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Network neighborhood for query Sequence : SOCS3_HUMAN

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SOCS3_HUMAN
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SOCS3_MOUSE
θ value	7.6132e-116 (rank : 1)	NC score	0.996636 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS3_HUMAN
θ value	1.53757e-108 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

CISH_MOUSE
θ value	3.88503e-19 (rank : 3)	NC score	0.803777 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SOCS2_HUMAN
θ value	7.32683e-18 (rank : 4)	NC score	0.792539 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	104	Shared Neighborhood Hits	54
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	1.63225e-17 (rank : 5)	NC score	0.797793 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

CISH_HUMAN
θ value	2.7842e-17 (rank : 6)	NC score	0.799555 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

SOCS1_HUMAN
θ value	5.25075e-16 (rank : 7)	NC score	0.793475 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	79	Shared Neighborhood Hits	51
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	1.52774e-15 (rank : 8)	NC score	0.792696 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS7_MOUSE
θ value	1.47974e-10 (rank : 9)	NC score	0.697186 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	154	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOCS6_HUMAN
θ value	9.59137e-10 (rank : 10)	NC score	0.653007 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	126	Shared Neighborhood Hits	57
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	9.59137e-10 (rank : 11)	NC score	0.650393 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	146	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS4_MOUSE
θ value	6.43352e-06 (rank : 12)	NC score	0.533795 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_HUMAN
θ value	1.43324e-05 (rank : 13)	NC score	0.529030 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

P85A_MOUSE
θ value	5.44631e-05 (rank : 14)	NC score	0.374466 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P55G_HUMAN
θ value	7.1131e-05 (rank : 15)	NC score	0.418768 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	451	Shared Neighborhood Hits	67
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SOCS5_HUMAN
θ value	9.29e-05 (rank : 16)	NC score	0.520741 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	91	Shared Neighborhood Hits	47
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	9.29e-05 (rank : 17)	NC score	0.519662 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

P85A_HUMAN
θ value	0.000121331 (rank : 18)	NC score	0.366975 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	479	Shared Neighborhood Hits	65
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P55G_MOUSE
θ value	0.00035302 (rank : 19)	NC score	0.420979 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	401	Shared Neighborhood Hits	67
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
θ value	0.00134147 (rank : 20)	NC score	0.375214 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	543	Shared Neighborhood Hits	67
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	0.00134147 (rank : 21)	NC score	0.377858 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	519	Shared Neighborhood Hits	68
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DAPP1_MOUSE
θ value	0.00228821 (rank : 22)	NC score	0.339766 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SHB_HUMAN
θ value	0.00869519 (rank : 23)	NC score	0.261962 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

DAPP1_HUMAN
θ value	0.0148317 (rank : 24)	NC score	0.326823 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

FRK_HUMAN
θ value	0.0148317 (rank : 25)	NC score	0.091735 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	1058	Shared Neighborhood Hits	62
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

PTN11_HUMAN
θ value	0.0193708 (rank : 26)	NC score	0.137638 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.0193708 (rank : 27)	NC score	0.137653 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

CRK_HUMAN
θ value	0.0252991 (rank : 28)	NC score	0.256712 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	308	Shared Neighborhood Hits	67
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0252991 (rank : 29)	NC score	0.252905 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	314	Shared Neighborhood Hits	67
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCK1_HUMAN
θ value	0.0330416 (rank : 30)	NC score	0.237161 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PTN6_HUMAN
θ value	0.0330416 (rank : 31)	NC score	0.134616 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	234	Shared Neighborhood Hits	63
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	0.0330416 (rank : 32)	NC score	0.141211 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

BLK_HUMAN
θ value	0.0736092 (rank : 33)	NC score	0.084633 (rank : 106)
Query Neighborhood Hits	77	Target Neighborhood Hits	994	Shared Neighborhood Hits	56
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SLAP1_MOUSE
θ value	0.0736092 (rank : 34)	NC score	0.223925 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	117	Shared Neighborhood Hits	55
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

CSK_MOUSE
θ value	0.0961366 (rank : 35)	NC score	0.096909 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	1009	Shared Neighborhood Hits	66
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

