	Shared Neighborhood Hits	401
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_HUMAN
θ value	2.41096e-53 (rank : 37)	NC score	0.892459 (rank : 34)
Query Neighborhood Hits	495	Target Neighborhood Hits	570	Shared Neighborhood Hits	386
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ROBO1_HUMAN
θ value	3.1488e-53 (rank : 38)	NC score	0.881043 (rank : 38)
Query Neighborhood Hits	495	Target Neighborhood Hits	529	Shared Neighborhood Hits	383
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

NFASC_MOUSE
θ value	2.49495e-50 (rank : 39)	NC score	0.907386 (rank : 22)
Query Neighborhood Hits	495	Target Neighborhood Hits	475	Shared Neighborhood Hits	376
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

ROBO1_MOUSE
θ value	7.25919e-50 (rank : 40)	NC score	0.885223 (rank : 37)
Query Neighborhood Hits	495	Target Neighborhood Hits	559	Shared Neighborhood Hits	391
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

USH2A_HUMAN
θ value	1.23823e-49 (rank : 41)	NC score	0.468003 (rank : 164)
Query Neighborhood Hits	495	Target Neighborhood Hits	600	Shared Neighborhood Hits	185
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

HMCN1_HUMAN
θ value	8.87376e-48 (rank : 42)	NC score	0.605399 (rank : 118)
Query Neighborhood Hits	495	Target Neighborhood Hits	983	Shared Neighborhood Hits	357
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

ROBO3_MOUSE
θ value	1.97686e-47 (rank : 43)	NC score	0.887743 (rank : 36)
Query Neighborhood Hits	495	Target Neighborhood Hits	524	Shared Neighborhood Hits	377
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

USH2A_MOUSE
θ value	5.03882e-43 (rank : 44)	NC score	0.451995 (rank : 170)
Query Neighborhood Hits	495	Target Neighborhood Hits	626	Shared Neighborhood Hits	179
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

PUNC_HUMAN
θ value	1.51715e-39 (rank : 45)	NC score	0.894928 (rank : 32)
Query Neighborhood Hits	495	Target Neighborhood Hits	449	Shared Neighborhood Hits	346
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
θ value	2.58786e-39 (rank : 46)	NC score	0.888286 (rank : 35)
Query Neighborhood Hits	495	Target Neighborhood Hits	501	Shared Neighborhood Hits	339
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PTK7_HUMAN
θ value	7.04741e-37 (rank : 47)	NC score	0.498645 (rank : 155)
Query Neighborhood Hits	495	Target Neighborhood Hits	1103	Shared Neighborhood Hits	345
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

FINC_MOUSE
θ value	3.4976e-36 (rank : 48)	NC score	0.605706 (rank : 117)
Query Neighborhood Hits	495	Target Neighborhood Hits	309	Shared Neighborhood Hits	181
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

CDON_MOUSE
θ value	1.01765e-35 (rank : 49)	NC score	0.867241 (rank : 40)
Query Neighborhood Hits	495	Target Neighborhood Hits	410	Shared Neighborhood Hits	341
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

NCA12_MOUSE
θ value	6.59618e-35 (rank : 50)	NC score	0.819943 (rank : 46)
Query Neighborhood Hits	495	Target Neighborhood Hits	399	Shared Neighborhood Hits	338
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCA11_MOUSE
θ value	8.61488e-35 (rank : 51)	NC score	0.809517 (rank : 48)
Query Neighborhood Hits	495	Target Neighborhood Hits	661	Shared Neighborhood Hits	357
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CDON_HUMAN
θ value	1.9192e-34 (rank : 52)	NC score	0.867661 (rank : 39)
Query Neighborhood Hits	495	Target Neighborhood Hits	412	Shared Neighborhood Hits	339
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

BOC_MOUSE
θ value	9.52487e-34 (rank : 53)	NC score	0.857668 (rank : 42)
Query Neighborhood Hits	495	Target Neighborhood Hits	433	Shared Neighborhood Hits	344
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

PGBM_HUMAN
θ value	3.61944e-33 (rank : 54)	NC score	0.612972 (rank : 114)
Query Neighborhood Hits	495	Target Neighborhood Hits	1113	Shared Neighborhood Hits	363
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

FINC_HUMAN
θ value	4.72714e-33 (rank : 55)	NC score	0.598411 (rank : 122)
Query Neighborhood Hits	495	Target Neighborhood Hits	302	Shared Neighborhood Hits	190
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

NCA11_HUMAN
θ value	4.72714e-33 (rank : 56)	NC score	0.826428 (rank : 45)
Query Neighborhood Hits	495	Target Neighborhood Hits	443	Shared Neighborhood Hits	361
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

BOC_HUMAN
θ value	8.06329e-33 (rank : 57)	NC score	0.859718 (rank : 41)
Query Neighborhood Hits	495	Target Neighborhood Hits	543	Shared Neighborhood Hits	356
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCAM2_MOUSE
θ value	1.16434e-31 (rank : 58)	NC score	0.855590 (rank : 43)
Query Neighborhood Hits	495	Target Neighborhood Hits	472	Shared Neighborhood Hits	384
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCA12_HUMAN
θ value	3.3877e-31 (rank : 59)	NC score	0.818254 (rank : 47)
Query Neighborhood Hits	495	Target Neighborhood Hits	437	Shared Neighborhood Hits	356
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

MYOM2_HUMAN
θ value	8.3442e-30 (rank : 60)	NC score	0.791097 (rank : 50)
Query Neighborhood Hits	495	Target Neighborhood Hits	341	Shared Neighborhood Hits	305
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOM1_HUMAN
θ value	3.50572e-28 (rank : 61)	NC score	0.785569 (rank : 53)
Query Neighborhood Hits	495	Target Neighborhood Hits	405	Shared Neighborhood Hits	312
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

FNDC3_MOUSE
θ value	5.97985e-28 (rank : 62)	NC score	0.727533 (rank : 73)
Query Neighborhood Hits	495	Target Neighborhood Hits	207	Shared Neighborhood Hits	176
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

PGBM_MOUSE
θ value	2.96777e-27 (rank : 63)	NC score	0.598218 (rank : 123)
Query Neighborhood Hits	495	Target Neighborhood Hits	1073	Shared Neighborhood Hits	357
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

NCAM2_HUMAN
θ value	6.61148e-27 (rank : 64)	NC score	0.846089 (rank : 44)
Query Neighborhood Hits	495	Target Neighborhood Hits	441	Shared Neighborhood Hits	375
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

MUSK_HUMAN
θ value	2.77775e-25 (rank : 65)	NC score	0.456547 (rank : 168)
Query Neighborhood Hits	495	Target Neighborhood Hits	1074	Shared Neighborhood Hits	331
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

COCA1_MOUSE
θ value	3.62785e-25 (rank : 66)	NC score	0.474135 (rank : 163)
Query Neighborhood Hits	495	Target Neighborhood Hits	467	Shared Neighborhood Hits	178
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

FNDC3_HUMAN
θ value	3.62785e-25 (rank : 67)	NC score	0.727079 (rank : 74)
Query Neighborhood Hits	495	Target Neighborhood Hits	196	Shared Neighborhood Hits	173
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

MUSK_MOUSE
θ value	4.73814e-25 (rank : 68)	NC score	0.457192 (rank : 167)
Query Neighborhood Hits	495	Target Neighborhood Hits	1057	Shared Neighborhood Hits	330
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

COCA1_HUMAN
θ value	6.18819e-25 (rank : 69)	NC score	0.458261 (rank : 166)
Query Neighborhood Hits	495	Target Neighborhood Hits	458	Shared Neighborhood Hits	169
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

CO7A1_HUMAN
θ value	1.37858e-24 (rank : 70)	NC score	0.334313 (rank : 245)
Query Neighborhood Hits	495	Target Neighborhood Hits	807	Shared Neighborhood Hits	168
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

MYOM1_MOUSE
θ value	1.29031e-22 (rank : 71)	NC score	0.773718 (rank : 57)
Query Neighborhood Hits	495	Target Neighborhood Hits	415	Shared Neighborhood Hits	329
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

TENR_HUMAN
θ value	2.87452e-22 (rank : 72)	NC score	0.383083 (rank : 202)
Query Neighborhood Hits	495	Target Neighborhood Hits	526	Shared Neighborhood Hits	165
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

TENR_MOUSE
θ value	2.87452e-22 (rank : 73)	NC score	0.372989 (rank : 211)
Query Neighborhood Hits	495	Target Neighborhood Hits	531	Shared Neighborhood Hits	161
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

TENN_MOUSE
θ value	1.86321e-21 (rank : 74)	NC score	0.384845 (rank : 199)
Query Neighborhood Hits	495	Target Neighborhood Hits	484	Shared Neighborhood Hits	156
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

MYLK_HUMAN
θ value	3.17815e-21 (rank : 75)	NC score	0.388785 (rank : 194)
Query Neighborhood Hits	495	Target Neighborhood Hits	1328	Shared Neighborhood Hits	355
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

ROBO4_MOUSE
θ value	2.06002e-20 (rank : 76)	NC score	0.792608 (rank : 49)
Query Neighborhood Hits	495	Target Neighborhood Hits	358	Shared Neighborhood Hits	272
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

LRIG2_MOUSE
θ value	7.82807e-20 (rank : 77)	NC score	0.580695 (rank : 130)
Query Neighborhood Hits	495	Target Neighborhood Hits	586	Shared Neighborhood Hits	306
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

OBSCN_HUMAN
θ value	1.02238e-19 (rank : 78)	NC score	0.403845 (rank : 186)
Query Neighborhood Hits	495	Target Neighborhood Hits	1931	Shared Neighborhood Hits	387
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

MYLK_MOUSE
θ value	5.07402e-19 (rank : 79)	NC score	0.385856 (rank : 198)
Query Neighborhood Hits	495	Target Neighborhood Hits	1489	Shared Neighborhood Hits	357
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

LRIG2_HUMAN
θ value	1.13037e-18 (rank : 80)	NC score	0.582885 (rank : 129)
Query Neighborhood Hits	495	Target Neighborhood Hits	595	Shared Neighborhood Hits	306
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

ROBO4_HUMAN
θ value	2.5182e-18 (rank : 81)	NC score	0.788909 (rank : 52)
Query Neighborhood Hits	495	Target Neighborhood Hits	364	Shared Neighborhood Hits	273
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

MYPC2_HUMAN
θ value	4.29542e-18 (rank : 82)	NC score	0.700551 (rank : 80)
Query Neighborhood Hits	495	Target Neighborhood Hits	316	Shared Neighborhood Hits	284
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC2_MOUSE
θ value	4.29542e-18 (rank : 83)	NC score	0.701712 (rank : 79)
Query Neighborhood Hits	495	Target Neighborhood Hits	297	Shared Neighborhood Hits	270
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

FGRL1_HUMAN
θ value	5.60996e-18 (rank : 84)	NC score	0.778290 (rank : 54)
Query Neighborhood Hits	495	Target Neighborhood Hits	335	Shared Neighborhood Hits	282
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

OBSL1_HUMAN
θ value	9.56915e-18 (rank : 85)	NC score	0.789427 (rank : 51)
Query Neighborhood Hits	495	Target Neighborhood Hits	354	Shared Neighborhood Hits	287
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

LRIG1_MOUSE
θ value	1.24977e-17 (rank : 86)	NC score	0.575248 (rank : 131)
Query Neighborhood Hits	495	Target Neighborhood Hits	627	Shared Neighborhood Hits	308
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYPN_HUMAN
θ value	2.13179e-17 (rank : 87)	NC score	0.770604 (rank : 59)
Query Neighborhood Hits	495	Target Neighborhood Hits	418	Shared Neighborhood Hits	285
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

SORL_HUMAN
θ value	4.74913e-17 (rank : 88)	NC score	0.280856 (rank : 289)
Query Neighborhood Hits	495	Target Neighborhood Hits	440	Shared Neighborhood Hits	132
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

COEA1_MOUSE
θ value	6.20254e-17 (rank : 89)	NC score	0.404392 (rank : 185)
Query Neighborhood Hits	495	Target Neighborhood Hits	402	Shared Neighborhood Hits	115
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

LRIG1_HUMAN
θ value	8.10077e-17 (rank : 90)	NC score	0.585925 (rank : 128)
Query Neighborhood Hits	495	Target Neighborhood Hits	654	Shared Neighborhood Hits	313
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MDGA1_HUMAN
θ value	8.10077e-17 (rank : 91)	NC score	0.743771 (rank : 66)
Query Neighborhood Hits	495	Target Neighborhood Hits	358	Shared Neighborhood Hits	294
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

LRIG3_MOUSE
θ value	1.058e-16 (rank : 92)	NC score	0.561445 (rank : 138)
Query Neighborhood Hits	495	Target Neighborhood Hits	611	Shared Neighborhood Hits	310
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

ITB4_HUMAN
θ value	1.38178e-16 (rank : 93)	NC score	0.427108 (rank : 175)
Query Neighborhood Hits	495	Target Neighborhood Hits	458	Shared Neighborhood Hits	160
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

KIRR1_HUMAN
θ value	1.38178e-16 (rank : 94)	NC score	0.630012 (rank : 104)
Query Neighborhood Hits	495	Target Neighborhood Hits	401	Shared Neighborhood Hits	253
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

MYPN_MOUSE
θ value	2.35696e-16 (rank : 95)	NC score	0.761001 (rank : 61)
Query Neighborhood Hits	495	Target Neighborhood Hits	421	Shared Neighborhood Hits	281
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

SPEG_HUMAN
θ value	2.35696e-16 (rank : 96)	NC score	0.374787 (rank : 209)
Query Neighborhood Hits	495	Target Neighborhood Hits	1762	Shared Neighborhood Hits	338
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

NPHN_HUMAN
θ value	4.02038e-16 (rank : 97)	NC score	0.767560 (rank : 60)
Query Neighborhood Hits	495	Target Neighborhood Hits	362	Shared Neighborhood Hits	305
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

MAMC1_HUMAN
θ value	5.25075e-16 (rank : 98)	NC score	0.753681 (rank : 62)
Query Neighborhood Hits	495	Target Neighborhood Hits	357	Shared Neighborhood Hits	293
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYPC1_HUMAN
θ value	5.25075e-16 (rank : 99)	NC score	0.692817 (rank : 82)
Query Neighborhood Hits	495	Target Neighborhood Hits	303	Shared Neighborhood Hits	277
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

LRIG3_HUMAN
θ value	6.85773e-16 (rank : 100)	NC score	0.554990 (rank : 145)
Query Neighborhood Hits	495	Target Neighborhood Hits	601	Shared Neighborhood Hits	307
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

MYOTI_HUMAN
θ value	1.99529e-15 (rank : 101)	NC score	0.775714 (rank : 55)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	264
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

SN_MOUSE
θ value	1.99529e-15 (rank : 102)	NC score	0.675686 (rank : 88)
Query Neighborhood Hits	495	Target Neighborhood Hits	416	Shared Neighborhood Hits	298
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

MAMC1_MOUSE
θ value	2.60593e-15 (rank : 103)	NC score	0.751813 (rank : 63)
Query Neighborhood Hits	495	Target Neighborhood Hits	357	Shared Neighborhood Hits	293
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

NPHN_MOUSE
θ value	2.60593e-15 (rank : 104)	NC score	0.750737 (rank : 64)
Query Neighborhood Hits	495	Target Neighborhood Hits	370	Shared Neighborhood Hits	303
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

FGRL1_MOUSE
θ value	3.40345e-15 (rank : 105)	NC score	0.771980 (rank : 58)
Query Neighborhood Hits	495	Target Neighborhood Hits	325	Shared Neighborhood Hits	287
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

KIRR1_MOUSE
θ value	3.40345e-15 (rank : 106)	NC score	0.624749 (rank : 107)
Query Neighborhood Hits	495	Target Neighborhood Hits	403	Shared Neighborhood Hits	252
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

COEA1_HUMAN
θ value	5.8054e-15 (rank : 107)	NC score	0.358358 (rank : 227)
Query Neighborhood Hits	495	Target Neighborhood Hits	427	Shared Neighborhood Hits	128
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

MYOTI_MOUSE
θ value	5.8054e-15 (rank : 108)	NC score	0.774019 (rank : 56)
Query Neighborhood Hits	495	Target Neighborhood Hits	297	Shared Neighborhood Hits	262
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

SORL_MOUSE
θ value	7.58209e-15 (rank : 109)	NC score	0.273206 (rank : 299)
Query Neighborhood Hits	495	Target Neighborhood Hits	439	Shared Neighborhood Hits	129
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SPEG_MOUSE
θ value	7.58209e-15 (rank : 110)	NC score	0.378280 (rank : 207)
Query Neighborhood Hits	495	Target Neighborhood Hits	1959	Shared Neighborhood Hits	345
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

NEGR1_HUMAN
θ value	1.29331e-14 (rank : 111)	NC score	0.733859 (rank : 70)
Query Neighborhood Hits	495	Target Neighborhood Hits	346	Shared Neighborhood Hits	289
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

TENA_HUMAN
θ value	1.68911e-14 (rank : 112)	NC score	0.292692 (rank : 279)
Query Neighborhood Hits	495	Target Neighborhood Hits	631	Shared Neighborhood Hits	158
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

MYPC3_MOUSE
θ value	2.20605e-14 (rank : 113)	NC score	0.675455 (rank : 89)
Query Neighborhood Hits	495	Target Neighborhood Hits	310	Shared Neighborhood Hits	279
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

VGFR2_MOUSE
θ value	6.41864e-14 (rank : 114)	NC score	0.391184 (rank : 192)
Query Neighborhood Hits	495	Target Neighborhood Hits	1089	Shared Neighborhood Hits	322
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

NEGR1_MOUSE
θ value	8.38298e-14 (rank : 115)	NC score	0.731757 (rank : 72)
Query Neighborhood Hits	495	Target Neighborhood Hits	349	Shared Neighborhood Hits	292
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

MYPC3_HUMAN
θ value	1.42992e-13 (rank : 116)	NC score	0.680437 (rank : 84)
Query Neighborhood Hits	495	Target Neighborhood Hits	318	Shared Neighborhood Hits	282
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

FGFR4_HUMAN
θ value	1.86753e-13 (rank : 117)	NC score	0.355404 (rank : 229)
Query Neighborhood Hits	495	Target Neighborhood Hits	1037	Shared Neighborhood Hits	301
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	4.16044e-13 (rank : 118)	NC score	0.361532 (rank : 220)
Query Neighborhood Hits	495	Target Neighborhood Hits	1026	Shared Neighborhood Hits	301
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

IL6RB_HUMAN
θ value	7.09661e-13 (rank : 119)	NC score	0.493457 (rank : 157)
Query Neighborhood Hits	495	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

SN_HUMAN
θ value	1.2105e-12 (rank : 120)	NC score	0.663838 (rank : 91)
Query Neighborhood Hits	495	Target Neighborhood Hits	434	Shared Neighborhood Hits	298
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

TYRO3_HUMAN
θ value	2.69671e-12 (rank : 121)	NC score	0.355953 (rank : 228)
Query Neighborhood Hits	495	Target Neighborhood Hits	995	Shared Neighborhood Hits	283
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

COKA1_HUMAN
θ value	3.52202e-12 (rank : 122)	NC score	0.337350 (rank : 240)
Query Neighborhood Hits	495	Target Neighborhood Hits	403	Shared Neighborhood Hits	119
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

TYRO3_MOUSE
θ value	3.52202e-12 (rank : 123)	NC score	0.353012 (rank : 231)
Query Neighborhood Hits	495	Target Neighborhood Hits	1007	Shared Neighborhood Hits	290
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

VGFR1_HUMAN
θ value	3.52202e-12 (rank : 124)	NC score	0.409778 (rank : 181)
Query Neighborhood Hits	495	Target Neighborhood Hits	1109	Shared Neighborhood Hits	329
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

FGFR3_MOUSE
θ value	4.59992e-12 (rank : 125)	NC score	0.351681 (rank : 232)
Query Neighborhood Hits	495	Target Neighborhood Hits	1059	Shared Neighborhood Hits	298
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

MERTK_HUMAN
θ value	4.59992e-12 (rank : 126)	NC score	0.321142 (rank : 256)
Query Neighborhood Hits	495	Target Neighborhood Hits	988	Shared Neighborhood Hits	270
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

ICAM5_MOUSE
θ value	6.00763e-12 (rank : 127)	NC score	0.638072 (rank : 101)
Query Neighborhood Hits	495	Target Neighborhood Hits	308	Shared Neighborhood Hits	247
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

LSAMP_MOUSE
θ value	6.00763e-12 (rank : 128)	NC score	0.741448 (rank : 67)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	298
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

MAG_MOUSE
θ value	6.00763e-12 (rank : 129)	NC score	0.679959 (rank : 85)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	252
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

EPHA7_HUMAN
θ value	1.33837e-11 (rank : 130)	NC score	0.249513 (rank : 329)
Query Neighborhood Hits	495	Target Neighborhood Hits	1053	Shared Neighborhood Hits	192
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

OPCM_HUMAN
θ value	1.33837e-11 (rank : 131)	NC score	0.726450 (rank : 75)
Query Neighborhood Hits	495	Target Neighborhood Hits	332	Shared Neighborhood Hits	291
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

TENX_HUMAN
θ value	1.74796e-11 (rank : 132)	NC score	0.290853 (rank : 280)
Query Neighborhood Hits	495	Target Neighborhood Hits	789	Shared Neighborhood Hits	165
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

VGFR1_MOUSE
θ value	1.74796e-11 (rank : 133)	NC score	0.405696 (rank : 183)
Query Neighborhood Hits	495	Target Neighborhood Hits	1118	Shared Neighborhood Hits	323
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

EPHA7_MOUSE
θ value	2.28291e-11 (rank : 134)	NC score	0.247771 (rank : 332)
Query Neighborhood Hits	495	Target Neighborhood Hits	1025	Shared Neighborhood Hits	190
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

KIRR2_HUMAN
θ value	2.28291e-11 (rank : 135)	NC score	0.675989 (rank : 87)
Query Neighborhood Hits	495	Target Neighborhood Hits	321	Shared Neighborhood Hits	249
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

ATL3_HUMAN
θ value	2.98157e-11 (rank : 136)	NC score	0.445032 (rank : 171)
Query Neighborhood Hits	495	Target Neighborhood Hits	414	Shared Neighborhood Hits	268
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

MERTK_MOUSE
θ value	2.98157e-11 (rank : 137)	NC score	0.312982 (rank : 263)
Query Neighborhood Hits	495	Target Neighborhood Hits	974	Shared Neighborhood Hits	263
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

UFO_MOUSE
θ value	2.98157e-11 (rank : 138)	NC score	0.305835 (rank : 267)
Query Neighborhood Hits	495	Target Neighborhood Hits	988	Shared Neighborhood Hits	260
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

CEAM5_HUMAN
θ value	3.89403e-11 (rank : 139)	NC score	0.609400 (rank : 116)
Query Neighborhood Hits	495	Target Neighborhood Hits	343	Shared Neighborhood Hits	275
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

CEAM1_MOUSE
θ value	6.64225e-11 (rank : 140)	NC score	0.595148 (rank : 124)
Query Neighborhood Hits	495	Target Neighborhood Hits	326	Shared Neighborhood Hits	262
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

PTPRM_HUMAN
θ value	8.67504e-11 (rank : 141)	NC score	0.370310 (rank : 212)
Query Neighborhood Hits	495	Target Neighborhood Hits	244	Shared Neighborhood Hits	163
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

FGFR3_HUMAN
θ value	1.133e-10 (rank : 142)	NC score	0.341072 (rank : 235)
Query Neighborhood Hits	495	Target Neighborhood Hits	1042	Shared Neighborhood Hits	290
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

KIRR3_HUMAN
θ value	1.47974e-10 (rank : 143)	NC score	0.628545 (rank : 106)
Query Neighborhood Hits	495	Target Neighborhood Hits	302	Shared Neighborhood Hits	244
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

EPHA5_HUMAN
θ value	1.9326e-10 (rank : 144)	NC score	0.232728 (rank : 351)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	192
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

FGFR1_HUMAN
θ value	1.9326e-10 (rank : 145)	NC score	0.346283 (rank : 233)
Query Neighborhood Hits	495	Target Neighborhood Hits	1069	Shared Neighborhood Hits	299
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	1.9326e-10 (rank : 146)	NC score	0.345508 (rank : 234)
Query Neighborhood Hits	495	Target Neighborhood Hits	1068	Shared Neighborhood Hits	298
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

I12R2_HUMAN
θ value	2.52405e-10 (rank : 147)	NC score	0.427218 (rank : 174)
Query Neighborhood Hits	495	Target Neighborhood Hits	163	Shared Neighborhood Hits	119
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

LSAMP_HUMAN
θ value	2.52405e-10 (rank : 148)	NC score	0.739415 (rank : 69)
Query Neighborhood Hits	495	Target Neighborhood Hits	347	Shared Neighborhood Hits	300
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

FGFR2_HUMAN
θ value	3.29651e-10 (rank : 149)	NC score	0.337242 (rank : 241)
Query Neighborhood Hits	495	Target Neighborhood Hits	1062	Shared Neighborhood Hits	287
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

ROR1_MOUSE
θ value	3.29651e-10 (rank : 150)	NC score	0.277168 (rank : 295)
Query Neighborhood Hits	495	Target Neighborhood Hits	1025	Shared Neighborhood Hits	261
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

UFO_HUMAN
θ value	3.29651e-10 (rank : 151)	NC score	0.298678 (rank : 274)
Query Neighborhood Hits	495	Target Neighborhood Hits	981	Shared Neighborhood Hits	256
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

KIRR3_MOUSE
θ value	4.30538e-10 (rank : 152)	NC score	0.621499 (rank : 108)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	237
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

PTPRM_MOUSE
θ value	4.30538e-10 (rank : 153)	NC score	0.365313 (rank : 217)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	160
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

FGFR2_MOUSE
θ value	1.25267e-09 (rank : 154)	NC score	0.327175 (rank : 252)
Query Neighborhood Hits	495	Target Neighborhood Hits	1062	Shared Neighborhood Hits	286
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FSTL4_MOUSE
θ value	1.25267e-09 (rank : 155)	NC score	0.647515 (rank : 96)
Query Neighborhood Hits	495	Target Neighborhood Hits	333	Shared Neighborhood Hits	260
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FSTL5_HUMAN
θ value	1.63604e-09 (rank : 156)	NC score	0.655255 (rank : 93)
Query Neighborhood Hits	495	Target Neighborhood Hits	347	Shared Neighborhood Hits	263
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

VGFR2_HUMAN
θ value	2.13673e-09 (rank : 157)	NC score	0.394183 (rank : 191)
Query Neighborhood Hits	495	Target Neighborhood Hits	1103	Shared Neighborhood Hits	328
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

CD22_MOUSE
θ value	2.79066e-09 (rank : 158)	NC score	0.652965 (rank : 95)
Query Neighborhood Hits	495	Target Neighborhood Hits	331	Shared Neighborhood Hits	252
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CEAM1_HUMAN
θ value	2.79066e-09 (rank : 159)	NC score	0.543516 (rank : 147)
Query Neighborhood Hits	495	Target Neighborhood Hits	348	Shared Neighborhood Hits	256
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

FSTL4_HUMAN
θ value	4.76016e-09 (rank : 160)	NC score	0.653453 (rank : 94)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	265
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

TENN_HUMAN
θ value	4.76016e-09 (rank : 161)	NC score	0.337193 (rank : 242)
Query Neighborhood Hits	495	Target Neighborhood Hits	453	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

EPHA4_MOUSE
θ value	6.21693e-09 (rank : 162)	NC score	0.243611 (rank : 338)
Query Neighborhood Hits	495	Target Neighborhood Hits	982	Shared Neighborhood Hits	187
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

NTRK2_HUMAN
θ value	6.21693e-09 (rank : 163)	NC score	0.287443 (rank : 283)
Query Neighborhood Hits	495	Target Neighborhood Hits	1081	Shared Neighborhood Hits	268
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

ROR1_HUMAN
θ value	6.21693e-09 (rank : 164)	NC score	0.279498 (rank : 290)
Query Neighborhood Hits	495	Target Neighborhood Hits	1018	Shared Neighborhood Hits	257
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

TIE1_HUMAN
θ value	8.11959e-09 (rank : 165)	NC score	0.261528 (rank : 315)
Query Neighborhood Hits	495	Target Neighborhood Hits	1241	Shared Neighborhood Hits	219
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

CI094_HUMAN
θ value	1.06045e-08 (rank : 166)	NC score	0.560522 (rank : 139)
Query Neighborhood Hits	495	Target Neighborhood Hits	310	Shared Neighborhood Hits	230
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

EPHA4_HUMAN
θ value	1.06045e-08 (rank : 167)	NC score	0.240770 (rank : 343)
Query Neighborhood Hits	495	Target Neighborhood Hits	975	Shared Neighborhood Hits	184
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHB2_HUMAN
θ value	1.38499e-08 (rank : 168)	NC score	0.225411 (rank : 357)
Query Neighborhood Hits	495	Target Neighborhood Hits	983	Shared Neighborhood Hits	175
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	1.38499e-08 (rank : 169)	NC score	0.225417 (rank : 356)
Query Neighborhood Hits	495	Target Neighborhood Hits	982	Shared Neighborhood Hits	175
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

KIRR2_MOUSE
θ value	1.38499e-08 (rank : 170)	NC score	0.669025 (rank : 90)
Query Neighborhood Hits	495	Target Neighborhood Hits	326	Shared Neighborhood Hits	253
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

NTRK2_MOUSE
θ value	1.38499e-08 (rank : 171)	NC score	0.287318 (rank : 284)
Query Neighborhood Hits	495	Target Neighborhood Hits	1088	Shared Neighborhood Hits	267
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

PTPRT_HUMAN
θ value	1.38499e-08 (rank : 172)	NC score	0.338580 (rank : 238)
Query Neighborhood Hits	495	Target Neighborhood Hits	217	Shared Neighborhood Hits	138
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	1.38499e-08 (rank : 173)	NC score	0.339493 (rank : 237)
Query Neighborhood Hits	495	Target Neighborhood Hits	219	Shared Neighborhood Hits	139
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

FSTL5_MOUSE
θ value	1.80886e-08 (rank : 174)	NC score	0.646989 (rank : 97)
Query Neighborhood Hits	495	Target Neighborhood Hits	355	Shared Neighborhood Hits	258
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

CD166_MOUSE
θ value	2.36244e-08 (rank : 175)	NC score	0.514213 (rank : 152)
Query Neighborhood Hits	495	Target Neighborhood Hits	252	Shared Neighborhood Hits	205
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CD166_HUMAN
θ value	3.08544e-08 (rank : 176)	NC score	0.484307 (rank : 160)
Query Neighborhood Hits	495	Target Neighborhood Hits	247	Shared Neighborhood Hits	197
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

EPHA8_HUMAN
θ value	3.08544e-08 (rank : 177)	NC score	0.245041 (rank : 336)
Query Neighborhood Hits	495	Target Neighborhood Hits	956	Shared Neighborhood Hits	187
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	3.08544e-08 (rank : 178)	NC score	0.248200 (rank : 331)
Query Neighborhood Hits	495	Target Neighborhood Hits	969	Shared Neighborhood Hits	189
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

MAG_HUMAN
θ value	3.08544e-08 (rank : 179)	NC score	0.676804 (rank : 86)
Query Neighborhood Hits	495	Target Neighborhood Hits	278	Shared Neighborhood Hits	254
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

EPHA5_MOUSE
θ value	5.26297e-08 (rank : 180)	NC score	0.210143 (rank : 369)
Query Neighborhood Hits	495	Target Neighborhood Hits	950	Shared Neighborhood Hits	179
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ICAM5_HUMAN
θ value	5.26297e-08 (rank : 181)	NC score	0.615601 (rank : 111)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	242
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

NTRI_MOUSE
θ value	5.26297e-08 (rank : 182)	NC score	0.720542 (rank : 77)
Query Neighborhood Hits	495	Target Neighborhood Hits	342	Shared Neighborhood Hits	295
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

PTPRU_HUMAN
θ value	5.26297e-08 (rank : 183)	NC score	0.320772 (rank : 257)
Query Neighborhood Hits	495	Target Neighborhood Hits	237	Shared Neighborhood Hits	156
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

CD22_HUMAN
θ value	8.97725e-08 (rank : 184)	NC score	0.641216 (rank : 100)
Query Neighborhood Hits	495	Target Neighborhood Hits	365	Shared Neighborhood Hits	264
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

DUET_HUMAN
θ value	8.97725e-08 (rank : 185)	NC score	0.270938 (rank : 305)
Query Neighborhood Hits	495	Target Neighborhood Hits	1220	Shared Neighborhood Hits	280
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

LRC4B_MOUSE
θ value	8.97725e-08 (rank : 186)	NC score	0.274634 (rank : 297)
Query Neighborhood Hits	495	Target Neighborhood Hits	484	Shared Neighborhood Hits	216
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

I12R2_MOUSE
θ value	1.17247e-07 (rank : 187)	NC score	0.420940 (rank : 178)
Query Neighborhood Hits	495	Target Neighborhood Hits	143	Shared Neighborhood Hits	120
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

VCAM1_MOUSE
θ value	1.17247e-07 (rank : 188)	NC score	0.694735 (rank : 81)
Query Neighborhood Hits	495	Target Neighborhood Hits	320	Shared Neighborhood Hits	271
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

LRC4B_HUMAN
θ value	1.53129e-07 (rank : 189)	NC score	0.271766 (rank : 302)
Query Neighborhood Hits	495	Target Neighborhood Hits	479	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

EPHB4_MOUSE
θ value	2.61198e-07 (rank : 190)	NC score	0.235980 (rank : 349)
Query Neighborhood Hits	495	Target Neighborhood Hits	1013	Shared Neighborhood Hits	186
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA3_MOUSE
θ value	3.41135e-07 (rank : 191)	NC score	0.242570 (rank : 340)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	192
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

IBP7_HUMAN
θ value	4.45536e-07 (rank : 192)	NC score	0.504948 (rank : 153)
Query Neighborhood Hits	495	Target Neighborhood Hits	220	Shared Neighborhood Hits	166
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

PTPRK_MOUSE
θ value	4.45536e-07 (rank : 193)	NC score	0.302625 (rank : 270)
Query Neighborhood Hits	495	Target Neighborhood Hits	223	Shared Neighborhood Hits	139
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

EPHB1_HUMAN
θ value	5.81887e-07 (rank : 194)	NC score	0.224793 (rank : 358)
Query Neighborhood Hits	495	Target Neighborhood Hits	988	Shared Neighborhood Hits	179
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

TIE1_MOUSE
θ value	5.81887e-07 (rank : 195)	NC score	0.268776 (rank : 307)
Query Neighborhood Hits	495	Target Neighborhood Hits	1266	Shared Neighborhood Hits	232
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

LRFN5_MOUSE
θ value	7.59969e-07 (rank : 196)	NC score	0.361287 (rank : 222)
Query Neighborhood Hits	495	Target Neighborhood Hits	472	Shared Neighborhood Hits	231
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

SIG10_HUMAN
θ value	7.59969e-07 (rank : 197)	NC score	0.548739 (rank : 146)
Query Neighborhood Hits	495	Target Neighborhood Hits	363	Shared Neighborhood Hits	237
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

JAM3_MOUSE
θ value	9.92553e-07 (rank : 198)	NC score	0.617183 (rank : 109)
Query Neighborhood Hits	495	Target Neighborhood Hits	286	Shared Neighborhood Hits	239
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

PTPRK_HUMAN
θ value	9.92553e-07 (rank : 199)	NC score	0.298676 (rank : 275)
Query Neighborhood Hits	495	Target Neighborhood Hits	228	Shared Neighborhood Hits	142
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

IBP7_MOUSE
θ value	1.29631e-06 (rank : 200)	NC score	0.489091 (rank : 158)
Query Neighborhood Hits	495	Target Neighborhood Hits	230	Shared Neighborhood Hits	163
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IL6RB_MOUSE
θ value	1.29631e-06 (rank : 201)	NC score	0.441945 (rank : 173)
Query Neighborhood Hits	495	Target Neighborhood Hits	168	Shared Neighborhood Hits	135
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

TENA_MOUSE
θ value	1.29631e-06 (rank : 202)	NC score	0.274878 (rank : 296)
Query Neighborhood Hits	495	Target Neighborhood Hits	596	Shared Neighborhood Hits	147
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

TIE2_MOUSE
θ value	1.29631e-06 (rank : 203)	NC score	0.250086 (rank : 328)
Query Neighborhood Hits	495	Target Neighborhood Hits	1204	Shared Neighborhood Hits	200
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

VGFR3_MOUSE
θ value	1.29631e-06 (rank : 204)	NC score	0.336431 (rank : 243)
Query Neighborhood Hits	495	Target Neighborhood Hits	1056	Shared Neighborhood Hits	307
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

BASI_HUMAN
θ value	1.69304e-06 (rank : 205)	NC score	0.558003 (rank : 140)
Query Neighborhood Hits	495	Target Neighborhood Hits	211	Shared Neighborhood Hits	194
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

EPHA3_HUMAN
θ value	1.69304e-06 (rank : 206)	NC score	0.237584 (rank : 346)
Query Neighborhood Hits	495	Target Neighborhood Hits	1005	Shared Neighborhood Hits	194
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHB3_MOUSE
θ value	1.69304e-06 (rank : 207)	NC score	0.245474 (rank : 335)
Query Neighborhood Hits	495	Target Neighborhood Hits	996	Shared Neighborhood Hits	187
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

LRFN5_HUMAN
θ value	1.69304e-06 (rank : 208)	NC score	0.354099 (rank : 230)
Query Neighborhood Hits	495	Target Neighborhood Hits	464	Shared Neighborhood Hits	226
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

LRRC4_HUMAN
θ value	1.69304e-06 (rank : 209)	NC score	0.247309 (rank : 333)
Query Neighborhood Hits	495	Target Neighborhood Hits	444	Shared Neighborhood Hits	198
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

PGFRB_MOUSE
θ value	1.69304e-06 (rank : 210)	NC score	0.268659 (rank : 308)
Query Neighborhood Hits	495	Target Neighborhood Hits	960	Shared Neighborhood Hits	226
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

VCAM1_HUMAN
θ value	1.69304e-06 (rank : 211)	NC score	0.690232 (rank : 83)
Query Neighborhood Hits	495	Target Neighborhood Hits	352	Shared Neighborhood Hits	269
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

NTRI_HUMAN
θ value	2.21117e-06 (rank : 212)	NC score	0.715841 (rank : 78)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	294
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

PTPRB_HUMAN
θ value	2.88788e-06 (rank : 213)	NC score	0.252304 (rank : 324)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	109
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

VGFR3_HUMAN
θ value	3.77169e-06 (rank : 214)	NC score	0.335193 (rank : 244)
Query Neighborhood Hits	495	Target Neighborhood Hits	1037	Shared Neighborhood Hits	296
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

CILP2_HUMAN
θ value	4.92598e-06 (rank : 215)	NC score	0.383221 (rank : 201)
Query Neighborhood Hits	495	Target Neighborhood Hits	307	Shared Neighborhood Hits	188
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

LRFN4_HUMAN
θ value	4.92598e-06 (rank : 216)	NC score	0.395788 (rank : 189)
Query Neighborhood Hits	495	Target Neighborhood Hits	462	Shared Neighborhood Hits	228
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

NGL1_HUMAN
θ value	4.92598e-06 (rank : 217)	NC score	0.271241 (rank : 304)
Query Neighborhood Hits	495	Target Neighborhood Hits	511	Shared Neighborhood Hits	223
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_MOUSE
θ value	4.92598e-06 (rank : 218)	NC score	0.271512 (rank : 303)
Query Neighborhood Hits	495	Target Neighborhood Hits	512	Shared Neighborhood Hits	223
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

EPHB3_HUMAN
θ value	6.43352e-06 (rank : 219)	NC score	0.243449 (rank : 339)
Query Neighborhood Hits	495	Target Neighborhood Hits	996	Shared Neighborhood Hits	186
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

ROS_HUMAN
θ value	6.43352e-06 (rank : 220)	NC score	0.241216 (rank : 341)
Query Neighborhood Hits	495	Target Neighborhood Hits	907	Shared Neighborhood Hits	189
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

LIFR_HUMAN
θ value	8.40245e-06 (rank : 221)	NC score	0.422135 (rank : 176)
Query Neighborhood Hits	495	Target Neighborhood Hits	130	Shared Neighborhood Hits	99
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

TIE2_HUMAN
θ value	8.40245e-06 (rank : 222)	NC score	0.246898 (rank : 334)
Query Neighborhood Hits	495	Target Neighborhood Hits	1192	Shared Neighborhood Hits	200
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

JAM2_HUMAN
θ value	1.09739e-05 (rank : 223)	NC score	0.593867 (rank : 125)
Query Neighborhood Hits	495	Target Neighborhood Hits	304	Shared Neighborhood Hits	267
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

JAM3_HUMAN
θ value	1.09739e-05 (rank : 224)	NC score	0.616050 (rank : 110)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	237
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

SIG11_HUMAN
θ value	1.09739e-05 (rank : 225)	NC score	0.555586 (rank : 144)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	244
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

CSF3R_HUMAN
θ value	1.43324e-05 (rank : 226)	NC score	0.363625 (rank : 219)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	110
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

JAM1_HUMAN
θ value	1.43324e-05 (rank : 227)	NC score	0.633619 (rank : 102)
Query Neighborhood Hits	495	Target Neighborhood Hits	294	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

CSF3R_MOUSE
θ value	1.87187e-05 (rank : 228)	NC score	0.301674 (rank : 272)
Query Neighborhood Hits	495	Target Neighborhood Hits	104	Shared Neighborhood Hits	89
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

JAM1_MOUSE
θ value	1.87187e-05 (rank : 229)	NC score	0.611796 (rank : 115)
Query Neighborhood Hits	495	Target Neighborhood Hits	287	Shared Neighborhood Hits	240
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

LRRC4_MOUSE
θ value	1.87187e-05 (rank : 230)	NC score	0.217175 (rank : 364)
Query Neighborhood Hits	495	Target Neighborhood Hits	412	Shared Neighborhood Hits	171
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

ROR2_HUMAN
θ value	1.87187e-05 (rank : 231)	NC score	0.287706 (rank : 282)
Query Neighborhood Hits	495	Target Neighborhood Hits	1014	Shared Neighborhood Hits	260
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	1.87187e-05 (rank : 232)	NC score	0.297573 (rank : 276)
Query Neighborhood Hits	495	Target Neighborhood Hits	1000	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

EPHA6_MOUSE
θ value	2.44474e-05 (rank : 233)	NC score	0.207422 (rank : 371)
Query Neighborhood Hits	495	Target Neighborhood Hits	946	Shared Neighborhood Hits	156
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

LIFR_MOUSE
θ value	2.44474e-05 (rank : 234)	NC score	0.411600 (rank : 180)
Query Neighborhood Hits	495	Target Neighborhood Hits	127	Shared Neighborhood Hits	99
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

MYBPH_MOUSE
θ value	2.44474e-05 (rank : 235)	NC score	0.599081 (rank : 121)
Query Neighborhood Hits	495	Target Neighborhood Hits	290	Shared Neighborhood Hits	237
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

RIMB2_MOUSE
θ value	2.44474e-05 (rank : 236)	NC score	0.188449 (rank : 387)
Query Neighborhood Hits	495	Target Neighborhood Hits	246	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

TMIGD_HUMAN
θ value	2.44474e-05 (rank : 237)	NC score	0.642356 (rank : 99)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	220
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

CD276_HUMAN
θ value	3.19293e-05 (rank : 238)	NC score	0.373504 (rank : 210)
Query Neighborhood Hits	495	Target Neighborhood Hits	261	Shared Neighborhood Hits	168
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

EPHA6_HUMAN
θ value	3.19293e-05 (rank : 239)	NC score	0.216314 (rank : 366)
Query Neighborhood Hits	495	Target Neighborhood Hits	959	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

LU_HUMAN
θ value	3.19293e-05 (rank : 240)	NC score	0.658445 (rank : 92)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	249
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

LRFN4_MOUSE
θ value	4.1701e-05 (rank : 241)	NC score	0.389270 (rank : 193)
Query Neighborhood Hits	495	Target Neighborhood Hits	442	Shared Neighborhood Hits	220
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRRN3_MOUSE
θ value	4.1701e-05 (rank : 242)	NC score	0.315158 (rank : 261)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	224
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PSG11_HUMAN
θ value	4.1701e-05 (rank : 243)	NC score	0.396077 (rank : 188)
Query Neighborhood Hits	495	Target Neighborhood Hits	223	Shared Neighborhood Hits	204
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

EPHB4_HUMAN
θ value	5.44631e-05 (rank : 244)	NC score	0.229558 (rank : 353)
Query Neighborhood Hits	495	Target Neighborhood Hits	1056	Shared Neighborhood Hits	191
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

IL1R2_HUMAN
θ value	5.44631e-05 (rank : 245)	NC score	0.386137 (rank : 197)
Query Neighborhood Hits	495	Target Neighborhood Hits	153	Shared Neighborhood Hits	133
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

LRC24_HUMAN
θ value	5.44631e-05 (rank : 246)	NC score	0.282776 (rank : 288)
Query Neighborhood Hits	495	Target Neighborhood Hits	404	Shared Neighborhood Hits	196
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

LRRN3_HUMAN
θ value	5.44631e-05 (rank : 247)	NC score	0.328742 (rank : 250)
Query Neighborhood Hits	495	Target Neighborhood Hits	461	Shared Neighborhood Hits	228
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PSG3_HUMAN
θ value	5.44631e-05 (rank : 248)	NC score	0.412034 (rank : 179)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	214
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

TMIGD_MOUSE
θ value	5.44631e-05 (rank : 249)	NC score	0.615570 (rank : 112)
Query Neighborhood Hits	495	Target Neighborhood Hits	234	Shared Neighborhood Hits	221
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

KAZD1_HUMAN
θ value	7.1131e-05 (rank : 250)	NC score	0.518942 (rank : 151)
Query Neighborhood Hits	495	Target Neighborhood Hits	248	Shared Neighborhood Hits	168
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

LRFN3_MOUSE
θ value	7.1131e-05 (rank : 251)	NC score	0.377944 (rank : 208)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	230
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

EPHB6_HUMAN
θ value	9.29e-05 (rank : 252)	NC score	0.259663 (rank : 317)
Query Neighborhood Hits	495	Target Neighborhood Hits	912	Shared Neighborhood Hits	181
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

HCFC2_HUMAN
θ value	9.29e-05 (rank : 253)	NC score	0.226283 (rank : 355)
Query Neighborhood Hits	495	Target Neighborhood Hits	154	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

CT075_HUMAN
θ value	0.000158464 (rank : 254)	NC score	0.220641 (rank : 360)
Query Neighborhood Hits	495	Target Neighborhood Hits	387	Shared Neighborhood Hits	121
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

EPHA2_HUMAN
θ value	0.000158464 (rank : 255)	NC score	0.218617 (rank : 361)
Query Neighborhood Hits	495	Target Neighborhood Hits	1021	Shared Neighborhood Hits	177
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

KAZD1_MOUSE
θ value	0.000158464 (rank : 256)	NC score	0.557193 (rank : 141)
Query Neighborhood Hits	495	Target Neighborhood Hits	281	Shared Neighborhood Hits	203
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

PSG8_HUMAN
θ value	0.000158464 (rank : 257)	NC score	0.406892 (rank : 182)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PTPRV_MOUSE
θ value	0.000158464 (rank : 258)	NC score	0.218068 (rank : 362)
Query Neighborhood Hits	495	Target Neighborhood Hits	179	Shared Neighborhood Hits	84
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

VSIG2_HUMAN
θ value	0.000158464 (rank : 259)	NC score	0.570409 (rank : 133)
Query Neighborhood Hits	495	Target Neighborhood Hits	321	Shared Neighborhood Hits	244
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

CXAR_MOUSE
θ value	0.00020696 (rank : 260)	NC score	0.365991 (rank : 216)
Query Neighborhood Hits	495	Target Neighborhood Hits	250	Shared Neighborhood Hits	172
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

INSRR_HUMAN
θ value	0.00020696 (rank : 261)	NC score	0.198688 (rank : 377)
Query Neighborhood Hits	495	Target Neighborhood Hits	950	Shared Neighborhood Hits	142
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

LRFN2_MOUSE
θ value	0.00020696 (rank : 262)	NC score	0.382179 (rank : 204)
Query Neighborhood Hits	495	Target Neighborhood Hits	450	Shared Neighborhood Hits	229
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