LYN_MOUSE
θ value	0.0961366 (rank : 36)	NC score	0.086537 (rank : 102)
Query Neighborhood Hits	77	Target Neighborhood Hits	1023	Shared Neighborhood Hits	57
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ABL1_HUMAN
θ value	0.125558 (rank : 37)	NC score	0.095789 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	1220	Shared Neighborhood Hits	67
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	0.125558 (rank : 38)	NC score	0.095653 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	1178	Shared Neighborhood Hits	68
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSK_HUMAN
θ value	0.163984 (rank : 39)	NC score	0.096112 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	1009	Shared Neighborhood Hits	66
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

SLAP2_HUMAN
θ value	0.163984 (rank : 40)	NC score	0.242985 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	139	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SRC_HUMAN
θ value	0.163984 (rank : 41)	NC score	0.094959 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	1058	Shared Neighborhood Hits	62
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.163984 (rank : 42)	NC score	0.095579 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	1033	Shared Neighborhood Hits	63
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ZIM10_HUMAN
θ value	0.163984 (rank : 43)	NC score	0.029064 (rank : 147)
Query Neighborhood Hits	77	Target Neighborhood Hits	577	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

HSH2D_HUMAN
θ value	0.21417 (rank : 44)	NC score	0.227140 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	159	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

FGR_MOUSE
θ value	0.365318 (rank : 45)	NC score	0.106587 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	1069	Shared Neighborhood Hits	70
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLAP1_HUMAN
θ value	0.365318 (rank : 46)	NC score	0.220508 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SRMS_HUMAN
θ value	0.365318 (rank : 47)	NC score	0.081945 (rank : 111)
Query Neighborhood Hits	77	Target Neighborhood Hits	946	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ABL2_HUMAN
θ value	0.47712 (rank : 48)	NC score	0.097153 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	1045	Shared Neighborhood Hits	68
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

TENS4_MOUSE
θ value	0.47712 (rank : 49)	NC score	0.140686 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

CHIN_MOUSE
θ value	0.813845 (rank : 50)	NC score	0.096527 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	229	Shared Neighborhood Hits	50
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CRKL_MOUSE
θ value	0.813845 (rank : 51)	NC score	0.227306 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

HCK_MOUSE
θ value	1.06291 (rank : 52)	NC score	0.087950 (rank : 100)
Query Neighborhood Hits	77	Target Neighborhood Hits	1029	Shared Neighborhood Hits	57
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

LYN_HUMAN
θ value	1.06291 (rank : 53)	NC score	0.083147 (rank : 109)
Query Neighborhood Hits	77	Target Neighborhood Hits	1022	Shared Neighborhood Hits	57
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TENS1_HUMAN
θ value	1.06291 (rank : 54)	NC score	0.107899 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	400	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

CHIN_HUMAN
θ value	1.38821 (rank : 55)	NC score	0.090189 (rank : 99)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	44
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

MKL1_MOUSE
θ value	1.38821 (rank : 56)	NC score	0.017721 (rank : 151)
Query Neighborhood Hits	77	Target Neighborhood Hits	667	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

NCK2_HUMAN
θ value	1.38821 (rank : 57)	NC score	0.242259 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	310	Shared Neighborhood Hits	67
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

TENS4_HUMAN
θ value	1.38821 (rank : 58)	NC score	0.157383 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

VAV2_HUMAN
θ value	1.38821 (rank : 59)	NC score	0.138915 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	453	Shared Neighborhood Hits	66
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

BLK_MOUSE
θ value	1.81305 (rank : 60)	NC score	0.085103 (rank : 105)
Query Neighborhood Hits	77	Target Neighborhood Hits	992	Shared Neighborhood Hits	58
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_HUMAN
θ value	1.81305 (rank : 61)	NC score	0.085659 (rank : 104)
Query Neighborhood Hits	77	Target Neighborhood Hits	1035	Shared Neighborhood Hits	59
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SLAP2_MOUSE
θ value	1.81305 (rank : 62)	NC score	0.238521 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	136	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

FGR_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.097929 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	1067	Shared Neighborhood Hits	66
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SHE_HUMAN
θ value	2.36792 (rank : 64)	NC score	0.221895 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	164	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

UROL1_MOUSE
θ value	2.36792 (rank : 65)	NC score	0.018229 (rank : 150)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q5DID3, Q5DID1, Q5DID2	Gene names	Umodl1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

CRKL_HUMAN
θ value	3.0926 (rank : 66)	NC score	0.216945 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	313	Shared Neighborhood Hits	67
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SHE_MOUSE
θ value	3.0926 (rank : 67)	NC score	0.238295 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	169	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SRMS_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.074425 (rank : 117)
Query Neighborhood Hits	77	Target Neighborhood Hits	964	Shared Neighborhood Hits	58
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

VAV2_MOUSE
θ value	3.0926 (rank : 69)	NC score	0.131780 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	456	Shared Neighborhood Hits	64
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PAX9_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.016063 (rank : 153)
Query Neighborhood Hits	77	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

PAX9_MOUSE
θ value	4.03905 (rank : 71)	NC score	0.016150 (rank : 152)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	P47242	Gene names	Pax9, Pax-9
Domain Architecture
Description	Paired box protein Pax-9.

FYN_HUMAN
θ value	5.27518 (rank : 72)	NC score	0.090523 (rank : 98)
Query Neighborhood Hits	77	Target Neighborhood Hits	1078	Shared Neighborhood Hits	68
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	5.27518 (rank : 73)	NC score	0.091615 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	1073	Shared Neighborhood Hits	65
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ELL_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.011284 (rank : 154)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

ICK_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.020889 (rank : 148)
Query Neighborhood Hits	77	Target Neighborhood Hits	867	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.020845 (rank : 149)
Query Neighborhood Hits	77	Target Neighborhood Hits	860	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

ZBT24_MOUSE
θ value	8.99809 (rank : 77)	NC score	-0.004071 (rank : 155)
Query Neighborhood Hits	77	Target Neighborhood Hits	894	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X44, Q3UIB7, Q7TPC4, Q8CJC9	Gene names	Zbtb24, Bif1, Bsg1, Znf450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) (Bone morphogenetic protein-induced factor 1) (Brain-specific protein 1).

APS_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.090646 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.071282 (rank : 128)
Query Neighborhood Hits	77	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

BCAR3_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.082204 (rank : 110)
Query Neighborhood Hits	77	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.077185 (rank : 115)
Query Neighborhood Hits	77	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BLNK_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.050280 (rank : 145)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.059034 (rank : 140)
Query Neighborhood Hits	77	Target Neighborhood Hits	296	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.063403 (rank : 136)
Query Neighborhood Hits	77	Target Neighborhood Hits	942	Shared Neighborhood Hits	48
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.063104 (rank : 137)
Query Neighborhood Hits	77	Target Neighborhood Hits	912	Shared Neighborhood Hits	48
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BTK_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.073037 (rank : 121)
Query Neighborhood Hits	77	Target Neighborhood Hits	1026	Shared Neighborhood Hits	53
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.072851 (rank : 123)
Query Neighborhood Hits	77	Target Neighborhood Hits	1017	Shared Neighborhood Hits	53
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CHIO_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.075178 (rank : 116)
Query Neighborhood Hits	77	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

FER_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.073744 (rank : 119)
Query Neighborhood Hits	77	Target Neighborhood Hits	1278	Shared Neighborhood Hits	58
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

GRAP2_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.152885 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	304	Shared Neighborhood Hits	56
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.152028 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.145694 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.146997 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	309	Shared Neighborhood Hits	53
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB10_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.073325 (rank : 120)
Query Neighborhood Hits	77	Target Neighborhood Hits	147	Shared Neighborhood Hits	49
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.069969 (rank : 130)
Query Neighborhood Hits	77	Target Neighborhood Hits	156	Shared Neighborhood Hits	48
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.092024 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.097637 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	149	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.157895 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	310	Shared Neighborhood Hits	57
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.159159 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.072774 (rank : 124)
Query Neighborhood Hits	77	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.079357 (rank : 113)
Query Neighborhood Hits	77	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HSH2D_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.166598 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	124	Shared Neighborhood Hits	48
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ITK_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.065932 (rank : 135)
Query Neighborhood Hits	77	Target Neighborhood Hits	1016	Shared Neighborhood Hits	52
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.066040 (rank : 134)
Query Neighborhood Hits	77	Target Neighborhood Hits	985	Shared Neighborhood Hits	53
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KSYK_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.060410 (rank : 139)
Query Neighborhood Hits	77	Target Neighborhood Hits	901	Shared Neighborhood Hits	52
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.061393 (rank : 138)
Query Neighborhood Hits	77	Target Neighborhood Hits	944	Shared Neighborhood Hits	52
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LCK_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.079679 (rank : 112)
Query Neighborhood Hits	77	Target Neighborhood Hits	987	Shared Neighborhood Hits	55
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.078916 (rank : 114)
Query Neighborhood Hits	77	Target Neighborhood Hits	981	Shared Neighborhood Hits	57
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.096883 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	531	Shared Neighborhood Hits	38
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.117620 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.105579 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.107727 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	132	Shared Neighborhood Hits	49
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MATK_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.085948 (rank : 103)
Query Neighborhood Hits	77	Target Neighborhood Hits	954	Shared Neighborhood Hits	68
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.086749 (rank : 101)
Query Neighborhood Hits	77	Target Neighborhood Hits	952	Shared Neighborhood Hits	65
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