MUC18_HUMAN
θ value	0.00020696 (rank : 263)	NC score	0.629330 (rank : 105)
Query Neighborhood Hits	495	Target Neighborhood Hits	275	Shared Neighborhood Hits	230
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

PGFRA_HUMAN
θ value	0.00020696 (rank : 264)	NC score	0.274147 (rank : 298)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	238
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

VSIG2_MOUSE
θ value	0.00020696 (rank : 265)	NC score	0.556958 (rank : 143)
Query Neighborhood Hits	495	Target Neighborhood Hits	316	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

EPHB6_MOUSE
θ value	0.000270298 (rank : 266)	NC score	0.252755 (rank : 322)
Query Neighborhood Hits	495	Target Neighborhood Hits	906	Shared Neighborhood Hits	172
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

FCRL5_HUMAN
θ value	0.000270298 (rank : 267)	NC score	0.568645 (rank : 135)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	222
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

LRC21_MOUSE
θ value	0.000270298 (rank : 268)	NC score	0.369084 (rank : 215)
Query Neighborhood Hits	495	Target Neighborhood Hits	462	Shared Neighborhood Hits	245
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRFN2_HUMAN
θ value	0.000270298 (rank : 269)	NC score	0.381889 (rank : 205)
Query Neighborhood Hits	495	Target Neighborhood Hits	450	Shared Neighborhood Hits	223
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

NPTN_MOUSE
θ value	0.000270298 (rank : 270)	NC score	0.593282 (rank : 126)
Query Neighborhood Hits	495	Target Neighborhood Hits	216	Shared Neighborhood Hits	200
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

PSG1_HUMAN
θ value	0.000270298 (rank : 271)	NC score	0.388011 (rank : 195)
Query Neighborhood Hits	495	Target Neighborhood Hits	232	Shared Neighborhood Hits	206
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PSG9_HUMAN
θ value	0.000270298 (rank : 272)	NC score	0.369143 (rank : 214)
Query Neighborhood Hits	495	Target Neighborhood Hits	221	Shared Neighborhood Hits	196
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

SIGL5_MOUSE
θ value	0.000270298 (rank : 273)	NC score	0.454289 (rank : 169)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	231
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

BASI_MOUSE
θ value	0.00035302 (rank : 274)	NC score	0.542946 (rank : 148)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	208
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

PGFRA_MOUSE
θ value	0.00035302 (rank : 275)	NC score	0.272636 (rank : 300)
Query Neighborhood Hits	495	Target Neighborhood Hits	975	Shared Neighborhood Hits	238
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PSG2_HUMAN
θ value	0.00035302 (rank : 276)	NC score	0.383078 (rank : 203)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	203
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

FCRLA_HUMAN
θ value	0.000461057 (rank : 277)	NC score	0.153524 (rank : 413)
Query Neighborhood Hits	495	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

CEA20_HUMAN
θ value	0.000602161 (rank : 278)	NC score	0.561655 (rank : 137)
Query Neighborhood Hits	495	Target Neighborhood Hits	251	Shared Neighborhood Hits	206
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

HCFC2_MOUSE
θ value	0.000602161 (rank : 279)	NC score	0.334093 (rank : 247)
Query Neighborhood Hits	495	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

IL27B_HUMAN
θ value	0.000602161 (rank : 280)	NC score	0.212689 (rank : 367)
Query Neighborhood Hits	495	Target Neighborhood Hits	80	Shared Neighborhood Hits	66
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

MUC18_MOUSE
θ value	0.000602161 (rank : 281)	NC score	0.613371 (rank : 113)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	230
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

TRIO_HUMAN
θ value	0.000602161 (rank : 282)	NC score	0.183840 (rank : 392)
Query Neighborhood Hits	495	Target Neighborhood Hits	1580	Shared Neighborhood Hits	283
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

CT075_MOUSE
θ value	0.000786445 (rank : 283)	NC score	0.181889 (rank : 394)
Query Neighborhood Hits	495	Target Neighborhood Hits	358	Shared Neighborhood Hits	101
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

MYBPH_HUMAN
θ value	0.000786445 (rank : 284)	NC score	0.587832 (rank : 127)
Query Neighborhood Hits	495	Target Neighborhood Hits	256	Shared Neighborhood Hits	231
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

CEAM6_HUMAN
θ value	0.00102713 (rank : 285)	NC score	0.476165 (rank : 162)
Query Neighborhood Hits	495	Target Neighborhood Hits	308	Shared Neighborhood Hits	254
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

CXAR_HUMAN
θ value	0.00102713 (rank : 286)	NC score	0.380664 (rank : 206)
Query Neighborhood Hits	495	Target Neighborhood Hits	245	Shared Neighborhood Hits	173
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

FCRLA_MOUSE
θ value	0.00102713 (rank : 287)	NC score	0.145897 (rank : 419)
Query Neighborhood Hits	495	Target Neighborhood Hits	110	Shared Neighborhood Hits	65
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

GPA33_HUMAN
θ value	0.00102713 (rank : 288)	NC score	0.467479 (rank : 165)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	200
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

LRFN3_HUMAN
θ value	0.00102713 (rank : 289)	NC score	0.359023 (rank : 225)
Query Neighborhood Hits	495	Target Neighborhood Hits	444	Shared Neighborhood Hits	216
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

PSG6_HUMAN
θ value	0.00102713 (rank : 290)	NC score	0.386975 (rank : 196)
Query Neighborhood Hits	495	Target Neighborhood Hits	231	Shared Neighborhood Hits	200
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

CRLF1_MOUSE
θ value	0.00134147 (rank : 291)	NC score	0.216423 (rank : 365)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

FCRL2_HUMAN
θ value	0.00134147 (rank : 292)	NC score	0.541780 (rank : 149)
Query Neighborhood Hits	495	Target Neighborhood Hits	251	Shared Neighborhood Hits	205
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

IGS4B_MOUSE
θ value	0.00134147 (rank : 293)	NC score	0.574296 (rank : 132)
Query Neighborhood Hits	495	Target Neighborhood Hits	328	Shared Neighborhood Hits	257
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

INSR_MOUSE
θ value	0.00134147 (rank : 294)	NC score	0.190775 (rank : 385)
Query Neighborhood Hits	495	Target Neighborhood Hits	968	Shared Neighborhood Hits	143
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KIT_MOUSE
θ value	0.00134147 (rank : 295)	NC score	0.264923 (rank : 310)
Query Neighborhood Hits	495	Target Neighborhood Hits	949	Shared Neighborhood Hits	221
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

PSG7_HUMAN
θ value	0.00134147 (rank : 296)	NC score	0.395440 (rank : 190)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	209
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

PVRL1_MOUSE
θ value	0.00134147 (rank : 297)	NC score	0.295361 (rank : 278)
Query Neighborhood Hits	495	Target Neighborhood Hits	201	Shared Neighborhood Hits	157
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

PVRL2_HUMAN
θ value	0.00134147 (rank : 298)	NC score	0.236876 (rank : 348)
Query Neighborhood Hits	495	Target Neighborhood Hits	185	Shared Neighborhood Hits	131
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

RIMB2_HUMAN
θ value	0.00134147 (rank : 299)	NC score	0.194120 (rank : 381)
Query Neighborhood Hits	495	Target Neighborhood Hits	263	Shared Neighborhood Hits	64
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

UNC5B_HUMAN
θ value	0.00134147 (rank : 300)	NC score	0.267567 (rank : 309)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	131
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5C_HUMAN
θ value	0.00134147 (rank : 301)	NC score	0.277403 (rank : 293)
Query Neighborhood Hits	495	Target Neighborhood Hits	226	Shared Neighborhood Hits	128
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

IGS21_HUMAN
θ value	0.00175202 (rank : 302)	NC score	0.269057 (rank : 306)
Query Neighborhood Hits	495	Target Neighborhood Hits	123	Shared Neighborhood Hits	105
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGS4B_HUMAN
θ value	0.00175202 (rank : 303)	NC score	0.564146 (rank : 136)
Query Neighborhood Hits	495	Target Neighborhood Hits	305	Shared Neighborhood Hits	245
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

INSRR_MOUSE
θ value	0.00175202 (rank : 304)	NC score	0.198677 (rank : 378)
Query Neighborhood Hits	495	Target Neighborhood Hits	961	Shared Neighborhood Hits	142
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	0.00175202 (rank : 305)	NC score	0.186188 (rank : 390)
Query Neighborhood Hits	495	Target Neighborhood Hits	963	Shared Neighborhood Hits	139
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

NPTN_HUMAN
θ value	0.00175202 (rank : 306)	NC score	0.600509 (rank : 119)
Query Neighborhood Hits	495	Target Neighborhood Hits	212	Shared Neighborhood Hits	200
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

PSG10_HUMAN
θ value	0.00175202 (rank : 307)	NC score	0.383229 (rank : 200)
Query Neighborhood Hits	495	Target Neighborhood Hits	227	Shared Neighborhood Hits	199
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

RAGE_HUMAN
θ value	0.00175202 (rank : 308)	NC score	0.632806 (rank : 103)
Query Neighborhood Hits	495	Target Neighborhood Hits	269	Shared Neighborhood Hits	244
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

KALM_HUMAN
θ value	0.00228821 (rank : 309)	NC score	0.331678 (rank : 249)
Query Neighborhood Hits	495	Target Neighborhood Hits	114	Shared Neighborhood Hits	79
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

KIT_HUMAN
θ value	0.00228821 (rank : 310)	NC score	0.252087 (rank : 325)
Query Neighborhood Hits	495	Target Neighborhood Hits	953	Shared Neighborhood Hits	215
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

LRC24_MOUSE
θ value	0.00228821 (rank : 311)	NC score	0.259585 (rank : 318)
Query Neighborhood Hits	495	Target Neighborhood Hits	387	Shared Neighborhood Hits	193
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

LRRN5_HUMAN
θ value	0.00228821 (rank : 312)	NC score	0.309855 (rank : 265)
Query Neighborhood Hits	495	Target Neighborhood Hits	493	Shared Neighborhood Hits	244
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

SIGL8_HUMAN
θ value	0.00228821 (rank : 313)	NC score	0.360801 (rank : 223)
Query Neighborhood Hits	495	Target Neighborhood Hits	252	Shared Neighborhood Hits	219
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

CRLF1_HUMAN
θ value	0.00298849 (rank : 314)	NC score	0.223060 (rank : 359)
Query Neighborhood Hits	495	Target Neighborhood Hits	122	Shared Neighborhood Hits	92
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

JAM2_MOUSE
θ value	0.00298849 (rank : 315)	NC score	0.568891 (rank : 134)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	254
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

NRG1_HUMAN
θ value	0.00298849 (rank : 316)	NC score	0.364443 (rank : 218)
Query Neighborhood Hits	495	Target Neighborhood Hits	285	Shared Neighborhood Hits	169
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

UNC5B_MOUSE
θ value	0.00298849 (rank : 317)	NC score	0.263512 (rank : 312)
Query Neighborhood Hits	495	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

EPHA2_MOUSE
θ value	0.00390308 (rank : 318)	NC score	0.211549 (rank : 368)
Query Neighborhood Hits	495	Target Neighborhood Hits	1020	Shared Neighborhood Hits	169
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

LRRN1_HUMAN
θ value	0.00390308 (rank : 319)	NC score	0.334109 (rank : 246)
Query Neighborhood Hits	495	Target Neighborhood Hits	518	Shared Neighborhood Hits	259
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

NTRK3_HUMAN
θ value	0.00390308 (rank : 320)	NC score	0.286538 (rank : 285)
Query Neighborhood Hits	495	Target Neighborhood Hits	1115	Shared Neighborhood Hits	263
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PTPRZ_HUMAN
θ value	0.00390308 (rank : 321)	NC score	0.124324 (rank : 468)
Query Neighborhood Hits	495	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

UNC5C_MOUSE
θ value	0.00390308 (rank : 322)	NC score	0.277908 (rank : 292)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	131
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

LRRN1_MOUSE
θ value	0.00509761 (rank : 323)	NC score	0.322585 (rank : 254)
Query Neighborhood Hits	495	Target Neighborhood Hits	508	Shared Neighborhood Hits	255
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

SIGL5_HUMAN
θ value	0.00509761 (rank : 324)	NC score	0.369184 (rank : 213)
Query Neighborhood Hits	495	Target Neighborhood Hits	246	Shared Neighborhood Hits	195
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

UNC5A_HUMAN
θ value	0.00509761 (rank : 325)	NC score	0.284090 (rank : 287)
Query Neighborhood Hits	495	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5A_MOUSE
θ value	0.00509761 (rank : 326)	NC score	0.252344 (rank : 323)
Query Neighborhood Hits	495	Target Neighborhood Hits	203	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

I11RB_MOUSE
θ value	0.00665767 (rank : 327)	NC score	0.172975 (rank : 402)
Query Neighborhood Hits	495	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

SIG12_HUMAN
θ value	0.00665767 (rank : 328)	NC score	0.339628 (rank : 236)
Query Neighborhood Hits	495	Target Neighborhood Hits	245	Shared Neighborhood Hits	220
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

I11RA_MOUSE
θ value	0.00869519 (rank : 329)	NC score	0.160864 (rank : 412)
Query Neighborhood Hits	495	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

IRPL2_HUMAN
θ value	0.00869519 (rank : 330)	NC score	0.317845 (rank : 258)
Query Neighborhood Hits	495	Target Neighborhood Hits	194	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

IRPL2_MOUSE
θ value	0.00869519 (rank : 331)	NC score	0.314486 (rank : 262)
Query Neighborhood Hits	495	Target Neighborhood Hits	195	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

IGF1R_HUMAN
θ value	0.0113563 (rank : 332)	NC score	0.191636 (rank : 384)
Query Neighborhood Hits	495	Target Neighborhood Hits	977	Shared Neighborhood Hits	144
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IRPL1_MOUSE
θ value	0.0113563 (rank : 333)	NC score	0.309596 (rank : 266)
Query Neighborhood Hits	495	Target Neighborhood Hits	186	Shared Neighborhood Hits	154
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

LRC21_HUMAN
θ value	0.0113563 (rank : 334)	NC score	0.361340 (rank : 221)
Query Neighborhood Hits	495	Target Neighborhood Hits	456	Shared Neighborhood Hits	242
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

PGFRB_HUMAN
θ value	0.0113563 (rank : 335)	NC score	0.257126 (rank : 319)
Query Neighborhood Hits	495	Target Neighborhood Hits	962	Shared Neighborhood Hits	232
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RIMB1_HUMAN
θ value	0.0113563 (rank : 336)	NC score	0.046605 (rank : 1125)
Query Neighborhood Hits	495	Target Neighborhood Hits	1479	Shared Neighborhood Hits	47
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SET1A_HUMAN
θ value	0.0113563 (rank : 337)	NC score	0.029513 (rank : 1139)
Query Neighborhood Hits	495	Target Neighborhood Hits	690	Shared Neighborhood Hits	21
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

CEAM8_HUMAN
θ value	0.0148317 (rank : 338)	NC score	0.420947 (rank : 177)
Query Neighborhood Hits	495	Target Neighborhood Hits	264	Shared Neighborhood Hits	225
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

GPA33_MOUSE
θ value	0.0148317 (rank : 339)	NC score	0.482323 (rank : 161)
Query Neighborhood Hits	495	Target Neighborhood Hits	294	Shared Neighborhood Hits	204
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

HCFC1_MOUSE
θ value	0.0148317 (rank : 340)	NC score	0.144517 (rank : 424)
Query Neighborhood Hits	495	Target Neighborhood Hits	348	Shared Neighborhood Hits	69
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

IL1R2_MOUSE
θ value	0.0148317 (rank : 341)	NC score	0.316441 (rank : 260)
Query Neighborhood Hits	495	Target Neighborhood Hits	125	Shared Neighborhood Hits	102
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

VSIG4_HUMAN
θ value	0.0148317 (rank : 342)	NC score	0.487564 (rank : 159)
Query Neighborhood Hits	495	Target Neighborhood Hits	236	Shared Neighborhood Hits	197
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

UBP2L_MOUSE
θ value	0.0193708 (rank : 343)	NC score	0.041696 (rank : 1128)
Query Neighborhood Hits	495	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

ILRL2_MOUSE
θ value	0.0252991 (rank : 344)	NC score	0.259928 (rank : 316)
Query Neighborhood Hits	495	Target Neighborhood Hits	158	Shared Neighborhood Hits	141
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

IRPL1_HUMAN
θ value	0.0252991 (rank : 345)	NC score	0.301907 (rank : 271)
Query Neighborhood Hits	495	Target Neighborhood Hits	196	Shared Neighborhood Hits	163
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

MALT1_HUMAN
θ value	0.0252991 (rank : 346)	NC score	0.643825 (rank : 98)
Query Neighborhood Hits	495	Target Neighborhood Hits	236	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

MOX2R_MOUSE
θ value	0.0252991 (rank : 347)	NC score	0.284449 (rank : 286)
Query Neighborhood Hits	495	Target Neighborhood Hits	110	Shared Neighborhood Hits	101
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

PECA1_HUMAN
θ value	0.0252991 (rank : 348)	NC score	0.317802 (rank : 259)
Query Neighborhood Hits	495	Target Neighborhood Hits	178	Shared Neighborhood Hits	148
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

PSG5_HUMAN
θ value	0.0252991 (rank : 349)	NC score	0.359918 (rank : 224)
Query Neighborhood Hits	495	Target Neighborhood Hits	231	Shared Neighborhood Hits	203
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

UBP2L_HUMAN
θ value	0.0252991 (rank : 350)	NC score	0.041095 (rank : 1129)
Query Neighborhood Hits	495	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

UNC5D_HUMAN
θ value	0.0252991 (rank : 351)	NC score	0.332113 (rank : 248)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	175
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	0.0252991 (rank : 352)	NC score	0.337568 (rank : 239)
Query Neighborhood Hits	495	Target Neighborhood Hits	268	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

CD45_HUMAN
θ value	0.0330416 (rank : 353)	NC score	0.146241 (rank : 418)
Query Neighborhood Hits	495	Target Neighborhood Hits	243	Shared Neighborhood Hits	63
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CEAM7_HUMAN
θ value	0.0330416 (rank : 354)	NC score	0.278187 (rank : 291)
Query Neighborhood Hits	495	Target Neighborhood Hits	170	Shared Neighborhood Hits	139
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

IGF1R_MOUSE
θ value	0.0431538 (rank : 355)	NC score	0.189938 (rank : 386)
Query Neighborhood Hits	495	Target Neighborhood Hits	973	Shared Neighborhood Hits	144
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGS21_MOUSE
θ value	0.0431538 (rank : 356)	NC score	0.263845 (rank : 311)
Query Neighborhood Hits	495	Target Neighborhood Hits	118	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

NRG2_MOUSE
θ value	0.0431538 (rank : 357)	NC score	0.495979 (rank : 156)
Query Neighborhood Hits	495	Target Neighborhood Hits	392	Shared Neighborhood Hits	239
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

PRLR_HUMAN
θ value	0.0431538 (rank : 358)	NC score	0.099772 (rank : 549)
Query Neighborhood Hits	495	Target Neighborhood Hits	95	Shared Neighborhood Hits	51
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PSG4_HUMAN
θ value	0.0431538 (rank : 359)	NC score	0.405273 (rank : 184)
Query Neighborhood Hits	495	Target Neighborhood Hits	243	Shared Neighborhood Hits	211
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

RAGE_MOUSE
θ value	0.0431538 (rank : 360)	NC score	0.600266 (rank : 120)
Query Neighborhood Hits	495	Target Neighborhood Hits	295	Shared Neighborhood Hits	226
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RIMB1_MOUSE
θ value	0.0431538 (rank : 361)	NC score	0.029705 (rank : 1138)
Query Neighborhood Hits	495	Target Neighborhood Hits	1376	Shared Neighborhood Hits	32
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SIG12_MOUSE
θ value	0.0431538 (rank : 362)	NC score	0.238813 (rank : 345)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	167
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

EPHAA_HUMAN
θ value	0.0563607 (rank : 363)	NC score	0.207188 (rank : 373)
Query Neighborhood Hits	495	Target Neighborhood Hits	960	Shared Neighborhood Hits	157
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

MFA3L_HUMAN
θ value	0.0563607 (rank : 364)	NC score	0.521764 (rank : 150)
Query Neighborhood Hits	495	Target Neighborhood Hits	230	Shared Neighborhood Hits	210
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

PTPRO_HUMAN
θ value	0.0563607 (rank : 365)	NC score	0.176128 (rank : 399)
Query Neighborhood Hits	495	Target Neighborhood Hits	139	Shared Neighborhood Hits	63
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

SHPS1_HUMAN
θ value	0.0563607 (rank : 366)	NC score	0.176059 (rank : 400)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	121
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

HCFC1_HUMAN
θ value	0.0736092 (rank : 367)	NC score	0.117723 (rank : 486)
Query Neighborhood Hits	495	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

I12R1_MOUSE
θ value	0.0736092 (rank : 368)	NC score	0.165527 (rank : 410)
Query Neighborhood Hits	495	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

NRG2_HUMAN
θ value	0.0736092 (rank : 369)	NC score	0.500858 (rank : 154)
Query Neighborhood Hits	495	Target Neighborhood Hits	419	Shared Neighborhood Hits	239
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

TARSH_HUMAN
θ value	0.0736092 (rank : 370)	NC score	0.237288 (rank : 347)
Query Neighborhood Hits	495	Target Neighborhood Hits	768	Shared Neighborhood Hits	120
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ANKF1_HUMAN
θ value	0.0961366 (rank : 371)	NC score	0.180112 (rank : 397)
Query Neighborhood Hits	495	Target Neighborhood Hits	126	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

BT1A1_HUMAN
θ value	0.125558 (rank : 372)	NC score	0.088779 (rank : 594)
Query Neighborhood Hits	495	Target Neighborhood Hits	322	Shared Neighborhood Hits	120
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

CILP1_HUMAN
θ value	0.125558 (rank : 373)	NC score	0.304073 (rank : 268)
Query Neighborhood Hits	495	Target Neighborhood Hits	266	Shared Neighborhood Hits	169
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

SIRB1_HUMAN
θ value	0.125558 (rank : 374)	NC score	0.162159 (rank : 411)
Query Neighborhood Hits	495	Target Neighborhood Hits	422	Shared Neighborhood Hits	108
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

AMGO2_HUMAN
θ value	0.163984 (rank : 375)	NC score	0.143858 (rank : 425)
Query Neighborhood Hits	495	Target Neighborhood Hits	357	Shared Neighborhood Hits	135
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

CILP1_MOUSE
θ value	0.163984 (rank : 376)	NC score	0.321869 (rank : 255)
Query Neighborhood Hits	495	Target Neighborhood Hits	282	Shared Neighborhood Hits	188
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

FCGR1_MOUSE
θ value	0.163984 (rank : 377)	NC score	0.179515 (rank : 398)
Query Neighborhood Hits	495	Target Neighborhood Hits	123	Shared Neighborhood Hits	92
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

FILA_HUMAN
θ value	0.163984 (rank : 378)	NC score	0.004211 (rank : 1168)
Query Neighborhood Hits	495	Target Neighborhood Hits	685	Shared Neighborhood Hits	11
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

LSR_MOUSE
θ value	0.163984 (rank : 379)	NC score	0.032627 (rank : 1135)
Query Neighborhood Hits	495	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q99KG5, Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816	Gene names	Lsr, Lisch7
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor precursor (Liver-specific bHLH-Zip transcription factor) (Lipolysis-stimulated receptor) (Liver- specific gene on mouse chromosome 7 protein).

ARI4A_HUMAN
θ value	0.21417 (rank : 380)	NC score	0.017345 (rank : 1148)
Query Neighborhood Hits	495	Target Neighborhood Hits	434	Shared Neighborhood Hits	6
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

ESAM_HUMAN
θ value	0.21417 (rank : 381)	NC score	0.401701 (rank : 187)
Query Neighborhood Hits	495	Target Neighborhood Hits	251	Shared Neighborhood Hits	188
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

FANK1_MOUSE
θ value	0.21417 (rank : 382)	NC score	0.037943 (rank : 1130)
Query Neighborhood Hits	495	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

I11RA_HUMAN
θ value	0.21417 (rank : 383)	NC score	0.152283 (rank : 414)
Query Neighborhood Hits	495	Target Neighborhood Hits	138	Shared Neighborhood Hits	75
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

PTPRJ_MOUSE
θ value	0.21417 (rank : 384)	NC score	0.202520 (rank : 375)
Query Neighborhood Hits	495	Target Neighborhood Hits	188	Shared Neighborhood Hits	96
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PVRL3_MOUSE
θ value	0.21417 (rank : 385)	NC score	0.324788 (rank : 253)
Query Neighborhood Hits	495	Target Neighborhood Hits	212	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

TPSNR_MOUSE
θ value	0.21417 (rank : 386)	NC score	0.134805 (rank : 441)
Query Neighborhood Hits	495	Target Neighborhood Hits	336	Shared Neighborhood Hits	100
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

EPHA1_HUMAN
θ value	0.279714 (rank : 387)	NC score	0.180851 (rank : 395)
Query Neighborhood Hits	495	Target Neighborhood Hits	997	Shared Neighborhood Hits	140
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

FLT3_MOUSE
θ value	0.279714 (rank : 388)	NC score	0.192611 (rank : 383)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	139
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

SIGL7_HUMAN
θ value	0.279714 (rank : 389)	NC score	0.250607 (rank : 327)
Query Neighborhood Hits	495	Target Neighborhood Hits	180	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

CD4_HUMAN
θ value	0.365318 (rank : 390)	NC score	0.142703 (rank : 427)
Query Neighborhood Hits	495	Target Neighborhood Hits	122	Shared Neighborhood Hits	60
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

PDL2_MOUSE
θ value	0.365318 (rank : 391)	NC score	0.232277 (rank : 352)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	96
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PGFRL_MOUSE
θ value	0.365318 (rank : 392)	NC score	0.234518 (rank : 350)
Query Neighborhood Hits	495	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PRLR_MOUSE
θ value	0.365318 (rank : 393)	NC score	0.098077 (rank : 552)
Query Neighborhood Hits	495	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PVRL3_HUMAN
θ value	0.365318 (rank : 394)	NC score	0.310842 (rank : 264)
Query Neighborhood Hits	495	Target Neighborhood Hits	204	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

VASN_MOUSE
θ value	0.365318 (rank : 395)	NC score	0.081169 (rank : 639)
Query Neighborhood Hits	495	Target Neighborhood Hits	426	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

CSF1R_MOUSE
θ value	0.47712 (rank : 396)	NC score	0.301669 (rank : 273)
Query Neighborhood Hits	495	Target Neighborhood Hits	983	Shared Neighborhood Hits	248
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ILRL1_HUMAN
θ value	0.47712 (rank : 397)	NC score	0.240843 (rank : 342)
Query Neighborhood Hits	495	Target Neighborhood Hits	167	Shared Neighborhood Hits	127
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

ILRL2_HUMAN
θ value	0.47712 (rank : 398)	NC score	0.169767 (rank : 406)
Query Neighborhood Hits	495	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

SHPS1_MOUSE
θ value	0.47712 (rank : 399)	NC score	0.114922 (rank : 494)
Query Neighborhood Hits	495	Target Neighborhood Hits	439	Shared Neighborhood Hits	100
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

VASN_HUMAN
θ value	0.47712 (rank : 400)	NC score	0.079196 (rank : 652)
Query Neighborhood Hits	495	Target Neighborhood Hits	449	Shared Neighborhood Hits	64
SwissProt Accessions	Q6EMK4, Q6UXL4, Q6UXL5, Q96CX1	Gene names	VASN, SLITL2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

BTNL2_HUMAN
θ value	0.62314 (rank : 401)	NC score	0.136848 (rank : 439)
Query Neighborhood Hits	495	Target Neighborhood Hits	164	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

CD80_HUMAN
θ value	0.62314 (rank : 402)	NC score	0.196694 (rank : 380)
Query Neighborhood Hits	495	Target Neighborhood Hits	129	Shared Neighborhood Hits	103
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

PVRL1_HUMAN
θ value	0.62314 (rank : 403)	NC score	0.303063 (rank : 269)
Query Neighborhood Hits	495	Target Neighborhood Hits	219	Shared Neighborhood Hits	166
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

PVR_HUMAN
θ value	0.62314 (rank : 404)	NC score	0.262611 (rank : 314)
Query Neighborhood Hits	495	Target Neighborhood Hits	195	Shared Neighborhood Hits	133
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

AMGO2_MOUSE
θ value	0.813845 (rank : 405)	NC score	0.121076 (rank : 477)
Query Neighborhood Hits	495	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

BTNL3_HUMAN
θ value	0.813845 (rank : 406)	NC score	0.022035 (rank : 1142)
Query Neighborhood Hits	495	Target Neighborhood Hits	143	Shared Neighborhood Hits	44
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

CD226_HUMAN
θ value	0.813845 (rank : 407)	NC score	0.105801 (rank : 546)
Query Neighborhood Hits	495	Target Neighborhood Hits	87	Shared Neighborhood Hits	67
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

CD276_MOUSE
θ value	0.813845 (rank : 408)	NC score	0.296684 (rank : 277)
Query Neighborhood Hits	495	Target Neighborhood Hits	243	Shared Neighborhood Hits	173
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

EPHA1_MOUSE
θ value	0.813845 (rank : 409)	NC score	0.187058 (rank : 389)
Query Neighborhood Hits	495	Target Neighborhood Hits	958	Shared Neighborhood Hits	149
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

GP116_HUMAN
θ value	0.813845 (rank : 410)	NC score	0.088084 (rank : 600)
Query Neighborhood Hits	495	Target Neighborhood Hits	167	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

MUC1_HUMAN
θ value	0.813845 (rank : 411)	NC score	0.018702 (rank : 1145)
Query Neighborhood Hits	495	Target Neighborhood Hits	975	Shared Neighborhood Hits	29
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

AP3B1_MOUSE
θ value	1.06291 (rank : 412)	NC score	0.010257 (rank : 1154)
Query Neighborhood Hits	495	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CSF1R_HUMAN
θ value	1.06291 (rank : 413)	NC score	0.249246 (rank : 330)
Query Neighborhood Hits	495	Target Neighborhood Hits	943	Shared Neighborhood Hits	215
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FANK1_HUMAN
θ value	1.06291 (rank : 414)	NC score	0.036484 (rank : 1132)
Query Neighborhood Hits	495	Target Neighborhood Hits	326	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

GP125_HUMAN
θ value	1.06291 (rank : 415)	NC score	0.089158 (rank : 592)
Query Neighborhood Hits	495	Target Neighborhood Hits	327	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

I27RA_HUMAN
θ value	1.06291 (rank : 416)	NC score	0.180500 (rank : 396)
Query Neighborhood Hits	495	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

UBP7_HUMAN
θ value	1.06291 (rank : 417)	NC score	0.009928 (rank : 1155)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	Q93009	Gene names	USP7, HAUSP
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease).

FPRP_MOUSE
θ value	1.38821 (rank : 418)	NC score	0.126450 (rank : 458)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	73
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

I18RA_MOUSE
θ value	1.38821 (rank : 419)	NC score	0.092441 (rank : 571)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

INGR1_MOUSE
θ value	1.38821 (rank : 420)	NC score	0.028489 (rank : 1140)
Query Neighborhood Hits	495	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	P15261	Gene names	Ifngr1, Ifngr
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen).

KSR1_MOUSE
θ value	1.38821 (rank : 421)	NC score	0.089703 (rank : 587)
Query Neighborhood Hits	495	Target Neighborhood Hits	870	Shared Neighborhood Hits	88
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

LIRB5_HUMAN
θ value	1.38821 (rank : 422)	NC score	0.036609 (rank : 1131)
Query Neighborhood Hits	495	Target Neighborhood Hits	100	Shared Neighborhood Hits	40
SwissProt Accessions	O75023, Q8N760	Gene names	LILRB5, LIR8
Domain Architecture
Description	Leukocyte immunoglobulin-like receptor subfamily B member 5 precursor (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD85c antigen).

LSR_HUMAN
θ value	1.38821 (rank : 423)	NC score	0.026710 (rank : 1141)
Query Neighborhood Hits	495	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

MFA3L_MOUSE
θ value	1.38821 (rank : 424)	NC score	0.443069 (rank : 172)
Query Neighborhood Hits	495	Target Neighborhood Hits	214	Shared Neighborhood Hits	192
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

NTHL1_HUMAN
θ value	1.38821 (rank : 425)	NC score	0.011272 (rank : 1152)
Query Neighborhood Hits	495	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P78549, Q99566, Q99794, Q9BPX2	Gene names	NTHL1, NTH1, OCTS3
Domain Architecture
Description	Endonuclease III-like protein 1 (EC 4.2.99.18).

PGFRL_HUMAN
θ value	1.38821 (rank : 426)	NC score	0.271950 (rank : 301)
Query Neighborhood Hits	495	Target Neighborhood Hits	115	Shared Neighborhood Hits	113
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

SIGL6_HUMAN
θ value	1.38821 (rank : 427)	NC score	0.328657 (rank : 251)
Query Neighborhood Hits	495	Target Neighborhood Hits	233	Shared Neighborhood Hits	205
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

AMGO3_MOUSE
θ value	1.81305 (rank : 428)	NC score	0.113829 (rank : 510)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	82
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ESAM_MOUSE
θ value	1.81305 (rank : 429)	NC score	0.358487 (rank : 226)
Query Neighborhood Hits	495	Target Neighborhood Hits	222	Shared Neighborhood Hits	176
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

I18RA_HUMAN
θ value	1.81305 (rank : 430)	NC score	0.088174 (rank : 598)
Query Neighborhood Hits	495	Target Neighborhood Hits	97	Shared Neighborhood Hits	64
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

LEPR_MOUSE
θ value	1.81305 (rank : 431)	NC score	0.122720 (rank : 474)
Query Neighborhood Hits	495	Target Neighborhood Hits	109	Shared Neighborhood Hits	66
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

PECA1_MOUSE
θ value	1.81305 (rank : 432)	NC score	0.239856 (rank : 344)
Query Neighborhood Hits	495	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

TRIM9_HUMAN
θ value	1.81305 (rank : 433)	NC score	0.078948 (rank : 655)
Query Neighborhood Hits	495	Target Neighborhood Hits	294	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

CD48_HUMAN
θ value	2.36792 (rank : 434)	NC score	0.090682 (rank : 577)
Query Neighborhood Hits	495	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

PK1L1_HUMAN
θ value	2.36792 (rank : 435)	NC score	0.009233 (rank : 1156)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PTPRJ_HUMAN
θ value	2.36792 (rank : 436)	NC score	0.199234 (rank : 376)
Query Neighborhood Hits	495	Target Neighborhood Hits	207	Shared Neighborhood Hits	102
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

TPSNR_HUMAN
θ value	2.36792 (rank : 437)	NC score	0.121706 (rank : 476)
Query Neighborhood Hits	495	Target Neighborhood Hits	330	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

TRIM9_MOUSE
θ value	2.36792 (rank : 438)	NC score	0.069029 (rank : 694)
Query Neighborhood Hits	495	Target Neighborhood Hits	274	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

AMGO1_HUMAN
θ value	3.0926 (rank : 439)	NC score	0.107552 (rank : 542)
Query Neighborhood Hits	495	Target Neighborhood Hits	353	Shared Neighborhood Hits	104
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

FCGR1_HUMAN
θ value	3.0926 (rank : 440)	NC score	0.207035 (rank : 374)
Query Neighborhood Hits	495	Target Neighborhood Hits	145	Shared Neighborhood Hits	108
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

PIGR_HUMAN
θ value	3.0926 (rank : 441)	NC score	0.257089 (rank : 320)
Query Neighborhood Hits	495	Target Neighborhood Hits	164	Shared Neighborhood Hits	108
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PIGR_MOUSE
θ value	3.0926 (rank : 442)	NC score	0.277232 (rank : 294)
Query Neighborhood Hits	495	Target Neighborhood Hits	214	Shared Neighborhood Hits	138
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

RC3H1_HUMAN
θ value	3.0926 (rank : 443)	NC score	0.006563 (rank : 1163)
Query Neighborhood Hits	495	Target Neighborhood Hits	433	Shared Neighborhood Hits	19
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

SIRPG_HUMAN
θ value	3.0926 (rank : 444)	NC score	0.107877 (rank : 541)
Query Neighborhood Hits	495	Target Neighborhood Hits	359	Shared Neighborhood Hits	87
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

BTNL8_HUMAN
θ value	4.03905 (rank : 445)	NC score	0.033374 (rank : 1134)
Query Neighborhood Hits	495	Target Neighborhood Hits	177	Shared Neighborhood Hits	65
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

DGKZ_MOUSE
θ value	4.03905 (rank : 446)	NC score	-0.003717 (rank : 1181)
Query Neighborhood Hits	495	Target Neighborhood Hits	542	Shared Neighborhood Hits	5
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

GP125_MOUSE
θ value	4.03905 (rank : 447)	NC score	0.089597 (rank : 589)
Query Neighborhood Hits	495	Target Neighborhood Hits	329	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

I10R2_HUMAN
θ value	4.03905 (rank : 448)	NC score	0.018904 (rank : 1144)
Query Neighborhood Hits	495	Target Neighborhood Hits	43	Shared Neighborhood Hits	15
SwissProt Accessions	Q08334, Q9BUU4	Gene names	IL10RB, CRFB4
Domain Architecture
Description	Interleukin-10 receptor beta chain precursor (IL-10R-B) (IL-10R2) (Cytokine receptor family 2 member 4) (Cytokine receptor class-II member 4) (CRF2-4) (CDw210b antigen).

IGLL1_HUMAN
θ value	4.03905 (rank : 449)	NC score	0.004911 (rank : 1165)
Query Neighborhood Hits	495	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	P15814	Gene names	IGLL1, IGL1
Domain Architecture
Description	Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin- related protein 14.1) (Immunoglobulin omega polypeptide) (Ig lambda-5) (CD179b antigen).

LEPR_HUMAN
θ value	4.03905 (rank : 450)	NC score	0.118668 (rank : 484)
Query Neighborhood Hits	495	Target Neighborhood Hits	112	Shared Neighborhood Hits	73
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

SIGIR_MOUSE
θ value	4.03905 (rank : 451)	NC score	0.090383 (rank : 578)
Query Neighborhood Hits	495	Target Neighborhood Hits	95	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

SLAF6_MOUSE
θ value	4.03905 (rank : 452)	NC score	0.033827 (rank : 1133)
Query Neighborhood Hits	495	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ET39, Q9ET40	Gene names	Slamf6, Ly108
Domain Architecture	No domain graphic available
Description	SLAM family member 6 precursor (Lymphocyte antigen 108).

AGO61_HUMAN
θ value	5.27518 (rank : 453)	NC score	0.008021 (rank : 1159)
Query Neighborhood Hits	495	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NAT1, Q96SY3	Gene names	AGO61, C3orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized glycosyltransferase AGO61 precursor (EC 2.4.-.-).

AP3B1_HUMAN
θ value	5.27518 (rank : 454)	NC score	0.004100 (rank : 1170)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	10
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ASPN_MOUSE
θ value	5.27518 (rank : 455)	NC score	0.058165 (rank : 854)
Query Neighborhood Hits	495	Target Neighborhood Hits	277	Shared Neighborhood Hits	45
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

CNOT2_HUMAN
θ value	5.27518 (rank : 456)	NC score	0.014040 (rank : 1150)
Query Neighborhood Hits	495	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZN8, Q9H3E0, Q9NSX5, Q9NWR6, Q9P028	Gene names	CNOT2, CDC36, NOT2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

CNOT2_MOUSE
θ value	5.27518 (rank : 457)	NC score	0.011736 (rank : 1151)
Query Neighborhood Hits	495	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C5L3, Q3UE39, Q80YA5, Q9D0P1	Gene names	Cnot2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

DSPP_HUMAN
θ value	5.27518 (rank : 458)	NC score	0.006628 (rank : 1162)
Query Neighborhood Hits	495	Target Neighborhood Hits	645	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

I10R2_MOUSE
θ value	5.27518 (rank : 459)	NC score	0.041790 (rank : 1127)
Query Neighborhood Hits	495	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	Q61190	Gene names	Il10rb, Crfb4
Domain Architecture
Description	Interleukin-10 receptor beta chain precursor (IL-10R-B) (IL-10R2) (Cytokine receptor family 2 member 4) (Cytokine receptor class-II member 4) (CRF2-4) (CDw210b antigen).

ITPR2_MOUSE
θ value	5.27518 (rank : 460)	NC score	0.001066 (rank : 1174)
Query Neighborhood Hits	495	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

K0174_HUMAN
θ value	5.27518 (rank : 461)	NC score	0.006852 (rank : 1161)
Query Neighborhood Hits	495	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P53990, Q9BQ81, Q9BWN2	Gene names	KIAA0174
Domain Architecture
Description	Protein KIAA0174 (Putative MAPK-activating protein PM28).

LIRB4_MOUSE
θ value	5.27518 (rank : 462)	NC score	0.010748 (rank : 1153)
Query Neighborhood Hits	495	Target Neighborhood Hits	56	Shared Neighborhood Hits	19
SwissProt Accessions	Q64281, Q64312	Gene names	Lilrb4, Gp49b
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 4 precursor (Mast cell surface glycoprotein Gp49B).

PCLO_MOUSE
θ value	5.27518 (rank : 463)	NC score	0.018285 (rank : 1147)
Query Neighborhood Hits	495	Target Neighborhood Hits	2275	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TMM25_MOUSE
θ value	5.27518 (rank : 464)	NC score	0.083778 (rank : 630)
Query Neighborhood Hits	495	Target Neighborhood Hits	46	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

AGO61_MOUSE
θ value	6.88961 (rank : 465)	NC score	0.007758 (rank : 1160)
Query Neighborhood Hits	495	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BW41, Q58F17, Q8BXZ9, Q8K0M5	Gene names	Ago61
Domain Architecture	No domain graphic available
Description	Uncharacterized glycosyltransferase AGO61 precursor (EC 2.4.-.-).

AMGO3_HUMAN
θ value	6.88961 (rank : 466)	NC score	0.117101 (rank : 490)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	87
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

DLG1_MOUSE
θ value	6.88961 (rank : 467)	NC score	-0.003942 (rank : 1182)
Query Neighborhood Hits	495	Target Neighborhood Hits	285	Shared Neighborhood Hits	5
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

FA54A_MOUSE
θ value	6.88961 (rank : 468)	NC score	0.004166 (rank : 1169)
Query Neighborhood Hits	495	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VED8	Gene names	Fam54a, Dufd1
Domain Architecture	No domain graphic available
Description	Protein FAM54A (DUF729 domain-containing protein 1).

IGSF2_HUMAN
θ value	6.88961 (rank : 469)	NC score	0.140152 (rank : 431)
Query Neighborhood Hits	495	Target Neighborhood Hits	208	Shared Neighborhood Hits	106
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

IL6RA_HUMAN
θ value	6.88961 (rank : 470)	NC score	0.109951 (rank : 535)
Query Neighborhood Hits	495	Target Neighborhood Hits	96	Shared Neighborhood Hits	61
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

MAP1B_MOUSE
θ value	6.88961 (rank : 471)	NC score	0.001162 (rank : 1173)
Query Neighborhood Hits	495	Target Neighborhood Hits	977	Shared Neighborhood Hits	21
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MGAT2_HUMAN
θ value	6.88961 (rank : 472)	NC score	0.004498 (rank : 1166)
Query Neighborhood Hits	495	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q10469	Gene names	MGAT2
Domain Architecture
Description	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Mannoside acetylglucosaminyltransferase 2) (N- glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II) (Beta-1,2-N-acetylglucosaminyltransferase II) (GNT-II) (GlcNAc-T II).

NOL4_HUMAN
θ value	6.88961 (rank : 473)	NC score	0.008096 (rank : 1158)
Query Neighborhood Hits	495	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	O94818, Q9BWF1	Gene names	NOL4, NOLP
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4 (Nucleolar-localized protein).

NUMBL_MOUSE
θ value	6.88961 (rank : 474)	NC score	0.003838 (rank : 1171)
Query Neighborhood Hits	495	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

TBCD1_HUMAN
θ value	6.88961 (rank : 475)	NC score	-0.001277 (rank : 1178)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	3
SwissProt Accessions	Q86TI0, Q96K82, Q9UPP4	Gene names	TBC1D1, KIAA1108
Domain Architecture
Description	TBC1 domain family member 1.

TRI46_HUMAN
θ value	6.88961 (rank : 476)	NC score	0.016685 (rank : 1149)
Query Neighborhood Hits	495	Target Neighborhood Hits	291	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
θ value	6.88961 (rank : 477)	NC score	0.018478 (rank : 1146)
Query Neighborhood Hits	495	Target Neighborhood Hits	287	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

BAZ2B_HUMAN
θ value	8.99809 (rank : 478)	NC score	-0.004478 (rank : 1183)
Query Neighborhood Hits	495	Target Neighborhood Hits	803	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BBX_HUMAN
θ value	8.99809 (rank : 479)	NC score	-0.000676 (rank : 1175)
Query Neighborhood Hits	495	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY36, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q9H0J6	Gene names	BBX, HBP2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).

DHX57_HUMAN
θ value	8.99809 (rank : 480)	NC score	-0.001050 (rank : 1176)
Query Neighborhood Hits	495	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

DUS2_MOUSE
θ value	8.99809 (rank : 481)	NC score	-0.001969 (rank : 1180)
Query Neighborhood Hits	495	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q05922, Q60640	Gene names	Dusp2, Pac-1, Pac1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

G3BP_MOUSE
θ value	8.99809 (rank : 482)	NC score	-0.001448 (rank : 1179)
Query Neighborhood Hits	495	Target Neighborhood Hits	209	Shared Neighborhood Hits	6
SwissProt Accessions	P97855	Gene names	G3bp, G3bp1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

I13R2_HUMAN
θ value	8.99809 (rank : 483)	NC score	0.032216 (rank : 1137)
Query Neighborhood Hits	495	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q14627, O00667	Gene names	IL13RA2, IL13R
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-2 chain precursor (Interleukin-13- binding protein) (CD213a2 antigen).

JAML1_MOUSE
θ value	8.99809 (rank : 484)	NC score	0.217588 (rank : 363)
Query Neighborhood Hits	495	Target Neighborhood Hits	185	Shared Neighborhood Hits	118
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

LAG3_MOUSE
θ value	8.99809 (rank : 485)	NC score	0.193397 (rank : 382)
Query Neighborhood Hits	495	Target Neighborhood Hits	117	Shared Neighborhood Hits	91
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

MBB1A_HUMAN
θ value	8.99809 (rank : 486)	NC score	0.006006 (rank : 1164)
Query Neighborhood Hits	495	Target Neighborhood Hits	665	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

NUMBL_HUMAN
θ value	8.99809 (rank : 487)	NC score	0.001288 (rank : 1172)
Query Neighborhood Hits	495	Target Neighborhood Hits	394	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

PCLO_HUMAN
θ value	8.99809 (rank : 488)	NC score	0.004284 (rank : 1167)
Query Neighborhood Hits	495	Target Neighborhood Hits	2046	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RP1_MOUSE
θ value	8.99809 (rank : 489)	NC score	0.008256 (rank : 1157)
Query Neighborhood Hits	495	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	P56716	Gene names	Rp1, Orp1, Rp1h
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog).

SLAF8_MOUSE
θ value	8.99809 (rank : 490)	NC score	0.066565 (rank : 709)
Query Neighborhood Hits	495	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D3G2, Q8R3T7	Gene names	Slamf8, Blame
Domain Architecture	No domain graphic available
Description	SLAM family member 8 precursor (B-lymphocyte activator macrophage expressed).

TRI18_HUMAN
θ value	8.99809 (rank : 491)	NC score	0.032618 (rank : 1136)
Query Neighborhood Hits	495	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI42_HUMAN
θ value	8.99809 (rank : 492)	NC score	0.057456 (rank : 873)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI42_MOUSE
θ value	8.99809 (rank : 493)	NC score	0.045901 (rank : 1126)
Query Neighborhood Hits	495	Target Neighborhood Hits	316	Shared Neighborhood Hits	41
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

UROL1_MOUSE
θ value	8.99809 (rank : 494)	NC score	0.020034 (rank : 1143)
Query Neighborhood Hits	495	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	Q5DID3, Q5DID1, Q5DID2	Gene names	Umodl1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

VAV3_MOUSE
θ value	8.99809 (rank : 495)	NC score	-0.001122 (rank : 1177)
Query Neighborhood Hits	495	Target Neighborhood Hits	404	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

A1BG_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.080062 (rank : 648)
Query Neighborhood Hits	495	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

A2GL_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.057063 (rank : 884)
Query Neighborhood Hits	495	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	P02750, Q8N4F5, Q96QZ4	Gene names	LRG1, LRG
Domain Architecture
Description	Leucine-rich alpha-2-glycoprotein precursor (LRG).

AAPK1_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.057691 (rank : 866)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.057426 (rank : 875)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.055565 (rank : 922)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.125903 (rank : 461)
Query Neighborhood Hits	495	Target Neighborhood Hits	1243	Shared Neighborhood Hits	94
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.128660 (rank : 448)
Query Neighborhood Hits	495	Target Neighborhood Hits	942	Shared Neighborhood Hits	89
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.114297 (rank : 502)
Query Neighborhood Hits	495	Target Neighborhood Hits	1220	Shared Neighborhood Hits	91
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.114879 (rank : 495)
Query Neighborhood Hits	495	Target Neighborhood Hits	1178	Shared Neighborhood Hits	95
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.114592 (rank : 498)
Query Neighborhood Hits	495	Target Neighborhood Hits	1045	Shared Neighborhood Hits	90
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.125641 (rank : 463)
Query Neighborhood Hits	495	Target Neighborhood Hits	1140	Shared Neighborhood Hits	94
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.126884 (rank : 457)
Query Neighborhood Hits	495	Target Neighborhood Hits	1080	Shared Neighborhood Hits	93
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.060333 (rank : 798)
Query Neighborhood Hits	495	Target Neighborhood Hits	753	Shared Neighborhood Hits	83
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.060761 (rank : 787)
Query Neighborhood Hits	495	Target Neighborhood Hits	753	Shared Neighborhood Hits	83
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.064709 (rank : 732)
Query Neighborhood Hits	495	Target Neighborhood Hits	709	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.061338 (rank : 776)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.072960 (rank : 677)
Query Neighborhood Hits	495	Target Neighborhood Hits	716	Shared Neighborhood Hits	78
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.076151 (rank : 662)
Query Neighborhood Hits	495	Target Neighborhood Hits	739	Shared Neighborhood Hits	79
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.063948 (rank : 740)
Query Neighborhood Hits	495	Target Neighborhood Hits	760	Shared Neighborhood Hits	82
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.064728 (rank : 731)
Query Neighborhood Hits	495	Target Neighborhood Hits	768	Shared Neighborhood Hits	82
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AGRIN_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.060208 (rank : 802)
Query Neighborhood Hits	495	Target Neighborhood Hits	582	Shared Neighborhood Hits	47
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

AL2S2_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.050249 (rank : 1116)
Query Neighborhood Hits	495	Target Neighborhood Hits	727	Shared Neighborhood Hits	78
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.052185 (rank : 1051)
Query Neighborhood Hits	495	Target Neighborhood Hits	709	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.051779 (rank : 1065)
Query Neighborhood Hits	495	Target Neighborhood Hits	831	Shared Neighborhood Hits	84
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.142167 (rank : 428)
Query Neighborhood Hits	495	Target Neighborhood Hits	795	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.143301 (rank : 426)
Query Neighborhood Hits	495	Target Neighborhood Hits	811	Shared Neighborhood Hits	92
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALS_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.062958 (rank : 753)
Query Neighborhood Hits	495	Target Neighborhood Hits	280	Shared Neighborhood Hits	45
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

ALS_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.061517 (rank : 772)
Query Neighborhood Hits	495	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	P70389, Q9DBI7	Gene names	Igfals, Albs, Als
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

AMGO1_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.088654 (rank : 596)
Query Neighborhood Hits	495	Target Neighborhood Hits	325	Shared Neighborhood Hits	85
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

AMHR2_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.058470 (rank : 838)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	80
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKK1_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.062730 (rank : 756)
Query Neighborhood Hits	495	Target Neighborhood Hits	1075	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.064920 (rank : 727)
Query Neighborhood Hits	495	Target Neighborhood Hits	1072	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.079931 (rank : 651)
Query Neighborhood Hits	495	Target Neighborhood Hits	612	Shared Neighborhood Hits	79
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.079956 (rank : 650)
Query Neighborhood Hits	495	Target Neighborhood Hits	600	Shared Neighborhood Hits	79
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.074480 (rank : 670)
Query Neighborhood Hits	495	Target Neighborhood Hits	646	Shared Neighborhood Hits	79
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.073589 (rank : 675)
Query Neighborhood Hits	495	Target Neighborhood Hits	607	Shared Neighborhood Hits	79
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.092603 (rank : 569)
Query Neighborhood Hits	495	Target Neighborhood Hits	924	Shared Neighborhood Hits	87
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.092942 (rank : 567)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	86
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ASPN_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.056609 (rank : 896)
Query Neighborhood Hits	495	Target Neighborhood Hits	274	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BXN1, Q96K79, Q96LD0, Q9NXP3	Gene names	ASPN, PLAP1
Domain Architecture
Description	Asporin precursor (Periodontal ligament-associated protein 1) (PLAP- 1).

AURKB_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.057530 (rank : 870)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.055575 (rank : 921)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.058777 (rank : 833)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.057868 (rank : 861)
Query Neighborhood Hits	495	Target Neighborhood Hits	844	Shared Neighborhood Hits	85
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AVR2A_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.058176 (rank : 853)
Query Neighborhood Hits	495	Target Neighborhood Hits	767	Shared Neighborhood Hits	81
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.058177 (rank : 852)
Query Neighborhood Hits	495	Target Neighborhood Hits	767	Shared Neighborhood Hits	81
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BLK_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.113209 (rank : 516)
Query Neighborhood Hits	495	Target Neighborhood Hits	994	Shared Neighborhood Hits	87
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.114380 (rank : 501)
Query Neighborhood Hits	495	Target Neighborhood Hits	992	Shared Neighborhood Hits	88
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMPR2_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.063938 (rank : 741)
Query Neighborhood Hits	495	Target Neighborhood Hits	736	Shared Neighborhood Hits	80
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.062374 (rank : 759)
Query Neighborhood Hits	495	Target Neighborhood Hits	738	Shared Neighborhood Hits	80
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.065247 (rank : 723)
Query Neighborhood Hits	495	Target Neighborhood Hits	759	Shared Neighborhood Hits	83
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.065032 (rank : 726)
Query Neighborhood Hits	495	Target Neighborhood Hits	758	Shared Neighborhood Hits	83
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.064346 (rank : 737)
Query Neighborhood Hits	495	Target Neighborhood Hits	760	Shared Neighborhood Hits	81
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.065546 (rank : 721)
Query Neighborhood Hits	495	Target Neighborhood Hits	758	Shared Neighborhood Hits	81
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.114779 (rank : 496)
Query Neighborhood Hits	495	Target Neighborhood Hits	942	Shared Neighborhood Hits	86
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.115725 (rank : 491)
Query Neighborhood Hits	495	Target Neighborhood Hits	912	Shared Neighborhood Hits	87
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.092527 (rank : 570)
Query Neighborhood Hits	495	Target Neighborhood Hits	883	Shared Neighborhood Hits	87
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRSK2_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.050163 (rank : 1119)
Query Neighborhood Hits	495	Target Neighborhood Hits	897	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

BT1A1_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.093491 (rank : 565)
Query Neighborhood Hits	495	Target Neighborhood Hits	252	Shared Neighborhood Hits	123
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT3A1_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.062875 (rank : 755)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	96
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

BT3A2_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.107908 (rank : 540)
Query Neighborhood Hits	495	Target Neighborhood Hits	158	Shared Neighborhood Hits	94
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

BT3A3_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.064655 (rank : 733)
Query Neighborhood Hits	495	Target Neighborhood Hits	233	Shared Neighborhood Hits	101
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

BTK_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.114128 (rank : 504)
Query Neighborhood Hits	495	Target Neighborhood Hits	1026	Shared Neighborhood Hits	90
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.114006 (rank : 506)
Query Neighborhood Hits	495	Target Neighborhood Hits	1017	Shared Neighborhood Hits	90
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTNL1_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.083260 (rank : 632)
Query Neighborhood Hits	495	Target Neighborhood Hits	151	Shared Neighborhood Hits	83
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

CCRK_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.050342 (rank : 1113)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CD180_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.053870 (rank : 993)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	41
SwissProt Accessions	Q99467	Gene names	CD180, LY64, RP105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 64) (Radioprotective 105 kDa protein).

CD180_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.055615 (rank : 919)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	42
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

CD226_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.066158 (rank : 718)
Query Neighborhood Hits	495	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K4F0	Gene names	Cd226, Pta1
Domain Architecture
Description	CD226 antigen precursor (Platelet and T-cell activation antigen 1).

CD244_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.083026 (rank : 634)
Query Neighborhood Hits	495	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

CD2L5_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.058375 (rank : 844)
Query Neighborhood Hits	495	Target Neighborhood Hits	987	Shared Neighborhood Hits	88
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.058402 (rank : 843)
Query Neighborhood Hits	495	Target Neighborhood Hits	1011	Shared Neighborhood Hits	90
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.059818 (rank : 811)
Query Neighborhood Hits	495	Target Neighborhood Hits	1275	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CD33_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.079040 (rank : 653)
Query Neighborhood Hits	495	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	P20138, Q8TD24	Gene names	CD33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3) (gp67).

CD33_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.072632 (rank : 680)
Query Neighborhood Hits	495	Target Neighborhood Hits	45	Shared Neighborhood Hits	27
SwissProt Accessions	Q63994, Q63997	Gene names	Cd33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3).

CD45_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.138754 (rank : 433)
Query Neighborhood Hits	495	Target Neighborhood Hits	178	Shared Neighborhood Hits	51
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

CD48_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.096628 (rank : 555)
Query Neighborhood Hits	495	Target Neighborhood Hits	96	Shared Neighborhood Hits	60
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

CD79A_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.175819 (rank : 401)
Query Neighborhood Hits	495	Target Neighborhood Hits	102	Shared Neighborhood Hits	63
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

CD79B_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.053558 (rank : 1005)
Query Neighborhood Hits	495	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

CD80_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.185905 (rank : 391)
Query Neighborhood Hits	495	Target Neighborhood Hits	136	Shared Neighborhood Hits	105
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

CD86_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.062471 (rank : 757)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	P42081, Q13655, Q7M4L5	Gene names	CD86, CD28LG2
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63).

CD86_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.064852 (rank : 729)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	P42082	Gene names	Cd86
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (Early T-cell costimulatory molecule 1) (ETC-1).

CDC2_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.055300 (rank : 936)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	84
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.055231 (rank : 943)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK2_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.055278 (rank : 938)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.055311 (rank : 935)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	85
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.056770 (rank : 893)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	84
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.051917 (rank : 1057)
Query Neighborhood Hits	495	Target Neighborhood Hits	829	Shared Neighborhood Hits	84
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK4_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.059470 (rank : 818)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	85
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.060911 (rank : 785)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	85
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK5_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.054043 (rank : 985)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	82
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.054138 (rank : 980)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	82
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK6_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.059862 (rank : 810)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.060126 (rank : 806)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK7_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.055693 (rank : 916)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.056122 (rank : 906)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	85
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK9_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.051669 (rank : 1070)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	85
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.051355 (rank : 1083)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	85
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDKL2_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.055519 (rank : 924)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.053661 (rank : 1001)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL3_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.052159 (rank : 1052)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.051668 (rank : 1071)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.051640 (rank : 1072)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	83
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.054369 (rank : 969)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.050629 (rank : 1108)
Query Neighborhood Hits	495	Target Neighborhood Hits	967	Shared Neighborhood Hits	92
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CEA19_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.053590 (rank : 1004)
Query Neighborhood Hits	495	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

CEAM3_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.087029 (rank : 610)
Query Neighborhood Hits	495	Target Neighborhood Hits	28	Shared Neighborhood Hits	24
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

CEAMA_MOUSE
θ value	θ > 10 (rank : 602)	NC score	0.091289 (rank : 576)
Query Neighborhood Hits	495	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

CHAD_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.066539 (rank : 712)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	44
SwissProt Accessions	O15335, Q96RJ5	Gene names	CHAD
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

CHAD_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.064502 (rank : 734)
Query Neighborhood Hits	495	Target Neighborhood Hits	260	Shared Neighborhood Hits	44
SwissProt Accessions	O55226	Gene names	Chad
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

CHK1_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.050802 (rank : 1105)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.050525 (rank : 1111)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	84
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CI096_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.052252 (rank : 1048)
Query Neighborhood Hits	495	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CNTFR_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.074656 (rank : 669)
Query Neighborhood Hits	495	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CNTFR_MOUSE
θ value	θ > 10 (rank : 609)	NC score	0.078986 (rank : 654)
Query Neighborhood Hits	495	Target Neighborhood Hits	74	Shared Neighborhood Hits	50
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CPN2_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.062027 (rank : 765)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	45
SwissProt Accessions	P22792, Q86SU4, Q8N5V4	Gene names	CPN2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

CPN2_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.060993 (rank : 783)
Query Neighborhood Hits	495	Target Neighborhood Hits	291	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

CRLF2_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.057824 (rank : 863)
Query Neighborhood Hits	495	Target Neighborhood Hits	39	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

CSK_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.113523 (rank : 513)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	90
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.111639 (rank : 530)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	90
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPK1_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.054146 (rank : 979)
Query Neighborhood Hits	495	Target Neighborhood Hits	1130	Shared Neighborhood Hits	95
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.053770 (rank : 997)
Query Neighborhood Hits	495	Target Neighborhood Hits	1138	Shared Neighborhood Hits	95
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.061779 (rank : 768)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.062177 (rank : 763)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.062243 (rank : 761)
Query Neighborhood Hits	495	Target Neighborhood Hits	945	Shared Neighborhood Hits	85
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.061378 (rank : 775)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	86
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK1_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.051591 (rank : 1075)
Query Neighborhood Hits	495	Target Neighborhood Hits	877	Shared Neighborhood Hits	87
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.051458 (rank : 1079)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DDR1_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.137667 (rank : 436)
Query Neighborhood Hits	495	Target Neighborhood Hits	819	Shared Neighborhood Hits	87
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 624)	NC score	0.137590 (rank : 437)
Query Neighborhood Hits	495	Target Neighborhood Hits	818	Shared Neighborhood Hits	87
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 625)	NC score	0.134484 (rank : 442)
Query Neighborhood Hits	495	Target Neighborhood Hits	818	Shared Neighborhood Hits	87
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 626)	NC score	0.133335 (rank : 443)
Query Neighborhood Hits	495	Target Neighborhood Hits	813	Shared Neighborhood Hits	87
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

E2AK1_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.056053 (rank : 907)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 628)	NC score	0.055870 (rank : 910)
Query Neighborhood Hits	495	Target Neighborhood Hits	821	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.064769 (rank : 730)
Query Neighborhood Hits	495	Target Neighborhood Hits	856	Shared Neighborhood Hits	84
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.062235 (rank : 762)
Query Neighborhood Hits	495	Target Neighborhood Hits	864	Shared Neighborhood Hits	86
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.059386 (rank : 821)
Query Neighborhood Hits	495	Target Neighborhood Hits	859	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.061548 (rank : 771)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

EGFR_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.123290 (rank : 471)
Query Neighborhood Hits	495	Target Neighborhood Hits	939	Shared Neighborhood Hits	88
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.123802 (rank : 469)
Query Neighborhood Hits	495	Target Neighborhood Hits	927	Shared Neighborhood Hits	92
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EMB_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.145041 (rank : 421)
Query Neighborhood Hits	495	Target Neighborhood Hits	54	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

EMB_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.250653 (rank : 326)
Query Neighborhood Hits	495	Target Neighborhood Hits	83	Shared Neighborhood Hits	79
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

ERBB2_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.125638 (rank : 464)
Query Neighborhood Hits	495	Target Neighborhood Hits	1073	Shared Neighborhood Hits	95
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.125249 (rank : 465)
Query Neighborhood Hits	495	Target Neighborhood Hits	918	Shared Neighborhood Hits	90
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.126125 (rank : 459)
Query Neighborhood Hits	495	Target Neighborhood Hits	918	Shared Neighborhood Hits	87
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.124531 (rank : 467)
Query Neighborhood Hits	495	Target Neighborhood Hits	898	Shared Neighborhood Hits	85
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.124664 (rank : 466)
Query Neighborhood Hits	495	Target Neighborhood Hits	910	Shared Neighborhood Hits	93
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

FAK1_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.127476 (rank : 454)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.127148 (rank : 456)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.127979 (rank : 451)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.127299 (rank : 455)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FCERA_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.207335 (rank : 372)
Query Neighborhood Hits	495	Target Neighborhood Hits	150	Shared Neighborhood Hits	117
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCERA_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.075908 (rank : 664)
Query Neighborhood Hits	495	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCG2A_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.106652 (rank : 545)
Query Neighborhood Hits	495	Target Neighborhood Hits	92	Shared Neighborhood Hits	71
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

FCG2B_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.131788 (rank : 444)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	82
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

FCG2C_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.131250 (rank : 446)
Query Neighborhood Hits	495	Target Neighborhood Hits	118	Shared Neighborhood Hits	83
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

FCG3A_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.071489 (rank : 682)
Query Neighborhood Hits	495	Target Neighborhood Hits	65	Shared Neighborhood Hits	50
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

FCG3B_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.080610 (rank : 645)
Query Neighborhood Hits	495	Target Neighborhood Hits	67	Shared Neighborhood Hits	52
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

FCGR2_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.067751 (rank : 705)
Query Neighborhood Hits	495	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

FCGR3_MOUSE
θ value	θ > 10 (rank : 654)	NC score	0.055461 (rank : 925)
Query Neighborhood Hits	495	Target Neighborhood Hits	98	Shared Neighborhood Hits	45
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

FCN1_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.054184 (rank : 977)
Query Neighborhood Hits	495	Target Neighborhood Hits	147	Shared Neighborhood Hits	13
SwissProt Accessions	O00602, Q92596	Gene names	FCN1
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

FCN1_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.055445 (rank : 926)
Query Neighborhood Hits	495	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

FCN2_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.052081 (rank : 1055)
Query Neighborhood Hits	495	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q15485, Q9UC57	Gene names	FCN2
Domain Architecture
Description	Ficolin-2 precursor (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin B) (Serum lectin p35) (EBP-37) (Hucolin) (L- Ficolin).

FCN3_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.051905 (rank : 1058)
Query Neighborhood Hits	495	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	O75636, Q6IBJ5, Q8WW86	Gene names	FCN3, HAKA1
Domain Architecture
Description	Ficolin-3 precursor (Collagen/fibrinogen domain-containing protein 3) (Collagen/fibrinogen domain-containing lectin 3 p35) (Hakata antigen).

FER_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.117676 (rank : 487)
Query Neighborhood Hits	495	Target Neighborhood Hits	1278	Shared Neighborhood Hits	89
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.120350 (rank : 479)
Query Neighborhood Hits	495	Target Neighborhood Hits	978	Shared Neighborhood Hits	85
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.120322 (rank : 480)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	85
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.112785 (rank : 519)
Query Neighborhood Hits	495	Target Neighborhood Hits	1067	Shared Neighborhood Hits	91
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.112669 (rank : 520)
Query Neighborhood Hits	495	Target Neighborhood Hits	1069	Shared Neighborhood Hits	91
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FLRT1_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.074792 (rank : 668)
Query Neighborhood Hits	495	Target Neighborhood Hits	286	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZU1	Gene names	FLRT1
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT1 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 1).

FLRT2_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.066985 (rank : 707)
Query Neighborhood Hits	495	Target Neighborhood Hits	295	Shared Neighborhood Hits	54
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

FLRT3_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.075192 (rank : 665)
Query Neighborhood Hits	495	Target Neighborhood Hits	281	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

FLT3_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.172034 (rank : 404)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	132
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FMOD_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.050010 (rank : 1123)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	41
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

FPRP_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.135488 (rank : 440)
Query Neighborhood Hits	495	Target Neighborhood Hits	130	Shared Neighborhood Hits	94
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

FRK_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.114036 (rank : 505)
Query Neighborhood Hits	495	Target Neighborhood Hits	1058	Shared Neighborhood Hits	87
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.109326 (rank : 537)
Query Neighborhood Hits	495	Target Neighborhood Hits	1078	Shared Neighborhood Hits	89
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.110175 (rank : 534)
Query Neighborhood Hits	495	Target Neighborhood Hits	1073	Shared Neighborhood Hits	89
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GP124_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.063078 (rank : 752)
Query Neighborhood Hits	495	Target Neighborhood Hits	304	Shared Neighborhood Hits	54
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GP124_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.063194 (rank : 749)
Query Neighborhood Hits	495	Target Neighborhood Hits	423	Shared Neighborhood Hits	59
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GP1BA_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.057450 (rank : 874)
Query Neighborhood Hits	495	Target Neighborhood Hits	407	Shared Neighborhood Hits	47
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

GP1BB_MOUSE
θ value	θ > 10 (rank : 676)	NC score	0.054301 (rank : 972)
Query Neighborhood Hits	495	Target Neighborhood Hits	136	Shared Neighborhood Hits	38
SwissProt Accessions	P56400	Gene names	Gp1bb
Domain Architecture
Description	Platelet glycoprotein Ib beta chain precursor (GP-Ib beta) (GPIbB) (GPIb-beta) (CD42c antigen).

GPIX_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.057305 (rank : 878)
Query Neighborhood Hits	495	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	P14770, Q14445, Q92525	Gene names	GP9
Domain Architecture
Description	Platelet glycoprotein IX precursor (GPIX) (CD42a antigen).

GPV_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.060226 (rank : 801)
Query Neighborhood Hits	495	Target Neighborhood Hits	284	Shared Neighborhood Hits	44
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

GPV_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.062019 (rank : 766)
Query Neighborhood Hits	495	Target Neighborhood Hits	293	Shared Neighborhood Hits	43
SwissProt Accessions	O08742	Gene names	Gp5
Domain Architecture	No domain graphic available
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

GRK4_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.051046 (rank : 1093)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	84
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 681)	NC score	0.052440 (rank : 1044)
Query Neighborhood Hits	495	Target Neighborhood Hits	808	Shared Neighborhood Hits	85
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GUC2C_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.101719 (rank : 548)
Query Neighborhood Hits	495	Target Neighborhood Hits	624	Shared Neighborhood Hits	80
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.079998 (rank : 649)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	84
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 684)	NC score	0.085618 (rank : 618)
Query Neighborhood Hits	495	Target Neighborhood Hits	692	Shared Neighborhood Hits	83
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.099309 (rank : 550)
Query Neighborhood Hits	495	Target Neighborhood Hits	740	Shared Neighborhood Hits	84
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.078927 (rank : 656)
Query Neighborhood Hits	495	Target Neighborhood Hits	644	Shared Neighborhood Hits	79
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCK_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.114663 (rank : 497)
Query Neighborhood Hits	495	Target Neighborhood Hits	1035	Shared Neighborhood Hits	89
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.115002 (rank : 493)
Query Neighborhood Hits	495	Target Neighborhood Hits	1029	Shared Neighborhood Hits	87
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HHLA2_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.208224 (rank : 370)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

HUNK_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.051374 (rank : 1082)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	85
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.051142 (rank : 1089)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

I12R1_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.169317 (rank : 408)
Query Neighborhood Hits	495	Target Neighborhood Hits	78	Shared Neighborhood Hits	64
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

I27RA_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.105125 (rank : 547)
Query Neighborhood Hits	495	Target Neighborhood Hits	55	Shared Neighborhood Hits	41
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

ICAM1_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.140716 (rank : 429)
Query Neighborhood Hits	495	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

ICAM1_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.169517 (rank : 407)
Query Neighborhood Hits	495	Target Neighborhood Hits	99	Shared Neighborhood Hits	86
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

ICAM3_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.147218 (rank : 417)
Query Neighborhood Hits	495	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

ICK_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.060849 (rank : 786)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.060537 (rank : 791)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

ICOSL_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.061101 (rank : 781)
Query Neighborhood Hits	495	Target Neighborhood Hits	70	Shared Neighborhood Hits	46
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

ICOSL_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.083792 (rank : 629)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

IGSF8_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.074422 (rank : 671)
Query Neighborhood Hits	495	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

IGSF8_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.067530 (rank : 706)
Query Neighborhood Hits	495	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

IKKA_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.070264 (rank : 689)
Query Neighborhood Hits	495	Target Neighborhood Hits	863	Shared Neighborhood Hits	85
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.069887 (rank : 691)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	85
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.063640 (rank : 748)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	85
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.063696 (rank : 747)
Query Neighborhood Hits	495	Target Neighborhood Hits	984	Shared Neighborhood Hits	86
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.054754 (rank : 964)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	82
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.054786 (rank : 962)
Query Neighborhood Hits	495	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IL18R_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.055390 (rank : 930)
Query Neighborhood Hits	495	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

IL1AP_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.073047 (rank : 676)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

IL1AP_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.085516 (rank : 620)
Query Neighborhood Hits	495	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

IL1R1_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.263164 (rank : 313)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	122
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

IL1R1_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.244319 (rank : 337)
Query Neighborhood Hits	495	Target Neighborhood Hits	142	Shared Neighborhood Hits	123
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

IL27B_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.095208 (rank : 558)
Query Neighborhood Hits	495	Target Neighborhood Hits	55	Shared Neighborhood Hits	41
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

IL6RA_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.138980 (rank : 432)
Query Neighborhood Hits	495	Target Neighborhood Hits	104	Shared Neighborhood Hits	79
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

ILK1_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.091386 (rank : 575)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	86
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.089348 (rank : 591)
Query Neighborhood Hits	495	Target Neighborhood Hits	848	Shared Neighborhood Hits	86
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.091821 (rank : 574)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	86
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILRL1_MOUSE
θ value	θ > 10 (rank : 719)	NC score	0.181960 (rank : 393)
Query Neighborhood Hits	495	Target Neighborhood Hits	172	Shared Neighborhood Hits	129
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

IRAK1_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.074137 (rank : 672)
Query Neighborhood Hits	495	Target Neighborhood Hits	820	Shared Neighborhood Hits	85
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 721)	NC score	0.073687 (rank : 674)
Query Neighborhood Hits	495	Target Neighborhood Hits	784	Shared Neighborhood Hits	86
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.059283 (rank : 825)
Query Neighborhood Hits	495	Target Neighborhood Hits	714	Shared Neighborhood Hits	69
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.080520 (rank : 646)
Query Neighborhood Hits	495	Target Neighborhood Hits	644	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.086582 (rank : 613)
Query Neighborhood Hits	495	Target Neighborhood Hits	628	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.082816 (rank : 635)
Query Neighborhood Hits	495	Target Neighborhood Hits	816	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.080646 (rank : 644)
Query Neighborhood Hits	495	Target Neighborhood Hits	820	Shared Neighborhood Hits	86
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.113652 (rank : 511)
Query Neighborhood Hits	495	Target Neighborhood Hits	1016	Shared Neighborhood Hits	86
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.114197 (rank : 503)
Query Neighborhood Hits	495	Target Neighborhood Hits	985	Shared Neighborhood Hits	86
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.112167 (rank : 528)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.112202 (rank : 527)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.109404 (rank : 536)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.109097 (rank : 538)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	85
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.110763 (rank : 533)
Query Neighborhood Hits	495	Target Neighborhood Hits	827	Shared Neighborhood Hits	85
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.107234 (rank : 544)
Query Neighborhood Hits	495	Target Neighborhood Hits	821	Shared Neighborhood Hits	85
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

JAML1_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.117434 (rank : 489)
Query Neighborhood Hits	495	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

K0999_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.053647 (rank : 1002)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 737)	NC score	0.053759 (rank : 998)
Query Neighborhood Hits	495	Target Neighborhood Hits	931	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KCC1A_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.054813 (rank : 960)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 739)	NC score	0.054746 (rank : 965)
Query Neighborhood Hits	495	Target Neighborhood Hits	845	Shared Neighborhood Hits	85
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 740)	NC score	0.051484 (rank : 1078)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 741)	NC score	0.051692 (rank : 1069)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 742)	NC score	0.050826 (rank : 1103)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 743)	NC score	0.051008 (rank : 1096)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.051837 (rank : 1063)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.051828 (rank : 1064)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KKCC1_HUMAN
θ value	θ > 10 (rank : 746)	NC score	0.051161 (rank : 1087)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 747)	NC score	0.051025 (rank : 1095)
Query Neighborhood Hits	495	Target Neighborhood Hits	866	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.054052 (rank : 984)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	87
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.053899 (rank : 991)
Query Neighborhood Hits	495	Target Neighborhood Hits	855	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCA_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.051151 (rank : 1088)
Query Neighborhood Hits	495	Target Neighborhood Hits	1067	Shared Neighborhood Hits	88
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.050201 (rank : 1117)
Query Neighborhood Hits	495	Target Neighborhood Hits	1121	Shared Neighborhood Hits	88
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 752)	NC score	0.050465 (rank : 1112)
Query Neighborhood Hits	495	Target Neighborhood Hits	1117	Shared Neighborhood Hits	88
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD_HUMAN
θ value	θ > 10 (rank : 753)	NC score	0.054640 (rank : 967)
Query Neighborhood Hits	495	Target Neighborhood Hits	900	Shared Neighborhood Hits	86
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.053744 (rank : 1000)
Query Neighborhood Hits	495	Target Neighborhood Hits	888	Shared Neighborhood Hits	86
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.053201 (rank : 1020)
Query Neighborhood Hits	495	Target Neighborhood Hits	897	Shared Neighborhood Hits	86
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.052587 (rank : 1039)
Query Neighborhood Hits	495	Target Neighborhood Hits	895	Shared Neighborhood Hits	86
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPSH1_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.051446 (rank : 1080)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.051537 (rank : 1076)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	85
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.054853 (rank : 956)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	85
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KR171_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.057138 (rank : 881)
Query Neighborhood Hits	495	Target Neighborhood Hits	144	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

KRA51_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.056872 (rank : 891)
Query Neighborhood Hits	495	Target Neighborhood Hits	288	Shared Neighborhood Hits	21
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA53_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.050842 (rank : 1102)
Query Neighborhood Hits	495	Target Neighborhood Hits	331	Shared Neighborhood Hits	24
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KS6A1_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.059282 (rank : 826)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.056505 (rank : 900)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.059421 (rank : 820)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	85
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.059027 (rank : 830)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.060044 (rank : 808)
Query Neighborhood Hits	495	Target Neighborhood Hits	859	Shared Neighborhood Hits	85
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.060011 (rank : 809)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A6_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.058061 (rank : 856)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.050007 (rank : 1124)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KSR1_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.088798 (rank : 593)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR2_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.077634 (rank : 661)
Query Neighborhood Hits	495	Target Neighborhood Hits	920	Shared Neighborhood Hits	86
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.122885 (rank : 472)
Query Neighborhood Hits	495	Target Neighborhood Hits	901	Shared Neighborhood Hits	86
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.122751 (rank : 473)
Query Neighborhood Hits	495	Target Neighborhood Hits	944	Shared Neighborhood Hits	87
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAG3_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.166547 (rank : 409)
Query Neighborhood Hits	495	Target Neighborhood Hits	129	Shared Neighborhood Hits	81
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LAMA1_MOUSE
θ value	θ > 10 (rank : 776)	NC score	0.050322 (rank : 1114)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	45
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LAMA5_HUMAN
θ value	θ > 10 (rank : 777)	NC score	0.060327 (rank : 799)
Query Neighborhood Hits	495	Target Neighborhood Hits	976	Shared Neighborhood Hits	58
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMA5_MOUSE
θ value	θ > 10 (rank : 778)	NC score	0.061482 (rank : 773)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LCK_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.114390 (rank : 499)
Query Neighborhood Hits	495	Target Neighborhood Hits	987	Shared Neighborhood Hits	88
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.113971 (rank : 507)
Query Neighborhood Hits	495	Target Neighborhood Hits	981	Shared Neighborhood Hits	86
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LGI1_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.054818 (rank : 959)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	44
SwissProt Accessions	O95970, Q5W001, Q5W002, Q8NI23, Q96LF5	Gene names	LGI1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor (Epitempin-1).

LGI1_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.055087 (rank : 950)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JIA1	Gene names	Lgi1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor.

LGI2_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.055088 (rank : 949)
Query Neighborhood Hits	495	Target Neighborhood Hits	232	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N0V4, Q8NDW6, Q96PX2, Q9NVK4	Gene names	LGI2, KIAA1916, LGIL2
Domain Architecture
Description	Leucine-rich repeat LGI family member 2 precursor (Leucine-rich glioma-inactivated protein 2) (LGI1-like protein 2).

LGI3_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.054681 (rank : 966)
Query Neighborhood Hits	495	Target Neighborhood Hits	228	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N145, Q86TL4, Q8N296	Gene names	LGI3, LGIL4
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (LGI1-like protein 4).

LGI3_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.053607 (rank : 1003)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

LGI4_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.058247 (rank : 849)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N135	Gene names	LGI4, LGIL3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

LGI4_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.055278 (rank : 939)
Query Neighborhood Hits	495	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1S1, Q8K4Y8	Gene names	Lgi4, Lgil3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

LGR4_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.052370 (rank : 1047)
Query Neighborhood Hits	495	Target Neighborhood Hits	481	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

LGR5_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.053435 (rank : 1013)
Query Neighborhood Hits	495	Target Neighborhood Hits	452	Shared Neighborhood Hits	44
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

LGR5_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.052717 (rank : 1035)
Query Neighborhood Hits	495	Target Neighborhood Hits	484	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1P4	Gene names	Lgr5, Fex, Gpr49
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX).

LGR6_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.052187 (rank : 1050)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

LIMK1_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.085062 (rank : 622)
Query Neighborhood Hits	495	Target Neighborhood Hits	1005	Shared Neighborhood Hits	86
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 793)	NC score	0.084960 (rank : 623)
Query Neighborhood Hits	495	Target Neighborhood Hits	1008	Shared Neighborhood Hits	86
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.084380 (rank : 626)
Query Neighborhood Hits	495	Target Neighborhood Hits	986	Shared Neighborhood Hits	85
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 795)	NC score	0.084271 (rank : 628)
Query Neighborhood Hits	495	Target Neighborhood Hits	998	Shared Neighborhood Hits	85
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LR37A_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.053750 (rank : 999)
Query Neighborhood Hits	495	Target Neighborhood Hits	720	Shared Neighborhood Hits	58
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

LR37B_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.054169 (rank : 978)
Query Neighborhood Hits	495	Target Neighborhood Hits	392	Shared Neighborhood Hits	47
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

LRC15_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.061641 (rank : 770)
Query Neighborhood Hits	495	Target Neighborhood Hits	305	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

LRC15_MOUSE
θ value	θ > 10 (rank : 799)	NC score	0.063850 (rank : 745)
Query Neighborhood Hits	495	Target Neighborhood Hits	305	Shared Neighborhood Hits	44
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

LRC17_HUMAN
θ value	θ > 10 (rank : 800)	NC score	0.055298 (rank : 937)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

LRC17_MOUSE
θ value	θ > 10 (rank : 801)	NC score	0.058926 (rank : 832)
Query Neighborhood Hits	495	Target Neighborhood Hits	268	Shared Neighborhood Hits	44
SwissProt Accessions	Q9CXD9	Gene names	Lrrc17
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor.

LRC19_HUMAN
θ value	θ > 10 (rank : 802)	NC score	0.054338 (rank : 971)
Query Neighborhood Hits	495	Target Neighborhood Hits	217	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H756	Gene names	LRRC19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC19_MOUSE
θ value	θ > 10 (rank : 803)	NC score	0.057072 (rank : 883)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZT5, Q6P8J1	Gene names	Lrrc19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC32_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.056380 (rank : 902)
Query Neighborhood Hits	495	Target Neighborhood Hits	303	Shared Neighborhood Hits	44
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

LRC33_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.054080 (rank : 983)
Query Neighborhood Hits	495	Target Neighborhood Hits	293	Shared Neighborhood Hits	42
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC33_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.051416 (rank : 1081)
Query Neighborhood Hits	495	Target Neighborhood Hits	296	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC3B_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.051135 (rank : 1090)
Query Neighborhood Hits	495	Target Neighborhood Hits	215	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PB8	Gene names	LRRC3B, LRP15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

LRC3B_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.051218 (rank : 1085)
Query Neighborhood Hits	495	Target Neighborhood Hits	215	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VCH9	Gene names	Lrrc3b, Lrp15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

LRC52_HUMAN
θ value	θ > 10 (rank : 809)	NC score	0.058988 (rank : 831)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N7C0, Q5T9K5	Gene names	LRRC52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC52_MOUSE
θ value	θ > 10 (rank : 810)	NC score	0.058329 (rank : 845)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	44
SwissProt Accessions	Q5M8M9	Gene names	Lrrc52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC55_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.057495 (rank : 871)
Query Neighborhood Hits	495	Target Neighborhood Hits	257	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZSA7	Gene names	LRRC55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

LRC55_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.057934 (rank : 859)
Query Neighborhood Hits	495	Target Neighborhood Hits	254	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UY51	Gene names	Lrrc55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

LRRC3_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.053337 (rank : 1016)
Query Neighborhood Hits	495	Target Neighborhood Hits	232	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BY71	Gene names	LRRC3, C21orf102
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

LRRC3_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.058743 (rank : 834)
Query Neighborhood Hits	495	Target Neighborhood Hits	236	Shared Neighborhood Hits	43
SwissProt Accessions	P59034	Gene names	Lrrc3
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

LRRK1_HUMAN
θ value	θ > 10 (rank : 815)	NC score	0.094494 (rank : 560)
Query Neighborhood Hits	495	Target Neighborhood Hits	1237	Shared Neighborhood Hits	126
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 816)	NC score	0.097154 (rank : 554)
Query Neighborhood Hits	495	Target Neighborhood Hits	1267	Shared Neighborhood Hits	128
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.082588 (rank : 636)
Query Neighborhood Hits	495	Target Neighborhood Hits	1382	Shared Neighborhood Hits	121
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 818)	NC score	0.080733 (rank : 641)
Query Neighborhood Hits	495	Target Neighborhood Hits	1359	Shared Neighborhood Hits	124
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LRTM1_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.058434 (rank : 841)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UE6, Q96DN1	Gene names	LRRTM1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

LRTM1_MOUSE
θ value	θ > 10 (rank : 820)	NC score	0.059567 (rank : 815)
Query Neighborhood Hits	495	Target Neighborhood Hits	264	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K377, Q3UVX1	Gene names	Lrrtm1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

LRTM2_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.058460 (rank : 840)
Query Neighborhood Hits	495	Target Neighborhood Hits	282	Shared Neighborhood Hits	44
SwissProt Accessions	O43300, Q7L770	Gene names	LRRTM2, KIAA0416, LRRN2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor (Leucine-rich repeat neuronal 2 protein).

LRTM2_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.058411 (rank : 842)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGA3, Q80U08	Gene names	Lrrtm2, Kiaa0416
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor.

LRTM3_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.057261 (rank : 879)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	44
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

LRTM3_MOUSE
θ value	θ > 10 (rank : 824)	NC score	0.056645 (rank : 894)
Query Neighborhood Hits	495	Target Neighborhood Hits	290	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

LRTM4_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.058197 (rank : 850)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

LRTM4_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.058704 (rank : 835)
Query Neighborhood Hits	495	Target Neighborhood Hits	284	Shared Neighborhood Hits	46
SwissProt Accessions	Q80XG9, Q8C030, Q8JZS8	Gene names	Lrrtm4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

LTK_HUMAN
θ value	θ > 10 (rank : 827)	NC score	0.144962 (rank : 422)
Query Neighborhood Hits	495	Target Neighborhood Hits	774	Shared Neighborhood Hits	87
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.144738 (rank : 423)
Query Neighborhood Hits	495	Target Neighborhood Hits	770	Shared Neighborhood Hits	85
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LY9_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.060144 (rank : 805)
Query Neighborhood Hits	495	Target Neighborhood Hits	82	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

LY9_MOUSE
θ value	θ > 10 (rank : 830)	NC score	0.110992 (rank : 532)
Query Neighborhood Hits	495	Target Neighborhood Hits	110	Shared Neighborhood Hits	74
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

LYN_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.112411 (rank : 524)
Query Neighborhood Hits	495	Target Neighborhood Hits	1022	Shared Neighborhood Hits	86
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 832)	NC score	0.112656 (rank : 521)
Query Neighborhood Hits	495	Target Neighborhood Hits	1023	Shared Neighborhood Hits	88
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.094094 (rank : 563)
Query Neighborhood Hits	495	Target Neighborhood Hits	1071	Shared Neighborhood Hits	91
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.093566 (rank : 564)
Query Neighborhood Hits	495	Target Neighborhood Hits	1136	Shared Neighborhood Hits	96
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.094493 (rank : 561)
Query Neighborhood Hits	495	Target Neighborhood Hits	940	Shared Neighborhood Hits	89
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 836)	NC score	0.094672 (rank : 559)
Query Neighborhood Hits	495	Target Neighborhood Hits	957	Shared Neighborhood Hits	91
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.092188 (rank : 572)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	86
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K15_HUMAN
θ value	θ > 10 (rank : 838)	NC score	0.058297 (rank : 847)
Query Neighborhood Hits	495	Target Neighborhood Hits	914	Shared Neighborhood Hits	86
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 839)	NC score	0.057626 (rank : 867)
Query Neighborhood Hits	495	Target Neighborhood Hits	952	Shared Neighborhood Hits	89
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K3_HUMAN
θ value	θ > 10 (rank : 840)	NC score	0.053174 (rank : 1024)
Query Neighborhood Hits	495	Target Neighborhood Hits	885	Shared Neighborhood Hits	86
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 841)	NC score	0.053041 (rank : 1027)
Query Neighborhood Hits	495	Target Neighborhood Hits	876	Shared Neighborhood Hits	86
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 842)	NC score	0.051732 (rank : 1068)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 843)	NC score	0.050804 (rank : 1104)
Query Neighborhood Hits	495	Target Neighborhood Hits	924	Shared Neighborhood Hits	85
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 844)	NC score	0.057948 (rank : 858)
Query Neighborhood Hits	495	Target Neighborhood Hits	868	Shared Neighborhood Hits	85
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 845)	NC score	0.058146 (rank : 855)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	85
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 846)	NC score	0.055375 (rank : 932)
Query Neighborhood Hits	495	Target Neighborhood Hits	889	Shared Neighborhood Hits	88
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K7_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.090019 (rank : 583)
Query Neighborhood Hits	495	Target Neighborhood Hits	892	Shared Neighborhood Hits	85
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 848)	NC score	0.090070 (rank : 582)
Query Neighborhood Hits	495	Target Neighborhood Hits	892	Shared Neighborhood Hits	85
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.053414 (rank : 1015)
Query Neighborhood Hits	495	Target Neighborhood Hits	807	Shared Neighborhood Hits	78
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 850)	NC score	0.051537 (rank : 1077)
Query Neighborhood Hits	495	Target Neighborhood Hits	815	Shared Neighborhood Hits	78
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K9_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.094098 (rank : 562)
Query Neighborhood Hits	495	Target Neighborhood Hits	1123	Shared Neighborhood Hits	92
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.097898 (rank : 553)
Query Neighborhood Hits	495	Target Neighborhood Hits	1087	Shared Neighborhood Hits	90
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.054249 (rank : 975)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	85
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.054240 (rank : 976)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	87
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K3_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.051270 (rank : 1084)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K4_HUMAN
θ value	θ > 10 (rank : 856)	NC score	0.051030 (rank : 1094)
Query Neighborhood Hits	495	Target Neighborhood Hits	1589	Shared Neighborhood Hits	88
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 857)	NC score	0.054831 (rank : 958)
Query Neighborhood Hits	495	Target Neighborhood Hits	1560	Shared Neighborhood Hits	87
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MAK_HUMAN
θ value	θ > 10 (rank : 858)	NC score	0.061457 (rank : 774)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	84
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 859)	NC score	0.062071 (rank : 764)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	85
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAMC2_HUMAN
θ value	θ > 10 (rank : 860)	NC score	0.050885 (rank : 1100)
Query Neighborhood Hits	495	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAMC2_MOUSE
θ value	θ > 10 (rank : 861)	NC score	0.050728 (rank : 1107)
Query Neighborhood Hits	495	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MARK1_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.055770 (rank : 913)
Query Neighborhood Hits	495	Target Neighborhood Hits	887	Shared Neighborhood Hits	88
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.055342 (rank : 934)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.055885 (rank : 909)
Query Neighborhood Hits	495	Target Neighborhood Hits	1056	Shared Neighborhood Hits	95
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 865)	NC score	0.054287 (rank : 973)
Query Neighborhood Hits	495	Target Neighborhood Hits	1018	Shared Neighborhood Hits	92
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.055735 (rank : 915)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	87
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.054837 (rank : 957)
Query Neighborhood Hits	495	Target Neighborhood Hits	919	Shared Neighborhood Hits	85
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.053507 (rank : 1009)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	86
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 869)	NC score	0.053462 (rank : 1012)
Query Neighborhood Hits	495	Target Neighborhood Hits	898	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MATK_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.119140 (rank : 482)
Query Neighborhood Hits	495	Target Neighborhood Hits	954	Shared Neighborhood Hits	86
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 871)	NC score	0.118400 (rank : 485)
Query Neighborhood Hits	495	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MEGF6_HUMAN
θ value	θ > 10 (rank : 872)	NC score	0.052817 (rank : 1033)
Query Neighborhood Hits	495	Target Neighborhood Hits	671	Shared Neighborhood Hits	56
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

MEGF9_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.057726 (rank : 864)
Query Neighborhood Hits	495	Target Neighborhood Hits	557	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MEGF9_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.055521 (rank : 923)
Query Neighborhood Hits	495	Target Neighborhood Hits	896	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MELK_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.051859 (rank : 1061)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 876)	NC score	0.052532 (rank : 1041)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MET_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.127748 (rank : 453)
Query Neighborhood Hits	495	Target Neighborhood Hits	831	Shared Neighborhood Hits	85
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.127830 (rank : 452)
Query Neighborhood Hits	495	Target Neighborhood Hits	844	Shared Neighborhood Hits	85
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MFAP3_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.145752 (rank : 420)
Query Neighborhood Hits	495	Target Neighborhood Hits	91	Shared Neighborhood Hits	82
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MFAP3_MOUSE
θ value	θ > 10 (rank : 880)	NC score	0.125705 (rank : 462)
Query Neighborhood Hits	495	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

MINK1_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.055439 (rank : 928)
Query Neighborhood Hits	495	Target Neighborhood Hits	1477	Shared Neighborhood Hits	92
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 882)	NC score	0.055365 (rank : 933)
Query Neighborhood Hits	495	Target Neighborhood Hits	1451	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
θ value	θ > 10 (rank : 883)	NC score	0.053902 (rank : 990)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	85
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.053938 (rank : 989)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	85
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.053514 (rank : 1008)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	84
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.053185 (rank : 1023)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.052784 (rank : 1034)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	81
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 888)	NC score	0.051750 (rank : 1066)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK07_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.055792 (rank : 912)
Query Neighborhood Hits	495	Target Neighborhood Hits	1087	Shared Neighborhood Hits	96
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.056313 (rank : 904)
Query Neighborhood Hits	495	Target Neighborhood Hits	1054	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK11_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.051089 (rank : 1092)
Query Neighborhood Hits	495	Target Neighborhood Hits	823	Shared Neighborhood Hits	83
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK12_HUMAN
θ value	θ > 10 (rank : 892)	NC score	0.050916 (rank : 1098)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	θ > 10 (rank : 893)	NC score	0.050117 (rank : 1121)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	85
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK13_HUMAN
θ value	θ > 10 (rank : 894)	NC score	0.050878 (rank : 1101)
Query Neighborhood Hits	495	Target Neighborhood Hits	829	Shared Neighborhood Hits	84
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	θ > 10 (rank : 895)	NC score	0.050792 (rank : 1106)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.050290 (rank : 1115)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK15_HUMAN
θ value	θ > 10 (rank : 897)	NC score	0.051959 (rank : 1056)
Query Neighborhood Hits	495	Target Neighborhood Hits	1038	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MLKL_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.098921 (rank : 551)
Query Neighborhood Hits	495	Target Neighborhood Hits	600	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 899)	NC score	0.093244 (rank : 566)
Query Neighborhood Hits	495	Target Neighborhood Hits	707	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 900)	NC score	0.095358 (rank : 557)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.095505 (rank : 556)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.088216 (rank : 597)
Query Neighborhood Hits	495	Target Neighborhood Hits	829	Shared Neighborhood Hits	85
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 903)	NC score	0.083235 (rank : 633)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	86
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOX2R_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.131366 (rank : 445)
Query Neighborhood Hits	495	Target Neighborhood Hits	51	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MP2K1_HUMAN
θ value	θ > 10 (rank : 905)	NC score	0.052995 (rank : 1028)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	84
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 906)	NC score	0.052946 (rank : 1029)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	84
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.053191 (rank : 1021)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.052193 (rank : 1049)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	84
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.053949 (rank : 988)
Query Neighborhood Hits	495	Target Neighborhood Hits	825	Shared Neighborhood Hits	84
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.052822 (rank : 1032)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	84
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.054764 (rank : 963)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 912)	NC score	0.054788 (rank : 961)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.064487 (rank : 735)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	86
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 914)	NC score	0.065126 (rank : 725)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 915)	NC score	0.054983 (rank : 953)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 916)	NC score	0.054269 (rank : 974)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 917)	NC score	0.055238 (rank : 942)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	84
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 918)	NC score	0.068152 (rank : 700)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 919)	NC score	0.068037 (rank : 703)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYLK2_HUMAN
θ value	θ > 10 (rank : 920)	NC score	0.066472 (rank : 714)
Query Neighborhood Hits	495	Target Neighborhood Hits	920	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NAGPA_HUMAN
θ value	θ > 10 (rank : 921)	NC score	0.057996 (rank : 857)
Query Neighborhood Hits	495	Target Neighborhood Hits	282	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NAGPA_MOUSE
θ value	θ > 10 (rank : 922)	NC score	0.060989 (rank : 784)
Query Neighborhood Hits	495	Target Neighborhood Hits	308	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NEK11_HUMAN
θ value	θ > 10 (rank : 923)	NC score	0.068939 (rank : 695)
Query Neighborhood Hits	495	Target Neighborhood Hits	1043	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 924)	NC score	0.070065 (rank : 690)
Query Neighborhood Hits	495	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 925)	NC score	0.059370 (rank : 822)
Query Neighborhood Hits	495	Target Neighborhood Hits	1129	Shared Neighborhood Hits	88
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 926)	NC score	0.059653 (rank : 814)
Query Neighborhood Hits	495	Target Neighborhood Hits	1311	Shared Neighborhood Hits	97
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 927)	NC score	0.058271 (rank : 848)
Query Neighborhood Hits	495	Target Neighborhood Hits	908	Shared Neighborhood Hits	87
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 928)	NC score	0.055148 (rank : 946)
Query Neighborhood Hits	495	Target Neighborhood Hits	876	Shared Neighborhood Hits	85
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 929)	NC score	0.060203 (rank : 803)
Query Neighborhood Hits	495	Target Neighborhood Hits	865	Shared Neighborhood Hits	85
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 930)	NC score	0.059544 (rank : 816)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 931)	NC score	0.065718 (rank : 720)
Query Neighborhood Hits	495	Target Neighborhood Hits	883	Shared Neighborhood Hits	85
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 932)	NC score	0.065383 (rank : 722)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 933)	NC score	0.066364 (rank : 715)
Query Neighborhood Hits	495	Target Neighborhood Hits	848	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 934)	NC score	0.066246 (rank : 716)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 935)	NC score	0.068050 (rank : 702)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 936)	NC score	0.068054 (rank : 701)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 937)	NC score	0.056892 (rank : 889)
Query Neighborhood Hits	495	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 938)	NC score	0.056892 (rank : 890)
Query Neighborhood Hits	495	Target Neighborhood Hits	872	Shared Neighborhood Hits	86
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 939)	NC score	0.059481 (rank : 817)
Query Neighborhood Hits	495	Target Neighborhood Hits	900	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 940)	NC score	0.058465 (rank : 839)
Query Neighborhood Hits	495	Target Neighborhood Hits	890	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NIM1_HUMAN
θ value	θ > 10 (rank : 941)	NC score	0.054974 (rank : 954)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	86
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 942)	NC score	0.052830 (rank : 1031)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NLK_HUMAN
θ value	θ > 10 (rank : 943)	NC score	0.055033 (rank : 951)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	θ > 10 (rank : 944)	NC score	0.055025 (rank : 952)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	86
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NRK_HUMAN
θ value	θ > 10 (rank : 945)	NC score	0.055266 (rank : 940)
Query Neighborhood Hits	495	Target Neighborhood Hits	931	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 946)	NC score	0.051628 (rank : 1073)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NTRK1_HUMAN
θ value	θ > 10 (rank : 947)	NC score	0.197171 (rank : 379)
Query Neighborhood Hits	495	Target Neighborhood Hits	1023	Shared Neighborhood Hits	197
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NUAK1_HUMAN
θ value	θ > 10 (rank : 948)	NC score	0.057845 (rank : 862)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 949)	NC score	0.057495 (rank : 872)
Query Neighborhood Hits	495	Target Neighborhood Hits	881	Shared Neighborhood Hits	85
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 950)	NC score	0.059322 (rank : 823)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 951)	NC score	0.057571 (rank : 868)
Query Neighborhood Hits	495	Target Neighborhood Hits	878	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

NYX_HUMAN
θ value	θ > 10 (rank : 952)	NC score	0.065817 (rank : 719)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	Q9GZU5, Q5H983, Q9H4J0	Gene names	NYX, CLRP
Domain Architecture
Description	Nyctalopin precursor.