NPHP1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.053485 (rank : 144)
Query Neighborhood Hits	77	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.056354 (rank : 143)
Query Neighborhood Hits	77	Target Neighborhood Hits	267	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PLCG1_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.153755 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.152243 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	314	Shared Neighborhood Hits	65
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.144337 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	280	Shared Neighborhood Hits	57
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PTK6_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.073907 (rank : 118)
Query Neighborhood Hits	77	Target Neighborhood Hits	1020	Shared Neighborhood Hits	55
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.072531 (rank : 125)
Query Neighborhood Hits	77	Target Neighborhood Hits	1026	Shared Neighborhood Hits	56
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RASA1_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.134514 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	258	Shared Neighborhood Hits	53
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21A_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.100446 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	33
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.099340 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	33
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.133971 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.142267 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.107731 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.109084 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	179	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.071110 (rank : 129)
Query Neighborhood Hits	77	Target Neighborhood Hits	149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.094017 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	455	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.104998 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	326	Shared Neighborhood Hits	45
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.068493 (rank : 133)
Query Neighborhood Hits	77	Target Neighborhood Hits	188	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.069800 (rank : 131)
Query Neighborhood Hits	77	Target Neighborhood Hits	174	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.222592 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.104750 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.114185 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.113714 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.113936 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	144	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.144397 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	155	Shared Neighborhood Hits	52
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.133786 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	151	Shared Neighborhood Hits	53
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.188891 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	59
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.193800 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	58
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SRBS1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.050017 (rank : 146)
Query Neighborhood Hits	77	Target Neighborhood Hits	396	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TEC_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.071682 (rank : 126)
Query Neighborhood Hits	77	Target Neighborhood Hits	1006	Shared Neighborhood Hits	56
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.068927 (rank : 132)
Query Neighborhood Hits	77	Target Neighborhood Hits	1006	Shared Neighborhood Hits	54
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.071446 (rank : 127)
Query Neighborhood Hits	77	Target Neighborhood Hits	971	Shared Neighborhood Hits	57
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.073025 (rank : 122)
Query Neighborhood Hits	77	Target Neighborhood Hits	980	Shared Neighborhood Hits	57
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

VAV3_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.145467 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	398	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.147554 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	404	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.137489 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	452	Shared Neighborhood Hits	61
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.123943 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	430	Shared Neighborhood Hits	57
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

YES_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.083266 (rank : 107)
Query Neighborhood Hits	77	Target Neighborhood Hits	1059	Shared Neighborhood Hits	58
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.083178 (rank : 108)
Query Neighborhood Hits	77	Target Neighborhood Hits	1052	Shared Neighborhood Hits	58
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.057133 (rank : 142)
Query Neighborhood Hits	77	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.057164 (rank : 141)
Query Neighborhood Hits	77	Target Neighborhood Hits	905	Shared Neighborhood Hits	53
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

SOCS3_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.53757e-108 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
NC score	0.996636 (rank : 2)	θ value	7.6132e-116 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

CISH_MOUSE
NC score	0.803777 (rank : 3)	θ value	3.88503e-19 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CISH_HUMAN
NC score	0.799555 (rank : 4)	θ value	2.7842e-17 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