NYX_MOUSE
θ value	θ > 10 (rank : 953)	NC score	0.066545 (rank : 711)
Query Neighborhood Hits	495	Target Neighborhood Hits	241	Shared Neighborhood Hits	44
SwissProt Accessions	P83503, Q8BYN4	Gene names	Nyx
Domain Architecture
Description	Nyctalopin precursor.

OX2G_HUMAN
θ value	θ > 10 (rank : 954)	NC score	0.172360 (rank : 403)
Query Neighborhood Hits	495	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

OX2G_MOUSE
θ value	θ > 10 (rank : 955)	NC score	0.188299 (rank : 388)
Query Neighborhood Hits	495	Target Neighborhood Hits	105	Shared Neighborhood Hits	90
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

OXSR1_HUMAN
θ value	θ > 10 (rank : 956)	NC score	0.060423 (rank : 795)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 957)	NC score	0.060068 (rank : 807)
Query Neighborhood Hits	495	Target Neighborhood Hits	865	Shared Neighborhood Hits	85
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 958)	NC score	0.054130 (rank : 981)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	88
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 959)	NC score	0.053965 (rank : 987)
Query Neighborhood Hits	495	Target Neighborhood Hits	878	Shared Neighborhood Hits	88
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 960)	NC score	0.053997 (rank : 986)
Query Neighborhood Hits	495	Target Neighborhood Hits	862	Shared Neighborhood Hits	86
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 961)	NC score	0.054110 (rank : 982)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 962)	NC score	0.052546 (rank : 1040)
Query Neighborhood Hits	495	Target Neighborhood Hits	887	Shared Neighborhood Hits	85
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 963)	NC score	0.052643 (rank : 1037)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 964)	NC score	0.055444 (rank : 927)
Query Neighborhood Hits	495	Target Neighborhood Hits	924	Shared Neighborhood Hits	89
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 965)	NC score	0.056512 (rank : 898)
Query Neighborhood Hits	495	Target Neighborhood Hits	1098	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 966)	NC score	0.059299 (rank : 824)
Query Neighborhood Hits	495	Target Neighborhood Hits	915	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 967)	NC score	0.057929 (rank : 860)
Query Neighborhood Hits	495	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 968)	NC score	0.057537 (rank : 869)
Query Neighborhood Hits	495	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PCTK1_HUMAN
θ value	θ > 10 (rank : 969)	NC score	0.053080 (rank : 1026)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	84
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 970)	NC score	0.053469 (rank : 1011)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 971)	NC score	0.053790 (rank : 996)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	83
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 972)	NC score	0.053893 (rank : 992)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 973)	NC score	0.051876 (rank : 1060)
Query Neighborhood Hits	495	Target Neighborhood Hits	827	Shared Neighborhood Hits	82
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 974)	NC score	0.052460 (rank : 1043)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	82
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDL1_HUMAN
θ value	θ > 10 (rank : 975)	NC score	0.289795 (rank : 281)
Query Neighborhood Hits	495	Target Neighborhood Hits	195	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL1_MOUSE
θ value	θ > 10 (rank : 976)	NC score	0.227162 (rank : 354)
Query Neighborhood Hits	495	Target Neighborhood Hits	168	Shared Neighborhood Hits	121
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL2_HUMAN
θ value	θ > 10 (rank : 977)	NC score	0.171071 (rank : 405)
Query Neighborhood Hits	495	Target Neighborhood Hits	114	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PDPK1_HUMAN
θ value	θ > 10 (rank : 978)	NC score	0.053258 (rank : 1017)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	θ > 10 (rank : 979)	NC score	0.053470 (rank : 1010)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PFTK1_HUMAN
θ value	θ > 10 (rank : 980)	NC score	0.051840 (rank : 1062)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	85
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 981)	NC score	0.051742 (rank : 1067)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	85
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PGS1_HUMAN
θ value	θ > 10 (rank : 982)	NC score	0.055751 (rank : 914)
Query Neighborhood Hits	495	Target Neighborhood Hits	261	Shared Neighborhood Hits	43
SwissProt Accessions	P21810, P13247	Gene names	BGN
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

PGS1_MOUSE
θ value	θ > 10 (rank : 983)	NC score	0.055842 (rank : 911)
Query Neighborhood Hits	495	Target Neighborhood Hits	265	Shared Neighborhood Hits	43
SwissProt Accessions	P28653, Q61355	Gene names	Bgn
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

PGS2_HUMAN
θ value	θ > 10 (rank : 984)	NC score	0.053521 (rank : 1007)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	43
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

PGS2_MOUSE
θ value	θ > 10 (rank : 985)	NC score	0.054625 (rank : 968)
Query Neighborhood Hits	495	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

PINK1_HUMAN
θ value	θ > 10 (rank : 986)	NC score	0.052094 (rank : 1054)
Query Neighborhood Hits	495	Target Neighborhood Hits	741	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 987)	NC score	0.055622 (rank : 918)
Query Neighborhood Hits	495	Target Neighborhood Hits	726	Shared Neighborhood Hits	78
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKD1_HUMAN
θ value	θ > 10 (rank : 988)	NC score	0.059202 (rank : 828)
Query Neighborhood Hits	495	Target Neighborhood Hits	387	Shared Neighborhood Hits	51
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PKN1_HUMAN
θ value	θ > 10 (rank : 989)	NC score	0.058322 (rank : 846)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	85
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 990)	NC score	0.058569 (rank : 837)
Query Neighborhood Hits	495	Target Neighborhood Hits	888	Shared Neighborhood Hits	85
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 991)	NC score	0.055377 (rank : 931)
Query Neighborhood Hits	495	Target Neighborhood Hits	892	Shared Neighborhood Hits	85
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 992)	NC score	0.055139 (rank : 947)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 993)	NC score	0.055203 (rank : 944)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	90
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 994)	NC score	0.056305 (rank : 905)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	88
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 995)	NC score	0.056869 (rank : 892)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 996)	NC score	0.054355 (rank : 970)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 997)	NC score	0.057022 (rank : 885)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 998)	NC score	0.057172 (rank : 880)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 999)	NC score	0.055638 (rank : 917)
Query Neighborhood Hits	495	Target Neighborhood Hits	865	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 1000)	NC score	0.056613 (rank : 895)
Query Neighborhood Hits	495	Target Neighborhood Hits	863	Shared Neighborhood Hits	85
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 1001)	NC score	0.059443 (rank : 819)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	88
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 1002)	NC score	0.059804 (rank : 812)
Query Neighborhood Hits	495	Target Neighborhood Hits	879	Shared Neighborhood Hits	85
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PP1R7_HUMAN
θ value	θ > 10 (rank : 1003)	NC score	0.051121 (rank : 1091)
Query Neighborhood Hits	495	Target Neighborhood Hits	265	Shared Neighborhood Hits	36
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

PRKX_MOUSE
θ value	θ > 10 (rank : 1004)	NC score	0.050592 (rank : 1109)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 1005)	NC score	0.052101 (rank : 1053)
Query Neighborhood Hits	495	Target Neighborhood Hits	844	Shared Neighborhood Hits	85
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PTK6_HUMAN
θ value	θ > 10 (rank : 1006)	NC score	0.111443 (rank : 531)
Query Neighborhood Hits	495	Target Neighborhood Hits	1020	Shared Neighborhood Hits	87
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 1007)	NC score	0.113923 (rank : 508)
Query Neighborhood Hits	495	Target Neighborhood Hits	1026	Shared Neighborhood Hits	87
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 1008)	NC score	0.078491 (rank : 659)
Query Neighborhood Hits	495	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 1009)	NC score	0.078484 (rank : 660)
Query Neighborhood Hits	495	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 1010)	NC score	0.085120 (rank : 621)
Query Neighborhood Hits	495	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 1011)	NC score	0.084715 (rank : 625)
Query Neighborhood Hits	495	Target Neighborhood Hits	123	Shared Neighborhood Hits	20
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN13_HUMAN
θ value	θ > 10 (rank : 1012)	NC score	0.060563 (rank : 790)
Query Neighborhood Hits	495	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
θ value	θ > 10 (rank : 1013)	NC score	0.061337 (rank : 777)
Query Neighborhood Hits	495	Target Neighborhood Hits	426	Shared Neighborhood Hits	23
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN14_HUMAN
θ value	θ > 10 (rank : 1014)	NC score	0.069213 (rank : 692)
Query Neighborhood Hits	495	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN14_MOUSE
θ value	θ > 10 (rank : 1015)	NC score	0.068701 (rank : 698)
Query Neighborhood Hits	495	Target Neighborhood Hits	142	Shared Neighborhood Hits	20
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN18_HUMAN
θ value	θ > 10 (rank : 1016)	NC score	0.085617 (rank : 619)
Query Neighborhood Hits	495	Target Neighborhood Hits	73	Shared Neighborhood Hits	18
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 1017)	NC score	0.086340 (rank : 616)
Query Neighborhood Hits	495	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 1018)	NC score	0.087318 (rank : 608)
Query Neighborhood Hits	495	Target Neighborhood Hits	84	Shared Neighborhood Hits	19
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 1019)	NC score	0.087263 (rank : 609)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN21_HUMAN
θ value	θ > 10 (rank : 1020)	NC score	0.067907 (rank : 704)
Query Neighborhood Hits	495	Target Neighborhood Hits	143	Shared Neighborhood Hits	18
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN21_MOUSE
θ value	θ > 10 (rank : 1021)	NC score	0.068719 (rank : 697)
Query Neighborhood Hits	495	Target Neighborhood Hits	155	Shared Neighborhood Hits	21
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN22_HUMAN
θ value	θ > 10 (rank : 1022)	NC score	0.086833 (rank : 612)
Query Neighborhood Hits	495	Target Neighborhood Hits	109	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 1023)	NC score	0.084366 (rank : 627)
Query Neighborhood Hits	495	Target Neighborhood Hits	179	Shared Neighborhood Hits	21
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 1024)	NC score	0.070436 (rank : 688)
Query Neighborhood Hits	495	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 1025)	NC score	0.072769 (rank : 679)
Query Neighborhood Hits	495	Target Neighborhood Hits	726	Shared Neighborhood Hits	34
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 1026)	NC score	0.088713 (rank : 595)
Query Neighborhood Hits	495	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 1027)	NC score	0.088076 (rank : 601)
Query Neighborhood Hits	495	Target Neighborhood Hits	107	Shared Neighborhood Hits	19
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN3_HUMAN
θ value	θ > 10 (rank : 1028)	NC score	0.066671 (rank : 708)
Query Neighborhood Hits	495	Target Neighborhood Hits	258	Shared Neighborhood Hits	26
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN4_HUMAN
θ value	θ > 10 (rank : 1029)	NC score	0.064475 (rank : 736)
Query Neighborhood Hits	495	Target Neighborhood Hits	303	Shared Neighborhood Hits	25
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN5_HUMAN
θ value	θ > 10 (rank : 1030)	NC score	0.089606 (rank : 588)
Query Neighborhood Hits	495	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 1031)	NC score	0.089573 (rank : 590)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 1032)	NC score	0.080841 (rank : 640)
Query Neighborhood Hits	495	Target Neighborhood Hits	234	Shared Neighborhood Hits	22
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 1033)	NC score	0.080684 (rank : 643)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 1034)	NC score	0.089889 (rank : 585)
Query Neighborhood Hits	495	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 1035)	NC score	0.089882 (rank : 586)
Query Neighborhood Hits	495	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 1036)	NC score	0.089902 (rank : 584)
Query Neighborhood Hits	495	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 1037)	NC score	0.090210 (rank : 580)
Query Neighborhood Hits	495	Target Neighborhood Hits	78	Shared Neighborhood Hits	18
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 1038)	NC score	0.087574 (rank : 606)
Query Neighborhood Hits	495	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 1039)	NC score	0.087753 (rank : 602)
Query Neighborhood Hits	495	Target Neighborhood Hits	120	Shared Neighborhood Hits	19
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 1040)	NC score	0.113187 (rank : 517)
Query Neighborhood Hits	495	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 1041)	NC score	0.112636 (rank : 522)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	19
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRE_HUMAN
θ value	θ > 10 (rank : 1042)	NC score	0.113021 (rank : 518)
Query Neighborhood Hits	495	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 1043)	NC score	0.113280 (rank : 514)
Query Neighborhood Hits	495	Target Neighborhood Hits	86	Shared Neighborhood Hits	19
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRG_HUMAN
θ value	θ > 10 (rank : 1044)	NC score	0.118780 (rank : 483)
Query Neighborhood Hits	495	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	θ > 10 (rank : 1045)	NC score	0.117459 (rank : 488)
Query Neighborhood Hits	495	Target Neighborhood Hits	260	Shared Neighborhood Hits	56
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRN_HUMAN
θ value	θ > 10 (rank : 1046)	NC score	0.087530 (rank : 607)
Query Neighborhood Hits	495	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 1047)	NC score	0.088168 (rank : 599)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	26
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 1048)	NC score	0.087594 (rank : 605)
Query Neighborhood Hits	495	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 1049)	NC score	0.087602 (rank : 604)
Query Neighborhood Hits	495	Target Neighborhood Hits	84	Shared Neighborhood Hits	19
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PVRL2_MOUSE
θ value	θ > 10 (rank : 1050)	NC score	0.253504 (rank : 321)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	134
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

R4RL1_HUMAN
θ value	θ > 10 (rank : 1051)	NC score	0.061834 (rank : 767)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

R4RL1_MOUSE
θ value	θ > 10 (rank : 1052)	NC score	0.059214 (rank : 827)
Query Neighborhood Hits	495	Target Neighborhood Hits	235	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K0S5	Gene names	Rtn4rl1, Ngrl2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

R4RL2_HUMAN
θ value	θ > 10 (rank : 1053)	NC score	0.063927 (rank : 742)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

R4RL2_MOUSE
θ value	θ > 10 (rank : 1054)	NC score	0.063897 (rank : 743)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

RAF1_HUMAN
θ value	θ > 10 (rank : 1055)	NC score	0.091877 (rank : 573)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	86
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 1056)	NC score	0.092604 (rank : 568)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	87
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RET_HUMAN
θ value	θ > 10 (rank : 1057)	NC score	0.136960 (rank : 438)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 1058)	NC score	0.137807 (rank : 434)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	87
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIPK1_HUMAN
θ value	θ > 10 (rank : 1059)	NC score	0.086846 (rank : 611)
Query Neighborhood Hits	495	Target Neighborhood Hits	891	Shared Neighborhood Hits	86
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 1060)	NC score	0.087692 (rank : 603)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	86
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 1061)	NC score	0.083498 (rank : 631)
Query Neighborhood Hits	495	Target Neighborhood Hits	774	Shared Neighborhood Hits	83
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 1062)	NC score	0.086448 (rank : 615)
Query Neighborhood Hits	495	Target Neighborhood Hits	776	Shared Neighborhood Hits	84
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 1063)	NC score	0.086570 (rank : 614)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 1064)	NC score	0.068645 (rank : 699)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 1065)	NC score	0.063148 (rank : 750)
Query Neighborhood Hits	495	Target Neighborhood Hits	1094	Shared Neighborhood Hits	87
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 1066)	NC score	0.078808 (rank : 657)
Query Neighborhood Hits	495	Target Neighborhood Hits	864	Shared Neighborhood Hits	85
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 1067)	NC score	0.078761 (rank : 658)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 1068)	NC score	0.125992 (rank : 460)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	84
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 1069)	NC score	0.127993 (rank : 450)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	84
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RTN4R_HUMAN
θ value	θ > 10 (rank : 1070)	NC score	0.062958 (rank : 754)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

RTN4R_MOUSE
θ value	θ > 10 (rank : 1071)	NC score	0.059739 (rank : 813)
Query Neighborhood Hits	495	Target Neighborhood Hits	293	Shared Neighborhood Hits	45
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

RXFP2_HUMAN
θ value	θ > 10 (rank : 1072)	NC score	0.050941 (rank : 1097)
Query Neighborhood Hits	495	Target Neighborhood Hits	736	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

RXFP2_MOUSE
θ value	θ > 10 (rank : 1073)	NC score	0.051879 (rank : 1059)
Query Neighborhood Hits	495	Target Neighborhood Hits	760	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

RYK_HUMAN
θ value	θ > 10 (rank : 1074)	NC score	0.150114 (rank : 415)
Query Neighborhood Hits	495	Target Neighborhood Hits	701	Shared Neighborhood Hits	83
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 1075)	NC score	0.148219 (rank : 416)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	82
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1076)	NC score	0.051604 (rank : 1074)
Query Neighborhood Hits	495	Target Neighborhood Hits	603	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SIGL9_HUMAN
θ value	θ > 10 (rank : 1077)	NC score	0.113871 (rank : 509)
Query Neighborhood Hits	495	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

SLAF5_MOUSE
θ value	θ > 10 (rank : 1078)	NC score	0.052408 (rank : 1045)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	51
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

SLAF9_MOUSE
θ value	θ > 10 (rank : 1079)	NC score	0.055923 (rank : 908)
Query Neighborhood Hits	495	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D780, Q8BTK0, Q8VE93	Gene names	Slamf9
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor.

SLIT1_HUMAN
θ value	θ > 10 (rank : 1080)	NC score	0.070619 (rank : 687)
Query Neighborhood Hits	495	Target Neighborhood Hits	700	Shared Neighborhood Hits	67
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SLIT1_MOUSE
θ value	θ > 10 (rank : 1081)	NC score	0.072959 (rank : 678)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	68
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

SLIT2_HUMAN
θ value	θ > 10 (rank : 1082)	NC score	0.075126 (rank : 667)
Query Neighborhood Hits	495	Target Neighborhood Hits	708	Shared Neighborhood Hits	69
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	θ > 10 (rank : 1083)	NC score	0.073860 (rank : 673)
Query Neighborhood Hits	495	Target Neighborhood Hits	684	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT3_HUMAN
θ value	θ > 10 (rank : 1084)	NC score	0.071281 (rank : 683)
Query Neighborhood Hits	495	Target Neighborhood Hits	682	Shared Neighborhood Hits	67
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

SLIT3_MOUSE
θ value	θ > 10 (rank : 1085)	NC score	0.071029 (rank : 686)
Query Neighborhood Hits	495	Target Neighborhood Hits	700	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SLK_HUMAN
θ value	θ > 10 (rank : 1086)	NC score	0.057016 (rank : 886)
Query Neighborhood Hits	495	Target Neighborhood Hits	1775	Shared Neighborhood Hits	95
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 1087)	NC score	0.056469 (rank : 901)
Query Neighborhood Hits	495	Target Neighborhood Hits	1798	Shared Neighborhood Hits	93
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SN1L1_HUMAN
θ value	θ > 10 (rank : 1088)	NC score	0.055421 (rank : 929)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	88
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 1089)	NC score	0.056510 (rank : 899)
Query Neighborhood Hits	495	Target Neighborhood Hits	895	Shared Neighborhood Hits	86
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 1090)	NC score	0.057319 (rank : 877)
Query Neighborhood Hits	495	Target Neighborhood Hits	964	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 1091)	NC score	0.056996 (rank : 887)
Query Neighborhood Hits	495	Target Neighborhood Hits	944	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SRC_HUMAN
θ value	θ > 10 (rank : 1092)	NC score	0.111796 (rank : 529)
Query Neighborhood Hits	495	Target Neighborhood Hits	1058	Shared Neighborhood Hits	91
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 1093)	NC score	0.112234 (rank : 526)
Query Neighborhood Hits	495	Target Neighborhood Hits	1033	Shared Neighborhood Hits	89
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SREC2_HUMAN
θ value	θ > 10 (rank : 1094)	NC score	0.061651 (rank : 769)
Query Neighborhood Hits	495	Target Neighborhood Hits	645	Shared Neighborhood Hits	48
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SREC2_MOUSE
θ value	θ > 10 (rank : 1095)	NC score	0.057710 (rank : 865)
Query Neighborhood Hits	495	Target Neighborhood Hits	605	Shared Neighborhood Hits	41
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC_HUMAN
θ value	θ > 10 (rank : 1096)	NC score	0.059131 (rank : 829)
Query Neighborhood Hits	495	Target Neighborhood Hits	645	Shared Neighborhood Hits	43
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

SRMS_HUMAN
θ value	θ > 10 (rank : 1097)	NC score	0.120908 (rank : 478)
Query Neighborhood Hits	495	Target Neighborhood Hits	946	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 1098)	NC score	0.119425 (rank : 481)
Query Neighborhood Hits	495	Target Neighborhood Hits	964	Shared Neighborhood Hits	86
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SSPO_MOUSE
θ value	θ > 10 (rank : 1099)	NC score	0.052480 (rank : 1042)
Query Neighborhood Hits	495	Target Neighborhood Hits	800	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ST17A_HUMAN
θ value	θ > 10 (rank : 1100)	NC score	0.058189 (rank : 851)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 1101)	NC score	0.057411 (rank : 876)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	81
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 1102)	NC score	0.061201 (rank : 779)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK10_HUMAN
θ value	θ > 10 (rank : 1103)	NC score	0.053255 (rank : 1018)
Query Neighborhood Hits	495	Target Neighborhood Hits	1921	Shared Neighborhood Hits	93
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 1104)	NC score	0.055157 (rank : 945)
Query Neighborhood Hits	495	Target Neighborhood Hits	831	Shared Neighborhood Hits	84
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK16_HUMAN
θ value	θ > 10 (rank : 1105)	NC score	0.060431 (rank : 794)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 1106)	NC score	0.060176 (rank : 804)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 1107)	NC score	0.068907 (rank : 696)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 1108)	NC score	0.069044 (rank : 693)
Query Neighborhood Hits	495	Target Neighborhood Hits	856	Shared Neighborhood Hits	85
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 1109)	NC score	0.064906 (rank : 728)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 1110)	NC score	0.065197 (rank : 724)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 1111)	NC score	0.062369 (rank : 760)
Query Neighborhood Hits	495	Target Neighborhood Hits	879	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK36_HUMAN
θ value	θ > 10 (rank : 1112)	NC score	0.061130 (rank : 780)
Query Neighborhood Hits	495	Target Neighborhood Hits	896	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 1113)	NC score	0.062424 (rank : 758)
Query Neighborhood Hits	495	Target Neighborhood Hits	877	Shared Neighborhood Hits	85
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK39_HUMAN
θ value	θ > 10 (rank : 1114)	NC score	0.060240 (rank : 800)
Query Neighborhood Hits	495	Target Neighborhood Hits	882	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 1115)	NC score	0.060525 (rank : 792)
Query Neighborhood Hits	495	Target Neighborhood Hits	915	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 1116)	NC score	0.063122 (rank : 751)
Query Neighborhood Hits	495	Target Neighborhood Hits	861	Shared Neighborhood Hits	85
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 1117)	NC score	0.063819 (rank : 746)
Query Neighborhood Hits	495	Target Neighborhood Hits	869	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 1118)	NC score	0.063894 (rank : 744)
Query Neighborhood Hits	495	Target Neighborhood Hits	870	Shared Neighborhood Hits	85
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 1119)	NC score	0.064117 (rank : 738)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 1120)	NC score	0.056583 (rank : 897)
Query Neighborhood Hits	495	Target Neighborhood Hits	916	Shared Neighborhood Hits	87
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 1121)	NC score	0.055603 (rank : 920)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	86
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STYK1_HUMAN
θ value	θ > 10 (rank : 1122)	NC score	0.137753 (rank : 435)
Query Neighborhood Hits	495	Target Neighborhood Hits	786	Shared Neighborhood Hits	87
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 1123)	NC score	0.140646 (rank : 430)
Query Neighborhood Hits	495	Target Neighborhood Hits	779	Shared Neighborhood Hits	86
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAOK2_HUMAN
θ value	θ > 10 (rank : 1124)	NC score	0.054899 (rank : 955)
Query Neighborhood Hits	495	Target Neighborhood Hits	1172	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 1125)	NC score	0.052886 (rank : 1030)
Query Neighborhood Hits	495	Target Neighborhood Hits	1373	Shared Neighborhood Hits	90
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TBK1_HUMAN
θ value	θ > 10 (rank : 1126)	NC score	0.050554 (rank : 1110)
Query Neighborhood Hits	495	Target Neighborhood Hits	861	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 1127)	NC score	0.050134 (rank : 1120)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	82
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TEC_HUMAN
θ value	θ > 10 (rank : 1128)	NC score	0.113648 (rank : 512)
Query Neighborhood Hits	495	Target Neighborhood Hits	1006	Shared Neighborhood Hits	86
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 1129)	NC score	0.113255 (rank : 515)
Query Neighborhood Hits	495	Target Neighborhood Hits	1006	Shared Neighborhood Hits	87
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 1130)	NC score	0.084801 (rank : 624)
Query Neighborhood Hits	495	Target Neighborhood Hits	864	Shared Neighborhood Hits	85
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 1131)	NC score	0.085643 (rank : 617)
Query Neighborhood Hits	495	Target Neighborhood Hits	862	Shared Neighborhood Hits	86
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 1132)	NC score	0.090214 (rank : 579)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 1133)	NC score	0.090110 (rank : 581)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 1134)	NC score	0.081393 (rank : 638)
Query Neighborhood Hits	495	Target Neighborhood Hits	1103	Shared Neighborhood Hits	92
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1135)	NC score	0.080318 (rank : 647)
Query Neighborhood Hits	495	Target Neighborhood Hits	1333	Shared Neighborhood Hits	92
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 1136)	NC score	0.066183 (rank : 717)
Query Neighborhood Hits	495	Target Neighborhood Hits	755	Shared Neighborhood Hits	84
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 1137)	NC score	0.066545 (rank : 710)
Query Neighborhood Hits	495	Target Neighborhood Hits	753	Shared Neighborhood Hits	84
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 1138)	NC score	0.071854 (rank : 681)
Query Neighborhood Hits	495	Target Neighborhood Hits	748	Shared Neighborhood Hits	83
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 1139)	NC score	0.071073 (rank : 685)
Query Neighborhood Hits	495	Target Neighborhood Hits	748	Shared Neighborhood Hits	84
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TIMD1_HUMAN
θ value	θ > 10 (rank : 1140)	NC score	0.053537 (rank : 1006)
Query Neighborhood Hits	495	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

TLR13_MOUSE
θ value	θ > 10 (rank : 1141)	NC score	0.055130 (rank : 948)
Query Neighborhood Hits	495	Target Neighborhood Hits	335	Shared Neighborhood Hits	53
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

TLR3_HUMAN
θ value	θ > 10 (rank : 1142)	NC score	0.053142 (rank : 1025)
Query Neighborhood Hits	495	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

TLR3_MOUSE
θ value	θ > 10 (rank : 1143)	NC score	0.053806 (rank : 995)
Query Neighborhood Hits	495	Target Neighborhood Hits	298	Shared Neighborhood Hits	46
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

TLR5_HUMAN
θ value	θ > 10 (rank : 1144)	NC score	0.055250 (rank : 941)
Query Neighborhood Hits	495	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

TLR5_MOUSE
θ value	θ > 10 (rank : 1145)	NC score	0.052613 (rank : 1038)
Query Neighborhood Hits	495	Target Neighborhood Hits	287	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

TLR9_HUMAN
θ value	θ > 10 (rank : 1146)	NC score	0.050021 (rank : 1122)
Query Neighborhood Hits	495	Target Neighborhood Hits	295	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NR96, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3	Gene names	TLR9
Domain Architecture
Description	Toll-like receptor 9 precursor (CD289 antigen).

TMM25_HUMAN
θ value	θ > 10 (rank : 1147)	NC score	0.071266 (rank : 684)
Query Neighborhood Hits	495	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TNI3K_HUMAN
θ value	θ > 10 (rank : 1148)	NC score	0.075135 (rank : 666)
Query Neighborhood Hits	495	Target Neighborhood Hits	1084	Shared Neighborhood Hits	85
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 1149)	NC score	0.076002 (rank : 663)
Query Neighborhood Hits	495	Target Neighborhood Hits	1079	Shared Neighborhood Hits	86
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 1150)	NC score	0.053834 (rank : 994)
Query Neighborhood Hits	495	Target Neighborhood Hits	1570	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TNK1_HUMAN
θ value	θ > 10 (rank : 1151)	NC score	0.130330 (rank : 447)
Query Neighborhood Hits	495	Target Neighborhood Hits	815	Shared Neighborhood Hits	86
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 1152)	NC score	0.128186 (rank : 449)
Query Neighborhood Hits	495	Target Neighborhood Hits	806	Shared Neighborhood Hits	90
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 1153)	NC score	0.080705 (rank : 642)
Query Neighborhood Hits	495	Target Neighborhood Hits	605	Shared Neighborhood Hits	76
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 1154)	NC score	0.081912 (rank : 637)
Query Neighborhood Hits	495	Target Neighborhood Hits	618	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TPBG_HUMAN
θ value	θ > 10 (rank : 1155)	NC score	0.061245 (rank : 778)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	44
SwissProt Accessions	Q13641	Gene names	TPBG, 5T4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (5T4 oncofetal antigen) (M6P1).

TPBG_MOUSE
θ value	θ > 10 (rank : 1156)	NC score	0.058664 (rank : 836)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z0L0, Q6PE98, Q8BQA4	Gene names	Tpbg, 5t4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein).

TSK_HUMAN
θ value	θ > 10 (rank : 1157)	NC score	0.063954 (rank : 739)
Query Neighborhood Hits	495	Target Neighborhood Hits	268	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

TSK_MOUSE
θ value	θ > 10 (rank : 1158)	NC score	0.057122 (rank : 882)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

TSSK1_MOUSE
θ value	θ > 10 (rank : 1159)	NC score	0.052405 (rank : 1046)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	83
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 1160)	NC score	0.050886 (rank : 1099)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK4_MOUSE
θ value	θ > 10 (rank : 1161)	NC score	0.051197 (rank : 1086)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 1162)	NC score	0.053187 (rank : 1022)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 1163)	NC score	0.053237 (rank : 1019)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	85
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TXK_HUMAN
θ value	θ > 10 (rank : 1164)	NC score	0.114384 (rank : 500)
Query Neighborhood Hits	495	Target Neighborhood Hits	971	Shared Neighborhood Hits	86
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 1165)	NC score	0.115488 (rank : 492)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	86
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 1166)	NC score	0.107403 (rank : 543)
Query Neighborhood Hits	495	Target Neighborhood Hits	841	Shared Neighborhood Hits	85
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 1167)	NC score	0.108527 (rank : 539)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

UHMK1_HUMAN
θ value	θ > 10 (rank : 1168)	NC score	0.056374 (rank : 903)
Query Neighborhood Hits	495	Target Neighborhood Hits	808	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	θ > 10 (rank : 1169)	NC score	0.056987 (rank : 888)
Query Neighborhood Hits	495	Target Neighborhood Hits	809	Shared Neighborhood Hits	77
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK1_HUMAN
θ value	θ > 10 (rank : 1170)	NC score	0.060592 (rank : 789)
Query Neighborhood Hits	495	Target Neighborhood Hits	1121	Shared Neighborhood Hits	92
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 1171)	NC score	0.060340 (rank : 797)
Query Neighborhood Hits	495	Target Neighborhood Hits	1214	Shared Neighborhood Hits	96
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 1172)	NC score	0.060500 (rank : 793)
Query Neighborhood Hits	495	Target Neighborhood Hits	979	Shared Neighborhood Hits	90
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 1173)	NC score	0.060351 (rank : 796)
Query Neighborhood Hits	495	Target Neighborhood Hits	943	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 1174)	NC score	0.060724 (rank : 788)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	85
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 1175)	NC score	0.061084 (rank : 782)
Query Neighborhood Hits	495	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

WEE1_MOUSE
θ value	θ > 10 (rank : 1176)	NC score	0.050175 (rank : 1118)
Query Neighborhood Hits	495	Target Neighborhood Hits	794	Shared Neighborhood Hits	75
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

WIF1_HUMAN
θ value	θ > 10 (rank : 1177)	NC score	0.053420 (rank : 1014)
Query Neighborhood Hits	495	Target Neighborhood Hits	392	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

WIF1_MOUSE
θ value	θ > 10 (rank : 1178)	NC score	0.052678 (rank : 1036)
Query Neighborhood Hits	495	Target Neighborhood Hits	393	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

YES_HUMAN
θ value	θ > 10 (rank : 1179)	NC score	0.112367 (rank : 525)
Query Neighborhood Hits	495	Target Neighborhood Hits	1059	Shared Neighborhood Hits	92
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 1180)	NC score	0.112431 (rank : 523)
Query Neighborhood Hits	495	Target Neighborhood Hits	1052	Shared Neighborhood Hits	93
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YSK4_HUMAN
θ value	θ > 10 (rank : 1181)	NC score	0.066533 (rank : 713)
Query Neighborhood Hits	495	Target Neighborhood Hits	921	Shared Neighborhood Hits	88
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 1182)	NC score	0.122581 (rank : 475)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	86
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 1183)	NC score	0.123739 (rank : 470)
Query Neighborhood Hits	495	Target Neighborhood Hits	905	Shared Neighborhood Hits	86
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

SDK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	495	Target Neighborhood Hits	495	Shared Neighborhood Hits	495
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
NC score	0.996449 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	495	Target Neighborhood Hits	480	Shared Neighborhood Hits	447
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK1_MOUSE
NC score	0.986379 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	495	Target Neighborhood Hits	495	Shared Neighborhood Hits	410
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_HUMAN
NC score	0.985948 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	495	Target Neighborhood Hits	511	Shared Neighborhood Hits	410
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

DSCL1_HUMAN
NC score	0.936214 (rank : 5)	θ value	3.33315e-87 (rank : 6)
Query Neighborhood Hits	495	Target Neighborhood Hits	589	Shared Neighborhood Hits	410
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DSCAM_HUMAN
NC score	0.934649 (rank : 6)	θ value	8.20983e-86 (rank : 7)
Query Neighborhood Hits	495	Target Neighborhood Hits	524	Shared Neighborhood Hits	397
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

NEO1_HUMAN
NC score	0.927547 (rank : 7)	θ value	2.03627e-60 (rank : 32)
Query Neighborhood Hits	495	Target Neighborhood Hits	530	Shared Neighborhood Hits	395
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
NC score	0.924526 (rank : 8)	θ value	6.77864e-56 (rank : 34)
Query Neighborhood Hits	495	Target Neighborhood Hits	523	Shared Neighborhood Hits	390
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

DCC_HUMAN
NC score	0.924106 (rank : 9)	θ value	5.17823e-64 (rank : 26)
Query Neighborhood Hits	495	Target Neighborhood Hits	583	Shared Neighborhood Hits	404
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

NRCAM_HUMAN
NC score	0.923692 (rank : 10)	θ value	3.96481e-64 (rank : 25)
Query Neighborhood Hits	495	Target Neighborhood Hits	439	Shared Neighborhood Hits	379
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
NC score	0.922394 (rank : 11)	θ value	7.71989e-68 (rank : 20)
Query Neighborhood Hits	495	Target Neighborhood Hits	432	Shared Neighborhood Hits	367
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

CNTN2_HUMAN
NC score	0.918440 (rank : 12)	θ value	2.73936e-73 (rank : 15)
Query Neighborhood Hits	495	Target Neighborhood Hits	440	Shared Neighborhood Hits	386
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN3_HUMAN
NC score	0.918064 (rank : 13)	θ value	1.14559e-87 (rank : 5)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	390
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

L1CAM_HUMAN
NC score	0.917942 (rank : 14)	θ value	2.84138e-62 (rank : 28)
Query Neighborhood Hits	495	Target Neighborhood Hits	457	Shared Neighborhood Hits	382
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NFASC_HUMAN
NC score	0.917888 (rank : 15)	θ value	9.76566e-63 (rank : 27)
Query Neighborhood Hits	495	Target Neighborhood Hits	497	Shared Neighborhood Hits	383
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

L1CAM_MOUSE
NC score	0.916684 (rank : 16)	θ value	3.96481e-64 (rank : 24)
Query Neighborhood Hits	495	Target Neighborhood Hits	457	Shared Neighborhood Hits	382
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN2_MOUSE
NC score	0.916481 (rank : 17)	θ value	1.27248e-70 (rank : 16)
Query Neighborhood Hits	495	Target Neighborhood Hits	450	Shared Neighborhood Hits	380
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN3_MOUSE
NC score	0.913300 (rank : 18)	θ value	5.50685e-82 (rank : 8)
Query Neighborhood Hits	495	Target Neighborhood Hits	447	Shared Neighborhood Hits	387
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN5_HUMAN
NC score	0.911839 (rank : 19)	θ value	2.17053e-70 (rank : 17)
Query Neighborhood Hits	495	Target Neighborhood Hits	446	Shared Neighborhood Hits	383
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CHL1_HUMAN
NC score	0.911064 (rank : 20)	θ value	3.4653e-68 (rank : 19)
Query Neighborhood Hits	495	Target Neighborhood Hits	413	Shared Neighborhood Hits	365
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CNTN5_MOUSE
NC score	0.908160 (rank : 21)	θ value	1.00825e-67 (rank : 21)
Query Neighborhood Hits	495	Target Neighborhood Hits	434	Shared Neighborhood Hits	372
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

NFASC_MOUSE
NC score	0.907386 (rank : 22)	θ value	2.49495e-50 (rank : 39)
Query Neighborhood Hits	495	Target Neighborhood Hits	475	Shared Neighborhood Hits	376
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

DCC_MOUSE
NC score	0.905583 (rank : 23)	θ value	1.04338e-64 (rank : 23)
Query Neighborhood Hits	495	Target Neighborhood Hits	896	Shared Neighborhood Hits	406
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

CNTN4_MOUSE
NC score	0.905538 (rank : 24)	θ value	4.82422e-78 (rank : 12)
Query Neighborhood Hits	495	Target Neighborhood Hits	445	Shared Neighborhood Hits	371
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_HUMAN
NC score	0.905449 (rank : 25)	θ value	8.79181e-80 (rank : 10)
Query Neighborhood Hits	495	Target Neighborhood Hits	449	Shared Neighborhood Hits	369
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN1_MOUSE
NC score	0.904960 (rank : 26)	θ value	2.40537e-61 (rank : 30)
Query Neighborhood Hits	495	Target Neighborhood Hits	422	Shared Neighborhood Hits	367
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN1_HUMAN
NC score	0.904450 (rank : 27)	θ value	8.26713e-62 (rank : 29)
Query Neighborhood Hits	495	Target Neighborhood Hits	431	Shared Neighborhood Hits	366
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN6_HUMAN
NC score	0.902420 (rank : 28)	θ value	1.77149e-80 (rank : 9)
Query Neighborhood Hits	495	Target Neighborhood Hits	422	Shared Neighborhood Hits	362
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CHL1_MOUSE
NC score	0.902045 (rank : 29)	θ value	1.90147e-66 (rank : 22)
Query Neighborhood Hits	495	Target Neighborhood Hits	402	Shared Neighborhood Hits	357
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CNTN6_MOUSE
NC score	0.901134 (rank : 30)	θ value	1.26953e-78 (rank : 11)
Query Neighborhood Hits	495	Target Neighborhood Hits	429	Shared Neighborhood Hits	370
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

ROBO2_HUMAN
NC score	0.896053 (rank : 31)	θ value	1.0458e-56 (rank : 33)
Query Neighborhood Hits	495	Target Neighborhood Hits	479	Shared Neighborhood Hits	393
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

PUNC_HUMAN
NC score	0.894928 (rank : 32)	θ value	1.51715e-39 (rank : 45)
Query Neighborhood Hits	495	Target Neighborhood Hits	449	Shared Neighborhood Hits	346
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ROBO2_MOUSE
NC score	0.894557 (rank : 33)	θ value	4.85792e-54 (rank : 36)
Query Neighborhood Hits	495	Target Neighborhood Hits	504	Shared Neighborhood Hits	401
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_HUMAN
NC score	0.892459 (rank : 34)	θ value	2.41096e-53 (rank : 37)
Query Neighborhood Hits	495	Target Neighborhood Hits	570	Shared Neighborhood Hits	386
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

PUNC_MOUSE
NC score	0.888286 (rank : 35)	θ value	2.58786e-39 (rank : 46)
Query Neighborhood Hits	495	Target Neighborhood Hits	501	Shared Neighborhood Hits	339
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ROBO3_MOUSE
NC score	0.887743 (rank : 36)	θ value	1.97686e-47 (rank : 43)
Query Neighborhood Hits	495	Target Neighborhood Hits	524	Shared Neighborhood Hits	377
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

ROBO1_MOUSE
NC score	0.885223 (rank : 37)	θ value	7.25919e-50 (rank : 40)
Query Neighborhood Hits	495	Target Neighborhood Hits	559	Shared Neighborhood Hits	391
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO1_HUMAN
NC score	0.881043 (rank : 38)	θ value	3.1488e-53 (rank : 38)
Query Neighborhood Hits	495	Target Neighborhood Hits	529	Shared Neighborhood Hits	383
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

CDON_HUMAN
NC score	0.867661 (rank : 39)	θ value	1.9192e-34 (rank : 52)
Query Neighborhood Hits	495	Target Neighborhood Hits	412	Shared Neighborhood Hits	339
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_MOUSE
NC score	0.867241 (rank : 40)	θ value	1.01765e-35 (rank : 49)
Query Neighborhood Hits	495	Target Neighborhood Hits	410	Shared Neighborhood Hits	341
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

BOC_HUMAN
NC score	0.859718 (rank : 41)	θ value	8.06329e-33 (rank : 57)
Query Neighborhood Hits	495	Target Neighborhood Hits	543	Shared Neighborhood Hits	356
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BOC_MOUSE
NC score	0.857668 (rank : 42)	θ value	9.52487e-34 (rank : 53)
Query Neighborhood Hits	495	Target Neighborhood Hits	433	Shared Neighborhood Hits	344
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCAM2_MOUSE
NC score	0.855590 (rank : 43)	θ value	1.16434e-31 (rank : 58)
Query Neighborhood Hits	495	Target Neighborhood Hits	472	Shared Neighborhood Hits	384
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCAM2_HUMAN
NC score	0.846089 (rank : 44)	θ value	6.61148e-27 (rank : 64)
Query Neighborhood Hits	495	Target Neighborhood Hits	441	Shared Neighborhood Hits	375
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCA11_HUMAN
NC score	0.826428 (rank : 45)	θ value	4.72714e-33 (rank : 56)
Query Neighborhood Hits	495	Target Neighborhood Hits	443	Shared Neighborhood Hits	361
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA12_MOUSE
NC score	0.819943 (rank : 46)	θ value	6.59618e-35 (rank : 50)
Query Neighborhood Hits	495	Target Neighborhood Hits	399	Shared Neighborhood Hits	338
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCA12_HUMAN
NC score	0.818254 (rank : 47)	θ value	3.3877e-31 (rank : 59)
Query Neighborhood Hits	495	Target Neighborhood Hits	437	Shared Neighborhood Hits	356
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA11_MOUSE
NC score	0.809517 (rank : 48)	θ value	8.61488e-35 (rank : 51)
Query Neighborhood Hits	495	Target Neighborhood Hits	661	Shared Neighborhood Hits	357
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

ROBO4_MOUSE
NC score	0.792608 (rank : 49)	θ value	2.06002e-20 (rank : 76)
Query Neighborhood Hits	495	Target Neighborhood Hits	358	Shared Neighborhood Hits	272
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MYOM2_HUMAN
NC score	0.791097 (rank : 50)	θ value	8.3442e-30 (rank : 60)
Query Neighborhood Hits	495	Target Neighborhood Hits	341	Shared Neighborhood Hits	305
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