SOCS2_MOUSE
NC score	0.797793 (rank : 5)	θ value	1.63225e-17 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS1_HUMAN
NC score	0.793475 (rank : 6)	θ value	5.25075e-16 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	79	Shared Neighborhood Hits	51
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
NC score	0.792696 (rank : 7)	θ value	1.52774e-15 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS2_HUMAN
NC score	0.792539 (rank : 8)	θ value	7.32683e-18 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	104	Shared Neighborhood Hits	54
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS7_MOUSE
NC score	0.697186 (rank : 9)	θ value	1.47974e-10 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	154	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOCS6_HUMAN
NC score	0.653007 (rank : 10)	θ value	9.59137e-10 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	126	Shared Neighborhood Hits	57
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.650393 (rank : 11)	θ value	9.59137e-10 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	146	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS4_MOUSE
NC score	0.533795 (rank : 12)	θ value	6.43352e-06 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_HUMAN
NC score	0.529030 (rank : 13)	θ value	1.43324e-05 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS5_HUMAN
NC score	0.520741 (rank : 14)	θ value	9.29e-05 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	91	Shared Neighborhood Hits	47
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
NC score	0.519662 (rank : 15)	θ value	9.29e-05 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

P55G_MOUSE
NC score	0.420979 (rank : 16)	θ value	0.00035302 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	401	Shared Neighborhood Hits	67
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_HUMAN
NC score	0.418768 (rank : 17)	θ value	7.1131e-05 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	451	Shared Neighborhood Hits	67
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_MOUSE
NC score	0.377858 (rank : 18)	θ value	0.00134147 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	519	Shared Neighborhood Hits	68
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_HUMAN
NC score	0.375214 (rank : 19)	θ value	0.00134147 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	543	Shared Neighborhood Hits	67
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85A_MOUSE
NC score	0.374466 (rank : 20)	θ value	5.44631e-05 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_HUMAN
NC score	0.366975 (rank : 21)	θ value	0.000121331 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	479	Shared Neighborhood Hits	65
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DAPP1_MOUSE
NC score	0.339766 (rank : 22)	θ value	0.00228821 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.326823 (rank : 23)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SHB_HUMAN
NC score	0.261962 (rank : 24)	θ value	0.00869519 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

CRK_HUMAN
NC score	0.256712 (rank : 25)	θ value	0.0252991 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	308	Shared Neighborhood Hits	67
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.252905 (rank : 26)	θ value	0.0252991 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	314	Shared Neighborhood Hits	67
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SLAP2_HUMAN
NC score	0.242985 (rank : 27)	θ value	0.163984 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	139	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

NCK2_HUMAN
NC score	0.242259 (rank : 28)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	310	Shared Neighborhood Hits	67
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SLAP2_MOUSE
NC score	0.238521 (rank : 29)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	136	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SHE_MOUSE
NC score	0.238295 (rank : 30)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	169	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

NCK1_HUMAN
NC score	0.237161 (rank : 31)	θ value	0.0330416 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CRKL_MOUSE
NC score	0.227306 (rank : 32)	θ value	0.813845 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

HSH2D_HUMAN
NC score	0.227140 (rank : 33)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	159	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SLAP1_MOUSE
NC score	0.223925 (rank : 34)	θ value	0.0736092 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	117	Shared Neighborhood Hits	55
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SHB_MOUSE
NC score	0.222592 (rank : 35)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHE_HUMAN
NC score	0.221895 (rank : 36)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	164	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
NC score	0.220508 (rank : 37)	θ value	0.365318 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

CRKL_HUMAN
NC score	0.216945 (rank : 38)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	313	Shared Neighborhood Hits	67
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SHD_MOUSE
NC score	0.193800 (rank : 39)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	58
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_HUMAN
NC score	0.188891 (rank : 40)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	59
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

HSH2D_MOUSE
NC score	0.166598 (rank : 41)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	77	Target Neighborhood Hits	124	Shared Neighborhood Hits	48
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

GRB2_MOUSE
NC score	0.159159 (rank : 42)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	77	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.157895 (rank : 43)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	77	Target Neighborhood Hits	310	Shared Neighborhood Hits	57
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

TENS4_HUMAN
NC score	0.157383 (rank : 44)	θ value	1.38821 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

PLCG1_HUMAN
NC score	0.153755 (rank : 45)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	77	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