OBSL1_HUMAN
NC score	0.789427 (rank : 51)	θ value	9.56915e-18 (rank : 85)
Query Neighborhood Hits	495	Target Neighborhood Hits	354	Shared Neighborhood Hits	287
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

ROBO4_HUMAN
NC score	0.788909 (rank : 52)	θ value	2.5182e-18 (rank : 81)
Query Neighborhood Hits	495	Target Neighborhood Hits	364	Shared Neighborhood Hits	273
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

MYOM1_HUMAN
NC score	0.785569 (rank : 53)	θ value	3.50572e-28 (rank : 61)
Query Neighborhood Hits	495	Target Neighborhood Hits	405	Shared Neighborhood Hits	312
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

FGRL1_HUMAN
NC score	0.778290 (rank : 54)	θ value	5.60996e-18 (rank : 84)
Query Neighborhood Hits	495	Target Neighborhood Hits	335	Shared Neighborhood Hits	282
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

MYOTI_HUMAN
NC score	0.775714 (rank : 55)	θ value	1.99529e-15 (rank : 101)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	264
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
NC score	0.774019 (rank : 56)	θ value	5.8054e-15 (rank : 108)
Query Neighborhood Hits	495	Target Neighborhood Hits	297	Shared Neighborhood Hits	262
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYOM1_MOUSE
NC score	0.773718 (rank : 57)	θ value	1.29031e-22 (rank : 71)
Query Neighborhood Hits	495	Target Neighborhood Hits	415	Shared Neighborhood Hits	329
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

FGRL1_MOUSE
NC score	0.771980 (rank : 58)	θ value	3.40345e-15 (rank : 105)
Query Neighborhood Hits	495	Target Neighborhood Hits	325	Shared Neighborhood Hits	287
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

MYPN_HUMAN
NC score	0.770604 (rank : 59)	θ value	2.13179e-17 (rank : 87)
Query Neighborhood Hits	495	Target Neighborhood Hits	418	Shared Neighborhood Hits	285
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

NPHN_HUMAN
NC score	0.767560 (rank : 60)	θ value	4.02038e-16 (rank : 97)
Query Neighborhood Hits	495	Target Neighborhood Hits	362	Shared Neighborhood Hits	305
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

MYPN_MOUSE
NC score	0.761001 (rank : 61)	θ value	2.35696e-16 (rank : 95)
Query Neighborhood Hits	495	Target Neighborhood Hits	421	Shared Neighborhood Hits	281
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

MAMC1_HUMAN
NC score	0.753681 (rank : 62)	θ value	5.25075e-16 (rank : 98)
Query Neighborhood Hits	495	Target Neighborhood Hits	357	Shared Neighborhood Hits	293
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
NC score	0.751813 (rank : 63)	θ value	2.60593e-15 (rank : 103)
Query Neighborhood Hits	495	Target Neighborhood Hits	357	Shared Neighborhood Hits	293
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

NPHN_MOUSE
NC score	0.750737 (rank : 64)	θ value	2.60593e-15 (rank : 104)
Query Neighborhood Hits	495	Target Neighborhood Hits	370	Shared Neighborhood Hits	303
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

PTPRD_MOUSE
NC score	0.744063 (rank : 65)	θ value	1.19377e-60 (rank : 31)
Query Neighborhood Hits	495	Target Neighborhood Hits	491	Shared Neighborhood Hits	373
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

MDGA1_HUMAN
NC score	0.743771 (rank : 66)	θ value	8.10077e-17 (rank : 91)
Query Neighborhood Hits	495	Target Neighborhood Hits	358	Shared Neighborhood Hits	294
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

LSAMP_MOUSE
NC score	0.741448 (rank : 67)	θ value	6.00763e-12 (rank : 128)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	298
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

PTPRF_HUMAN
NC score	0.740302 (rank : 68)	θ value	4.99229e-75 (rank : 13)
Query Neighborhood Hits	495	Target Neighborhood Hits	489	Shared Neighborhood Hits	370
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

LSAMP_HUMAN
NC score	0.739415 (rank : 69)	θ value	2.52405e-10 (rank : 148)
Query Neighborhood Hits	495	Target Neighborhood Hits	347	Shared Neighborhood Hits	300
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

NEGR1_HUMAN
NC score	0.733859 (rank : 70)	θ value	1.29331e-14 (rank : 111)
Query Neighborhood Hits	495	Target Neighborhood Hits	346	Shared Neighborhood Hits	289
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

PTPRD_HUMAN
NC score	0.733094 (rank : 71)	θ value	5.51964e-74 (rank : 14)
Query Neighborhood Hits	495	Target Neighborhood Hits	485	Shared Neighborhood Hits	365
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

NEGR1_MOUSE
NC score	0.731757 (rank : 72)	θ value	8.38298e-14 (rank : 115)
Query Neighborhood Hits	495	Target Neighborhood Hits	349	Shared Neighborhood Hits	292
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

FNDC3_MOUSE
NC score	0.727533 (rank : 73)	θ value	5.97985e-28 (rank : 62)
Query Neighborhood Hits	495	Target Neighborhood Hits	207	Shared Neighborhood Hits	176
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_HUMAN
NC score	0.727079 (rank : 74)	θ value	3.62785e-25 (rank : 67)
Query Neighborhood Hits	495	Target Neighborhood Hits	196	Shared Neighborhood Hits	173
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

OPCM_HUMAN
NC score	0.726450 (rank : 75)	θ value	1.33837e-11 (rank : 131)
Query Neighborhood Hits	495	Target Neighborhood Hits	332	Shared Neighborhood Hits	291
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

PTPRS_HUMAN
NC score	0.723001 (rank : 76)	θ value	9.11921e-69 (rank : 18)
Query Neighborhood Hits	495	Target Neighborhood Hits	472	Shared Neighborhood Hits	359
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

NTRI_MOUSE
NC score	0.720542 (rank : 77)	θ value	5.26297e-08 (rank : 182)
Query Neighborhood Hits	495	Target Neighborhood Hits	342	Shared Neighborhood Hits	295
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

NTRI_HUMAN
NC score	0.715841 (rank : 78)	θ value	2.21117e-06 (rank : 212)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	294
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

MYPC2_MOUSE
NC score	0.701712 (rank : 79)	θ value	4.29542e-18 (rank : 83)
Query Neighborhood Hits	495	Target Neighborhood Hits	297	Shared Neighborhood Hits	270
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC2_HUMAN
NC score	0.700551 (rank : 80)	θ value	4.29542e-18 (rank : 82)
Query Neighborhood Hits	495	Target Neighborhood Hits	316	Shared Neighborhood Hits	284
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

VCAM1_MOUSE
NC score	0.694735 (rank : 81)	θ value	1.17247e-07 (rank : 188)
Query Neighborhood Hits	495	Target Neighborhood Hits	320	Shared Neighborhood Hits	271
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

MYPC1_HUMAN
NC score	0.692817 (rank : 82)	θ value	5.25075e-16 (rank : 99)
Query Neighborhood Hits	495	Target Neighborhood Hits	303	Shared Neighborhood Hits	277
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

VCAM1_HUMAN
NC score	0.690232 (rank : 83)	θ value	1.69304e-06 (rank : 211)
Query Neighborhood Hits	495	Target Neighborhood Hits	352	Shared Neighborhood Hits	269
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

MYPC3_HUMAN
NC score	0.680437 (rank : 84)	θ value	1.42992e-13 (rank : 116)
Query Neighborhood Hits	495	Target Neighborhood Hits	318	Shared Neighborhood Hits	282
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MAG_MOUSE
NC score	0.679959 (rank : 85)	θ value	6.00763e-12 (rank : 129)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	252
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_HUMAN
NC score	0.676804 (rank : 86)	θ value	3.08544e-08 (rank : 179)
Query Neighborhood Hits	495	Target Neighborhood Hits	278	Shared Neighborhood Hits	254
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

KIRR2_HUMAN
NC score	0.675989 (rank : 87)	θ value	2.28291e-11 (rank : 135)
Query Neighborhood Hits	495	Target Neighborhood Hits	321	Shared Neighborhood Hits	249
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

SN_MOUSE
NC score	0.675686 (rank : 88)	θ value	1.99529e-15 (rank : 102)
Query Neighborhood Hits	495	Target Neighborhood Hits	416	Shared Neighborhood Hits	298
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

MYPC3_MOUSE
NC score	0.675455 (rank : 89)	θ value	2.20605e-14 (rank : 113)
Query Neighborhood Hits	495	Target Neighborhood Hits	310	Shared Neighborhood Hits	279
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

KIRR2_MOUSE
NC score	0.669025 (rank : 90)	θ value	1.38499e-08 (rank : 170)
Query Neighborhood Hits	495	Target Neighborhood Hits	326	Shared Neighborhood Hits	253
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

SN_HUMAN
NC score	0.663838 (rank : 91)	θ value	1.2105e-12 (rank : 120)
Query Neighborhood Hits	495	Target Neighborhood Hits	434	Shared Neighborhood Hits	298
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

LU_HUMAN
NC score	0.658445 (rank : 92)	θ value	3.19293e-05 (rank : 240)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	249
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

FSTL5_HUMAN
NC score	0.655255 (rank : 93)	θ value	1.63604e-09 (rank : 156)
Query Neighborhood Hits	495	Target Neighborhood Hits	347	Shared Neighborhood Hits	263
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL4_HUMAN
NC score	0.653453 (rank : 94)	θ value	4.76016e-09 (rank : 160)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	265
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

CD22_MOUSE
NC score	0.652965 (rank : 95)	θ value	2.79066e-09 (rank : 158)
Query Neighborhood Hits	495	Target Neighborhood Hits	331	Shared Neighborhood Hits	252
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

FSTL4_MOUSE
NC score	0.647515 (rank : 96)	θ value	1.25267e-09 (rank : 155)
Query Neighborhood Hits	495	Target Neighborhood Hits	333	Shared Neighborhood Hits	260
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FSTL5_MOUSE
NC score	0.646989 (rank : 97)	θ value	1.80886e-08 (rank : 174)
Query Neighborhood Hits	495	Target Neighborhood Hits	355	Shared Neighborhood Hits	258
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

MALT1_HUMAN
NC score	0.643825 (rank : 98)	θ value	0.0252991 (rank : 346)
Query Neighborhood Hits	495	Target Neighborhood Hits	236	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

TMIGD_HUMAN
NC score	0.642356 (rank : 99)	θ value	2.44474e-05 (rank : 237)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	220
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

CD22_HUMAN
NC score	0.641216 (rank : 100)	θ value	8.97725e-08 (rank : 184)
Query Neighborhood Hits	495	Target Neighborhood Hits	365	Shared Neighborhood Hits	264
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

ICAM5_MOUSE
NC score	0.638072 (rank : 101)	θ value	6.00763e-12 (rank : 127)
Query Neighborhood Hits	495	Target Neighborhood Hits	308	Shared Neighborhood Hits	247
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

JAM1_HUMAN
NC score	0.633619 (rank : 102)	θ value	1.43324e-05 (rank : 227)
Query Neighborhood Hits	495	Target Neighborhood Hits	294	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

RAGE_HUMAN
NC score	0.632806 (rank : 103)	θ value	0.00175202 (rank : 308)
Query Neighborhood Hits	495	Target Neighborhood Hits	269	Shared Neighborhood Hits	244
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

KIRR1_HUMAN
NC score	0.630012 (rank : 104)	θ value	1.38178e-16 (rank : 94)
Query Neighborhood Hits	495	Target Neighborhood Hits	401	Shared Neighborhood Hits	253
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

MUC18_HUMAN
NC score	0.629330 (rank : 105)	θ value	0.00020696 (rank : 263)
Query Neighborhood Hits	495	Target Neighborhood Hits	275	Shared Neighborhood Hits	230
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

KIRR3_HUMAN
NC score	0.628545 (rank : 106)	θ value	1.47974e-10 (rank : 143)
Query Neighborhood Hits	495	Target Neighborhood Hits	302	Shared Neighborhood Hits	244
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

KIRR1_MOUSE
NC score	0.624749 (rank : 107)	θ value	3.40345e-15 (rank : 106)
Query Neighborhood Hits	495	Target Neighborhood Hits	403	Shared Neighborhood Hits	252
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KIRR3_MOUSE
NC score	0.621499 (rank : 108)	θ value	4.30538e-10 (rank : 152)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	237
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

JAM3_MOUSE
NC score	0.617183 (rank : 109)	θ value	9.92553e-07 (rank : 198)
Query Neighborhood Hits	495	Target Neighborhood Hits	286	Shared Neighborhood Hits	239
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

JAM3_HUMAN
NC score	0.616050 (rank : 110)	θ value	1.09739e-05 (rank : 224)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	237
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

ICAM5_HUMAN
NC score	0.615601 (rank : 111)	θ value	5.26297e-08 (rank : 181)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	242
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

TMIGD_MOUSE
NC score	0.615570 (rank : 112)	θ value	5.44631e-05 (rank : 249)
Query Neighborhood Hits	495	Target Neighborhood Hits	234	Shared Neighborhood Hits	221
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

MUC18_MOUSE
NC score	0.613371 (rank : 113)	θ value	0.000602161 (rank : 281)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	230
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

PGBM_HUMAN
NC score	0.612972 (rank : 114)	θ value	3.61944e-33 (rank : 54)
Query Neighborhood Hits	495	Target Neighborhood Hits	1113	Shared Neighborhood Hits	363
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

JAM1_MOUSE
NC score	0.611796 (rank : 115)	θ value	1.87187e-05 (rank : 229)
Query Neighborhood Hits	495	Target Neighborhood Hits	287	Shared Neighborhood Hits	240
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

CEAM5_HUMAN
NC score	0.609400 (rank : 116)	θ value	3.89403e-11 (rank : 139)
Query Neighborhood Hits	495	Target Neighborhood Hits	343	Shared Neighborhood Hits	275
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

FINC_MOUSE
NC score	0.605706 (rank : 117)	θ value	3.4976e-36 (rank : 48)
Query Neighborhood Hits	495	Target Neighborhood Hits	309	Shared Neighborhood Hits	181
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

HMCN1_HUMAN
NC score	0.605399 (rank : 118)	θ value	8.87376e-48 (rank : 42)
Query Neighborhood Hits	495	Target Neighborhood Hits	983	Shared Neighborhood Hits	357
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

NPTN_HUMAN
NC score	0.600509 (rank : 119)	θ value	0.00175202 (rank : 306)
Query Neighborhood Hits	495	Target Neighborhood Hits	212	Shared Neighborhood Hits	200
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

RAGE_MOUSE
NC score	0.600266 (rank : 120)	θ value	0.0431538 (rank : 360)
Query Neighborhood Hits	495	Target Neighborhood Hits	295	Shared Neighborhood Hits	226
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

MYBPH_MOUSE
NC score	0.599081 (rank : 121)	θ value	2.44474e-05 (rank : 235)
Query Neighborhood Hits	495	Target Neighborhood Hits	290	Shared Neighborhood Hits	237
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

FINC_HUMAN
NC score	0.598411 (rank : 122)	θ value	4.72714e-33 (rank : 55)
Query Neighborhood Hits	495	Target Neighborhood Hits	302	Shared Neighborhood Hits	190
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

PGBM_MOUSE
NC score	0.598218 (rank : 123)	θ value	2.96777e-27 (rank : 63)
Query Neighborhood Hits	495	Target Neighborhood Hits	1073	Shared Neighborhood Hits	357
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CEAM1_MOUSE
NC score	0.595148 (rank : 124)	θ value	6.64225e-11 (rank : 140)
Query Neighborhood Hits	495	Target Neighborhood Hits	326	Shared Neighborhood Hits	262
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

JAM2_HUMAN
NC score	0.593867 (rank : 125)	θ value	1.09739e-05 (rank : 223)
Query Neighborhood Hits	495	Target Neighborhood Hits	304	Shared Neighborhood Hits	267
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

NPTN_MOUSE
NC score	0.593282 (rank : 126)	θ value	0.000270298 (rank : 270)
Query Neighborhood Hits	495	Target Neighborhood Hits	216	Shared Neighborhood Hits	200
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

MYBPH_HUMAN
NC score	0.587832 (rank : 127)	θ value	0.000786445 (rank : 284)
Query Neighborhood Hits	495	Target Neighborhood Hits	256	Shared Neighborhood Hits	231
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

LRIG1_HUMAN
NC score	0.585925 (rank : 128)	θ value	8.10077e-17 (rank : 90)
Query Neighborhood Hits	495	Target Neighborhood Hits	654	Shared Neighborhood Hits	313
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

LRIG2_HUMAN
NC score	0.582885 (rank : 129)	θ value	1.13037e-18 (rank : 80)
Query Neighborhood Hits	495	Target Neighborhood Hits	595	Shared Neighborhood Hits	306
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

LRIG2_MOUSE
NC score	0.580695 (rank : 130)	θ value	7.82807e-20 (rank : 77)
Query Neighborhood Hits	495	Target Neighborhood Hits	586	Shared Neighborhood Hits	306
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

LRIG1_MOUSE
NC score	0.575248 (rank : 131)	θ value	1.24977e-17 (rank : 86)
Query Neighborhood Hits	495	Target Neighborhood Hits	627	Shared Neighborhood Hits	308
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

IGS4B_MOUSE
NC score	0.574296 (rank : 132)	θ value	0.00134147 (rank : 293)
Query Neighborhood Hits	495	Target Neighborhood Hits	328	Shared Neighborhood Hits	257
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

VSIG2_HUMAN
NC score	0.570409 (rank : 133)	θ value	0.000158464 (rank : 259)
Query Neighborhood Hits	495	Target Neighborhood Hits	321	Shared Neighborhood Hits	244
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

JAM2_MOUSE
NC score	0.568891 (rank : 134)	θ value	0.00298849 (rank : 315)
Query Neighborhood Hits	495	Target Neighborhood Hits	292	Shared Neighborhood Hits	254
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

FCRL5_HUMAN
NC score	0.568645 (rank : 135)	θ value	0.000270298 (rank : 267)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	222
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

IGS4B_HUMAN
NC score	0.564146 (rank : 136)	θ value	0.00175202 (rank : 303)
Query Neighborhood Hits	495	Target Neighborhood Hits	305	Shared Neighborhood Hits	245
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

CEA20_HUMAN
NC score	0.561655 (rank : 137)	θ value	0.000602161 (rank : 278)
Query Neighborhood Hits	495	Target Neighborhood Hits	251	Shared Neighborhood Hits	206
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

LRIG3_MOUSE
NC score	0.561445 (rank : 138)	θ value	1.058e-16 (rank : 92)
Query Neighborhood Hits	495	Target Neighborhood Hits	611	Shared Neighborhood Hits	310
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

CI094_HUMAN
NC score	0.560522 (rank : 139)	θ value	1.06045e-08 (rank : 166)
Query Neighborhood Hits	495	Target Neighborhood Hits	310	Shared Neighborhood Hits	230
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

BASI_HUMAN
NC score	0.558003 (rank : 140)	θ value	1.69304e-06 (rank : 205)
Query Neighborhood Hits	495	Target Neighborhood Hits	211	Shared Neighborhood Hits	194
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

KAZD1_MOUSE
NC score	0.557193 (rank : 141)	θ value	0.000158464 (rank : 256)
Query Neighborhood Hits	495	Target Neighborhood Hits	281	Shared Neighborhood Hits	203
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

TITIN_HUMAN
NC score	0.557133 (rank : 142)	θ value	6.77864e-56 (rank : 35)
Query Neighborhood Hits	495	Target Neighborhood Hits	2923	Shared Neighborhood Hits	456
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

VSIG2_MOUSE
NC score	0.556958 (rank : 143)	θ value	0.00020696 (rank : 265)
Query Neighborhood Hits	495	Target Neighborhood Hits	316	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

SIG11_HUMAN
NC score	0.555586 (rank : 144)	θ value	1.09739e-05 (rank : 225)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	244
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

LRIG3_HUMAN
NC score	0.554990 (rank : 145)	θ value	6.85773e-16 (rank : 100)
Query Neighborhood Hits	495	Target Neighborhood Hits	601	Shared Neighborhood Hits	307
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

SIG10_HUMAN
NC score	0.548739 (rank : 146)	θ value	7.59969e-07 (rank : 197)
Query Neighborhood Hits	495	Target Neighborhood Hits	363	Shared Neighborhood Hits	237
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

CEAM1_HUMAN
NC score	0.543516 (rank : 147)	θ value	2.79066e-09 (rank : 159)
Query Neighborhood Hits	495	Target Neighborhood Hits	348	Shared Neighborhood Hits	256
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

BASI_MOUSE
NC score	0.542946 (rank : 148)	θ value	0.00035302 (rank : 274)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	208
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

FCRL2_HUMAN
NC score	0.541780 (rank : 149)	θ value	0.00134147 (rank : 292)
Query Neighborhood Hits	495	Target Neighborhood Hits	251	Shared Neighborhood Hits	205
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

MFA3L_HUMAN
NC score	0.521764 (rank : 150)	θ value	0.0563607 (rank : 364)
Query Neighborhood Hits	495	Target Neighborhood Hits	230	Shared Neighborhood Hits	210
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

KAZD1_HUMAN
NC score	0.518942 (rank : 151)	θ value	7.1131e-05 (rank : 250)
Query Neighborhood Hits	495	Target Neighborhood Hits	248	Shared Neighborhood Hits	168
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

CD166_MOUSE
NC score	0.514213 (rank : 152)	θ value	2.36244e-08 (rank : 175)
Query Neighborhood Hits	495	Target Neighborhood Hits	252	Shared Neighborhood Hits	205
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

IBP7_HUMAN
NC score	0.504948 (rank : 153)	θ value	4.45536e-07 (rank : 192)
Query Neighborhood Hits	495	Target Neighborhood Hits	220	Shared Neighborhood Hits	166
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

NRG2_HUMAN
NC score	0.500858 (rank : 154)	θ value	0.0736092 (rank : 369)
Query Neighborhood Hits	495	Target Neighborhood Hits	419	Shared Neighborhood Hits	239
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

PTK7_HUMAN
NC score	0.498645 (rank : 155)	θ value	7.04741e-37 (rank : 47)
Query Neighborhood Hits	495	Target Neighborhood Hits	1103	Shared Neighborhood Hits	345
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

NRG2_MOUSE
NC score	0.495979 (rank : 156)	θ value	0.0431538 (rank : 357)
Query Neighborhood Hits	495	Target Neighborhood Hits	392	Shared Neighborhood Hits	239
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

IL6RB_HUMAN
NC score	0.493457 (rank : 157)	θ value	7.09661e-13 (rank : 119)
Query Neighborhood Hits	495	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

IBP7_MOUSE
NC score	0.489091 (rank : 158)	θ value	1.29631e-06 (rank : 200)
Query Neighborhood Hits	495	Target Neighborhood Hits	230	Shared Neighborhood Hits	163
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

VSIG4_HUMAN
NC score	0.487564 (rank : 159)	θ value	0.0148317 (rank : 342)
Query Neighborhood Hits	495	Target Neighborhood Hits	236	Shared Neighborhood Hits	197
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

CD166_HUMAN
NC score	0.484307 (rank : 160)	θ value	3.08544e-08 (rank : 176)
Query Neighborhood Hits	495	Target Neighborhood Hits	247	Shared Neighborhood Hits	197
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

GPA33_MOUSE
NC score	0.482323 (rank : 161)	θ value	0.0148317 (rank : 339)
Query Neighborhood Hits	495	Target Neighborhood Hits	294	Shared Neighborhood Hits	204
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

CEAM6_HUMAN
NC score	0.476165 (rank : 162)	θ value	0.00102713 (rank : 285)
Query Neighborhood Hits	495	Target Neighborhood Hits	308	Shared Neighborhood Hits	254
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

COCA1_MOUSE
NC score	0.474135 (rank : 163)	θ value	3.62785e-25 (rank : 66)
Query Neighborhood Hits	495	Target Neighborhood Hits	467	Shared Neighborhood Hits	178
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

USH2A_HUMAN
NC score	0.468003 (rank : 164)	θ value	1.23823e-49 (rank : 41)
Query Neighborhood Hits	495	Target Neighborhood Hits	600	Shared Neighborhood Hits	185
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

GPA33_HUMAN
NC score	0.467479 (rank : 165)	θ value	0.00102713 (rank : 288)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	200
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

COCA1_HUMAN
NC score	0.458261 (rank : 166)	θ value	6.18819e-25 (rank : 69)
Query Neighborhood Hits	495	Target Neighborhood Hits	458	Shared Neighborhood Hits	169
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

MUSK_MOUSE
NC score	0.457192 (rank : 167)	θ value	4.73814e-25 (rank : 68)
Query Neighborhood Hits	495	Target Neighborhood Hits	1057	Shared Neighborhood Hits	330
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MUSK_HUMAN
NC score	0.456547 (rank : 168)	θ value	2.77775e-25 (rank : 65)
Query Neighborhood Hits	495	Target Neighborhood Hits	1074	Shared Neighborhood Hits	331
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

SIGL5_MOUSE
NC score	0.454289 (rank : 169)	θ value	0.000270298 (rank : 273)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	231
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

USH2A_MOUSE
NC score	0.451995 (rank : 170)	θ value	5.03882e-43 (rank : 44)
Query Neighborhood Hits	495	Target Neighborhood Hits	626	Shared Neighborhood Hits	179
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

ATL3_HUMAN
NC score	0.445032 (rank : 171)	θ value	2.98157e-11 (rank : 136)
Query Neighborhood Hits	495	Target Neighborhood Hits	414	Shared Neighborhood Hits	268
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

MFA3L_MOUSE
NC score	0.443069 (rank : 172)	θ value	1.38821 (rank : 424)
Query Neighborhood Hits	495	Target Neighborhood Hits	214	Shared Neighborhood Hits	192
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

IL6RB_MOUSE
NC score	0.441945 (rank : 173)	θ value	1.29631e-06 (rank : 201)
Query Neighborhood Hits	495	Target Neighborhood Hits	168	Shared Neighborhood Hits	135
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

I12R2_HUMAN
NC score	0.427218 (rank : 174)	θ value	2.52405e-10 (rank : 147)
Query Neighborhood Hits	495	Target Neighborhood Hits	163	Shared Neighborhood Hits	119
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

ITB4_HUMAN
NC score	0.427108 (rank : 175)	θ value	1.38178e-16 (rank : 93)
Query Neighborhood Hits	495	Target Neighborhood Hits	458	Shared Neighborhood Hits	160
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

LIFR_HUMAN
NC score	0.422135 (rank : 176)	θ value	8.40245e-06 (rank : 221)
Query Neighborhood Hits	495	Target Neighborhood Hits	130	Shared Neighborhood Hits	99
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

CEAM8_HUMAN
NC score	0.420947 (rank : 177)	θ value	0.0148317 (rank : 338)
Query Neighborhood Hits	495	Target Neighborhood Hits	264	Shared Neighborhood Hits	225
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

I12R2_MOUSE
NC score	0.420940 (rank : 178)	θ value	1.17247e-07 (rank : 187)
Query Neighborhood Hits	495	Target Neighborhood Hits	143	Shared Neighborhood Hits	120
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

PSG3_HUMAN
NC score	0.412034 (rank : 179)	θ value	5.44631e-05 (rank : 248)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	214
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

LIFR_MOUSE
NC score	0.411600 (rank : 180)	θ value	2.44474e-05 (rank : 234)
Query Neighborhood Hits	495	Target Neighborhood Hits	127	Shared Neighborhood Hits	99
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

VGFR1_HUMAN
NC score	0.409778 (rank : 181)	θ value	3.52202e-12 (rank : 124)
Query Neighborhood Hits	495	Target Neighborhood Hits	1109	Shared Neighborhood Hits	329
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

PSG8_HUMAN
NC score	0.406892 (rank : 182)	θ value	0.000158464 (rank : 257)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

VGFR1_MOUSE
NC score	0.405696 (rank : 183)	θ value	1.74796e-11 (rank : 133)
Query Neighborhood Hits	495	Target Neighborhood Hits	1118	Shared Neighborhood Hits	323
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

PSG4_HUMAN
NC score	0.405273 (rank : 184)	θ value	0.0431538 (rank : 359)
Query Neighborhood Hits	495	Target Neighborhood Hits	243	Shared Neighborhood Hits	211
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

COEA1_MOUSE
NC score	0.404392 (rank : 185)	θ value	6.20254e-17 (rank : 89)
Query Neighborhood Hits	495	Target Neighborhood Hits	402	Shared Neighborhood Hits	115
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

OBSCN_HUMAN
NC score	0.403845 (rank : 186)	θ value	1.02238e-19 (rank : 78)
Query Neighborhood Hits	495	Target Neighborhood Hits	1931	Shared Neighborhood Hits	387
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ESAM_HUMAN
NC score	0.401701 (rank : 187)	θ value	0.21417 (rank : 381)
Query Neighborhood Hits	495	Target Neighborhood Hits	251	Shared Neighborhood Hits	188
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

PSG11_HUMAN
NC score	0.396077 (rank : 188)	θ value	4.1701e-05 (rank : 243)
Query Neighborhood Hits	495	Target Neighborhood Hits	223	Shared Neighborhood Hits	204
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

LRFN4_HUMAN
NC score	0.395788 (rank : 189)	θ value	4.92598e-06 (rank : 216)
Query Neighborhood Hits	495	Target Neighborhood Hits	462	Shared Neighborhood Hits	228
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

PSG7_HUMAN
NC score	0.395440 (rank : 190)	θ value	0.00134147 (rank : 296)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	209
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

VGFR2_HUMAN
NC score	0.394183 (rank : 191)	θ value	2.13673e-09 (rank : 157)
Query Neighborhood Hits	495	Target Neighborhood Hits	1103	Shared Neighborhood Hits	328
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
NC score	0.391184 (rank : 192)	θ value	6.41864e-14 (rank : 114)
Query Neighborhood Hits	495	Target Neighborhood Hits	1089	Shared Neighborhood Hits	322
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

LRFN4_MOUSE
NC score	0.389270 (rank : 193)	θ value	4.1701e-05 (rank : 241)
Query Neighborhood Hits	495	Target Neighborhood Hits	442	Shared Neighborhood Hits	220
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

MYLK_HUMAN
NC score	0.388785 (rank : 194)	θ value	3.17815e-21 (rank : 75)
Query Neighborhood Hits	495	Target Neighborhood Hits	1328	Shared Neighborhood Hits	355
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PSG1_HUMAN
NC score	0.388011 (rank : 195)	θ value	0.000270298 (rank : 271)
Query Neighborhood Hits	495	Target Neighborhood Hits	232	Shared Neighborhood Hits	206
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PSG6_HUMAN
NC score	0.386975 (rank : 196)	θ value	0.00102713 (rank : 290)
Query Neighborhood Hits	495	Target Neighborhood Hits	231	Shared Neighborhood Hits	200
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

IL1R2_HUMAN
NC score	0.386137 (rank : 197)	θ value	5.44631e-05 (rank : 245)
Query Neighborhood Hits	495	Target Neighborhood Hits	153	Shared Neighborhood Hits	133
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

MYLK_MOUSE
NC score	0.385856 (rank : 198)	θ value	5.07402e-19 (rank : 79)
Query Neighborhood Hits	495	Target Neighborhood Hits	1489	Shared Neighborhood Hits	357
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

TENN_MOUSE
NC score	0.384845 (rank : 199)	θ value	1.86321e-21 (rank : 74)
Query Neighborhood Hits	495	Target Neighborhood Hits	484	Shared Neighborhood Hits	156
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

PSG10_HUMAN
NC score	0.383229 (rank : 200)	θ value	0.00175202 (rank : 307)
Query Neighborhood Hits	495	Target Neighborhood Hits	227	Shared Neighborhood Hits	199
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

CILP2_HUMAN
NC score	0.383221 (rank : 201)	θ value	4.92598e-06 (rank : 215)
Query Neighborhood Hits	495	Target Neighborhood Hits	307	Shared Neighborhood Hits	188
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

TENR_HUMAN
NC score	0.383083 (rank : 202)	θ value	2.87452e-22 (rank : 72)
Query Neighborhood Hits	495	Target Neighborhood Hits	526	Shared Neighborhood Hits	165
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

PSG2_HUMAN
NC score	0.383078 (rank : 203)	θ value	0.00035302 (rank : 276)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	203
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

LRFN2_MOUSE
NC score	0.382179 (rank : 204)	θ value	0.00020696 (rank : 262)
Query Neighborhood Hits	495	Target Neighborhood Hits	450	Shared Neighborhood Hits	229
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN2_HUMAN
NC score	0.381889 (rank : 205)	θ value	0.000270298 (rank : 269)
Query Neighborhood Hits	495	Target Neighborhood Hits	450	Shared Neighborhood Hits	223
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

CXAR_HUMAN
NC score	0.380664 (rank : 206)	θ value	0.00102713 (rank : 286)
Query Neighborhood Hits	495	Target Neighborhood Hits	245	Shared Neighborhood Hits	173
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

SPEG_MOUSE
NC score	0.378280 (rank : 207)	θ value	7.58209e-15 (rank : 110)
Query Neighborhood Hits	495	Target Neighborhood Hits	1959	Shared Neighborhood Hits	345
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

LRFN3_MOUSE
NC score	0.377944 (rank : 208)	θ value	7.1131e-05 (rank : 251)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	230
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

SPEG_HUMAN
NC score	0.374787 (rank : 209)	θ value	2.35696e-16 (rank : 96)
Query Neighborhood Hits	495	Target Neighborhood Hits	1762	Shared Neighborhood Hits	338
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CD276_HUMAN
NC score	0.373504 (rank : 210)	θ value	3.19293e-05 (rank : 238)
Query Neighborhood Hits	495	Target Neighborhood Hits	261	Shared Neighborhood Hits	168
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

TENR_MOUSE
NC score	0.372989 (rank : 211)	θ value	2.87452e-22 (rank : 73)
Query Neighborhood Hits	495	Target Neighborhood Hits	531	Shared Neighborhood Hits	161
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

PTPRM_HUMAN
NC score	0.370310 (rank : 212)	θ value	8.67504e-11 (rank : 141)
Query Neighborhood Hits	495	Target Neighborhood Hits	244	Shared Neighborhood Hits	163
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

SIGL5_HUMAN
NC score	0.369184 (rank : 213)	θ value	0.00509761 (rank : 324)
Query Neighborhood Hits	495	Target Neighborhood Hits	246	Shared Neighborhood Hits	195
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

PSG9_HUMAN
NC score	0.369143 (rank : 214)	θ value	0.000270298 (rank : 272)
Query Neighborhood Hits	495	Target Neighborhood Hits	221	Shared Neighborhood Hits	196
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

LRC21_MOUSE
NC score	0.369084 (rank : 215)	θ value	0.000270298 (rank : 268)
Query Neighborhood Hits	495	Target Neighborhood Hits	462	Shared Neighborhood Hits	245
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

CXAR_MOUSE
NC score	0.365991 (rank : 216)	θ value	0.00020696 (rank : 260)
Query Neighborhood Hits	495	Target Neighborhood Hits	250	Shared Neighborhood Hits	172
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

PTPRM_MOUSE
NC score	0.365313 (rank : 217)	θ value	4.30538e-10 (rank : 153)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	160
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

NRG1_HUMAN
NC score	0.364443 (rank : 218)	θ value	0.00298849 (rank : 316)
Query Neighborhood Hits	495	Target Neighborhood Hits	285	Shared Neighborhood Hits	169
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

CSF3R_HUMAN
NC score	0.363625 (rank : 219)	θ value	1.43324e-05 (rank : 226)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	110
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

FGFR4_MOUSE
NC score	0.361532 (rank : 220)	θ value	4.16044e-13 (rank : 118)
Query Neighborhood Hits	495	Target Neighborhood Hits	1026	Shared Neighborhood Hits	301
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

LRC21_HUMAN
NC score	0.361340 (rank : 221)	θ value	0.0113563 (rank : 334)
Query Neighborhood Hits	495	Target Neighborhood Hits	456	Shared Neighborhood Hits	242
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRFN5_MOUSE
NC score	0.361287 (rank : 222)	θ value	7.59969e-07 (rank : 196)
Query Neighborhood Hits	495	Target Neighborhood Hits	472	Shared Neighborhood Hits	231
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

SIGL8_HUMAN
NC score	0.360801 (rank : 223)	θ value	0.00228821 (rank : 313)
Query Neighborhood Hits	495	Target Neighborhood Hits	252	Shared Neighborhood Hits	219
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

PSG5_HUMAN
NC score	0.359918 (rank : 224)	θ value	0.0252991 (rank : 349)
Query Neighborhood Hits	495	Target Neighborhood Hits	231	Shared Neighborhood Hits	203
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

LRFN3_HUMAN
NC score	0.359023 (rank : 225)	θ value	0.00102713 (rank : 289)
Query Neighborhood Hits	495	Target Neighborhood Hits	444	Shared Neighborhood Hits	216
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

ESAM_MOUSE
NC score	0.358487 (rank : 226)	θ value	1.81305 (rank : 429)
Query Neighborhood Hits	495	Target Neighborhood Hits	222	Shared Neighborhood Hits	176
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

COEA1_HUMAN
NC score	0.358358 (rank : 227)	θ value	5.8054e-15 (rank : 107)
Query Neighborhood Hits	495	Target Neighborhood Hits	427	Shared Neighborhood Hits	128
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

TYRO3_HUMAN
NC score	0.355953 (rank : 228)	θ value	2.69671e-12 (rank : 121)
Query Neighborhood Hits	495	Target Neighborhood Hits	995	Shared Neighborhood Hits	283
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

FGFR4_HUMAN
NC score	0.355404 (rank : 229)	θ value	1.86753e-13 (rank : 117)
Query Neighborhood Hits	495	Target Neighborhood Hits	1037	Shared Neighborhood Hits	301
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

LRFN5_HUMAN
NC score	0.354099 (rank : 230)	θ value	1.69304e-06 (rank : 208)
Query Neighborhood Hits	495	Target Neighborhood Hits	464	Shared Neighborhood Hits	226
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

TYRO3_MOUSE
NC score	0.353012 (rank : 231)	θ value	3.52202e-12 (rank : 123)
Query Neighborhood Hits	495	Target Neighborhood Hits	1007	Shared Neighborhood Hits	290
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

FGFR3_MOUSE
NC score	0.351681 (rank : 232)	θ value	4.59992e-12 (rank : 125)
Query Neighborhood Hits	495	Target Neighborhood Hits	1059	Shared Neighborhood Hits	298
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR1_HUMAN
NC score	0.346283 (rank : 233)	θ value	1.9326e-10 (rank : 145)
Query Neighborhood Hits	495	Target Neighborhood Hits	1069	Shared Neighborhood Hits	299
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
NC score	0.345508 (rank : 234)	θ value	1.9326e-10 (rank : 146)
Query Neighborhood Hits	495	Target Neighborhood Hits	1068	Shared Neighborhood Hits	298
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR3_HUMAN
NC score	0.341072 (rank : 235)	θ value	1.133e-10 (rank : 142)
Query Neighborhood Hits	495	Target Neighborhood Hits	1042	Shared Neighborhood Hits	290
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

SIG12_HUMAN
NC score	0.339628 (rank : 236)	θ value	0.00665767 (rank : 328)
Query Neighborhood Hits	495	Target Neighborhood Hits	245	Shared Neighborhood Hits	220
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

PTPRT_MOUSE
NC score	0.339493 (rank : 237)	θ value	1.38499e-08 (rank : 173)
Query Neighborhood Hits	495	Target Neighborhood Hits	219	Shared Neighborhood Hits	139
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRT_HUMAN
NC score	0.338580 (rank : 238)	θ value	1.38499e-08 (rank : 172)
Query Neighborhood Hits	495	Target Neighborhood Hits	217	Shared Neighborhood Hits	138
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

UNC5D_MOUSE
NC score	0.337568 (rank : 239)	θ value	0.0252991 (rank : 352)
Query Neighborhood Hits	495	Target Neighborhood Hits	268	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

COKA1_HUMAN
NC score	0.337350 (rank : 240)	θ value	3.52202e-12 (rank : 122)
Query Neighborhood Hits	495	Target Neighborhood Hits	403	Shared Neighborhood Hits	119
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

FGFR2_HUMAN
NC score	0.337242 (rank : 241)	θ value	3.29651e-10 (rank : 149)
Query Neighborhood Hits	495	Target Neighborhood Hits	1062	Shared Neighborhood Hits	287
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

TENN_HUMAN
NC score	0.337193 (rank : 242)	θ value	4.76016e-09 (rank : 161)
Query Neighborhood Hits	495	Target Neighborhood Hits	453	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

VGFR3_MOUSE
NC score	0.336431 (rank : 243)	θ value	1.29631e-06 (rank : 204)
Query Neighborhood Hits	495	Target Neighborhood Hits	1056	Shared Neighborhood Hits	307
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_HUMAN
NC score	0.335193 (rank : 244)	θ value	3.77169e-06 (rank : 214)
Query Neighborhood Hits	495	Target Neighborhood Hits	1037	Shared Neighborhood Hits	296
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

CO7A1_HUMAN
NC score	0.334313 (rank : 245)	θ value	1.37858e-24 (rank : 70)
Query Neighborhood Hits	495	Target Neighborhood Hits	807	Shared Neighborhood Hits	168
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

LRRN1_HUMAN
NC score	0.334109 (rank : 246)	θ value	0.00390308 (rank : 319)
Query Neighborhood Hits	495	Target Neighborhood Hits	518	Shared Neighborhood Hits	259
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

HCFC2_MOUSE
NC score	0.334093 (rank : 247)	θ value	0.000602161 (rank : 279)
Query Neighborhood Hits	495	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

UNC5D_HUMAN
NC score	0.332113 (rank : 248)	θ value	0.0252991 (rank : 351)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	175
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

KALM_HUMAN
NC score	0.331678 (rank : 249)	θ value	0.00228821 (rank : 309)
Query Neighborhood Hits	495	Target Neighborhood Hits	114	Shared Neighborhood Hits	79
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

LRRN3_HUMAN
NC score	0.328742 (rank : 250)	θ value	5.44631e-05 (rank : 247)
Query Neighborhood Hits	495	Target Neighborhood Hits	461	Shared Neighborhood Hits	228
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

SIGL6_HUMAN
NC score	0.328657 (rank : 251)	θ value	1.38821 (rank : 427)
Query Neighborhood Hits	495	Target Neighborhood Hits	233	Shared Neighborhood Hits	205
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

FGFR2_MOUSE
NC score	0.327175 (rank : 252)	θ value	1.25267e-09 (rank : 154)
Query Neighborhood Hits	495	Target Neighborhood Hits	1062	Shared Neighborhood Hits	286
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

PVRL3_MOUSE
NC score	0.324788 (rank : 253)	θ value	0.21417 (rank : 385)
Query Neighborhood Hits	495	Target Neighborhood Hits	212	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

LRRN1_MOUSE
NC score	0.322585 (rank : 254)	θ value	0.00509761 (rank : 323)
Query Neighborhood Hits	495	Target Neighborhood Hits	508	Shared Neighborhood Hits	255
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

CILP1_MOUSE
NC score	0.321869 (rank : 255)	θ value	0.163984 (rank : 376)
Query Neighborhood Hits	495	Target Neighborhood Hits	282	Shared Neighborhood Hits	188
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

MERTK_HUMAN
NC score	0.321142 (rank : 256)	θ value	4.59992e-12 (rank : 126)
Query Neighborhood Hits	495	Target Neighborhood Hits	988	Shared Neighborhood Hits	270
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PTPRU_HUMAN
NC score	0.320772 (rank : 257)	θ value	5.26297e-08 (rank : 183)
Query Neighborhood Hits	495	Target Neighborhood Hits	237	Shared Neighborhood Hits	156
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

IRPL2_HUMAN
NC score	0.317845 (rank : 258)	θ value	0.00869519 (rank : 330)
Query Neighborhood Hits	495	Target Neighborhood Hits	194	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

PECA1_HUMAN
NC score	0.317802 (rank : 259)	θ value	0.0252991 (rank : 348)
Query Neighborhood Hits	495	Target Neighborhood Hits	178	Shared Neighborhood Hits	148
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

IL1R2_MOUSE
NC score	0.316441 (rank : 260)	θ value	0.0148317 (rank : 341)
Query Neighborhood Hits	495	Target Neighborhood Hits	125	Shared Neighborhood Hits	102
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

LRRN3_MOUSE
NC score	0.315158 (rank : 261)	θ value	4.1701e-05 (rank : 242)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	224
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

IRPL2_MOUSE
NC score	0.314486 (rank : 262)	θ value	0.00869519 (rank : 331)
Query Neighborhood Hits	495	Target Neighborhood Hits	195	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

MERTK_MOUSE
NC score	0.312982 (rank : 263)	θ value	2.98157e-11 (rank : 137)
Query Neighborhood Hits	495	Target Neighborhood Hits	974	Shared Neighborhood Hits	263
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PVRL3_HUMAN
NC score	0.310842 (rank : 264)	θ value	0.365318 (rank : 394)
Query Neighborhood Hits	495	Target Neighborhood Hits	204	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

LRRN5_HUMAN
NC score	0.309855 (rank : 265)	θ value	0.00228821 (rank : 312)
Query Neighborhood Hits	495	Target Neighborhood Hits	493	Shared Neighborhood Hits	244
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

IRPL1_MOUSE
NC score	0.309596 (rank : 266)	θ value	0.0113563 (rank : 333)
Query Neighborhood Hits	495	Target Neighborhood Hits	186	Shared Neighborhood Hits	154
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

UFO_MOUSE
NC score	0.305835 (rank : 267)	θ value	2.98157e-11 (rank : 138)
Query Neighborhood Hits	495	Target Neighborhood Hits	988	Shared Neighborhood Hits	260
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

CILP1_HUMAN
NC score	0.304073 (rank : 268)	θ value	0.125558 (rank : 373)
Query Neighborhood Hits	495	Target Neighborhood Hits	266	Shared Neighborhood Hits	169
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

PVRL1_HUMAN
NC score	0.303063 (rank : 269)	θ value	0.62314 (rank : 403)
Query Neighborhood Hits	495	Target Neighborhood Hits	219	Shared Neighborhood Hits	166
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

PTPRK_MOUSE
NC score	0.302625 (rank : 270)	θ value	4.45536e-07 (rank : 193)
Query Neighborhood Hits	495	Target Neighborhood Hits	223	Shared Neighborhood Hits	139
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

IRPL1_HUMAN
NC score	0.301907 (rank : 271)	θ value	0.0252991 (rank : 345)
Query Neighborhood Hits	495	Target Neighborhood Hits	196	Shared Neighborhood Hits	163
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

CSF3R_MOUSE
NC score	0.301674 (rank : 272)	θ value	1.87187e-05 (rank : 228)
Query Neighborhood Hits	495	Target Neighborhood Hits	104	Shared Neighborhood Hits	89
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSF1R_MOUSE
NC score	0.301669 (rank : 273)	θ value	0.47712 (rank : 396)
Query Neighborhood Hits	495	Target Neighborhood Hits	983	Shared Neighborhood Hits	248
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

UFO_HUMAN
NC score	0.298678 (rank : 274)	θ value	3.29651e-10 (rank : 151)
Query Neighborhood Hits	495	Target Neighborhood Hits	981	Shared Neighborhood Hits	256
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

PTPRK_HUMAN
NC score	0.298676 (rank : 275)	θ value	9.92553e-07 (rank : 199)
Query Neighborhood Hits	495	Target Neighborhood Hits	228	Shared Neighborhood Hits	142
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

ROR2_MOUSE
NC score	0.297573 (rank : 276)	θ value	1.87187e-05 (rank : 232)
Query Neighborhood Hits	495	Target Neighborhood Hits	1000	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

CD276_MOUSE
NC score	0.296684 (rank : 277)	θ value	0.813845 (rank : 408)
Query Neighborhood Hits	495	Target Neighborhood Hits	243	Shared Neighborhood Hits	173
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

PVRL1_MOUSE
NC score	0.295361 (rank : 278)	θ value	0.00134147 (rank : 297)
Query Neighborhood Hits	495	Target Neighborhood Hits	201	Shared Neighborhood Hits	157
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

TENA_HUMAN
NC score	0.292692 (rank : 279)	θ value	1.68911e-14 (rank : 112)
Query Neighborhood Hits	495	Target Neighborhood Hits	631	Shared Neighborhood Hits	158
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENX_HUMAN
NC score	0.290853 (rank : 280)	θ value	1.74796e-11 (rank : 132)
Query Neighborhood Hits	495	Target Neighborhood Hits	789	Shared Neighborhood Hits	165
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

PDL1_HUMAN
NC score	0.289795 (rank : 281)	θ value	θ > 10 (rank : 975)
Query Neighborhood Hits	495	Target Neighborhood Hits	195	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

ROR2_HUMAN
NC score	0.287706 (rank : 282)	θ value	1.87187e-05 (rank : 231)
Query Neighborhood Hits	495	Target Neighborhood Hits	1014	Shared Neighborhood Hits	260
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

NTRK2_HUMAN
NC score	0.287443 (rank : 283)	θ value	6.21693e-09 (rank : 163)
Query Neighborhood Hits	495	Target Neighborhood Hits	1081	Shared Neighborhood Hits	268
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.287318 (rank : 284)	θ value	1.38499e-08 (rank : 171)
Query Neighborhood Hits	495	Target Neighborhood Hits	1088	Shared Neighborhood Hits	267
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
NC score	0.286538 (rank : 285)	θ value	0.00390308 (rank : 320)
Query Neighborhood Hits	495	Target Neighborhood Hits	1115	Shared Neighborhood Hits	263
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

MOX2R_MOUSE
NC score	0.284449 (rank : 286)	θ value	0.0252991 (rank : 347)
Query Neighborhood Hits	495	Target Neighborhood Hits	110	Shared Neighborhood Hits	101
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

UNC5A_HUMAN
NC score	0.284090 (rank : 287)	θ value	0.00509761 (rank : 325)
Query Neighborhood Hits	495	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

LRC24_HUMAN
NC score	0.282776 (rank : 288)	θ value	5.44631e-05 (rank : 246)
Query Neighborhood Hits	495	Target Neighborhood Hits	404	Shared Neighborhood Hits	196
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

SORL_HUMAN
NC score	0.280856 (rank : 289)	θ value	4.74913e-17 (rank : 88)
Query Neighborhood Hits	495	Target Neighborhood Hits	440	Shared Neighborhood Hits	132
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

ROR1_HUMAN
NC score	0.279498 (rank : 290)	θ value	6.21693e-09 (rank : 164)
Query Neighborhood Hits	495	Target Neighborhood Hits	1018	Shared Neighborhood Hits	257
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

CEAM7_HUMAN
NC score	0.278187 (rank : 291)	θ value	0.0330416 (rank : 354)
Query Neighborhood Hits	495	Target Neighborhood Hits	170	Shared Neighborhood Hits	139
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

UNC5C_MOUSE
NC score	0.277908 (rank : 292)	θ value	0.00390308 (rank : 322)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	131
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.277403 (rank : 293)	θ value	0.00134147 (rank : 301)
Query Neighborhood Hits	495	Target Neighborhood Hits	226	Shared Neighborhood Hits	128
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

PIGR_MOUSE
NC score	0.277232 (rank : 294)	θ value	3.0926 (rank : 442)
Query Neighborhood Hits	495	Target Neighborhood Hits	214	Shared Neighborhood Hits	138
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

ROR1_MOUSE
NC score	0.277168 (rank : 295)	θ value	3.29651e-10 (rank : 150)
Query Neighborhood Hits	495	Target Neighborhood Hits	1025	Shared Neighborhood Hits	261
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

TENA_MOUSE
NC score	0.274878 (rank : 296)	θ value	1.29631e-06 (rank : 202)
Query Neighborhood Hits	495	Target Neighborhood Hits	596	Shared Neighborhood Hits	147
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

LRC4B_MOUSE
NC score	0.274634 (rank : 297)	θ value	8.97725e-08 (rank : 186)
Query Neighborhood Hits	495	Target Neighborhood Hits	484	Shared Neighborhood Hits	216
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

PGFRA_HUMAN
NC score	0.274147 (rank : 298)	θ value	0.00020696 (rank : 264)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	238
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

SORL_MOUSE
NC score	0.273206 (rank : 299)	θ value	7.58209e-15 (rank : 109)
Query Neighborhood Hits	495	Target Neighborhood Hits	439	Shared Neighborhood Hits	129
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

PGFRA_MOUSE
NC score	0.272636 (rank : 300)	θ value	0.00035302 (rank : 275)
Query Neighborhood Hits	495	Target Neighborhood Hits	975	Shared Neighborhood Hits	238
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRL_HUMAN
NC score	0.271950 (rank : 301)	θ value	1.38821 (rank : 426)
Query Neighborhood Hits	495	Target Neighborhood Hits	115	Shared Neighborhood Hits	113
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

LRC4B_HUMAN
NC score	0.271766 (rank : 302)	θ value	1.53129e-07 (rank : 189)
Query Neighborhood Hits	495	Target Neighborhood Hits	479	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

NGL1_MOUSE
NC score	0.271512 (rank : 303)	θ value	4.92598e-06 (rank : 218)
Query Neighborhood Hits	495	Target Neighborhood Hits	512	Shared Neighborhood Hits	223
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_HUMAN
NC score	0.271241 (rank : 304)	θ value	4.92598e-06 (rank : 217)
Query Neighborhood Hits	495	Target Neighborhood Hits	511	Shared Neighborhood Hits	223
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

DUET_HUMAN
NC score	0.270938 (rank : 305)	θ value	8.97725e-08 (rank : 185)
Query Neighborhood Hits	495	Target Neighborhood Hits	1220	Shared Neighborhood Hits	280
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

IGS21_HUMAN
NC score	0.269057 (rank : 306)	θ value	0.00175202 (rank : 302)
Query Neighborhood Hits	495	Target Neighborhood Hits	123	Shared Neighborhood Hits	105
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

TIE1_MOUSE
NC score	0.268776 (rank : 307)	θ value	5.81887e-07 (rank : 195)
Query Neighborhood Hits	495	Target Neighborhood Hits	1266	Shared Neighborhood Hits	232
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

PGFRB_MOUSE
NC score	0.268659 (rank : 308)	θ value	1.69304e-06 (rank : 210)
Query Neighborhood Hits	495	Target Neighborhood Hits	960	Shared Neighborhood Hits	226
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

UNC5B_HUMAN
NC score	0.267567 (rank : 309)	θ value	0.00134147 (rank : 300)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	131
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

KIT_MOUSE
NC score	0.264923 (rank : 310)	θ value	0.00134147 (rank : 295)
Query Neighborhood Hits	495	Target Neighborhood Hits	949	Shared Neighborhood Hits	221
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

IGS21_MOUSE
NC score	0.263845 (rank : 311)	θ value	0.0431538 (rank : 356)
Query Neighborhood Hits	495	Target Neighborhood Hits	118	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

UNC5B_MOUSE
NC score	0.263512 (rank : 312)	θ value	0.00298849 (rank : 317)
Query Neighborhood Hits	495	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

IL1R1_HUMAN
NC score	0.263164 (rank : 313)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	122
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

PVR_HUMAN
NC score	0.262611 (rank : 314)	θ value	0.62314 (rank : 404)
Query Neighborhood Hits	495	Target Neighborhood Hits	195	Shared Neighborhood Hits	133
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

TIE1_HUMAN
NC score	0.261528 (rank : 315)	θ value	8.11959e-09 (rank : 165)
Query Neighborhood Hits	495	Target Neighborhood Hits	1241	Shared Neighborhood Hits	219
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

ILRL2_MOUSE
NC score	0.259928 (rank : 316)	θ value	0.0252991 (rank : 344)
Query Neighborhood Hits	495	Target Neighborhood Hits	158	Shared Neighborhood Hits	141
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

EPHB6_HUMAN
NC score	0.259663 (rank : 317)	θ value	9.29e-05 (rank : 252)
Query Neighborhood Hits	495	Target Neighborhood Hits	912	Shared Neighborhood Hits	181
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

LRC24_MOUSE
NC score	0.259585 (rank : 318)	θ value	0.00228821 (rank : 311)
Query Neighborhood Hits	495	Target Neighborhood Hits	387	Shared Neighborhood Hits	193
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

PGFRB_HUMAN
NC score	0.257126 (rank : 319)	θ value	0.0113563 (rank : 335)
Query Neighborhood Hits	495	Target Neighborhood Hits	962	Shared Neighborhood Hits	232
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PIGR_HUMAN
NC score	0.257089 (rank : 320)	θ value	3.0926 (rank : 441)
Query Neighborhood Hits	495	Target Neighborhood Hits	164	Shared Neighborhood Hits	108
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PVRL2_MOUSE
NC score	0.253504 (rank : 321)	θ value	θ > 10 (rank : 1050)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	134
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

EPHB6_MOUSE
NC score	0.252755 (rank : 322)	θ value	0.000270298 (rank : 266)
Query Neighborhood Hits	495	Target Neighborhood Hits	906	Shared Neighborhood Hits	172
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

UNC5A_MOUSE
NC score	0.252344 (rank : 323)	θ value	0.00509761 (rank : 326)
Query Neighborhood Hits	495	Target Neighborhood Hits	203	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

PTPRB_HUMAN
NC score	0.252304 (rank : 324)	θ value	2.88788e-06 (rank : 213)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	109
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

KIT_HUMAN
NC score	0.252087 (rank : 325)	θ value	0.00228821 (rank : 310)
Query Neighborhood Hits	495	Target Neighborhood Hits	953	Shared Neighborhood Hits	215
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

EMB_MOUSE
NC score	0.250653 (rank : 326)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	495	Target Neighborhood Hits	83	Shared Neighborhood Hits	79
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

SIGL7_HUMAN
NC score	0.250607 (rank : 327)	θ value	0.279714 (rank : 389)
Query Neighborhood Hits	495	Target Neighborhood Hits	180	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

TIE2_MOUSE
NC score	0.250086 (rank : 328)	θ value	1.29631e-06 (rank : 203)
Query Neighborhood Hits	495	Target Neighborhood Hits	1204	Shared Neighborhood Hits	200
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

EPHA7_HUMAN
NC score	0.249513 (rank : 329)	θ value	1.33837e-11 (rank : 130)
Query Neighborhood Hits	495	Target Neighborhood Hits	1053	Shared Neighborhood Hits	192
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

CSF1R_HUMAN
NC score	0.249246 (rank : 330)	θ value	1.06291 (rank : 413)
Query Neighborhood Hits	495	Target Neighborhood Hits	943	Shared Neighborhood Hits	215
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHA8_MOUSE
NC score	0.248200 (rank : 331)	θ value	3.08544e-08 (rank : 178)
Query Neighborhood Hits	495	Target Neighborhood Hits	969	Shared Neighborhood Hits	189
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA7_MOUSE
NC score	0.247771 (rank : 332)	θ value	2.28291e-11 (rank : 134)
Query Neighborhood Hits	495	Target Neighborhood Hits	1025	Shared Neighborhood Hits	190
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

LRRC4_HUMAN
NC score	0.247309 (rank : 333)	θ value	1.69304e-06 (rank : 209)
Query Neighborhood Hits	495	Target Neighborhood Hits	444	Shared Neighborhood Hits	198
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

TIE2_HUMAN
NC score	0.246898 (rank : 334)	θ value	8.40245e-06 (rank : 222)
Query Neighborhood Hits	495	Target Neighborhood Hits	1192	Shared Neighborhood Hits	200
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

EPHB3_MOUSE
NC score	0.245474 (rank : 335)	θ value	1.69304e-06 (rank : 207)
Query Neighborhood Hits	495	Target Neighborhood Hits	996	Shared Neighborhood Hits	187
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHA8_HUMAN
NC score	0.245041 (rank : 336)	θ value	3.08544e-08 (rank : 177)
Query Neighborhood Hits	495	Target Neighborhood Hits	956	Shared Neighborhood Hits	187
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

IL1R1_MOUSE
NC score	0.244319 (rank : 337)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	495	Target Neighborhood Hits	142	Shared Neighborhood Hits	123
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

EPHA4_MOUSE
NC score	0.243611 (rank : 338)	θ value	6.21693e-09 (rank : 162)
Query Neighborhood Hits	495	Target Neighborhood Hits	982	Shared Neighborhood Hits	187
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHB3_HUMAN
NC score	0.243449 (rank : 339)	θ value	6.43352e-06 (rank : 219)
Query Neighborhood Hits	495	Target Neighborhood Hits	996	Shared Neighborhood Hits	186
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA3_MOUSE
NC score	0.242570 (rank : 340)	θ value	3.41135e-07 (rank : 191)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	192
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ROS_HUMAN
NC score	0.241216 (rank : 341)	θ value	6.43352e-06 (rank : 220)
Query Neighborhood Hits	495	Target Neighborhood Hits	907	Shared Neighborhood Hits	189
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

ILRL1_HUMAN
NC score	0.240843 (rank : 342)	θ value	0.47712 (rank : 397)
Query Neighborhood Hits	495	Target Neighborhood Hits	167	Shared Neighborhood Hits	127
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

EPHA4_HUMAN
NC score	0.240770 (rank : 343)	θ value	1.06045e-08 (rank : 167)
Query Neighborhood Hits	495	Target Neighborhood Hits	975	Shared Neighborhood Hits	184
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

PECA1_MOUSE
NC score	0.239856 (rank : 344)	θ value	1.81305 (rank : 432)
Query Neighborhood Hits	495	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

SIG12_MOUSE
NC score	0.238813 (rank : 345)	θ value	0.0431538 (rank : 362)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	167
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

EPHA3_HUMAN
NC score	0.237584 (rank : 346)	θ value	1.69304e-06 (rank : 206)
Query Neighborhood Hits	495	Target Neighborhood Hits	1005	Shared Neighborhood Hits	194
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

TARSH_HUMAN
NC score	0.237288 (rank : 347)	θ value	0.0736092 (rank : 370)
Query Neighborhood Hits	495	Target Neighborhood Hits	768	Shared Neighborhood Hits	120
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

PVRL2_HUMAN
NC score	0.236876 (rank : 348)	θ value	0.00134147 (rank : 298)
Query Neighborhood Hits	495	Target Neighborhood Hits	185	Shared Neighborhood Hits	131
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

EPHB4_MOUSE
NC score	0.235980 (rank : 349)	θ value	2.61198e-07 (rank : 190)
Query Neighborhood Hits	495	Target Neighborhood Hits	1013	Shared Neighborhood Hits	186
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

PGFRL_MOUSE
NC score	0.234518 (rank : 350)	θ value	0.365318 (rank : 392)
Query Neighborhood Hits	495	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

EPHA5_HUMAN
NC score	0.232728 (rank : 351)	θ value	1.9326e-10 (rank : 144)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	192
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PDL2_MOUSE
NC score	0.232277 (rank : 352)	θ value	0.365318 (rank : 391)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	96
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

EPHB4_HUMAN
NC score	0.229558 (rank : 353)	θ value	5.44631e-05 (rank : 244)
Query Neighborhood Hits	495	Target Neighborhood Hits	1056	Shared Neighborhood Hits	191
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

PDL1_MOUSE
NC score	0.227162 (rank : 354)	θ value	θ > 10 (rank : 976)
Query Neighborhood Hits	495	Target Neighborhood Hits	168	Shared Neighborhood Hits	121
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

HCFC2_HUMAN
NC score	0.226283 (rank : 355)	θ value	9.29e-05 (rank : 253)
Query Neighborhood Hits	495	Target Neighborhood Hits	154	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

EPHB2_MOUSE
NC score	0.225417 (rank : 356)	θ value	1.38499e-08 (rank : 169)
Query Neighborhood Hits	495	Target Neighborhood Hits	982	Shared Neighborhood Hits	175
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.225411 (rank : 357)	θ value	1.38499e-08 (rank : 168)
Query Neighborhood Hits	495	Target Neighborhood Hits	983	Shared Neighborhood Hits	175
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB1_HUMAN
NC score	0.224793 (rank : 358)	θ value	5.81887e-07 (rank : 194)
Query Neighborhood Hits	495	Target Neighborhood Hits	988	Shared Neighborhood Hits	179
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

CRLF1_HUMAN
NC score	0.223060 (rank : 359)	θ value	0.00298849 (rank : 314)
Query Neighborhood Hits	495	Target Neighborhood Hits	122	Shared Neighborhood Hits	92
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CT075_HUMAN
NC score	0.220641 (rank : 360)	θ value	0.000158464 (rank : 254)
Query Neighborhood Hits	495	Target Neighborhood Hits	387	Shared Neighborhood Hits	121
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

EPHA2_HUMAN
NC score	0.218617 (rank : 361)	θ value	0.000158464 (rank : 255)
Query Neighborhood Hits	495	Target Neighborhood Hits	1021	Shared Neighborhood Hits	177
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

PTPRV_MOUSE
NC score	0.218068 (rank : 362)	θ value	0.000158464 (rank : 258)
Query Neighborhood Hits	495	Target Neighborhood Hits	179	Shared Neighborhood Hits	84
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

JAML1_MOUSE
NC score	0.217588 (rank : 363)	θ value	8.99809 (rank : 484)
Query Neighborhood Hits	495	Target Neighborhood Hits	185	Shared Neighborhood Hits	118
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

LRRC4_MOUSE
NC score	0.217175 (rank : 364)	θ value	1.87187e-05 (rank : 230)
Query Neighborhood Hits	495	Target Neighborhood Hits	412	Shared Neighborhood Hits	171
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

CRLF1_MOUSE
NC score	0.216423 (rank : 365)	θ value	0.00134147 (rank : 291)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

EPHA6_HUMAN
NC score	0.216314 (rank : 366)	θ value	3.19293e-05 (rank : 239)
Query Neighborhood Hits	495	Target Neighborhood Hits	959	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

IL27B_HUMAN
NC score	0.212689 (rank : 367)	θ value	0.000602161 (rank : 280)
Query Neighborhood Hits	495	Target Neighborhood Hits	80	Shared Neighborhood Hits	66
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

EPHA2_MOUSE
NC score	0.211549 (rank : 368)	θ value	0.00390308 (rank : 318)
Query Neighborhood Hits	495	Target Neighborhood Hits	1020	Shared Neighborhood Hits	169
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA5_MOUSE
NC score	0.210143 (rank : 369)	θ value	5.26297e-08 (rank : 180)
Query Neighborhood Hits	495	Target Neighborhood Hits	950	Shared Neighborhood Hits	179
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

HHLA2_HUMAN
NC score	0.208224 (rank : 370)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

EPHA6_MOUSE
NC score	0.207422 (rank : 371)	θ value	2.44474e-05 (rank : 233)
Query Neighborhood Hits	495	Target Neighborhood Hits	946	Shared Neighborhood Hits	156
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FCERA_HUMAN
NC score	0.207335 (rank : 372)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	495	Target Neighborhood Hits	150	Shared Neighborhood Hits	117
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

EPHAA_HUMAN
NC score	0.207188 (rank : 373)	θ value	0.0563607 (rank : 363)
Query Neighborhood Hits	495	Target Neighborhood Hits	960	Shared Neighborhood Hits	157
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FCGR1_HUMAN
NC score	0.207035 (rank : 374)	θ value	3.0926 (rank : 440)
Query Neighborhood Hits	495	Target Neighborhood Hits	145	Shared Neighborhood Hits	108
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

PTPRJ_MOUSE
NC score	0.202520 (rank : 375)	θ value	0.21417 (rank : 384)
Query Neighborhood Hits	495	Target Neighborhood Hits	188	Shared Neighborhood Hits	96
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRJ_HUMAN
NC score	0.199234 (rank : 376)	θ value	2.36792 (rank : 436)
Query Neighborhood Hits	495	Target Neighborhood Hits	207	Shared Neighborhood Hits	102
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

INSRR_HUMAN
NC score	0.198688 (rank : 377)	θ value	0.00020696 (rank : 261)
Query Neighborhood Hits	495	Target Neighborhood Hits	950	Shared Neighborhood Hits	142
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
NC score	0.198677 (rank : 378)	θ value	0.00175202 (rank : 304)
Query Neighborhood Hits	495	Target Neighborhood Hits	961	Shared Neighborhood Hits	142
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

NTRK1_HUMAN
NC score	0.197171 (rank : 379)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	495	Target Neighborhood Hits	1023	Shared Neighborhood Hits	197
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

CD80_HUMAN
NC score	0.196694 (rank : 380)	θ value	0.62314 (rank : 402)
Query Neighborhood Hits	495	Target Neighborhood Hits	129	Shared Neighborhood Hits	103
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

RIMB2_HUMAN
NC score	0.194120 (rank : 381)	θ value	0.00134147 (rank : 299)
Query Neighborhood Hits	495	Target Neighborhood Hits	263	Shared Neighborhood Hits	64
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

LAG3_MOUSE
NC score	0.193397 (rank : 382)	θ value	8.99809 (rank : 485)
Query Neighborhood Hits	495	Target Neighborhood Hits	117	Shared Neighborhood Hits	91
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

FLT3_MOUSE
NC score	0.192611 (rank : 383)	θ value	0.279714 (rank : 388)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	139
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

IGF1R_HUMAN
NC score	0.191636 (rank : 384)	θ value	0.0113563 (rank : 332)
Query Neighborhood Hits	495	Target Neighborhood Hits	977	Shared Neighborhood Hits	144
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSR_MOUSE
NC score	0.190775 (rank : 385)	θ value	0.00134147 (rank : 294)
Query Neighborhood Hits	495	Target Neighborhood Hits	968	Shared Neighborhood Hits	143
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IGF1R_MOUSE
NC score	0.189938 (rank : 386)	θ value	0.0431538 (rank : 355)
Query Neighborhood Hits	495	Target Neighborhood Hits	973	Shared Neighborhood Hits	144
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

RIMB2_MOUSE
NC score	0.188449 (rank : 387)	θ value	2.44474e-05 (rank : 236)
Query Neighborhood Hits	495	Target Neighborhood Hits	246	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

OX2G_MOUSE
NC score	0.188299 (rank : 388)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	495	Target Neighborhood Hits	105	Shared Neighborhood Hits	90
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

EPHA1_MOUSE
NC score	0.187058 (rank : 389)	θ value	0.813845 (rank : 409)
Query Neighborhood Hits	495	Target Neighborhood Hits	958	Shared Neighborhood Hits	149
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

INSR_HUMAN
NC score	0.186188 (rank : 390)	θ value	0.00175202 (rank : 305)
Query Neighborhood Hits	495	Target Neighborhood Hits	963	Shared Neighborhood Hits	139
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

CD80_MOUSE
NC score	0.185905 (rank : 391)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	495	Target Neighborhood Hits	136	Shared Neighborhood Hits	105
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

TRIO_HUMAN
NC score	0.183840 (rank : 392)	θ value	0.000602161 (rank : 282)
Query Neighborhood Hits	495	Target Neighborhood Hits	1580	Shared Neighborhood Hits	283
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ILRL1_MOUSE
NC score	0.181960 (rank : 393)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	495	Target Neighborhood Hits	172	Shared Neighborhood Hits	129
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

CT075_MOUSE
NC score	0.181889 (rank : 394)	θ value	0.000786445 (rank : 283)
Query Neighborhood Hits	495	Target Neighborhood Hits	358	Shared Neighborhood Hits	101
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

EPHA1_HUMAN
NC score	0.180851 (rank : 395)	θ value	0.279714 (rank : 387)
Query Neighborhood Hits	495	Target Neighborhood Hits	997	Shared Neighborhood Hits	140
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

I27RA_HUMAN
NC score	0.180500 (rank : 396)	θ value	1.06291 (rank : 416)
Query Neighborhood Hits	495	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

ANKF1_HUMAN
NC score	0.180112 (rank : 397)	θ value	0.0961366 (rank : 371)
Query Neighborhood Hits	495	Target Neighborhood Hits	126	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

FCGR1_MOUSE
NC score	0.179515 (rank : 398)	θ value	0.163984 (rank : 377)
Query Neighborhood Hits	495	Target Neighborhood Hits	123	Shared Neighborhood Hits	92
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

PTPRO_HUMAN
NC score	0.176128 (rank : 399)	θ value	0.0563607 (rank : 365)
Query Neighborhood Hits	495	Target Neighborhood Hits	139	Shared Neighborhood Hits	63
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

SHPS1_HUMAN
NC score	0.176059 (rank : 400)	θ value	0.0563607 (rank : 366)
Query Neighborhood Hits	495	Target Neighborhood Hits	455	Shared Neighborhood Hits	121
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

CD79A_HUMAN
NC score	0.175819 (rank : 401)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	495	Target Neighborhood Hits	102	Shared Neighborhood Hits	63
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

I11RB_MOUSE
NC score	0.172975 (rank : 402)	θ value	0.00665767 (rank : 327)
Query Neighborhood Hits	495	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

OX2G_HUMAN
NC score	0.172360 (rank : 403)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	495	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

FLT3_HUMAN
NC score	0.172034 (rank : 404)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	132
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

PDL2_HUMAN
NC score	0.171071 (rank : 405)	θ value	θ > 10 (rank : 977)
Query Neighborhood Hits	495	Target Neighborhood Hits	114	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

ILRL2_HUMAN
NC score	0.169767 (rank : 406)	θ value	0.47712 (rank : 398)
Query Neighborhood Hits	495	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

ICAM1_MOUSE
NC score	0.169517 (rank : 407)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	495	Target Neighborhood Hits	99	Shared Neighborhood Hits	86
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

I12R1_HUMAN
NC score	0.169317 (rank : 408)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	495	Target Neighborhood Hits	78	Shared Neighborhood Hits	64
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

LAG3_HUMAN
NC score	0.166547 (rank : 409)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	495	Target Neighborhood Hits	129	Shared Neighborhood Hits	81
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

I12R1_MOUSE
NC score	0.165527 (rank : 410)	θ value	0.0736092 (rank : 368)
Query Neighborhood Hits	495	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

SIRB1_HUMAN
NC score	0.162159 (rank : 411)	θ value	0.125558 (rank : 374)
Query Neighborhood Hits	495	Target Neighborhood Hits	422	Shared Neighborhood Hits	108
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

I11RA_MOUSE
NC score	0.160864 (rank : 412)	θ value	0.00869519 (rank : 329)
Query Neighborhood Hits	495	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

FCRLA_HUMAN
NC score	0.153524 (rank : 413)	θ value	0.000461057 (rank : 277)
Query Neighborhood Hits	495	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

I11RA_HUMAN
NC score	0.152283 (rank : 414)	θ value	0.21417 (rank : 383)
Query Neighborhood Hits	495	Target Neighborhood Hits	138	Shared Neighborhood Hits	75
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

RYK_HUMAN
NC score	0.150114 (rank : 415)	θ value	θ > 10 (rank : 1074)
Query Neighborhood Hits	495	Target Neighborhood Hits	701	Shared Neighborhood Hits	83
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
NC score	0.148219 (rank : 416)	θ value	θ > 10 (rank : 1075)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	82
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ICAM3_HUMAN
NC score	0.147218 (rank : 417)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	495	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

CD45_HUMAN
NC score	0.146241 (rank : 418)	θ value	0.0330416 (rank : 353)
Query Neighborhood Hits	495	Target Neighborhood Hits	243	Shared Neighborhood Hits	63
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

FCRLA_MOUSE
NC score	0.145897 (rank : 419)	θ value	0.00102713 (rank : 287)
Query Neighborhood Hits	495	Target Neighborhood Hits	110	Shared Neighborhood Hits	65
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

MFAP3_HUMAN
NC score	0.145752 (rank : 420)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	495	Target Neighborhood Hits	91	Shared Neighborhood Hits	82
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

EMB_HUMAN
NC score	0.145041 (rank : 421)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	495	Target Neighborhood Hits	54	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

LTK_HUMAN
NC score	0.144962 (rank : 422)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	495	Target Neighborhood Hits	774	Shared Neighborhood Hits	87
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
NC score	0.144738 (rank : 423)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	495	Target Neighborhood Hits	770	Shared Neighborhood Hits	85
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

HCFC1_MOUSE
NC score	0.144517 (rank : 424)	θ value	0.0148317 (rank : 340)
Query Neighborhood Hits	495	Target Neighborhood Hits	348	Shared Neighborhood Hits	69
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

AMGO2_HUMAN
NC score	0.143858 (rank : 425)	θ value	0.163984 (rank : 375)
Query Neighborhood Hits	495	Target Neighborhood Hits	357	Shared Neighborhood Hits	135
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

ALK_MOUSE
NC score	0.143301 (rank : 426)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	495	Target Neighborhood Hits	811	Shared Neighborhood Hits	92
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

CD4_HUMAN
NC score	0.142703 (rank : 427)	θ value	0.365318 (rank : 390)
Query Neighborhood Hits	495	Target Neighborhood Hits	122	Shared Neighborhood Hits	60
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

ALK_HUMAN
NC score	0.142167 (rank : 428)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	495	Target Neighborhood Hits	795	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ICAM1_HUMAN
NC score	0.140716 (rank : 429)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	495	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

STYK1_MOUSE
NC score	0.140646 (rank : 430)	θ value	θ > 10 (rank : 1123)
Query Neighborhood Hits	495	Target Neighborhood Hits	779	Shared Neighborhood Hits	86
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

IGSF2_HUMAN
NC score	0.140152 (rank : 431)	θ value	6.88961 (rank : 469)
Query Neighborhood Hits	495	Target Neighborhood Hits	208	Shared Neighborhood Hits	106
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

IL6RA_MOUSE
NC score	0.138980 (rank : 432)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	495	Target Neighborhood Hits	104	Shared Neighborhood Hits	79
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

CD45_MOUSE
NC score	0.138754 (rank : 433)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	495	Target Neighborhood Hits	178	Shared Neighborhood Hits	51
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

RET_MOUSE
NC score	0.137807 (rank : 434)	θ value	θ > 10 (rank : 1058)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	87
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

STYK1_HUMAN
NC score	0.137753 (rank : 435)	θ value	θ > 10 (rank : 1122)
Query Neighborhood Hits	495	Target Neighborhood Hits	786	Shared Neighborhood Hits	87
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

DDR1_HUMAN
NC score	0.137667 (rank : 436)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	495	Target Neighborhood Hits	819	Shared Neighborhood Hits	87
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
NC score	0.137590 (rank : 437)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	495	Target Neighborhood Hits	818	Shared Neighborhood Hits	87
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

RET_HUMAN
NC score	0.136960 (rank : 438)	θ value	θ > 10 (rank : 1057)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	84
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

BTNL2_HUMAN
NC score	0.136848 (rank : 439)	θ value	0.62314 (rank : 401)
Query Neighborhood Hits	495	Target Neighborhood Hits	164	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

FPRP_HUMAN
NC score	0.135488 (rank : 440)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	495	Target Neighborhood Hits	130	Shared Neighborhood Hits	94
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

TPSNR_MOUSE
NC score	0.134805 (rank : 441)	θ value	0.21417 (rank : 386)
Query Neighborhood Hits	495	Target Neighborhood Hits	336	Shared Neighborhood Hits	100
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

DDR2_HUMAN
NC score	0.134484 (rank : 442)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	495	Target Neighborhood Hits	818	Shared Neighborhood Hits	87
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
NC score	0.133335 (rank : 443)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	495	Target Neighborhood Hits	813	Shared Neighborhood Hits	87
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FCG2B_HUMAN
NC score	0.131788 (rank : 444)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	82
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

MOX2R_HUMAN
NC score	0.131366 (rank : 445)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	495	Target Neighborhood Hits	51	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

FCG2C_HUMAN
NC score	0.131250 (rank : 446)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	495	Target Neighborhood Hits	118	Shared Neighborhood Hits	83
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

TNK1_HUMAN
NC score	0.130330 (rank : 447)	θ value	θ > 10 (rank : 1151)
Query Neighborhood Hits	495	Target Neighborhood Hits	815	Shared Neighborhood Hits	86
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

AATK_MOUSE
NC score	0.128660 (rank : 448)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	495	Target Neighborhood Hits	942	Shared Neighborhood Hits	89
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

TNK1_MOUSE
NC score	0.128186 (rank : 449)	θ value	θ > 10 (rank : 1152)
Query Neighborhood Hits	495	Target Neighborhood Hits	806	Shared Neighborhood Hits	90
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

RON_MOUSE
NC score	0.127993 (rank : 450)	θ value	θ > 10 (rank : 1069)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	84
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FAK2_HUMAN
NC score	0.127979 (rank : 451)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

MET_MOUSE
NC score	0.127830 (rank : 452)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	495	Target Neighborhood Hits	844	Shared Neighborhood Hits	85
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_HUMAN
NC score	0.127748 (rank : 453)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	495	Target Neighborhood Hits	831	Shared Neighborhood Hits	85
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

FAK1_HUMAN
NC score	0.127476 (rank : 454)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK2_MOUSE
NC score	0.127299 (rank : 455)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK1_MOUSE
NC score	0.127148 (rank : 456)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

ACK1_MOUSE
NC score	0.126884 (rank : 457)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	495	Target Neighborhood Hits	1080	Shared Neighborhood Hits	93
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

FPRP_MOUSE
NC score	0.126450 (rank : 458)	θ value	1.38821 (rank : 418)
Query Neighborhood Hits	495	Target Neighborhood Hits	116	Shared Neighborhood Hits	73
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

ERBB3_HUMAN
NC score	0.126125 (rank : 459)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	495	Target Neighborhood Hits	918	Shared Neighborhood Hits	87
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

RON_HUMAN
NC score	0.125992 (rank : 460)	θ value	θ > 10 (rank : 1068)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	84
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

AATK_HUMAN
NC score	0.125903 (rank : 461)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	495	Target Neighborhood Hits	1243	Shared Neighborhood Hits	94
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

MFAP3_MOUSE
NC score	0.125705 (rank : 462)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	495	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

ACK1_HUMAN
NC score	0.125641 (rank : 463)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	495	Target Neighborhood Hits	1140	Shared Neighborhood Hits	94
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ERBB2_HUMAN
NC score	0.125638 (rank : 464)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	495	Target Neighborhood Hits	1073	Shared Neighborhood Hits	95
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
NC score	0.125249 (rank : 465)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	495	Target Neighborhood Hits	918	Shared Neighborhood Hits	90
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB4_HUMAN
NC score	0.124664 (rank : 466)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	495	Target Neighborhood Hits	910	Shared Neighborhood Hits	93
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERBB3_MOUSE
NC score	0.124531 (rank : 467)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	495	Target Neighborhood Hits	898	Shared Neighborhood Hits	85
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

PTPRZ_HUMAN
NC score	0.124324 (rank : 468)	θ value	0.00390308 (rank : 321)
Query Neighborhood Hits	495	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

EGFR_MOUSE
NC score	0.123802 (rank : 469)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	495	Target Neighborhood Hits	927	Shared Neighborhood Hits	92
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ZAP70_MOUSE
NC score	0.123739 (rank : 470)	θ value	θ > 10 (rank : 1183)
Query Neighborhood Hits	495	Target Neighborhood Hits	905	Shared Neighborhood Hits	86
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

EGFR_HUMAN
NC score	0.123290 (rank : 471)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	495	Target Neighborhood Hits	939	Shared Neighborhood Hits	88
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

KSYK_HUMAN
NC score	0.122885 (rank : 472)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	495	Target Neighborhood Hits	901	Shared Neighborhood Hits	86
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
NC score	0.122751 (rank : 473)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	495	Target Neighborhood Hits	944	Shared Neighborhood Hits	87
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LEPR_MOUSE
NC score	0.122720 (rank : 474)	θ value	1.81305 (rank : 431)
Query Neighborhood Hits	495	Target Neighborhood Hits	109	Shared Neighborhood Hits	66
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

ZAP70_HUMAN
NC score	0.122581 (rank : 475)	θ value	θ > 10 (rank : 1182)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	86
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

TPSNR_HUMAN
NC score	0.121706 (rank : 476)	θ value	2.36792 (rank : 437)
Query Neighborhood Hits	495	Target Neighborhood Hits	330	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

AMGO2_MOUSE
NC score	0.121076 (rank : 477)	θ value	0.813845 (rank : 405)
Query Neighborhood Hits	495	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

SRMS_HUMAN
NC score	0.120908 (rank : 478)	θ value	θ > 10 (rank : 1097)
Query Neighborhood Hits	495	Target Neighborhood Hits	946	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FES_HUMAN
NC score	0.120350 (rank : 479)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	495	Target Neighborhood Hits	978	Shared Neighborhood Hits	85
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
NC score	0.120322 (rank : 480)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	85
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SRMS_MOUSE
NC score	0.119425 (rank : 481)	θ value	θ > 10 (rank : 1098)
Query Neighborhood Hits	495	Target Neighborhood Hits	964	Shared Neighborhood Hits	86
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

MATK_HUMAN
NC score	0.119140 (rank : 482)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	495	Target Neighborhood Hits	954	Shared Neighborhood Hits	86
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

PTPRG_HUMAN
NC score	0.118780 (rank : 483)	θ value	θ > 10 (rank : 1044)
Query Neighborhood Hits	495	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

LEPR_HUMAN
NC score	0.118668 (rank : 484)	θ value	4.03905 (rank : 450)
Query Neighborhood Hits	495	Target Neighborhood Hits	112	Shared Neighborhood Hits	73
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

MATK_MOUSE
NC score	0.118400 (rank : 485)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	495	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

HCFC1_HUMAN
NC score	0.117723 (rank : 486)	θ value	0.0736092 (rank : 367)
Query Neighborhood Hits	495	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

FER_HUMAN
NC score	0.117676 (rank : 487)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	495	Target Neighborhood Hits	1278	Shared Neighborhood Hits	89
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

PTPRG_MOUSE
NC score	0.117459 (rank : 488)	θ value	θ > 10 (rank : 1045)
Query Neighborhood Hits	495	Target Neighborhood Hits	260	Shared Neighborhood Hits	56
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

JAML1_HUMAN
NC score	0.117434 (rank : 489)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	495	Target Neighborhood Hits	108	Shared Neighborhood Hits	67
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

AMGO3_HUMAN
NC score	0.117101 (rank : 490)	θ value	6.88961 (rank : 466)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	87
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

BMX_MOUSE
NC score	0.115725 (rank : 491)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	495	Target Neighborhood Hits	912	Shared Neighborhood Hits	87
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

TXK_MOUSE
NC score	0.115488 (rank : 492)	θ value	θ > 10 (rank : 1165)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	86
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

HCK_MOUSE
NC score	0.115002 (rank : 493)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	495	Target Neighborhood Hits	1029	Shared Neighborhood Hits	87
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SHPS1_MOUSE
NC score	0.114922 (rank : 494)	θ value	0.47712 (rank : 399)
Query Neighborhood Hits	495	Target Neighborhood Hits	439	Shared Neighborhood Hits	100
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

ABL1_MOUSE
NC score	0.114879 (rank : 495)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	495	Target Neighborhood Hits	1178	Shared Neighborhood Hits	95
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BMX_HUMAN
NC score	0.114779 (rank : 496)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	495	Target Neighborhood Hits	942	Shared Neighborhood Hits	86
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

HCK_HUMAN
NC score	0.114663 (rank : 497)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	495	Target Neighborhood Hits	1035	Shared Neighborhood Hits	89
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ABL2_HUMAN
NC score	0.114592 (rank : 498)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	495	Target Neighborhood Hits	1045	Shared Neighborhood Hits	90
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

LCK_HUMAN
NC score	0.114390 (rank : 499)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	495	Target Neighborhood Hits	987	Shared Neighborhood Hits	88
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

TXK_HUMAN
NC score	0.114384 (rank : 500)	θ value	θ > 10 (rank : 1164)
Query Neighborhood Hits	495	Target Neighborhood Hits	971	Shared Neighborhood Hits	86
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BLK_MOUSE
NC score	0.114380 (rank : 501)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	495	Target Neighborhood Hits	992	Shared Neighborhood Hits	88
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ABL1_HUMAN
NC score	0.114297 (rank : 502)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	495	Target Neighborhood Hits	1220	Shared Neighborhood Hits	91
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ITK_MOUSE
NC score	0.114197 (rank : 503)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	495	Target Neighborhood Hits	985	Shared Neighborhood Hits	86
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

BTK_HUMAN
NC score	0.114128 (rank : 504)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	495	Target Neighborhood Hits	1026	Shared Neighborhood Hits	90
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FRK_HUMAN
NC score	0.114036 (rank : 505)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	495	Target Neighborhood Hits	1058	Shared Neighborhood Hits	87
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

BTK_MOUSE
NC score	0.114006 (rank : 506)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	495	Target Neighborhood Hits	1017	Shared Neighborhood Hits	90
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

LCK_MOUSE
NC score	0.113971 (rank : 507)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	495	Target Neighborhood Hits	981	Shared Neighborhood Hits	86
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PTK6_MOUSE
NC score	0.113923 (rank : 508)	θ value	θ > 10 (rank : 1007)
Query Neighborhood Hits	495	Target Neighborhood Hits	1026	Shared Neighborhood Hits	87
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SIGL9_HUMAN
NC score	0.113871 (rank : 509)	θ value	θ > 10 (rank : 1077)
Query Neighborhood Hits	495	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

AMGO3_MOUSE
NC score	0.113829 (rank : 510)	θ value	1.81305 (rank : 428)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	82
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ITK_HUMAN
NC score	0.113652 (rank : 511)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	495	Target Neighborhood Hits	1016	Shared Neighborhood Hits	86
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TEC_HUMAN
NC score	0.113648 (rank : 512)	θ value	θ > 10 (rank : 1128)
Query Neighborhood Hits	495	Target Neighborhood Hits	1006	Shared Neighborhood Hits	86
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CSK_HUMAN
NC score	0.113523 (rank : 513)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	90
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

PTPRE_MOUSE
NC score	0.113280 (rank : 514)	θ value	θ > 10 (rank : 1043)
Query Neighborhood Hits	495	Target Neighborhood Hits	86	Shared Neighborhood Hits	19
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

TEC_MOUSE
NC score	0.113255 (rank : 515)	θ value	θ > 10 (rank : 1129)
Query Neighborhood Hits	495	Target Neighborhood Hits	1006	Shared Neighborhood Hits	87
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BLK_HUMAN
NC score	0.113209 (rank : 516)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	495	Target Neighborhood Hits	994	Shared Neighborhood Hits	87
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PTPRA_HUMAN
NC score	0.113187 (rank : 517)	θ value	θ > 10 (rank : 1040)
Query Neighborhood Hits	495	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRE_HUMAN
NC score	0.113021 (rank : 518)	θ value	θ > 10 (rank : 1042)
Query Neighborhood Hits	495	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

FGR_HUMAN
NC score	0.112785 (rank : 519)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	495	Target Neighborhood Hits	1067	Shared Neighborhood Hits	91
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
NC score	0.112669 (rank : 520)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	495	Target Neighborhood Hits	1069	Shared Neighborhood Hits	91
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LYN_MOUSE
NC score	0.112656 (rank : 521)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	495	Target Neighborhood Hits	1023	Shared Neighborhood Hits	88
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PTPRA_MOUSE
NC score	0.112636 (rank : 522)	θ value	θ > 10 (rank : 1041)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	19
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

YES_MOUSE
NC score	0.112431 (rank : 523)	θ value	θ > 10 (rank : 1180)
Query Neighborhood Hits	495	Target Neighborhood Hits	1052	Shared Neighborhood Hits	93
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

LYN_HUMAN
NC score	0.112411 (rank : 524)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	495	Target Neighborhood Hits	1022	Shared Neighborhood Hits	86
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

YES_HUMAN
NC score	0.112367 (rank : 525)	θ value	θ > 10 (rank : 1179)
Query Neighborhood Hits	495	Target Neighborhood Hits	1059	Shared Neighborhood Hits	92
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SRC_MOUSE
NC score	0.112234 (rank : 526)	θ value	θ > 10 (rank : 1093)
Query Neighborhood Hits	495	Target Neighborhood Hits	1033	Shared Neighborhood Hits	89
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

JAK1_MOUSE
NC score	0.112202 (rank : 527)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_HUMAN
NC score	0.112167 (rank : 528)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

SRC_HUMAN
NC score	0.111796 (rank : 529)	θ value	θ > 10 (rank : 1092)
Query Neighborhood Hits	495	Target Neighborhood Hits	1058	Shared Neighborhood Hits	91
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

CSK_MOUSE
NC score	0.111639 (rank : 530)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	90
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PTK6_HUMAN
NC score	0.111443 (rank : 531)	θ value	θ > 10 (rank : 1006)
Query Neighborhood Hits	495	Target Neighborhood Hits	1020	Shared Neighborhood Hits	87
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

LY9_MOUSE
NC score	0.110992 (rank : 532)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	495	Target Neighborhood Hits	110	Shared Neighborhood Hits	74
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

JAK3_HUMAN
NC score	0.110763 (rank : 533)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	495	Target Neighborhood Hits	827	Shared Neighborhood Hits	85
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

FYN_MOUSE
NC score	0.110175 (rank : 534)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	495	Target Neighborhood Hits	1073	Shared Neighborhood Hits	89
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

IL6RA_HUMAN
NC score	0.109951 (rank : 535)	θ value	6.88961 (rank : 470)
Query Neighborhood Hits	495	Target Neighborhood Hits	96	Shared Neighborhood Hits	61
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

JAK2_HUMAN
NC score	0.109404 (rank : 536)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

FYN_HUMAN
NC score	0.109326 (rank : 537)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	495	Target Neighborhood Hits	1078	Shared Neighborhood Hits	89
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

JAK2_MOUSE
NC score	0.109097 (rank : 538)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	85
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

TYK2_MOUSE
NC score	0.108527 (rank : 539)	θ value	θ > 10 (rank : 1167)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

BT3A2_HUMAN
NC score	0.107908 (rank : 540)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	495	Target Neighborhood Hits	158	Shared Neighborhood Hits	94
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

SIRPG_HUMAN
NC score	0.107877 (rank : 541)	θ value	3.0926 (rank : 444)
Query Neighborhood Hits	495	Target Neighborhood Hits	359	Shared Neighborhood Hits	87
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

AMGO1_HUMAN
NC score	0.107552 (rank : 542)	θ value	3.0926 (rank : 439)
Query Neighborhood Hits	495	Target Neighborhood Hits	353	Shared Neighborhood Hits	104
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

TYK2_HUMAN
NC score	0.107403 (rank : 543)	θ value	θ > 10 (rank : 1166)
Query Neighborhood Hits	495	Target Neighborhood Hits	841	Shared Neighborhood Hits	85
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_MOUSE
NC score	0.107234 (rank : 544)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	495	Target Neighborhood Hits	821	Shared Neighborhood Hits	85
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

FCG2A_HUMAN
NC score	0.106652 (rank : 545)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	495	Target Neighborhood Hits	92	Shared Neighborhood Hits	71
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

CD226_HUMAN
NC score	0.105801 (rank : 546)	θ value	0.813845 (rank : 407)
Query Neighborhood Hits	495	Target Neighborhood Hits	87	Shared Neighborhood Hits	67
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

I27RA_MOUSE
NC score	0.105125 (rank : 547)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	495	Target Neighborhood Hits	55	Shared Neighborhood Hits	41
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

GUC2C_HUMAN
NC score	0.101719 (rank : 548)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	495	Target Neighborhood Hits	624	Shared Neighborhood Hits	80
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

PRLR_HUMAN
NC score	0.099772 (rank : 549)	θ value	0.0431538 (rank : 358)
Query Neighborhood Hits	495	Target Neighborhood Hits	95	Shared Neighborhood Hits	51
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

GUC2F_HUMAN
NC score	0.099309 (rank : 550)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	495	Target Neighborhood Hits	740	Shared Neighborhood Hits	84
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

MLKL_HUMAN
NC score	0.098921 (rank : 551)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	495	Target Neighborhood Hits	600	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

PRLR_MOUSE
NC score	0.098077 (rank : 552)	θ value	0.365318 (rank : 393)
Query Neighborhood Hits	495	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

M3KL4_HUMAN
NC score	0.097898 (rank : 553)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	495	Target Neighborhood Hits	1087	Shared Neighborhood Hits	90
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

LRRK1_MOUSE
NC score	0.097154 (rank : 554)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	495	Target Neighborhood Hits	1267	Shared Neighborhood Hits	128
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

CD48_MOUSE
NC score	0.096628 (rank : 555)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	495	Target Neighborhood Hits	96	Shared Neighborhood Hits	60
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

MLTK_MOUSE
NC score	0.095505 (rank : 556)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.095358 (rank : 557)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

IL27B_MOUSE
NC score	0.095208 (rank : 558)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	495	Target Neighborhood Hits	55	Shared Neighborhood Hits	41
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

M3K12_MOUSE
NC score	0.094672 (rank : 559)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	495	Target Neighborhood Hits	957	Shared Neighborhood Hits	91
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

LRRK1_HUMAN
NC score	0.094494 (rank : 560)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	495	Target Neighborhood Hits	1237	Shared Neighborhood Hits	126
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