GRAP2_HUMAN
NC score	0.152885 (rank : 46)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	304	Shared Neighborhood Hits	56
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PLCG1_MOUSE
NC score	0.152243 (rank : 47)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	77	Target Neighborhood Hits	314	Shared Neighborhood Hits	65
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

GRAP2_MOUSE
NC score	0.152028 (rank : 48)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

VAV3_MOUSE
NC score	0.147554 (rank : 49)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	77	Target Neighborhood Hits	404	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GRAP_MOUSE
NC score	0.146997 (rank : 50)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	309	Shared Neighborhood Hits	53
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.145694 (rank : 51)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

VAV3_HUMAN
NC score	0.145467 (rank : 52)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	77	Target Neighborhood Hits	398	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SHC3_HUMAN
NC score	0.144397 (rank : 53)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	77	Target Neighborhood Hits	155	Shared Neighborhood Hits	52
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

PLCG2_HUMAN
NC score	0.144337 (rank : 54)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	77	Target Neighborhood Hits	280	Shared Neighborhood Hits	57
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SH21B_MOUSE
NC score	0.142267 (rank : 55)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PTN6_MOUSE
NC score	0.141211 (rank : 56)	θ value	0.0330416 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

TENS4_MOUSE
NC score	0.140686 (rank : 57)	θ value	0.47712 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

VAV2_HUMAN
NC score	0.138915 (rank : 58)	θ value	1.38821 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	453	Shared Neighborhood Hits	66
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PTN11_MOUSE
NC score	0.137653 (rank : 59)	θ value	0.0193708 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.137638 (rank : 60)	θ value	0.0193708 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

VAV_HUMAN
NC score	0.137489 (rank : 61)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	77	Target Neighborhood Hits	452	Shared Neighborhood Hits	61
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PTN6_HUMAN
NC score	0.134616 (rank : 62)	θ value	0.0330416 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	234	Shared Neighborhood Hits	63
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

RASA1_HUMAN
NC score	0.134514 (rank : 63)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	77	Target Neighborhood Hits	258	Shared Neighborhood Hits	53
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21B_HUMAN
NC score	0.133971 (rank : 64)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHC3_MOUSE
NC score	0.133786 (rank : 65)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	77	Target Neighborhood Hits	151	Shared Neighborhood Hits	53
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

VAV2_MOUSE
NC score	0.131780 (rank : 66)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	456	Shared Neighborhood Hits	64
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.123943 (rank : 67)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	77	Target Neighborhood Hits	430	Shared Neighborhood Hits	57
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

LCP2_MOUSE
NC score	0.117620 (rank : 68)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	77	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SHC1_MOUSE
NC score	0.114185 (rank : 69)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	77	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_MOUSE
NC score	0.113936 (rank : 70)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	77	Target Neighborhood Hits	144	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.113714 (rank : 71)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SH22A_MOUSE
NC score	0.109084 (rank : 72)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	77	Target Neighborhood Hits	179	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

TENS1_HUMAN
NC score	0.107899 (rank : 73)	θ value	1.06291 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	400	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

SH22A_HUMAN
NC score	0.107731 (rank : 74)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	77	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

LNK_MOUSE
NC score	0.107727 (rank : 75)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	77	Target Neighborhood Hits	132	Shared Neighborhood Hits	49
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FGR_MOUSE
NC score	0.106587 (rank : 76)	θ value	0.365318 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	1069	Shared Neighborhood Hits	70
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LNK_HUMAN
NC score	0.105579 (rank : 77)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	77	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SH24A_MOUSE
NC score	0.104998 (rank : 78)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	77	Target Neighborhood Hits	326	Shared Neighborhood Hits	45
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SHC1_HUMAN
NC score	0.104750 (rank : 79)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SH21A_HUMAN
NC score	0.100446 (rank : 80)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	33
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
NC score	0.099340 (rank : 81)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	33
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

FGR_HUMAN
NC score	0.097929 (rank : 82)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	1067	Shared Neighborhood Hits	66
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GRB14_MOUSE
NC score	0.097637 (rank : 83)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	149	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ABL2_HUMAN
NC score	0.097153 (rank : 84)	θ value	0.47712 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	1045	Shared Neighborhood Hits	68
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CSK_MOUSE
NC score	0.096909 (rank : 85)	θ value	0.0961366 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	1009	Shared Neighborhood Hits	66
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

LCP2_HUMAN
NC score	0.096883 (rank : 86)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	77	Target Neighborhood Hits	531	Shared Neighborhood Hits	38
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CHIN_MOUSE
NC score	0.096527 (rank : 87)	θ value	0.813845 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	229	Shared Neighborhood Hits	50
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CSK_HUMAN
NC score	0.096112 (rank : 88)	θ value	0.163984 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	1009	Shared Neighborhood Hits	66
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ABL1_HUMAN
NC score	0.095789 (rank : 89)	θ value	0.125558 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	1220	Shared Neighborhood Hits	67
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.095653 (rank : 90)	θ value	0.125558 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	1178	Shared Neighborhood Hits	68
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SRC_MOUSE
NC score	0.095579 (rank : 91)	θ value	0.163984 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	1033	Shared Neighborhood Hits	63
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRC_HUMAN
NC score	0.094959 (rank : 92)	θ value	0.163984 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	1058	Shared Neighborhood Hits	62
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SH24A_HUMAN
NC score	0.094017 (rank : 93)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	77	Target Neighborhood Hits	455	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

GRB14_HUMAN
NC score	0.092024 (rank : 94)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

FRK_HUMAN
NC score	0.091735 (rank : 95)	θ value	0.0148317 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	1058	Shared Neighborhood Hits	62
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_MOUSE
NC score	0.091615 (rank : 96)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	1073	Shared Neighborhood Hits	65
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

APS_HUMAN
NC score	0.090646 (rank : 97)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

FYN_HUMAN
NC score	0.090523 (rank : 98)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	1078	Shared Neighborhood Hits	68
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

CHIN_HUMAN
NC score	0.090189 (rank : 99)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	44
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

HCK_MOUSE
NC score	0.087950 (rank : 100)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	1029	Shared Neighborhood Hits	57
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MATK_MOUSE
NC score	0.086749 (rank : 101)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	77	Target Neighborhood Hits	952	Shared Neighborhood Hits	65
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

LYN_MOUSE
NC score	0.086537 (rank : 102)	θ value	0.0961366 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	1023	Shared Neighborhood Hits	57
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MATK_HUMAN
NC score	0.085948 (rank : 103)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	77	Target Neighborhood Hits	954	Shared Neighborhood Hits	68
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

HCK_HUMAN
NC score	0.085659 (rank : 104)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	1035	Shared Neighborhood Hits	59
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

BLK_MOUSE
NC score	0.085103 (rank : 105)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	992	Shared Neighborhood Hits	58
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_HUMAN
NC score	0.084633 (rank : 106)	θ value	0.0736092 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	994	Shared Neighborhood Hits	56
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

YES_HUMAN
NC score	0.083266 (rank : 107)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	77	Target Neighborhood Hits	1059	Shared Neighborhood Hits	58
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.083178 (rank : 108)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	77	Target Neighborhood Hits	1052	Shared Neighborhood Hits	58
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

LYN_HUMAN
NC score	0.083147 (rank : 109)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	1022	Shared Neighborhood Hits	57
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BCAR3_HUMAN
NC score	0.082204 (rank : 110)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

SRMS_HUMAN
NC score	0.081945 (rank : 111)	θ value	0.365318 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	946	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

LCK_HUMAN
NC score	0.079679 (rank : 112)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	77	Target Neighborhood Hits	987	Shared Neighborhood Hits	55
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

GRB7_MOUSE
NC score	0.079357 (rank : 113)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	77	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LCK_MOUSE
NC score	0.078916 (rank : 114)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	77	Target Neighborhood Hits	981	Shared Neighborhood Hits	57
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BCAR3_MOUSE
NC score	0.077185 (rank : 115)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

CHIO_HUMAN
NC score	0.075178 (rank : 116)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SRMS_MOUSE
NC score	0.074425 (rank : 117)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	964	Shared Neighborhood Hits	58
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

PTK6_HUMAN
NC score	0.073907 (rank : 118)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	77	Target Neighborhood Hits	1020	Shared Neighborhood Hits	55
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

FER_HUMAN
NC score	0.073744 (rank : 119)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	1278	Shared Neighborhood Hits	58
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