M3K12_HUMAN
NC score	0.094493 (rank : 561)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	495	Target Neighborhood Hits	940	Shared Neighborhood Hits	89
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K9_HUMAN
NC score	0.094098 (rank : 562)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	495	Target Neighborhood Hits	1123	Shared Neighborhood Hits	92
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.094094 (rank : 563)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	495	Target Neighborhood Hits	1071	Shared Neighborhood Hits	91
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
NC score	0.093566 (rank : 564)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	495	Target Neighborhood Hits	1136	Shared Neighborhood Hits	96
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

BT1A1_MOUSE
NC score	0.093491 (rank : 565)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	495	Target Neighborhood Hits	252	Shared Neighborhood Hits	123
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

MLKL_MOUSE
NC score	0.093244 (rank : 566)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	495	Target Neighborhood Hits	707	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ARAF_MOUSE
NC score	0.092942 (rank : 567)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	86
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

RAF1_MOUSE
NC score	0.092604 (rank : 568)	θ value	θ > 10 (rank : 1056)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	87
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ARAF_HUMAN
NC score	0.092603 (rank : 569)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	495	Target Neighborhood Hits	924	Shared Neighborhood Hits	87
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

BRAF1_HUMAN
NC score	0.092527 (rank : 570)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	495	Target Neighborhood Hits	883	Shared Neighborhood Hits	87
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

I18RA_MOUSE
NC score	0.092441 (rank : 571)	θ value	1.38821 (rank : 419)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

M3K13_HUMAN
NC score	0.092188 (rank : 572)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	86
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

RAF1_HUMAN
NC score	0.091877 (rank : 573)	θ value	θ > 10 (rank : 1055)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	86
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ILK_MOUSE
NC score	0.091821 (rank : 574)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	86
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.091386 (rank : 575)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	86
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

CEAMA_MOUSE
NC score	0.091289 (rank : 576)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	495	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

CD48_HUMAN
NC score	0.090682 (rank : 577)	θ value	2.36792 (rank : 434)
Query Neighborhood Hits	495	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

SIGIR_MOUSE
NC score	0.090383 (rank : 578)	θ value	4.03905 (rank : 451)
Query Neighborhood Hits	495	Target Neighborhood Hits	95	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

TESK2_HUMAN
NC score	0.090214 (rank : 579)	θ value	θ > 10 (rank : 1132)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

PTN9_MOUSE
NC score	0.090210 (rank : 580)	θ value	θ > 10 (rank : 1037)
Query Neighborhood Hits	495	Target Neighborhood Hits	78	Shared Neighborhood Hits	18
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

TESK2_MOUSE
NC score	0.090110 (rank : 581)	θ value	θ > 10 (rank : 1133)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

M3K7_MOUSE
NC score	0.090070 (rank : 582)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	495	Target Neighborhood Hits	892	Shared Neighborhood Hits	85
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.090019 (rank : 583)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	495	Target Neighborhood Hits	892	Shared Neighborhood Hits	85
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

PTN9_HUMAN
NC score	0.089902 (rank : 584)	θ value	θ > 10 (rank : 1036)
Query Neighborhood Hits	495	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN7_HUMAN
NC score	0.089889 (rank : 585)	θ value	θ > 10 (rank : 1034)
Query Neighborhood Hits	495	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
NC score	0.089882 (rank : 586)	θ value	θ > 10 (rank : 1035)
Query Neighborhood Hits	495	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

KSR1_MOUSE
NC score	0.089703 (rank : 587)	θ value	1.38821 (rank : 421)
Query Neighborhood Hits	495	Target Neighborhood Hits	870	Shared Neighborhood Hits	88
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

PTN5_HUMAN
NC score	0.089606 (rank : 588)	θ value	θ > 10 (rank : 1030)
Query Neighborhood Hits	495	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

GP125_MOUSE
NC score	0.089597 (rank : 589)	θ value	4.03905 (rank : 447)
Query Neighborhood Hits	495	Target Neighborhood Hits	329	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

PTN5_MOUSE
NC score	0.089573 (rank : 590)	θ value	θ > 10 (rank : 1031)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

ILK2_HUMAN
NC score	0.089348 (rank : 591)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	495	Target Neighborhood Hits	848	Shared Neighborhood Hits	86
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

GP125_HUMAN
NC score	0.089158 (rank : 592)	θ value	1.06291 (rank : 415)
Query Neighborhood Hits	495	Target Neighborhood Hits	327	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

KSR1_HUMAN
NC score	0.088798 (rank : 593)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

BT1A1_HUMAN
NC score	0.088779 (rank : 594)	θ value	0.125558 (rank : 372)
Query Neighborhood Hits	495	Target Neighborhood Hits	322	Shared Neighborhood Hits	120
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

PTN2_HUMAN
NC score	0.088713 (rank : 595)	θ value	θ > 10 (rank : 1026)
Query Neighborhood Hits	495	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

AMGO1_MOUSE
NC score	0.088654 (rank : 596)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	495	Target Neighborhood Hits	325	Shared Neighborhood Hits	85
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

MOS_HUMAN
NC score	0.088216 (rank : 597)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	495	Target Neighborhood Hits	829	Shared Neighborhood Hits	85
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

I18RA_HUMAN
NC score	0.088174 (rank : 598)	θ value	1.81305 (rank : 430)
Query Neighborhood Hits	495	Target Neighborhood Hits	97	Shared Neighborhood Hits	64
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

PTPRN_MOUSE
NC score	0.088168 (rank : 599)	θ value	θ > 10 (rank : 1047)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	26
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

GP116_HUMAN
NC score	0.088084 (rank : 600)	θ value	0.813845 (rank : 410)
Query Neighborhood Hits	495	Target Neighborhood Hits	167	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

PTN2_MOUSE
NC score	0.088076 (rank : 601)	θ value	θ > 10 (rank : 1027)
Query Neighborhood Hits	495	Target Neighborhood Hits	107	Shared Neighborhood Hits	19
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTPR2_MOUSE
NC score	0.087753 (rank : 602)	θ value	θ > 10 (rank : 1039)
Query Neighborhood Hits	495	Target Neighborhood Hits	120	Shared Neighborhood Hits	19
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

RIPK1_MOUSE
NC score	0.087692 (rank : 603)	θ value	θ > 10 (rank : 1060)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	86
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

PTPRR_MOUSE
NC score	0.087602 (rank : 604)	θ value	θ > 10 (rank : 1049)
Query Neighborhood Hits	495	Target Neighborhood Hits	84	Shared Neighborhood Hits	19
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRR_HUMAN
NC score	0.087594 (rank : 605)	θ value	θ > 10 (rank : 1048)
Query Neighborhood Hits	495	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPR2_HUMAN
NC score	0.087574 (rank : 606)	θ value	θ > 10 (rank : 1038)
Query Neighborhood Hits	495	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPRN_HUMAN
NC score	0.087530 (rank : 607)	θ value	θ > 10 (rank : 1046)
Query Neighborhood Hits	495	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTN1_HUMAN
NC score	0.087318 (rank : 608)	θ value	θ > 10 (rank : 1018)
Query Neighborhood Hits	495	Target Neighborhood Hits	84	Shared Neighborhood Hits	19
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
NC score	0.087263 (rank : 609)	θ value	θ > 10 (rank : 1019)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

CEAM3_HUMAN
NC score	0.087029 (rank : 610)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	495	Target Neighborhood Hits	28	Shared Neighborhood Hits	24
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

RIPK1_HUMAN
NC score	0.086846 (rank : 611)	θ value	θ > 10 (rank : 1059)
Query Neighborhood Hits	495	Target Neighborhood Hits	891	Shared Neighborhood Hits	86
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

PTN22_HUMAN
NC score	0.086833 (rank : 612)	θ value	θ > 10 (rank : 1022)
Query Neighborhood Hits	495	Target Neighborhood Hits	109	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

IRAK3_MOUSE
NC score	0.086582 (rank : 613)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	495	Target Neighborhood Hits	628	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK3_HUMAN
NC score	0.086570 (rank : 614)	θ value	θ > 10 (rank : 1063)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK2_MOUSE
NC score	0.086448 (rank : 615)	θ value	θ > 10 (rank : 1062)
Query Neighborhood Hits	495	Target Neighborhood Hits	776	Shared Neighborhood Hits	84
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

PTN18_MOUSE
NC score	0.086340 (rank : 616)	θ value	θ > 10 (rank : 1017)
Query Neighborhood Hits	495	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

TESK1_MOUSE
NC score	0.085643 (rank : 617)	θ value	θ > 10 (rank : 1131)
Query Neighborhood Hits	495	Target Neighborhood Hits	862	Shared Neighborhood Hits	86
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

GUC2E_MOUSE
NC score	0.085618 (rank : 618)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	495	Target Neighborhood Hits	692	Shared Neighborhood Hits	83
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

PTN18_HUMAN
NC score	0.085617 (rank : 619)	θ value	θ > 10 (rank : 1016)
Query Neighborhood Hits	495	Target Neighborhood Hits	73	Shared Neighborhood Hits	18
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

IL1AP_MOUSE
NC score	0.085516 (rank : 620)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	495	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

PTN12_HUMAN
NC score	0.085120 (rank : 621)	θ value	θ > 10 (rank : 1010)
Query Neighborhood Hits	495	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

LIMK1_HUMAN
NC score	0.085062 (rank : 622)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	495	Target Neighborhood Hits	1005	Shared Neighborhood Hits	86
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.084960 (rank : 623)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	495	Target Neighborhood Hits	1008	Shared Neighborhood Hits	86
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

TESK1_HUMAN
NC score	0.084801 (rank : 624)	θ value	θ > 10 (rank : 1130)
Query Neighborhood Hits	495	Target Neighborhood Hits	864	Shared Neighborhood Hits	85
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

PTN12_MOUSE
NC score	0.084715 (rank : 625)	θ value	θ > 10 (rank : 1011)
Query Neighborhood Hits	495	Target Neighborhood Hits	123	Shared Neighborhood Hits	20
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

LIMK2_HUMAN
NC score	0.084380 (rank : 626)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	495	Target Neighborhood Hits	986	Shared Neighborhood Hits	85
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

PTN22_MOUSE
NC score	0.084366 (rank : 627)	θ value	θ > 10 (rank : 1023)
Query Neighborhood Hits	495	Target Neighborhood Hits	179	Shared Neighborhood Hits	21
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

LIMK2_MOUSE
NC score	0.084271 (rank : 628)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	495	Target Neighborhood Hits	998	Shared Neighborhood Hits	85
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ICOSL_MOUSE
NC score	0.083792 (rank : 629)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

TMM25_MOUSE
NC score	0.083778 (rank : 630)	θ value	5.27518 (rank : 464)
Query Neighborhood Hits	495	Target Neighborhood Hits	46	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

RIPK2_HUMAN
NC score	0.083498 (rank : 631)	θ value	θ > 10 (rank : 1061)
Query Neighborhood Hits	495	Target Neighborhood Hits	774	Shared Neighborhood Hits	83
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

BTNL1_MOUSE
NC score	0.083260 (rank : 632)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	495	Target Neighborhood Hits	151	Shared Neighborhood Hits	83
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

MOS_MOUSE
NC score	0.083235 (rank : 633)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	86
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

CD244_HUMAN
NC score	0.083026 (rank : 634)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	495	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

IRAK4_HUMAN
NC score	0.082816 (rank : 635)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	495	Target Neighborhood Hits	816	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

LRRK2_HUMAN
NC score	0.082588 (rank : 636)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	495	Target Neighborhood Hits	1382	Shared Neighborhood Hits	121
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

TOPK_MOUSE
NC score	0.081912 (rank : 637)	θ value	θ > 10 (rank : 1154)
Query Neighborhood Hits	495	Target Neighborhood Hits	618	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TEX14_HUMAN
NC score	0.081393 (rank : 638)	θ value	θ > 10 (rank : 1134)
Query Neighborhood Hits	495	Target Neighborhood Hits	1103	Shared Neighborhood Hits	92
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

VASN_MOUSE
NC score	0.081169 (rank : 639)	θ value	0.365318 (rank : 395)
Query Neighborhood Hits	495	Target Neighborhood Hits	426	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

PTN6_HUMAN
NC score	0.080841 (rank : 640)	θ value	θ > 10 (rank : 1032)
Query Neighborhood Hits	495	Target Neighborhood Hits	234	Shared Neighborhood Hits	22
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

LRRK2_MOUSE
NC score	0.080733 (rank : 641)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	495	Target Neighborhood Hits	1359	Shared Neighborhood Hits	124
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

TOPK_HUMAN
NC score	0.080705 (rank : 642)	θ value	θ > 10 (rank : 1153)
Query Neighborhood Hits	495	Target Neighborhood Hits	605	Shared Neighborhood Hits	76
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

PTN6_MOUSE
NC score	0.080684 (rank : 643)	θ value	θ > 10 (rank : 1033)
Query Neighborhood Hits	495	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

IRAK4_MOUSE
NC score	0.080646 (rank : 644)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	495	Target Neighborhood Hits	820	Shared Neighborhood Hits	86
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

FCG3B_HUMAN
NC score	0.080610 (rank : 645)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	495	Target Neighborhood Hits	67	Shared Neighborhood Hits	52
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

IRAK3_HUMAN
NC score	0.080520 (rank : 646)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	495	Target Neighborhood Hits	644	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

TEX14_MOUSE
NC score	0.080318 (rank : 647)	θ value	θ > 10 (rank : 1135)
Query Neighborhood Hits	495	Target Neighborhood Hits	1333	Shared Neighborhood Hits	92
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

A1BG_HUMAN
NC score	0.080062 (rank : 648)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	495	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

GUC2D_HUMAN
NC score	0.079998 (rank : 649)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	84
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

ANPRA_MOUSE
NC score	0.079956 (rank : 650)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	495	Target Neighborhood Hits	600	Shared Neighborhood Hits	79
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.079931 (rank : 651)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	495	Target Neighborhood Hits	612	Shared Neighborhood Hits	79
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

VASN_HUMAN
NC score	0.079196 (rank : 652)	θ value	0.47712 (rank : 400)
Query Neighborhood Hits	495	Target Neighborhood Hits	449	Shared Neighborhood Hits	64
SwissProt Accessions	Q6EMK4, Q6UXL4, Q6UXL5, Q96CX1	Gene names	VASN, SLITL2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

CD33_HUMAN
NC score	0.079040 (rank : 653)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	495	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	P20138, Q8TD24	Gene names	CD33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3) (gp67).

CNTFR_MOUSE
NC score	0.078986 (rank : 654)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	495	Target Neighborhood Hits	74	Shared Neighborhood Hits	50
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

TRIM9_HUMAN
NC score	0.078948 (rank : 655)	θ value	1.81305 (rank : 433)
Query Neighborhood Hits	495	Target Neighborhood Hits	294	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

GUC2G_MOUSE
NC score	0.078927 (rank : 656)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	495	Target Neighborhood Hits	644	Shared Neighborhood Hits	79
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

RIPK5_HUMAN
NC score	0.078808 (rank : 657)	θ value	θ > 10 (rank : 1066)
Query Neighborhood Hits	495	Target Neighborhood Hits	864	Shared Neighborhood Hits	85
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
NC score	0.078761 (rank : 658)	θ value	θ > 10 (rank : 1067)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

PTN11_HUMAN
NC score	0.078491 (rank : 659)	θ value	θ > 10 (rank : 1008)
Query Neighborhood Hits	495	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
NC score	0.078484 (rank : 660)	θ value	θ > 10 (rank : 1009)
Query Neighborhood Hits	495	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

KSR2_HUMAN
NC score	0.077634 (rank : 661)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	495	Target Neighborhood Hits	920	Shared Neighborhood Hits	86
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

ACVL1_MOUSE
NC score	0.076151 (rank : 662)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	495	Target Neighborhood Hits	739	Shared Neighborhood Hits	79
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TNI3K_MOUSE
NC score	0.076002 (rank : 663)	θ value	θ > 10 (rank : 1149)
Query Neighborhood Hits	495	Target Neighborhood Hits	1079	Shared Neighborhood Hits	86
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

FCERA_MOUSE
NC score	0.075908 (rank : 664)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	495	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FLRT3_HUMAN
NC score	0.075192 (rank : 665)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	495	Target Neighborhood Hits	281	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

TNI3K_HUMAN
NC score	0.075135 (rank : 666)	θ value	θ > 10 (rank : 1148)
Query Neighborhood Hits	495	Target Neighborhood Hits	1084	Shared Neighborhood Hits	85
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

SLIT2_HUMAN
NC score	0.075126 (rank : 667)	θ value	θ > 10 (rank : 1082)
Query Neighborhood Hits	495	Target Neighborhood Hits	708	Shared Neighborhood Hits	69
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

FLRT1_HUMAN
NC score	0.074792 (rank : 668)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	495	Target Neighborhood Hits	286	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZU1	Gene names	FLRT1
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT1 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 1).

CNTFR_HUMAN
NC score	0.074656 (rank : 669)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	495	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

ANPRB_HUMAN
NC score	0.074480 (rank : 670)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	495	Target Neighborhood Hits	646	Shared Neighborhood Hits	79
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

IGSF8_HUMAN
NC score	0.074422 (rank : 671)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	495	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

IRAK1_HUMAN
NC score	0.074137 (rank : 672)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	495	Target Neighborhood Hits	820	Shared Neighborhood Hits	85
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

SLIT2_MOUSE
NC score	0.073860 (rank : 673)	θ value	θ > 10 (rank : 1083)
Query Neighborhood Hits	495	Target Neighborhood Hits	684	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

IRAK1_MOUSE
NC score	0.073687 (rank : 674)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	495	Target Neighborhood Hits	784	Shared Neighborhood Hits	86
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

ANPRB_MOUSE
NC score	0.073589 (rank : 675)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	495	Target Neighborhood Hits	607	Shared Neighborhood Hits	79
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

IL1AP_HUMAN
NC score	0.073047 (rank : 676)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

ACVL1_HUMAN
NC score	0.072960 (rank : 677)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	495	Target Neighborhood Hits	716	Shared Neighborhood Hits	78
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

SLIT1_MOUSE
NC score	0.072959 (rank : 678)	θ value	θ > 10 (rank : 1081)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	68
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

PTN23_MOUSE
NC score	0.072769 (rank : 679)	θ value	θ > 10 (rank : 1025)
Query Neighborhood Hits	495	Target Neighborhood Hits	726	Shared Neighborhood Hits	34
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

CD33_MOUSE
NC score	0.072632 (rank : 680)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	495	Target Neighborhood Hits	45	Shared Neighborhood Hits	27
SwissProt Accessions	Q63994, Q63997	Gene names	Cd33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3).

TGFR2_HUMAN
NC score	0.071854 (rank : 681)	θ value	θ > 10 (rank : 1138)
Query Neighborhood Hits	495	Target Neighborhood Hits	748	Shared Neighborhood Hits	83
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

FCG3A_HUMAN
NC score	0.071489 (rank : 682)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	495	Target Neighborhood Hits	65	Shared Neighborhood Hits	50
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

SLIT3_HUMAN
NC score	0.071281 (rank : 683)	θ value	θ > 10 (rank : 1084)
Query Neighborhood Hits	495	Target Neighborhood Hits	682	Shared Neighborhood Hits	67
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

TMM25_HUMAN
NC score	0.071266 (rank : 684)	θ value	θ > 10 (rank : 1147)
Query Neighborhood Hits	495	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TGFR2_MOUSE
NC score	0.071073 (rank : 685)	θ value	θ > 10 (rank : 1139)
Query Neighborhood Hits	495	Target Neighborhood Hits	748	Shared Neighborhood Hits	84
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

SLIT3_MOUSE
NC score	0.071029 (rank : 686)	θ value	θ > 10 (rank : 1085)
Query Neighborhood Hits	495	Target Neighborhood Hits	700	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SLIT1_HUMAN
NC score	0.070619 (rank : 687)	θ value	θ > 10 (rank : 1080)
Query Neighborhood Hits	495	Target Neighborhood Hits	700	Shared Neighborhood Hits	67
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

PTN23_HUMAN
NC score	0.070436 (rank : 688)	θ value	θ > 10 (rank : 1024)
Query Neighborhood Hits	495	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

IKKA_HUMAN
NC score	0.070264 (rank : 689)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	495	Target Neighborhood Hits	863	Shared Neighborhood Hits	85
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

NEK11_MOUSE
NC score	0.070065 (rank : 690)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	495	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

IKKA_MOUSE
NC score	0.069887 (rank : 691)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	85
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

PTN14_HUMAN
NC score	0.069213 (rank : 692)	θ value	θ > 10 (rank : 1014)
Query Neighborhood Hits	495	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

STK24_MOUSE
NC score	0.069044 (rank : 693)	θ value	θ > 10 (rank : 1108)
Query Neighborhood Hits	495	Target Neighborhood Hits	856	Shared Neighborhood Hits	85
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

TRIM9_MOUSE
NC score	0.069029 (rank : 694)	θ value	2.36792 (rank : 438)
Query Neighborhood Hits	495	Target Neighborhood Hits	274	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

NEK11_HUMAN
NC score	0.068939 (rank : 695)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	495	Target Neighborhood Hits	1043	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STK24_HUMAN
NC score	0.068907 (rank : 696)	θ value	θ > 10 (rank : 1107)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

PTN21_MOUSE
NC score	0.068719 (rank : 697)	θ value	θ > 10 (rank : 1021)
Query Neighborhood Hits	495	Target Neighborhood Hits	155	Shared Neighborhood Hits	21
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN14_MOUSE
NC score	0.068701 (rank : 698)	θ value	θ > 10 (rank : 1015)
Query Neighborhood Hits	495	Target Neighborhood Hits	142	Shared Neighborhood Hits	20
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

RIPK3_MOUSE
NC score	0.068645 (rank : 699)	θ value	θ > 10 (rank : 1064)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

MST4_HUMAN
NC score	0.068152 (rank : 700)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

NEK7_MOUSE
NC score	0.068054 (rank : 701)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_HUMAN
NC score	0.068050 (rank : 702)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MST4_MOUSE
NC score	0.068037 (rank : 703)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

PTN21_HUMAN
NC score	0.067907 (rank : 704)	θ value	θ > 10 (rank : 1020)
Query Neighborhood Hits	495	Target Neighborhood Hits	143	Shared Neighborhood Hits	18
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

FCGR2_MOUSE
NC score	0.067751 (rank : 705)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	495	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

IGSF8_MOUSE
NC score	0.067530 (rank : 706)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	495	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

FLRT2_HUMAN
NC score	0.066985 (rank : 707)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	495	Target Neighborhood Hits	295	Shared Neighborhood Hits	54
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

PTN3_HUMAN
NC score	0.066671 (rank : 708)	θ value	θ > 10 (rank : 1028)
Query Neighborhood Hits	495	Target Neighborhood Hits	258	Shared Neighborhood Hits	26
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

SLAF8_MOUSE
NC score	0.066565 (rank : 709)	θ value	8.99809 (rank : 490)
Query Neighborhood Hits	495	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D3G2, Q8R3T7	Gene names	Slamf8, Blame
Domain Architecture	No domain graphic available
Description	SLAM family member 8 precursor (B-lymphocyte activator macrophage expressed).

TGFR1_MOUSE
NC score	0.066545 (rank : 710)	θ value	θ > 10 (rank : 1137)
Query Neighborhood Hits	495	Target Neighborhood Hits	753	Shared Neighborhood Hits	84
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

NYX_MOUSE
NC score	0.066545 (rank : 711)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	495	Target Neighborhood Hits	241	Shared Neighborhood Hits	44
SwissProt Accessions	P83503, Q8BYN4	Gene names	Nyx
Domain Architecture
Description	Nyctalopin precursor.

CHAD_HUMAN
NC score	0.066539 (rank : 712)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	44
SwissProt Accessions	O15335, Q96RJ5	Gene names	CHAD
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

YSK4_HUMAN
NC score	0.066533 (rank : 713)	θ value	θ > 10 (rank : 1181)
Query Neighborhood Hits	495	Target Neighborhood Hits	921	Shared Neighborhood Hits	88
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

MYLK2_HUMAN
NC score	0.066472 (rank : 714)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	495	Target Neighborhood Hits	920	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEK6_HUMAN
NC score	0.066364 (rank : 715)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	495	Target Neighborhood Hits	848	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.066246 (rank : 716)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

TGFR1_HUMAN
NC score	0.066183 (rank : 717)	θ value	θ > 10 (rank : 1136)
Query Neighborhood Hits	495	Target Neighborhood Hits	755	Shared Neighborhood Hits	84
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

CD226_MOUSE
NC score	0.066158 (rank : 718)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	495	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K4F0	Gene names	Cd226, Pta1
Domain Architecture
Description	CD226 antigen precursor (Platelet and T-cell activation antigen 1).

NYX_HUMAN
NC score	0.065817 (rank : 719)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	Q9GZU5, Q5H983, Q9H4J0	Gene names	NYX, CLRP
Domain Architecture
Description	Nyctalopin precursor.

NEK4_HUMAN
NC score	0.065718 (rank : 720)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	495	Target Neighborhood Hits	883	Shared Neighborhood Hits	85
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

BMR1B_MOUSE
NC score	0.065546 (rank : 721)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	495	Target Neighborhood Hits	758	Shared Neighborhood Hits	81
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

NEK4_MOUSE
NC score	0.065383 (rank : 722)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

BMR1A_HUMAN
NC score	0.065247 (rank : 723)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	495	Target Neighborhood Hits	759	Shared Neighborhood Hits	83
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

STK25_MOUSE
NC score	0.065197 (rank : 724)	θ value	θ > 10 (rank : 1110)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MP2K5_MOUSE
NC score	0.065126 (rank : 725)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

BMR1A_MOUSE
NC score	0.065032 (rank : 726)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	495	Target Neighborhood Hits	758	Shared Neighborhood Hits	83
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

ANKK1_MOUSE
NC score	0.064920 (rank : 727)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	495	Target Neighborhood Hits	1072	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

STK25_HUMAN
NC score	0.064906 (rank : 728)	θ value	θ > 10 (rank : 1109)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

CD86_MOUSE
NC score	0.064852 (rank : 729)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	P42082	Gene names	Cd86
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (Early T-cell costimulatory molecule 1) (ETC-1).

E2AK2_HUMAN
NC score	0.064769 (rank : 730)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	495	Target Neighborhood Hits	856	Shared Neighborhood Hits	84
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

ACVR1_MOUSE
NC score	0.064728 (rank : 731)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	495	Target Neighborhood Hits	768	Shared Neighborhood Hits	82
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ACV1C_HUMAN
NC score	0.064709 (rank : 732)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	495	Target Neighborhood Hits	709	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

BT3A3_HUMAN
NC score	0.064655 (rank : 733)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	495	Target Neighborhood Hits	233	Shared Neighborhood Hits	101
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

CHAD_MOUSE
NC score	0.064502 (rank : 734)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	495	Target Neighborhood Hits	260	Shared Neighborhood Hits	44
SwissProt Accessions	O55226	Gene names	Chad
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

MP2K5_HUMAN
NC score	0.064487 (rank : 735)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	86
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PTN4_HUMAN
NC score	0.064475 (rank : 736)	θ value	θ > 10 (rank : 1029)
Query Neighborhood Hits	495	Target Neighborhood Hits	303	Shared Neighborhood Hits	25
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

BMR1B_HUMAN
NC score	0.064346 (rank : 737)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	495	Target Neighborhood Hits	760	Shared Neighborhood Hits	81
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

STK4_MOUSE
NC score	0.064117 (rank : 738)	θ value	θ > 10 (rank : 1119)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

TSK_HUMAN
NC score	0.063954 (rank : 739)	θ value	θ > 10 (rank : 1157)
Query Neighborhood Hits	495	Target Neighborhood Hits	268	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

ACVR1_HUMAN
NC score	0.063948 (rank : 740)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	495	Target Neighborhood Hits	760	Shared Neighborhood Hits	82
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

BMPR2_HUMAN
NC score	0.063938 (rank : 741)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	495	Target Neighborhood Hits	736	Shared Neighborhood Hits	80
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

R4RL2_HUMAN
NC score	0.063927 (rank : 742)	θ value	θ > 10 (rank : 1053)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

R4RL2_MOUSE
NC score	0.063897 (rank : 743)	θ value	θ > 10 (rank : 1054)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

STK4_HUMAN
NC score	0.063894 (rank : 744)	θ value	θ > 10 (rank : 1118)
Query Neighborhood Hits	495	Target Neighborhood Hits	870	Shared Neighborhood Hits	85
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

LRC15_MOUSE
NC score	0.063850 (rank : 745)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	495	Target Neighborhood Hits	305	Shared Neighborhood Hits	44
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

STK3_MOUSE
NC score	0.063819 (rank : 746)	θ value	θ > 10 (rank : 1117)
Query Neighborhood Hits	495	Target Neighborhood Hits	869	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

IKKB_MOUSE
NC score	0.063696 (rank : 747)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	495	Target Neighborhood Hits	984	Shared Neighborhood Hits	86
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_HUMAN
NC score	0.063640 (rank : 748)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	495	Target Neighborhood Hits	980	Shared Neighborhood Hits	85
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

GP124_MOUSE
NC score	0.063194 (rank : 749)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	495	Target Neighborhood Hits	423	Shared Neighborhood Hits	59
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

RIPK4_HUMAN
NC score	0.063148 (rank : 750)	θ value	θ > 10 (rank : 1065)
Query Neighborhood Hits	495	Target Neighborhood Hits	1094	Shared Neighborhood Hits	87
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

STK3_HUMAN
NC score	0.063122 (rank : 751)	θ value	θ > 10 (rank : 1116)
Query Neighborhood Hits	495	Target Neighborhood Hits	861	Shared Neighborhood Hits	85
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

GP124_HUMAN
NC score	0.063078 (rank : 752)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	495	Target Neighborhood Hits	304	Shared Neighborhood Hits	54
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

ALS_HUMAN
NC score	0.062958 (rank : 753)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	495	Target Neighborhood Hits	280	Shared Neighborhood Hits	45
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

RTN4R_HUMAN
NC score	0.062958 (rank : 754)	θ value	θ > 10 (rank : 1070)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

BT3A1_HUMAN
NC score	0.062875 (rank : 755)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	96
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

ANKK1_HUMAN
NC score	0.062730 (rank : 756)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	495	Target Neighborhood Hits	1075	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

CD86_HUMAN
NC score	0.062471 (rank : 757)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	495	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	P42081, Q13655, Q7M4L5	Gene names	CD86, CD28LG2
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63).

STK36_MOUSE
NC score	0.062424 (rank : 758)	θ value	θ > 10 (rank : 1113)
Query Neighborhood Hits	495	Target Neighborhood Hits	877	Shared Neighborhood Hits	85
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

BMPR2_MOUSE
NC score	0.062374 (rank : 759)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	495	Target Neighborhood Hits	738	Shared Neighborhood Hits	80
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

STK33_HUMAN
NC score	0.062369 (rank : 760)	θ value	θ > 10 (rank : 1111)
Query Neighborhood Hits	495	Target Neighborhood Hits	879	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

DAPK3_HUMAN
NC score	0.062243 (rank : 761)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	495	Target Neighborhood Hits	945	Shared Neighborhood Hits	85
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

E2AK2_MOUSE
NC score	0.062235 (rank : 762)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	495	Target Neighborhood Hits	864	Shared Neighborhood Hits	86
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

DAPK2_MOUSE
NC score	0.062177 (rank : 763)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MAK_MOUSE
NC score	0.062071 (rank : 764)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	85
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

CPN2_HUMAN
NC score	0.062027 (rank : 765)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	45
SwissProt Accessions	P22792, Q86SU4, Q8N5V4	Gene names	CPN2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

GPV_MOUSE
NC score	0.062019 (rank : 766)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	495	Target Neighborhood Hits	293	Shared Neighborhood Hits	43
SwissProt Accessions	O08742	Gene names	Gp5
Domain Architecture	No domain graphic available
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

R4RL1_HUMAN
NC score	0.061834 (rank : 767)	θ value	θ > 10 (rank : 1051)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

DAPK2_HUMAN
NC score	0.061779 (rank : 768)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

SREC2_HUMAN
NC score	0.061651 (rank : 769)	θ value	θ > 10 (rank : 1094)
Query Neighborhood Hits	495	Target Neighborhood Hits	645	Shared Neighborhood Hits	48
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

LRC15_HUMAN
NC score	0.061641 (rank : 770)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	495	Target Neighborhood Hits	305	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

E2AK3_MOUSE
NC score	0.061548 (rank : 771)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

ALS_MOUSE
NC score	0.061517 (rank : 772)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	495	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	P70389, Q9DBI7	Gene names	Igfals, Albs, Als
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

LAMA5_MOUSE
NC score	0.061482 (rank : 773)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

MAK_HUMAN
NC score	0.061457 (rank : 774)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	84
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

DAPK3_MOUSE
NC score	0.061378 (rank : 775)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	86
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ACV1C_MOUSE
NC score	0.061338 (rank : 776)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

PTN13_MOUSE
NC score	0.061337 (rank : 777)	θ value	θ > 10 (rank : 1013)
Query Neighborhood Hits	495	Target Neighborhood Hits	426	Shared Neighborhood Hits	23
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

TPBG_HUMAN
NC score	0.061245 (rank : 778)	θ value	θ > 10 (rank : 1155)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	44
SwissProt Accessions	Q13641	Gene names	TPBG, 5T4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (5T4 oncofetal antigen) (M6P1).

ST17B_MOUSE
NC score	0.061201 (rank : 779)	θ value	θ > 10 (rank : 1102)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK36_HUMAN
NC score	0.061130 (rank : 780)	θ value	θ > 10 (rank : 1112)
Query Neighborhood Hits	495	Target Neighborhood Hits	896	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ICOSL_HUMAN
NC score	0.061101 (rank : 781)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	495	Target Neighborhood Hits	70	Shared Neighborhood Hits	46
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

ULK3_MOUSE
NC score	0.061084 (rank : 782)	θ value	θ > 10 (rank : 1175)
Query Neighborhood Hits	495	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

CPN2_MOUSE
NC score	0.060993 (rank : 783)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	495	Target Neighborhood Hits	291	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

NAGPA_MOUSE
NC score	0.060989 (rank : 784)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	495	Target Neighborhood Hits	308	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

CDK4_MOUSE
NC score	0.060911 (rank : 785)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	85
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

ICK_HUMAN
NC score	0.060849 (rank : 786)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ACV1B_MOUSE
NC score	0.060761 (rank : 787)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	495	Target Neighborhood Hits	753	Shared Neighborhood Hits	83
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ULK3_HUMAN
NC score	0.060724 (rank : 788)	θ value	θ > 10 (rank : 1174)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	85
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK1_HUMAN
NC score	0.060592 (rank : 789)	θ value	θ > 10 (rank : 1170)
Query Neighborhood Hits	495	Target Neighborhood Hits	1121	Shared Neighborhood Hits	92
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

PTN13_HUMAN
NC score	0.060563 (rank : 790)	θ value	θ > 10 (rank : 1012)
Query Neighborhood Hits	495	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

ICK_MOUSE
NC score	0.060537 (rank : 791)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

STK39_MOUSE
NC score	0.060525 (rank : 792)	θ value	θ > 10 (rank : 1115)
Query Neighborhood Hits	495	Target Neighborhood Hits	915	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

ULK2_HUMAN
NC score	0.060500 (rank : 793)	θ value	θ > 10 (rank : 1172)
Query Neighborhood Hits	495	Target Neighborhood Hits	979	Shared Neighborhood Hits	90
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

STK16_HUMAN
NC score	0.060431 (rank : 794)	θ value	θ > 10 (rank : 1105)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

OXSR1_HUMAN
NC score	0.060423 (rank : 795)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ULK2_MOUSE
NC score	0.060351 (rank : 796)	θ value	θ > 10 (rank : 1173)
Query Neighborhood Hits	495	Target Neighborhood Hits	943	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK1_MOUSE
NC score	0.060340 (rank : 797)	θ value	θ > 10 (rank : 1171)
Query Neighborhood Hits	495	Target Neighborhood Hits	1214	Shared Neighborhood Hits	96
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ACV1B_HUMAN
NC score	0.060333 (rank : 798)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	495	Target Neighborhood Hits	753	Shared Neighborhood Hits	83
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

LAMA5_HUMAN
NC score	0.060327 (rank : 799)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	495	Target Neighborhood Hits	976	Shared Neighborhood Hits	58
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

STK39_HUMAN
NC score	0.060240 (rank : 800)	θ value	θ > 10 (rank : 1114)
Query Neighborhood Hits	495	Target Neighborhood Hits	882	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

GPV_HUMAN
NC score	0.060226 (rank : 801)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	495	Target Neighborhood Hits	284	Shared Neighborhood Hits	44
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

AGRIN_HUMAN
NC score	0.060208 (rank : 802)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	495	Target Neighborhood Hits	582	Shared Neighborhood Hits	47
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

NEK3_HUMAN
NC score	0.060203 (rank : 803)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	495	Target Neighborhood Hits	865	Shared Neighborhood Hits	85
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

STK16_MOUSE
NC score	0.060176 (rank : 804)	θ value	θ > 10 (rank : 1106)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	83
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

LY9_HUMAN
NC score	0.060144 (rank : 805)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	495	Target Neighborhood Hits	82	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

CDK6_MOUSE
NC score	0.060126 (rank : 806)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

OXSR1_MOUSE
NC score	0.060068 (rank : 807)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	495	Target Neighborhood Hits	865	Shared Neighborhood Hits	85
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

KS6A3_HUMAN
NC score	0.060044 (rank : 808)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	495	Target Neighborhood Hits	859	Shared Neighborhood Hits	85
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
NC score	0.060011 (rank : 809)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

CDK6_HUMAN
NC score	0.059862 (rank : 810)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CD2L7_HUMAN
NC score	0.059818 (rank : 811)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	495	Target Neighborhood Hits	1275	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

PLK4_MOUSE
NC score	0.059804 (rank : 812)	θ value	θ > 10 (rank : 1002)
Query Neighborhood Hits	495	Target Neighborhood Hits	879	Shared Neighborhood Hits	85
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

RTN4R_MOUSE
NC score	0.059739 (rank : 813)	θ value	θ > 10 (rank : 1071)
Query Neighborhood Hits	495	Target Neighborhood Hits	293	Shared Neighborhood Hits	45
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

NEK1_MOUSE
NC score	0.059653 (rank : 814)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	495	Target Neighborhood Hits	1311	Shared Neighborhood Hits	97
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

LRTM1_MOUSE
NC score	0.059567 (rank : 815)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	495	Target Neighborhood Hits	264	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K377, Q3UVX1	Gene names	Lrrtm1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

NEK3_MOUSE
NC score	0.059544 (rank : 816)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK9_HUMAN
NC score	0.059481 (rank : 817)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	495	Target Neighborhood Hits	900	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

CDK4_HUMAN
NC score	0.059470 (rank : 818)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	85
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

PLK4_HUMAN
NC score	0.059443 (rank : 819)	θ value	θ > 10 (rank : 1001)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	88
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KS6A2_HUMAN
NC score	0.059421 (rank : 820)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	85
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

E2AK3_HUMAN
NC score	0.059386 (rank : 821)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	495	Target Neighborhood Hits	859	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

NEK1_HUMAN
NC score	0.059370 (rank : 822)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	495	Target Neighborhood Hits	1129	Shared Neighborhood Hits	88
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NUAK2_HUMAN
NC score	0.059322 (rank : 823)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

PAK6_HUMAN
NC score	0.059299 (rank : 824)	θ value	θ > 10 (rank : 966)
Query Neighborhood Hits	495	Target Neighborhood Hits	915	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

IRAK2_HUMAN
NC score	0.059283 (rank : 825)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	495	Target Neighborhood Hits	714	Shared Neighborhood Hits	69
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

KS6A1_HUMAN
NC score	0.059282 (rank : 826)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

R4RL1_MOUSE
NC score	0.059214 (rank : 827)	θ value	θ > 10 (rank : 1052)
Query Neighborhood Hits	495	Target Neighborhood Hits	235	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K0S5	Gene names	Rtn4rl1, Ngrl2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

PKD1_HUMAN
NC score	0.059202 (rank : 828)	θ value	θ > 10 (rank : 988)
Query Neighborhood Hits	495	Target Neighborhood Hits	387	Shared Neighborhood Hits	51
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

SREC_HUMAN
NC score	0.059131 (rank : 829)	θ value	θ > 10 (rank : 1096)
Query Neighborhood Hits	495	Target Neighborhood Hits	645	Shared Neighborhood Hits	43
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

KS6A2_MOUSE
NC score	0.059027 (rank : 830)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

LRC52_HUMAN
NC score	0.058988 (rank : 831)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N7C0, Q5T9K5	Gene names	LRRC52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC17_MOUSE
NC score	0.058926 (rank : 832)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	495	Target Neighborhood Hits	268	Shared Neighborhood Hits	44
SwissProt Accessions	Q9CXD9	Gene names	Lrrc17
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor.

AURKC_HUMAN
NC score	0.058777 (rank : 833)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

LRRC3_MOUSE
NC score	0.058743 (rank : 834)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	495	Target Neighborhood Hits	236	Shared Neighborhood Hits	43
SwissProt Accessions	P59034	Gene names	Lrrc3
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

LRTM4_MOUSE
NC score	0.058704 (rank : 835)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	495	Target Neighborhood Hits	284	Shared Neighborhood Hits	46
SwissProt Accessions	Q80XG9, Q8C030, Q8JZS8	Gene names	Lrrtm4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

TPBG_MOUSE
NC score	0.058664 (rank : 836)	θ value	θ > 10 (rank : 1156)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z0L0, Q6PE98, Q8BQA4	Gene names	Tpbg, 5t4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein).

PKN1_MOUSE
NC score	0.058569 (rank : 837)	θ value	θ > 10 (rank : 990)
Query Neighborhood Hits	495	Target Neighborhood Hits	888	Shared Neighborhood Hits	85
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

AMHR2_HUMAN
NC score	0.058470 (rank : 838)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	495	Target Neighborhood Hits	715	Shared Neighborhood Hits	80
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

NEK9_MOUSE
NC score	0.058465 (rank : 839)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	495	Target Neighborhood Hits	890	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

LRTM2_HUMAN
NC score	0.058460 (rank : 840)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	495	Target Neighborhood Hits	282	Shared Neighborhood Hits	44
SwissProt Accessions	O43300, Q7L770	Gene names	LRRTM2, KIAA0416, LRRN2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor (Leucine-rich repeat neuronal 2 protein).

LRTM1_HUMAN
NC score	0.058434 (rank : 841)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	495	Target Neighborhood Hits	273	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UE6, Q96DN1	Gene names	LRRTM1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

LRTM2_MOUSE
NC score	0.058411 (rank : 842)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGA3, Q80U08	Gene names	Lrrtm2, Kiaa0416
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor.

CD2L5_MOUSE
NC score	0.058402 (rank : 843)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	495	Target Neighborhood Hits	1011	Shared Neighborhood Hits	90
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L5_HUMAN
NC score	0.058375 (rank : 844)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	495	Target Neighborhood Hits	987	Shared Neighborhood Hits	88
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

LRC52_MOUSE
NC score	0.058329 (rank : 845)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	495	Target Neighborhood Hits	240	Shared Neighborhood Hits	44
SwissProt Accessions	Q5M8M9	Gene names	Lrrc52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

PKN1_HUMAN
NC score	0.058322 (rank : 846)	θ value	θ > 10 (rank : 989)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	85
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

M3K15_HUMAN
NC score	0.058297 (rank : 847)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	495	Target Neighborhood Hits	914	Shared Neighborhood Hits	86
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

NEK2_HUMAN
NC score	0.058271 (rank : 848)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	495	Target Neighborhood Hits	908	Shared Neighborhood Hits	87
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

LGI4_HUMAN
NC score	0.058247 (rank : 849)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	495	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N135	Gene names	LGI4, LGIL3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

LRTM4_HUMAN
NC score	0.058197 (rank : 850)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

ST17A_HUMAN
NC score	0.058189 (rank : 851)	θ value	θ > 10 (rank : 1100)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

AVR2A_MOUSE
NC score	0.058177 (rank : 852)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	495	Target Neighborhood Hits	767	Shared Neighborhood Hits	81
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.058176 (rank : 853)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	495	Target Neighborhood Hits	767	Shared Neighborhood Hits	81
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

ASPN_MOUSE
NC score	0.058165 (rank : 854)	θ value	5.27518 (rank : 455)
Query Neighborhood Hits	495	Target Neighborhood Hits	277	Shared Neighborhood Hits	45
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

M3K5_MOUSE
NC score	0.058146 (rank : 855)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	85
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

KS6A6_HUMAN
NC score	0.058061 (rank : 856)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

NAGPA_HUMAN
NC score	0.057996 (rank : 857)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	495	Target Neighborhood Hits	282	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

M3K5_HUMAN
NC score	0.057948 (rank : 858)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	495	Target Neighborhood Hits	868	Shared Neighborhood Hits	85
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

LRC55_MOUSE
NC score	0.057934 (rank : 859)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	495	Target Neighborhood Hits	254	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UY51	Gene names	Lrrc55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

PAK7_HUMAN
NC score	0.057929 (rank : 860)	θ value	θ > 10 (rank : 967)
Query Neighborhood Hits	495	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

AURKC_MOUSE
NC score	0.057868 (rank : 861)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	495	Target Neighborhood Hits	844	Shared Neighborhood Hits	85
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

NUAK1_HUMAN
NC score	0.057845 (rank : 862)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

CRLF2_MOUSE
NC score	0.057824 (rank : 863)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	495	Target Neighborhood Hits	39	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

MEGF9_HUMAN
NC score	0.057726 (rank : 864)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	495	Target Neighborhood Hits	557	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

SREC2_MOUSE
NC score	0.057710 (rank : 865)	θ value	θ > 10 (rank : 1095)
Query Neighborhood Hits	495	Target Neighborhood Hits	605	Shared Neighborhood Hits	41
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

AAPK1_HUMAN
NC score	0.057691 (rank : 866)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

M3K1_MOUSE
NC score	0.057626 (rank : 867)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	495	Target Neighborhood Hits	952	Shared Neighborhood Hits	89
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

NUAK2_MOUSE
NC score	0.057571 (rank : 868)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	495	Target Neighborhood Hits	878	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PAK7_MOUSE
NC score	0.057537 (rank : 869)	θ value	θ > 10 (rank : 968)
Query Neighborhood Hits	495	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

AURKB_HUMAN
NC score	0.057530 (rank : 870)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

LRC55_HUMAN
NC score	0.057495 (rank : 871)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	495	Target Neighborhood Hits	257	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZSA7	Gene names	LRRC55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

NUAK1_MOUSE
NC score	0.057495 (rank : 872)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	495	Target Neighborhood Hits	881	Shared Neighborhood Hits	85
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

TRI42_HUMAN
NC score	0.057456 (rank : 873)	θ value	8.99809 (rank : 492)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

GP1BA_HUMAN
NC score	0.057450 (rank : 874)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	495	Target Neighborhood Hits	407	Shared Neighborhood Hits	47
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

AAPK1_MOUSE
NC score	0.057426 (rank : 875)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

ST17B_HUMAN
NC score	0.057411 (rank : 876)	θ value	θ > 10 (rank : 1101)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	81
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

SN1L2_HUMAN
NC score	0.057319 (rank : 877)	θ value	θ > 10 (rank : 1090)
Query Neighborhood Hits	495	Target Neighborhood Hits	964	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

GPIX_HUMAN
NC score	0.057305 (rank : 878)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	495	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	P14770, Q14445, Q92525	Gene names	GP9
Domain Architecture
Description	Platelet glycoprotein IX precursor (GPIX) (CD42a antigen).

LRTM3_HUMAN
NC score	0.057261 (rank : 879)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	44
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

PLK2_MOUSE
NC score	0.057172 (rank : 880)	θ value	θ > 10 (rank : 998)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

KR171_HUMAN
NC score	0.057138 (rank : 881)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	495	Target Neighborhood Hits	144	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

TSK_MOUSE
NC score	0.057122 (rank : 882)	θ value	θ > 10 (rank : 1158)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

LRC19_MOUSE
NC score	0.057072 (rank : 883)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	495	Target Neighborhood Hits	238	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZT5, Q6P8J1	Gene names	Lrrc19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

A2GL_HUMAN
NC score	0.057063 (rank : 884)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	495	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	P02750, Q8N4F5, Q96QZ4	Gene names	LRG1, LRG
Domain Architecture
Description	Leucine-rich alpha-2-glycoprotein precursor (LRG).