GRB10_HUMAN
NC score	0.073325 (rank : 120)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	147	Shared Neighborhood Hits	49
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

BTK_HUMAN
NC score	0.073037 (rank : 121)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	1026	Shared Neighborhood Hits	53
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

TXK_MOUSE
NC score	0.073025 (rank : 122)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	77	Target Neighborhood Hits	980	Shared Neighborhood Hits	57
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BTK_MOUSE
NC score	0.072851 (rank : 123)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	1017	Shared Neighborhood Hits	53
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

GRB7_HUMAN
NC score	0.072774 (rank : 124)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	77	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

PTK6_MOUSE
NC score	0.072531 (rank : 125)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	77	Target Neighborhood Hits	1026	Shared Neighborhood Hits	56
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TEC_HUMAN
NC score	0.071682 (rank : 126)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	77	Target Neighborhood Hits	1006	Shared Neighborhood Hits	56
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
NC score	0.071446 (rank : 127)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	77	Target Neighborhood Hits	971	Shared Neighborhood Hits	57
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

APS_MOUSE
NC score	0.071282 (rank : 128)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH23A_HUMAN
NC score	0.071110 (rank : 129)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	77	Target Neighborhood Hits	149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

GRB10_MOUSE
NC score	0.069969 (rank : 130)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	156	Shared Neighborhood Hits	48
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

SH2D3_MOUSE
NC score	0.069800 (rank : 131)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	77	Target Neighborhood Hits	174	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

TEC_MOUSE
NC score	0.068927 (rank : 132)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	77	Target Neighborhood Hits	1006	Shared Neighborhood Hits	54
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SH2D3_HUMAN
NC score	0.068493 (rank : 133)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	77	Target Neighborhood Hits	188	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

ITK_MOUSE
NC score	0.066040 (rank : 134)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	77	Target Neighborhood Hits	985	Shared Neighborhood Hits	53
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.065932 (rank : 135)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	77	Target Neighborhood Hits	1016	Shared Neighborhood Hits	52
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

BMX_HUMAN
NC score	0.063403 (rank : 136)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	942	Shared Neighborhood Hits	48
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.063104 (rank : 137)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	912	Shared Neighborhood Hits	48
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

KSYK_MOUSE
NC score	0.061393 (rank : 138)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	77	Target Neighborhood Hits	944	Shared Neighborhood Hits	52
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.060410 (rank : 139)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	77	Target Neighborhood Hits	901	Shared Neighborhood Hits	52
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

BLNK_MOUSE
NC score	0.059034 (rank : 140)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	296	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

ZAP70_MOUSE
NC score	0.057164 (rank : 141)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	77	Target Neighborhood Hits	905	Shared Neighborhood Hits	53
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_HUMAN
NC score	0.057133 (rank : 142)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	77	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

NPHP1_MOUSE
NC score	0.056354 (rank : 143)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	77	Target Neighborhood Hits	267	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NPHP1_HUMAN
NC score	0.053485 (rank : 144)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	77	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

BLNK_HUMAN
NC score	0.050280 (rank : 145)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

SRBS1_HUMAN
NC score	0.050017 (rank : 146)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	77	Target Neighborhood Hits	396	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ZIM10_HUMAN
NC score	0.029064 (rank : 147)	θ value	0.163984 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	577	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ICK_HUMAN
NC score	0.020889 (rank : 148)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	867	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
NC score	0.020845 (rank : 149)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	860	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

UROL1_MOUSE
NC score	0.018229 (rank : 150)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q5DID3, Q5DID1, Q5DID2	Gene names	Umodl1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

MKL1_MOUSE
NC score	0.017721 (rank : 151)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	667	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

PAX9_MOUSE
NC score	0.016150 (rank : 152)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	P47242	Gene names	Pax9, Pax-9
Domain Architecture
Description	Paired box protein Pax-9.

PAX9_HUMAN
NC score	0.016063 (rank : 153)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

ELL_MOUSE
NC score	0.011284 (rank : 154)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

ZBT24_MOUSE
NC score	-0.004071 (rank : 155)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	894	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X44, Q3UIB7, Q7TPC4, Q8CJC9	Gene names	Zbtb24, Bif1, Bsg1, Znf450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) (Bone morphogenetic protein-induced factor 1) (Brain-specific protein 1).