PLK2_HUMAN
NC score	0.057022 (rank : 885)	θ value	θ > 10 (rank : 997)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

SLK_HUMAN
NC score	0.057016 (rank : 886)	θ value	θ > 10 (rank : 1086)
Query Neighborhood Hits	495	Target Neighborhood Hits	1775	Shared Neighborhood Hits	95
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SN1L2_MOUSE
NC score	0.056996 (rank : 887)	θ value	θ > 10 (rank : 1091)
Query Neighborhood Hits	495	Target Neighborhood Hits	944	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

UHMK1_MOUSE
NC score	0.056987 (rank : 888)	θ value	θ > 10 (rank : 1169)
Query Neighborhood Hits	495	Target Neighborhood Hits	809	Shared Neighborhood Hits	77
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

NEK8_HUMAN
NC score	0.056892 (rank : 889)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	495	Target Neighborhood Hits	872	Shared Neighborhood Hits	85
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
NC score	0.056892 (rank : 890)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	495	Target Neighborhood Hits	872	Shared Neighborhood Hits	86
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

KRA51_HUMAN
NC score	0.056872 (rank : 891)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	495	Target Neighborhood Hits	288	Shared Neighborhood Hits	21
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

PLK1_HUMAN
NC score	0.056869 (rank : 892)	θ value	θ > 10 (rank : 995)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

CDK3_HUMAN
NC score	0.056770 (rank : 893)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	84
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

LRTM3_MOUSE
NC score	0.056645 (rank : 894)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	495	Target Neighborhood Hits	290	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

PLK3_MOUSE
NC score	0.056613 (rank : 895)	θ value	θ > 10 (rank : 1000)
Query Neighborhood Hits	495	Target Neighborhood Hits	863	Shared Neighborhood Hits	85
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

ASPN_HUMAN
NC score	0.056609 (rank : 896)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	495	Target Neighborhood Hits	274	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BXN1, Q96K79, Q96LD0, Q9NXP3	Gene names	ASPN, PLAP1
Domain Architecture
Description	Asporin precursor (Periodontal ligament-associated protein 1) (PLAP- 1).

STK6_HUMAN
NC score	0.056583 (rank : 897)	θ value	θ > 10 (rank : 1120)
Query Neighborhood Hits	495	Target Neighborhood Hits	916	Shared Neighborhood Hits	87
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

PAK4_MOUSE
NC score	0.056512 (rank : 898)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	495	Target Neighborhood Hits	1098	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

SN1L1_MOUSE
NC score	0.056510 (rank : 899)	θ value	θ > 10 (rank : 1089)
Query Neighborhood Hits	495	Target Neighborhood Hits	895	Shared Neighborhood Hits	86
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

KS6A1_MOUSE
NC score	0.056505 (rank : 900)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

SLK_MOUSE
NC score	0.056469 (rank : 901)	θ value	θ > 10 (rank : 1087)
Query Neighborhood Hits	495	Target Neighborhood Hits	1798	Shared Neighborhood Hits	93
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

LRC32_HUMAN
NC score	0.056380 (rank : 902)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	495	Target Neighborhood Hits	303	Shared Neighborhood Hits	44
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

UHMK1_HUMAN
NC score	0.056374 (rank : 903)	θ value	θ > 10 (rank : 1168)
Query Neighborhood Hits	495	Target Neighborhood Hits	808	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

MK07_MOUSE
NC score	0.056313 (rank : 904)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	495	Target Neighborhood Hits	1054	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

PKN3_MOUSE
NC score	0.056305 (rank : 905)	θ value	θ > 10 (rank : 994)
Query Neighborhood Hits	495	Target Neighborhood Hits	1009	Shared Neighborhood Hits	88
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

CDK7_MOUSE
NC score	0.056122 (rank : 906)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	85
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

E2AK1_HUMAN
NC score	0.056053 (rank : 907)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

SLAF9_MOUSE
NC score	0.055923 (rank : 908)	θ value	θ > 10 (rank : 1079)
Query Neighborhood Hits	495	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D780, Q8BTK0, Q8VE93	Gene names	Slamf9
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor.

MARK2_HUMAN
NC score	0.055885 (rank : 909)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	495	Target Neighborhood Hits	1056	Shared Neighborhood Hits	95
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

E2AK1_MOUSE
NC score	0.055870 (rank : 910)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	495	Target Neighborhood Hits	821	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

PGS1_MOUSE
NC score	0.055842 (rank : 911)	θ value	θ > 10 (rank : 983)
Query Neighborhood Hits	495	Target Neighborhood Hits	265	Shared Neighborhood Hits	43
SwissProt Accessions	P28653, Q61355	Gene names	Bgn
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

MK07_HUMAN
NC score	0.055792 (rank : 912)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	495	Target Neighborhood Hits	1087	Shared Neighborhood Hits	96
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MARK1_HUMAN
NC score	0.055770 (rank : 913)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	495	Target Neighborhood Hits	887	Shared Neighborhood Hits	88
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

PGS1_HUMAN
NC score	0.055751 (rank : 914)	θ value	θ > 10 (rank : 982)
Query Neighborhood Hits	495	Target Neighborhood Hits	261	Shared Neighborhood Hits	43
SwissProt Accessions	P21810, P13247	Gene names	BGN
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

MARK3_HUMAN
NC score	0.055735 (rank : 915)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	87
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

CDK7_HUMAN
NC score	0.055693 (rank : 916)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

PLK3_HUMAN
NC score	0.055638 (rank : 917)	θ value	θ > 10 (rank : 999)
Query Neighborhood Hits	495	Target Neighborhood Hits	865	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PINK1_MOUSE
NC score	0.055622 (rank : 918)	θ value	θ > 10 (rank : 987)
Query Neighborhood Hits	495	Target Neighborhood Hits	726	Shared Neighborhood Hits	78
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

CD180_MOUSE
NC score	0.055615 (rank : 919)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	42
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

STK6_MOUSE
NC score	0.055603 (rank : 920)	θ value	θ > 10 (rank : 1121)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	86
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

AURKB_MOUSE
NC score	0.055575 (rank : 921)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AAPK2_HUMAN
NC score	0.055565 (rank : 922)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

MEGF9_MOUSE
NC score	0.055521 (rank : 923)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	495	Target Neighborhood Hits	896	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

CDKL2_HUMAN
NC score	0.055519 (rank : 924)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

FCGR3_MOUSE
NC score	0.055461 (rank : 925)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	495	Target Neighborhood Hits	98	Shared Neighborhood Hits	45
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

FCN1_MOUSE
NC score	0.055445 (rank : 926)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	495	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

PAK4_HUMAN
NC score	0.055444 (rank : 927)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	495	Target Neighborhood Hits	924	Shared Neighborhood Hits	89
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MINK1_HUMAN
NC score	0.055439 (rank : 928)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	495	Target Neighborhood Hits	1477	Shared Neighborhood Hits	92
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

SN1L1_HUMAN
NC score	0.055421 (rank : 929)	θ value	θ > 10 (rank : 1088)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	88
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

IL18R_MOUSE
NC score	0.055390 (rank : 930)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	495	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

PKN2_HUMAN
NC score	0.055377 (rank : 931)	θ value	θ > 10 (rank : 991)
Query Neighborhood Hits	495	Target Neighborhood Hits	892	Shared Neighborhood Hits	85
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

M3K6_HUMAN
NC score	0.055375 (rank : 932)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	495	Target Neighborhood Hits	889	Shared Neighborhood Hits	88
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

MINK1_MOUSE
NC score	0.055365 (rank : 933)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	495	Target Neighborhood Hits	1451	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MARK1_MOUSE
NC score	0.055342 (rank : 934)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

CDK2_MOUSE
NC score	0.055311 (rank : 935)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	85
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDC2_HUMAN
NC score	0.055300 (rank : 936)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	84
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

LRC17_HUMAN
NC score	0.055298 (rank : 937)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	495	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

CDK2_HUMAN
NC score	0.055278 (rank : 938)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

LGI4_MOUSE
NC score	0.055278 (rank : 939)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	495	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1S1, Q8K4Y8	Gene names	Lgi4, Lgil3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

NRK_HUMAN
NC score	0.055266 (rank : 940)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	495	Target Neighborhood Hits	931	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

TLR5_HUMAN
NC score	0.055250 (rank : 941)	θ value	θ > 10 (rank : 1144)
Query Neighborhood Hits	495	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

MP2K7_HUMAN
NC score	0.055238 (rank : 942)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	84
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

CDC2_MOUSE
NC score	0.055231 (rank : 943)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

PKN3_HUMAN
NC score	0.055203 (rank : 944)	θ value	θ > 10 (rank : 993)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	90
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

STK11_HUMAN
NC score	0.055157 (rank : 945)	θ value	θ > 10 (rank : 1104)
Query Neighborhood Hits	495	Target Neighborhood Hits	831	Shared Neighborhood Hits	84
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

NEK2_MOUSE
NC score	0.055148 (rank : 946)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	495	Target Neighborhood Hits	876	Shared Neighborhood Hits	85
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

PKN2_MOUSE
NC score	0.055139 (rank : 947)	θ value	θ > 10 (rank : 992)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

TLR13_MOUSE
NC score	0.055130 (rank : 948)	θ value	θ > 10 (rank : 1141)
Query Neighborhood Hits	495	Target Neighborhood Hits	335	Shared Neighborhood Hits	53
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

LGI2_HUMAN
NC score	0.055088 (rank : 949)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	495	Target Neighborhood Hits	232	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N0V4, Q8NDW6, Q96PX2, Q9NVK4	Gene names	LGI2, KIAA1916, LGIL2
Domain Architecture
Description	Leucine-rich repeat LGI family member 2 precursor (Leucine-rich glioma-inactivated protein 2) (LGI1-like protein 2).

LGI1_MOUSE
NC score	0.055087 (rank : 950)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JIA1	Gene names	Lgi1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor.

NLK_HUMAN
NC score	0.055033 (rank : 951)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
NC score	0.055025 (rank : 952)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	86
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

MP2K6_HUMAN
NC score	0.054983 (rank : 953)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NIM1_HUMAN
NC score	0.054974 (rank : 954)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	86
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TAOK2_HUMAN
NC score	0.054899 (rank : 955)	θ value	θ > 10 (rank : 1124)
Query Neighborhood Hits	495	Target Neighborhood Hits	1172	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

KPSH2_HUMAN
NC score	0.054853 (rank : 956)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	85
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

MARK3_MOUSE
NC score	0.054837 (rank : 957)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	495	Target Neighborhood Hits	919	Shared Neighborhood Hits	85
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

M4K4_MOUSE
NC score	0.054831 (rank : 958)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	495	Target Neighborhood Hits	1560	Shared Neighborhood Hits	87
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

LGI1_HUMAN
NC score	0.054818 (rank : 959)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	495	Target Neighborhood Hits	239	Shared Neighborhood Hits	44
SwissProt Accessions	O95970, Q5W001, Q5W002, Q8NI23, Q96LF5	Gene names	LGI1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor (Epitempin-1).

KCC1A_HUMAN
NC score	0.054813 (rank : 960)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

MP2K4_MOUSE
NC score	0.054788 (rank : 961)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

IKKE_MOUSE
NC score	0.054786 (rank : 962)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	495	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MP2K4_HUMAN
NC score	0.054764 (rank : 963)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

IKKE_HUMAN
NC score	0.054754 (rank : 964)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	82
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KCC1A_MOUSE
NC score	0.054746 (rank : 965)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	495	Target Neighborhood Hits	845	Shared Neighborhood Hits	85
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

LGI3_HUMAN
NC score	0.054681 (rank : 966)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	495	Target Neighborhood Hits	228	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N145, Q86TL4, Q8N296	Gene names	LGI3, LGIL4
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (LGI1-like protein 4).

KPCD_HUMAN
NC score	0.054640 (rank : 967)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	495	Target Neighborhood Hits	900	Shared Neighborhood Hits	86
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

PGS2_MOUSE
NC score	0.054625 (rank : 968)	θ value	θ > 10 (rank : 985)
Query Neighborhood Hits	495	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

CDKL4_MOUSE
NC score	0.054369 (rank : 969)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	495	Target Neighborhood Hits	833	Shared Neighborhood Hits	83
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

PLK1_MOUSE
NC score	0.054355 (rank : 970)	θ value	θ > 10 (rank : 996)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

LRC19_HUMAN
NC score	0.054338 (rank : 971)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	495	Target Neighborhood Hits	217	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H756	Gene names	LRRC19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

GP1BB_MOUSE
NC score	0.054301 (rank : 972)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	495	Target Neighborhood Hits	136	Shared Neighborhood Hits	38
SwissProt Accessions	P56400	Gene names	Gp1bb
Domain Architecture
Description	Platelet glycoprotein Ib beta chain precursor (GP-Ib beta) (GPIbB) (GPIb-beta) (CD42c antigen).

MARK2_MOUSE
NC score	0.054287 (rank : 973)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	495	Target Neighborhood Hits	1018	Shared Neighborhood Hits	92
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MP2K6_MOUSE
NC score	0.054269 (rank : 974)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

M4K1_HUMAN
NC score	0.054249 (rank : 975)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	85
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
NC score	0.054240 (rank : 976)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	87
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

FCN1_HUMAN
NC score	0.054184 (rank : 977)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	495	Target Neighborhood Hits	147	Shared Neighborhood Hits	13
SwissProt Accessions	O00602, Q92596	Gene names	FCN1
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

LR37B_HUMAN
NC score	0.054169 (rank : 978)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	495	Target Neighborhood Hits	392	Shared Neighborhood Hits	47
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

DAPK1_HUMAN
NC score	0.054146 (rank : 979)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	495	Target Neighborhood Hits	1130	Shared Neighborhood Hits	95
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

CDK5_MOUSE
NC score	0.054138 (rank : 980)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	82
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

PAK1_HUMAN
NC score	0.054130 (rank : 981)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	495	Target Neighborhood Hits	873	Shared Neighborhood Hits	88
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK2_MOUSE
NC score	0.054110 (rank : 982)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

LRC33_HUMAN
NC score	0.054080 (rank : 983)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	495	Target Neighborhood Hits	293	Shared Neighborhood Hits	42
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

KKCC2_HUMAN
NC score	0.054052 (rank : 984)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	87
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

CDK5_HUMAN
NC score	0.054043 (rank : 985)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	82
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

PAK2_HUMAN
NC score	0.053997 (rank : 986)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	495	Target Neighborhood Hits	862	Shared Neighborhood Hits	86
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK1_MOUSE
NC score	0.053965 (rank : 987)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	495	Target Neighborhood Hits	878	Shared Neighborhood Hits	88
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

MP2K3_HUMAN
NC score	0.053949 (rank : 988)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	495	Target Neighborhood Hits	825	Shared Neighborhood Hits	84
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MK01_MOUSE
NC score	0.053938 (rank : 989)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	85
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_HUMAN
NC score	0.053902 (rank : 990)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	85
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

KKCC2_MOUSE
NC score	0.053899 (rank : 991)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	495	Target Neighborhood Hits	855	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

PCTK2_MOUSE
NC score	0.053893 (rank : 992)	θ value	θ > 10 (rank : 972)
Query Neighborhood Hits	495	Target Neighborhood Hits	836	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

CD180_HUMAN
NC score	0.053870 (rank : 993)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	495	Target Neighborhood Hits	279	Shared Neighborhood Hits	41
SwissProt Accessions	Q99467	Gene names	CD180, LY64, RP105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 64) (Radioprotective 105 kDa protein).

TNIK_HUMAN
NC score	0.053834 (rank : 994)	θ value	θ > 10 (rank : 1150)
Query Neighborhood Hits	495	Target Neighborhood Hits	1570	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TLR3_MOUSE
NC score	0.053806 (rank : 995)	θ value	θ > 10 (rank : 1143)
Query Neighborhood Hits	495	Target Neighborhood Hits	298	Shared Neighborhood Hits	46
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

PCTK2_HUMAN
NC score	0.053790 (rank : 996)	θ value	θ > 10 (rank : 971)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	83
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

DAPK1_MOUSE
NC score	0.053770 (rank : 997)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	495	Target Neighborhood Hits	1138	Shared Neighborhood Hits	95
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

K0999_MOUSE
NC score	0.053759 (rank : 998)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	495	Target Neighborhood Hits	931	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

LR37A_HUMAN
NC score	0.053750 (rank : 999)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	495	Target Neighborhood Hits	720	Shared Neighborhood Hits	58
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

KPCD_MOUSE
NC score	0.053744 (rank : 1000)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	495	Target Neighborhood Hits	888	Shared Neighborhood Hits	86
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

CDKL2_MOUSE
NC score	0.053661 (rank : 1001)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	495	Target Neighborhood Hits	854	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

K0999_HUMAN
NC score	0.053647 (rank : 1002)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

LGI3_MOUSE
NC score	0.053607 (rank : 1003)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	495	Target Neighborhood Hits	229	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

CEA19_HUMAN
NC score	0.053590 (rank : 1004)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	495	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

CD79B_MOUSE
NC score	0.053558 (rank : 1005)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	495	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

TIMD1_HUMAN
NC score	0.053537 (rank : 1006)	θ value	θ > 10 (rank : 1140)
Query Neighborhood Hits	495	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

PGS2_HUMAN
NC score	0.053521 (rank : 1007)	θ value	θ > 10 (rank : 984)
Query Neighborhood Hits	495	Target Neighborhood Hits	271	Shared Neighborhood Hits	43
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

MK03_HUMAN
NC score	0.053514 (rank : 1008)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	84
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MARK4_HUMAN
NC score	0.053507 (rank : 1009)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	495	Target Neighborhood Hits	886	Shared Neighborhood Hits	86
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

PDPK1_MOUSE
NC score	0.053470 (rank : 1010)	θ value	θ > 10 (rank : 979)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PCTK1_MOUSE
NC score	0.053469 (rank : 1011)	θ value	θ > 10 (rank : 970)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

MARK4_MOUSE
NC score	0.053462 (rank : 1012)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	495	Target Neighborhood Hits	898	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

LGR5_HUMAN
NC score	0.053435 (rank : 1013)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	495	Target Neighborhood Hits	452	Shared Neighborhood Hits	44
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

WIF1_HUMAN
NC score	0.053420 (rank : 1014)	θ value	θ > 10 (rank : 1177)
Query Neighborhood Hits	495	Target Neighborhood Hits	392	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

M3K8_HUMAN
NC score	0.053414 (rank : 1015)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	495	Target Neighborhood Hits	807	Shared Neighborhood Hits	78
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

LRRC3_HUMAN
NC score	0.053337 (rank : 1016)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	495	Target Neighborhood Hits	232	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BY71	Gene names	LRRC3, C21orf102
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

PDPK1_HUMAN
NC score	0.053258 (rank : 1017)	θ value	θ > 10 (rank : 978)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

STK10_HUMAN
NC score	0.053255 (rank : 1018)	θ value	θ > 10 (rank : 1103)
Query Neighborhood Hits	495	Target Neighborhood Hits	1921	Shared Neighborhood Hits	93
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TSSK6_MOUSE
NC score	0.053237 (rank : 1019)	θ value	θ > 10 (rank : 1163)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	85
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

KPCT_HUMAN
NC score	0.053201 (rank : 1020)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	495	Target Neighborhood Hits	897	Shared Neighborhood Hits	86
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MP2K2_HUMAN
NC score	0.053191 (rank : 1021)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

TSSK6_HUMAN
NC score	0.053187 (rank : 1022)	θ value	θ > 10 (rank : 1162)
Query Neighborhood Hits	495	Target Neighborhood Hits	824	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

MK03_MOUSE
NC score	0.053185 (rank : 1023)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

M3K3_HUMAN
NC score	0.053174 (rank : 1024)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	495	Target Neighborhood Hits	885	Shared Neighborhood Hits	86
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

TLR3_HUMAN
NC score	0.053142 (rank : 1025)	θ value	θ > 10 (rank : 1142)
Query Neighborhood Hits	495	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

PCTK1_HUMAN
NC score	0.053080 (rank : 1026)	θ value	θ > 10 (rank : 969)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	84
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

M3K3_MOUSE
NC score	0.053041 (rank : 1027)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	495	Target Neighborhood Hits	876	Shared Neighborhood Hits	86
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MP2K1_HUMAN
NC score	0.052995 (rank : 1028)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	84
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.052946 (rank : 1029)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	84
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

TAOK2_MOUSE
NC score	0.052886 (rank : 1030)	θ value	θ > 10 (rank : 1125)
Query Neighborhood Hits	495	Target Neighborhood Hits	1373	Shared Neighborhood Hits	90
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

NIM1_MOUSE
NC score	0.052830 (rank : 1031)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

MP2K3_MOUSE
NC score	0.052822 (rank : 1032)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	84
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MEGF6_HUMAN
NC score	0.052817 (rank : 1033)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	495	Target Neighborhood Hits	671	Shared Neighborhood Hits	56
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

MK04_HUMAN
NC score	0.052784 (rank : 1034)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	495	Target Neighborhood Hits	837	Shared Neighborhood Hits	81
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

LGR5_MOUSE
NC score	0.052717 (rank : 1035)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	495	Target Neighborhood Hits	484	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1P4	Gene names	Lgr5, Fex, Gpr49
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX).

WIF1_MOUSE
NC score	0.052678 (rank : 1036)	θ value	θ > 10 (rank : 1178)
Query Neighborhood Hits	495	Target Neighborhood Hits	393	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

PAK3_MOUSE
NC score	0.052643 (rank : 1037)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

TLR5_MOUSE
NC score	0.052613 (rank : 1038)	θ value	θ > 10 (rank : 1145)
Query Neighborhood Hits	495	Target Neighborhood Hits	287	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

KPCT_MOUSE
NC score	0.052587 (rank : 1039)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	495	Target Neighborhood Hits	895	Shared Neighborhood Hits	86
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

PAK3_HUMAN
NC score	0.052546 (rank : 1040)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	495	Target Neighborhood Hits	887	Shared Neighborhood Hits	85
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

MELK_MOUSE
NC score	0.052532 (rank : 1041)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	495	Target Neighborhood Hits	860	Shared Neighborhood Hits	85
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

SSPO_MOUSE
NC score	0.052480 (rank : 1042)	θ value	θ > 10 (rank : 1099)
Query Neighborhood Hits	495	Target Neighborhood Hits	800	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

PCTK3_MOUSE
NC score	0.052460 (rank : 1043)	θ value	θ > 10 (rank : 974)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	82
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

GRK4_MOUSE
NC score	0.052440 (rank : 1044)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	495	Target Neighborhood Hits	808	Shared Neighborhood Hits	85
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

SLAF5_MOUSE
NC score	0.052408 (rank : 1045)	θ value	θ > 10 (rank : 1078)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	51
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

TSSK1_MOUSE
NC score	0.052405 (rank : 1046)	θ value	θ > 10 (rank : 1159)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	83
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

LGR4_HUMAN
NC score	0.052370 (rank : 1047)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	495	Target Neighborhood Hits	481	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

CI096_HUMAN
NC score	0.052252 (rank : 1048)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	495	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

MP2K2_MOUSE
NC score	0.052193 (rank : 1049)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	84
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

LGR6_HUMAN
NC score	0.052187 (rank : 1050)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	495	Target Neighborhood Hits	344	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

AL2S2_MOUSE
NC score	0.052185 (rank : 1051)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	495	Target Neighborhood Hits	709	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

CDKL3_HUMAN
NC score	0.052159 (rank : 1052)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	495	Target Neighborhood Hits	853	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

PRKY_HUMAN
NC score	0.052101 (rank : 1053)	θ value	θ > 10 (rank : 1005)
Query Neighborhood Hits	495	Target Neighborhood Hits	844	Shared Neighborhood Hits	85
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PINK1_HUMAN
NC score	0.052094 (rank : 1054)	θ value	θ > 10 (rank : 986)
Query Neighborhood Hits	495	Target Neighborhood Hits	741	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

FCN2_HUMAN
NC score	0.052081 (rank : 1055)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	495	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q15485, Q9UC57	Gene names	FCN2
Domain Architecture
Description	Ficolin-2 precursor (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin B) (Serum lectin p35) (EBP-37) (Hucolin) (L- Ficolin).

MK15_HUMAN
NC score	0.051959 (rank : 1056)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	495	Target Neighborhood Hits	1038	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

CDK3_MOUSE
NC score	0.051917 (rank : 1057)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	495	Target Neighborhood Hits	829	Shared Neighborhood Hits	84
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

FCN3_HUMAN
NC score	0.051905 (rank : 1058)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	495	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	O75636, Q6IBJ5, Q8WW86	Gene names	FCN3, HAKA1
Domain Architecture
Description	Ficolin-3 precursor (Collagen/fibrinogen domain-containing protein 3) (Collagen/fibrinogen domain-containing lectin 3 p35) (Hakata antigen).

RXFP2_MOUSE
NC score	0.051879 (rank : 1059)	θ value	θ > 10 (rank : 1073)
Query Neighborhood Hits	495	Target Neighborhood Hits	760	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

PCTK3_HUMAN
NC score	0.051876 (rank : 1060)	θ value	θ > 10 (rank : 973)
Query Neighborhood Hits	495	Target Neighborhood Hits	827	Shared Neighborhood Hits	82
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

MELK_HUMAN
NC score	0.051859 (rank : 1061)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	85
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

PFTK1_HUMAN
NC score	0.051840 (rank : 1062)	θ value	θ > 10 (rank : 980)
Query Neighborhood Hits	495	Target Neighborhood Hits	834	Shared Neighborhood Hits	85
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KCC1G_HUMAN
NC score	0.051837 (rank : 1063)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	495	Target Neighborhood Hits	850	Shared Neighborhood Hits	85
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
NC score	0.051828 (rank : 1064)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	495	Target Neighborhood Hits	851	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

AL2S7_HUMAN
NC score	0.051779 (rank : 1065)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	495	Target Neighborhood Hits	831	Shared Neighborhood Hits	84
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

MK04_MOUSE
NC score	0.051750 (rank : 1066)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	495	Target Neighborhood Hits	852	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

PFTK1_MOUSE
NC score	0.051742 (rank : 1067)	θ value	θ > 10 (rank : 981)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	85
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

M3K4_HUMAN
NC score	0.051732 (rank : 1068)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	495	Target Neighborhood Hits	911	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

KCC1B_MOUSE
NC score	0.051692 (rank : 1069)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

CDK9_HUMAN
NC score	0.051669 (rank : 1070)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	85
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDKL3_MOUSE
NC score	0.051668 (rank : 1071)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
NC score	0.051640 (rank : 1072)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	495	Target Neighborhood Hits	828	Shared Neighborhood Hits	83
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

NRK_MOUSE
NC score	0.051628 (rank : 1073)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	495	Target Neighborhood Hits	899	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

SCYL2_MOUSE
NC score	0.051604 (rank : 1074)	θ value	θ > 10 (rank : 1076)
Query Neighborhood Hits	495	Target Neighborhood Hits	603	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

DCAK1_HUMAN
NC score	0.051591 (rank : 1075)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	495	Target Neighborhood Hits	877	Shared Neighborhood Hits	87
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KPSH1_MOUSE
NC score	0.051537 (rank : 1076)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	85
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

M3K8_MOUSE
NC score	0.051537 (rank : 1077)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	495	Target Neighborhood Hits	815	Shared Neighborhood Hits	78
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

KCC1B_HUMAN
NC score	0.051484 (rank : 1078)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

DCAK1_MOUSE
NC score	0.051458 (rank : 1079)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	495	Target Neighborhood Hits	867	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KPSH1_HUMAN
NC score	0.051446 (rank : 1080)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	495	Target Neighborhood Hits	842	Shared Neighborhood Hits	85
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

LRC33_MOUSE
NC score	0.051416 (rank : 1081)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	495	Target Neighborhood Hits	296	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

HUNK_HUMAN
NC score	0.051374 (rank : 1082)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	495	Target Neighborhood Hits	884	Shared Neighborhood Hits	85
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

CDK9_MOUSE
NC score	0.051355 (rank : 1083)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	85
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

M4K3_HUMAN
NC score	0.051270 (rank : 1084)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	495	Target Neighborhood Hits	857	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

LRC3B_MOUSE
NC score	0.051218 (rank : 1085)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	495	Target Neighborhood Hits	215	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VCH9	Gene names	Lrrc3b, Lrp15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

TSSK4_MOUSE
NC score	0.051197 (rank : 1086)	θ value	θ > 10 (rank : 1161)
Query Neighborhood Hits	495	Target Neighborhood Hits	840	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

KKCC1_HUMAN
NC score	0.051161 (rank : 1087)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	495	Target Neighborhood Hits	858	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KPCA_MOUSE
NC score	0.051151 (rank : 1088)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	495	Target Neighborhood Hits	1067	Shared Neighborhood Hits	88
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

HUNK_MOUSE
NC score	0.051142 (rank : 1089)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	495	Target Neighborhood Hits	874	Shared Neighborhood Hits	85
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

LRC3B_HUMAN
NC score	0.051135 (rank : 1090)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	495	Target Neighborhood Hits	215	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PB8	Gene names	LRRC3B, LRP15
Domain Architecture
Description	Leucine-rich repeat-containing protein 3B precursor (Leucine-rich repeat protein LRP15).

PP1R7_HUMAN
NC score	0.051121 (rank : 1091)	θ value	θ > 10 (rank : 1003)
Query Neighborhood Hits	495	Target Neighborhood Hits	265	Shared Neighborhood Hits	36
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

MK11_HUMAN
NC score	0.051089 (rank : 1092)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	495	Target Neighborhood Hits	823	Shared Neighborhood Hits	83
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

GRK4_HUMAN
NC score	0.051046 (rank : 1093)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	495	Target Neighborhood Hits	822	Shared Neighborhood Hits	84
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

M4K4_HUMAN
NC score	0.051030 (rank : 1094)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	495	Target Neighborhood Hits	1589	Shared Neighborhood Hits	88
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

KKCC1_MOUSE
NC score	0.051025 (rank : 1095)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	495	Target Neighborhood Hits	866	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KCC1D_MOUSE
NC score	0.051008 (rank : 1096)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	495	Target Neighborhood Hits	847	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

RXFP2_HUMAN
NC score	0.050941 (rank : 1097)	θ value	θ > 10 (rank : 1072)
Query Neighborhood Hits	495	Target Neighborhood Hits	736	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

MK12_HUMAN
NC score	0.050916 (rank : 1098)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	495	Target Neighborhood Hits	830	Shared Neighborhood Hits	84
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

TSSK2_HUMAN
NC score	0.050886 (rank : 1099)	θ value	θ > 10 (rank : 1160)
Query Neighborhood Hits	495	Target Neighborhood Hits	826	Shared Neighborhood Hits	83
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

MAMC2_HUMAN
NC score	0.050885 (rank : 1100)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	495	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MK13_HUMAN
NC score	0.050878 (rank : 1101)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	495	Target Neighborhood Hits	829	Shared Neighborhood Hits	84
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

KRA53_HUMAN
NC score	0.050842 (rank : 1102)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	495	Target Neighborhood Hits	331	Shared Neighborhood Hits	24
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KCC1D_HUMAN
NC score	0.050826 (rank : 1103)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

M3K4_MOUSE
NC score	0.050804 (rank : 1104)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	495	Target Neighborhood Hits	924	Shared Neighborhood Hits	85
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

CHK1_HUMAN
NC score	0.050802 (rank : 1105)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	495	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MK13_MOUSE
NC score	0.050792 (rank : 1106)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	495	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MAMC2_MOUSE
NC score	0.050728 (rank : 1107)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	495	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

CDKL5_HUMAN
NC score	0.050629 (rank : 1108)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	495	Target Neighborhood Hits	967	Shared Neighborhood Hits	92
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

PRKX_MOUSE
NC score	0.050592 (rank : 1109)	θ value	θ > 10 (rank : 1004)
Query Neighborhood Hits	495	Target Neighborhood Hits	846	Shared Neighborhood Hits	85
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

TBK1_HUMAN
NC score	0.050554 (rank : 1110)	θ value	θ > 10 (rank : 1126)
Query Neighborhood Hits	495	Target Neighborhood Hits	861	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

CHK1_MOUSE
NC score	0.050525 (rank : 1111)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	495	Target Neighborhood Hits	839	Shared Neighborhood Hits	84
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

KPCB_MOUSE
NC score	0.050465 (rank : 1112)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	495	Target Neighborhood Hits	1117	Shared Neighborhood Hits	88
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

CCRK_HUMAN
NC score	0.050342 (rank : 1113)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

LAMA1_MOUSE
NC score	0.050322 (rank : 1114)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	45
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

MK14_HUMAN
NC score	0.050290 (rank : 1115)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	495	Target Neighborhood Hits	838	Shared Neighborhood Hits	84
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

AL2S2_HUMAN
NC score	0.050249 (rank : 1116)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	495	Target Neighborhood Hits	727	Shared Neighborhood Hits	78
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

KPCB_HUMAN
NC score	0.050201 (rank : 1117)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	495	Target Neighborhood Hits	1121	Shared Neighborhood Hits	88
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

WEE1_MOUSE
NC score	0.050175 (rank : 1118)	θ value	θ > 10 (rank : 1176)
Query Neighborhood Hits	495	Target Neighborhood Hits	794	Shared Neighborhood Hits	75
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

BRSK2_HUMAN
NC score	0.050163 (rank : 1119)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	495	Target Neighborhood Hits	897	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

TBK1_MOUSE
NC score	0.050134 (rank : 1120)	θ value	θ > 10 (rank : 1127)
Query Neighborhood Hits	495	Target Neighborhood Hits	893	Shared Neighborhood Hits	82
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

MK12_MOUSE
NC score	0.050117 (rank : 1121)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	495	Target Neighborhood Hits	835	Shared Neighborhood Hits	85
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

TLR9_HUMAN
NC score	0.050021 (rank : 1122)	θ value	θ > 10 (rank : 1146)
Query Neighborhood Hits	495	Target Neighborhood Hits	295	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NR96, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3	Gene names	TLR9
Domain Architecture
Description	Toll-like receptor 9 precursor (CD289 antigen).

FMOD_HUMAN
NC score	0.050010 (rank : 1123)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	41
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

KS6B1_MOUSE
NC score	0.050007 (rank : 1124)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	495	Target Neighborhood Hits	849	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

RIMB1_HUMAN
NC score	0.046605 (rank : 1125)	θ value	0.0113563 (rank : 336)
Query Neighborhood Hits	495	Target Neighborhood Hits	1479	Shared Neighborhood Hits	47
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TRI42_MOUSE
NC score	0.045901 (rank : 1126)	θ value	8.99809 (rank : 493)
Query Neighborhood Hits	495	Target Neighborhood Hits	316	Shared Neighborhood Hits	41
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

I10R2_MOUSE
NC score	0.041790 (rank : 1127)	θ value	5.27518 (rank : 459)
Query Neighborhood Hits	495	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	Q61190	Gene names	Il10rb, Crfb4
Domain Architecture
Description	Interleukin-10 receptor beta chain precursor (IL-10R-B) (IL-10R2) (Cytokine receptor family 2 member 4) (Cytokine receptor class-II member 4) (CRF2-4) (CDw210b antigen).

UBP2L_MOUSE
NC score	0.041696 (rank : 1128)	θ value	0.0193708 (rank : 343)
Query Neighborhood Hits	495	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

UBP2L_HUMAN
NC score	0.041095 (rank : 1129)	θ value	0.0252991 (rank : 350)
Query Neighborhood Hits	495	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

FANK1_MOUSE
NC score	0.037943 (rank : 1130)	θ value	0.21417 (rank : 382)
Query Neighborhood Hits	495	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

LIRB5_HUMAN
NC score	0.036609 (rank : 1131)	θ value	1.38821 (rank : 422)
Query Neighborhood Hits	495	Target Neighborhood Hits	100	Shared Neighborhood Hits	40
SwissProt Accessions	O75023, Q8N760	Gene names	LILRB5, LIR8
Domain Architecture
Description	Leukocyte immunoglobulin-like receptor subfamily B member 5 precursor (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD85c antigen).

FANK1_HUMAN
NC score	0.036484 (rank : 1132)	θ value	1.06291 (rank : 414)
Query Neighborhood Hits	495	Target Neighborhood Hits	326	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

SLAF6_MOUSE
NC score	0.033827 (rank : 1133)	θ value	4.03905 (rank : 452)
Query Neighborhood Hits	495	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ET39, Q9ET40	Gene names	Slamf6, Ly108
Domain Architecture	No domain graphic available
Description	SLAM family member 6 precursor (Lymphocyte antigen 108).

BTNL8_HUMAN
NC score	0.033374 (rank : 1134)	θ value	4.03905 (rank : 445)
Query Neighborhood Hits	495	Target Neighborhood Hits	177	Shared Neighborhood Hits	65
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

LSR_MOUSE
NC score	0.032627 (rank : 1135)	θ value	0.163984 (rank : 379)
Query Neighborhood Hits	495	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q99KG5, Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816	Gene names	Lsr, Lisch7
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor precursor (Liver-specific bHLH-Zip transcription factor) (Lipolysis-stimulated receptor) (Liver- specific gene on mouse chromosome 7 protein).

TRI18_HUMAN
NC score	0.032618 (rank : 1136)	θ value	8.99809 (rank : 491)
Query Neighborhood Hits	495	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

I13R2_HUMAN
NC score	0.032216 (rank : 1137)	θ value	8.99809 (rank : 483)
Query Neighborhood Hits	495	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q14627, O00667	Gene names	IL13RA2, IL13R
Domain Architecture	No domain graphic available
Description	Interleukin-13 receptor alpha-2 chain precursor (Interleukin-13- binding protein) (CD213a2 antigen).

RIMB1_MOUSE
NC score	0.029705 (rank : 1138)	θ value	0.0431538 (rank : 361)
Query Neighborhood Hits	495	Target Neighborhood Hits	1376	Shared Neighborhood Hits	32
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SET1A_HUMAN
NC score	0.029513 (rank : 1139)	θ value	0.0113563 (rank : 337)
Query Neighborhood Hits	495	Target Neighborhood Hits	690	Shared Neighborhood Hits	21
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

INGR1_MOUSE
NC score	0.028489 (rank : 1140)	θ value	1.38821 (rank : 420)
Query Neighborhood Hits	495	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	P15261	Gene names	Ifngr1, Ifngr
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen).

LSR_HUMAN
NC score	0.026710 (rank : 1141)	θ value	1.38821 (rank : 423)
Query Neighborhood Hits	495	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

BTNL3_HUMAN
NC score	0.022035 (rank : 1142)	θ value	0.813845 (rank : 406)
Query Neighborhood Hits	495	Target Neighborhood Hits	143	Shared Neighborhood Hits	44
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

UROL1_MOUSE
NC score	0.020034 (rank : 1143)	θ value	8.99809 (rank : 494)
Query Neighborhood Hits	495	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	Q5DID3, Q5DID1, Q5DID2	Gene names	Umodl1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

I10R2_HUMAN
NC score	0.018904 (rank : 1144)	θ value	4.03905 (rank : 448)
Query Neighborhood Hits	495	Target Neighborhood Hits	43	Shared Neighborhood Hits	15
SwissProt Accessions	Q08334, Q9BUU4	Gene names	IL10RB, CRFB4
Domain Architecture
Description	Interleukin-10 receptor beta chain precursor (IL-10R-B) (IL-10R2) (Cytokine receptor family 2 member 4) (Cytokine receptor class-II member 4) (CRF2-4) (CDw210b antigen).

MUC1_HUMAN
NC score	0.018702 (rank : 1145)	θ value	0.813845 (rank : 411)
Query Neighborhood Hits	495	Target Neighborhood Hits	975	Shared Neighborhood Hits	29
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

TRI46_MOUSE
NC score	0.018478 (rank : 1146)	θ value	6.88961 (rank : 477)
Query Neighborhood Hits	495	Target Neighborhood Hits	287	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

PCLO_MOUSE
NC score	0.018285 (rank : 1147)	θ value	5.27518 (rank : 463)
Query Neighborhood Hits	495	Target Neighborhood Hits	2275	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ARI4A_HUMAN
NC score	0.017345 (rank : 1148)	θ value	0.21417 (rank : 380)
Query Neighborhood Hits	495	Target Neighborhood Hits	434	Shared Neighborhood Hits	6
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

TRI46_HUMAN
NC score	0.016685 (rank : 1149)	θ value	6.88961 (rank : 476)
Query Neighborhood Hits	495	Target Neighborhood Hits	291	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

CNOT2_HUMAN
NC score	0.014040 (rank : 1150)	θ value	5.27518 (rank : 456)
Query Neighborhood Hits	495	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZN8, Q9H3E0, Q9NSX5, Q9NWR6, Q9P028	Gene names	CNOT2, CDC36, NOT2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

CNOT2_MOUSE
NC score	0.011736 (rank : 1151)	θ value	5.27518 (rank : 457)
Query Neighborhood Hits	495	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C5L3, Q3UE39, Q80YA5, Q9D0P1	Gene names	Cnot2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

NTHL1_HUMAN
NC score	0.011272 (rank : 1152)	θ value	1.38821 (rank : 425)
Query Neighborhood Hits	495	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P78549, Q99566, Q99794, Q9BPX2	Gene names	NTHL1, NTH1, OCTS3
Domain Architecture
Description	Endonuclease III-like protein 1 (EC 4.2.99.18).

LIRB4_MOUSE
NC score	0.010748 (rank : 1153)	θ value	5.27518 (rank : 462)
Query Neighborhood Hits	495	Target Neighborhood Hits	56	Shared Neighborhood Hits	19
SwissProt Accessions	Q64281, Q64312	Gene names	Lilrb4, Gp49b
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 4 precursor (Mast cell surface glycoprotein Gp49B).

AP3B1_MOUSE
NC score	0.010257 (rank : 1154)	θ value	1.06291 (rank : 412)
Query Neighborhood Hits	495	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

UBP7_HUMAN
NC score	0.009928 (rank : 1155)	θ value	1.06291 (rank : 417)
Query Neighborhood Hits	495	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	Q93009	Gene names	USP7, HAUSP
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease).

PK1L1_HUMAN
NC score	0.009233 (rank : 1156)	θ value	2.36792 (rank : 435)
Query Neighborhood Hits	495	Target Neighborhood Hits	140	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

RP1_MOUSE
NC score	0.008256 (rank : 1157)	θ value	8.99809 (rank : 489)
Query Neighborhood Hits	495	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	P56716	Gene names	Rp1, Orp1, Rp1h
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog).

NOL4_HUMAN
NC score	0.008096 (rank : 1158)	θ value	6.88961 (rank : 473)
Query Neighborhood Hits	495	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	O94818, Q9BWF1	Gene names	NOL4, NOLP
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4 (Nucleolar-localized protein).

AGO61_HUMAN
NC score	0.008021 (rank : 1159)	θ value	5.27518 (rank : 453)
Query Neighborhood Hits	495	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NAT1, Q96SY3	Gene names	AGO61, C3orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized glycosyltransferase AGO61 precursor (EC 2.4.-.-).

AGO61_MOUSE
NC score	0.007758 (rank : 1160)	θ value	6.88961 (rank : 465)
Query Neighborhood Hits	495	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BW41, Q58F17, Q8BXZ9, Q8K0M5	Gene names	Ago61
Domain Architecture	No domain graphic available
Description	Uncharacterized glycosyltransferase AGO61 precursor (EC 2.4.-.-).

K0174_HUMAN
NC score	0.006852 (rank : 1161)	θ value	5.27518 (rank : 461)
Query Neighborhood Hits	495	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P53990, Q9BQ81, Q9BWN2	Gene names	KIAA0174
Domain Architecture
Description	Protein KIAA0174 (Putative MAPK-activating protein PM28).

DSPP_HUMAN
NC score	0.006628 (rank : 1162)	θ value	5.27518 (rank : 458)
Query Neighborhood Hits	495	Target Neighborhood Hits	645	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

RC3H1_HUMAN
NC score	0.006563 (rank : 1163)	θ value	3.0926 (rank : 443)
Query Neighborhood Hits	495	Target Neighborhood Hits	433	Shared Neighborhood Hits	19
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

MBB1A_HUMAN
NC score	0.006006 (rank : 1164)	θ value	8.99809 (rank : 486)
Query Neighborhood Hits	495	Target Neighborhood Hits	665	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

IGLL1_HUMAN
NC score	0.004911 (rank : 1165)	θ value	4.03905 (rank : 449)
Query Neighborhood Hits	495	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	P15814	Gene names	IGLL1, IGL1
Domain Architecture
Description	Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin- related protein 14.1) (Immunoglobulin omega polypeptide) (Ig lambda-5) (CD179b antigen).

MGAT2_HUMAN
NC score	0.004498 (rank : 1166)	θ value	6.88961 (rank : 472)
Query Neighborhood Hits	495	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q10469	Gene names	MGAT2
Domain Architecture
Description	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Mannoside acetylglucosaminyltransferase 2) (N- glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II) (Beta-1,2-N-acetylglucosaminyltransferase II) (GNT-II) (GlcNAc-T II).

PCLO_HUMAN
NC score	0.004284 (rank : 1167)	θ value	8.99809 (rank : 488)
Query Neighborhood Hits	495	Target Neighborhood Hits	2046	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

FILA_HUMAN
NC score	0.004211 (rank : 1168)	θ value	0.163984 (rank : 378)
Query Neighborhood Hits	495	Target Neighborhood Hits	685	Shared Neighborhood Hits	11
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

FA54A_MOUSE
NC score	0.004166 (rank : 1169)	θ value	6.88961 (rank : 468)
Query Neighborhood Hits	495	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VED8	Gene names	Fam54a, Dufd1
Domain Architecture	No domain graphic available
Description	Protein FAM54A (DUF729 domain-containing protein 1).

AP3B1_HUMAN
NC score	0.004100 (rank : 1170)	θ value	5.27518 (rank : 454)
Query Neighborhood Hits	495	Target Neighborhood Hits	283	Shared Neighborhood Hits	10
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

NUMBL_MOUSE
NC score	0.003838 (rank : 1171)	θ value	6.88961 (rank : 474)
Query Neighborhood Hits	495	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

NUMBL_HUMAN
NC score	0.001288 (rank : 1172)	θ value	8.99809 (rank : 487)
Query Neighborhood Hits	495	Target Neighborhood Hits	394	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

MAP1B_MOUSE
NC score	0.001162 (rank : 1173)	θ value	6.88961 (rank : 471)
Query Neighborhood Hits	495	Target Neighborhood Hits	977	Shared Neighborhood Hits	21
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

ITPR2_MOUSE
NC score	0.001066 (rank : 1174)	θ value	5.27518 (rank : 460)
Query Neighborhood Hits	495	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

BBX_HUMAN
NC score	-0.000676 (rank : 1175)	θ value	8.99809 (rank : 479)
Query Neighborhood Hits	495	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY36, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q9H0J6	Gene names	BBX, HBP2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).

DHX57_HUMAN
NC score	-0.001050 (rank : 1176)	θ value	8.99809 (rank : 480)
Query Neighborhood Hits	495	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

VAV3_MOUSE
NC score	-0.001122 (rank : 1177)	θ value	8.99809 (rank : 495)
Query Neighborhood Hits	495	Target Neighborhood Hits	404	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

TBCD1_HUMAN
NC score	-0.001277 (rank : 1178)	θ value	6.88961 (rank : 475)
Query Neighborhood Hits	495	Target Neighborhood Hits	276	Shared Neighborhood Hits	3
SwissProt Accessions	Q86TI0, Q96K82, Q9UPP4	Gene names	TBC1D1, KIAA1108
Domain Architecture
Description	TBC1 domain family member 1.

G3BP_MOUSE
NC score	-0.001448 (rank : 1179)	θ value	8.99809 (rank : 482)
Query Neighborhood Hits	495	Target Neighborhood Hits	209	Shared Neighborhood Hits	6
SwissProt Accessions	P97855	Gene names	G3bp, G3bp1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

DUS2_MOUSE
NC score	-0.001969 (rank : 1180)	θ value	8.99809 (rank : 481)
Query Neighborhood Hits	495	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q05922, Q60640	Gene names	Dusp2, Pac-1, Pac1
Domain Architecture
Description	Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase PAC-1).

DGKZ_MOUSE
NC score	-0.003717 (rank : 1181)	θ value	4.03905 (rank : 446)
Query Neighborhood Hits	495	Target Neighborhood Hits	542	Shared Neighborhood Hits	5
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DLG1_MOUSE
NC score	-0.003942 (rank : 1182)	θ value	6.88961 (rank : 467)
Query Neighborhood Hits	495	Target Neighborhood Hits	285	Shared Neighborhood Hits	5
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

BAZ2B_HUMAN
NC score	-0.004478 (rank : 1183)	θ value	8.99809 (rank : 478)
Query Neighborhood Hits	495	Target Neighborhood Hits	803	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).